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Aliases for SST Gene

Aliases for SST Gene

  • Somatostatin 2 3 5
  • Growth Hormone Release-Inhibiting Factor 3 4
  • Prepro-Somatostatin 2 3
  • Somatostatin-14 2 3
  • Somatostatin-28 2 3
  • SMST 3

External Ids for SST Gene

Previous GeneCards Identifiers for SST Gene

  • GC03M184201
  • GC03M188648
  • GC03M188788
  • GC03M188707
  • GC03M188869
  • GC03M187386
  • GC03M184791

Summaries for SST Gene

Entrez Gene Summary for SST Gene

  • The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for SST Gene

SST (Somatostatin) is a Protein Coding gene. Diseases associated with SST include neuroendocrine tumor and somatostatinoma. Among its related pathways are Salivary secretion and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for SST Gene

  • Somatostatin inhibits the release of somatotropin.

Tocris Summary for SST Gene

  • Somatostatin (somatotropin release inhibiting factor, SRIF) is an endogenous cyclic polypeptide with two biologically active forms. It is an abundant neuropeptide and has a wide range of physiological effects on neurotransmission, secretion and cell proliferation.

Gene Wiki entry for SST Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SST Gene

Genomics for SST Gene

Regulatory Elements for SST Gene

Enhancers for SST Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SST on UCSC Golden Path with GeneCards custom track

Genomic Location for SST Gene

Chromosome:
3
Start:
187,668,906 bp from pter
End:
187,670,413 bp from pter
Size:
1,508 bases
Orientation:
Minus strand

Genomic View for SST Gene

Genes around SST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SST Gene

Proteins for SST Gene

  • Protein details for SST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61278-SMS_HUMAN
    Recommended name:
    Somatostatin
    Protein Accession:
    P61278
    Secondary Accessions:
    • B2R5G3
    • P01166

    Protein attributes for SST Gene

    Size:
    116 amino acids
    Molecular mass:
    12736 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SST Gene

neXtProt entry for SST Gene

Proteomics data for SST Gene at MOPED

Post-translational modifications for SST Gene

  • Glycosylation at Asn 61
  • Modification sites at PhosphoSitePlus

Other Protein References for SST Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SST Gene

Domains & Families for SST Gene

Gene Families for SST Gene

Protein Domains for SST Gene

Suggested Antigen Peptide Sequences for SST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61278

UniProtKB/Swiss-Prot:

SMS_HUMAN :
  • Belongs to the somatostatin family.
Family:
  • Belongs to the somatostatin family.
genes like me logo Genes that share domains with SST: view

Function for SST Gene

Molecular function for SST Gene

GENATLAS Biochemistry:
somatostatin
UniProtKB/Swiss-Prot Function:
Somatostatin inhibits the release of somatotropin.

LifeMap Function Summary for SST Gene

During embryonic development, SST as signaling molecule is secreted from the following cells
It affects the following cells:
genes like me logo Genes that share phenotypes with SST: view

Animal Models for SST Gene

MGI Knock Outs for SST:

Animal Model Products

miRNA for SST Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SST Gene

Localization for SST Gene

Subcellular locations from UniProtKB/Swiss-Prot for SST Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SST Gene COMPARTMENTS Subcellular localization image for SST gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2
vacuole 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with SST: view

Pathways & Interactions for SST Gene

genes like me logo Genes that share pathways with SST: view

Pathways by source for SST Gene

SIGNOR curated interactions for SST Gene

Activates:

Gene Ontology (GO) - Biological Process for SST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 8405411
GO:0007267 cell-cell signaling TAS 6145156
GO:0007584 response to nutrient TAS 6145156
GO:0007586 digestion TAS 6145156
GO:0008285 negative regulation of cell proliferation TAS 9886848
genes like me logo Genes that share ontologies with SST: view

Drugs & Compounds for SST Gene

(75) Drugs for SST Gene - From: DrugBank, ClinicalTrials, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cysteamine Approved, Investigational Pharma Target, binder 26
Octreotide Approved, Investigational Pharma Full agonist, Agonist sst2, sst3 and sst5 agonist 205
Ethanol Approved Pharma 1924
Seglitide Pharma sst2 and sst5 agonist 0
interferons Pharma 2089

(50) Additional Compounds for SST Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
L-803,087 trifluoroacetate
217480-26-7
Somatostatin 1-28
74315-46-1

(5) Tocris Compounds for SST Gene

Compound Action Cas Number
L-803,087 trifluoroacetate Potent and selective sst4 agonist 217480-26-7
Octreotide sst2, sst3 and sst5 agonist 83150-76-9
Seglitide sst2 and sst5 agonist 81377-02-8
Somatostatin Influences growth hormone release 51110-01-1
Somatostatin 1-28 sst receptor agonist 74315-46-1
genes like me logo Genes that share compounds with SST: view

Transcripts for SST Gene

mRNA/cDNA for SST Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(365) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SST Gene

Somatostatin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SST Gene

No ASD Table

Relevant External Links for SST Gene

GeneLoc Exon Structure for
SST
ECgene alternative splicing isoforms for
SST

Expression for SST Gene

mRNA expression in normal human tissues for SST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SST Gene

This gene is overexpressed in Brain - Hypothalamus (x10.8), Pancreas (x8.7), Stomach (x5.2), and Brain - Putamen (basal ganglia) (x5.2).

Protein differential expression in normal tissues from HIPED for SST Gene

This gene is overexpressed in Fetal gut (29.5), Stomach (19.1), and Pancreas (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SST Gene



SOURCE GeneReport for Unigene cluster for SST Gene Hs.12409

genes like me logo Genes that share expression patterns with SST: view

Protein tissue co-expression partners for SST Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SST Gene

Orthologs for SST Gene

This gene was present in the common ancestor of chordates.

Orthologs for SST Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SST 35
  • 94.83 (n)
  • 98.28 (a)
SST 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SST 35
  • 95.98 (n)
  • 98.28 (a)
SST 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SST 36
  • 99 (a)
OneToOne
SST 35
  • 99.71 (n)
  • 99.14 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SST 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sst 36
  • 97 (a)
OneToOne
Sst 16
Sst 35
  • 90.52 (n)
  • 96.55 (a)
oppossum
(Monodelphis domestica)
Mammalia SST 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sst 35
  • 90.23 (n)
  • 96.55 (a)
chicken
(Gallus gallus)
Aves SST 36
  • 87 (a)
OneToOne
SST 35
  • 82.18 (n)
  • 87.93 (a)
lizard
(Anolis carolinensis)
Reptilia SST 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13593 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14307 35
sst 35
  • 71.88 (n)
  • 75.65 (a)
zebrafish
(Danio rerio)
Actinopterygii sst1.1 36
  • 70 (a)
OneToOne
sst1.1 35
  • 67.54 (n)
  • 68.42 (a)
sst1 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14049 35
Species with no ortholog for SST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SST Gene

ENSEMBL:
Gene Tree for SST (if available)
TreeFam:
Gene Tree for SST (if available)

Paralogs for SST Gene

No data available for Paralogs for SST Gene

Variants for SST Gene

Sequence variations from dbSNP and Humsavar for SST Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35603672 - 187,670,260(-) GCTGG(C/T)TGCGC reference, missense
rs33934967 - 187,669,234(-) ACCCA(A/C)CCAGA reference, missense
rs9822131 -- 187,668,782(+) ATTGC(C/T)ACCGA downstream-variant-500B
rs7624906 -- 187,671,848(+) TGTGC(C/T)TGTAA upstream-variant-2KB
rs58604056 -- 187,669,554(+) CACAC(A/G)CACAA intron-variant

Variation tolerance for SST Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SST Gene

HapMap Linkage Disequilibrium report
SST
Human Gene Mutation Database (HGMD)
SST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SST Gene

Disorders for SST Gene

MalaCards: The human disease database

(139) MalaCards diseases for SST Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuroendocrine tumor
  • neuroendocrine neoplasm
somatostatinoma
  • pancreatic somatostatinoma
esophageal varix
  • bleeding esophageal varices
islet cell tumor
  • pancreatic endocrine carcinoma
portal hypertension
  • hypertension, portal
- elite association - COSMIC cancer census association via MalaCards
Search SST in MalaCards View complete list of genes associated with diseases

Relevant External Links for SST

Genetic Association Database (GAD)
SST
Human Genome Epidemiology (HuGE) Navigator
SST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SST
genes like me logo Genes that share disorders with SST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SST Gene

Publications for SST Gene

  1. Sequence of the human somatostatin I gene. (PMID: 6142531) Shen L.-P. … Rutter W.J. (Science 1984) 2 3 4 67
  2. The effect of transforming growth factor beta on human neuroendocrine tumor BON cell proliferation and differentiation is mediated through somatostatin signaling. (PMID: 18567806) Leu F.P. … Niu C. (Mol. Cancer Res. 2008) 3 23
  3. Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration. (PMID: 17704349) Carrasco E. … SimA^ R. (Diabetes Care 2007) 3 23
  4. Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects. (PMID: 16043736) HernA!ndez C. … SimA^ R. (Diabetes Care 2005) 3 23
  5. Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. (PMID: 16211223) Hall G.H. … Atkin S.L. (Int. J. Oncol. 2005) 3 23

Products for SST Gene

Sources for SST Gene

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