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SST Gene

protein-coding   GIFtS: 64
GCID: GC03M187386

Somatostatin

  See SST-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
somatostatin1 2
prepro-somatostatin1 2
somatostatin-141 2
somatostatin-281 2
Growth Hormone Release-Inhibiting Factor2 3
SMST2

External Ids:    HGNC: 113291   Entrez Gene: 67502   Ensembl: ENSG000001570057   OMIM: 1824505   UniProtKB: P612783   

Export aliases for SST gene to outside databases

Previous GC identifers: GC03M184201 GC03M188648 GC03M188788 GC03M188707 GC03M188869 GC03M184791


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SST Gene:
The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single
preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of
numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is
an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid
stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of
neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. (provided
by RefSeq, Jul 2008)

GeneCards Summary for SST Gene:
SST (somatostatin) is a protein-coding gene. Diseases associated with SST include carcinoid syndrome, and somatostatinoma. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: SMS_HUMAN, P61278
Function: Somatostatin inhibits the release of somatotropin

summary for SST Gene:
Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two
biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on
neurotransmission, secretion and proliferation. The somatostatin receptor family consists of five subtypes,
sst1-5, each differentially distributed throughout the central nervous system and periphery. Endogenous
somatostatin receptor ligands include somatostatin-14 and somatostatin-28. Somatostatin receptors have
diverse biological functions due to their varied distribution and the fact that they couple to different
second messengers. They couple to adenylyl cyclase, PLC, K+ channels, Ca2+ channels and others. Somatostatin
receptors in the hypothalamus are involved in the regulation of growth hormone secretion. Other hormones
regulated by somatostatin receptors include thyrotropin and prolactin. Somatostatin has antiproliferative
effects via stimulation of protein tyrosine phosphatase activity and of the MAPK signaling cascade, with
subsequent induction of G1 cell cycle arrest (sst1, sst4, sst5) and promotion of apoptosis (sst2, sst3). It
also exhibits antiangiogenic activity via activation of sst3. Somatostatin regulates neuronal activity by
regulating AMPA/kainate-mediated responses to glutamate. Different sst subtypes have opposing effects in
this system. Somatostatin receptors also play a role in blood glucose homeostasis; sst5 receptors in the
pancreatic beta-cells stimulate insulin secretion, whilst sst2 receptors are involved in glucagon secretion
from alpha-cells. In addition, sst2 receptors inhibit gastric acid secretion and peristalsis in the jejunum.

Gene Wiki entry for SST (Somatostatin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SST gene promoter:
         CREB   Nkx3-1 v4   PPAR-gamma1   deltaCREB   PPAR-gamma2   Gfi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSST promoter sequence
   Search Chromatin IP Primers for SST

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SST


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q28   Ensembl cytogenetic band:  3q27.3   HGNC cytogenetic band: 3q28

SST Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SST gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M187386:  view genomic region     (about GC identifiers)

Start:
187,386,694 bp from pter      End:
187,388,201 bp from pter
Size:
1,508 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SMS_HUMAN, P61278 (See protein sequence)
Recommended Name: Somatostatin precursor  
Size: 116 amino acids; 12736 Da
1 PDB 3D structure from and Proteopedia for SST:
1P2W (3D)    
Secondary accessions: B2R5G3 P01166

Explore the universe of human proteins at neXtProt for SST: NX_P61278

Explore proteomics data for SST at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn61
  • Modification sites at PhosphoSitePlus

  • See SST Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001039.1  
    ENSEMBL proteins: 
     ENSP00000287641  
    Reactome Protein details: P61278

    SST Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for SST 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    2 InterPro protein domains:
     IPR018142 Somatostatin/Cortistatin_C
     IPR004250 Somatostatin

    Graphical View of Domain Structure for InterPro Entry P61278

    ProtoNet protein and cluster: P61278

    UniProtKB/Swiss-Prot: SMS_HUMAN, P61278
    Similarity: Belongs to the somatostatin family


    Find genes that share domains with SST           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SMS_HUMAN, P61278
    Function: Somatostatin inhibits the release of somatotropin

         Genatlas biochemistry entry for SST:
    somatostatin

         Summary: 
    During embryonic development, SST as signaling molecule is secreted from the following cells:
                
    Pancreas: Delta Cells (Islets of Langerhans)

    It affects the following cells:
    Liver: Biliary Epithelial Cells (Intrahepatic Biliary Tree)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS9886848
         
    Find genes that share ontologies with SST           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SST:
     Decreased G3BP1 protein expres  Increased G2M DNA content  Increased number of mitotic ce 

         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sst):
     behavior/neurological  digestive/alimentary  growth/size/body  homeostasis/metabolism  immune system 
     nervous system  no phenotypic analysis  normal 

    Find genes that share phenotypes with SST           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SST: Ssttm1Ute Ssttm1Low

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SST
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SST

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SST
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SST

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate SST:
    hsa-miR-576-5p hsa-miR-590-3p hsa-miR-197 hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidSST 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SST

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SST (NM_001048)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SST
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SST

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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10301 VA4-10836) for SST 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SMS_HUMAN, P61278: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    plasma membrane3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    golgi apparatus2
    mitochondrion2
    endosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space TAS9437026
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with SST           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SST About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Salivary secretion
    Gastric acid secretion0.34
    4SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways


    Find genes that share SuperPaths with SST           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SST
        SIDS Susceptibility Pathways

    2 Reactome Pathways for SST
        Peptide ligand-binding receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for SST):
        Gastric acid secretion

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SST: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SST

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SST (P612783 ENSP000002876414) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSTR1P308723, ENSP000002673774I2D: score=1 STRING: ENSP00000267377
    SSTR2P308743, ENSP000003501984I2D: score=1 STRING: ENSP00000350198
    SSTR3P327453, ENSP000003301384I2D: score=2 STRING: ENSP00000330138
    SSTR4P313913, ENSP000002550084I2D: score=1 STRING: ENSP00000255008
    SSTR5P353463, ENSP000002938974I2D: score=1 STRING: ENSP00000293897
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001101response to acid ----
    GO:0006972hyperosmotic response IEA--
    GO:0007166cell surface receptor signaling pathway TAS9437026
    GO:0007186G-protein coupled receptor signaling pathway TAS8405411
    GO:0007267cell-cell signaling TAS6145156

    Find genes that share ontologies with SST           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for SST available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SomatostatinInfluences growth hormone release[51110-01-1]
    Octreotide sst2, sst3 and sst5 agonist [79517-01-4]
    CyclosomatostatinNon-selective sst receptor antagonist[84211-54-1]
    CYN 154806Selective sst2 antagonist[183658-72-2]
    (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Potent and selective sst2 agonist[208706-12-1]

    UniProtKB/Swiss-Prot: SMS_HUMAN, P61278
    Pharmaceutical: A synthetic analog known as octreotide or SMS 201-995 is available under the name Sandostatin
    (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic
    treatment of carcinoid tumors and vasoactive intestinal peptide tumors

    1 HMDB Compound for SST    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 30)60-23-1--

    1 DrugBank Compound for SST    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cysteamine(2-Mercaptoethyl)amine (see all 19)60-23-1targetbinder2901134 6142843 11752352 4080089 2653642

    Selected Novoseek inferred chemical compound relationships for SST gene (see all 119)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octreotide 97.6 1565 8527611 (8), 11380324 (7), 15647641 (7), 11269891 (7) (see all 99)
    lanreotide 95.3 236 10526255 (6), 10537142 (5), 12807513 (5), 18494832 (3) (see all 99)
    111in-pentetreotide 91.2 71 7975760 (3), 11787852 (3), 7908220 (2), 8683311 (1) (see all 57)
    pegvisomant 89.7 62 17427111 (3), 16498061 (2), 18611977 (2), 19763127 (2) (see all 44)
    vapreotide 86.9 42 19708854 (2), 1354449 (2), 7511473 (2), 11275699 (2) (see all 33)
    tyr-3-octreotide 85.7 34 10537142 (5), 10398816 (2), 1975618 (2), 9662587 (1) (see all 20)
    somatuline 85.5 20 1973071 (2), 11022177 (2), 7535186 (2), 7908838 (1) (see all 15)
    pasireotide 84.3 27 18957506 (2), 18041687 (2), 17113654 (1), 19845567 (1) (see all 18)
    terlipressin 81.9 128 15743361 (8), 15955217 (8), 16998289 (6), 8898643 (6) (see all 66)
    pentetreotide 80 12 8099808 (2), 11952044 (1), 10229898 (1), 9669296 (1) (see all 9)



    Find genes that share compounds with SST           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SST gene: 
    NM_001048.3  

    Unigene Cluster for SST:

    Somatostatin
    Hs.12409  [show with all ESTs]
    Unigene Representative Sequence: BI918626
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000287641(uc003frn.3)
    miRNA
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    hsa-miR-576-5p hsa-miR-590-3p hsa-miR-197 hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidSST 3' UTR sequence
    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AK312177.1 BC032625.1 

    6 DOTS entries:

    DT.97806115  DT.100815862  DT.412989  DT.120879761  DT.100815860  DT.100815861 

    Selected AceView cDNA sequences (see all 365):

    BQ631240 BQ777416 CA844094 BQ271833 CA866683 BM353892 CA841084 CB068296 
    CA950687 CB177528 CA947076 CA842138 BQ269649 CA776482 BU786348 CA842767 
    BM503997 BQ776941 CA868574 BQ287823 BQ269420 BU952101 CA867249 CA841644 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SST expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACGGAGAATT
    SST Expression
    About this image


    SST expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 10 entries
             Delta Cells Islets of Langerhans
             Islets of Langerhans
             Pancreatic-like cells
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             Ventral/hypothalamic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    SST Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SST Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12409
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SST: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat
              Embryonic Stem Cells in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SST

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SST gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sst1 , 5 somatostatin1, 5 90.52(n)1
    96.55(a)1
      16 (15.00 cM)5
    206041  NM_009215.11  NP_033241.11 
     238895815 
    chicken
    (Gallus gallus)
    Aves SST1 somatostatin 82.18(n)
    87.93(a)
      396279  NM_205336.1  NP_990667.1 
    lizard
    (Anolis carolinensis)
    Reptilia SST6
    somatostatin
    78(a)
    1 ↔ 1
    GL343730.1(4342-23375)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135932 Xenopus laevis somatostatin 1b precursor, mRNA, complete more 76.41(n)    AY319522.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sst12 somatostatin 1 78.62(n)   326018  AF435965.1 


    ENSEMBL Gene Tree for SST (if available)
    TreeFam Gene Tree for SST (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SST (see all 98)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs604847491,2
    F--187386326(+) CATATA/GTTATG 1 -- ds50010--------
    rs358806161,2
    C--187386396(-) TATTGA/CAATGA 1 -- ds50015Minor allele frequency- C:0.00NA EU CSAM EA 380
    rs352932761,2
    C,F--187386505(-) TAATTT/GCACAT 1 -- ds50016Minor allele frequency- G:0.01NA EU CSAM EA WA 498
    rs98221311,2
    C,F,H--187386570(+) ATTGCC/TACCGA 1 -- ds50019Minor allele frequency- T:0.02EA NS NA EU CSAM WA 796
    rs340266171,2
    C,F--187386573(-) TTCTCC/G/TGTGGC 1 -- ds50016NA EU CSAM EA 500
    rs1871958011,2
    C--187386632(+) TACTGA/GAACCG 1 -- ds50010--------
    rs49885141,2
    C,F,H--187386831(+) TGATAT/CGGACA 1 -- ut31 ese329Minor allele frequency- C:0.19NA EU CSAM EA NS WA 3473
    rs2013286561,2
    --187386958(+) AGCCTC/TATTTC 2 I M mis10--------
    rs355171861,2
    C,F--187386972(-) CTGCTG/AAGCAG 2 /K /E mis11Minor allele frequency- A:0.00NA 4552
    rs2008858161,2
    --187386984(+) CTGGGA/GCAGAT 2 P S mis10--------

    HapMap Linkage Disequilibrium report for SST (187386694 - 187388201 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SST: --
    Human Gene Mutation Database (HGMD): SST
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SST
    DNA2.0 Custom Variant and Variant Library Synthesis for SST

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 182450    OMIM disorders: --

    Selected diseases for SST (see all 66):    
    About MalaCards
    carcinoid syndrome    somatostatinoma    esophageal varix    duodenal somatostatinoma
    chylothorax, congenital    secretory diarrhea    pancreatic somatostatinoma    chylous ascites
    pituitary-dependent cushing's disease    neuroendocrine tumor    somatostatin analog    gastric antral vascular ectasia
    nelson syndrome    skull base meningioma    neuroblastoma 2    vipoma
    intestinal neuroendocrine tumor    apudoma    pancreatic cholera    gigantism

    Selected diseases from the University of Copenhagen DISEASES database for SST (see all 32):
    Acromegaly     Neuroendocrine tumor     Adenoma     Pancreatic cancer
    Diarrhea     Pituitary adenoma     Hypoglycemia     Hyperglycemia
    Diabetes mellitus     Esophageal varix     Pancreatitis     Peptic ulcer
    Cushing's syndrome     Thyroid cancer     Hyperinsulinemic hypoglycemia     Hyperinsulinism
    Varicose veins     Carcinoma     Intestinal disease     Liver disease

    Find genes that share disorders with SST           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SST gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acromegaly 93.4 388 16776333 (5), 11888834 (4), 17311857 (4), 18031313 (4) (see all 99)
    neuroendocrine tumors 90.7 177 9408151 (4), 9002775 (3), 1359688 (3), 15151956 (3) (see all 99)
    carcinoid 88.7 209 9002775 (3), 7574789 (3), 18049175 (3), 9622077 (3) (see all 99)
    pituitary adenoma 85.2 129 12807513 (5), 15281350 (4), 10526255 (3), 16216913 (3) (see all 92)
    somatostatinoma 84.9 28 9189135 (2), 16105971 (2), 1686137 (1), 1969977 (1) (see all 23)
    serotonin syndrome 81.6 52 14699693 (3), 1377097 (2), 8977344 (2), 8625251 (2) (see all 46)
    pituitary tumors 81.5 57 16452215 (3), 20068168 (3), 18243520 (2), 1362150 (2) (see all 44)
    vipoma 81.4 13 8197564 (2), 2177234 (1), 1685674 (1), 15646540 (1) (see all 12)
    gastrinoma 81.2 20 9239629 (3), 14564638 (1), 2303679 (1), 1357826 (1) (see all 17)
    glucagonoma 80.4 14 8813473 (1), 1679271 (1), 12472080 (1), 14718149 (1) (see all 14)

    Genetic Association Database (GAD): SST
    Human Genome Epidemiology (HuGE) Navigator: SST (30 documents)

    Export disorders for SST gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SST gene, integrated from 10 sources (see all 3586):
    (articles sorted by number of sources associating them with SST)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of the human somatostatin I gene. (PubMed id 6142531)1, 2, 3 Shen L.-P. and Rutter W.J. (Science 1984)
    2. Human somatostatin I: sequence of the cDNA. (PubMed id 6126875)1, 2, 3 Shen L.-P.... Rutter W.J. (Proc. Natl. Acad. Sci. U.S.A. 1982)
    3. Genetic variation in the SST gene and its receptors in relation to circulating levels of insulin-like growth factor-I, IGFBP3, and prostate cancer risk. (PubMed id 19423539)1, 4, 9 Johansson M....Kaaks R. (amp 2009)
    4. Polymorphisms in genes involved in GH1 release and their association with breast cancer risk. (PubMed id 16606630)1, 4, 9 Wagner K....FAPrsti A. (Carcinogenesis 2006)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    7. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    8. Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. (PubMed id 20810604)1, 4 Gu F....Kraft P. (amp 2010)
    9. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    10. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6750 HGNC: 11329 AceView: SST Ensembl:ENSG00000157005 euGenes: HUgn6750
    ECgene: SST Kegg: 6750 H-InvDB: SST

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SST Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Somatostatin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SST gene:
    Search GeneIP for patents involving SST

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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