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SSTR4 Gene

protein-coding   GIFtS: 62
GCID: GC20P022964

Somatostatin Receptor 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Somatostatin Receptor 41 2
SS-4-R2 3
SS4-R2 3
SS4R2 3
G-Protein Coupled Receptor2
Somatostatin Receptor Type 42

External Ids:    HGNC: 113331   Entrez Gene: 67542   Ensembl: ENSG000001326717   OMIM: 1824545   UniProtKB: P313913   

Export aliases for SSTR4 gene to outside databases

Previous GC identifers: GC20P023004 GC20P023011


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSTR4 Gene:
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic
effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a
tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and
is expressed in highest levels in fetal and adult brain and lung. (provided by RefSeq, Jul 2008)

GeneCards Summary for SSTR4 Gene:
SSTR4 (somatostatin receptor 4) is a protein-coding gene. Diseases associated with SSTR4 include sotos syndrome, and gigantism. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391
Function: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits
adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation
of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative
action of somatostatin in tumor cells

summary for SSTR4 Gene:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR4 (Somatostatin receptor 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SSTR4 gene promoter:
         p53   NF-kappaB   Meis-1b   FOXJ2 (long isoform)   Meis-1a   FOXJ2   NF-kappaB1   Pax-4a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSTR4 promoter sequence
   Search Chromatin IP Primers for SSTR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSTR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.2   Ensembl cytogenetic band:  20p11.21   HGNC chromosome: 20

SSTR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P022964:  view genomic region     (about GC identifiers)

Start:
23,016,057 bp from pter      End:
23,017,314 bp from pter
Size:
1,258 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391 (See protein sequence)
Recommended Name: Somatostatin receptor type 4  
Size: 388 amino acids; 42003 Da
Secondary accessions: Q17RM1 Q17RM3 Q9UIY1

Explore the universe of human proteins at neXtProt for SSTR4: NX_P31391

Explore proteomics data for SSTR4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn24

  • See SSTR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001043.2  
    ENSEMBL proteins: 
     ENSP00000255008  
    Reactome Protein details: P31391

    SSTR4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SSTR4

    SSTR4 Antibody Products:

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    SSTR4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript SSTR4-overexpressing Cell Line for Assay
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SSTR4
    Cloud-Clone Corp. CLIAs for SSTR4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SSTR: GPCR / Class A : Somatostatin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: sst4 receptor
    Somatostatin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000586 Somatstn_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001512 Somatstn_rcpt_4

    Graphical View of Domain Structure for InterPro Entry P31391

    ProtoNet protein and cluster: P31391

    2 Blocks protein domains:
    IPB000586 Somatostatin receptor signature
    IPB001512 Somatostatin receptor type 4 signature


    UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391
    Similarity: Belongs to the G-protein coupled receptor 1 family


    SSTR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSR4_HUMAN, P31391
    Function: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits
    adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation
    of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative
    action of somatostatin in tumor cells

         Genatlas biochemistry entry for SSTR4:
    somatostatin receptor gene 4,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004994somatostatin receptor activity IEA--
    GO:0005515protein binding ----
         
    SSTR4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SSTR4:
     Decreased number of cells in m  Decreased viability with pacli  Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sstr4):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  integument 
     no phenotypic analysis  respiratory system 

    SSTR4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sstr4tm1Ute for SSTR4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSTR4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSTR4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSTR4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSTR4

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSTR4

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SSTR4 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: SSTR4 (NM_001052)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSTR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SSTR4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSR4_HUMAN, P31391: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8100352
    GO:0016021integral component of membrane ----

    SSTR4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSTR4 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SSTR4
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for SSTR4
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for SSTR4):
        Neuroactive ligand-receptor interaction


    SSTR4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSTR4: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SSTR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSTR4 (P313913 ENSP000002550084) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    SSTP612783, ENSP000002876414I2D: score=1 STRING: ENSP00000287641
    DLG2Q157003, ENSP000003652724I2D: score=1 STRING: ENSP00000365272
    DLG4P783523I2D: score=2 
    ADCY2ENSP000003429524STRING: ENSP00000342952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS9892014
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8405411
    GO:0008285negative regulation of cell proliferation TAS9892014
    GO:0016477cell migration IEA--
    GO:0019369arachidonic acid metabolic process IEA--

    SSTR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SSTR4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    CYN 154806Selective sst2 antagonist[183658-72-2]
    (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Potent and selective sst2 agonist[208706-12-1]

    Selected IUPHAR Ligands for SSTR4 (sst4 receptor) (see all 26)    About this table
    LigandTypeActionAffinityPubmed IDs
    CST-17
    AgonistFull agonist8.5 - 9.69650799 10598788
    [125I]LTT-SRIF-28
    AgonistFull agonist9.69650799
    [125I]CGP 23996
    AgonistFull agonist9.410598788
    [125I]Tyr10-CST14
    AgonistFull agonist9.410598788
    SRIF-14
    AgonistFull agonist8.4 - 9.315333679 10598788 11520208 9724791 9784130 9650799 9600011 8769372 7988476
    L-803,087
    AgonistFull agonist9.29784130
    SRIF-28
    AgonistFull agonist8.1 - 9.215333679 7988476 10598788 8769372 9650799 9600011
    [125I]Tyr11-SRIF-14
    AgonistFull agonist98483934
    Des-AA5-[D-Trp8]SRIF
    AgonistFull agonist8.7 - 8.915658864
    CGP 23996
    AgonistFull agonist8.6 - 8.89650799 10598788

    4 Novoseek inferred chemical compound relationships for SSTR4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 74.2 2 7628822 (1), 8961800 (1)
    lanreotide 60.7 1 7628822 (1)
    ribonucleic acid 42 2 7775631 (1), 7521350 (1)
    tyrosine 0 3 7674817 (1), 16488965 (1)



    SSTR4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SSTR4 gene: 
    NM_001052.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000255008(uc002wsr.2)

    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSTR4
      QuantiTect SYBR Green Assays in human, mouse, rat SSTR4
      QuantiFast Probe-based Assays in human, mouse, rat SSTR4

    3 AceView cDNA sequences:

    BV184553 BC069063 NM_001052 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSTR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCCCCAC
    SSTR4 Expression
    About this image


    SSTR4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    SSTR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSTR4 Protein Expression

    UniProtKB/Swiss-Prot: SSR4_HUMAN, P31391
    Tissue specificity: Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser
    quantities in the kidney, pituitary and adrenals

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSTR4: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SSTR4
    OriGene qSTAR qPCR primer pairs in human, mouse for SSTR4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSTR4
    QuantiTect SYBR Green Assays in human, mouse, rat SSTR4
    QuantiFast Probe-based Assays in human, mouse, rat SSTR4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SSTR4 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sstr41 , 5 somatostatin receptor 41, 5 83.55(n)1
    87.79(a)1
      2 (73.44 cM)5
    206081  NM_009219.31  NP_033245.21 
     1483953445 
    chicken
    (Gallus gallus)
    Aves SSTR41 somatostatin receptor 4 76.74(n)
    75.87(a)
      428547  NM_001031518.1  NP_001026689.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004967871 somatostatin receptor type 4-like 69.63(n)
    73.37(a)
      100496787  XM_004914729.1  XP_004914786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5576451 somatostatin receptor type 1-like 64.98(n)
    65.67(a)
      557645  XM_005172218.1  XP_005172275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AlCR21 , 3 G-protein coupled receptor protein
    signaling pathway more3
    allatostatin C receptor 21
    38(a)
    (best of 2)3
    53.95(n)1
    41.48(a)1
      75D13
    400191  NM_001275086.11  NP_001262015.11 


    ENSEMBL Gene Tree for SSTR4 (if available)
    TreeFam Gene Tree for SSTR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSTR4 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for SSTR4 using alignment to 1 protein entry:     SSR4_HUMAN(see all similar genes):
    SSTR2    SSTR1    SSTR5    OPRL1    SSTR3    OPRM1
    NPBWR2    OPRD1    OPRK1    GPR24    CXCR6    CXCR1
    NPBWR1    CCR2    BLR1    CXCR2    CXCR5    IL8RB

    SSTR4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSTR4 (see all 154)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs355528621,2
    C,F--23014126(+) CAGGAA/GAGATT 1 -- us2k15Minor allele frequency- G:0.01NA EU CSAM EA 380
    rs1385416871,2
    C--23014128(+) GGAAAG/TATTCC 1 -- us2k10--------
    rs1411281811,2
    --23014192(+) GGGGCC/TGAGTG 1 -- us2k10--------
    rs1891894551,2
    --23014228(+) AGAGAA/GGAGAC 1 -- us2k10--------
    rs1812449031,2
    --23014244(+) AGACAA/CGATAG 1 -- us2k10--------
    rs340033091,2
    C,F--23014355(+) CTCTTC/TCCTCC 1 -- us2k15Minor allele frequency- T:0.00NA EU CSAM EA 380
    rs72669931,2
    C,F--23014447(+) CTCAGG/CGAAGG 1 -- us2k15Minor allele frequency- C:0.00NA EU CSAM EA 380
    rs359024921,2
    C,F--23014450(+) AGGGAA/TGGGTC 1 -- us2k17Minor allele frequency- T:0.04NA EU CSAM EA WA 500
    rs343076151,2
    C,F--23014453(+) GAAGGG/ATCTCT 1 -- us2k17Minor allele frequency- A:0.05NA EU CSAM EA WA 500
    rs1494905321,2
    --23014457(+) GGTCTC/TTCTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SSTR4 (23016057 - 23017314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SSTR4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520810CNV Loss19592680
    nsv524981CNV Loss19592680
    nsv912816CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSTR4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 182454    OMIM disorders: --

    Selected diseases for SSTR4 (see all 31):    
    About MalaCards
    sotos syndrome    gigantism    functioning pituitary adenoma    non-functioning pituitary adenoma
    pancreatic endocrine tumors    prolactinoma    somatostatin analog    insulinoma
    pheochromocytoma    pituitary tumors    pituitary adenoma    acromegaly
    neuroendocrine tumor    adenoma    graves' disease    laryngitis
    prostate cancer    hepatitis b    prostatitis    cerebritis


    SSTR4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for SSTR4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary tumors 61.7 1 7521350 (1)
    prolactinoma 56.5 1 7521350 (1)
    adenoma 45.3 2 8866248 (1), 7521350 (1)
    insulinoma 36.8 2 8132773 (1)
    tumors 29 5 10768564 (1), 17218727 (1), 8961800 (1), 7521350 (1)
    pheochromocytoma 21.5 2 7775631 (2)
    carcinoma 12.3 2 12210479 (1)
    prostate cancer 0 5 9253335 (2), 12210479 (2)

    Genetic Association Database (GAD): SSTR4
    Human Genome Epidemiology (HuGE) Navigator: SSTR4 (7 documents)

    Export disorders for SSTR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSTR4 gene, integrated from 10 sources (see all 81):
    (articles sorted by number of sources associating them with SSTR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a fourth human somatostatin receptor. (PubMed id 8483934)1, 2, 3 Rohrer L....Schuele R. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. (PubMed id 8100352)1, 2, 9 Demchyshyn L.L.... Niznik H.B. (Mol. Pharmacol. 1993)
    3. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    5. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. (PubMed id 19423539)1, 4 Johansson M....Kaaks R. (amp 2009)
    8. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4 Canzian F....Kaaks R. (amp 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6754 HGNC: 11333 AceView: SSTR4 Ensembl:ENSG00000132671 euGenes: HUgn6754
    ECgene: SSTR4 Kegg: 6754 H-InvDB: SSTR4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SSTR4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSTR4 gene:
    Search GeneIP for patents involving SSTR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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