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Aliases for SSTR4 Gene

Aliases for SSTR4 Gene

  • Somatostatin Receptor 4 2 3 5
  • SS-4-R 3 4
  • SS4-R 3 4
  • SS4R 3 4
  • Somatostatin Receptor Type 4 3
  • G-Protein Coupled Receptor 3

External Ids for SSTR4 Gene

Previous GeneCards Identifiers for SSTR4 Gene

  • GC20P023004
  • GC20P023011
  • GC20P022964

Summaries for SSTR4 Gene

Entrez Gene Summary for SSTR4 Gene

  • Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSTR4 Gene

SSTR4 (Somatostatin Receptor 4) is a Protein Coding gene. Diseases associated with SSTR4 include Gastric Leiomyosarcoma. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is SSTR1.

UniProtKB/Swiss-Prot for SSTR4 Gene

  • Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Tocris Summary for SSTR4 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR4 Gene

Genomics for SSTR4 Gene

Regulatory Elements for SSTR4 Gene

Enhancers for SSTR4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G023025 0.8 Ensembl 5.1 -9.7 -9686 0.2 ATF1 CREB3L1 TAL1 ETV1 CEBPG FOSL1 TCF12 ZNF366 NCOR1 TRIM24 SSTR4 LOC101929707 LOC100419956
GH20G023023 0.4 Ensembl 5 -11.5 -11486 0.2 CTCF RAD51 SSTR4 LOC101929707 LOC100419956
GH20G023380 0.6 FANTOM5 1.4 +345.0 345015 0.2 ESRRA CHD1 HMBOX1 HNF4A ZNF24 RBFOX2 NAPB SSTR4 RNA5SP479 GC20M023381 GZF1
GH20G023043 0.6 ENCODE 0.4 +8.2 8193 0.2 CTCF RAD51 TAL1 USF2 MNT RAD21 ZNF354B ZNF18 NXT1 ENSG00000234832 ENSG00000234646 GC20P023047 SSTR4
GH20G023046 0.6 ENCODE 0.4 +11.3 11283 0.2 CTBP1 PKNOX1 KLF9 FOS CUX1 DPF2 EP300 CD93 GC20P023047 SSTR4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSTR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSTR4 Gene

Chromosome:
20
Start:
23,035,386 bp from pter
End:
23,036,812 bp from pter
Size:
1,427 bases
Orientation:
Plus strand

Genomic View for SSTR4 Gene

Genes around SSTR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR4 Gene

Proteins for SSTR4 Gene

  • Protein details for SSTR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31391-SSR4_HUMAN
    Recommended name:
    Somatostatin receptor type 4
    Protein Accession:
    P31391
    Secondary Accessions:
    • Q17RM1
    • Q17RM3
    • Q9UIY1

    Protein attributes for SSTR4 Gene

    Size:
    388 amino acids
    Molecular mass:
    42003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSTR4 Gene

Post-translational modifications for SSTR4 Gene

  • Glycosylation at isoforms=24
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR4 Gene

Domains & Families for SSTR4 Gene

Gene Families for SSTR4 Gene

Suggested Antigen Peptide Sequences for SSTR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31391

UniProtKB/Swiss-Prot:

SSR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR4: view

Function for SSTR4 Gene

Molecular function for SSTR4 Gene

GENATLAS Biochemistry:
somatostatin receptor gene 4,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Gene Ontology (GO) - Molecular Function for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004994 somatostatin receptor activity TAS,IBA --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR4: view
genes like me logo Genes that share phenotypes with SSTR4: view

Animal Models for SSTR4 Gene

MGI Knock Outs for SSTR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SSTR4

CRISPR Products

miRNA for SSTR4 Gene

miRTarBase miRNAs that target SSTR4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSTR4
  • R&D Systems cDNA Clones for SSTR4 (Somatostatin R4/SSTR4)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR4 Gene

Localization for SSTR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSTR4 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8100352
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSTR4: view

Pathways & Interactions for SSTR4 Gene

genes like me logo Genes that share pathways with SSTR4: view

SIGNOR curated interactions for SSTR4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 9892014
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007268 chemical synaptic transmission IBA --
GO:0008285 negative regulation of cell proliferation TAS 9892014
genes like me logo Genes that share ontologies with SSTR4: view

Drugs & Compounds for SSTR4 Gene

(46) Drugs for SSTR4 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Octreotide Approved, Investigational Pharma Full agonist, Agonist sst2, sst3 and sst5 agonist 223
Pasireotide Approved Pharma 0
Somatostatin Approved Pharma Influences growth hormone release 237
BIM 23052 Pharma Full agonist, Agonist sst5 receptor agonist 0
Cyclosomatostatin Pharma somatostatin receptor antagonist, Non-selective sst receptor antagonist 0

(6) Additional Compounds for SSTR4 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta<sup>3</sup>-tetrapeptide
Full agonist, Agonist
CST-14
Full agonist, Agonist
H-c[Cys-Phe-LAgl(N<sup>beta</sup>Me,benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH
Full agonist, Agonist
H-c[Cys-Phe-LAgl(N<sup>beta</sup>Me,benzoyl)-Trp-Lys-Thr-Phe-Cys]-OH
Full agonist, Agonist
H-c[DCys-Phe-LAgl(N<sup>beta</sup>Me,benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH
Full agonist, Agonist

(5) Tocris Compounds for SSTR4 Gene

Compound Action Cas Number
Cyclosomatostatin Non-selective sst receptor antagonist 84211-54-1
CYN 154806 Selective sst2 antagonist 183658-72-2
L-803,087 trifluoroacetate Potent and selective sst4 agonist 217480-26-7
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Somatostatin Influences growth hormone release 51110-01-1

(15) ApexBio Compounds for SSTR4 Gene

Compound Action Cas Number
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 208706-12-1
BIM 23052 sst5 receptor agonist 133073-82-2
BIM 23056 Somatostatin receptor ligand 150155-61-6
CH 275 174688-78-9
Cortistatin 14 193829-96-8
Cyclosomatostatin somatostatin receptor antagonist 84211-54-1
CYN 154806 183658-72-2
L-803,087 trifluoroacetate 217480-26-7
L-817,818 217480-27-8
NNC 26-9100 199522-35-5
Octreotide acetate octapeptide congener of native somatostatin 83150-76-9
Pasireotide 396091-73-9
Seglitide 81377-02-8
Somatostatin 1-28 74315-46-1
TT 232 147159-51-1
genes like me logo Genes that share compounds with SSTR4: view

Transcripts for SSTR4 Gene

mRNA/cDNA for SSTR4 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSTR4
  • R&D Systems cDNA Clones for SSTR4 (Somatostatin R4/SSTR4)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR4 Gene

No ASD Table

Relevant External Links for SSTR4 Gene

GeneLoc Exon Structure for
SSTR4
ECgene alternative splicing isoforms for
SSTR4

Expression for SSTR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSTR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x7.1), Brain - Cerebellar Hemisphere (x5.7), Brain - Cortex (x5.6), Brain - Hippocampus (x5.6), Brain - Frontal Cortex (BA9) (x5.3), Brain - Amygdala (x4.8), and Brain - Cerebellum (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of SSTR4 Gene:

SSTR4

SOURCE GeneReport for Unigene cluster for SSTR4 Gene:

Hs.673846

mRNA Expression by UniProt/SwissProt for SSTR4 Gene:

P31391-SSR4_HUMAN
Tissue specificity: Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.

Evidence on tissue expression from TISSUES for SSTR4 Gene

  • Nervous system(2.9)
  • Lung(2.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SSTR4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSTR4 Gene

Orthologs for SSTR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR4 34 35
  • 98.88 (n)
mouse
(Mus musculus)
Mammalia Sstr4 34 16 35
  • 83.55 (n)
rat
(Rattus norvegicus)
Mammalia Sstr4 34
  • 81.94 (n)
chicken
(Gallus gallus)
Aves SSTR4 34
  • 76.74 (n)
SS4R 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496787 34
  • 69.63 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC557645 34
  • 64.98 (n)
BX324198.1 35
  • 59 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRSMS 34
  • 56.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 36 34
  • 53.95 (n)
Drostar1 36
  • 37 (a)
Species where no ortholog for SSTR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR4 Gene

ENSEMBL:
Gene Tree for SSTR4 (if available)
TreeFam:
Gene Tree for SSTR4 (if available)

Paralogs for SSTR4 Gene

Variants for SSTR4 Gene

Sequence variations from dbSNP and Humsavar for SSTR4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1001471509 -- 23,036,776(+) AGCCC(A/G)TGTAC intron-variant, downstream-variant-500B
rs1002549664 -- 23,035,284(+) AGCGG(G/T)GCGAG intron-variant, upstream-variant-2KB
rs1003531148 -- 23,033,972(+) ACTAT(G/T)GGGCT intron-variant, upstream-variant-2KB
rs1003933574 -- 23,035,281(+) CACAG(C/T)GGTGC intron-variant, upstream-variant-2KB
rs1004787848 -- 23,035,091(+) ACCCC(A/G)GGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSTR4 Gene

Variant ID Type Subtype PubMed ID
nsv520810 CNV loss 19592680
nsv524981 CNV loss 19592680

Variation tolerance for SSTR4 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSTR4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSTR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR4 Gene

Disorders for SSTR4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSTR4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gastric leiomyosarcoma
  • leiomyosarcoma of stomach
- elite association - COSMIC cancer census association via MalaCards
Search SSTR4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSTR4

Genetic Association Database (GAD)
SSTR4
Human Genome Epidemiology (HuGE) Navigator
SSTR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSTR4
genes like me logo Genes that share disorders with SSTR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSTR4 Gene

Publications for SSTR4 Gene

  1. Cloning and characterization of a fourth human somatostatin receptor. (PMID: 8483934) Rohrer L. … Schuele R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 64
  2. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. (PMID: 8100352) Demchyshyn L.L. … Niznik H.B. (Mol. Pharmacol. 1993) 3 4 22 64
  3. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PMID: 20634197) Canzian F. … Feigelson H.S. (Hum. Mol. Genet. 2010) 3 46 64
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  5. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PMID: 20810604) Gu F. … Kraft P. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64

Products for SSTR4 Gene

Sources for SSTR4 Gene

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