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SSTR5 Gene

protein-coding   GIFtS: 66
GCID: GC16P001122

Somatostatin Receptor 5

  See SSTR5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Somatostatin Receptor 51 2
SS-5-R2 3
Somatostatin Receptor Subtype 52
Somatostatin Receptor Type 52
SS5-R3
SS5R3

External Ids:    HGNC: 113341   Entrez Gene: 67552   Ensembl: ENSG000001620097   OMIM: 1824555   UniProtKB: P353463   

Export aliases for SSTR5 gene to outside databases

Previous GC identifers: GC16P001143 GC16P001068


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSTR5 Gene:
Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue
targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs,
which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of
this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor
molecule are required for the activation of different signaling pathways. A mutation in this gene results in
somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this
gene.(provided by RefSeq, Feb 2010)

GeneCards Summary for SSTR5 Gene:
SSTR5 (somatostatin receptor 5) is a protein-coding gene. Diseases associated with SSTR5 include pancreatic endocrine carcinoma, and non-functioning pituitary adenoma. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346
Function: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor
is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2
following heterodimerization

summary for SSTR5 Gene:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR5 (Somatostatin receptor 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSTR5 gene promoter:
         p53   Bach2   LCR-F1   C/EBPalpha   E47   CREB   ZID   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SSTR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSTR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SSTR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001122:  view genomic region     (about GC identifiers)

Start:
1,122,756 bp from pter      End:
1,131,454 bp from pter
Size:
8,699 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346 (See protein sequence)
Recommended Name: Somatostatin receptor type 5  
Size: 364 amino acids; 39202 Da
Subunit: Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2
Secondary accessions: P34988 Q541E0 Q9UJI5

Explore the universe of human proteins at neXtProt for SSTR5: NX_P35346

Explore proteomics data for SSTR5 at MOPED

Post-translational modifications: 

  • Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which
    is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts1
  • Glycosylation2 at Asn13, Asn26, Asn187
  • Modification sites at PhosphoSitePlus

  • See SSTR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001044.1  NP_001166031.1  

    ENSEMBL proteins: 
     ENSP00000454964   ENSP00000380680   ENSP00000293897  
    Reactome Protein details: P35346

    SSTR5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant SSTR5 Protein
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    Novus Biologicals SSTR5 Protein
    Novus Biologicals SSTR5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSTR5

     
    Search eBioscience for Proteins for SSTR5 

     
    antibodies-online proteins for SSTR5 (3 products) 

     
    antibodies-online peptides for SSTR5

    SSTR5 Antibody Products:

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    antibodies-online antibodies for SSTR5 (40 products) 

    SSTR5 Assay Products:

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    Cloud-Clone Corp. ELISAs for SSTR5
    Cloud-Clone Corp. CLIAs for SSTR5
    Search eBioscience for ELISAs for SSTR5 
    antibodies-online kits for SSTR5 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SSTR: GPCR / Class A : Somatostatin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: sst5 receptor
    Somatostatin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001184 Somatstn_rcpt_5
     IPR000586 Somatstn_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P35346

    ProtoNet protein and cluster: P35346

    2 Blocks protein domains:
    IPB000586 Somatostatin receptor signature
    IPB001184 Somatostatin receptor type 5 signature


    UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with SSTR5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSR5_HUMAN, P35346
    Function: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor
    is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2
    following heterodimerization

         Genatlas biochemistry entry for SSTR5:
    somatostatin receptor gene 5,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004994somatostatin receptor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SSTR5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SSTR5:
     Decreased influenza A/WSN/33 r 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Sstr5):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 

    Find genes that share phenotypes with SSTR5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sstr5tm1Fcb for SSTR5

       genOway: Develop your customized and physiologically relevant rodent model for SSTR5

    miRNA
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
    Products:
       

     
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSR5_HUMAN, P35346: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7908405
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SSTR5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSTR5 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with SSTR5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SSTR5
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for SSTR5
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for SSTR5):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including SSTR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SSTR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSTR5 (P353463 ENSP000002938974) via UniProtKB, MINT, STRING, and/or I2D (see all 153)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOPCQ9HD263, ENSP000003574844I2D: score=3 STRING: ENSP00000357484
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    SSTP612783, ENSP000002876414I2D: score=1 STRING: ENSP00000287641
    ADCY10Q96PN63, ENSP000003568254I2D: score=1 STRING: ENSP00000356825
    DRD2P144163, ENSP000003548594I2D: score=2 STRING: ENSP00000354859
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9892014
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS7908405
    GO:0008285negative regulation of cell proliferation TAS9892014
    GO:0032467positive regulation of cytokinesis IMP--
    GO:0038170somatostatin signaling pathway TAS9892014

    Find genes that share ontologies with SSTR5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SSTR5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    CYN 154806Selective sst2 antagonist[183658-72-2]
    (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Potent and selective sst2 agonist[208706-12-1]

    3 DrugBank Compounds for SSTR5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    OctreotideOctreotida [Spanish] (see all 3)83150-76-9target--16625841 16086874 16438887 16625842 16809928
    Pasireotide-- 396091-73-9target--17395978 11980628
    VapreotideBMY 41606 (see all 6)103222-11-3targetagonist19708854

    Selected IUPHAR Ligands for SSTR5 (sst5 receptor) (see all 45)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]LTT-SRIF-28
    AgonistFull agonist10.59650799 10598788
    SRIF-28
    AgonistFull agonist9.2 - 10.315333679 7988476 10598788 9652348 9650799 9600011 8769372
    [125I]Tyr10-CST14
    AgonistFull agonist10.39650799 10598788
    CST-17
    AgonistFull agonist8.5 - 10.29650799 15333679 10598788
    MK-678
    AgonistFull agonist6.6 - 10.27988476 10598788 9652348 9724791 9650799 9600011 8769372
    [125I]Tyr11-SRIF-14
    AgonistFull agonist108078491
    SRIF-14
    AgonistFull agonist8.4 - 9.915333679 10598788 11520208 9724791 9784130 9650799 9600011 8769372 7988476 9652348
    SOM-230
    AgonistFull agonist9.815477717
    CST-14
    AgonistFull agonist8.4 - 9.79650799 10598788 9652348
    [125I]Tyr3 SMS 201-995
    AgonistFull agonist9.6410598788 9652348

    Selected Novoseek inferred chemical compound relationships for SSTR5 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lanreotide 88 9 18778119 (1), 11231991 (1), 15799207 (1), 15671091 (1) (see all 9)
    octreotide 86.7 31 20464704 (4), 11231991 (3), 17159301 (3), 15994755 (2) (see all 16)
    pasireotide 81.3 1 17395978 (1)
    111in-pentetreotide 63.9 2 16625862 (1), 19307732 (1)
    ribonucleic acid 48.7 4 10487698 (1), 10902809 (1), 11231991 (1), 7521350 (1)
    acth 29.5 2 15817922 (1), 15769796 (1)
    glyceraldehyde 3-phosphate 23.6 4 10487698 (1), 10690891 (1), 11231991 (1)
    dopamine 23.5 9 15994755 (2), 19003539 (2), 16216913 (1), 16625841 (1) (see all 6)
    thymidine 0 1 11344221 (1)
    calcium 0 2 7878022 (1), 8961277 (1)



    Find genes that share compounds with SSTR5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSTR5 gene (4 alternative transcripts): 
    NM_001053.3  NM_001172560.1  NM_001172572.1  NM_001172573.1  

    Unigene Cluster for SSTR5:

    Somatostatin receptor 5
    Hs.449840  [show with all ESTs]
    Unigene Representative Sequence: NM_001053
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562758 ENST00000397547(uc021taf.1) ENST00000293897(uc002ckq.3)

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      QuantiFast Probe-based Assays in human, mouse, rat SSTR5

    Additional mRNA sequence: 

    AK308381.1 DQ448303.1 DQ448304.1 

    3 DOTS entries:

    DT.91707440  DT.95189877  DT.75170796 

    14 AceView cDNA sequences:

    CN838037 CK825458 BM702398 NM_001053 AI393288 AU279805 CK825459 BQ270941 
    BF764911 BI765565 BQ271239 AJ706985 BG897323 CN837866 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSTR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTGGTGG
    SSTR5 Expression
    About this image

    SSTR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSTR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449840

    UniProtKB/Swiss-Prot: SSR5_HUMAN, P35346
    Tissue specificity: Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal
    hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary

        Pathway & Disease-focused RT2 Profiler PCR Array including SSTR5: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SSTR5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SSTR5 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sstr51 , 5 somatostatin receptor 51, 5 79.35(n)1
    81.11(a)1
      17 (12.62 cM)5
    206091  NM_011425.31  NP_035555.11 
     254898755 
    chicken
    (Gallus gallus)
    Aves SSTR51 somatostatin receptor 5 65.12(n)
    66.86(a)
      427667  NM_001024834.1  NP_001020005.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSTR56
    somatostatin receptor 5
    64(a)
    1 ↔ 1
    GL343263.1(1760857-1761951)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sstr51 somatostatin receptor 5 66.28(n)
    68.8(a)
      100486456  XM_002932283.2  XP_002932329.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:856821 zgc:85682 60.48(n)
    56.57(a)
      406588  NM_213297.1  NP_998462.1 


    ENSEMBL Gene Tree for SSTR5 (if available)
    TreeFam Gene Tree for SSTR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSTR5 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  
    GALR22  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for SSTR5 using alignment to 4 protein entries:     SSR5_HUMAN (see all proteins) (see all similar genes):
    SSTR2    SSTR4    SSTR3    SSTR1    C3AR1    CX3CR1
    GHSR    CCR2    HTR2B    OPRM1    CCR-5    CXCR2
    CCR7    CCR3    OPRD1    GPR141    GPR24    OPRK1

    Find genes that share paralogs with SSTR5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSTR5 (see all 54)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1873410031,2
    --1052022(+) CAGTGA/CCCAAG 1 -- us2k10--------
    rs773704131,2
    C--1126350(+) TCCCAC/-CCCCG 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs357812611,2
    F--1130804(+) GTCCAG/TTGTGG 2 -- ut311Minor allele frequency- T:0.50NA 4
    rs1869991011,2
    --1130860(+) CTGAGA/GGTCAG 2 -- ut310--------
    rs1165505271,2
    C,F--1130927(+) TGGCCC/TGGGAG 2 -- ut312Minor allele frequency- T:0.08WA NA 238
    rs781347251,2
    C,F--1130929(+) GCCCGG/AGAGAG 2 -- ut312Minor allele frequency- A:0.08WA NA 238
    rs1398060891,2
    C--1130940(+) GGAACA/GGGGAC 2 -- ut310--------
    rs1931658631,2
    --1130976(+) GCAGCA/GGGGAG 2 -- ut310--------
    rs1155258711,2
    C,F--1131063(+) AATCCC/TGCCGC 2 -- ut311Minor allele frequency- T:0.05WA 118
    rs1420846481,2
    C--1131067(+) CCGCCA/GCCTCC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SSTR5 (1122756 - 1131454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SSTR5 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv904901CNV Loss21882294
    dgv2510n71CNV Loss21882294
    dgv2519n71CNV Loss21882294
    nsv904932CNV Loss21882294
    nsv457323CNV Loss19166990
    nsv471066CNV Loss18288195
    dgv2514n71CNV Loss21882294
    dgv2505n71CNV Loss21882294
    dgv2504n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): SSTR5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSTR5
    DNA2.0 Custom Variant and Variant Library Synthesis for SSTR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182455   
    OMIM disorders: 102200  
    19 diseases for SSTR5:    
    About MalaCards
    pancreatic endocrine carcinoma    non-functioning pituitary adenoma    somatostatin analog    functioning pituitary adenoma
    familial isolated pituitary adenoma    pancreatic endocrine tumors    aip-related familial isolated pituitary adenomas    pituitary adenoma
    glucagonoma    oncogenic osteomalacia    pituitary tumors    prolactinoma
    gastrinoma    acromegaly    osteomalacia    insulinoma
    adenoma    pheochromocytoma    pancreatic cancer

    3 diseases from the University of Copenhagen DISEASES database for SSTR5:
    Adenoma     Acromegaly     Pituitary adenoma

    Find genes that share disorders with SSTR5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SSTR5 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 80.2 12 11399907 (1), 20464704 (1), 16216913 (1), 10100234 (1) (see all 11)
    prolactinoma 79.4 15 10487698 (2), 7521350 (2), 16595604 (1), 7908405 (1) (see all 9)
    acromegaly 73.2 6 15914528 (1), 11399907 (1), 11081177 (1), 19533047 (1) (see all 6)
    pituitary tumors 70.9 5 7908405 (2), 9709982 (1), 7521350 (1), 19401364 (1)
    adenoma 66.8 46 11399907 (4), 14661732 (4), 11231991 (3), 11264647 (2) (see all 19)
    pituitary adenoma nonfunctioning 65.4 3 15472224 (1)
    insulinoma 60.3 7 16601280 (3), 12021920 (1), 7908405 (1), 16263117 (1)
    glucagonoma 57.2 2 8132773 (1), 12021920 (1)
    gastrinoma 54.7 1 12021920 (1)
    carcinoid 48.3 1 16508627 (1)

    Genetic Association Database (GAD): SSTR5
    Human Genome Epidemiology (HuGE) Navigator: SSTR5 (13 documents)

    Export disorders for SSTR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSTR5 gene, integrated from 10 sources (see all 202):
    (articles sorted by number of sources associating them with SSTR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder. (PubMed id 12192619)1, 4, 9 Nyegaard M....Kruse T.A. (Mol. Psychiatry 2002)
    2. Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. (PubMed id 7908405)1, 2, 9 Panetta R.... Patel Y.C. (Mol. Pharmacol. 1994)
    3. Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. (PubMed id 15914528)1, 4, 9 Filopanti M....Spada A. (J. Clin. Endocrinol. Metab. 2005)
    4. Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. (PubMed id 18653781)1, 2, 9 Grant M....Kumar U. (Mol. Endocrinol. 2008)
    5. Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. (PubMed id 19423539)1, 4, 9 Johansson M....Kaaks R. (amp 2009)
    6. Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization. (PubMed id 7607700)1, 3, 9 Takeda J....Bell G.I. (Genomics 1995)
    7. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. (PubMed id 21820437)1, 2 Kokkola T.... Kreienkamp H.J. (FEBS Lett. 2011)
    8. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    10. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6755 HGNC: 11334 AceView: SSTR5 Ensembl:ENSG00000162009 euGenes: HUgn6755
    ECgene: SSTR5 Kegg: 6755 H-InvDB: SSTR5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSTR5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSTR5 gene:
    Search GeneIP for patents involving SSTR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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