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Aliases for SSTR1 Gene

Aliases for SSTR1 Gene

  • Somatostatin Receptor 1 2 3
  • SRIF-2 3 4
  • SS-1-R 3 4
  • SS1-R 3 4
  • SS1R 3 4
  • Somatostatin Receptor Type 1 3

External Ids for SSTR1 Gene

Summaries for SSTR1 Gene

Entrez Gene Summary for SSTR1 Gene

  • Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

GeneCards Summary for SSTR1 Gene

SSTR1 (Somatostatin Receptor 1) is a Protein Coding gene. Diseases associated with SSTR1 include prostate cancer and pseudotumor cerebri. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include somatostatin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for SSTR1 Gene

  • Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins

Tocris Summary for SSTR1 Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the voltage sensor and is activated by changes in membrane potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR1 Gene

Genomics for SSTR1 Gene

Genomic Location for SSTR1 Gene

Start:
38,207,999 bp from pter
End:
38,213,067 bp from pter
Size:
5,069 bases
Orientation:
Plus strand

Genomic View for SSTR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR1 Gene

Regulatory Elements for SSTR1 Gene

Proteins for SSTR1 Gene

  • Protein details for SSTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30872-SSR1_HUMAN
    Recommended name:
    Somatostatin receptor type 1
    Protein Accession:
    P30872
    Secondary Accessions:

    Protein attributes for SSTR1 Gene

    Size:
    391 amino acids
    Molecular mass:
    42686 Da
    Quaternary structure:
    • Interacts with SKB1.

neXtProt entry for SSTR1 Gene

Proteomics data for SSTR1 Gene at MOPED

Post-translational modifications for SSTR1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn4, Asn44, and Asn48

Other Protein References for SSTR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SSTR1 Gene

Domains for SSTR1 Gene

Gene Families for SSTR1 Gene

HGNC:
  • SSTR :GPCR / Class A : Somatostatin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

SSR1_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P30872
genes like me logo Genes that share domains with SSTR1: view

Function for SSTR1 Gene

Molecular function for SSTR1 Gene

GENATLAS Biochemistry: somatostatin receptor gene 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins

Gene Ontology (GO) - Molecular Function for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004994 somatostatin receptor activity IDA 1346068
GO:0005515 protein binding --
GO:0042923 neuropeptide binding IBA --
genes like me logo Genes that share ontologies with SSTR1: view
genes like me logo Genes that share phenotypes with SSTR1: view

Animal Models for SSTR1 Gene

MGI Knock Outs for SSTR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SSTR1 Gene

Localization for SSTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR1 Gene COMPARTMENTS Subcellular localization image for SSTR1 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Gene Ontology (GO) - Cellular Components for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1346068
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SSTR1: view

Pathways for SSTR1 Gene

genes like me logo Genes that share pathways with SSTR1: view

Pathways by source for SSTR1 Gene

Gene Ontology (GO) - Biological Process for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 1346068
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411
GO:0007215 glutamate receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IBA --
genes like me logo Genes that share ontologies with SSTR1: view

Compounds for SSTR1 Gene

(5) Tocris Compounds for SSTR1 Gene

Compound Action Cas Number
(1R,1S,3R/1R,1R,3S)-L-054,264 Potent and selective sst2 agonist [208706-12-1]
Cyclosomatostatin Non-selective sst receptor antagonist [84211-54-1]
CYN 154806 Selective sst2 antagonist [183658-72-2]
Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
Somatostatin Influences growth hormone release [51110-01-1]

(2) Drugbank Compounds for SSTR1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Octreotide
  • Octreotida [Spanish]
83150-76-9 target
Pasireotide
396091-73-9 target

(27) IUPHAR Ligand for SSTR1 Gene

Ligand Type Action Affinity Pubmed IDs
[125I]LTT-SRIF-28 Agonist Full agonist 10.3
[125I]Tyr10-CST14 Agonist Full agonist 10.1
SRIF-14 Agonist Full agonist 10
CST-17 Agonist Full agonist 9.9
SRIF-28 Agonist Full agonist 9.9
CST-14 Agonist Full agonist 9.9
[125I]CGP 23996 Agonist Full agonist 9.8
BIM 23052 Agonist Full agonist 9.7
CGP 23996 Agonist Full agonist 9.3
L-797,591 Agonist Full agonist 8.8
KE 108 Agonist Full agonist 8.8
SOM-230 Agonist Full agonist 8.8
CH 275 Agonist Full agonist 8.7
Des-AA5-[D-Trp8]SRIF Agonist Full agonist 8.5
L-817,818 Agonist Full agonist 8.5
Des-AA1,2,5,12,13-[D-Trp8]SRIF Agonist Full agonist 8.3
L-362,855 Agonist Full agonist 8.3
cyclo(7-12) Des-AA1,2,5-[Glu7,D-Trp8,IAmp9,m-I-Tyr11,hhLys12]SRIF Agonist Full agonist 8.2
SRA880 Antagonist Antagonist 8.1
NC 4-28B Agonist Full agonist 8
Des-AA1,5-[Tyr2,D-Trp8,IAmp9]SRIF Agonist Full agonist 7.8
BIM 23050 Agonist Full agonist 7.8
Des-Ala1,2,5-[D-Trp8,IAmp9]SRIF Agonist Full agonist 7.5
BIM 23627 Antagonist Antagonist 7.4
BIM 23454 Antagonist Antagonist 7.3
[L-Tyr8]CYN 154806 Antagonist Antagonist 6.8
[D-Tyr8]CYN 154806 Antagonist Antagonist 6.7

(15) Novoseek inferred chemical compound relationships for SSTR1 Gene

Compound -log(P) Hits PubMed IDs
octreotide 81.7 7
lanreotide 81.5 6
111in-pentetreotide 63.6 1
ribonucleic acid 39.1 1
paraffin 30.6 2
genes like me logo Genes that share compounds with SSTR1: view

Transcripts for SSTR1 Gene

mRNA/cDNA for SSTR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSTR1 Gene

Somatostatin receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR1 Gene

No ASD Table

Relevant External Links for SSTR1 Gene

GeneLoc Exon Structure for
SSTR1
ECgene alternative splicing isoforms for
SSTR1

Expression for SSTR1 Gene

mRNA expression in normal human tissues for SSTR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSTR1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (5.1), Brain - Hypothalamus (4.9), Stomach (4.5), and Brain - Frontal Cortex (BA9) (4.0).

SOURCE GeneReport for Unigene cluster for SSTR1 Gene Hs.248160

mRNA Expression by UniProt/SwissProt for SSTR1 Gene

P30872-SSR1_HUMAN
Tissue specificity: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach
genes like me logo Genes that share expressions with SSTR1: view

Orthologs for SSTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSTR1 36
  • 99.57 (n)
  • 100 (a)
SSTR1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSTR1 36
  • 92.65 (n)
  • 98.72 (a)
SSTR1 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSTR1 36
  • 92.22 (n)
  • 98.72 (a)
SSTR1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sstr1 36
  • 89.26 (n)
  • 98.72 (a)
Sstr1 16
Sstr1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSTR1 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr1 36
  • 89.68 (n)
  • 97.44 (a)
chicken
(Gallus gallus)
Aves SS1R 37
  • 85 (a)
OneToOne
SSTR1 36
  • 83.66 (n)
  • 90.7 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr1 36
  • 69.38 (n)
  • 80.81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6499 36
zebrafish
(Danio rerio)
Actinopterygii sstr1a 36
  • 74.49 (n)
  • 80.87 (a)
sstr1a 37
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Drostar1 38
  • 37 (a)
AlCR2 38
  • 39 (a)
Species with no ortholog for SSTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR1 Gene

ENSEMBL:
Gene Tree for SSTR1 (if available)
TreeFam:
Gene Tree for SSTR1 (if available)

Paralogs for SSTR1 Gene

genes like me logo Genes that share paralogs with SSTR1: view

Variants for SSTR1 Gene

Sequence variations from dbSNP and Humsavar for SSTR1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1135473 -- 38,211,908(+) GGGCG(A/G)GCATG utr-variant-3-prime
rs1135474 -- 38,212,021(+) TTTTT(C/G)ATTGT utr-variant-3-prime
rs2228497 -- 38,210,268(+) CTGGT(C/T)AACGT reference, synonymous-codon
rs2803939 -- 38,206,688(-) AATGC(C/T)TTTTA upstream-variant-2KB
rs4073844 -- 38,208,330(+) TTTGC(A/G)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSTR1 Gene

Variant ID Type Subtype PubMed ID
nsv832773 CNV Loss 17160897

Relevant External Links for SSTR1 Gene

HapMap Linkage Disequilibrium report
SSTR1

Disorders for SSTR1 Gene

(1) University of Copenhagen DISEASES for SSTR1 Gene

(24) Novoseek inferred disease relationships for SSTR1 Gene

Disease -log(P) Hits PubMed IDs
pituitary adenoma nonfunctioning 71 1
prolactinoma 64.9 6
pituitary adenoma 64.4 6
pituitary tumors 61.2 7
carcinoid 56 3

Relevant External Links for SSTR1

Genetic Association Database (GAD)
SSTR1
Human Genome Epidemiology (HuGE) Navigator
SSTR1
genes like me logo Genes that share disorders with SSTR1: view

No data available for UniProtKB/Swiss-Prot for SSTR1 Gene

Publications for SSTR1 Gene

  1. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PMID: 1346068) Yamada Y. … Seino S. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  2. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PMID: 8449518) Yamada Y. … Bell G.I. (Genomics 1993) 2 3 23
  3. Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. (PMID: 10734105) Schwaerzler A. … Richter D. (J. Biol. Chem. 2000) 3 4 23
  4. Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. (PMID: 9892225) Kumar U. … Patel Y.C. (Diabetes 1999) 3 23
  5. Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study. (PMID: 11527930) Klisovic D.D. … Lubow M. (Invest. Ophthalmol. Vis. Sci. 2001) 3 23

Products for SSTR1 Gene

Sources for SSTR1 Gene

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