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Aliases for SSSCA1 Gene

Aliases for SSSCA1 Gene

  • Sjogren Syndrome/Scleroderma Autoantigen 1 2 3 5
  • Sjogrens Syndrome/Scleroderma Autoantigen 1 2 3
  • Autoantigen P27 3 4
  • Sjoegren Syndrome/Scleroderma Autoantigen 1 3
  • Centromeric Autoantigen (27kD) 3
  • P27 3

External Ids for SSSCA1 Gene

Previous GeneCards Identifiers for SSSCA1 Gene

  • GC11P067853
  • GC11P067019
  • GC11P065587
  • GC11P065114
  • GC11P065116
  • GC11P065094
  • GC11P065337
  • GC11P061665

Summaries for SSSCA1 Gene

Entrez Gene Summary for SSSCA1 Gene

  • This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSSCA1 Gene

SSSCA1 (Sjogren Syndrome/Scleroderma Autoantigen 1) is a Protein Coding gene. Diseases associated with SSSCA1 include Sjogren's Syndrome. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for SSSCA1 Gene

  • Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

Additional gene information for SSSCA1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSSCA1 Gene

Genomics for SSSCA1 Gene

Regulatory Elements for SSSCA1 Gene

Enhancers for SSSCA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 39.7 -80.3 -80347 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 38.6 -146.2 -146249 18 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
GH11H065886 1.9 FANTOM5 ENCODE dbSUPER 22.5 +325.0 325029 18 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SNX32 RBM14 ENSG00000258297 ENSG00000254461 MUS81 SART1 CTSW KAT5 SF3B2 EIF1AD
GH11H065567 1.7 FANTOM5 ENCODE dbSUPER 21.4 +3.2 3245 11 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 PCNX3 SF1 POLA2 LOC105369352 EIF1AD SF3B2 EHBP1L1 ENSG00000254461 KAT5 SART1
GH11H065636 1.6 FANTOM5 ENCODE dbSUPER 22.3 +70.3 70253 8 HDGF PKNOX1 ZFP64 ARID4B SIN3A YBX1 ZNF143 ZNF207 PAF1 SP3 SIPA1 SSSCA1 KCNK7 RNASEH2C MAP3K11 LOC105369352 EHBP1L1 ZFPL1 TIGD3 EIF1AD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSSCA1 on UCSC Golden Path with GeneCards custom track

Promoters for SSSCA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000264462 -130 1801 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for SSSCA1 Gene

Chromosome:
11
Start:
65,570,430 bp from pter
End:
65,573,942 bp from pter
Size:
3,513 bases
Orientation:
Plus strand

Genomic View for SSSCA1 Gene

Genes around SSSCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSSCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSSCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSSCA1 Gene

Proteins for SSSCA1 Gene

  • Protein details for SSSCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60232-SSA27_HUMAN
    Recommended name:
    Sjoegren syndrome/scleroderma autoantigen 1
    Protein Accession:
    O60232

    Protein attributes for SSSCA1 Gene

    Size:
    199 amino acids
    Molecular mass:
    21474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSSCA1 Gene

Post-translational modifications for SSSCA1 Gene

  • Ubiquitination at posLast=6464 and Lys67
  • Modification sites at PhosphoSitePlus

Other Protein References for SSSCA1 Gene

No data available for DME Specific Peptides for SSSCA1 Gene

Domains & Families for SSSCA1 Gene

Gene Families for SSSCA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SSSCA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSSCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSSCA1: view

No data available for UniProtKB/Swiss-Prot for SSSCA1 Gene

Function for SSSCA1 Gene

Molecular function for SSSCA1 Gene

UniProtKB/Swiss-Prot Function:
Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

Phenotypes From GWAS Catalog for SSSCA1 Gene

Gene Ontology (GO) - Molecular Function for SSSCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with SSSCA1: view
genes like me logo Genes that share phenotypes with SSSCA1: view

Animal Model Products

CRISPR Products

miRNA for SSSCA1 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SSSCA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSSCA1 Gene

Localization for SSSCA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSSCA1 gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SSSCA1 Gene

Pathways & Interactions for SSSCA1 Gene

SuperPathways for SSSCA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSSCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS 9486406
GO:0007049 cell cycle IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SSSCA1: view

No data available for Pathways by source and SIGNOR curated interactions for SSSCA1 Gene

Drugs & Compounds for SSSCA1 Gene

No Compound Related Data Available

Transcripts for SSSCA1 Gene

Unigene Clusters for SSSCA1 Gene

Sjogren syndrome/scleroderma autoantigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SSSCA1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SSSCA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for SSSCA1 Gene

GeneLoc Exon Structure for
SSSCA1
ECgene alternative splicing isoforms for
SSSCA1

Expression for SSSCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSSCA1 Gene

Protein differential expression in normal tissues from HIPED for SSSCA1 Gene

This gene is overexpressed in Heart (18.0) and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSSCA1 Gene



Protein tissue co-expression partners for SSSCA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSSCA1 Gene:

SSSCA1

SOURCE GeneReport for Unigene cluster for SSSCA1 Gene:

Hs.25723

Evidence on tissue expression from TISSUES for SSSCA1 Gene

  • Muscle(2.5)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with SSSCA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSSCA1 Gene

Orthologs for SSSCA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSSCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSSCA1 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSSCA1 33 34
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia SSSCA1 33 34
  • 90.62 (n)
rat
(Rattus norvegicus)
Mammalia Sssca1 33
  • 86.26 (n)
mouse
(Mus musculus)
Mammalia Sssca1 33 16 34
  • 84.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SSSCA1 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSSCA1 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sssca1 33
  • 56.76 (n)
zebrafish
(Danio rerio)
Actinopterygii sssca1 33 34
  • 65.62 (n)
worm
(Caenorhabditis elegans)
Secernentea Y39A1A.3 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6817 34
  • 22 (a)
OneToOne
Species where no ortholog for SSSCA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSSCA1 Gene

ENSEMBL:
Gene Tree for SSSCA1 (if available)
TreeFam:
Gene Tree for SSSCA1 (if available)

Paralogs for SSSCA1 Gene

No data available for Paralogs for SSSCA1 Gene

Variants for SSSCA1 Gene

Sequence variations from dbSNP and Humsavar for SSSCA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000078512 -- 65,569,791(+) AATGC(C/G)CGTGC nc-transcript-variant, upstream-variant-2KB
rs1001342869 -- 65,570,438(+) AGCGG(A/C)GGGCG upstream-variant-2KB
rs1001625621 -- 65,570,229(+) CCGGA(G/T)GAGAG nc-transcript-variant, upstream-variant-2KB
rs1003090160 -- 65,569,657(+) GGTCC(A/C)TGTTC nc-transcript-variant, upstream-variant-2KB
rs1003738204 -- 65,572,311(+) GGCGG(C/G)GCGCG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSSCA1 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
nsv951018 CNV deletion 24416366

Variation tolerance for SSSCA1 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSSCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSSCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSSCA1 Gene

Disorders for SSSCA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSSCA1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SSSCA1

Genetic Association Database (GAD)
SSSCA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSSCA1
genes like me logo Genes that share disorders with SSSCA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSSCA1 Gene

Publications for SSSCA1 Gene

  1. cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies. (PMID: 9486406) Muro Y … Sugimoto K (Clinical and experimental immunology 1998) 2 3 4 60
  2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60

Products for SSSCA1 Gene

Sources for SSSCA1 Gene

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