SSRP1 Gene
protein-coding GIFtS: 57
GCID: GC11M057093
|
|
structure specific recognition protein 1
| |
Aliases
for SSRP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Structure Specific Recognition Protein 11 2 | | T1602 3 | | FACT801 2 3 | | FACT 80 KDa Subunit2 3 | | Chromatin-Specific Transcription Elongation Factor 80 KDa Subunit2 3 | | HSSRP11 | | Facilitates Chromatin Transcription Complex 80 KDa Subunit2 3 | | FACT2 5 | | Facilitates Chromatin Transcription Complex Subunit SSRP12 3 | | Cisplatin-DNA SSRP2 | | Recombination Signal Sequence Recognition Protein 12 3 | | Facilitates Chromatin Remodeling 80 KDa Subunit2 | | Structure-Specific Recognition Protein 12 3 | | FACT Complex Subunit SSRP12 | | FACTp802 3 | | High Mobility Group Box2 |
Export aliases for SSRP1 gene to outside databasesPrevious GC identifers: GC11M059487 GC11M058606 GC11M057344 GC11M056868 GC11M056850 GC11M053442 |
Summaries
for SSRP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SSRP1:
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatintranscriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosomedisassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism ofcisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structurerecognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptionalactivator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length natureis not known. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SSRP1_HUMAN, Q08945Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACTcomplex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication andDNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes andrestores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting thedissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of thenucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylationof 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNAand at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death byblocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63
Gene Wiki entry for SSRP1 (Structure specific recognition protein 1)
|
Genomic Views
for SSRP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSRP1 gene promoter:
STAT5B Pax-5 Lmo2 POU3F2 GATA-1 PPAR-gamma1 NRF-2 HFH-1 PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSRP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSRP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12SSRP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M057093: view genomic region
(about GC identifiers)
Start:
|
57,093,459 bp from pter |
End:
|
57,103,351 bp from pter |
Size:
|
9,893 bases |
Orientation:
|
minus strand |
|
Proteins
for SSRP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSRP1_HUMAN, Q08945 (See
protein sequence)Recommended Name: FACT complex subunit SSRP1 Size: 709 amino acids; 81075 Da
Subunit: Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Binds tohistone H3-H4 tetramers, but not to intact nucleosomes. Interacts with isoform gamma of TP63. Interacts withFYTTD1/UIF, SRF and NEK9
Subcellular location: Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin.Recruited to actively transcribed loci
Miscellaneous: Autoantibodies against SSRP1 are present in sera from patients with systemic lupus erythematosus, butnot other rheumatic diseases
Sequence caution: Sequence=AAH91486.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
Secondary accessions: Q5BJG8Explore the universe of human proteins at neXtProt for SSRP1: NX_Q08945
Post-translational modifications:
Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity1
Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinatedpart of the cleaved protein1
Sumoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08945
SSRP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003137.1
ENSEMBL proteins: ENSP00000278412 ENSP00000431154 ENSP00000434546 Reactome Protein details: Q08945
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SSRP1 for ontologies About GeneDecksing
SSRP1 Antibody Products:
Assay Products for SSRP1: |
Protein
Domains /
Families
for SSRP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSRP1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08945ProtoNet protein and cluster: Q08945 1 Blocks protein family: IPB000969 Structure-specific recognition protein signature
UniProtKB/Swiss-Prot: SSRP1_HUMAN, Q08945Domain: The HMG box DNA-binding domain mediates DNA-binding. It has both affinity and specificity for DNA damagedglobally with cisplatinSimilarity: Belongs to the SSRP1 familySimilarity: Contains 1 HMG box DNA-binding domain |
Function
for SSRP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SSRP1_HUMAN, Q08945Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACTcomplex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication andDNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes andrestores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting thedissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of thenucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylationof 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNAand at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death byblocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63 Genatlas biochemistry entry for SSRP1:structure specific recognition protein 1,essential for transcription,binding specifically to DNA modified by theanticancer agent cysplatin,81kDa,80kDa subunit of the chromatin specific elongation factor FACT,interacting withnucleosomes and histone H2A/H2B dimers,indicating that it may promote nucleosome disruption upon transcription (seeFACT140)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSRP1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSRP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SSRP1 (NM_003146) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSRP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSRP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSRP1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SSRP1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ssrp1tm1Rul for SSRP1
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ssrp1):
SSRP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SSRP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | Late Phase of HIV Life Cycle | | | 3 | Transcription | | | 4 | HIV Infection | | | 5 | Disease | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for SSRP1
5/20 
Reactome Pathways for SSRP1 (see all 20)
SSRP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSRP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/344 Interacting proteins for SSRP1 (Q089452, 3 ENSP000002784124) via UniProtKB, MINT, STRING, and/or I2D (see all 344)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006260 | DNA replication |
IEA | -- | | GO:0006281 | DNA repair |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- | | GO:0006368 | transcription elongation from RNA polymerase II promoter |
TAS | -- |
SSRP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSRP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SSRP1 for compounds About GeneDecksing
 Browse Tocris compounds for SSRP1
2 Novoseek chemical compound relationships for SSRP1 gene About this table
Search CenterWatch for drugs/clinical trials and news about SSRP1
|
Transcripts
for SSRP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSRP1 gene: NM_003146.2 Unigene Cluster for SSRP1: Structure specific recognition protein 1 Hs.523680 [show with all ESTs]Unigene Representative Sequence: M867374 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000278412(uc010rjq.1 uc001njt.3) ENST00000293880 ENST00000526696
ENST00000529002
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSRP1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSRP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SSRP1 (NM_003146) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSRP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSRP1 |
Additional cDNA sequence: BC005116.1 BC091486.1 M86737.1 17 DOTS entries: DT.101971459 DT.218848 DT.95351445 DT.120751498 DT.97855369 DT.120751476 DT.120751487 DT.40116821 DT.100816084 DT.92001705 DT.95270817 DT.95270819 DT.100801846 DT.100816666 DT.100868799 DT.120751500 DT.97864763 24/560 AceView cDNA sequences (see all 560): AI769368 AI927125 BM828622 AW196881 BQ925013 CD652357 BQ574262 BQ230526 BU902353 CA395252 BQ063107 AI630694 BQ070980 BE328192 AL138347 BQ891823 BQ181839 AA983384 AI669267 BU161799 BE393917 BI086872 AA312302 BQ220343
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SSRP1 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SSRP1
|
Expression
for SSRP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSRP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SSRP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSRP1
SOURCE GeneReport for Unigene cluster: Hs.523680
SABiosciences Custom PCR Arrays for SSRP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSRP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSRP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSRP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSRP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSRP1 |
Orthologs
for SSRP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SSRP1 gene from 8/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SSRP11 |
structure specific recognition protein 1 |
82.55(n)
91.56(a) |
|
396509 NM_001005796.1 NP_001005796.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SSRP16 |
-- |
89(a) |
1 ↔ 1 |
1(92125745-92137354) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.3362 |
Xenopus laevis mRNA for DUF87, complete cds |
78.03(n) |
|
AB004793.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.206902 |
Danio rerio cDNA clone MGC66086 IMAGE6797288, complete more |
79.38(n) |
|
BC056311.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ssrp1 , 3 |
single-stranded DNA binding3
Structure specific recognition protein1 |
56(a)3
57.94(n)1
52.68(a)1 |
|
60A23
377671 NM_079106.21 NP_523830.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
hmg-41 , 3 |
Protein HMG-41 |
40(a)
(best of 2)3
50.07(n)1
43.24(a)1 |
|
III(7451023-7453337)3
1760521 NM_066232.41 NP_498633.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HMG1 |
FACT complex subunit SSRP1 |
47.67(n)
37.04(a) |
|
822505 NM_113794.3 NP_189515.1 |
rice
(Oryza sativa) |
Liliopsida |
Os01g01849001 |
hypothetical protein |
48.05(n)
34.95(a) |
|
4325652 NM_001048772.1 NP_001042237.1 |
ENSEMBL Gene Tree for SSRP1 (if available)
TreeFam Gene Tree for SSRP1 (if available) |
Paralogs
for SSRP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SSRP1 gene
- HMG20B2 HMG20A2
1 SIMAP similar gene for SSRP1 using alignment to 4 protein entries: SSRP1_HUMAN (see all proteins):HMGB2
SSRP1 for paralogs About GeneDecksing
|
Genomic Variants
for SSRP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSRP1 (57093459 - 57103351 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SSRP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSRP1 |
|
Disorders
/ Diseases
for SSRP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSRP1 for disorders About GeneDecksing
OMIM gene information: 604328
OMIM disorders: --
5  diseases for SSRP1: About MalaCardssystemic lupus erythematosus lupus erythematosus kaposi's sarcoma sarcoma
ovarian cancer
Export disorders for SSRP1 gene to outside databases
|
Publications
for SSRP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSRP1 gene, integrated from 9 sources (see all 101):
(articles sorted by number of sources associating them with SSRP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. (PubMed id 1372440)1, 2, 3, 9 Bruhn S.L.... Lippard S.J. (1992)
- Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. (PubMed id 11344167)1, 2, 9 Yarnell A.T.... Lippard S.J. (2001)
- CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. (PubMed id 15659405)1, 2, 9 Li Y.... Lu H. (2005)
- SSRP1 functions as a co-activator of the transcriptional activator p63. (PubMed id 12374749)1, 2, 9 Zeng S.X.... Lu H. (2002)
- Coupling caspase cleavage and ubiquitin-proteasome-dependent degradation of SSRP1 during apoptosis. (PubMed id 16498457)1, 2, 9 Landais I.... Lu H. (2006)
- The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. (PubMed id 9566881)1, 2, 9 Dyer M.A.... Baron M.H. (1998)
- High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases. (PubMed id 11824977)1, 2, 9 Santoro P....Gariglio M. (2002)
- A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PubMed id 11239457)1, 2, 9 Keller D.M....Lu H. (2001)
- p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. (PubMed id 12393879)1, 2, 9 Keller D.M. and Lu H. (2002)
- The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PubMed id 10421373)1, 2, 9 Orphanides G.... Reinberg D. (1999)
|
External Searches for SSRP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SSRP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing SSRP1 gene
(According to HUGE)
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Specialized Databases showing SSRP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for SSRP1 gene:
Search GeneIP for patents involving SSRP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SSRP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for SSRP1 | | OriGene shRNA RFP for SSRP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSRP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSRP1 | | | OriGene Protein Over-expression Lysate for SSRP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SSRP1 | | OriGene 3'-UTR Clone for SSRP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSRP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSRP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SSRP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SSRP1 | | OriGene Custom Protein Services for SSRP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSRP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSRP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSRP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSRP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSRP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSRP1 |
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| | Antibodies & Assays for SSRP1 |
| | | | Search Tocris compounds for SSRP1 |
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 | | | SSRP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSRP1 |
|  |  |  | | | | ThermoFisher Antibodies for SSRP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSRP1 |
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