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SSTR3 Gene

protein-coding   GIFtS: 68
GCID: GC22M037600

Somatostatin Receptor 3

  See SSTR3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Somatostatin Receptor 31 2
SS-3-R2 3
SS3-R2 3
SS3R2 3
SSR-282 3
Somatostatin Receptor Type 32

External Ids:    HGNC: 113321   Entrez Gene: 67532   Ensembl: ENSG000001834737   OMIM: 1824535   UniProtKB: P327453   

Export aliases for SSTR3 gene to outside databases

Previous GC identifers: GC22M034217 GC22M035845 GC22M035926 GC22M020567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSTR3 Gene:
This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that
regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as
well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms
of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled
somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and
heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor
tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in
multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for SSTR3 Gene:
SSTR3 (somatostatin receptor 3) is a protein-coding gene. Diseases associated with SSTR3 include oncogenic osteomalacia, and vipoma. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is OPRL1.

UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745
Function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins
to inhibition of adenylyl cyclase

summary for SSTR3 Gene:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR3 (Somatostatin receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSTR3 gene promoter:
         AhR   NF-1   NF-1/L   Tal-1   p53   E47   GATA-2   HEN1   AREB6   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSTR3 promoter sequence
   Search Chromatin IP Primers for SSTR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSTR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

SSTR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M037600:  view genomic region     (about GC identifiers)

Start:
37,600,278 bp from pter      End:
37,608,362 bp from pter
Size:
8,085 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745 (See protein sequence)
Recommended Name: Somatostatin receptor type 3  
Size: 418 amino acids; 45847 Da
Subunit: Homodimer and heterodimer with SSTR2. Heterodimerization with SSTR2 inactivates SSTR3 receptor function
(By similarity)
Secondary accessions: A8K550 Q53ZR7

Explore the universe of human proteins at neXtProt for SSTR3: NX_P32745

Explore proteomics data for SSTR3 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation increases upon somatostatin binding (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SSTR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001042.1  NP_001265616.1  

    ENSEMBL proteins: 
     ENSP00000330138   ENSP00000384904  
    Reactome Protein details: P32745

    SSTR3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SSTR3
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    Novus Biologicals SSTR3 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSTR3

     
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    SSTR3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SSTR3
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    Cloud-Clone Corp. ELISAs for SSTR3
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    Search eBioscience for ELISAs for SSTR3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SSTR: GPCR / Class A : Somatostatin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: sst3 receptor
    Somatostatin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000586 Somatstn_rcpt
     IPR001856 Somatstn_rcpt_3
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P32745

    ProtoNet protein and cluster: P32745

    2 Blocks protein domains:
    IPB000586 Somatostatin receptor signature
    IPB001856 Somatostatin receptor type 3 signature


    UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with SSTR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSR3_HUMAN, P32745
    Function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins
    to inhibition of adenylyl cyclase

         Genatlas biochemistry entry for SSTR3:
    somatostatin receptor gene 3,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004994somatostatin receptor activity IEA--
    GO:0005515protein binding IPI19071123
         
    Find genes that share ontologies with SSTR3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SSTR3:
     Decreased G3BP1 protein expres  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sstr3):
     no phenotypic analysis 

    Find genes that share phenotypes with SSTR3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sstr3tm1Ute for SSTR3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSTR3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSTR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSTR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSTR3

    miRNA
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    hsa-miR-125a-5p hsa-miR-670 hsa-miR-125b hsa-miR-377 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidSSTR3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSTR3

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    GenScript: all cDNA clones in your preferred vector: SSTR3 (NM_001051)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR3

    Cell Line
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10749) for SSTR3 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSR3_HUMAN, P32745: Cell membrane; Multi-pass membrane protein (By similarity). Note=Internalized into
    endoplasmic vesicles upon somatostatin-stimulation (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1337145
    GO:0005929cilium ----
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SSTR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSTR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90


    Find genes that share SuperPaths with SSTR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SSTR3
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for SSTR3
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for SSTR3):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSTR3: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SSTR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSTR3 (P327451, 2, 3 ENSP000003301384) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MPDZO759701, 2, 3, ENSP000003704104EBI-6266935,EBI-821405 MINT-6800756 MINT-6800770 MINT-6800562 MINT-6800607 MINT-6801122 I2D: score=1 STRING: ENSP00000370410
    SSTP612783, ENSP000002876414I2D: score=2 STRING: ENSP00000287641
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    GNAI1P630963, ENSP000003430274I2D: score=1 STRING: ENSP00000343027
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    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8405411
    GO:0007267cell-cell signaling TAS1337145
    GO:0007283spermatogenesis IEA--
    GO:0008285negative regulation of cell proliferation TAS8961277

    Find genes that share ontologies with SSTR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SSTR3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    CYN 154806Selective sst2 antagonist[183658-72-2]
    (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Potent and selective sst2 agonist[208706-12-1]

    1 DrugBank Compound for SSTR3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pasireotide-- 396091-73-9target--17395978 11980628

    Selected IUPHAR Ligands for SSTR3 (sst3 receptor) (see all 49)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]LTT-SRIF-28
    AgonistFull agonist9.7 - 10.39650799 10598788 8097479
    [125I]Tyr10-CST14
    AgonistFull agonist10.19650799 10598788
    SRIF-14
    AgonistFull agonist8.7 - 1015333679 10598788 11520208 9724791 8097479 9784130 9650799 8769372 7988476
    NC 8-12
    AgonistFull agonist107988476
    SRIF-28
    AgonistFull agonist8.1 - 9.915333679 7988476 10598788 8097479 9650799 9600011 8769372
    CST-14
    AgonistFull agonist9.1 - 9.99650799 10598788
    CST-17
    AgonistFull agonist8.7 - 9.99650799 15333679 10598788
    [125I]CGP 23996
    AgonistFull agonist9.810598788
    BIM 23052
    AgonistFull agonist8.4 - 9.79650799 10598788 8769372
    [125I]Tyr7-Sst3-ODN-8
    AgonistFull agonist9.611095748

    1 Novoseek inferred chemical compound relationship for SSTR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 82.9 7 15197339 (2), 15326367 (1), 16625842 (1), 9744346 (1)



    Find genes that share compounds with SSTR3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSTR3 gene (2 alternative transcripts): 
    NM_001051.4  NM_001278687.2  

    Unigene Cluster for SSTR3:

    Somatostatin receptor 3
    Hs.225995  [show with all ESTs]
    Unigene Representative Sequence: AK291165
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328544(uc003ara.3 uc003arb.3) ENST00000402501
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSSTR3 3' UTR sequence
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    Flow Cytometry
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    Additional mRNA sequence: 

    AK291165.1 BC042068.1 BC096829.1 CR456585.1 

    1 DOTS entry:

    DT.65284413 

    19 AceView cDNA sequences:

    BX281894 AW453011 CR456585 NM_001051 AW028270 AI475600 CA772710 BU584980 
    BF434297 BF515539 BV196234 BV198331 BC042068 CF147825 BU584704 BF513812 
    BI828469 BM805640 CA771848 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSTR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGATGTT
    SSTR3 Expression
    About this image


    SSTR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
     
     Skeletal Muscle (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
    SSTR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSTR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.225995

    UniProtKB/Swiss-Prot: SSR3_HUMAN, P32745
    Tissue specificity: Brain, pituitary and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSTR3: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Primary Cilia in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SSTR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSTR3
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    QuantiFast Probe-based Assays in human, mouse, rat SSTR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SSTR3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sstr31 , 5 somatostatin receptor 31, 5 83.46(n)1
    87.04(a)1
      15 (37.55 cM)5
    206071  NM_009218.31  NP_033244.21 
     785370155 
    chicken
    (Gallus gallus)
    Aves SSTR31 somatostatin receptor 3 72.15(n)
    73.78(a)
      427907  NM_001024583.1  NP_001019754.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSTR36
    somatostatin receptor 3
    68(a)
    1 ↔ 1
    5(22844936-22846168)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sstr31 somatostatin receptor 3 58.73(n)
    62.04(a)
      100488886  XM_004913888.1  XP_004913945.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003345181 somatostatin receptor type 3-like 62.16(n)
    66.67(a)
      100334518  XM_003201636.2  XP_003201684.1 


    ENSEMBL Gene Tree for SSTR3 (if available)
    TreeFam Gene Tree for SSTR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSTR3 gene
    OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  GALR22  
    SSTR52  MCHR22  SSTR12  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for SSTR3 using alignment to 1 protein entry:     SSR3_HUMAN(see all similar genes):
    SSTR2    SSTR5    SSTR1    SSTR4    NPBWR1    OPRM1
    OPRD1    OPRK1    GALR1    NPBWR2    BLR1    CXCR5
    OPRL1    APLNR    CXCR6    GALR2    AGTR1    GPR24

    Find genes that share paralogs with SSTR3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSTR3 (see all 279)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2013843871,2
    Cuntested137603112(+) GGCACA/GAGGGT 2 S L mis10--------
    rs358095251,2
    C,F--37601957(-) CTCCTG/CGACGG 1 -- ds50015Minor allele frequency- C:0.03NA EU CSAM EA 380
    rs2295661,2
    C,F,A,H--37602131(-) TAACCC/TGGTGG 1 -- ds500126Minor allele frequency- T:0.37MN NS EA NA EU CSAM WA 2900
    rs81422551,2
    C,F,H--37602248(+) TCTAGT/CTGATG 1 -- ut3110Minor allele frequency- C:0.04NS EA NA WA 1372
    rs81413121,2
    C,F--37602304(+) TTTTGC/TCTGCT 1 -- ut316Minor allele frequency- T:0.02NA EU CSAM EA WA 498
    rs1920180541,2
    --37602396(+) GTCACA/CGAGGA 1 -- ut310--------
    rs2295671,2
    C,F,A,H--37602446(-) ttgctG/Atgtga 1 -- ut31 ese321Minor allele frequency- A:0.29NS EA NA EU CSAM WA 1898
    rs2015912831,2
    --37602543(+) CCCACA/GGCTTC 1 -- ut310--------
    rs114067611,2
    C--37602583(+) CCAGGC/-CCCTA 1 -- ut312Minor allele frequency- -:0.00NA CSA 6
    rs49884711,2,,4
    C,F,H--37602602(-) GATGCG/ACATCA 2 /H /R mis1 ese312Minor allele frequency- A:0.01NA EU CSAM EA NS WA 5440

    HapMap Linkage Disequilibrium report for SSTR3 (37600278 - 37608362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SSTR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv915020CNV Loss21882294
    nsv829203CNV Loss20364138
    nsv834188CNV Loss17160897
    nsv915019CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSTR3
    DNA2.0 Custom Variant and Variant Library Synthesis for SSTR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182453    OMIM disorders: --

    3 diseases for SSTR3:    
    About MalaCards
    oncogenic osteomalacia    vipoma    pituitary adenoma

    1 disease from the University of Copenhagen DISEASES database for SSTR3:
    Adenoma

    Find genes that share disorders with SSTR3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SSTR3 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma 69.1 3 12721506 (1), 7521350 (1)
    prolactinoma 62.9 1 7521350 (1)
    pituitary tumors 56.2 1 7521350 (1)
    adenoma 42.4 6 8866248 (1), 7714115 (1), 11415850 (1), 17420609 (1)
    insulinoma 41.5 4 8132773 (1), 7714115 (1)
    adenocarcinoma gastric 41.1 2 15197339 (1), 15326367 (1)
    tumors 34.3 22 8012966 (3), 19330452 (2), 8515684 (2), 10768564 (1) (see all 13)
    carcinoid 31.1 1 16508627 (1)
    gastric cancer 11 18 15197339 (6), 17683502 (5), 17679363 (1)
    primary tumor 0 1 8012966 (1)

    Genetic Association Database (GAD): SSTR3
    Human Genome Epidemiology (HuGE) Navigator: SSTR3 (13 documents)

    Export disorders for SSTR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSTR3 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with SSTR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. (PubMed id 1337145)1, 2, 9 Yamada Y.... Seino S. (Mol. Endocrinol. 1992)
    2. A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. (PubMed id 8097479)1, 2, 9 Corness J.D.... Niznik H.B. (FEBS Lett. 1993)
    3. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PubMed id 8449518)1, 3, 9 Yamada Y....Bell G.I. (Genomics 1993)
    4. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    5. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    6. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    7. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    8. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    9. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)
    10. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6753 HGNC: 11332 AceView: SSTR3 Ensembl:ENSG00000183473 euGenes: HUgn6753
    ECgene: SSTR3 Kegg: 6753 H-InvDB: SSTR3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SSTR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSTR3 gene:
    Search GeneIP for patents involving SSTR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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