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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SST Gene

protein-coding   GIFtS: 64
GCID: GC03M187386

Somatostatin

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
somatostatin1 2
prepro-somatostatin1 2
somatostatin-141 2
somatostatin-281 2
Growth Hormone Release-Inhibiting Factor2 3
SMST2

External Ids:    HGNC: 113291   Entrez Gene: 67502   Ensembl: ENSG000001570057   OMIM: 1824505   UniProtKB: P612783   

Export aliases for SST gene to outside databases

Previous GC identifers: GC03M184201 GC03M188648 GC03M188788 GC03M188707 GC03M188869 GC03M184791


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SST Gene:
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single
preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of
numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is
an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid
stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of
neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. (provided
by RefSeq, Jul 2008)

GeneCards Summary for SST Gene: 
SST (somatostatin) is a protein-coding gene. Diseases associated with SST include portal hypertension, and somatostatinoma, and among its related super-pathways are GPCR ligand binding and Signaling by GPCR. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: SMS_HUMAN, P61278
Function: Somatostatin inhibits the release of somatotropin

summary for SST Gene:
Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two
biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on
neurotransmission, secretion and proliferation. The somatostatin receptor family consists of five subtypes,
sst1-5, each differentially distributed throughout the central nervous system and periphery. Endogenous
somatostatin receptor ligands include somatostatin-14 and somatostatin-28. Somatostatin receptors have
diverse biological functions due to their varied distribution and the fact that they couple to different
second messengers. They couple to adenylyl cyclase, PLC, K+ channels, Ca2+ channels and others. Somatostatin
receptors in the hypothalamus are involved in the regulation of growth hormone secretion. Other hormones
regulated by somatostatin receptors include thyrotropin and prolactin. Somatostatin has antiproliferative
effects via stimulation of protein tyrosine phosphatase activity and of the MAPK signaling cascade, with
subsequent induction of G1 cell cycle arrest (sst1, sst4, sst5) and promotion of apoptosis (sst2, sst3). It
also exhibits antiangiogenic activity via activation of sst3. Somatostatin regulates neuronal activity by
regulating AMPA/kainate-mediated responses to glutamate. Different sst subtypes have opposing effects in
this system. Somatostatin receptors also play a role in blood glucose homeostasis; sst5 receptors in the
pancreatic beta-cells stimulate insulin secretion, whilst sst2 receptors are involved in glucagon secretion
from alpha-cells. In addition, sst2 receptors inhibit gastric acid secretion and peristalsis in the jejunum.

Gene Wiki entry for SST (Somatostatin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SST gene promoter:
         CREB   Nkx3-1 v4   PPAR-gamma1   deltaCREB   PPAR-gamma2   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSST promoter sequence
   Search SABiosciences Chromatin IP Primers for SST

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q28

SST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SST gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M187386:  view genomic region     (about GC identifiers)

Start:
187,386,694 bp from pter      End:
187,388,201 bp from pter
Size:
1,508 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SMS_HUMAN, P61278 (See protein sequence)
Recommended Name: Somatostatin precursor  
Size: 116 amino acids; 12736 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for SST:
1P2W (3D)    
Secondary accessions: B2R5G3 P01166

Explore the universe of human proteins at neXtProt for SST: NX_P61278

Explore proteomics data for SST at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61278

  • SST Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SST Protein Expression
    REFSEQ proteins: NP_001039.1  
    ENSEMBL proteins: 
     ENSP00000287641  
    Reactome Protein details: P61278
    Human Recombinant Protein Products for SST: 
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    Novus Biologicals SST Protein
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    ProSpec Recombinant Protein for SST
    Cloud-Clone Corp. Proteins for SST 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9437026
    GO:0043025neuronal cell body IEA--

    SST for ontologies           About GeneDecksing



    SST Antibody Products: 
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    Assay Products for SST: 
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    GenScript Custom Assay Services for SST
    Browse Enzo Life Sciences for kits & assays
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    Cloud-Clone Corp. CLIAs for SST


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR018142 Somatostatin/Cortistatin_C
     IPR004250 Somatostatin

    Graphical View of Domain Structure for InterPro Entry P61278

    ProtoNet protein and cluster: P61278

    UniProtKB/Swiss-Prot: SMS_HUMAN, P61278
    Similarity: Belongs to the somatostatin family


    SST for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMS_HUMAN, P61278
    Function: Somatostatin inhibits the release of somatotropin

         Genatlas biochemistry entry for SST:
    somatostatin

         Summary:
    During embryonic development, SST as signaling molecule is secreted from the following cells: Delta Cells in Islets of Langerhans It affects the following cells: Biliary Epithelial Cells in Intrahepatic Biliary Tree

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS9886848
         
    SST for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SST:
     Decreased G3BP1 protein expres  Increased G2M DNA content  Increased number of mitotic ce 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sst):
     behavior/neurological  digestive/alimentary  growth/size  homeostasis/metabolism  immune system 
     nervous system  no phenotypic analysis  normal 

    SST for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SST: Ssttm1Ute Ssttm1Low

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SST 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SST 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SST 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SST
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    hsa-miR-576-5p hsa-miR-590-3p hsa-miR-197 hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidSST 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SST (NM_001048)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SST


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SST About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Gastric acid secretion
    Gastric acid secretion0.34
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SST
        SIDS Susceptibility Pathways

    5/7        Reactome Pathways for SST (see all 7)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for SST):
        Gastric acid secretion


    SST for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for SST (P612783 ENSP000002876414) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSTR1P308723, ENSP000002673774I2D: score=1 STRING: ENSP00000267377
    SSTR2P308743, ENSP000003501984I2D: score=1 STRING: ENSP00000350198
    SSTR3P327453, ENSP000003301384I2D: score=2 STRING: ENSP00000330138
    SSTR4P313913, ENSP000002550084I2D: score=1 STRING: ENSP00000255008
    SSTR5P353463, ENSP000002938974I2D: score=1 STRING: ENSP00000293897
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid ----
    GO:0006972hyperosmotic response IEA--
    GO:0007166cell surface receptor signaling pathway TAS9437026
    GO:0007186G-protein coupled receptor signaling pathway TAS8405411
    GO:0007267cell-cell signaling TAS6145156

    SST for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SST for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SST available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    CYN 154806Selective sst2 antagonist[183658-72-2]
    (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Potent and selective sst2 agonist[208706-12-1]

    UniProtKB/Swiss-Prot: SMS_HUMAN, P61278
    Pharmaceutical: A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin
    (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic
    treatment of carcinoid tumors and vasoactive intestinal peptide tumors

    1 HMDB Compound for SST    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 30)60-23-1--

    1 DrugBank Compound for SST    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 19)60-23-1targetbinder2901134 6142843 11752352 4080089 2653642

    10/119 Novoseek inferred chemical compound relationships for SST gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 97.6 1565 8527611 (8), 11380324 (7), 15647641 (7), 11269891 (7) (see all 99)
    lanreotide 95.3 236 10526255 (6), 10537142 (5), 12807513 (5), 18494832 (3) (see all 99)
    111in-pentetreotide 91.2 71 7975760 (3), 11787852 (3), 7908220 (2), 8683311 (1) (see all 57)
    pegvisomant 89.7 62 17427111 (3), 16498061 (2), 18611977 (2), 19763127 (2) (see all 44)
    vapreotide 86.9 42 19708854 (2), 1354449 (2), 7511473 (2), 11275699 (2) (see all 33)
    tyr-3-octreotide 85.7 34 10537142 (5), 10398816 (2), 1975618 (2), 9662587 (1) (see all 20)
    somatuline 85.5 20 1973071 (2), 11022177 (2), 7535186 (2), 7908838 (1) (see all 15)
    pasireotide 84.3 27 18957506 (2), 18041687 (2), 17113654 (1), 19845567 (1) (see all 18)
    terlipressin 81.9 128 15743361 (8), 15955217 (8), 16998289 (6), 8898643 (6) (see all 66)
    pentetreotide 80 12 8099808 (2), 11952044 (1), 10229898 (1), 9669296 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about SST / SMS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SST gene: 
    NM_001048.3  

    Unigene Cluster for SST:

    Somatostatin
    Hs.12409  [show with all ESTs]
    Unigene Representative Sequence: BI918626
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000287641(uc003frn.3)

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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate SST:
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK312177.1 BC032625.1 

    6 DOTS entries:

    DT.97806115  DT.100815862  DT.412989  DT.120879761  DT.100815860  DT.100815861 

    24/365 AceView cDNA sequences (see all 365):

    BM353617 BU952427 CA950934 BM272100 BU949362 BQ787935 BM353892 BI438466 
    BM352552 BM352214 CA868574 CA942896 BU074907 BU784617 BQ777416 BQ788068 
    BU949031 BM311742 CA866683 BU078902 CA942700 BQ777392 BM314729 CA866754 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SST expression in normal human tissues (normalized intensities)      SST embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGGAGAATT
    SST Expression
    About this image


    SST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 11 entries
             Delta Cells Islets of Langerhans
             Islets of Langerhans
             Beta-like cells ( Serum-free protocol to generate islet clusters from embryonic...
             Pancreatic Islet   
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Human Hippocampal Astrocytes   
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             Human Keratocyte (HK)   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   

    See SST Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SST

    SOURCE GeneReport for Unigene cluster: Hs.12409
        SABiosciences Expression via Pathway-Focused PCR Arrays including SST: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SST gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sst1 , 5 somatostatin1, 5 90.52(n)1
    96.55(a)1
      16 (15.00 cM)5
    206041  NM_009215.11  NP_033241.11 
     238895815 
    chicken
    (Gallus gallus)
    Aves SST1 somatostatin 82.18(n)
    87.93(a)
      396279  NM_205336.1  NP_990667.1 
    lizard
    (Anolis carolinensis)
    Reptilia SST6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343730.1(4342-23375)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135932 Xenopus laevis somatostatin 1b precursor, mRNA, complete more 76.41(n)    AY319522.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sst12 somatostatin 1 78.62(n)   326018  AF435965.1 


    ENSEMBL Gene Tree for SST (if available)
    TreeFam Gene Tree for SST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/98 SNPs in SST are shown (see all 98)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs604847491,2
    F--187386326(+) CATATA/GTTATG 1 -- ds50010--------
    rs358806161,2
    C--187386396(-) TATTGA/CAATGA 1 -- ds50015Minor allele frequency- C:0.00NA EU CSAM EA 380
    rs352932761,2
    C,F--187386505(-) TAATTT/GCACAT 1 -- ds50016Minor allele frequency- G:0.01NA EU CSAM EA WA 498
    rs98221311,2
    C,F,H--187386570(+) ATTGCC/TACCGA 1 -- ds50019Minor allele frequency- T:0.02EA NS NA EU CSAM WA 796
    rs340266171,2
    C,F--187386573(-) TTCTCC/G/TGTGGC 1 -- ds50016NA EU CSAM EA 500
    rs1871958011,2
    C--187386632(+) TACTGA/GAACCG 1 -- ds50010--------
    rs49885141,2
    C,F,H--187386831(+) TGATAT/CGGACA 1 -- ut31 ese329Minor allele frequency- C:0.19NA EU CSAM EA NS WA 3473
    rs2013286561,2
    --187386958(+) AGCCTC/TATTTC 2 I M mis10--------
    rs355171861,2
    C,F--187386972(-) CTGCTG/AAGCAG 2 /K /E mis11Minor allele frequency- A:0.00NA 4552
    rs2008858161,2
    --187386984(+) CTGGGA/GCAGAT 2 P S mis10--------

    HapMap Linkage Disequilibrium report for SST (187386694 - 187388201 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SST: --

    Human Gene Mutation Database (HGMD): SST
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SST
    DNA2.0 Custom Variant and Variant Library Synthesis for SST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182450    OMIM disorders: --

    20/261 diseases for SST (see all 261):    About MalaCards
    portal hypertension    somatostatinoma    carcinoid syndrome    chylous ascites
    duodenal somatostatinoma    pancreatic somatostatinoma    gastric antral vascular ectasia    chylothorax, congenital
    neuroendocrine tumor    vipoma    islet cell tumor    gigantism
    nelson syndrome    apudoma    somatostatin analog, resistance to    skull base meningioma
    neuroblastoma 2    blue rubber bleb nevus syndrome    duodenum cancer    non-functioning pituitary adenoma

    20/32 diseases from the University of Copenhagen DISEASES database for SST (see all 32):
    Acromegaly     Neuroendocrine tumor     Adenoma     Pancreatic cancer
    Diarrhea     Pituitary adenoma     Hypoglycemia     Hyperglycemia
    Diabetes mellitus     Esophageal varix     Pancreatitis     Peptic ulcer
    Cushing's syndrome     Thyroid cancer     Hyperinsulinemic hypoglycemia     Hyperinsulinism
    Varicose veins     Carcinoma     Intestinal disease     Liver disease

    SST for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/97 Novoseek inferred disease relationships for SST gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acromegaly 93.4 388 16776333 (5), 11888834 (4), 17311857 (4), 18031313 (4) (see all 99)
    neuroendocrine tumors 90.7 177 9408151 (4), 9002775 (3), 1359688 (3), 15151956 (3) (see all 99)
    carcinoid 88.7 209 9002775 (3), 7574789 (3), 18049175 (3), 9622077 (3) (see all 99)
    pituitary adenoma 85.2 129 12807513 (5), 15281350 (4), 10526255 (3), 16216913 (3) (see all 92)
    somatostatinoma 84.9 28 9189135 (2), 16105971 (2), 1686137 (1), 1969977 (1) (see all 23)
    serotonin syndrome 81.6 52 14699693 (3), 1377097 (2), 8977344 (2), 8625251 (2) (see all 46)
    pituitary tumors 81.5 57 16452215 (3), 20068168 (3), 18243520 (2), 1362150 (2) (see all 44)
    vipoma 81.4 13 8197564 (2), 2177234 (1), 1685674 (1), 15646540 (1) (see all 12)
    gastrinoma 81.2 20 9239629 (3), 14564638 (1), 2303679 (1), 1357826 (1) (see all 17)
    glucagonoma 80.4 14 8813473 (1), 1679271 (1), 12472080 (1), 14718149 (1) (see all 14)

    Genetic Association Database (GAD): SST
    Human Genome Epidemiology (HuGE) Navigator: SST (30 documents)

    Export disorders for SST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SST gene, integrated from 9 sources (see all 3585):
    (articles sorted by number of sources associating them with SST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of the human somatostatin I gene. (PubMed id 6142531)1, 2, 3 Shen L.-P. and Rutter W.J. (1984)
    2. Human somatostatin I: sequence of the cDNA. (PubMed id 6126875)1, 2, 3 Shen L.-P.... Rutter W.J. (1982)
    3. Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. (PubMed id 19423539)1, 4, 9 Johansson M....Kaaks R. (2009)
    4. Polymorphisms in genes involved in GH1 release and their association with breast cancer risk. (PubMed id 16606630)1, 4, 9 Wagner K....Forsti A. (2006)
    5. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    6. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
    7. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    8. Eighteen insulin-like growth factor pathway genes, ci rculating levels of IGF-I and its binding protein, and risk of prostate and bre ast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (2010)
    9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    10. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolis m and breast cancer risk in the NCI breast and prostate cancer cohort consortiu m. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6750 HGNC: 11329 AceView: SST Ensembl:ENSG00000157005 euGenes: HUgn6750
    ECgene: SST Kegg: 6750 H-InvDB: SST

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SST Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Somatostatin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SST gene:
    Search GeneIP for patents involving SST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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     Regulatory tfbs in SST promoter
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