Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSTR4 Gene

Aliases for SSTR4 Gene

  • Somatostatin Receptor 4 2 3
  • SS-4-R 3 4
  • SS4-R 3 4
  • SS4R 3 4
  • Somatostatin Receptor Type 4 3
  • G-Protein Coupled Receptor 3

External Ids for SSTR4 Gene

Previous GeneCards Identifiers for SSTR4 Gene

  • GC20P023004
  • GC20P023011

Summaries for SSTR4 Gene

Entrez Gene Summary for SSTR4 Gene

  • Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSTR4 Gene

SSTR4 (Somatostatin Receptor 4) is a Protein Coding gene. Diseases associated with SSTR4 include pheochromocytoma and prostate cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for SSTR4 Gene

  • Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells

Tocris Summary for SSTR4 Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR4 Gene

Genomics for SSTR4 Gene

Regulatory Elements for SSTR4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSTR4 Gene

Start:
23,035,386 bp from pter
End:
23,036,812 bp from pter
Size:
1,427 bases
Orientation:
Plus strand

Genomic View for SSTR4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSTR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR4 Gene

Proteins for SSTR4 Gene

  • Protein details for SSTR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31391-SSR4_HUMAN
    Recommended name:
    Somatostatin receptor type 4
    Protein Accession:
    P31391
    Secondary Accessions:
    • Q17RM1
    • Q17RM3
    • Q9UIY1

    Protein attributes for SSTR4 Gene

    Size:
    388 amino acids
    Molecular mass:
    42003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSTR4 Gene

Proteomics data for SSTR4 Gene at MOPED

Post-translational modifications for SSTR4 Gene

  • Glycosylation at Asn24
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR4 Gene

Domains for SSTR4 Gene

Gene Families for SSTR4 Gene

HGNC:
  • SSTR :GPCR / Class A : Somatostatin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for SSTR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31391

UniProtKB/Swiss-Prot:

SSR4_HUMAN :
  • P31391
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR4: view

Function for SSTR4 Gene

Molecular function for SSTR4 Gene

GENATLAS Biochemistry: somatostatin receptor gene 4,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells

Gene Ontology (GO) - Molecular Function for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004994 somatostatin receptor activity IEA --
GO:0005515 protein binding --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR4: view
genes like me logo Genes that share phenotypes with SSTR4: view

Animal Models for SSTR4 Gene

MGI Knock Outs for SSTR4:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSTR4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SSTR4 Gene

Localization for SSTR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR4 Gene COMPARTMENTS Subcellular localization image for SSTR4 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8100352
GO:0016021 integral component of membrane --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with SSTR4: view

Pathways for SSTR4 Gene

genes like me logo Genes that share pathways with SSTR4: view

Pathways by source for SSTR4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SSTR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 9892014
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007268 synaptic transmission IBA --
GO:0008285 negative regulation of cell proliferation TAS 9892014
genes like me logo Genes that share ontologies with SSTR4: view

Compounds for SSTR4 Gene

(5) Tocris Compounds for SSTR4 Gene

Compound Action Cas Number
L-803,087 trifluoroacetate Potent and selective sst4 agonist [217480-26-7]
Cyclosomatostatin Non-selective sst receptor antagonist [84211-54-1]
CYN 154806 Selective sst2 antagonist [183658-72-2]
Somatostatin Influences growth hormone release [51110-01-1]
TC-G 1003 High affinity somatostatin sst2 receptor agonist [1021912-42-4]

(26) IUPHAR Ligand for SSTR4 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]LTT-SRIF-28 Agonist Full agonist 10.3
[125I]Tyr10-CST14 Agonist Full agonist 10.1
SRIF-14 Agonist Full agonist 10
CST-17 Agonist Full agonist 9.9
SRIF-28 Agonist Full agonist 9.9
CST-14 Agonist Full agonist 9.9
[125I]CGP 23996 Agonist Full agonist 9.8
BIM 23052 Agonist Full agonist 9.7
CGP 23996 Agonist Full agonist 9.3
L-803,087 Agonist Full agonist 9.2
[125I]Tyr11-SRIF-14 Agonist Full agonist 9
KE 108 Agonist Full agonist 8.8
BIM 23068 Agonist Full agonist 8.8
H-c[Cys-Phe-LAgl(NbetaMe,benzoyl)-Trp-Lys-Thr-Phe-Cys]-OH Agonist Full agonist 8.6
Des-AA5-[D-Trp8]SRIF Agonist Full agonist 8.5
H-c[DCys-Phe-LAgl(NbetaMe,benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH Agonist Full agonist 8.5
BIM 23295 Agonist Full agonist 8.5
H-c[Cys-Phe-LAgl(NbetaMe,benzoyl)-DTrp-Lys-Thr-Phe-Cys]-OH Agonist Full agonist 8.3
L-362,855 Agonist Full agonist 8.3
NNC269100 Agonist Full agonist 8.2
beta3-tetrapeptide Agonist Full agonist 7.8
BIM 23627 Antagonist Antagonist 7.4
BIM 23454 Antagonist Antagonist 7.3
PRL-2915 Antagonist Antagonist 7
[L-Tyr8]CYN 154806 Antagonist Antagonist 6.8
[D-Tyr8]CYN 154806 Antagonist Antagonist 6.7

(4) Novoseek inferred chemical compound relationships for SSTR4 Gene

Compound -log(P) Hits PubMed IDs
octreotide 74.2 2
lanreotide 60.7 1
ribonucleic acid 42 2
tyrosine 0 2
genes like me logo Genes that share compounds with SSTR4: view

Transcripts for SSTR4 Gene

mRNA/cDNA for SSTR4 Gene

(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSTR4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR4 Gene

No ASD Table

Relevant External Links for SSTR4 Gene

GeneLoc Exon Structure for
SSTR4
ECgene alternative splicing isoforms for
SSTR4

Expression for SSTR4 Gene

mRNA expression in normal human tissues for SSTR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR4 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (7.1), Brain - Cerebellar Hemisphere (5.7), Brain - Cortex (5.6), Brain - Hippocampus (5.6), Brain - Frontal Cortex (BA9) (5.3), Brain - Amygdala (4.8), and Brain - Cerebellum (4.2).

SOURCE GeneReport for Unigene cluster for SSTR4 Gene Hs.673846

mRNA Expression by UniProt/SwissProt for SSTR4 Gene

P31391-SSR4_HUMAN
Tissue specificity: Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals
genes like me logo Genes that share expressions with SSTR4: view

In Situ Assay Products

No data available for Protein expression for SSTR4 Gene

Orthologs for SSTR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR4 35
  • 98.88 (n)
  • 98.71 (a)
SSTR4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sstr4 35
  • 83.55 (n)
  • 87.79 (a)
Sstr4 16
Sstr4 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr4 35
  • 81.94 (n)
  • 87.5 (a)
chicken
(Gallus gallus)
Aves SS4R 36
  • 69 (a)
OneToOne
SSTR4 35
  • 76.74 (n)
  • 75.87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496787 35
  • 69.63 (n)
  • 73.37 (a)
zebrafish
(Danio rerio)
Actinopterygii BX324198.1 36
  • 59 (a)
ManyToMany
LOC557645 35
  • 64.98 (n)
  • 65.67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRSMS 35
  • 56.12 (n)
  • 41.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 35
  • 53.95 (n)
  • 41.48 (a)
Drostar1 37
  • 37 (a)
AlCR2 37
  • 38 (a)
Species with no ortholog for SSTR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR4 Gene

ENSEMBL:
Gene Tree for SSTR4 (if available)
TreeFam:
Gene Tree for SSTR4 (if available)

Paralogs for SSTR4 Gene

genes like me logo Genes that share paralogs with SSTR4: view

Variants for SSTR4 Gene

Sequence variations from dbSNP and Humsavar for SSTR4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1065191 - 23,035,731(+) TACCA(A/C)CATCT reference, missense
rs2268197 -- 23,033,822(+) TCTCT(C/G)TCTTA upstream-variant-2KB
rs2268198 -- 23,033,866(+) ACAAA(A/G)AGGAA upstream-variant-2KB
rs2268199 -- 23,034,455(+) CTCTC(A/G)ACCAC upstream-variant-2KB
rs2567607 -- 23,036,870(-) TCCAG(A/G)GGAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SSTR4 Gene

Variant ID Type Subtype PubMed ID
nsv912816 CNV Gain 21882294
nsv524981 CNV Loss 19592680
nsv520810 CNV Loss 19592680

Relevant External Links for SSTR4 Gene

HapMap Linkage Disequilibrium report
SSTR4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR4 Gene

Disorders for SSTR4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SSTR4 Gene including...

Search for SSTR4 Gene in MalaCards »

(8) Novoseek inferred disease relationships for SSTR4 Gene

Disease -log(P) Hits PubMed IDs
pituitary tumors 61.7 1
prolactinoma 56.5 1
adenoma 45.3 2
insulinoma 36.8 1
tumors 29 4

Relevant External Links for SSTR4

Genetic Association Database (GAD)
SSTR4
Human Genome Epidemiology (HuGE) Navigator
SSTR4
genes like me logo Genes that share disorders with SSTR4: view

No data available for UniProtKB/Swiss-Prot for SSTR4 Gene

Publications for SSTR4 Gene

  1. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. (PMID: 8100352) Demchyshyn L.L. … Niznik H.B. (Mol. Pharmacol. 1993) 3 4 23
  2. Cloning and characterization of a fourth human somatostatin receptor. (PMID: 8483934) Rohrer L. … Schuele R. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4
  3. Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. (PMID: 8512564) Xu Y. … Berelowitz M. (Biochem. Biophys. Res. Commun. 1993) 3 4
  4. Acromegaly: correlation between expression of somatostatin receptor subtypes and response to octreotide-lar treatment. (PMID: 19330452) Casarini A.P. … Bronstein M.D. (Pituitary 2009) 3 23
  5. C-tail mediated modulation of somatostatin receptor type-4 homo- and heterodimerizations and signaling. (PMID: 19426801) Somvanshi R.K. … Kumar U. (Cell. Signal. 2009) 3 23

Products for SSTR4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SSTR4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SSTR4
    • Block miRNA regulation of SSTR4 using miScript Target Protectors

    Sources for SSTR4 Gene

    Back to Top

    Content