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Aliases for SSTR4 Gene

Aliases for SSTR4 Gene

  • Somatostatin Receptor 4 2 3 5
  • SS-4-R 3 4
  • SS4-R 3 4
  • SS4R 3 4
  • G-Protein Coupled Receptor 3

External Ids for SSTR4 Gene

Previous GeneCards Identifiers for SSTR4 Gene

  • GC20P023004
  • GC20P023011
  • GC20P022964

Summaries for SSTR4 Gene

Entrez Gene Summary for SSTR4 Gene

  • Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSTR4 Gene

SSTR4 (Somatostatin Receptor 4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for SSTR4 Gene

  • Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Tocris Summary for SSTR4 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR4 Gene

Genomics for SSTR4 Gene

Regulatory Elements for SSTR4 Gene

Enhancers for SSTR4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSTR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSTR4 Gene

Chromosome:
20
Start:
23,035,386 bp from pter
End:
23,036,812 bp from pter
Size:
1,427 bases
Orientation:
Plus strand

Genomic View for SSTR4 Gene

Genes around SSTR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR4 Gene

Proteins for SSTR4 Gene

  • Protein details for SSTR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31391-SSR4_HUMAN
    Recommended name:
    Somatostatin receptor type 4
    Protein Accession:
    P31391
    Secondary Accessions:
    • Q17RM1
    • Q17RM3
    • Q9UIY1

    Protein attributes for SSTR4 Gene

    Size:
    388 amino acids
    Molecular mass:
    42003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSTR4 Gene

Proteomics data for SSTR4 Gene at MOPED

Post-translational modifications for SSTR4 Gene

  • Glycosylation at Asn 24
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SSTR4 Gene

Domains & Families for SSTR4 Gene

Gene Families for SSTR4 Gene

Suggested Antigen Peptide Sequences for SSTR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31391

UniProtKB/Swiss-Prot:

SSR4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR4: view

Function for SSTR4 Gene

Molecular function for SSTR4 Gene

GENATLAS Biochemistry:
somatostatin receptor gene 4,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Gene Ontology (GO) - Molecular Function for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with SSTR4: view
genes like me logo Genes that share phenotypes with SSTR4: view

Animal Models for SSTR4 Gene

MGI Knock Outs for SSTR4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SSTR4

miRNA for SSTR4 Gene

miRTarBase miRNAs that target SSTR4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR4 Gene

Localization for SSTR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR4 Gene COMPARTMENTS Subcellular localization image for SSTR4 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with SSTR4: view

Pathways & Interactions for SSTR4 Gene

genes like me logo Genes that share pathways with SSTR4: view

SIGNOR curated interactions for SSTR4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 9892014
GO:0030900 forebrain development IEA --
GO:0038170 somatostatin signaling pathway IEA,TAS --
GO:0043410 positive regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with SSTR4: view

Drugs & Compounds for SSTR4 Gene

(33) Drugs for SSTR4 Gene - From: DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Octreotide Approved, Investigational Pharma Full agonist, Agonist sst2, sst3 and sst5 agonist 205
[<sup>125</sup>I]CGP 23996 Pharma Full agonist, Agonist 0
[<sup>125</sup>I]LTT-SRIF-28 Pharma Full agonist, Agonist 0
[<sup>125</sup>I]Tyr<sup>10</sup>-CST14 Pharma Full agonist, Agonist 0
[<sup>125</sup>I]Tyr<sup>11</sup>-SRIF-14 Pharma Full agonist, Agonist 0

(8) Additional Compounds for SSTR4 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta<sup>3</sup>-tetrapeptide
Full agonist, Agonist
CST-14
Full agonist, Agonist
H-c[Cys-Phe-LAgl(N<sup>beta</sup>Me,benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH
Full agonist, Agonist
H-c[Cys-Phe-LAgl(N<sup>beta</sup>Me,benzoyl)-Trp-Lys-Thr-Phe-Cys]-OH
Full agonist, Agonist
H-c[DCys-Phe-LAgl(N<sup>beta</sup>Me,benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH
Full agonist, Agonist

(5) Tocris Compounds for SSTR4 Gene

Compound Action Cas Number
L-803,087 trifluoroacetate Potent and selective sst4 agonist 217480-26-7
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Seglitide sst2 and sst5 agonist 81377-02-8
Somatostatin Influences growth hormone release 51110-01-1
Somatostatin 1-28 sst receptor agonist 74315-46-1
genes like me logo Genes that share compounds with SSTR4: view

Transcripts for SSTR4 Gene

mRNA/cDNA for SSTR4 Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR4 Gene

No ASD Table

Relevant External Links for SSTR4 Gene

GeneLoc Exon Structure for
SSTR4
ECgene alternative splicing isoforms for
SSTR4

Expression for SSTR4 Gene

mRNA expression in normal human tissues for SSTR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x7.1), Brain - Cerebellar Hemisphere (x5.7), Brain - Cortex (x5.6), Brain - Hippocampus (x5.6), Brain - Frontal Cortex (BA9) (x5.3), Brain - Amygdala (x4.8), and Brain - Cerebellum (x4.2).

SOURCE GeneReport for Unigene cluster for SSTR4 Gene Hs.673846

mRNA Expression by UniProt/SwissProt for SSTR4 Gene

P31391-SSR4_HUMAN
Tissue specificity: Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
genes like me logo Genes that share expression patterns with SSTR4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SSTR4 Gene

Orthologs for SSTR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR4 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sstr4 35
  • 83.55 (n)
  • 87.79 (a)
Sstr4 16
Sstr4 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSTR4 35
  • 98.88 (n)
  • 98.71 (a)
SSTR4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr4 35
  • 81.94 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves SSTR4 35
  • 76.74 (n)
  • 75.87 (a)
SS4R 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496787 35
  • 69.63 (n)
  • 73.37 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC557645 35
  • 64.98 (n)
  • 65.67 (a)
BX324198.1 36
  • 59 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 37
  • 38 (a)
Drostar1 37
  • 37 (a)
AlCR2 35
  • 53.95 (n)
  • 41.48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRSMS 35
  • 56.12 (n)
  • 41.73 (a)
Species with no ortholog for SSTR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR4 Gene

ENSEMBL:
Gene Tree for SSTR4 (if available)
TreeFam:
Gene Tree for SSTR4 (if available)

Paralogs for SSTR4 Gene

genes like me logo Genes that share paralogs with SSTR4: view

Variants for SSTR4 Gene

Sequence variations from dbSNP and Humsavar for SSTR4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_011703 -
VAR_021560 -
VAR_021561 -
VAR_049441 -

Structural Variations from Database of Genomic Variants (DGV) for SSTR4 Gene

Variant ID Type Subtype PubMed ID
nsv912816 CNV Gain 21882294
nsv524981 CNV Loss 19592680
nsv520810 CNV Loss 19592680

Variation tolerance for SSTR4 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.35; 85.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSTR4 Gene

HapMap Linkage Disequilibrium report
SSTR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR4 Gene

Disorders for SSTR4 Gene

Relevant External Links for SSTR4

Genetic Association Database (GAD)
SSTR4
Human Genome Epidemiology (HuGE) Navigator
SSTR4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSTR4

No disorders were found for SSTR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSTR4 Gene

Publications for SSTR4 Gene

  1. Cloning and characterization of a fourth human somatostatin receptor. (PMID: 8483934) Rohrer L. … Schuele R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 67
  2. Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment. (PMID: 19330452) Casarini A.P. … Bronstein M.D. (Pituitary 2009) 3 23
  3. C-tail mediated modulation of somatostatin receptor type-4 homo- and heterodimerizations and signaling. (PMID: 19426801) Somvanshi R.K. … Kumar U. (Cell. Signal. 2009) 3 23
  4. Expression of the somatostatin receptor subtype 4 in intact and inflamed pulmonary tissues. (PMID: 19687471) Varecza Z. … Helyes Z. (J. Histochem. Cytochem. 2009) 3 23
  5. The expression of somatostatin receptors 3, 4 and 5 in laryngeal pathology. (PMID: 18066572) Condon L.T. … Atkin S.L. (Eur Arch Otorhinolaryngol 2008) 3 23

Products for SSTR4 Gene

Sources for SSTR4 Gene

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