Aliases for SST Gene
External Ids for SST Gene
Previous GeneCards Identifiers for SST Gene
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for SST Gene
SST (Somatostatin) is a Protein Coding gene. Diseases associated with SST include Islet Cell Tumor and Somatostatinoma. Among its related pathways are Salivary secretion and BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation. Gene Ontology (GO) annotations related to this gene include hormone activity.
UniProtKB/Swiss-Prot for SST Gene
Somatostatin inhibits the release of somatotropin.
Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.