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SSRP1 Gene

protein-coding   GIFtS: 60
GCID: GC11M057093

Structure Specific Recognition Protein 1

  Search for SSRP1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Structure Specific Recognition Protein 11 2     FACTp802 3
Facilitates Chromatin Remodeling 80 KDa Subunit1 2     T1602 3
Chromatin-Specific Transcription Elongation Factor 80 KDa Subunit2 3     FACT 80 KDa Subunit2 3
Facilitates Chromatin Transcription Complex 80 KDa Subunit2 3     hSSRP12 3
Facilitates Chromatin Transcription Complex Subunit SSRP12 3     FACT2 5
Recombination Signal Sequence Recognition Protein 12 3     Cisplatin-DNA SSRP2
Structure-Specific Recognition Protein 12 3     FACT Complex Subunit SSRP12
FACT802 3     High Mobility Group Box2

External Ids:    HGNC: 113271   Entrez Gene: 67492   Ensembl: ENSG000001491367   OMIM: 6043285   UniProtKB: Q089453   

Export aliases for SSRP1 gene to outside databases

Previous GC identifers: GC11M059487 GC11M058606 GC11M057344 GC11M056868 GC11M056850 GC11M053442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSRP1 Gene:
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin
transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome
disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer
mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the
structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the
transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but
its full-length nature is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for SSRP1 Gene:
SSRP1 (structure specific recognition protein 1) is a protein-coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TOX.

UniProtKB/Swiss-Prot: SSRP1_HUMAN, Q08945
Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication
and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both
destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and
transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently
promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is
probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase
II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent
cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also
acts as a transcriptional coactivator for p63/TP63

Gene Wiki entry for SSRP1 (Structure specific recognition protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSRP1 gene promoter:
         STAT5B   Pax-5   Lmo2   POU3F2   GATA-1   PPAR-gamma1   NRF-2   HFH-1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSRP1 promoter sequence
   Search Chromatin IP Primers for SSRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

SSRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSRP1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057093:  view genomic region     (about GC identifiers)

Start:
57,093,459 bp from pter      End:
57,103,351 bp from pter
Size:
9,893 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SSRP1_HUMAN, Q08945 (See protein sequence)
Recommended Name: FACT complex subunit SSRP1  
Size: 709 amino acids; 81075 Da
Subunit: Interacts with MYOG (via C-terminus region) (By similarity). Component of the FACT complex, a stable
heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complex which forms following UV
irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Binds to histone H3-H4 tetramers, but not
to intact nucleosomes. Interacts with isoform gamma of TP63. Interacts with FYTTD1/UIF, SRF and NEK9
Miscellaneous: Autoantibodies against SSRP1 are present in sera from patients with systemic lupus erythematosus,
but not other rheumatic diseases
Sequence caution: Sequence=AAH91486.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
1 PDB 3D structure from and Proteopedia for SSRP1:
4IFS (3D)    
Secondary accessions: Q5BJG8

Explore the universe of human proteins at neXtProt for SSRP1: NX_Q08945

Explore proteomics data for SSRP1 at MOPED

Post-translational modifications: 

  • Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity1
  • Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal
    ubiquitinated part of the cleaved protein1
  • Sumoylated1
  • Ubiquitination2 at Lys15, Lys39, Lys63, Lys84, Lys90, Lys105, Lys228, Lys233, Lys304, Lys319,
                                 Lys325, Lys566
  • Modification sites at PhosphoSitePlus

  • See SSRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003137.1  
    ENSEMBL proteins: 
     ENSP00000278412   ENSP00000431154   ENSP00000434546  
    Reactome Protein details: Q08945

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    Novus Biologicals SSRP1 Proteins
    Novus Biologicals SSRP1 Lysate
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    Search eBioscience for ELISAs for SSRP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR013719 DUF1747
     IPR011993 PH_like_dom
     IPR000969 SSrcognition
     IPR024954 SSRP1_dom

    Graphical View of Domain Structure for InterPro Entry Q08945

    ProtoNet protein and cluster: Q08945

    1 Blocks protein domain: IPB000969 Structure-specific recognition protein signature

    UniProtKB/Swiss-Prot: SSRP1_HUMAN, Q08945
    Domain: The HMG box DNA-binding domain mediates DNA-binding. It has both affinity and specificity for DNA damaged
    globally with cisplatin
    Similarity: Belongs to the SSRP1 family
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with SSRP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSRP1_HUMAN, Q08945
    Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT
    complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication
    and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both
    destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and
    transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently
    promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is
    probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase
    II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent
    cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also
    acts as a transcriptional coactivator for p63/TP63

         Genatlas biochemistry entry for SSRP1:
    structure specific recognition protein 1,essential for transcription,binding specifically to DNA modified by the
    anticancer agent cysplatin,81kDa,80kDa subunit of the chromatin specific elongation factor FACT,interacting with
    nucleosomes and histone H2A/H2B dimers,indicating that it may promote nucleosome disruption upon transcription
    (see FACT140)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI16902406
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SSRP1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ssrp1):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with SSRP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ssrp1tm1Rul for SSRP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSRP1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSRP1

    miRNA
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    miRTarBase miRNAs that target SSRP1:
    hsa-mir-3200-3p (MIRT052826), hsa-mir-193b-3p (MIRT041569), hsa-mir-20a-5p (MIRT050489), hsa-mir-25-3p (MIRT050286), hsa-mir-23a-3p (MIRT050408), hsa-mir-1301-3p (MIRT036046), hsa-mir-92b-3p (MIRT040724), hsa-mir-23b-3p (MIRT046282)

    Block miRNA regulation of human, mouse, rat SSRP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SSRP1:
    hsa-miR-223 hsa-miR-708 hsa-miR-204 hsa-miR-28-5p hsa-miR-3139 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidSSRP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SSRP1
    Predesigned siRNA for gene silencing in human, mouse, rat SSRP1

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSRP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSRP1_HUMAN, Q08945: Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on
    chromatin. Recruited to actively transcribed loci
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome IEA--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with SSRP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSRP1 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    Tat-mediated elongation of the HIV-1 transcript0.77
    Pausing and recovery of HIV elongation0.73
    HIV Transcription Elongation0.77
    HIV elongation arrest and recovery0.73
    Formation of HIV-1 elongation complex containing HIV-1 Tat0.77
    Pausing and recovery of Tat-mediated HIV elongation0.72
    RNA Polymerase II Transcription Elongation0.75
    Tat-mediated HIV elongation arrest and recovery0.72
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3Gene Expression
    Gene Expression0.40
    4Disease
    Disease
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with SSRP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SSRP1
        Chromatin Regulation / Acetylation

    Selected Reactome Pathways for SSRP1 (see all 10)
        Pausing and recovery of Tat-mediated HIV elongation
    Formation of RNA Pol II elongation complex
    Tat-mediated HIV elongation arrest and recovery
    Tat-mediated elongation of the HIV-1 transcript
    Pausing and recovery of HIV elongation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSRP1
    Interactions:

        GeneGlobe Interaction Network for SSRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSRP1 (Q089451, 2, 3 ENSP000002784124) via UniProtKB, MINT, STRING, and/or I2D (see all 550)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCM4P339911, 2, 3, ENSP000002621054EBI-353771,EBI-374938 MINT-2984401 MINT-6542674 MINT-2984219 MINT-2984419 MINT-2984494 MINT-8173832 MINT-2984477 MINT-8089790 I2D: score=4 STRING: ENSP00000262105
    HIST1H4AP628053, ENSP000003529804I2D: score=7 STRING: ENSP00000352980
    HIST1H4HP628053, ENSP000002893524I2D: score=7 STRING: ENSP00000289352
    HIST1H4FP628053, ENSP000003669744I2D: score=7 STRING: ENSP00000366974
    HIST1H4BP628053I2D: score=7 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with SSRP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSRP1

    2 Novoseek inferred chemical compound relationships for SSRP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cisplatin 32.5 31 11344167 (7), 19372586 (5), 1372440 (2), 8479916 (1)
    serine 3.95 1 15034300 (1)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSRP1 gene: 
    NM_003146.2  

    Unigene Cluster for SSRP1:

    Structure specific recognition protein 1
    Hs.523680  [show with all ESTs]
    Unigene Representative Sequence: M86737
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278412(uc010rjq.1 uc001njt.3) ENST00000293880 ENST00000526696
    ENST00000529002
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSSRP1 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SSRP1
      QuantiFast Probe-based Assays in human, mouse, rat SSRP1

    Additional mRNA sequence: 

    BC005116.1 BC091486.1 M86737.1 

    17 DOTS entries:

    DT.101971459  DT.218848  DT.95351445  DT.120751498  DT.97855369  DT.120751476  DT.120751487  DT.40116821 
    DT.100816084  DT.92001705  DT.95270817  DT.95270819  DT.100801846  DT.100816666  DT.100868799  DT.120751500 
    DT.97864763 

    Selected AceView cDNA sequences (see all 560):

    CK905192 BQ888541 BQ774082 BC005116 CR610078 BM706921 AW138326 AI424673 
    CB217074 AI298177 N47701 CA441639 BU902074 BQ889719 BQ641427 BQ877677 
    AI832834 AW516350 BG028468 BM463426 AA155636 BU733376 BM800166 BU902568 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSRP1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:        -     -                                                                                               -                                             
    SP2:                                                                                                              -                                             
    SP3:                    -                                                                                                                                       
    SP4:        -     -     -                                                                                                                                       
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for SSRP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SSRP1 Expression
    About this image


    SSRP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Brain (Nervous System)
             Cerebellum
    SSRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSRP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523680
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SSRP1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssrp11 , 5 structure specific recognition protein 11, 5 89.03(n)1
    97.03(a)1
      2 (49.45 cM)5
    208331  NM_001136081.21  NP_001129553.11 
     850372345 
    chicken
    (Gallus gallus)
    Aves SSRP11 structure specific recognition protein 1 81.74(n)
    90.13(a)
      396509  NM_001005796.2  NP_001005796.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSRP16
    structure specific recognition protein 1
    89(a)
    1 ↔ 1
    1(92125567-92137425)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.3362 Xenopus laevis mRNA for DUF87, complete cds 78.03(n)    AB004793.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.206902 Danio rerio cDNA clone MGC66086 IMAGE6797288, complete more 79.38(n)    BC056311.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ssrp1 , 3 single-stranded DNA binding3
    Structure specific recognition protein1
    56(a)3
    56.63(n)1
    51.44(a)1
      60A23
    377671  NM_079106.21  NP_523830.21 
    worm
    (Caenorhabditis elegans)
    Secernentea hmg-41 , 3 hmg-41 40(a)
    (best of 2)3
    50.44(n)1
    43.05(a)1
      III(7451023-7453337)3
    1760521  NM_066232.51  NP_498633.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POB3(YML069W)4 Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), more   --   13(135500-137158) 854933  NP_013642.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HMG1 HMG 47.51(n)
    36.29(a)
      822505  NM_113794.3  NP_189515.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01849001 Os01g0184900 48.12(n)
    35.1(a)
      4325652  NM_001048772.1  NP_001042237.1 


    ENSEMBL Gene Tree for SSRP1 (if available)
    TreeFam Gene Tree for SSRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSRP1 gene
    TOX2  TOX42  TOX32  TOX22  
    1 SIMAP similar gene for SSRP1 using alignment to 4 protein entries:     SSRP1_HUMAN (see all proteins):
    HMGB2

    Find genes that share paralogs with SSRP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSRP1 (see all 250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs602105711,2
    --57094479(+) TCACTC/GTGAAC 1 -- int10--------
    rs1472307541,2
    C--57094490(+) GTAAAC/TAGCTG 1 -- int10--------
    rs116022651,2
    C,F,A,H--57094506(+) GCCTGG/AAGGGC 1 -- int19Minor allele frequency- A:0.08NA CSA WA EA 370
    rs116022661,2
    C,F,H--57094509(+) TGGAGG/AGCACC 1 -- int15Minor allele frequency- A:0.07NA EA 246
    rs49388621,2
    C,F,A,H--57094592(+) CTTGAC/TATTTC 1 -- int121Minor allele frequency- T:0.04NS EA NA WA CSA 1557
    rs1814222431,2
    --57094749(+) CTTGGA/GCAATG 1 -- int10--------
    rs572312321,2
    C--57094804(+) ATCTC-/TGCTGT 1 -- int10--------
    rs341675791,2
    C--57094825(+) CAATG-/CCTCAA 1 -- int10--------
    rs127962921,2
    --57094827(+) AATGCT/CCAACT 1 -- int12Minor allele frequency- C:0.25NA 4
    rs3680017361,2
    F,H--57094828(+) ATGCT-/CAACTT 1 -- int15Minor allele frequency- T:0.01NS EA NA 418

    HapMap Linkage Disequilibrium report for SSRP1 (57093459 - 57103351 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SSRP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SSRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604328    OMIM disorders: --


    Find genes that share disorders with SSRP1           About GenesLikeMe


    Export disorders for SSRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSRP1 gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with SSRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. (PubMed id 1372440)1, 2, 3, 9 Bruhn S.L.... Lippard S.J. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. (PubMed id 11344167)1, 2, 9 Yarnell A.T.... Lippard S.J. (J. Biol. Chem. 2001)
    3. CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. (PubMed id 15659405)1, 2, 9 Li Y.... Lu H. (J. Biol. Chem. 2005)
    4. SSRP1 functions as a co-activator of the transcriptional activator p63. (PubMed id 12374749)1, 2, 9 Zeng S.X.... Lu H. (EMBO J. 2002)
    5. Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis. (PubMed id 16498457)1, 2, 9 Landais I.... Lu H. (Cell Death Differ. 2006)
    6. The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. (PubMed id 9566881)1, 2, 9 Dyer M.A.... Baron M.H. (Mol. Cell. Biol. 1998)
    7. High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases. (PubMed id 11824977)1, 2, 9 Santoro P....Gariglio M. (J. Rheumatol. 2002)
    8. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PubMed id 11239457)1, 2, 9 Keller D.M.... Lu H. (Mol. Cell 2001)
    9. p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. (PubMed id 12393879)1, 2, 9 Keller D.M. and Lu H. (J. Biol. Chem. 2002)
    10. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PubMed id 10421373)1, 2, 9 Orphanides G.... Reinberg D. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6749 HGNC: 11327 AceView: SSRP1 Ensembl:ENSG00000149136 euGenes: HUgn6749
    ECgene: SSRP1 H-InvDB: SSRP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSRP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSRP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSRP1 gene:
    Search GeneIP for patents involving SSRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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