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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSTR4 Gene

protein-coding   GIFtS: 64
GCID: GC20P022964

somatostatin receptor 4
 Explore 28 diseases affiliated with
SSTR4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SSTR4    

Aliases
for SSTR4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Somatostatin Receptor 41 2
SS-4-R2 3
SS4-R2 3
SS4R2 3
G-Protein Coupled Receptor2
Somatostatin Receptor Type 42

External Ids:    HGNC: 113331   Entrez Gene: 67542   Ensembl: ENSG000001326717   OMIM: 1824545   UniProtKB: P313913   

Export aliases for SSTR4 gene to outside databases

Previous GC identifers: GC20P023004 GC20P023011


Summaries
for SSTR4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SSTR4:
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic
effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a
tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is
expressed in highest levels in fetal and adult brain and lung. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391
Function: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl
cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both
arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of
somatostatin in tumor cells

summary for SSTR4:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR4 (Somatostatin receptor 4)


Genomic Views
for SSTR4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSTR4 gene promoter:
         p53   NF-kappaB   Meis-1b   FOXJ2 (long isoform)   Meis-1a   FOXJ2   NF-kappaB1   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSTR4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSTR4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSTR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.2   Ensembl cytogenetic band:  20p11.21   HGNC chromosome: 20

SSTR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P022964:  view genomic region     (about GC identifiers)

Start:
 23,016,057 bp from pter      End:
 23,017,314 bp from pter
Size:
 1,258 bases      Orientation:
 plus strand

Proteins
for SSTR4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391 (See protein sequence)
Recommended Name: Somatostatin receptor type 4  
Size: 388 amino acids; 42003 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q17RM1 Q17RM3 Q9UIY1

Explore the universe of human proteins at neXtProt for SSTR4: NX_P31391

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31391

    • SSTR4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001043.2  
    ENSEMBL proteins: 
     ENSP00000255008  
    Reactome Protein details: P31391
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant SSTR4 Protein
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    OriGene Protein Over-expression Lysate: SSTR4
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    Novus Biologicals SSTR4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SSTR4

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8100352


    SSTR4 for ontologies           About GeneDecksing



    SSTR4 Antibody Products: 
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    ThermoFisher Antibody for SSTR4

    Assay Products for SSTR4: 
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    Uscn ELISAs and CLIAs for SSTR4

    Protein Domains /
    Families
    for SSTR4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SSTR4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000586 Somatstn_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001512 Somatstn_rcpt_4

    Graphical View of Domain Structure for InterPro Entry P31391

    ProtoNet protein and cluster: P31391

    2 Blocks protein families:
    IPB000586 Somatostatin receptor signature
    IPB001512 Somatostatin receptor type 4 signature


    UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for SSTR4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391
    Function: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl
    cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both
    arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of
    somatostatin in tumor cells

         Genatlas biochemistry entry for SSTR4:
    somatostatin receptor gene 4,G protein coupled receptor superfamily

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSTR4
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: SSTR4
    OriGene siRNA: SSTR4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSTR4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SSTR4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSTR4 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR4 

    Cell Line
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    Search LifeMap BioReagents cell lines for SSTR4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004994somatostatin receptor activity IEA--


    SSTR4 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for SSTR4:
     Decreased number of cells in m  Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Sstr4tm1Ute for SSTR4
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sstr4):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  integument 
     no phenotypic analysis  respiratory system 

    SSTR4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SSTR4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    		Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    		Peptide GPCRs0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SSTR4
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 BioSystems Pathways for SSTR4 
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for SSTR4 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for SSTR4):
        Neuroactive ligand-receptor interaction


    SSTR4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSTR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/146 Interacting proteins for SSTR4 (P313913 ENSP000002550084) via UniProtKB, MINT, STRING, and/or I2D (see all 146)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    SSTP612783, ENSP000002876414I2D: score=1 STRING: ENSP00000287641
    DLG4P783523I2D: score=2 
    DLG2Q157003I2D: score=1 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9892014
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8405411
    GO:0008285negative regulation of cell proliferation TAS9892014
    GO:0016477cell migration IEA--
    GO:0019369arachidonic acid metabolic process IEA--


    SSTR4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SSTR4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SSTR4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SSTR4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    L-803,087 trifluoroacetate Potent and selective sst4 agonist[217480-26-7]
    RC 160Somatostatin analog[103222-11-3]
    NNC 26-9100Selective sst4 agonist[199522-35-5]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    4 Novoseek chemical compound relationships for SSTR4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 74.2 2 7628822 (1), 8961800 (1)
    lanreotide 60.7 1 7628822 (1)
    ribonucleic acid 42 2 7775631 (1), 7521350 (1)
    tyrosine 0 3 7674817 (1), 16488965 (1)

    Search CenterWatch for drugs/clinical trials and news about SSTR4 / SSR4 

    Transcripts
    for SSTR4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SSTR4 gene: 
    NM_001052.2  

    Unigene Cluster for SSTR4:

    Somatostatin receptor 4
    Hs.673846
    Unigene Representative Sequence: NM_001052
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000255008(uc002wsr.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSTR4
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSTR4 (see all 7)
    OriGene shRNA RFP: SSTR4
    OriGene siRNA: SSTR4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSTR4
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SSTR4 (NM_001052)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSTR4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSTR4

    Additional cDNA sequence: 

    BC069063.1 BC117270.1 BC117272.1 

    1 DOTS entry:

    DT.91909241 

    3 AceView cDNA sequences:

    BV184553 NM_001052 BC069063 

    GeneLoc Exon Structure


    Expression
    for SSTR4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSTR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCCCCCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SSTR4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SSTR4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSTR4

    SOURCE GeneReport for Unigene cluster: Hs.673846

    UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391
    Tissue specificity: Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in
    the kidney, pituitary and adrenals

        SABiosciences Expression via Pathway-Focused PCR Arrays including SSTR4: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for SSTR4

    Orthologs
    for SSTR4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SSTR4 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SSTR41 somatostatin receptor 4 75.61(n)
    73.17(a)    		   428547  NM_001031518.1  NP_001026689.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5576451 somatostatin receptor type 1-like 66.67(n)
    67.19(a)    		   557645  XM_680740.2  XP_685832.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta AlCR23
    star11    		 G-protein coupled receptor protein signaling
    pathway more3
    allatostatin C receptor 11    		 38(a)
    (best of 2)3
    47.65(n)1
    36.34(a)1    		   75D13
    400201  NM_140783.21  NP_649040.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y54E2A.16
    		 --
    		 14(a)
    		 possible ortholog
    		 II(14734335-14739167)


    ENSEMBL Gene Tree for SSTR4 (if available)
    TreeFam Gene Tree for SSTR4 (if available) 

    Paralogs
    for SSTR4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSTR4 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  NPBWR22  OPRM12  MCHR12  
    18/51 SIMAP similar genes for SSTR4 using alignment to 1 protein entry:     SSR4_HUMAN(see all similar genes):
    SSTR2    SSTR1    SSTR5    OPRL1    SSTR3    OPRM1
    OPRK1    NPBWR2    OPRD1    GPR24    CXCR6    CXCR1
    NPBWR1    BLR1    CXCR2    CXCR5    IL8RB    LPAR6

    SSTR4 for paralogs           About GeneDecksing



    Genomic Variants
    for SSTR4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/103 NCBI SNPs in SSTR4 are shown (see all 103)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs355528621,2
    		C,F,--23014126(+) CAGGAA/GAGATT 1 -- us2k15Minor allele frequency- G:0.01NA EU CSAM EA 380
    rs1385416871,2
    		--23014128(+) GGAAAG/TATTCC 1 -- us2k10--------
    rs1411281811,2
    		--23014192(+) GGGGCC/TGAGTG 1 -- us2k10--------
    rs1891894551,2
    		--23014228(+) AGAGAA/GGAGAC 1 -- us2k10--------
    rs1812449031,2
    		--23014244(+) AGACAA/CGATAG 1 -- us2k10--------
    rs340033091,2
    		C,--23014355(+) CTCTTC/TCCTCC 1 -- us2k15Minor allele frequency- T:0.00NA EU CSAM EA 380
    rs72669931,2
    		C,--23014447(+) CTCAGG/CGAAGG 1 -- us2k15Minor allele frequency- C:0.00NA EU CSAM EA 380
    rs359024921,2
    		C,--23014450(+) AGGGAA/TGGGTC 1 -- us2k17Minor allele frequency- T:0.04NA EU CSAM EA WA 500
    rs343076151,2
    		C,--23014453(+) GAAGGG/ATCTCT 1 -- us2k17Minor allele frequency- A:0.05NA EU CSAM EA WA 500
    rs1494905321,2
    		--23014457(+) GGTCTC/TTCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SSTR4 (23016057 - 23017314 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SSTR4
         1 Indel: 50634

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    Disorders / Diseases
    for SSTR4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SSTR4 for disorders           About GeneDecksing

    OMIM gene information: 182454    OMIM disorders: --

    20/28 diseases for SSTR4 (see all 28):    About MalaCards
    functioning pituitary adenoma    pituitary adenoma    prolactinoma    pancreatic endocrine tumors
    sotos syndrome    pituitary tumor    insulinoma    neuroendocrine tumor
    pheochromocytoma    adenoma    graves' disease    acromegaly
    gigantism    hepatitis b    prostate cancer    hermaphroditism
    thyroid carcinoma    hepatocellular carcinoma    alzheimer's disease    laryngitis

    8 Novoseek disease relationships for SSTR4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 61.7 1 7521350 (1)
    prolactinoma 56.5 1 7521350 (1)
    adenoma 45.3 2 8866248 (1), 7521350 (1)
    insulinoma 36.8 2 8132773 (1)
    tumors 29 5 10768564 (1), 17218727 (1), 8961800 (1), 7521350 (1)
    pheochromocytoma 21.5 2 7775631 (2)
    carcinoma 12.3 2 12210479 (1)
    prostate cancer 0 5 9253335 (2), 12210479 (2)

    Genetic Association Database (GAD): SSTR4
    Human Genome Epidemiology (HuGE) Navigator: SSTR4 (7 documents)

    Export disorders for SSTR4 gene to outside databases

    Publications
    for SSTR4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSTR4 gene, integrated from 9 sources (see all 79):
    (articles sorted by number of sources associating them with SSTR4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a fourth human somatostatin receptor. (PubMed id 8483934)1, 2, 3 Rohrer L....Schuele R. (1993)
    2. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. (PubMed id 8100352)1, 2, 9 Demchyshyn L.L.... Niznik H.B. (1993)
    3. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4 Canzian F....Kaaks R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. (PubMed id 8373420)1, 2 Yamada Y.... Seino Y. (1993)
    7. Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. (PubMed id 8512564)1, 2 Xu Y.... Berelowitz M. (1993)
    8. Expression of somatostatin receptor subtypes 2 and 4 in human benign prostatic hyperplasia and prostatic cancer. (PubMed id 12210479)1, 9 Hansson J....Abrahamsson P.A. (2002)
    9. C-tail mediated modulation of somatostatin receptor t ype-4 homo- and heterodimerizations and signaling. (PubMed id 19426801)1, 9 Somvanshi R.K....Kumar U. (2009)
    10. Expression of the somatostatin receptor subtype 4 in intact and inflamed pulmonary tissues. (PubMed id 19687471)1, 9 Varecza Z....Helyes Z. (2009)

    External Searches for SSTR4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SSTR4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6754 HGNC: 11333 AceView: SSTR4 Ensembl:ENSG00000132671 euGenes: HUgn6754
    ECgene: SSTR4 Kegg: 6754 H-InvDB: SSTR4

    Other Databases showing SSTR4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SSTR4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSTR4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR4 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SSTR4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SSTR4 gene:
    Search GeneIP for patents involving SSTR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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