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Aliases for SSTR1 Gene

Aliases for SSTR1 Gene

  • Somatostatin Receptor 1 2 3 5
  • SRIF-2 3 4
  • SS-1-R 3 4
  • SS1-R 3 4
  • SS1R 3 4

External Ids for SSTR1 Gene

Previous GeneCards Identifiers for SSTR1 Gene

  • GC14P036059
  • GC14P032534
  • GC14P036668
  • GC14P036667
  • GC14P037746
  • GC14P038677
  • GC14P018792

Summaries for SSTR1 Gene

Entrez Gene Summary for SSTR1 Gene

  • Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

GeneCards Summary for SSTR1 Gene

SSTR1 (Somatostatin Receptor 1) is a Protein Coding gene. Diseases associated with SSTR1 include Acromegaly and Medullary Thyroid Carcinoma, Familial. Among its related pathways are Peptide ligand-binding receptors and cAMP signaling pathway. GO annotations related to this gene include G-protein coupled receptor activity and somatostatin receptor activity. An important paralog of this gene is GALR2.

UniProtKB/Swiss-Prot for SSTR1 Gene

  • Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Tocris Summary for SSTR1 Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SSTR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSTR1 Gene

Genomics for SSTR1 Gene

Regulatory Elements for SSTR1 Gene

Enhancers for SSTR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSTR1 on UCSC Golden Path with GeneCards custom track

Promoters for SSTR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSTR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSTR1 Gene

Chromosome:
14
Start:
38,207,999 bp from pter
End:
38,213,067 bp from pter
Size:
5,069 bases
Orientation:
Plus strand

Genomic View for SSTR1 Gene

Genes around SSTR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSTR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSTR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSTR1 Gene

Proteins for SSTR1 Gene

  • Protein details for SSTR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30872-SSR1_HUMAN
    Recommended name:
    Somatostatin receptor type 1
    Protein Accession:
    P30872

    Protein attributes for SSTR1 Gene

    Size:
    391 amino acids
    Molecular mass:
    42686 Da
    Quaternary structure:
    • Interacts with SKB1.

neXtProt entry for SSTR1 Gene

Proteomics data for SSTR1 Gene at MOPED

Post-translational modifications for SSTR1 Gene

  • Glycosylation at Asn 4, Asn 44, and Asn 48
  • Modification sites at PhosphoSitePlus

Other Protein References for SSTR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SSTR1 (SSTR1)

No data available for DME Specific Peptides for SSTR1 Gene

Domains & Families for SSTR1 Gene

Gene Families for SSTR1 Gene

Suggested Antigen Peptide Sequences for SSTR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30872

UniProtKB/Swiss-Prot:

SSR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with SSTR1: view

Function for SSTR1 Gene

Molecular function for SSTR1 Gene

GENATLAS Biochemistry:
somatostatin receptor gene 1,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
genes like me logo Genes that share phenotypes with SSTR1: view

Animal Models for SSTR1 Gene

MGI Knock Outs for SSTR1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSTR1 Gene

Localization for SSTR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSTR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSTR1 Gene COMPARTMENTS Subcellular localization image for SSTR1 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with SSTR1: view

Pathways & Interactions for SSTR1 Gene

genes like me logo Genes that share pathways with SSTR1: view

Gene Ontology (GO) - Biological Process for SSTR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007267 cell-cell signaling TAS 1346068
GO:0007584 response to nutrient TAS 1346068
GO:0007586 digestion TAS 1346068
GO:0008285 negative regulation of cell proliferation TAS 9886848
genes like me logo Genes that share ontologies with SSTR1: view

No data available for SIGNOR curated interactions for SSTR1 Gene

Drugs & Compounds for SSTR1 Gene

(39) Drugs for SSTR1 Gene - From: DrugBank, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Octreotide Approved, Investigational Pharma Full agonist, Agonist, binder, Target sst2, sst3 and sst5 agonist 205
Pasireotide Approved Pharma inhibitor, agonist, Target 0
[<sup>125</sup>I]CGP 23996 Pharma Full agonist, Agonist 0
[<sup>125</sup>I]LTT-SRIF-28 Pharma Full agonist, Agonist 0
[<sup>125</sup>I]Tyr<sup>10</sup>-CST14 Pharma Full agonist, Agonist 0

(11) Additional Compounds for SSTR1 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CST-14
Full agonist, Agonist
SOM-230
Full agonist, Agonist
L-803,087 trifluoroacetate
217480-26-7
Somatostatin 1-28
74315-46-1

(5) Tocris Compounds for SSTR1 Gene

Compound Action Cas Number
L-803,087 trifluoroacetate Potent and selective sst4 agonist 217480-26-7
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Seglitide sst2 and sst5 agonist 81377-02-8
Somatostatin Influences growth hormone release 51110-01-1
Somatostatin 1-28 sst receptor agonist 74315-46-1
genes like me logo Genes that share compounds with SSTR1: view

Transcripts for SSTR1 Gene

mRNA/cDNA for SSTR1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSTR1 Gene

Somatostatin receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSTR1 Gene

No ASD Table

Relevant External Links for SSTR1 Gene

GeneLoc Exon Structure for
SSTR1
ECgene alternative splicing isoforms for
SSTR1

Expression for SSTR1 Gene

mRNA expression in normal human tissues for SSTR1 Gene

mRNA differential expression in normal tissues according to GTEx for SSTR1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.1), Brain - Hypothalamus (x4.9), Stomach (x4.5), and Brain - Frontal Cortex (BA9) (x4.0).

SOURCE GeneReport for Unigene cluster for SSTR1 Gene Hs.248160

mRNA Expression by UniProt/SwissProt for SSTR1 Gene

P30872-SSR1_HUMAN
Tissue specificity: Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
genes like me logo Genes that share expression patterns with SSTR1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SSTR1 Gene

Orthologs for SSTR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSTR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSTR1 35
  • 92.65 (n)
  • 98.72 (a)
SSTR1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSTR1 35
  • 92.22 (n)
  • 98.72 (a)
SSTR1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sstr1 35
  • 89.26 (n)
  • 98.72 (a)
Sstr1 16
Sstr1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSTR1 35
  • 99.57 (n)
  • 100 (a)
SSTR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sstr1 35
  • 89.68 (n)
  • 97.44 (a)
oppossum
(Monodelphis domestica)
Mammalia SSTR1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSTR1 35
  • 83.66 (n)
  • 90.7 (a)
SS1R 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sstr1 35
  • 69.38 (n)
  • 80.81 (a)
zebrafish
(Danio rerio)
Actinopterygii sstr1a 35
  • 74.49 (n)
  • 80.87 (a)
sstr1a 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6499 35
fruit fly
(Drosophila melanogaster)
Insecta AlCR2 37
  • 39 (a)
Drostar1 37
  • 37 (a)
Species with no ortholog for SSTR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSTR1 Gene

ENSEMBL:
Gene Tree for SSTR1 (if available)
TreeFam:
Gene Tree for SSTR1 (if available)

Paralogs for SSTR1 Gene

genes like me logo Genes that share paralogs with SSTR1: view

Variants for SSTR1 Gene

Sequence variations from dbSNP and Humsavar for SSTR1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2803939 -- 38,206,688(-) AATGC(C/T)TTTTA upstream-variant-2KB
rs10147411 -- 38,211,575(+) TCCCT(C/T)ACCCA utr-variant-3-prime
rs4073844 -- 38,208,330(+) TTTGC(A/G)AATGG intron-variant
rs4073845 -- 38,208,447(+) GCTTA(G/T)GGCCA utr-variant-5-prime
rs4143959 -- 38,212,064(+) TCTTA(C/T)TATAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SSTR1 Gene

Variant ID Type Subtype PubMed ID
nsv832773 CNV Loss 17160897

Variation tolerance for SSTR1 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SSTR1 Gene

Disorders for SSTR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SSTR1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acromegaly
  • somatotroph adenoma
medullary thyroid carcinoma, familial
  • medullary thyroid carcinoma
pseudotumor cerebri
  • benign intracran. hypt.
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search SSTR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSTR1

Genetic Association Database (GAD)
SSTR1
Human Genome Epidemiology (HuGE) Navigator
SSTR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSTR1
genes like me logo Genes that share disorders with SSTR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSTR1 Gene

Publications for SSTR1 Gene

  1. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. (PMID: 1346068) Yamada Y. … Seino S. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23 67
  2. Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. (PMID: 8449518) Yamada Y. … Bell G.I. (Genomics 1993) 2 3 23
  3. Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells. (PMID: 19070659) Watt H.L. … Kumar U. (Cell. Signal. 2009) 3 23
  4. Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes. (PMID: 19106227) Minsel I. … Paulsen F.P. (Endocrinology 2009) 3 23
  5. Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas. (PMID: 19318729) Tateno T. … Hirata Y. (Endocr. J. 2009) 3 23

Products for SSTR1 Gene

Sources for SSTR1 Gene

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