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SSTR1 Gene

protein-coding   GIFtS: 66
GCID: GC14P038677

Somatostatin Receptor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Somatostatin Receptor 11 2
SRIF-22 3
SS-1-R2 3
SS1-R2 3
SS1R2 3
Somatostatin Receptor Type 12

External Ids:    HGNC: 113301   Entrez Gene: 67512   Ensembl: ENSG000001398747   OMIM: 1824515   UniProtKB: P308723   

Export aliases for SSTR1 gene to outside databases

Previous GC identifers: GC14P036059 GC14P032534 GC14P036668 GC14P036667 GC14P037746 GC14P018792


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSTR1 Gene:
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell
proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory
proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are
mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner.
The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven
transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the
superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin
receptor has greater affinity for somatostatin-14 than -28. (provided by RefSeq, Jul 2012)

GeneCards Summary for SSTR1 Gene:
SSTR1 (somatostatin receptor 1) is a protein-coding gene. Diseases associated with SSTR1 include pseudotumor cerebri, and oncogenic osteomalacia. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is SSTR3.

UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872
Function: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled
via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates
phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins

summary for SSTR1 Gene:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR1 (Somatostatin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSTR1 gene promoter:
         STAT5B   Nkx2-5   POU3F2   GATA-1   C/EBPalpha   Roaz   Arnt   c-Ets-1   AREB6   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSTR1 promoter sequence
   Search Chromatin IP Primers for SSTR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13   Ensembl cytogenetic band:  14q21.1   HGNC cytogenetic band: 14q13

SSTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P038677:  view genomic region     (about GC identifiers)

Start:
38,677,204 bp from pter      End:
38,682,272 bp from pter
Size:
5,069 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872 (See protein sequence)
Recommended Name: Somatostatin receptor type 1  
Size: 391 amino acids; 42686 Da
Subunit: Interacts with SKB1

Explore the universe of human proteins at neXtProt for SSTR1: NX_P30872

Explore proteomics data for SSTR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn44, Asn48
  • Modification sites at PhosphoSitePlus

  • See SSTR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001040.1  
    ENSEMBL proteins: 
     ENSP00000267377  
    Reactome Protein details: P30872

    SSTR1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SSTR1

    SSTR1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SSTR1
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    SSTR1 Assay Products:

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    Cloud-Clone Corp. CLIAs for SSTR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SSTR: GPCR / Class A : Somatostatin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: sst1 receptor
    Somatostatin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001116 Somatstn_rcpt_1
     IPR000586 Somatstn_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30872

    ProtoNet protein and cluster: P30872

    2 Blocks protein domains:
    IPB000586 Somatostatin receptor signature
    IPB001116 Somatostatin receptor type 1 signature


    UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872
    Similarity: Belongs to the G-protein coupled receptor 1 family


    SSTR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSR1_HUMAN, P30872
    Function: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled
    via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates
    phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins

         Genatlas biochemistry entry for SSTR1:
    somatostatin receptor gene 1,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004994somatostatin receptor activity IDA1346068
    GO:0005515protein binding ----
         
    SSTR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SSTR1:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Sstr1):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system  vision/eye 

    SSTR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sstr1tm1Dric for SSTR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSTR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSTR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSTR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSTR1

    miRNA
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    Block miRNA regulation of human, mouse, rat SSTR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSTR1 (see all 25):
    hsa-miR-4251 hsa-miR-330-5p hsa-miR-24-1* hsa-miR-146a hsa-miR-3942-5p hsa-miR-488 hsa-miR-24-2* hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSSTR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SSTR1
    Predesigned siRNA for gene silencing in human, mouse, rat SSTR1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SSTR1 (NM_001049)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSTR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SSTR1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSR1_HUMAN, P30872: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS1346068
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    SSTR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSTR1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    Peptide ligand-binding receptors0.60
    Neuroactive ligand-receptor interaction0.36
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways
    5Neuroscience
    Neuroscience

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for SSTR1
        Ca, cAMP and Lipid Signaling
    Neuroscience

    3 BioSystems Pathways for SSTR1
        SIDS Susceptibility Pathways
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for SSTR1
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for SSTR1):
        Neuroactive ligand-receptor interaction


    SSTR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSTR1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SSTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSTR1 (P308723 ENSP000002673774) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    DLG2Q157003, ENSP000003652724I2D: score=1 STRING: ENSP00000365272
    PRMT5O147443, ENSP000003191694I2D: score=1 STRING: ENSP00000319169
    SSTP612783, ENSP000002876414I2D: score=1 STRING: ENSP00000287641
    SSTR5P353463, ENSP000002938974I2D: score=1 STRING: ENSP00000293897
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS1346068
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8405411
    GO:0007215glutamate receptor signaling pathway IEA--
    GO:0007218neuropeptide signaling pathway ----

    SSTR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SSTR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    CYN 154806Selective sst2 antagonist[183658-72-2]
    (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Potent and selective sst2 agonist[208706-12-1]

    2 DrugBank Compounds for SSTR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    OctreotideOctreotida [Spanish] (see all 3)83150-76-9target--15103227 16625841 16223973 16438887 16625842
    Pasireotide-- 396091-73-9target--17395978 11980628

    Selected IUPHAR Ligands for SSTR1 (sst1 receptor) (see all 27)    About this table
    LigandTypeActionAffinityPubmed IDs
    [125I]Tyr10-CST14
    AgonistFull agonist109650799 10598788
    [125I]LTT-SRIF-28
    AgonistFull agonist109650799 10598788
    [125I]CGP 23996
    AgonistFull agonist8.9 - 9.68100350 10598788
    CST-17
    AgonistFull agonist9.1 - 9.69650799 15333679 10598788
    SRIF-14
    AgonistFull agonist8.6 - 9.515333679 10598788 11520208 9724791 9784130 9650799 9600011 8769372 7988476
    SRIF-28
    AgonistFull agonist8.6 - 9.415333679 7988476 10598788 8769372 9650799 9600011
    CST-14
    AgonistFull agonist7.7 - 9.19650799 10598788
    Des-AA5-[D-Trp8]SRIF
    AgonistFull agonist8.9 - 9.115658864
    L-797,591
    AgonistFull agonist8.89784130
    CH 275
    AgonistFull agonist8.3 - 8.79600011

    Selected Novoseek inferred chemical compound relationships for SSTR1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 81.7 8 8566856 (2), 7628822 (1), 16625842 (1), 12721506 (1) (see all 6)
    lanreotide 81.5 8 15103227 (3), 7628822 (1), 15671091 (1), 16625841 (1)
    111in-pentetreotide 63.6 1 15801004 (1)
    ribonucleic acid 39.1 1 10902809 (1)
    paraffin 30.6 2 12181718 (1), 11527930 (1)
    guanosine 5'-o-(3-thiotriphosphate) 30.2 1 8145728 (1)
    adenylate 29.9 1 7907795 (1)
    phosphotyrosine 26.9 3 7854346 (2), 11088001 (1)
    tyrosine 18.1 10 7907795 (2), 9892010 (1), 18951121 (1), 8786539 (1) (see all 5)
    threonine 12.4 2 9892010 (1), 11088001 (1)



    SSTR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SSTR1 gene: 
    NM_001049.2  

    Unigene Cluster for SSTR1:

    Somatostatin receptor 1
    Hs.248160  [show with all ESTs]
    Unigene Representative Sequence: NM_001049
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000267377(uc001wul.1)
    miRNA
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    hsa-miR-4251 hsa-miR-330-5p hsa-miR-24-1* hsa-miR-146a hsa-miR-3942-5p hsa-miR-488 hsa-miR-24-2* hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidSSTR1 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SSTR1 (NM_001049)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSTR1
      QuantiTect SYBR Green Assays in human, mouse, rat SSTR1
      QuantiFast Probe-based Assays in human, mouse, rat SSTR1

    Additional mRNA sequence: 

    AK290868.1 BC035618.1 BX248780.1 

    1 DOTS entry:

    DT.205737 

    Selected AceView cDNA sequences (see all 48):

    BI789177 BF876598 BX280512 F13186 AA350521 BC035618 AA889113 BU070951 
    CK821227 BX248780 AW163607 BU071151 NM_001049 BU071007 BI962657 CK821228 
    BF878834 F11984 AW162959 BX342217 BU072963 BI753905 AL556152 BX372173 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSTR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATACAATG
    SSTR1 Expression
    About this image


    SSTR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
    SSTR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSTR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248160

    UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872
    Tissue specificity: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSTR1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SSTR1
    OriGene qSTAR qPCR primer pairs in human, mouse for SSTR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSTR1
    QuantiTect SYBR Green Assays in human, mouse, rat SSTR1
    QuantiFast Probe-based Assays in human, mouse, rat SSTR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SSTR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sstr11 , 5 somatostatin receptor 11, 5 89.26(n)1
    98.72(a)1
      12 (25.61 cM)5
    206051  NM_009216.31  NP_033242.11 
     582117725 
    chicken
    (Gallus gallus)
    Aves SSTR11 somatostatin receptor 1 83.66(n)
    90.7(a)
      771648  NM_001113167.1  NP_001106638.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sstr11 somatostatin receptor 1 69.38(n)
    80.81(a)
      100485629  XM_004917240.1  XP_004917297.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sstr1a1 somatostatin receptor 1a 74.49(n)
    80.87(a)
      568254  XM_691574.5  XP_696666.1 


    ENSEMBL Gene Tree for SSTR1 (if available)
    TreeFam Gene Tree for SSTR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSTR1 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  
    GALR22  SSTR52  MCHR22  GALR32  SSTR22  MCHR12  OPRM12  NPBWR22  
    Selected SIMAP similar genes for SSTR1 using alignment to 1 protein entry:     SSR1_HUMAN(see all similar genes):
    SSTR2    SSTR4    SSTR3    SSTR5    NPBWR1    NPBWR2
    OPRL1    OPRD1    OPRK1    OPRM1    CCR8    GPR24
    MCHR1    ACKR3    BLR1    CXCR5    MCHR2    CCR1

    SSTR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSTR1 (see all 169)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486066041,2
    C--38675290(+) TCATAC/TCCATT 1 -- us2k10--------
    rs1824479301,2
    --38675313(+) CTCTTC/TCCCCT 1 -- us2k10--------
    rs1445565341,2
    --38675323(+) TCTGCC/TCCCAG 1 -- us2k10--------
    rs1879167451,2
    --38675387(+) GTCATA/GTAAAT 1 -- us2k10--------
    rs1915090351,2
    --38675408(+) CACACA/GTGGCC 1 -- us2k10--------
    rs1825285561,2
    --38675459(+) GCTTCA/GTCTAC 1 -- us2k10--------
    rs1873620281,2
    --38675501(+) TTATGG/TTTGAA 1 -- us2k10--------
    rs1922673241,2
    --38675594(+) TATGAA/GTAGTG 1 -- us2k10--------
    rs770652731,2
    C,F--38675651(+) CAATTT/ATGAGG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1856367701,2
    --38675805(+) CATTCC/TCACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SSTR1 (38677204 - 38682272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SSTR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832773CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSTR1
    DNA2.0 Custom Variant and Variant Library Synthesis for SSTR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182451    OMIM disorders: --

    Selected diseases for SSTR1 (see all 46):    
    About MalaCards
    pseudotumor cerebri    oncogenic osteomalacia    somatostatin analog    prolactinoma
    osteomalacia    serotonin syndrome    gastrinoma    pancreatic endocrine tumors
    pituitary adenoma    non-functioning pituitary adenoma    functioning pituitary adenoma    intracranial hypertension
    neuroma    acoustic neuroma    acromegaly    pituitary tumors
    arachnoiditis    insulinoma    pertussis    pheochromocytoma

    1 disease from the University of Copenhagen DISEASES database for SSTR1:
    Adenoma

    SSTR1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SSTR1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma nonfunctioning 71 2 15472224 (1)
    prolactinoma 64.9 6 10487698 (2), 18426817 (2), 8106629 (1), 16625843 (1)
    pituitary adenoma 64.4 7 12788890 (2), 8866248 (1), 17473207 (1), 12721506 (1) (see all 5)
    pituitary tumors 61.2 9 15103227 (4), 7530798 (1), 16379036 (1), 8106629 (1)
    carcinoid 56 3 8132773 (1), 16508627 (1), 8653698 (1)
    insulinoma 53.9 5 8132773 (1), 12181718 (1), 11772967 (1), 10866997 (1)
    thyroid carcinoma medullary 52.6 4 15077916 (1), 11344221 (1), 12359227 (1)
    acromegaly 49.4 1 15103227 (1)
    adenoma 45.2 11 12788890 (2), 17420609 (2), 10690891 (1), 12721506 (1) (see all 5)
    tumors 44.3 52 18823376 (3), 7530798 (2), 8012966 (2), 8515684 (2) (see all 29)

    Genetic Association Database (GAD): SSTR1
    Human Genome Epidemiology (HuGE) Navigator: SSTR1 (8 documents)

    Export disorders for SSTR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSTR1 gene, integrated from 10 sources (see all 182):
    (articles sorted by number of sources associating them with SSTR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PubMed id 1346068)1, 2, 9 Yamada Y.... Seino S. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. (PubMed id 10734105)1, 2, 9 Schwaerzler A.... Richter D. (J. Biol. Chem. 2000)
    3. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PubMed id 8449518)1, 3, 9 Yamada Y....Bell G.I. (Genomics 1993)
    4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    6. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    7. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    8. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)
    9. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. (PubMed id 19423539)1, 4 Johansson M....Kaaks R. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6751 HGNC: 11330 AceView: SSTR1 Ensembl:ENSG00000139874 euGenes: HUgn6751
    ECgene: SSTR1 Kegg: 6751 H-InvDB: SSTR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSTR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSTR1 gene:
    Search GeneIP for patents involving SSTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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