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Aliases for SSRP1 Gene

Aliases for SSRP1 Gene

  • Structure Specific Recognition Protein 1 2 3
  • Chromatin-Specific Transcription Elongation Factor 80 KDa Subunit 3 4
  • Facilitates Chromatin Transcription Complex 80 KDa Subunit 3 4
  • Facilitates Chromatin Transcription Complex Subunit SSRP1 3 4
  • Recombination Signal Sequence Recognition Protein 1 3 4
  • Facilitates Chromatin Remodeling 80 KDa Subunit 2 3
  • Structure-Specific Recognition Protein 1 3 4
  • FACT 80 KDa Subunit 3 4
  • FACTp80 3 4
  • FACT80 3 4
  • HSSRP1 3 4
  • FACT 3 6
  • T160 3 4
  • FACT Complex Subunit SSRP1 3
  • High Mobility Group Box 3
  • Cisplatin-DNA SSRP 3

External Ids for SSRP1 Gene

Previous GeneCards Identifiers for SSRP1 Gene

  • GC11M059487
  • GC11M058606
  • GC11M056868
  • GC11M056850
  • GC11M057093
  • GC11M053442

Summaries for SSRP1 Gene

Entrez Gene Summary for SSRP1 Gene

  • The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSRP1 Gene

SSRP1 (Structure Specific Recognition Protein 1) is a Protein Coding gene. Among its related pathways are Disease and Gene Expression. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TOX2.

UniProtKB/Swiss-Prot for SSRP1 Gene

  • Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Gene Wiki entry for SSRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSRP1 Gene

Genomics for SSRP1 Gene

Regulatory Elements for SSRP1 Gene

Genomic Location for SSRP1 Gene

Start:
57,325,985 bp from pter
End:
57,335,877 bp from pter
Size:
9,893 bases
Orientation:
Minus strand

Genomic View for SSRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSRP1 Gene

Proteins for SSRP1 Gene

  • Protein details for SSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08945-SSRP1_HUMAN
    Recommended name:
    FACT complex subunit SSRP1
    Protein Accession:
    Q08945
    Secondary Accessions:
    • Q5BJG8

    Protein attributes for SSRP1 Gene

    Size:
    709 amino acids
    Molecular mass:
    81075 Da
    Quaternary structure:
    • Interacts with MYOG (via C-terminal region) (By similarity). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Binds to histone H3-H4 tetramers, but not to intact nucleosomes. Interacts with isoform gamma of TP63. Interacts with FYTTD1/UIF, SRF and NEK9.
    Miscellaneous:
    • Autoantibodies against SSRP1 are present in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases
    SequenceCaution:
    • Sequence=AAH91486.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SSRP1 Gene

neXtProt entry for SSRP1 Gene

Proteomics data for SSRP1 Gene at MOPED

Post-translational modifications for SSRP1 Gene

  • Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.
  • Sumoylated.
  • Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein.
  • Ubiquitination at Lys15, Lys39, Lys63, Lys84, Lys90, Lys105, Lys228, Lys233, Lys304, Lys319, Lys325, and Lys566
  • Modification sites at PhosphoSitePlus

Other Protein References for SSRP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SSRP1 Gene

Domains for SSRP1 Gene

Suggested Antigen Peptide Sequences for SSRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08945

UniProtKB/Swiss-Prot:

SSRP1_HUMAN :
  • Q08945
Domain:
  • The HMG box DNA-binding domain mediates DNA-binding. It has both affinity and specificity for DNA damaged globally with cisplatin.
  • Contains 1 HMG box DNA-binding domain.
Family:
  • Belongs to the SSRP1 family.
genes like me logo Genes that share domains with SSRP1: view

No data available for Gene Families for SSRP1 Gene

Function for SSRP1 Gene

Molecular function for SSRP1 Gene

GENATLAS Biochemistry: structure specific recognition protein 1,essential for transcription,binding specifically to DNA modified by the anticancer agent cysplatin,81kDa,80kDa subunit of the chromatin specific elongation factor FACT,interacting with nucleosomes and histone H2A/H2B dimers,indicating that it may promote nucleosome disruption upon transcription (see FACT140)
UniProtKB/Swiss-Prot Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Gene Ontology (GO) - Molecular Function for SSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 16902406
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SSRP1: view

Phenotypes for SSRP1 Gene

genes like me logo Genes that share phenotypes with SSRP1: view

Animal Models for SSRP1 Gene

MGI Knock Outs for SSRP1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SSRP1 Gene

Localization for SSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSRP1 Gene

Nucleus. Nucleus, nucleolus. Chromosome. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSRP1 Gene COMPARTMENTS Subcellular localization image for SSRP1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SSRP1: view

Pathways for SSRP1 Gene

genes like me logo Genes that share pathways with SSRP1: view

Pathways by source for SSRP1 Gene

1 Cell Signaling Technology pathway for SSRP1 Gene

Gene Ontology (GO) - Biological Process for SSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006338 chromatin remodeling IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with SSRP1: view

Compounds for SSRP1 Gene

(2) Novoseek inferred chemical compound relationships for SSRP1 Gene

Compound -log(P) Hits PubMed IDs
cisplatin 32.5 15
serine 3.95 1
genes like me logo Genes that share compounds with SSRP1: view

Transcripts for SSRP1 Gene

Unigene Clusters for SSRP1 Gene

Structure specific recognition protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSRP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - -
SP2: -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for SSRP1 Gene

GeneLoc Exon Structure for
SSRP1
ECgene alternative splicing isoforms for
SSRP1

Expression for SSRP1 Gene

mRNA expression in normal human tissues for SSRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSRP1 Gene

SOURCE GeneReport for Unigene cluster for SSRP1 Gene Hs.523680

genes like me logo Genes that share expressions with SSRP1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSRP1 Gene

Orthologs for SSRP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSRP1 35
  • 99.29 (n)
  • 99.01 (a)
SSRP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSRP1 35
  • 89.99 (n)
  • 99.29 (a)
SSRP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSRP1 35
  • 91.77 (n)
  • 98.45 (a)
SSRP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssrp1 35
  • 89.03 (n)
  • 97.03 (a)
Ssrp1 16
Ssrp1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSRP1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ssrp1 35
  • 89.89 (n)
  • 97.74 (a)
chicken
(Gallus gallus)
Aves SSRP1 35
  • 81.74 (n)
  • 90.13 (a)
SSRP1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSRP1 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.336 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssrp1 35
  • 72.84 (n)
  • 80.75 (a)
Str.15184 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9262 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20690 35
ssrp1a 36
  • 74 (a)
OneToMany
ssrp1b 35
  • 70.91 (n)
  • 76.39 (a)
ssrp1b 36
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012335 35
  • 59.83 (n)
  • 55.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7045 36
  • 29 (a)
OneToMany
CG7046 36
  • 28 (a)
OneToMany
HmgD 36
  • 48 (a)
OneToMany
HmgZ 36
  • 50 (a)
OneToMany
Ssrp 35
  • 56.63 (n)
  • 51.44 (a)
Ssrp 36
  • 50 (a)
OneToMany
Ssrp 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea hmg-3 36
  • 39 (a)
OneToMany
hmg-4 35
  • 50.44 (n)
  • 43.05 (a)
hmg-4 36
  • 41 (a)
OneToMany
hmg-4 37
  • 40 (a)
hmg-3 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POB3 36
  • 32 (a)
OneToMany
POB3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HMG 35
  • 47.51 (n)
  • 36.29 (a)
rice
(Oryza sativa)
Liliopsida Os01g0184900 35
  • 48.12 (n)
  • 35.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.538 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5813 36
  • 54 (a)
OneToOne
Species with no ortholog for SSRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSRP1 Gene

ENSEMBL:
Gene Tree for SSRP1 (if available)
TreeFam:
Gene Tree for SSRP1 (if available)

Paralogs for SSRP1 Gene

Paralogs for SSRP1 Gene

Selected SIMAP similar genes for SSRP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SSRP1: view

Variants for SSRP1 Gene

Sequence variations from dbSNP and Humsavar for SSRP1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs768436 - 57,332,720(+) ATGCA(C/G)GTGCA reference, missense
rs2230648 -- 57,332,187(-) CTGGT(A/G/T)AACCG reference, synonymous-codon
rs2230649 -- 57,334,622(-) AGCCG(C/T)CAGGG synonymous-codon, reference
rs2230650 -- 57,332,751(-) CGTTA(C/T)GACAT synonymous-codon, reference
rs4432037 -- 57,336,323(+) ACTGT(C/T)AAGTT upstream-variant-2KB

Relevant External Links for SSRP1 Gene

HapMap Linkage Disequilibrium report
SSRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SSRP1 Gene

Disorders for SSRP1 Gene

No disorders were found for SSRP1 Gene.

No data available for UniProtKB/Swiss-Prot for SSRP1 Gene

Publications for SSRP1 Gene

  1. Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. (PMID: 1372440) Bruhn S.L. … Lippard S.J. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. (PMID: 9566881) Dyer M.A. … Baron M.H. (Mol. Cell. Biol. 1998) 3 4 23
  3. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. (PMID: 10421373) Orphanides G. … Reinberg D. (Nature 1999) 3 4 23
  4. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. (PMID: 11239457) Keller D.M. … Lu H. (Mol. Cell 2001) 3 4 23
  5. Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. (PMID: 11344167) Yarnell A.T. … Lippard S.J. (J. Biol. Chem. 2001) 3 4 23

Products for SSRP1 Gene

Sources for SSRP1 Gene

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