Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSTR1 Gene

Aliases for SSTR1 Gene

  • Somatostatin Receptor 1 2 3 5
  • SRIF-2 3 4
  • SS-1-R 3 4
  • SS1-R 3 4
  • SS1R 3 4
  • Somatostatin Receptor Type 1 3

External Ids for SSTR1 Gene

Previous GeneCards Identifiers for SSTR1 Gene

  • GC14P036059
  • GC14P032534
  • GC14P036668
  • GC14P036667
  • GC14P037746
  • GC14P038677
  • GC14P018792

Summaries for SSTR1 Gene

Entrez Gene Summary for SSTR1 Gene

  • Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

GeneCards Summary for SSTR1 Gene

SSTR1 (Somatostatin Receptor 1) is a Protein Coding gene. Diseases associated with SSTR1 include Acromegaly and Pituitary Adenoma, Prolactin-Secreting. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is SSTR4.

UniProtKB/Swiss-Prot for SSTR1 Gene

  • Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Tocris Summary for SSTR1 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR1 Gene

Genomics for SSTR1 Gene

Regulatory Elements for SSTR1 Gene

Enhancers for SSTR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F038289 0.8 ENCODE 11.1 +83.1 83112 2.6 JUN MAX RAD21 ZBTB40 RFX5 RCOR1 FOS MAFK TCF7L2 NFE2L2 CLEC14A SSTR1 ENSG00000259072 PIR41157
GH14F038042 0.9 Ensembl ENCODE 11 -165.5 -165456 0.5 TBP JUN RAD21 EP300 JUND SMC3 FOS TCF7L2 SSTR1 LOC105370456 ENSG00000258649
GH14F038253 0.2 ENCODE 10.7 +47.9 47917 4.4 CTCF PKNOX1 JUN RAD21 POLR2A FOS MAFK EZH2 CBX2 CEBPB CLEC14A SSTR1 GC14M038256 PIR37390
GH14F038250 0.5 Ensembl 10.4 +43.0 42985 0.7 POLR2A SMARCA4 SSTR1 GC14M038256 PIR37390 GC14M038195
GH14F037994 0.5 ENCODE 10.2 -212.8 -212812 1.2 SSTR1 ENSG00000258696 LINC00517
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SSTR1 on UCSC Golden Path with GeneCards custom track

Promoters for SSTR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001788727 901 2201 TBP ZNF48 RAD21 YY1 SMARCC2 ZNF202 ZNF263 PAF1 SMARCC1 USF2

Genomic Location for SSTR1 Gene

Chromosome:
14
Start:
38,207,999 bp from pter
End:
38,213,067 bp from pter
Size:
5,069 bases
Orientation:
Plus strand

Genomic View for SSTR1 Gene

Genes around SSTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR1 Gene

Proteins for SSTR1 Gene

  • Protein details for SSTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30872-SSR1_HUMAN
    Recommended name:
    Somatostatin receptor type 1
    Protein Accession:
    P30872

    Protein attributes for SSTR1 Gene

    Size:
    391 amino acids
    Molecular mass:
    42686 Da
    Quaternary structure:
    • Interacts with SKB1.

neXtProt entry for SSTR1 Gene

Post-translational modifications for SSTR1 Gene

  • Glycosylation at Asn 4, Asn 44, and Asn 48
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SSTR1 (SSTR1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for SSTR1

No data available for DME Specific Peptides for SSTR1 Gene

Domains & Families for SSTR1 Gene

Gene Families for SSTR1 Gene

Suggested Antigen Peptide Sequences for SSTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30872

UniProtKB/Swiss-Prot:

SSR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR1: view

Function for SSTR1 Gene

Molecular function for SSTR1 Gene

GENATLAS Biochemistry:
somatostatin receptor gene 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Gene Ontology (GO) - Molecular Function for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004994 somatostatin receptor activity IDA,TAS 1346068
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR1: view
genes like me logo Genes that share phenotypes with SSTR1: view

Animal Models for SSTR1 Gene

MGI Knock Outs for SSTR1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSTR1
  • R&D Systems cDNA Clones for SSTR1 (Somatostatin R1/SSTR1)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR1 Gene

Localization for SSTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR1 Gene COMPARTMENTS Subcellular localization image for SSTR1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1346068
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSTR1: view

Pathways & Interactions for SSTR1 Gene

genes like me logo Genes that share pathways with SSTR1: view

Gene Ontology (GO) - Biological Process for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 1346068
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007215 glutamate receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with SSTR1: view

No data available for SIGNOR curated interactions for SSTR1 Gene

Drugs & Compounds for SSTR1 Gene

(49) Drugs for SSTR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Octreotide Approved, Investigational Pharma Full agonist, Agonist, binder, Target sst2, sst3 and sst5 agonist 213
Pasireotide Approved Pharma inhibitor, agonist, Target 0
lanreotide Approved Pharma Full agonist, Agonist 82
Somatostatin Approved Pharma Influences growth hormone release 229
BIM 23052 Pharma Full agonist, Agonist sst5 receptor agonist 0

(8) Additional Compounds for SSTR1 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CST-14
Full agonist, Agonist
SOM-230
Full agonist, Agonist

(5) Tocris Compounds for SSTR1 Gene

Compound Action Cas Number
Cyclosomatostatin Non-selective sst receptor antagonist 84211-54-1
CYN 154806 Selective sst2 antagonist 183658-72-2
L-803,087 trifluoroacetate Potent and selective sst4 agonist 217480-26-7
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Somatostatin Influences growth hormone release 51110-01-1

(14) ApexBio Compounds for SSTR1 Gene

Compound Action Cas Number
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 208706-12-1
BIM 23052 sst5 receptor agonist 133073-82-2
BIM 23056 Somatostatin receptor ligand 150155-61-6
CH 275 174688-78-9
Cortistatin 14 193829-96-8
Cyclosomatostatin somatostatin receptor antagonist 84211-54-1
CYN 154806 183658-72-2
L-803,087 trifluoroacetate 217480-26-7
L-817,818 217480-27-8
Octreotide acetate octapeptide congener of native somatostatin 83150-76-9
Pasireotide 396091-73-9
Seglitide 81377-02-8
Somatostatin 1-28 74315-46-1
TT 232 147159-51-1
genes like me logo Genes that share compounds with SSTR1: view

Transcripts for SSTR1 Gene

mRNA/cDNA for SSTR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSTR1 Gene

Somatostatin receptor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSTR1
  • R&D Systems cDNA Clones for SSTR1 (Somatostatin R1/SSTR1)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR1 Gene

No ASD Table

Relevant External Links for SSTR1 Gene

GeneLoc Exon Structure for
SSTR1
ECgene alternative splicing isoforms for
SSTR1

Expression for SSTR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSTR1 Gene

mRNA differential expression in normal tissues according to GTEx for SSTR1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1), Brain - Hypothalamus (x4.9), Stomach (x4.5), and Brain - Frontal Cortex (BA9) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of SSTR1 Gene:

SSTR1

SOURCE GeneReport for Unigene cluster for SSTR1 Gene:

Hs.248160

mRNA Expression by UniProt/SwissProt for SSTR1 Gene:

P30872-SSR1_HUMAN
Tissue specificity: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
genes like me logo Genes that share expression patterns with SSTR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SSTR1 Gene

Orthologs for SSTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR1 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia SSTR1 34 35
  • 92.65 (n)
dog
(Canis familiaris)
Mammalia SSTR1 34 35
  • 92.22 (n)
oppossum
(Monodelphis domestica)
Mammalia SSTR1 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr1 34
  • 89.68 (n)
mouse
(Mus musculus)
Mammalia Sstr1 34 16 35
  • 89.26 (n)
chicken
(Gallus gallus)
Aves SS1R 35
  • 85 (a)
OneToOne
SSTR1 34
  • 83.66 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr1 34
  • 69.38 (n)
zebrafish
(Danio rerio)
Actinopterygii sstr1a 34 35
  • 74.49 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6499 34
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 36
  • 39 (a)
Drostar1 36
  • 37 (a)
Species where no ortholog for SSTR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR1 Gene

ENSEMBL:
Gene Tree for SSTR1 (if available)
TreeFam:
Gene Tree for SSTR1 (if available)

Paralogs for SSTR1 Gene

genes like me logo Genes that share paralogs with SSTR1: view

Variants for SSTR1 Gene

Sequence variations from dbSNP and Humsavar for SSTR1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10130808 -- 38,209,797(+) AGCGT(A/G)GACGC reference, synonymous-codon
rs10147411 -- 38,211,575(+) TCCCT(C/T)ACCCA utr-variant-3-prime
rs111852520 -- 38,213,344(+) ATGCA(C/T)TCAGT downstream-variant-500B
rs113049695 -- 38,208,625(+) CCCGG(A/G)ACTTC intron-variant
rs1135473 -- 38,211,908(+) GGGCG(A/G)GCATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SSTR1 Gene

Variant ID Type Subtype PubMed ID
esv3584282 CNV gain 25503493
nsv832773 CNV loss 17160897
nsv952830 CNV deletion 24416366

Variation tolerance for SSTR1 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSTR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSTR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSTR1 Gene

Disorders for SSTR1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SSTR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acromegaly
  • somatotroph adenoma
pituitary adenoma, prolactin-secreting
  • prolactinoma
medullary thyroid carcinoma, familial
  • medullary thyroid carcinoma
oncogenic osteomalacia
  • oo
serotonin syndrome
  • serotonergic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SSTR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSTR1

Genetic Association Database (GAD)
SSTR1
Human Genome Epidemiology (HuGE) Navigator
SSTR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSTR1
genes like me logo Genes that share disorders with SSTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSTR1 Gene

Publications for SSTR1 Gene

  1. Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. (PMID: 10734105) Schwaerzler A. … Richter D. (J. Biol. Chem. 2000) 3 4 22 64
  2. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PMID: 8449518) Yamada Y. … Bell G.I. (Genomics 1993) 2 3 22 64
  3. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PMID: 1346068) Yamada Y. … Seino S. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 22 64
  4. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  5. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PMID: 20634197) Canzian F. … Feigelson H.S. (Hum. Mol. Genet. 2010) 3 46 64

Products for SSTR1 Gene

Sources for SSTR1 Gene

Content
Loading form....