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Aliases for SSTR5 Gene

Aliases for SSTR5 Gene

  • Somatostatin Receptor 5 2 3
  • SS-5-R 3 4
  • Somatostatin Receptor Subtype 5 3
  • Somatostatin Receptor Type 5 3
  • SS5-R 4
  • SS5R 4

External Ids for SSTR5 Gene

Summaries for SSTR5 Gene

Entrez Gene Summary for SSTR5 Gene

  • Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]

GeneCards Summary for SSTR5 Gene

SSTR5 (Somatostatin Receptor 5) is a Protein Coding gene. Diseases associated with SSTR5 include non-functioning pituitary adenoma and functioning pituitary adenoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for SSTR5 Gene

  • Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

Tocris Summary for SSTR5 Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the voltage sensor and is activated by changes in membrane potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR5 Gene

Genomics for SSTR5 Gene

Genomic Location for SSTR5 Gene

Start:
1,072,756 bp from pter
End:
1,081,454 bp from pter
Size:
8,699 bases
Orientation:
Plus strand

Genomic View for SSTR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSTR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR5 Gene

Regulatory Elements for SSTR5 Gene

Proteins for SSTR5 Gene

  • Protein details for SSTR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35346-SSR5_HUMAN
    Recommended name:
    Somatostatin receptor type 5
    Protein Accession:
    P35346
    Secondary Accessions:
    • P34988
    • Q541E0
    • Q9UJI5

    Protein attributes for SSTR5 Gene

    Size:
    364 amino acids
    Molecular mass:
    39202 Da
    Quaternary structure:
    • Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2.

neXtProt entry for SSTR5 Gene

Proteomics data for SSTR5 Gene at MOPED

Post-translational modifications for SSTR5 Gene

  • Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn13, Asn26, and Asn187

Other Protein References for SSTR5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR5 Gene

Domains for SSTR5 Gene

Gene Families for SSTR5 Gene

HGNC:
  • SSTR :GPCR / Class A : Somatostatin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

SSR5_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P35346
genes like me logo Genes that share domains with SSTR5: view

Function for SSTR5 Gene

Molecular function for SSTR5 Gene

GENATLAS Biochemistry: somatostatin receptor gene 5,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.

Gene Ontology (GO) - Molecular Function for SSTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004994 somatostatin receptor activity IEA --
GO:0005515 protein binding --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR5: view

Phenotypes for SSTR5 Gene

genes like me logo Genes that share phenotypes with SSTR5: view

Animal Models for SSTR5 Gene

MGI Knock Outs for SSTR5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SSTR5 Gene

Localization for SSTR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR5 Gene COMPARTMENTS Subcellular localization image for SSTR5 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7908405
GO:0016021 integral component of membrane --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with SSTR5: view

Pathways for SSTR5 Gene

genes like me logo Genes that share pathways with SSTR5: view

Pathways by source for SSTR5 Gene

Gene Ontology (GO) - Biological Process for SSTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9892014
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7908405
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission IBA --
GO:0008285 negative regulation of cell proliferation TAS 9892014
genes like me logo Genes that share ontologies with SSTR5: view

Compounds for SSTR5 Gene

(5) Tocris Compounds for SSTR5 Gene

Compound Action Cas Number
(1R,1S,3R/1R,1R,3S)-L-054,264 Potent and selective sst2 agonist [208706-12-1]
Cyclosomatostatin Non-selective sst receptor antagonist [84211-54-1]
CYN 154806 Selective sst2 antagonist [183658-72-2]
Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
Somatostatin Influences growth hormone release [51110-01-1]

(3) Drugbank Compounds for SSTR5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Octreotide
  • Octreotida [Spanish]
83150-76-9 target
Pasireotide
396091-73-9 target
Vapreotide
  • BMY 41606
103222-11-3 target agonist

(45) IUPHAR Ligand for SSTR5 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]LTT-SRIF-28 Agonist Full agonist 10.3
[125I]Tyr10-CST14 Agonist Full agonist 10.1
SRIF-14 Agonist Full agonist 10
SRIF-28 Agonist Full agonist 9.9
CST-17 Agonist Full agonist 9.9
CST-14 Agonist Full agonist 9.9
[125I]CGP 23996 Agonist Full agonist 9.8
BIM 23052 Agonist Full agonist 9.7
BIM 23313 Agonist Full agonist 9.6
BIM 23059 Agonist Full agonist 9.4
CGP 23996 Agonist Full agonist 9.3
BIM 23060 Agonist Full agonist 9.2
[125I]Tyr11-SRIF-14 Agonist Full agonist 9
[125I]Tyr3 SMS 201-995 Agonist Full agonist 8.89
SOM-230 Agonist Full agonist 8.8
KE 108 Agonist Full agonist 8.8
BIM 23268 Agonist Full agonist 8.7
octreotide Agonist Full agonist 8.6
L-817,818 Agonist Full agonist 8.5
Des-AA5-[D-Trp8]SRIF Agonist Full agonist 8.5
L-362,855 Agonist Full agonist 8.3
[111In]DOTA-BOC-ATE Agonist Full agonist 8.3
BIM 23023 Agonist Full agonist 8.1
[111In]DOTA-NOC Agonist Full agonist 8.1
lanreotide Agonist Full agonist 8
MK-678 Agonist Full agonist 7.9
vapreotide Agonist Full agonist 7.9
[111In]DOTA-NOC-ATE Agonist Full agonist 7.9
BIM 23050 Agonist Full agonist 7.8
BIM 23030 Agonist Full agonist 7.8
[111In,90Y]DOTA-NOC Agonist Full agonist 7.6
BIM 23197 Agonist Full agonist 7.6
[111In,90Y]DOTA-OC Agonist Full agonist 7.6
BOC-ATE Agonist Full agonist 7.5
BIM 23627 Antagonist Antagonist 7.4
BIM 23454 Antagonist Antagonist 7.3
BIM 23056 Agonist Full agonist 7.2
L-363,301 Agonist Full agonist 7
PRL-2970 Antagonist Antagonist 7
PRL-2915 Antagonist Antagonist 7
[L-Tyr8]CYN 154806 Antagonist Antagonist 6.8
[D-Tyr8]CYN 154806 Antagonist Antagonist 6.7
NOC-ATE Agonist Full agonist 6.5
[111In,90Y]DOTA-LAN Agonist Full agonist 6.5
[111In,90Y]DOTA-TOC Agonist Full agonist 6.4

(11) Novoseek inferred chemical compound relationships for SSTR5 Gene

Compound -log(P) Hits PubMed IDs
lanreotide 88 9
octreotide 86.7 25
pasireotide 81.3 1
111in-pentetreotide 63.9 2
ribonucleic acid 48.7 4
genes like me logo Genes that share compounds with SSTR5: view

Transcripts for SSTR5 Gene

mRNA/cDNA for SSTR5 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSTR5 Gene

Somatostatin receptor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR5 Gene

No ASD Table

Relevant External Links for SSTR5 Gene

GeneLoc Exon Structure for
SSTR5
ECgene alternative splicing isoforms for
SSTR5

Expression for SSTR5 Gene

mRNA expression in normal human tissues for SSTR5 Gene

mRNA differential expression in normal tissues according to GTEx for SSTR5 Gene

This gene is overexpressed in Pituitary (15.8), Heart - Atrial Appendage (11.7), and Heart - Left Ventricle (9.0).

SOURCE GeneReport for Unigene cluster for SSTR5 Gene Hs.449840

mRNA Expression by UniProt/SwissProt for SSTR5 Gene

P35346-SSR5_HUMAN
Tissue specificity: Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.
genes like me logo Genes that share expressions with SSTR5: view

Orthologs for SSTR5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR5 36
  • 98.81 (n)
  • 99.18 (a)
SSTR5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSTR5 36
  • 85.35 (n)
  • 81.59 (a)
SSTR5 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSTR5 36
  • 86.78 (n)
  • 83.2 (a)
SSTR5 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sstr5 36
  • 79.35 (n)
  • 81.11 (a)
Sstr5 16
Sstr5 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSTR5 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSTR5 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr5 36
  • 80.09 (n)
  • 81.67 (a)
chicken
(Gallus gallus)
Aves SS5R 37
  • 64 (a)
OneToOne
SSTR5 36
  • 65.12 (n)
  • 66.86 (a)
lizard
(Anolis carolinensis)
Reptilia SSTR5 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr5 36
  • 66.28 (n)
  • 68.8 (a)
zebrafish
(Danio rerio)
Actinopterygii SSTR5 37
  • 50 (a)
OneToOne
zgc:85682 36
  • 60.48 (n)
  • 56.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Drostar1 38
  • 43 (a)
AlCR2 38
  • 41 (a)
Species with no ortholog for SSTR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR5 Gene

ENSEMBL:
Gene Tree for SSTR5 (if available)
TreeFam:
Gene Tree for SSTR5 (if available)

Paralogs for SSTR5 Gene

genes like me logo Genes that share paralogs with SSTR5: view

Variants for SSTR5 Gene

Sequence variations from dbSNP and Humsavar for SSTR5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs197055 -- 1,081,175(+) GGGCA(A/C)CTTGG utr-variant-3-prime
rs197056 -- 1,081,695(+) CTCAC(A/G)GCTTC downstream-variant-500B
rs1469820 -- 1,081,879(+) TCTCA(C/G)AAGGC downstream-variant-500B
rs2072988 -- 1,081,514(+) TGAGC(G/T)GAGCC downstream-variant-500B
rs2076420 -- 1,081,373(+) CTGAG(A/G)CCAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SSTR5 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv791e1 CNV Complex 17122850
nsv457315 CNV Gain 19166990
nsv471066 CNV Loss 18288195
dgv792e1 CNV Complex 17122850
nsv428316 CNV Gain+Loss 18775914
nsv833116 CNV Loss 17160897
dgv2504n71 CNV Loss 21882294
dgv2505n71 CNV Loss 21882294
dgv2507n71 CNV Loss 21882294
nsv904861 CNV Gain 21882294
dgv2509n71 CNV Loss 21882294
dgv2510n71 CNV Loss 21882294
dgv2511n71 CNV Loss 21882294
nsv471067 CNV Gain 18288195
nsv904901 CNV Loss 21882294
dgv2513n71 CNV Loss 21882294
dgv2514n71 CNV Loss 21882294
dgv2515n71 CNV Loss 21882294
dgv2516n71 CNV Loss 21882294
nsv904913 CNV Loss 21882294
dgv2517n71 CNV Loss 21882294
dgv2518n71 CNV Loss 21882294
dgv2519n71 CNV Loss 21882294
nsv457323 CNV Loss 19166990
nsv523609 CNV Loss 19592680
nsv904932 CNV Loss 21882294
nsv9329 CNV Gain 18304495

Relevant External Links for SSTR5 Gene

HapMap Linkage Disequilibrium report
SSTR5
Human Gene Mutation Database (HGMD)
SSTR5

Disorders for SSTR5 Gene

(1) OMIM Diseases for SSTR5 Gene (182455)

(3) University of Copenhagen DISEASES for SSTR5 Gene

(19) Novoseek inferred disease relationships for SSTR5 Gene

Disease -log(P) Hits PubMed IDs
pituitary adenoma 80.2 11
prolactinoma 79.4 11
acromegaly 73.2 6
pituitary tumors 70.9 5
adenoma 66.8 33

Relevant External Links for SSTR5

Genetic Association Database (GAD)
SSTR5
Human Genome Epidemiology (HuGE) Navigator
SSTR5
genes like me logo Genes that share disorders with SSTR5: view

No data available for UniProtKB/Swiss-Prot for SSTR5 Gene

Publications for SSTR5 Gene

  1. Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization. (PMID: 7607700) Takeda J. … Bell G.I. (Genomics 1995) 2 3 23
  2. Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. (PMID: 7908405) Panetta R. … Patel Y.C. (Mol. Pharmacol. 1994) 3 4 23
  3. Novel polymorphisms in the somatostatin receptor 5 (SSTR5) gene associated with bipolar affective disorder. (PMID: 12192619) Nyegaard M. … Kruse T.A. (Mol. Psychiatry 2002) 3 23 49
  4. Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. (PMID: 15914528) Filopanti M. … Spada A. (J. Clin. Endocrinol. Metab. 2005) 3 23 49
  5. Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. (PMID: 18653781) Grant M. … Kumar U. (Mol. Endocrinol. 2008) 3 4 23

Products for SSTR5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SSTR5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SSTR5
    • Block miRNA regulation of SSTR5 using miScript Target Protectors

    Sources for SSTR5 Gene

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