SSSCA1 Gene
protein-coding GIFtS: 47
GCID: GC11P065337
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Sjogren syndrome/scleroderma autoantigen 1(Previous name: Sjogren's syndrome/scleroderma autoantigen 1 )
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Aliases
for SSSCA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sjogren Syndrome/Scleroderma Autoantigen 11 2 | | P271 | | Sjogren'S Syndrome/Scleroderma Autoantigen 11 2 | | Autoantigen P272 3 | | Centromeric Autoantigen (27kD)2 | | Sjoegren Syndrome/Scleroderma Autoantigen 12 |
Export aliases for SSSCA1 gene to outside databasesPrevious GC identifers: GC11P067853 GC11P067019 GC11P065587 GC11P065114 GC11P065116 GC11P065094 GC11P061665 |
Summaries
for SSSCA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SSSCA1:
This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren'ssyndrome. Subcellular localization has not yet been established. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SSA27_HUMAN, O60232Function: Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induceanti-centromere antibodies
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Genomic Views
for SSSCA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSSCA1 gene promoter:
Spz1 NRSF form 1 FOXO3 Nkx2-5 NRSF form 2 FOXO3b C/EBPalpha GATA-2 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSSCA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSSCA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1SSSCA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065337: view genomic region
(about GC identifiers)
Start:
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65,337,901 bp from pter |
End:
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65,341,413 bp from pter |
Size:
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3,513 bases |
Orientation:
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plus strand |
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Proteins
for SSSCA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSA27_HUMAN, O60232 (See
protein sequence)Recommended Name: Sjoegren syndrome/scleroderma autoantigen 1 Size: 199 amino acids; 21474 DaExplore the universe of human proteins at neXtProt for SSSCA1: NX_O60232
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60232
SSSCA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006387.1
ENSEMBL proteins: ENSP00000312318 ENSP00000434381 ENSP00000432938 ENSP00000431666 ENSP00000435432 ENSP00000435982
Human Recombinant Protein Products:
SSSCA1 Antibody Products:
Assay Products for SSSCA1: |
Protein
Domains /
Families
for SSSCA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSSCA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60232ProtoNet protein and cluster: O60232 |
Function
for SSSCA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SSA27_HUMAN, O60232Function: Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induceanti-centromere antibodies
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSSCA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSSCA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0042802 | identical protein binding |
IEA | -- |
SSSCA1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SSSCA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSSCA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/45 Interacting proteins for SSSCA1 (O602321, 2, 3 ENSP000003123184) via UniProtKB, MINT, STRING, and/or I2D (see all 45)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SSSCA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSSCA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSSCA1
Search CenterWatch for drugs/clinical trials and news about SSSCA1 / SSA27
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Transcripts
for SSSCA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSSCA1 gene: NM_006396.1 Unigene Cluster for SSSCA1: Sjogren syndrome/scleroderma autoantigen 1 Hs.25723 [show with all ESTs]Unigene Representative Sequence: BQ7111927 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000309328(uc001oek.3) ENST00000531405 ENST00000527920 ENST00000526877
ENST00000533115 ENST00000526433 ENST00000527413
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSSCA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSSCA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SSSCA1 (NM_006396) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSSCA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSSCA1 |
Additional cDNA sequence: AB001740.1 BC014791.2 8 DOTS entries: DT.447241 DT.447144 DT.100818514 DT.100038097 DT.100708176 DT.95275962 DT.100773817 DT.120737198 24/429 AceView cDNA sequences (see all 429): BM468381 AI337818 AA378890 CR616644 D80508 BE382395 BE501928 BP342105 BM976187 AW205414 BM055184 CB139116 BE394215 AI244226 CA941172 BQ053087 AW615007 CK819125 BU729659 BU952053 BQ773834 BE221633 BF568149 BM052909
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for SSSCA1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SSSCA1
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Expression
for SSSCA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSSCA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCGGAGGCC
About this image
See SSSCA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSSCA1
SOURCE GeneReport for Unigene cluster: Hs.25723
SABiosciences Custom PCR Arrays for SSSCA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSSCA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSSCA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSSCA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSSCA1 |
Orthologs
for SSSCA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for SSSCA1 gene from 3/15 species (see all 15) About this table
ENSEMBL Gene Tree for SSSCA1 (if available)
TreeFam Gene Tree for SSSCA1 (if available) |
Paralogs
for SSSCA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SSSCA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSSCA1 (65337901 - 65341413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SSSCA1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSSCA1 |
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Disorders
/ Diseases
for SSSCA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSSCA1 for disorders About GeneDecksing
OMIM gene information: 606044
OMIM disorders: --
8  diseases for SSSCA1: About MalaCardssjogren's syndrome scleroderma follicular lymphoma hepatocellular carcinoma
psoriasis prostate cancer prostatitis carcinoma
1 Novoseek disease relationship for SSSCA1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
15133847 (1) |
Export disorders for SSSCA1 gene to outside databases
|
Publications
for SSSCA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSSCA1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with SSSCA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies. (PubMed id 9486406)1, 2, 3 Muro Y.... Sugimoto K. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1 Al-Hakim A.K....Pelletier L. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
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External Searches for SSSCA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SSSCA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSSCA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSSCA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SSSCA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SSSCA1 gene:
Search GeneIP for patents involving SSSCA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSSCA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SSSCA1 | | OriGene shRNA RFP for SSSCA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSSCA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSSCA1 | | | OriGene Protein Over-expression Lysate for SSSCA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SSSCA1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSSCA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSSCA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SSSCA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SSSCA1 | | OriGene Custom Protein Services for SSSCA1 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSSCA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSSCA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSSCA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSSCA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSSCA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSSCA1 |
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 | | | SSSCA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SSSCA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSSCA1 |
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