Aliases for SSTR4 Gene
External Ids for SSTR4 Gene
Previous GeneCards Identifiers for SSTR4 Gene
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
GeneCards Summary for SSTR4 Gene
SSTR4 (Somatostatin Receptor 4) is a Protein Coding gene. Diseases associated with SSTR4 include pheochromocytoma and prostate cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is GALR2.
UniProtKB/Swiss-Prot for SSTR4 Gene
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.