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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SSR4 Gene

protein-coding GIFtS: 57
GCID: GC0XP153058

signal sequence receptor, delta

Explore 4 diseases affiliated with
SSR4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Signal Sequence Receptor, Delta¹ ²		TRAP-Delta¹
TRAPD¹ ² ³ ⁵		Translocon-Associated Protein Delta²
Signal Sequence Receptor Subunit Delta² ³		Translocon-Associated Protein Subunit Delta²
SSR-Delta¹

External Ids:	HGNC: 11326¹	Entrez Gene: 6748²	Ensembl: ENSG00000180879⁷	OMIM: 300090⁵	UniProtKB: P51571³

ORGUL members:
	NONCODE:n410677

Export aliases for SSR4 gene to outside databases

Previous GC identifers: GC0XP147197 GC0XP149515 GC0XP150644 GC0XP151526 GC0XP151527 GC0XP152579 GC0XP152712 GC0XP141717

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSR4:

This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating

proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged

in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a

CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.(provided by RefSeq,

Mar 2011)

UniProtKB/Swiss-Prot: SSRD_HUMAN, P51571

Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate

the retention of ER resident proteins

Gene Wiki entry for SSR4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167198.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SSR4 gene promoter:
c-Fos TBP NF-1/L NF-1 AP-1 HEN1 Zic1 FOXO1a ZIC2/Zic2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSR4 promoter sequence

Search SABiosciences Chromatin IP Primers for SSR4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSR4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

SSR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSR4 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP153058: view genomic region (about GC identifiers)

Start:	153,058,971 bp from pter	End:	153,063,960 bp from pter
Size:	4,990 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SSRD_HUMAN, P51571 (See protein sequence)

Recommended Name: Translocon-associated protein subunit delta precursor

Size: 173 amino acids; 18999 Da

Subunit: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein

Secondary accessions: A8K378 Q53XY1

Explore the universe of human proteins at neXtProt for SSR4: NX_P51571

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51571

SSR4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001191455.1 NP_001191456.1 NP_006271.1

ENSEMBL proteins:

ENSP00000317331 ENSP00000359104 ENSP00000359103 ENSP00000359102 ENSP00000399650

Reactome Protein details: P51571
Human Recombinant Protein Products for SSR4:

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	Novus Biologicals SSR4 Protein Novus Biologicals SSR4 Lysate
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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	--	--
GO:0005784	Sec61 translocon complex	NAS	7492314
GO:0016021	integral to membrane	IEA	--

SSR4 for ontologies About GeneDecksing

SSR4 Antibody Products:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SSR4 for domains About GeneDecksing

1 InterPro domain/family:

IPR008855 TRAP-delta

Graphical View of Domain Structure for InterPro Entry P51571

ProtoNet protein and cluster: P51571

1 Blocks protein family: IPB008855 Translocon-associated

UniProtKB/Swiss-Prot: SSRD_HUMAN, P51571

Similarity: Belongs to the TRAP-delta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SSRD_HUMAN, P51571

Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate

the retention of ER resident proteins

Genatlas biochemistry entry for SSR4:

signal sequence receptor delta,with an alternative polyadenylation site,expressed in many tissues

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	NAS	--

SSR4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for SSR4:

Decreased viability of wild-ty

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SSR4

miRNA Products:		OriGene 3'-UTR Clone: SSR4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSR4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SSR4
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSR4 (see all 7) OriGene shRNA RFP: SSR4 Browse OriGene siRNA
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SSR4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSR4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSR4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SSR4 (NM_001204527)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR4

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of PB1-F2

SRP-dependent cotranslational protein targeting to membrane

0.77

Translation

0.57

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

1.00

Generic Transcription Pathway

Gene Expression

0.46

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for SSR4

	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Metabolism of proteins
	Gene Expression

1 Kegg Pathway (Kegg details for SSR4):

Protein processing in endoplasmic reticulum

SSR4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SSR4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/186 Interacting proteins for SSR4 (P51571^{1, 2, 3} ENSP00000317331⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 186)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C20orf24	Q9BUV8¹^,³, ENSP00000341213⁴	EBI-1054539,EBI-1050079 I2D: score=2 STRING: ENSP00000341213
CBWD1	Q9BRT8¹^,³, ENSP00000348915⁴	EBI-1054539,EBI-1054417 I2D: score=1 STRING: ENSP00000348915
SSR1	P43307²^,³, ENSP00000244763⁴	MINT-4546703 I2D: score=1 STRING: ENSP00000244763
MAP3K1	Q13233²^,³	MINT-48297 I2D: score=2
PHLDA3	Q9Y5J5¹^,³	EBI-1054539,EBI-1055859 I2D: score=2

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	TAS	--
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	--
GO:0006886	intracellular protein transport	NAS	--
GO:0010467	gene expression	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

SSR4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SSR4

1 HMDB Compound for SSR4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about SSR4 / SSRD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SSR4 gene (3 alternative transcripts):

NM_001204526.1 NM_001204527.1 NM_006280.2

Unigene Cluster for SSR4:

Signal sequence receptor, delta

Hs.409223 [show with all ESTs]

Unigene Representative Sequence: BC032351

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000320857(uc022chw.1 uc004fiv.3) ENST00000491833 ENST00000370087

ENST00000482902(uc022chx.1) ENST00000370086(uc004fiw.3) ENST00000460616

ENST00000370085 ENST00000471724 ENST00000471880 ENST00000489777 ENST00000486204

ENST00000485612 ENST00000447375

miRNA Products:		OriGene 3'-UTR Clone: SSR4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSR4
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SSR4
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSR4 (see all 7) OriGene shRNA RFP: SSR4 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSR4
		Sirion Biotech Custom design and validation of potent shRNA sequences against SSR4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSR4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSR4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SSR4 (NM_001204527)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR4
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSR4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSR4

Additional cDNA sequence:

AK290493.1 BC003371.1 BC015362.2 BC032351.1 BT007192.1 NR_037927.1 X90583.1 Z69043.1

20 DOTS entries:

DT.95164179 DT.100854831 DT.100854838 DT.121309368 DT.100854830 DT.121309436 DT.319744 DT.95164167

DT.95142095 DT.100854840 DT.97864675 DT.121309359 DT.100854819 DT.91829470 DT.100854823 DT.100854827

DT.100854842 DT.102836114 DT.121309469 DT.92447436

24/636 AceView cDNA sequences (see all 636):

BM509241 BG683912 BG034166 BM997363 AL549183 AI989423 CD513596 AI636819

N25286 W37497 BM764392 BI114939 BM841601 BX644493 BM841533 AA552687

BQ672202 NM_006280 AA437238 BM910726 BQ005874 BE396017 BM842086 BU163456

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SSR4 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b
SP1:													-						-		-		-		-		-												-
SP2:													-		-		-		-		-		-		-		-												-
SP3:															-		-		-		-		-		-		-												-
SP4:																																							-
SP5:													-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for SSR4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SSR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTCTCTATG

About this image

SSR4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Endochondral Facial Bones

Bone

Cartilage

Meckel's Cartilage

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SSR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSR4

SOURCE GeneReport for Unigene cluster: Hs.409223

SABiosciences Custom PCR Arrays for SSR4

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSR4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSR4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SSR4 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ssr4^{1 , 5}	signal sequence receptor, delta^{1, 5}	86.63(n)¹ 95.35(a)¹		X (37.41 cM)⁵ 20832¹ NM_009279.3¹ NP_033305.1¹ 73787062⁵
lizard (Anolis carolinensis)	Reptilia	SSR4⁶	--	72(a)	1 ↔ 1	2(87858930-87868367)
African clawed frog (Xenopus laevis)	Amphibia	X90584.1²	--	73.73(n)		X90584.1
zebrafish (Danio rerio)	Actinopterygii	wufe06a08²	Transcribed sequence with moderate similarity to protein more	73.57(n)		CD778039.1
fruit fly (Drosophila melanogaster)	Insecta	Tapdelta¹	Translocon-associated protein delta	48.64(n) 35.22(a)		45680 NM_136835.3 NP_610679.1
worm (Caenorhabditis elegans)	Secernentea	trap-4⁶	TRanslocon-Associated Protein family member (trap-...	33(a)	1 ↔ 1	III(11920616-11921518)

ENSEMBL Gene Tree for SSR4 (if available)
TreeFam Gene Tree for SSR4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SSR4 gene

SSR4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SSR4
PGOHUM00000239095

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs201193740^1,2		--	153061989(+)	`CTGACA/GTGCAA`	7	T	nc-transcript-variantsyn¹		0	--	--	--	--
rs187781901^1,2		--	153062448(+)	`CTCCTC/TTCAGT`	4	--	int¹		0	--	--	--	--
rs148870473^1,2		--	153062463(+)	`TAAGTA/GGCTGG`	4	--	int¹		0	--	--	--	--
rs192466768^1,2		--	153062588(+)	`GGGCAC/TCCCTG`	4	--	int¹		0	--	--	--	--
rs12009356^1,2	C,F,H	--	153062668(+)	`TCAACA/GGGGTT`	4	--	int¹		10		NS EA NA CSA	1099
rs113178975^1,2	C	--	153062699(+)	`CGGCCG/ATGGGG`	4	--	int¹		1		CSA	1
rs5945165^1,2	C,F,H	--	153062772(+)	`GTTACC/TTGGTA`	4	--	int¹		13		NS EA WA NA CSA	437
rs11795888^1,2	C,F,H	--	153062801(+)	`GCAGCC/TCCCAA`	4	--	int¹		5		NS EA NA	420
rs80006970^1,2	C	--	153062829(+)	`ACCTGA/CAGGCC`	4	--	int¹		0	--	--	--	--
rs41301321^1,2	C	--	153062853(+)	`ACAGGA/GCTCCT`	4	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SSR4 (153058971 - 153063960 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SSR4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSR4

DNA2.0 Custom Variant and Variant Library Synthesis for SSR4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SSR4 for disorders           About GeneDecksing

OMIM gene information: 300090    OMIM disorders: --

4 diseases for SSR4:    About MalaCards

terminal osseous dysplasia osseous dysplasia retinitis melanoma

Export disorders for SSR4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SSR4 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with SSR4)

Utopia: connect your pdf to the dynamic
world of online information

Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. (PubMed id 9286695)^{1, 2, 3, 9} Brenner V.... Platzer M. (1997)
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)^{1, 2} Meierhofer D.... Kaiser P. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary. (PubMed id 7492314)^{1, 2} Holthuis J.C.M.... Martens G.J.M. (1995)
Cloning and molecular characterization of a human ortholog of Monodelphis TRAPD in ultraviolet B-induced melanoma. (PubMed id 15057039)^{1, 9} Wang Z. and VandeBerg J.L. (2004)
NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. (PubMed id 14684739)^{1, 9} Miyazaki K....Nakagawara A. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6748	HGNC: 11326	AceView: SSR4	Ensembl:ENSG00000180879	euGenes: HUgn6748
ECgene: SSR4	Kegg: 6748	H-InvDB: SSR4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SSR4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SSR4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SSR4 gene:
Search GeneIP for patents involving SSR4

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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signal sequence receptor, delta

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signal sequence receptor, delta

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