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SSTR2 Gene

protein-coding GIFtS: 71

GC17P068672

somatostatin receptor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
SRIF-1 ^³
SS2R ^³

Descriptions
somatostatin receptor 2 ^²

External Ids
HGNC: 11331¹
Entrez Gene: 6752²
UniProtKB: P30874³
Ensembl: ENSG00000180616⁷

Search outside databases for aliases for SSTR2 gene

Previous GC identifers: GC17P071046 GC17P074201 GC17P071625 GC17P071758

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for SSTR2:

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory

proteins. The biologic effects of somatostatin are probably mediated by a family of G

protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the

superfamily of receptors having seven transmembrane segments and is expressed in highest levels in

cerebrum and kidney. [provided by RefSeq]

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874

Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin

sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine

phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F

cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels

Gene Wiki entry for SSTR2 (Somatostatin_receptor_2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SSTR2 gene

Entrez Gene cytogenetic band: 17q24 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q24

SSTR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P068672: (about GC identifiers)

Start:	68,672,755 bp from pter
End:	68,679,689 bp from pter
Size:	6,935 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874 (See protein sequence)

Recommended Name: Somatostatin receptor type 2

Size: 369 amino acids; 41333 Da

Subunit: The C-terminus interacts with SHANK1 PDZ domain

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A8K3Y0 Q4VBP0 Q96GE0 Q96TF2 Q9BWH1

Alternative splicing: 2 isoforms: P30874-1 P30874-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001041.1

ENSEMBL proteins:

ENSP00000326616 ENSP00000350198

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SSTR2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Somatostatin Receptor 2)
	Human Recombinant Proteins from Abnova (SSTR2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	TAS	7914078
GO:0005887	integral to plasma membrane	TAS	7914078

About this table

Antibodies for SSTR2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of SSTR2
	Sigma-Aldrich Antibodies for SSTR2
	R&D Systems Antibodies for SSTR2 (Somatostatin R2/SSTR2)
	Antibodies from Abcam (Somatostatin Receptor 2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SSTR2)
	Novus Biologicals Antibodies for SSTR2

Assays for SSTR2:

	Invitrogen Assays for SSTR2
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P30874

ProtoNet protein and cluster: P30874

2 Blocks protein families:

IPB000586 Somatostatin receptor signature

IPB002074 Somatostatin receptor type 2 signature

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SSTR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SSTR2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001050

Applied Biosystems Silencer® siRNAs for SSTR2

Sigma-Aldrich siRNA and siRNA Panels for SSTR2

Sigma-Aldrich shRNA Panels and shRNA for SSTR2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SSTR2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001050
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001050
untagged cDNA clone in CMV expression vector: NM_001050

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001050

UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874

Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin

sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine

phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F

cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels

Genatlas biochemistry entry for SSTR2:

somatostatin receptor gene 2,G protein coupled receptor superfamily

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Sstr2):

	behavior/neurological	digestive/alimentary	homeostasis/metabolism	nervous system
vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004994	somatostatin receptor activity	TAS	7914078
GO:0005515	protein binding	IPI	10551867
GO:0030165	PDZ domain binding	IPI	10551867

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for SSTR2 (Your Favorite Gene powered by Ingenuity)

Antiproliferative Role of Somatostatin Receptor 2

GeneDecks SSTR2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SSTR2

5/24 Interacting proteins for SSTR2 (ENSP00000350198³ P30874²) via UniProtKB, MINT, and/or STRING (see all 24 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PIK3R1	P27986²	MINT-2982013 MINT-2982090 MINT-2982067 MINT-2981982 MINT-2982036
SST	ENSP00000287641³	STRING (score=.999)
TCF4	ENSP00000346440³	STRING (score=.975)
SHANK1	ENSP00000293441³	STRING (score=.966)
PTPN6	ENSP00000326010³	STRING (score=.94)

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5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	TAS	7914078
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling	IEA	--
GO:0007218	neuropeptide signaling pathway	IEA	--
GO:0007267	cell-cell signaling	TAS	1346068

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for SSTR2:

Mixed Agonist/Antagonist Antagonist

Compounds for SSTR2 available from Tocris Bioscience

Compound	Action	CAS number
Octreotide	sst2, sst3 and sst5 agonist	[79517-01-4]
Somatostatin	Influences growth hormone release	[51110-01-1]
RC 160	Somatostatin analog	[103222-11-3]
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264	Potent and selective sst2 agonist	[208706-12-1]

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10/13 Novoseek chemical compound relationships for SSTR2 gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
111in-pentetreotide	80.68	15	16470879 (4), 16625862 (1), 19245777 (1), 19307732 (1) (see all 6)
tyr-3-octreotide	72.93	2	11585290 (1), 11965608 (1)
ribonucleic acid	43.65	7	7775631 (1), 10487698 (1), 10486467 (1), 10902809 (1) (see all 5)
thymidine	41.25	8	16954557 (1), 12011224 (1), 12353250 (1), 18509006 (1) (see all 8)
sodium iodide	29.73	1	12353250 (1)
forskolin	26.64	2	8386508 (1), 7914078 (1)
acth	20.13	3	7763254 (1), 17984930 (1)
glyceraldehyde 3-phosphate	19.07	4	10690891 (1), 11231991 (1), 16711510 (1)
phosphotyrosine	13.48	3	19365586 (1), 11914546 (1)
tyrosine	12.46	9	7907795 (3), 9419818 (1), 9212054 (1), 7674817 (1) (see all 6)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SSTR2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SSTR2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001050

Sigma-Aldrich siRNA and siRNA Panels for SSTR2

Sigma-Aldrich shRNA Panels and shRNA for SSTR2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001050

REFSEQ mRNAs for SSTR2 gene:

NM_001050.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001050

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001050
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001050
                                 untagged cDNA clone in CMV expression vector: NM_001050

Additional cDNA sequence:

AK290745.1 AK313866.1 BC000256.1 BC009522.1 BC019610.1 BC095495.1 BT019926.1 CR593522.1

2 DOTS entries:

DT.70101256 DT.120979121

24/66 AceView cDNA sequences (see all 66 ):

AI582640 AA599080 AW772094 AW405802 CB177996 BE326815 NM_001050 BC019610

BC000256 CF147826 BE252309 BQ416716 CR593522 BX090595 BG706556 BE782762

AK093950 BG329444 AW263315 AW452036 BM450923 BX419487 BC009522 AW772489

highest scoring ESTs for SSTR2:

AA932464 AI582640 AL536711 AW148723 AW263315 AW405802 AW772094 AW772489 BC000256 BC009522

Unigene Cluster for SSTR2:

Somatostatin receptor 2

Hs.514451 [show with all ESTs]

Unigene Representative Sequence: NM_001050

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SSTR2

ExUns:	1a	·	1b	^	2	^	3a	·	3b
SP1:
SP2:					-

About this scheme

ECgene alternative splicing isoforms for SSTR2

2 Ensembl transcripts including schematic representations:

ENST00000315332 ENST00000357585

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SSTR2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SSTR2

¹ / ² / ³

8 probe-sets matching SSTR2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40919_at²^{, 3}	U95-A	1	1.00	1.00	0.85	1.15	M81830	0.20	1.00	0.72	1
54346_at²^{, 3}	U95-B	1	0.88	1.00	0.77	0.85	AI972533	0.60	1.00	0.82	1
217455_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
214597_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000256	0.80	1.00	0.91	1
239031_at²^{, 3}	U133-B	1	0.91	1.00	--	--	BE618532	0.40	1.00	0.76	1
217455_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214597_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
239031_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.514451
Expression variation in blood from EXPOLDB for SSTR2
UniProtKB/Swiss-Prot: SSR2_HUMAN, P30874
Tissue specificity: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SSTR2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SSTR2¹	--	somatostatin receptor 2	93.5(n) 95.93(a)	403472 XM_847409.1 XP_852502.1
chimpanzee (Pan troglodytes)	SSTR2¹	--	somatostatin receptor 2	99.64(n) 100(a)	454854 XM_001167728.1 XP_001167728.1
cow (Bos taurus)	SSTR2¹	--	somatostatin receptor 2	92.12(n) 94.84(a)	282083 NM_174467.1 NP_776892.1
rat (Rattus norvegicus)	Sstr2¹	--	somatostatin receptor 2	87.99(n) 92.95(a)	54305 NM_019348.1 NP_062221.1
mouse (Mus musculus)	Sstr2^{1, 5}	11 (69.00 cM)⁵	somatostatin receptor 2^{1, 5}	88.35(n)¹ 93.77(a)¹	20606¹ NM_001042606.1¹ NP_001036071.1¹ AF008914⁵ AJ005518⁵ (see all 13)

About this table Species with no ortholog for SSTR2

ENSEMBL Gene Tree for SSTR2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SSTR2 gene

SSTR3² SSTR5² SSTR1² SSTR4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/80 NCBI SNPs in SSTR2 are shown (see all 80 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7210080^1,2	A,C,F,H	68678697(+)	`tctctT/Cgcacg`	1	--	ut3¹ ese³		9		EU EA WA NA CSAM	800
--	rs7220818^1,2	A,C,F,H	68678296(+)	`GTCCAA/GTTCAG`	1	--	ut3¹		9		EU EA WA NA CSAM	792
	rs11077670^1,2	A,C,F,H	68671381(+)	`CTGACG/AGTGAG`	1	--	ng5¹		13		EU EA WA NA CSAM	1206
--	rs6501602^1,2	A,C,F	68672032(+)	`GCCTGT/CTCCCC`	1	--	ng5¹		8		NA EU CSAM EA	514
--	rs7224362^1,2	A,C,F	68679136(+)	`TGAAAA/GGCAAA`	1	--	ut3¹ ese³		9		NA EU CSAM EA	596
	rs12936744^1,2	C,F,H	68679350(+)	`GCTGGG/TCATTA`	1	--	ut3¹		9		EU EA WA NA CSAM	788
	rs2881097^1,2	A,C,F	68671414(-)	`GGTGGC/GTAGCT`	1	--	ng5¹		5		NA EU CSAM EA	380
--	rs11655730^1,2	A,C	68672725(+)	`CGAGGG/TGCCCG`	1	--	ng5¹		0	--	--	--	--
	rs4988465^1,2	C,H	68677133(+)	`GGTGTC/TAACCA`	1	S/L	mis¹ ese³		8		EU EA WA	808
--	rs7210093^1,2	C,F	68678728(+)	`gggacT/Ctgggc`	1	--	ut3¹		5		NA EU CSAM EA	380

About this table

HapMap Linkage Disequilibrium images for SSTR2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 182452

10/47 Novoseek disease relationships for SSTR2 gene (see all 47 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroendocrine tumors	71.45	11	10718213 (2), 16135387 (1), 19245777 (1), 10699810 (1) (see all 8)
pituitary adenoma	69.70	11	8866248 (4), 11264647 (1), 11399907 (1), 15472224 (1) (see all 7)
acromegaly	67.13	8	15914528 (2), 10207690 (1), 15077912 (1), 17941904 (1) (see all 5)
prolactinoma	63.08	6	16595604 (1), 9410919 (1), 8106629 (1), 16625843 (1) (see all 5)
carcinoid	61.70	15	9622077 (2), 12734860 (2), 8653698 (2), 8132773 (1) (see all 9)
thyroid carcinoma medullary	61.53	6	12734860 (2), 15077916 (1), 8012966 (1), 11344221 (1)
adenoma	60.01	52	11399907 (5), 14661732 (4), 9059557 (3), 8866248 (3) (see all 21)
tumors	59.49	172	10768564 (4), 7854974 (4), 8012966 (4), 16470879 (4) (see all 82)
glucagonoma	59.12	4	8132773 (1), 12021920 (1)
insulinoma	58.98	6	8132773 (1), 16479142 (1), 12021920 (1), 14602773 (1) (see all 5)

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Human Gene Mutation Database: SSTR2
Genetic Association Database: SSTR2
Human Genome Epidemiology Navigator: SSTR2 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/332 PubMed articles for SSTR2 gene (see all 332 ):

Analysis of somatostatin receptors 2 and 5 polymorphisms in patients with acromegaly. (PubMed id 15914528)^{1, 3, 6} Filopanti M....Spada A. (2005)
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PubMed id 1346068)^{1, 3, 4} Yamada Y.... Seino S. (1992)
Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PubMed id 8449518)^{1, 2, 3} Yamada Y....Bell G.I. (1993)
Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)^{1, 3, 6} Canzian F....Kaaks R. (2005)
Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. (PubMed id 8386508)^{1, 3, 4} Patel Y.C.... Srikant C.B. (1993)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. (PubMed id 10551867)^{3, 4} Zitzer H.... Kreienkamp H.-J. (1999)
Genomic structure and transcriptional regulation of the human somatostatin receptor type 2. (PubMed id 10619399)^{3, 4} Petersenn S.... Schulte H.M. (1999)
Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. (PubMed id 18653781)^{1, 3} Grant M....Kumar U. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6752	HGNC: 11331	AceView: SSTR2	Ensembl:ENSG00000180616	euGenes: HUgn6752
ECgene: SSTR2	H-InvDB: SSTR2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SSTR2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SSTR2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for SSTR2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SSTR2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SSTR2		Antibodies for SSTR2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SSTR2		Small molecules for SSTR2
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Antibodies for SSTR2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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SSTR2 Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for SSTR2

Summaries
for SSTR2

Genomic Location
for SSTR2

Proteins
for SSTR2

Protein Domains/
Families
for SSTR2

Gene Function
for SSTR2

Pathways & Interactions
for SSTR2

Drugs & Compounds
for SSTR2

Transcripts
for SSTR2

Expression
for SSTR2

Orthologs
for SSTR2

Paralogs
for SSTR2

SNPs/Variants
for SSTR2

Disorders & Mutations
for SSTR2

Medical News
for SSTR2

Publications
for SSTR2

Search for SSTR2

Genome Databases showing SSTR2

Other Databases showing SSTR2

Specialized Databases showing SSTR2

Licensable Technologies
for SSTR2

Services
for SSTR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SSTR2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor SSTR2

Summariesfor SSTR2

Genomic Locationfor SSTR2

Proteinsfor SSTR2

Protein Domains/Familiesfor SSTR2

Gene Functionfor SSTR2

Pathways & Interactionsfor SSTR2

Drugs & Compoundsfor SSTR2

Transcriptsfor SSTR2

Expression for SSTR2

Orthologsfor SSTR2

Paralogsfor SSTR2

SNPs/Variantsfor SSTR2

Disorders & Mutationsfor SSTR2

Medical Newsfor SSTR2

Publicationsfor SSTR2

Search for SSTR2

Genome Databases showing SSTR2

Other Databases showing SSTR2

Specialized Databases showing SSTR2

Licensable Technologiesfor SSTR2

Servicesfor SSTR2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SSTR2

Summaries
for SSTR2

Genomic Location
for SSTR2

Proteins
for SSTR2

Protein Domains/
Families
for SSTR2

Gene Function
for SSTR2

Pathways & Interactions
for SSTR2

Drugs & Compounds
for SSTR2

Transcripts
for SSTR2

Expression
for SSTR2

Orthologs
for SSTR2

Paralogs
for SSTR2

SNPs/Variants
for SSTR2

Disorders & Mutations
for SSTR2

Medical News
for SSTR2

Publications
for SSTR2

Licensable Technologies
for SSTR2

Services
for SSTR2