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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSTR1 Gene

protein-coding   GIFtS: 66
GCID: GC14P038677

somatostatin receptor 1
 Explore 43 diseases affiliated with
SSTR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SSTR1    

Aliases
for SSTR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Somatostatin Receptor 11 2
SRIF-22 3
SS-1-R2 3
SS1-R2 3
SS1R2 3
Somatostatin Receptor Type 12

External Ids:    HGNC: 113301   Entrez Gene: 67512   Ensembl: ENSG000001398747   OMIM: 1824515   UniProtKB: P308723   

Export aliases for SSTR1 gene to outside databases

Previous GC identifers: GC14P036059 GC14P032534 GC14P036668 GC14P036667 GC14P037746 GC14P018792


Summaries
for SSTR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SSTR1:
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell
proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory
proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are
mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The
protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane
segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as
with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity
for somatostatin-14 than -28. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872
Function: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via
pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine
phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins

summary for SSTR1:
Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in
excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low
levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are
composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits.
alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.
The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane
potential. S4 is also involved in channel gating.

Gene Wiki entry for SSTR1 (Somatostatin receptor 1)


Genomic Views
for SSTR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSTR1 gene promoter:
         STAT5B   Nkx2-5   POU3F2   GATA-1   C/EBPalpha   Roaz   Arnt   c-Ets-1   AREB6   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSTR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSTR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSTR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13   Ensembl cytogenetic band:  14q21.1   HGNC cytogenetic band: 14q13

SSTR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSTR1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P038677:  view genomic region     (about GC identifiers)

Start:
 38,677,204 bp from pter      End:
 38,682,272 bp from pter
Size:
 5,069 bases      Orientation:
 plus strand

Proteins
for SSTR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872 (See protein sequence)
Recommended Name: Somatostatin receptor type 1  
Size: 391 amino acids; 42686 Da
Subunit: Interacts with SKB1
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for SSTR1: NX_P30872

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30872

    • SSTR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001040.1  
    ENSEMBL proteins: 
     ENSP00000267377  
    Reactome Protein details: P30872
    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SSTR1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS1346068


    SSTR1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SSTR1

    Protein Domains /
    Families
    for SSTR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SSTR1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001116 Somatstn_rcpt_1
     IPR000586 Somatstn_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30872

    ProtoNet protein and cluster: P30872

    2 Blocks protein families:
    IPB000586 Somatostatin receptor signature
    IPB001116 Somatostatin receptor type 1 signature


    UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Function
    for SSTR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872
    Function: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via
    pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine
    phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins

         Genatlas biochemistry entry for SSTR1:
    somatostatin receptor gene 1,G protein coupled receptor superfamily

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSTR1
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate SSTR1 (see all 25):
    hsa-miR-4251 hsa-miR-330-5p hsa-miR-24-1* hsa-miR-146a hsa-miR-3942-5p hsa-miR-488 hsa-miR-24-2* hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: SSTR1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSTR1 (see all 7)
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SSTR1 (NM_001049)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSTR1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SSTR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004994somatostatin receptor activity IDA1346068


    SSTR1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SSTR1:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Sstr1tm1Dric for SSTR1
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Sstr1):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system  vision/eye 

    SSTR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SSTR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		G alpha (i) signalling events0.44
    		GPCR ligand binding0.75
    		GPCRs, Class A Rhodopsin-like0.41
    		Peptide ligand-binding receptors0.61
    		Neuroactive ligand-receptor interaction0.38
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    		Peptide GPCRs0.46
    4Neuroscience
    		Neuroscience1.00
    5Ca, cAMP and Lipid Signaling
    		Ca, cAMP and Lipid Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SSTR1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    2 Cell Signaling Technology (CST) Pathways for SSTR1
        Ca, cAMP and Lipid Signaling
    Neuroscience

    3 BioSystems Pathways for SSTR1 
        SIDS Susceptibility Pathways
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/7        Reactome Pathways for SSTR1 (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for SSTR1):
        Neuroactive ligand-receptor interaction


    SSTR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSTR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/148 Interacting proteins for SSTR1 (P308723 ENSP000002673774) via UniProtKB, MINT, STRING, and/or I2D (see all 148)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CORTO002303, ENSP000003662484I2D: score=1 STRING: ENSP00000366248
    PRMT5O147443, ENSP000003191694I2D: score=1 STRING: ENSP00000319169
    SSTP612783, ENSP000002876414I2D: score=1 STRING: ENSP00000287641
    SSTR5P353463, ENSP000002938974I2D: score=1 STRING: ENSP00000293897
    DLG2Q157003I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS1346068
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS8405411
    GO:0007215glutamate receptor signaling pathway IEA--
    GO:0007218neuropeptide signaling pathway ----


    SSTR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SSTR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SSTR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SSTR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    RC 160Somatostatin analog[103222-11-3]
    CH 275Potent and selective sst1 receptor agonist[174688-78-9]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]

    1 DrugBank Compound for SSTR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    OctreotideOctreotida [Spanish] (see all 3)83150-76-9target--15103227 16625841 16223973 16438887 16625842

    10/15 Novoseek chemical compound relationships for SSTR1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 81.7 8 8566856 (2), 7628822 (1), 16625842 (1), 12721506 (1) (see all 6)
    lanreotide 81.5 8 15103227 (3), 7628822 (1), 15671091 (1), 16625841 (1)
    111in-pentetreotide 63.6 1 15801004 (1)
    ribonucleic acid 39.1 1 10902809 (1)
    paraffin 30.6 2 12181718 (1), 11527930 (1)
    guanosine 5'-o-(3-thiotriphosphate) 30.2 1 8145728 (1)
    adenylate 29.9 1 7907795 (1)
    phosphotyrosine 26.9 3 7854346 (2), 11088001 (1)
    tyrosine 18.1 10 7907795 (2), 9892010 (1), 18951121 (1), 8786539 (1) (see all 5)
    threonine 12.4 2 9892010 (1), 11088001 (1)

    Search CenterWatch for drugs/clinical trials and news about SSTR1 / SSR1 

    Transcripts
    for SSTR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SSTR1 gene: 
    NM_001049.2  

    Unigene Cluster for SSTR1:

    Somatostatin receptor 1
    Hs.248160  [show with all ESTs]
    Unigene Representative Sequence: NM_001049
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000267377(uc001wul.1)

    miRNA
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    hsa-miR-4251 hsa-miR-330-5p hsa-miR-24-1* hsa-miR-146a hsa-miR-3942-5p hsa-miR-488 hsa-miR-24-2* hsa-miR-149
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSTR1 (see all 7)
    OriGene shRNA RFP: SSTR1
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SSTR1 (NM_001049)
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    Primer
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    Additional cDNA sequence: 

    AK290868.1 BC035618.1 BX248780.1 

    1 DOTS entry:

    DT.205737 

    24/48 AceView cDNA sequences (see all 48):

    BU071007 CK821227 CK821228 BX280512 BX248780 F13186 BU071151 AA350521 
    BU070951 BF876598 BF878834 BI789177 BC035618 AA889113 BI962657 NM_001049 
    AW163607 AI129156 BI254898 BI753905 AW162959 F11984 BX342217 BX372173 

    GeneLoc Exon Structure


    Expression
    for SSTR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSTR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATACAATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SSTR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FollicleGranulosa CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium

    See SSTR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSTR1

    SOURCE GeneReport for Unigene cluster: Hs.248160

    UniProtKB/Swiss-Prot: SSR1_HUMAN, P30872
    Tissue specificity: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach

        SABiosciences Expression via Pathway-Focused PCR Arrays including SSTR1: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSTR1

    Orthologs
    for SSTR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SSTR1 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SSTR11 somatostatin receptor 1 81.41(n)
    86.12(a)    		   771648  NM_001113167.1  NP_001106638.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sstr1a1 somatostatin receptor 1a 74.63(n)
    82.09(a)    		   568254  XM_691574.4  XP_696666.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta AlCR23 G-protein coupled receptor protein signaling
    pathway more    		 39(a)
    (best of 2)    		   75D1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y54E2A.16
    		 --
    		 13(a)
    		 possible ortholog
    		 II(14734335-14739167)


    ENSEMBL Gene Tree for SSTR1 (if available)
    TreeFam Gene Tree for SSTR1 (if available) 

    Paralogs
    for SSTR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSTR1 gene
    SSTR32  OPRL12  OPRK12  NPBWR12  OPRD12  KISS1R2  GALR12  SSTR42  
    GALR22  SSTR52  MCHR22  GALR32  SSTR22  NPBWR22  OPRM12  MCHR12  
    18/42 SIMAP similar genes for SSTR1 using alignment to 1 protein entry:     SSR1_HUMAN(see all similar genes):
    SSTR2    SSTR4    SSTR3    SSTR5    NPBWR1    NPBWR2
    OPRL1    OPRK1    OPRD1    OPRM1    CCR8    GPR24
    MCHR1    BLR1    CXCR5    CXCR7    MCHR2    CCR1

    SSTR1 for paralogs           About GeneDecksing



    Genomic Variants
    for SSTR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/133 NCBI SNPs in SSTR1 are shown (see all 133)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1486066041,2
    		--38675290(+) TCATAC/TCCATT 1 -- us2k10--------
    rs1824479301,2
    		--38675313(+) CTCTTC/TCCCCT 1 -- us2k10--------
    rs1445565341,2
    		--38675323(+) TCTGCC/TCCCAG 1 -- us2k10--------
    rs1879167451,2
    		--38675387(+) GTCATA/GTAAAT 1 -- us2k10--------
    rs1915090351,2
    		--38675408(+) CACACA/GTGGCC 1 -- us2k10--------
    rs1825285561,2
    		--38675459(+) GCTTCA/GTCTAC 1 -- us2k10--------
    rs1873620281,2
    		--38675501(+) TTATGG/TTTGAA 1 -- us2k10--------
    rs1922673241,2
    		--38675594(+) TATGAA/GTAGTG 1 -- us2k10--------
    rs770652731,2
    		F,--38675651(+) CAATTT/ATGAGG 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1856367701,2
    		--38675805(+) CATTCC/TCACTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SSTR1 (38677204 - 38682272 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SSTR1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for SSTR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SSTR1 for disorders           About GeneDecksing

    OMIM gene information: 182451    OMIM disorders: --

    20/43 diseases for SSTR1 (see all 43):    About MalaCards
    pseudotumor cerebri    oncogenic osteomalacia    pituitary adenoma    acoustic neuroma
    functioning pituitary adenoma    osteomalacia    neuroma    prolactinoma
    pancreatic endocrine tumors    pituitary tumor    intracranial hypertension    acromegaly
    arachnoiditis    adenoma    insulinoma    carcinoid tumors
    neuroendocrine tumor    pheochromocytoma    graves' disease    keratoconus

    1 disease from the University of Copenhagen DISEASES database for SSTR1:
    Adenoma

    10/24 Novoseek disease relationships for SSTR1 gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pituitary adenoma nonfunctioning 71 2 15472224 (1)
    prolactinoma 64.9 6 10487698 (2), 18426817 (2), 8106629 (1), 16625843 (1)
    pituitary adenoma 64.4 7 12788890 (2), 8866248 (1), 17473207 (1), 12721506 (1) (see all 5)
    pituitary tumors 61.2 9 15103227 (4), 7530798 (1), 16379036 (1), 8106629 (1)
    carcinoid 56 3 8132773 (1), 16508627 (1), 8653698 (1)
    insulinoma 53.9 5 8132773 (1), 12181718 (1), 11772967 (1), 10866997 (1)
    thyroid carcinoma medullary 52.6 4 15077916 (1), 11344221 (1), 12359227 (1)
    acromegaly 49.4 1 15103227 (1)
    adenoma 45.2 11 12788890 (2), 17420609 (2), 10690891 (1), 12721506 (1) (see all 5)
    tumors 44.3 52 18823376 (3), 7530798 (2), 8012966 (2), 8515684 (2) (see all 29)

    Genetic Association Database (GAD): SSTR1
    Human Genome Epidemiology (HuGE) Navigator: SSTR1 (8 documents)

    Export disorders for SSTR1 gene to outside databases

    Publications
    for SSTR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSTR1 gene, integrated from 9 sources (see all 177):
    (articles sorted by number of sources associating them with SSTR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PubMed id 1346068)1, 2, 9 Yamada Y.... Seino S. (1992)
    2. Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. (PubMed id 10734105)1, 2, 9 Schwaerzler A.... Richter D. (2000)
    3. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PubMed id 8449518)1, 3, 9 Yamada Y....Bell G.I. (1993)
    4. Genetic variation in the growth hormone synthesis pathway in relation to circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3, and breast cancer risk: results from the European prospective investigation into cancer and nutrition study. (PubMed id 16214911)1, 4 Canzian F....Kaaks R. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer. (PubMed id 18823376)1, 9 Li M....Fisher W.E. (2008)
    7. Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs. (PubMed id 15103227)7, 9 Matrone C....Annunziato L. (2004)
    8. Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion. (PubMed id 12788890)1, 9 Zatelli M.C....degli Uberti E.C. (2003)
    9. Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. (PubMed id 9892225)1, 9 Kumar U....Patel Y.C. (1999)
    10. Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study. (PubMed id 11527930)1, 9 Klisovic D.D....Lubow M. (2001)

    External Searches for SSTR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing SSTR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6751 HGNC: 11330 AceView: SSTR1 Ensembl:ENSG00000139874 euGenes: HUgn6751
    ECgene: SSTR1 Kegg: 6751 H-InvDB: SSTR1

    Other Databases showing SSTR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SSTR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSTR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSTR1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SSTR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SSTR1 gene:
    Search GeneIP for patents involving SSTR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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