Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSTR2 Gene

Aliases for SSTR2 Gene

  • Somatostatin Receptor 2 2 3
  • SRIF-1 3 4
  • SS2R 3 4
  • Somatostatin Receptor Type 2 3
  • SS-2-R 4
  • SS2-R 4

External Ids for SSTR2 Gene

Summaries for SSTR2 Gene

Entrez Gene Summary for SSTR2 Gene

  • Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSTR2 Gene

SSTR2 (Somatostatin Receptor 2) is a Protein Coding gene. Diseases associated with SSTR2 include type c thymoma and pancreatic endocrine carcinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include PDZ domain binding and somatostatin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for SSTR2 Gene

  • Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Tocris Summary for SSTR2 Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the voltage sensor and is activated by changes in membrane potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR2 Gene

Genomics for SSTR2 Gene

Genomic Location for SSTR2 Gene

Start:
73,165,012 bp from pter
End:
73,176,633 bp from pter
Size:
11,622 bases
Orientation:
Plus strand

Genomic View for SSTR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR2 Gene

Regulatory Elements for SSTR2 Gene

Proteins for SSTR2 Gene

  • Protein details for SSTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30874-SSR2_HUMAN
    Recommended name:
    Somatostatin receptor type 2
    Protein Accession:
    P30874
    Secondary Accessions:
    • A8K3Y0
    • B2R9P7
    • Q4VBP0
    • Q96GE0
    • Q96TF2
    • Q9BWH1

    Protein attributes for SSTR2 Gene

    Size:
    369 amino acids
    Molecular mass:
    41333 Da
    Quaternary structure:
    • Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).

    Alternative splice isoforms for SSTR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSTR2 Gene

Proteomics data for SSTR2 Gene at MOPED

Post-translational modifications for SSTR2 Gene

  • Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSTR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR2 Gene

Domains for SSTR2 Gene

Gene Families for SSTR2 Gene

HGNC:
  • SSTR :GPCR / Class A : Somatostatin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

SSR2_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P30874
genes like me logo Genes that share domains with SSTR2: view

Function for SSTR2 Gene

Molecular function for SSTR2 Gene

GENATLAS Biochemistry: somatostatin receptor gene 2,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Gene Ontology (GO) - Molecular Function for SSTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004994 somatostatin receptor activity IEA --
GO:0005515 protein binding IPI 10551867
GO:0030165 PDZ domain binding IPI 10551867
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR2: view
genes like me logo Genes that share phenotypes with SSTR2: view

Animal Models for SSTR2 Gene

MGI Knock Outs for SSTR2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SSTR2 Gene

Localization for SSTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR2 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR2 Gene COMPARTMENTS Subcellular localization image for SSTR2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SSTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7914078
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SSTR2: view

Pathways for SSTR2 Gene

genes like me logo Genes that share pathways with SSTR2: view

Gene Ontology (GO) - Biological Process for SSTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006937 regulation of muscle contraction IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7914078
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with SSTR2: view

Compounds for SSTR2 Gene

(5) Tocris Compounds for SSTR2 Gene

Compound Action Cas Number
(1R,1S,3R/1R,1R,3S)-L-054,264 Potent and selective sst2 agonist [208706-12-1]
Cyclosomatostatin Non-selective sst receptor antagonist [84211-54-1]
CYN 154806 Selective sst2 antagonist [183658-72-2]
Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
Somatostatin Influences growth hormone release [51110-01-1]

(1) HMDB Compounds for SSTR2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for SSTR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Octreotide
  • Octreotida [Spanish]
83150-76-9 target binder
Pasireotide
396091-73-9 target
Vapreotide
  • BMY 41606
103222-11-3 target inducer

(67) IUPHAR Ligand for SSTR2 Gene

Ligand Type Action Affinity Pubmed IDs
L-054,522 Agonist Full agonist 11
BIM 23027 Agonist Agonist 10.85
EC 5-21 Agonist Full agonist 10.6
L-779,976 Agonist Full agonist 10.3
[125I]LTT-SRIF-28 Agonist Full agonist 10.3
[125I]Tyr10-CST14 Agonist Full agonist 10.1
NC 8-12 Agonist Full agonist 10
SRIF-14 Agonist Full agonist 10
SRIF-28 Agonist Full agonist 9.9
CST-17 Agonist Full agonist 9.9
CST-14 Agonist Full agonist 9.9
[125I]CGP 23996 Agonist Full agonist 9.8
[Ga-DOTA,Tyr3,Thr8]octreotide Agonist Full agonist 9.7
BIM 23052 Agonist Full agonist 9.7
DC 23-60 Agonist Full agonist 9.6
BASS antagonist Antagonist Antagonist 9.52
BIM 23059 Agonist Full agonist 9.4
[125I][Tyr3,Thr8]octreotide Agonist Full agonist 9.33
L-363,377 Agonist Full agonist 9.3
CGP 23996 Agonist Full agonist 9.3
BIM 23060 Agonist Full agonist 9.2
analog 31 Antagonist Antagonist 9.15
analog 3 Antagonist Antagonist 9.12
maltotriose-[125I][Tyr3,Thr8]octreotide Agonist Full agonist 9.02
[125I]Tyr3 SMS 201-995 Agonist Full agonist 8.89
Ga-NODAGA-LM3 Antagonist Antagonist 8.89
DOTA-BASS Antagonist Antagonist 8.82
KE 108 Agonist Full agonist 8.8
SOM-230 Agonist Full agonist 8.8
BIM 23068 Agonist Full agonist 8.8
In-NODAGATOC Agonist Full agonist 8.77
analog 30 Antagonist Antagonist 8.77
Ga-DOTA-NOC Agonist Full agonist 8.72
AM3 Agonist Full agonist 8.64
octreotide Agonist Full agonist 8.6
Ga-DOTA-TOC Agonist Full agonist 8.6
NODAGA-[Tyr3]-octreotide Agonist Full agonist 8.49
demotate 2 Agonist Full agonist 8.49
SiFA-Asn(AcNH-??-Glc)-PEG-Tyr??-octreotate Agonist Full agonist 8.48
[67Ga]NODAGA-[Tyr3]octreotide Agonist Full agonist 8.46
Ga-KE88 Agonist Full agonist 8.39
SiFA-Asn(AcNH-??-Glc)-Tyr??-octreotate Agonist Full agonist 8.36
L-362,855 Agonist Full agonist 8.3
[111In]DOTA-BOC-ATE Agonist Full agonist 8.3
BIM 23023 Agonist Full agonist 8.1
BIM 23034 Agonist Full agonist 8.1
[111In]DOTA-NOC Agonist Full agonist 8.1
lanreotide Agonist Full agonist 8
NC 4-28B Agonist Full agonist 8
Y-KE88 Agonist Full agonist 8
MK-678 Agonist Full agonist 7.9
vapreotide Agonist Full agonist 7.9
[111In]DOTA-NOC-ATE Agonist Full agonist 7.9
BIM 23030 Agonist Full agonist 7.8
BIM 23197 Agonist Full agonist 7.6
[111In,90Y]DOTA-NOC Agonist Full agonist 7.6
[111In,90Y]DOTA-OC Agonist Full agonist 7.6
BOC-ATE Agonist Full agonist 7.5
BIM 23627 Antagonist Antagonist 7.4
BIM 23454 Antagonist Antagonist 7.3
BIM 23056 Agonist Full agonist 7.2
L-363,301 Agonist Full agonist 7
[L-Tyr8]CYN 154806 Antagonist Antagonist 6.8
[D-Tyr8]CYN 154806 Antagonist Antagonist 6.7
NOC-ATE Agonist Full agonist 6.5
[111In,90Y]DOTA-LAN Agonist Full agonist 6.5
[111In,90Y]DOTA-TOC Agonist Full agonist 6.4

(28) Novoseek inferred chemical compound relationships for SSTR2 Gene

Compound -log(P) Hits PubMed IDs
octreotide 91.3 77
lanreotide 88.7 14
111in-pentetreotide 80.7 10
tyr-3-octreotide 75.7 2
vapreotide 67.9 1
genes like me logo Genes that share compounds with SSTR2: view

Transcripts for SSTR2 Gene

mRNA/cDNA for SSTR2 Gene

Unigene Clusters for SSTR2 Gene

Somatostatin receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for SSTR2 Gene

GeneLoc Exon Structure for
SSTR2
ECgene alternative splicing isoforms for
SSTR2

Expression for SSTR2 Gene

mRNA expression in normal human tissues for SSTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.9), Brain - Cerebellum (4.8), and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SSTR2 Gene

SOURCE GeneReport for Unigene cluster for SSTR2 Gene Hs.514451

mRNA Expression by UniProt/SwissProt for SSTR2 Gene

P30874-SSR2_HUMAN
Tissue specificity: Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
genes like me logo Genes that share expressions with SSTR2: view

Orthologs for SSTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR2 36
  • 99.64 (n)
  • 100 (a)
SSTR2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSTR2 36
  • 92.12 (n)
  • 94.84 (a)
SSTR2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSTR2 36
  • 93.04 (n)
  • 94.85 (a)
SSTR2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sstr2 36
  • 88.26 (n)
  • 93.77 (a)
Sstr2 16
Sstr2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSTR2 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSTR2 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr2 36
  • 87.99 (n)
  • 92.95 (a)
chicken
(Gallus gallus)
Aves SS2R 37
  • 88 (a)
OneToOne
SSTR2 36
  • 81.07 (n)
  • 88.32 (a)
lizard
(Anolis carolinensis)
Reptilia SSTR2 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19621 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr2 36
  • 73.53 (n)
  • 84.62 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333578 36
  • 66.67 (n)
  • 68.64 (a)
SSTR2 (1 of 2) 37
  • 63 (a)
OneToMany
SSTR2 (2 of 2) 37
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GPRALS3 36
  • 52.07 (n)
  • 41.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta star1 36
  • 53.86 (n)
  • 48.51 (a)
Drostar1 38
  • 39 (a)
AlCR2 38
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea npr-24 36
  • 45.56 (n)
  • 35.74 (a)
Species with no ortholog for SSTR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSTR2 Gene

ENSEMBL:
Gene Tree for SSTR2 (if available)
TreeFam:
Gene Tree for SSTR2 (if available)

Paralogs for SSTR2 Gene

genes like me logo Genes that share paralogs with SSTR2: view

Variants for SSTR2 Gene

Sequence variations from dbSNP and Humsavar for SSTR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs714925 -- 73,167,530(+) AGCCA(A/G)GTGAA intron-variant
rs728291 -- 73,167,649(+) AAACA(A/C)TTCTC intron-variant
rs895907 -- 73,164,158(+) tgtgt(A/G)tACCT upstream-variant-2KB
rs998571 -- 73,169,153(-) TCTGG(C/T)TTAGC intron-variant
rs1037261 -- 73,168,237(+) CGTGA(A/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSTR2 Gene

Variant ID Type Subtype PubMed ID
nsv833534 CNV Loss 17160897

Relevant External Links for SSTR2 Gene

HapMap Linkage Disequilibrium report
SSTR2
Human Gene Mutation Database (HGMD)
SSTR2

Disorders for SSTR2 Gene

(5) University of Copenhagen DISEASES for SSTR2 Gene

(49) Novoseek inferred disease relationships for SSTR2 Gene

Disease -log(P) Hits PubMed IDs
neuroendocrine tumors 73.5 11
pituitary adenoma 69.9 11
acromegaly 69.6 7
prolactinoma 65.3 5
insulinoma 60.9 6

Relevant External Links for SSTR2

Genetic Association Database (GAD)
SSTR2
Human Genome Epidemiology (HuGE) Navigator
SSTR2
genes like me logo Genes that share disorders with SSTR2: view

No data available for UniProtKB/Swiss-Prot for SSTR2 Gene

Publications for SSTR2 Gene

  1. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PMID: 1346068) Yamada Y. … Seino S. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  2. Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. (PMID: 8386508) Patel Y.C. … Srikant C.B. (Biochem. Biophys. Res. Commun. 1993) 3 4 23
  3. Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. (PMID: 15914528) Filopanti M. … Spada A. (J. Clin. Endocrinol. Metab. 2005) 3 23 49
  4. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PMID: 16214911) Canzian F. … Kaaks R. (Cancer Epidemiol. Biomarkers Prev. 2005) 3 23 49
  5. Polymorphisms in genes involved in GH1 release and their association with breast cancer risk. (PMID: 16606630) Wagner K. … FAPrsti A. (Carcinogenesis 2006) 3 23 49

Products for SSTR2 Gene

Sources for SSTR2 Gene

Back to Top

Content