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Aliases for SSTR3 Gene

Aliases for SSTR3 Gene

  • Somatostatin Receptor 3 2 3
  • SS-3-R 3 4
  • SSR-28 3 4
  • SS3-R 3 4
  • SS3R 3 4
  • Somatostatin Receptor Type 3 3

External Ids for SSTR3 Gene

Summaries for SSTR3 Gene

Entrez Gene Summary for SSTR3 Gene

  • This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for SSTR3 Gene

SSTR3 (Somatostatin Receptor 3) is a Protein Coding gene. Diseases associated with SSTR3 include oncogenic osteomalacia and vipoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include somatostatin receptor activity.

UniProtKB/Swiss-Prot for SSTR3 Gene

  • Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

Tocris Summary for SSTR3 Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the voltage sensor and is activated by changes in membrane potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR3 Gene

Genomics for SSTR3 Gene

Genomic Location for SSTR3 Gene

Start:
37,204,237 bp from pter
End:
37,220,438 bp from pter
Size:
16,202 bases
Orientation:
Minus strand

Genomic View for SSTR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR3 Gene

Regulatory Elements for SSTR3 Gene

Proteins for SSTR3 Gene

  • Protein details for SSTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32745-SSR3_HUMAN
    Recommended name:
    Somatostatin receptor type 3
    Protein Accession:
    P32745
    Secondary Accessions:
    • A8K550
    • Q53ZR7

    Protein attributes for SSTR3 Gene

    Size:
    418 amino acids
    Molecular mass:
    45847 Da
    Quaternary structure:
    • Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function (By similarity).

neXtProt entry for SSTR3 Gene

Proteomics data for SSTR3 Gene at MOPED

Post-translational modifications for SSTR3 Gene

  • Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSTR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR3 Gene

Domains for SSTR3 Gene

Gene Families for SSTR3 Gene

HGNC:
  • SSTR :GPCR / Class A : Somatostatin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for SSTR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32745

UniProtKB/Swiss-Prot:

SSR3_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P32745
genes like me logo Genes that share domains with SSTR3: view

Function for SSTR3 Gene

Molecular function for SSTR3 Gene

GENATLAS Biochemistry: somatostatin receptor gene 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for SSTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004994 somatostatin receptor activity IEA --
GO:0005515 protein binding IPI 19071123
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR3: view
genes like me logo Genes that share phenotypes with SSTR3: view

Animal Models for SSTR3 Gene

MGI Knock Outs for SSTR3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SSTR3 Gene

Localization for SSTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR3 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR3 Gene COMPARTMENTS Subcellular localization image for SSTR3 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1337145
GO:0005929 cilium --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SSTR3: view

Pathways for SSTR3 Gene

genes like me logo Genes that share pathways with SSTR3: view

Pathways by source for SSTR3 Gene

Gene Ontology (GO) - Biological Process for SSTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007218 neuropeptide signaling pathway IBA --
GO:0007267 cell-cell signaling TAS 1337145
genes like me logo Genes that share ontologies with SSTR3: view

Compounds for SSTR3 Gene

(5) Tocris Compounds for SSTR3 Gene

Compound Action Cas Number
(1R,1S,3R/1R,1R,3S)-L-054,264 Potent and selective sst2 agonist [208706-12-1]
Cyclosomatostatin Non-selective sst receptor antagonist [84211-54-1]
CYN 154806 Selective sst2 antagonist [183658-72-2]
Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
Somatostatin Influences growth hormone release [51110-01-1]

(1) Drugbank Compounds for SSTR3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pasireotide
396091-73-9 target

(49) IUPHAR Ligand for SSTR3 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]LTT-SRIF-28 Agonist Full agonist 10.3
[125I]Tyr10-CST14 Agonist Full agonist 10.1
SRIF-14 Agonist Full agonist 10
NC 8-12 Agonist Full agonist 10
SRIF-28 Agonist Full agonist 9.9
CST-14 Agonist Full agonist 9.9
CST-17 Agonist Full agonist 9.9
[125I]CGP 23996 Agonist Full agonist 9.8
BIM 23052 Agonist Full agonist 9.7
[125I]Tyr7-Sst3-ODN-8 Agonist Full agonist 9.6
CGP 23996 Agonist Full agonist 9.3
BN-81,644 Agonist Full agonist 9.2
BN-81,674 Agonist Full agonist 9
KE 108 Agonist Full agonist 8.8
BIM 23058 Agonist Full agonist 8.8
SOM-230 Agonist Full agonist 8.8
BIM 23068 Agonist Full agonist 8.8
octreotide Agonist Full agonist 8.6
Des-AA5-[D-Trp8]SRIF Agonist Full agonist 8.5
L-362,855 Agonist Full agonist 8.3
[111In]DOTA-BOC-ATE Agonist Full agonist 8.3
sst3-ODN-8 Antagonist Antagonist 8.2
BIM 23023 Agonist Full agonist 8.1
BIM 23034 Agonist Full agonist 8.1
[111In]DOTA-NOC Agonist Full agonist 8.1
lanreotide Agonist Full agonist 8
NC 4-28B Agonist Full agonist 8
vapreotide Agonist Full agonist 7.9
[111In]DOTA-NOC-ATE Agonist Full agonist 7.9
MK-678 Agonist Full agonist 7.9
NVP ACQ090 Antagonist Antagonist 7.9
BIM 23030 Agonist Full agonist 7.8
BIM 23050 Agonist Full agonist 7.8
[111In,90Y]DOTA-NOC Agonist Full agonist 7.6
BIM 23197 Agonist Full agonist 7.6
[111In,90Y]DOTA-OC Agonist Full agonist 7.6
L-796,778 Agonist Full agonist 7.6
BOC-ATE Agonist Full agonist 7.5
BIM 23627 Antagonist Antagonist 7.4
BIM 23454 Antagonist Antagonist 7.3
BIM 23056 Agonist Full agonist 7.2
L-363,301 Agonist Full agonist 7
PRL-2915 Antagonist Antagonist 7
PRL-2970 Antagonist Antagonist 7
[L-Tyr8]CYN 154806 Antagonist Antagonist 6.8
[D-Tyr8]CYN 154806 Antagonist Antagonist 6.7
NOC-ATE Agonist Full agonist 6.5
[111In,90Y]DOTA-LAN Agonist Full agonist 6.5
[111In,90Y]DOTA-TOC Agonist Full agonist 6.4

(1) Novoseek inferred chemical compound relationships for SSTR3 Gene

Compound -log(P) Hits PubMed IDs
octreotide 82.9 5
genes like me logo Genes that share compounds with SSTR3: view

Transcripts for SSTR3 Gene

mRNA/cDNA for SSTR3 Gene

Unigene Clusters for SSTR3 Gene

Somatostatin receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR3 Gene

No ASD Table

Relevant External Links for SSTR3 Gene

GeneLoc Exon Structure for
SSTR3
ECgene alternative splicing isoforms for
SSTR3

Expression for SSTR3 Gene

mRNA expression in normal human tissues for SSTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR3 Gene

This gene is overexpressed in Brain - Cortex (6.2), Testis (6.1), and Brain - Frontal Cortex (BA9) (5.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SSTR3 Gene

SOURCE GeneReport for Unigene cluster for SSTR3 Gene Hs.225995

mRNA Expression by UniProt/SwissProt for SSTR3 Gene

P32745-SSR3_HUMAN
Tissue specificity: Brain, pituitary and pancreas.
genes like me logo Genes that share expressions with SSTR3: view

Orthologs for SSTR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR3 35
  • 99.2 (n)
  • 99.52 (a)
cow
(Bos Taurus)
Mammalia SSTR3 35
  • 87.2 (n)
  • 89.13 (a)
dog
(Canis familiaris)
Mammalia SSTR3 35
  • 89.93 (n)
  • 89.93 (a)
mouse
(Mus musculus)
Mammalia Sstr3 35
  • 83.46 (n)
  • 87.04 (a)
Sstr3 16
rat
(Rattus norvegicus)
Mammalia Sstr3 35
  • 82.72 (n)
  • 87.53 (a)
chicken
(Gallus gallus)
Aves SSTR3 35
  • 72.15 (n)
  • 73.78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr3 35
  • 58.73 (n)
  • 62.04 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334518 35
  • 62.16 (n)
  • 66.67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Drostar1 37
  • 40 (a)
AlCR2 37
  • 38 (a)
Species with no ortholog for SSTR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR3 Gene

ENSEMBL:
Gene Tree for SSTR3 (if available)
TreeFam:
Gene Tree for SSTR3 (if available)

Paralogs for SSTR3 Gene

Selected SIMAP similar genes for SSTR3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSTR3: view

No data available for Paralogs for SSTR3 Gene

Variants for SSTR3 Gene

Sequence variations from dbSNP and Humsavar for SSTR3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs69264 -- 37,207,911(+) ATGCC(A/G)AACCT intron-variant
rs86582 -- 37,207,351(+) CGGGC(C/T)GAGCG synonymous-codon, reference
rs86583 -- 37,207,705(-) TCGGC(A/G)GGCCC synonymous-codon, reference
rs229565 -- 37,204,314(-) TAGAA(G/T)GGTCC utr-variant-3-prime
rs229566 -- 37,206,091(-) TAACC(C/T)GGTGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SSTR3 Gene

Variant ID Type Subtype PubMed ID
nsv829203 CNV Loss 20364138
nsv915019 CNV Loss 21882294
nsv915020 CNV Loss 21882294
nsv834188 CNV Loss 17160897

Relevant External Links for SSTR3 Gene

HapMap Linkage Disequilibrium report
SSTR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR3 Gene

Disorders for SSTR3 Gene

(1) University of Copenhagen DISEASES for SSTR3 Gene

(12) Novoseek inferred disease relationships for SSTR3 Gene

Disease -log(P) Hits PubMed IDs
pituitary adenoma 69.1 2
prolactinoma 62.9 1
pituitary tumors 56.2 1
adenoma 42.4 4
insulinoma 41.5 2

Relevant External Links for SSTR3

Genetic Association Database (GAD)
SSTR3
Human Genome Epidemiology (HuGE) Navigator
SSTR3
genes like me logo Genes that share disorders with SSTR3: view

No data available for UniProtKB/Swiss-Prot for SSTR3 Gene

Publications for SSTR3 Gene

  1. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. (PMID: 1337145) Yamada Y. … Seino S. (Mol. Endocrinol. 1992) 3 4 23
  2. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. (PMID: 8097479) Corness J.D. … Niznik H.B. (FEBS Lett. 1993) 3 4 23
  3. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PMID: 8449518) Yamada Y. … Bell G.I. (Genomics 1993) 2 3 23
  4. Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization. (PMID: 9295322) Roth A. … Richter D. (J. Biol. Chem. 1997) 3 23
  5. Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3. (PMID: 11472428) Talme T. … Sundqvist K.G. (Clin. Exp. Immunol. 2001) 3 23

Products for SSTR3 Gene

  • antibodies-online proteins for SSTR3
  • antibodies-online antibodies for SSTR3
  • antibodies-online kits for SSTR3

Sources for SSTR3 Gene

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