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Aliases for SSSCA1 Gene

Aliases for SSSCA1 Gene

  • Sjogren Syndrome/Scleroderma Autoantigen 1 2 3 5
  • Sjogrens Syndrome/Scleroderma Autoantigen 1 2 3
  • Autoantigen P27 3 4
  • Sjoegren Syndrome/Scleroderma Autoantigen 1 3
  • Centromeric Autoantigen (27kD) 3
  • P27 3

External Ids for SSSCA1 Gene

Previous GeneCards Identifiers for SSSCA1 Gene

  • GC11P067853
  • GC11P067019
  • GC11P065587
  • GC11P065114
  • GC11P065116
  • GC11P065094
  • GC11P065337
  • GC11P061665

Summaries for SSSCA1 Gene

Entrez Gene Summary for SSSCA1 Gene

  • This antigen is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjogren's syndrome. Subcellular localization has not yet been established. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSSCA1 Gene

SSSCA1 (Sjogren Syndrome/Scleroderma Autoantigen 1) is a Protein Coding gene. Diseases associated with SSSCA1 include Sjogren's Syndrome. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for SSSCA1 Gene

  • Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSSCA1 Gene

Genomics for SSSCA1 Gene

Regulatory Elements for SSSCA1 Gene

Enhancers for SSSCA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065470 2.1 VISTA FANTOM5 Ensembl ENCODE 28.8 -80.3 -80347 40.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 LOC105369353 LOC105369352 KAT5 SSSCA1-AS1 NEAT1 ZFPL1 EIF1AD EHBP1L1 MRPL11 POLA2
GH11F065650 1.4 FANTOM5 Ensembl ENCODE 19.9 +82.9 82933 6.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 LOC105369352 RNASEH2C ZFPL1 KAT5 RBM14 MRPL11 LOC105369353 EIF1AD MUS81 MAP3K11
GH11F065414 1.4 FANTOM5 ENCODE 19.8 -146.2 -146249 18.8 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEAT1 ZFPL1 KAT5 EIF1AD LOC105369352 POLA2 MUS81 PCNX3 FRMD8 ENSG00000255320
GH11F065886 0.8 FANTOM5 ENCODE 12.4 +325.0 325029 18.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SNX32 CTSW MRPL11 EIF1AD NEAT1 MUS81 ENSG00000258297 KAT5 FAU POLA2
GH11F065365 1.2 Ensembl ENCODE 11.7 -203.5 -203463 2.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CD248 SSSCA1 NEAT1 ZFPL1 FAU LOC105369352 MRPL49 LOC728975 SLC25A45 ENSG00000255478
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SSSCA1 on UCSC Golden Path with GeneCards custom track

Promoters for SSSCA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563859 -130 1801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for SSSCA1 Gene

Chromosome:
11
Start:
65,570,430 bp from pter
End:
65,573,942 bp from pter
Size:
3,513 bases
Orientation:
Plus strand

Genomic View for SSSCA1 Gene

Genes around SSSCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSSCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSSCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSSCA1 Gene

Proteins for SSSCA1 Gene

  • Protein details for SSSCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60232-SSA27_HUMAN
    Recommended name:
    Sjoegren syndrome/scleroderma autoantigen 1
    Protein Accession:
    O60232

    Protein attributes for SSSCA1 Gene

    Size:
    199 amino acids
    Molecular mass:
    21474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSSCA1 Gene

Post-translational modifications for SSSCA1 Gene

  • Ubiquitination at Lys 64 and Lys 67
  • Modification sites at PhosphoSitePlus

Other Protein References for SSSCA1 Gene

No data available for DME Specific Peptides for SSSCA1 Gene

Domains & Families for SSSCA1 Gene

Protein Domains for SSSCA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSSCA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSSCA1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SSSCA1 Gene

Function for SSSCA1 Gene

Molecular function for SSSCA1 Gene

UniProtKB/Swiss-Prot Function:
Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.

Gene Ontology (GO) - Molecular Function for SSSCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with SSSCA1: view
genes like me logo Genes that share phenotypes with SSSCA1: view

Animal Model Products

miRNA for SSSCA1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSSCA1 Gene

Localization for SSSCA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSSCA1 Gene COMPARTMENTS Subcellular localization image for SSSCA1 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SSSCA1 Gene

Pathways & Interactions for SSSCA1 Gene

SuperPathways for SSSCA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSSCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with SSSCA1: view

No data available for Pathways by source and SIGNOR curated interactions for SSSCA1 Gene

Transcripts for SSSCA1 Gene

Unigene Clusters for SSSCA1 Gene

Sjogren syndrome/scleroderma autoantigen 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSSCA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d
SP1:
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for SSSCA1 Gene

GeneLoc Exon Structure for
SSSCA1
ECgene alternative splicing isoforms for
SSSCA1

Expression for SSSCA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSSCA1 Gene

Protein differential expression in normal tissues from HIPED for SSSCA1 Gene

This gene is overexpressed in Heart (18.0) and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSSCA1 Gene



Protein tissue co-expression partners for SSSCA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSSCA1 Gene:

SSSCA1

SOURCE GeneReport for Unigene cluster for SSSCA1 Gene:

Hs.25723
genes like me logo Genes that share expression patterns with SSSCA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSSCA1 Gene

Orthologs for SSSCA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSSCA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSSCA1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSSCA1 34 35
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia SSSCA1 34 35
  • 90.62 (n)
rat
(Rattus norvegicus)
Mammalia Sssca1 34
  • 86.26 (n)
mouse
(Mus musculus)
Mammalia Sssca1 34 16 35
  • 84.76 (n)
oppossum
(Monodelphis domestica)
Mammalia SSSCA1 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSSCA1 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sssca1 34
  • 56.76 (n)
zebrafish
(Danio rerio)
Actinopterygii sssca1 34 35
  • 65.62 (n)
worm
(Caenorhabditis elegans)
Secernentea Y39A1A.3 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6817 35
  • 22 (a)
OneToOne
Species where no ortholog for SSSCA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSSCA1 Gene

ENSEMBL:
Gene Tree for SSSCA1 (if available)
TreeFam:
Gene Tree for SSSCA1 (if available)

Paralogs for SSSCA1 Gene

No data available for Paralogs for SSSCA1 Gene

Variants for SSSCA1 Gene

Sequence variations from dbSNP and Humsavar for SSSCA1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1046376 -- 65,570,695(+) CGGCT(A/C)ATGGG upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs111357827 -- 65,570,971(+) TCCCG(C/G)TAAGA upstream-variant-2KB, splice-donor-variant
rs11227227 -- 65,571,907(+) AGCTT(A/G)TTTCT downstream-variant-500B, upstream-variant-2KB
rs112403982 -- 65,570,602(+) TCCCC(A/G/T)GAAGT upstream-variant-2KB, splice-acceptor-variant, utr-variant-5-prime
rs112731049 -- 65,569,814(+) TATTC(A/G)GTCTG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSSCA1 Gene

Variant ID Type Subtype PubMed ID
dgv1969n54 CNV loss 21841781
nsv951018 CNV deletion 24416366

Variation tolerance for SSSCA1 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSSCA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSSCA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSSCA1 Gene

Disorders for SSSCA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSSCA1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SSSCA1

Genetic Association Database (GAD)
SSSCA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSSCA1
genes like me logo Genes that share disorders with SSSCA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSSCA1 Gene

Publications for SSSCA1 Gene

  1. cDNA cloning of a novel autoantigen targeted by a minor subset of anti-centromere antibodies. (PMID: 9486406) Muro Y. … Sugimoto K. (Clin. Exp. Immunol. 1998) 2 3 4 64
  2. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SSSCA1 Gene

Sources for SSSCA1 Gene

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