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Aliases for SSSCA1 Gene

Aliases for SSSCA1 Gene

  • Sjogren Syndrome/Scleroderma Autoantigen 1 2 3
  • Sjogrens Syndrome/Scleroderma Autoantigen 1 2 3
  • Autoantigen P27 3 4
  • Sjoegren Syndrome/Scleroderma Autoantigen 1 3
  • Centromeric Autoantigen (27kD) 3
  • P27 3

External Ids for SSSCA1 Gene

Summaries for SSSCA1 Gene

Entrez Gene Summary for SSSCA1 Gene

  • This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSSCA1 Gene

SSSCA1 (Sjogren Syndrome/Scleroderma Autoantigen 1) is a Protein Coding gene. Diseases associated with SSSCA1 include follicular lymphoma and sjogrens syndrome. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for SSSCA1 Gene

  • Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSSCA1 Gene

Genomics for SSSCA1 Gene

Genomic Location for SSSCA1 Gene

Start:
65,570,430 bp from pter
End:
65,573,942 bp from pter
Size:
3,513 bases
Orientation:
Plus strand

Genomic View for SSSCA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSSCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSSCA1 Gene

Regulatory Elements for SSSCA1 Gene

Proteins for SSSCA1 Gene

  • Protein details for SSSCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60232-SSA27_HUMAN
    Recommended name:
    Sjoegren syndrome/scleroderma autoantigen 1
    Protein Accession:
    O60232
    Secondary Accessions:

    Protein attributes for SSSCA1 Gene

    Size:
    199 amino acids
    Molecular mass:
    21474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSSCA1 Gene

Proteomics data for SSSCA1 Gene at MOPED

Post-translational modifications for SSSCA1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys22, Lys64, and Lys67

Other Protein References for SSSCA1 Gene

No data available for DME Specific Peptides for SSSCA1 Gene

Domains for SSSCA1 Gene

Protein Domains for SSSCA1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SSSCA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SSSCA1 Gene

Function for SSSCA1 Gene

Molecular function for SSSCA1 Gene

UniProtKB/Swiss-Prot Function: Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies

Gene Ontology (GO) - Molecular Function for SSSCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with SSSCA1: view

miRNA for SSSCA1 Gene

miRTarBase miRNAs that target SSSCA1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SSSCA1 Gene

Localization for SSSCA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSSCA1 Gene COMPARTMENTS Subcellular localization image for SSSCA1 gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for SSSCA1 Gene

Pathways for SSSCA1 Gene

SuperPathways for SSSCA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSSCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SSSCA1: view

No data available for Pathways by source for SSSCA1 Gene

Transcripts for SSSCA1 Gene

mRNA/cDNA for SSSCA1 Gene

Unigene Clusters for SSSCA1 Gene

Sjogren syndrome/scleroderma autoantigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSSCA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for SSSCA1 Gene

GeneLoc Exon Structure for
SSSCA1
ECgene alternative splicing isoforms for
SSSCA1

Expression for SSSCA1 Gene

mRNA expression in normal human tissues for SSSCA1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSSCA1 Gene

SOURCE GeneReport for Unigene cluster for SSSCA1 Gene Hs.25723

genes like me logo Genes that share expressions with SSSCA1: view

Orthologs for SSSCA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSSCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSSCA1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSSCA1 36
  • 90.62 (n)
  • 94.97 (a)
SSSCA1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSSCA1 36
  • 90.79 (n)
  • 95.48 (a)
SSSCA1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sssca1 36
  • 84.76 (n)
  • 89.45 (a)
Sssca1 16
Sssca1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSSCA1 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSSCA1 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sssca1 36
  • 86.26 (n)
  • 89.45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sssca1 36
  • 56.76 (n)
  • 56.22 (a)
zebrafish
(Danio rerio)
Actinopterygii sssca1 36
  • 65.62 (n)
  • 68.23 (a)
sssca1 37
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y39A1A.3 37
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6817 37
  • 22 (a)
OneToOne
Species with no ortholog for SSSCA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSSCA1 Gene

ENSEMBL:
Gene Tree for SSSCA1 (if available)
TreeFam:
Gene Tree for SSSCA1 (if available)

Paralogs for SSSCA1 Gene

No data available for Paralogs for SSSCA1 Gene

Variants for SSSCA1 Gene

Sequence variations from dbSNP and Humsavar for SSSCA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1194077 -- 65,568,687(+) gaact(C/T)ctgat upstream-variant-2KB
rs7946130 -- 65,568,668(+) tgttg(A/C/G)ccagg upstream-variant-2KB
rs34586386 -- 65,568,490(+) AGAGT(-/A)CTCAC upstream-variant-2KB
rs184247566 -- 65,568,606(+) ACGGG(C/T)GCCCG upstream-variant-2KB
rs539796117 -- 65,568,610(+) GCGCC(C/T)GCCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSSCA1 Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897720 CNV Loss 21882294
dgv1176n71 CNV Loss 21882294
nsv897723 CNV Loss 21882294
nsv897730 CNV Loss 21882294
dgv1179n71 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
dgv1181n71 CNV Loss 21882294
dgv1182n71 CNV Loss 21882294
nsv897739 CNV Loss 21882294

Relevant External Links for SSSCA1 Gene

HapMap Linkage Disequilibrium report
SSSCA1

Disorders for SSSCA1 Gene

(1) University of Copenhagen DISEASES for SSSCA1 Gene

(1) Novoseek inferred disease relationships for SSSCA1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for SSSCA1

Genetic Association Database (GAD)
SSSCA1
genes like me logo Genes that share disorders with SSSCA1: view

No data available for UniProtKB/Swiss-Prot for SSSCA1 Gene

Publications for SSSCA1 Gene

  1. cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies. (PMID: 9486406) Muro Y. … Sugimoto K. (Clin. Exp. Immunol. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 49
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Subcellular localization of p27 and prostate cancer recurrence: automated digital microscopy analysis of tissue microarrays. (PMID: 21292307) Ananthanarayanan V. … Gann P.H. (Hum. Pathol. 2011) 3

Products for SSSCA1 Gene

Sources for SSSCA1 Gene

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