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Aliases for SSSCA1 Gene

Aliases for SSSCA1 Gene

  • Sjogren Syndrome/Scleroderma Autoantigen 1 2 3 5
  • Sjogrens Syndrome/Scleroderma Autoantigen 1 2 3
  • Autoantigen P27 3 4
  • Centromeric Autoantigen (27kD) 3
  • P27 3

External Ids for SSSCA1 Gene

Previous GeneCards Identifiers for SSSCA1 Gene

  • GC11P067853
  • GC11P067019
  • GC11P065587
  • GC11P065114
  • GC11P065116
  • GC11P065094
  • GC11P065337
  • GC11P061665

Summaries for SSSCA1 Gene

Entrez Gene Summary for SSSCA1 Gene

  • This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSSCA1 Gene

SSSCA1 (Sjogren Syndrome/Scleroderma Autoantigen 1) is a Protein Coding gene. Diseases associated with SSSCA1 include Sjogren's Syndrome. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for SSSCA1 Gene

  • Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSSCA1 Gene

Genomics for SSSCA1 Gene

Regulatory Elements for SSSCA1 Gene

Enhancers for SSSCA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSSCA1 on UCSC Golden Path with GeneCards custom track

Promoters for SSSCA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSSCA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSSCA1 Gene

65,570,430 bp from pter
65,573,942 bp from pter
3,513 bases
Plus strand

Genomic View for SSSCA1 Gene

Genes around SSSCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSSCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSSCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSSCA1 Gene

Proteins for SSSCA1 Gene

  • Protein details for SSSCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sjoegren syndrome/scleroderma autoantigen 1
    Protein Accession:

    Protein attributes for SSSCA1 Gene

    199 amino acids
    Molecular mass:
    21474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSSCA1 Gene

Proteomics data for SSSCA1 Gene at MOPED

Post-translational modifications for SSSCA1 Gene

  • Ubiquitination at Lys 64 and Lys 67
  • Modification sites at PhosphoSitePlus

Other Protein References for SSSCA1 Gene

No data available for DME Specific Peptides for SSSCA1 Gene

Domains & Families for SSSCA1 Gene

Protein Domains for SSSCA1 Gene


Suggested Antigen Peptide Sequences for SSSCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSSCA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SSSCA1 Gene

Function for SSSCA1 Gene

Molecular function for SSSCA1 Gene

UniProtKB/Swiss-Prot Function:
Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.
genes like me logo Genes that share phenotypes with SSSCA1: view

Animal Model Products

miRNA for SSSCA1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSSCA1 Gene

Localization for SSSCA1 Gene

Subcellular locations from

Jensen Localization Image for SSSCA1 Gene COMPARTMENTS Subcellular localization image for SSSCA1 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SSSCA1 Gene

Pathways & Interactions for SSSCA1 Gene

SuperPathways for SSSCA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSSCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SSSCA1: view

No data available for Pathways by source and SIGNOR curated interactions for SSSCA1 Gene

Drugs & Compounds for SSSCA1 Gene

No Compound Related Data Available

Transcripts for SSSCA1 Gene

Unigene Clusters for SSSCA1 Gene

Sjogren syndrome/scleroderma autoantigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSSCA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP4: -

Relevant External Links for SSSCA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSSCA1 Gene

mRNA expression in normal human tissues for SSSCA1 Gene

Protein differential expression in normal tissues from HIPED for SSSCA1 Gene

This gene is overexpressed in Heart (18.0) and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSSCA1 Gene

SOURCE GeneReport for Unigene cluster for SSSCA1 Gene Hs.25723

genes like me logo Genes that share expression patterns with SSSCA1: view

Protein tissue co-expression partners for SSSCA1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSSCA1 Gene

Orthologs for SSSCA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSSCA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SSSCA1 35
  • 90.62 (n)
  • 94.97 (a)
  • 95 (a)
(Canis familiaris)
Mammalia SSSCA1 35
  • 90.79 (n)
  • 95.48 (a)
  • 92 (a)
(Mus musculus)
Mammalia Sssca1 35
  • 84.76 (n)
  • 89.45 (a)
Sssca1 16
Sssca1 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Sssca1 35
  • 86.26 (n)
  • 89.45 (a)
(Monodelphis domestica)
Mammalia SSSCA1 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia SSSCA1 36
  • 52 (a)
(Pan troglodytes)
Mammalia SSSCA1 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia sssca1 35
  • 56.76 (n)
  • 56.22 (a)
(Danio rerio)
Actinopterygii sssca1 35
  • 65.62 (n)
  • 68.23 (a)
sssca1 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea Y39A1A.3 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6817 36
  • 22 (a)
Species with no ortholog for SSSCA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSSCA1 Gene

Gene Tree for SSSCA1 (if available)
Gene Tree for SSSCA1 (if available)

Paralogs for SSSCA1 Gene

No data available for Paralogs for SSSCA1 Gene

Variants for SSSCA1 Gene

Sequence variations from dbSNP and Humsavar for SSSCA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_051383 -
rs1194077 -- 65,568,687(+) gaact(C/T)ctgat upstream-variant-2KB
rs1213059 -- 65,568,462(+) atgcc(A/C)aatgg upstream-variant-2KB
rs7946130 -- 65,568,668(+) tgttg(A/C/G)ccagg upstream-variant-2KB
rs113451105 -- 65,568,469(+) ATGGC(-/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSSCA1 Gene

Variant ID Type Subtype PubMed ID
dgv1175n71 CNV Loss 21882294
nsv897718 CNV Loss 21882294
nsv897720 CNV Loss 21882294
dgv1176n71 CNV Loss 21882294
nsv897723 CNV Loss 21882294
nsv897730 CNV Loss 21882294
dgv1179n71 CNV Loss 21882294
dgv1180n71 CNV Loss 21882294
nsv897736 CNV Loss 21882294
dgv1181n71 CNV Loss 21882294
dgv1182n71 CNV Loss 21882294
nsv897739 CNV Loss 21882294

Variation tolerance for SSSCA1 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SSSCA1 Gene

Disorders for SSSCA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSSCA1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SSSCA1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SSSCA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSSCA1 Gene

Publications for SSSCA1 Gene

  1. cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies. (PMID: 9486406) Muro Y. … Sugimoto K. (Clin. Exp. Immunol. 1998) 2 3 4 67
  2. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for SSSCA1 Gene

Sources for SSSCA1 Gene