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Aliases for SST Gene

Aliases for SST Gene

  • Somatostatin 2 3
  • Growth Hormone Release-Inhibiting Factor 3 4
  • Prepro-Somatostatin 2 3
  • Somatostatin-14 2 3
  • Somatostatin-28 2 3
  • SMST 3

External Ids for SST Gene

Summaries for SST Gene

Entrez Gene Summary for SST Gene

  • The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for SST Gene

SST (Somatostatin) is a Protein Coding gene. Diseases associated with SST include pancreatic somatostatinoma and somatostatinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for SST Gene

  • Somatostatin inhibits the release of somatotropin

Tocris Summary for SST Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and proliferation. The somatostatin receptor family consists of five subtypes, sst1-5, each differentially distributed throughout the central nervous system and periphery. Endogenous somatostatin receptor ligands include somatostatin-14 and somatostatin-28. Somatostatin receptors have diverse biological functions due to their varied distribution and the fact that they couple to different second messengers. They couple to adenylyl cyclase, PLC, K+ channels, Ca2+ channels and others. Somatostatin receptors in the hypothalamus are involved in the regulation of growth hormone secretion. Other hormones regulated by somatostatin receptors include thyrotropin and prolactin. Somatostatin has antiproliferative effects via stimulation of protein tyrosine phosphatase activity and of the MAPK signaling cascade, with subsequent induction of G1 cell cycle arrest (sst1, sst4, sst5) and promotion of apoptosis (sst2, sst3). It also exhibits antiangiogenic activity via activation of sst3. Somatostatin regulates neuronal activity by regulating AMPA/kainate-mediated responses to glutamate. Different sst subtypes have opposing effects in this system. Somatostatin receptors also play a role in blood glucose homeostasis; sst5 receptors in the pancreatic beta-cells stimulate insulin secretion, whilst sst2 receptors are involved in glucagon secretion from alpha-cells. In addition, sst2 receptors inhibit gastric acid secretion and peristalsis in the jejunum.

Gene Wiki entry for SST Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SST Gene

Genomics for SST Gene

Genomic Location for SST Gene

Start:
187,668,906 bp from pter
End:
187,670,413 bp from pter
Size:
1,508 bases
Orientation:
Minus strand

Genomic View for SST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SST Gene

Regulatory Elements for SST Gene

Proteins for SST Gene

  • Protein details for SST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61278-SMS_HUMAN
    Recommended name:
    Somatostatin
    Protein Accession:
    P61278
    Secondary Accessions:
    • B2R5G3
    • P01166

    Protein attributes for SST Gene

    Size:
    116 amino acids
    Molecular mass:
    12736 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SST Gene

neXtProt entry for SST Gene

Proteomics data for SST Gene at MOPED

Post-translational modifications for SST Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn61

Other Protein References for SST Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SST Gene

Domains for SST Gene

Gene Families for SST Gene

HGNC:

Protein Domains for SST Gene

Suggested Antigen Peptide Sequences for SST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61278

UniProtKB/Swiss-Prot:

SMS_HUMAN
Family:
  • Belongs to the somatostatin family.:
    • P61278
genes like me logo Genes that share domains with SST: view

Function for SST Gene

Molecular function for SST Gene

GENATLAS Biochemistry: somatostatin
UniProtKB/Swiss-Prot Function: Somatostatin inhibits the release of somatotropin

LifeMap Function Summary for SST Gene

During embryonic development, SST as signaling molecule is secreted from the following cells
It affects the following cells:

Gene Ontology (GO) - Molecular Function for SST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 9886848
genes like me logo Genes that share ontologies with SST: view
genes like me logo Genes that share phenotypes with SST: view

Animal Models for SST Gene

MGI Knock Outs for SST:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SST Gene

Localization for SST Gene

Subcellular locations from UniProtKB/Swiss-Prot for SST Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SST Gene COMPARTMENTS Subcellular localization image for SST gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
endosome 1

Gene Ontology (GO) - Cellular Components for SST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9437026
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with SST: view

Pathways for SST Gene

genes like me logo Genes that share pathways with SST: view

Pathways by source for SST Gene

Gene Ontology (GO) - Biological Process for SST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001101 response to acid chemical --
GO:0006972 hyperosmotic response IEA --
GO:0007166 cell surface receptor signaling pathway TAS 9437026
GO:0007186 G-protein coupled receptor signaling pathway TAS 8405411
GO:0007267 cell-cell signaling TAS 6145156
genes like me logo Genes that share ontologies with SST: view

Compounds for SST Gene

UniProtKB/Swiss-Prot:

P61278-SMS_HUMAN
Pharmaceutical: A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors

(5) Tocris Compounds for SST Gene

Compound Action Cas Number
(1R,1S,3R/1R,1R,3S)-L-054,264 Potent and selective sst2 agonist [208706-12-1]
Cyclosomatostatin Non-selective sst receptor antagonist [84211-54-1]
CYN 154806 Selective sst2 antagonist [183658-72-2]
Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
Somatostatin Influences growth hormone release [51110-01-1]

(1) HMDB Compounds for SST Gene

Compound Synonyms Cas Number PubMed IDs
Cysteamine
  • (2-Mercaptoethyl)amine
60-23-1

(1) Drugbank Compounds for SST Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cysteamine
  • (2-Mercaptoethyl)amine
60-23-1 target binder

(119) Novoseek inferred chemical compound relationships for SST Gene

Compound -log(P) Hits PubMed IDs
octreotide 97.6 337
lanreotide 95.3 134
111in-pentetreotide 91.2 62
pegvisomant 89.7 53
vapreotide 86.9 40
genes like me logo Genes that share compounds with SST: view

Transcripts for SST Gene

mRNA/cDNA for SST Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(365) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SST Gene

Somatostatin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SST Gene

No ASD Table

Relevant External Links for SST Gene

GeneLoc Exon Structure for
SST
ECgene alternative splicing isoforms for
SST

Expression for SST Gene

mRNA expression in normal human tissues for SST Gene

mRNA differential expression in normal tissues according to GTEx for SST Gene

This gene is overexpressed in Brain - Hypothalamus (10.8), Pancreas (8.7), Stomach (5.2), and Brain - Putamen (basal ganglia) (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SST Gene

SOURCE GeneReport for Unigene cluster for SST Gene Hs.12409

genes like me logo Genes that share expressions with SST: view

No data available for mRNA Expression by UniProt/SwissProt for SST Gene

Orthologs for SST Gene

This gene was present in the common ancestor of chordates.

Orthologs for SST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SST 35
  • 99.71 (n)
  • 99.14 (a)
SST 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SST 35
  • 94.83 (n)
  • 98.28 (a)
SST 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SST 35
  • 95.98 (n)
  • 98.28 (a)
SST 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sst 35
  • 90.52 (n)
  • 96.55 (a)
Sst 16
Sst 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SST 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SST 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sst 35
  • 90.23 (n)
  • 96.55 (a)
chicken
(Gallus gallus)
Aves SST 35
  • 82.18 (n)
  • 87.93 (a)
SST 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SST 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13593 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sst 35
  • 71.88 (n)
  • 75.65 (a)
Str.14307 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14049 35
zebrafish
(Danio rerio)
Actinopterygii sst1 35
sst1.1 35
  • 67.54 (n)
  • 68.42 (a)
sst1.1 36
  • 70 (a)
OneToOne
Species with no ortholog for SST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SST Gene

ENSEMBL:
Gene Tree for SST (if available)
TreeFam:
Gene Tree for SST (if available)

Paralogs for SST Gene

No data available for Paralogs for SST Gene

Variants for SST Gene

Sequence variations from dbSNP and Humsavar for SST Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs3755792 -- 187,672,173(+) GAAAC(A/G)AGGAT upstream-variant-2KB
rs3834203 -- 187,672,342(+) TCCTT(-/A)ACCTT upstream-variant-2KB
rs4988512 -- 187,670,671(+) ACACA(A/T)GCACA upstream-variant-2KB
rs4988513 -- 187,670,108(+) AGGCT(C/T)AGGGA intron-variant
rs4988514 -- 187,669,043(+) TGATA(C/T)GGACA utr-variant-3-prime

Relevant External Links for SST Gene

HapMap Linkage Disequilibrium report
SST
Human Gene Mutation Database (HGMD)
SST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SST Gene

Disorders for SST Gene

(97) Novoseek inferred disease relationships for SST Gene

Disease -log(P) Hits PubMed IDs
acromegaly 93.4 174
neuroendocrine tumors 90.7 124
carcinoid 88.7 138
pituitary adenoma 85.2 121
somatostatinoma 84.9 25

Relevant External Links for SST

Genetic Association Database (GAD)
SST
Human Genome Epidemiology (HuGE) Navigator
SST
genes like me logo Genes that share disorders with SST: view

No data available for UniProtKB/Swiss-Prot for SST Gene

Publications for SST Gene

  1. Human somatostatin I: sequence of the cDNA. (PMID: 6126875) Shen L.-P. … Rutter W.J. (Proc. Natl. Acad. Sci. U.S.A. 1982) 2 3 4
  2. Sequence of the human somatostatin I gene. (PMID: 6142531) Shen L.-P. … Rutter W.J. (Science 1984) 2 3 4
  3. Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. (PMID: 16211223) Hall G.H. … Atkin S.L. (Int. J. Oncol. 2005) 3 23
  4. The somatostatin-28(1-12)-NPAMAP sequence: an essential helical-promoting motif governing prosomatostatin processing at mono- and dibasic sites. (PMID: 11814357) Brakch N. … Rholam M. (Biochemistry 2002) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SST Gene

Sources for SST Gene

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