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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSR3 Gene

protein-coding   GIFtS: 49
GCID: GC03M156257

Signal Sequence Receptor, Gamma (Translocon-Associated Protein...

  Search for SSR3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Sequence Receptor, Gamma (Translocon-Associated Protein
Gamma)1 2
     SSR Gamma2
Signal Sequence Receptor Subunit Gamma2 3     Translocon-Associated Protein Gamma Subunit2
SSR-gamma2 3     Translocon-Associated Protein Subunit Gamma2
TRAP-gamma2 3     TRAP-Complex Gamma Subunit2
TRAPG2 3     

External Ids:    HGNC: 113251   Entrez Gene: 67472   Ensembl: ENSG000001148507   OMIM: 6062135   UniProtKB: Q9UNL23   

Export aliases for SSR3 gene to outside databases

Previous GC identifers: GC03M153272 GC03M157205 GC03M157539 GC03M157579 GC03M157741 GC03M153653


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSR3 Gene:
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with
protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha,
beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits.
This gene encodes the gamma subunit, which is predicted to span the membrane four times. (provided by RefSeq, Aug
2010)

GeneCards Summary for SSR3 Gene: 
SSR3 (signal sequence receptor, gamma (translocon-associated protein gamma)) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation and Generic Transcription Pathway.

UniProtKB/Swiss-Prot: SSRG_HUMAN, Q9UNL2
Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
regulate the retention of ER resident proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSR3 gene promoter:
         AML1a   ATF-2   CUTL1   POU6F1 (c2)   C/EBPalpha   POU2F1   FOXO4   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q25.31

SSR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSR3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M156257:  view genomic region     (about GC identifiers)

Start:
156,257,929 bp from pter      End:
156,272,973 bp from pter
Size:
15,045 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSRG_HUMAN, Q9UNL2 (See protein sequence)
Recommended Name: Translocon-associated protein subunit gamma  
Size: 185 amino acids; 21080 Da
Subunit: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: B2R7D0 D3DNK5 Q549M4

Explore the universe of human proteins at neXtProt for SSR3: NX_Q9UNL2

Explore proteomics data for SSR3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UNL2

  • SSR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSR3 Protein Expression
    REFSEQ proteins: NP_009038.1  
    ENSEMBL proteins: 
     ENSP00000265044   ENSP00000420641   ENSP00000417530   ENSP00000417306   ENSP00000420087  
    Reactome Protein details: Q9UNL2
    Human Recombinant Protein Products for SSR3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SSR3
    OriGene Protein Over-expression Lysate for SSR3
    OriGene MassSpec for SSR3 
    OriGene Custom Protein Services for SSR3
    GenScript Custom Purified and Recombinant Proteins Services for SSR3
    Novus Biologicals SSR3 Protein
    Novus Biologicals SSR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005784Sec61 translocon complex IEA--
    GO:0030176integral to endoplasmic reticulum membrane IEA--

    SSR3 for ontologies           About GeneDecksing



    SSR3 Antibody Products: 
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    Novus Biologicals SSR3 Antibody
    Abcam antibodies for SSR3
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for SSR3
    Search LSBio for Antibodies for SSR3 

    Assay Products for SSR3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SSR3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009779 TRAP-gamma

    Graphical View of Domain Structure for InterPro Entry Q9UNL2

    ProtoNet protein and cluster: Q9UNL2

    UniProtKB/Swiss-Prot: SSRG_HUMAN, Q9UNL2
    Similarity: Belongs to the TRAP-gamma family


    SSR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSRG_HUMAN, Q9UNL2
    Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
    regulate the retention of ER resident proteins

    Phenotypes:
         2 GenomeRNAi human phenotypes for SSR3:

     Increased G1 DNA content  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ssr3):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 
     respiratory system 

    SSR3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSR3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSR3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSR3
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SSR3 (see all 62):
    hsa-miR-579 hsa-miR-607 hsa-miR-4307 hsa-miR-3664-5p hsa-miR-429 hsa-miR-30d hsa-miR-218 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSSR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SSR3
    Sirion Biotech Customized adenovirus for overexpression of SSR3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SSR3 (see all 7)
    OriGene ORF clones in mouse, rat for SSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR3 (NM_007107)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR3
    Sirion Biotech Customized lentivirus for stable overexpression of SSR3 
                         Customized lentivirus expression plasmids for stable overexpression of SSR3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SSR3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSR3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Translation0.78
    SRP-dependent cotranslational protein targeting to membrane0.77
    2Generic Transcription Pathway
    Gene Expression0.47
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SSR3
        Translation
    SRP-dependent cotranslational protein targeting to membrane
    Metabolism of proteins
    Gene Expression


    1         Kegg Pathway  (Kegg details for SSR3):
        Protein processing in endoplasmic reticulum


    SSR3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for SSR3 (Q9UNL21, 2, 3 ENSP000002650444) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486341, 2, 3, ENSP000003874774EBI-1043938,EBI-347545 MINT-62629 MINT-62727 MINT-62803 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486341, 2, 3, ENSP000004153634EBI-1043938,EBI-347545 MINT-62629 MINT-62727 MINT-62803 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486341, 2, 3, ENSP000003651754EBI-1043938,EBI-347545 MINT-62629 MINT-62727 MINT-62803 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486341, 2, 3EBI-1043938,EBI-347545 MINT-62629 MINT-62727 MINT-62803 I2D: score=5 
    ENSG00000225164P486341, 2, 3EBI-1043938,EBI-347545 MINT-62629 MINT-62727 MINT-62803 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane ----
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--

    SSR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSR3 (SSRG)

    1 HMDB Compound for SSR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about SSR3 / SSRG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSR3 gene: 
    NM_007107.3  

    Unigene Cluster for SSR3:

    Signal sequence receptor, gamma (translocon-associated protein gamma)
    Hs.518346  [show with all ESTs]
    Unigene Representative Sequence: NM_007107
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265044(uc003fau.3 uc011bop.2) ENST00000467789 ENST00000498205
    ENST00000476217 ENST00000478842 ENST00000464138 ENST00000463503 ENST00000496050
    ENST00000467733
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSR3
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate SSR3 (see all 62):
    hsa-miR-579 hsa-miR-607 hsa-miR-4307 hsa-miR-3664-5p hsa-miR-429 hsa-miR-30d hsa-miR-218 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSSR3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSR3
    Clone
    Products:
         
    OriGene clones in human, mouse for SSR3 (see all 7)
    OriGene ORF clones in mouse, rat for SSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR3 (NM_007107)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR3
    Sirion Biotech Customized lentivirus for stable overexpression of SSR3 
                         Customized lentivirus expression plasmids for stable overexpression of SSR3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SSR3
    OriGene qSTAR qPCR primer pairs in human, mouse for SSR3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSR3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSR3

    Additional mRNA sequence: 

    AF087907.1 AF110647.1 AK304364.1 AK312935.1 BC017203.1 BT006669.1 

    17 DOTS entries:

    DT.101986375  DT.100810852  DT.115848  DT.75100262  DT.403740  DT.95148683  DT.100810851  DT.120847381 
    DT.121441316  DT.100695502  DT.100810850  DT.120847361  DT.414831  DT.91923740  DT.95148665  DT.95362910 
    DT.95102337 

    24/400 AceView cDNA sequences (see all 400):

    BU150024 AL704898 AI421342 F05461 BM991545 Z38420 CB136862 AA515476 
    BC017203 AA337272 CR624148 BM663282 BX438765 BG564368 F05439 BM850723 
    AI375664 BE672567 BT006669 NM_007107 AL709061 AI913675 BU689366 W93528 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGCTTCAC
    SSR3 Expression
    About this image


    See SSR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSR3

    SOURCE GeneReport for Unigene cluster: Hs.518346
        SABiosciences Custom PCR Arrays for SSR3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SSR3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssr31 , 5 signal sequence receptor, gamma1, 5 91.89(n)1
    98.92(a)1
      3 (30.15 cM)5
    674371  NM_026155.31  NP_080431.11 
     653796555 
    chicken
    (Gallus gallus)
    Aves SSR31 signal sequence receptor, gamma (translocon-associated more 82.88(n)
    95.68(a)
      425027  XM_422829.3  XP_422829.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSR36
    Uncharacterized protein
    83(a)
    1 ↔ 1
    3(15488329-15492744)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642862 hypothetical protein MGC64286 80.04(n)    AB058505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01d072 wufb01d07 80.57(n)   337190  BC047859.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BEST:CK012963
    CG58851
    CG58851 62(a)3
    61.82(n)1
    65.92(a)1
      30E43
    343141  NM_135477.21  NP_609321.11 
    worm
    (Caenorhabditis elegans)
    Secernentea trap-31 Protein TRAP-3 51.64(n)
    41.04(a)
      177028  NM_067797.3  NP_500198.1 


    ENSEMBL Gene Tree for SSR3 (if available)
    TreeFam Gene Tree for SSR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSR3 gene

    SSR3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SSR3
    PGOHUM00000244765


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/398 SNPs in SSR3 are shown (see all 398)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438112921,2
    C--156257433(+) AAAGA-/CCCTCC 1 -- ds50010--------
    rs1898849901,2
    --156257524(+) TTTTCG/TCCATA 1 -- ds50010--------
    rs1405713771,2
    --156257705(+) TACATC/TTGATT 1 -- ds50010--------
    rs1447920461,2
    C--156257982(+) CACAAA/GAATTG 1 -- ut310--------
    rs10466661,2
    C,F,H--156258005(-) AATATG/AGAGAT 1 -- ut3111Minor allele frequency- A:0.12MN NS EA NA WA 924
    rs1386486971,2
    --156258120(+) CCGGGC/TGCGGT 1 -- ut310--------
    rs1418807261,2
    --156258123(+) GGCGCA/GGTGGC 1 -- ut310--------
    rs2014462931,2
    --156258157(+) TGGGA-/GGCCGA 1 -- ut310--------
    rs1833388761,2
    C--156258222(+) ACCCCA/GTCTCT 1 -- ut310--------
    rs130689041,2
    C,F--156258287(+) ctactC/Tggcag 1 -- ut312Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for SSR3 (156257929 - 156272973 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SSR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv877683CNV Gain21882294
    nsv829764CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SSR3
    DNA2.0 Custom Variant and Variant Library Synthesis for SSR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SSR3 for disorders           About MalaCards
    OMIM gene information: 606213    OMIM disorders: --


    SSR3 for disorders           About GeneDecksing


    Export disorders for SSR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSR3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SSR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    4. The global gene-expression profiles of U-937 human mac rophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    9. Quantitative nanoproteomics for protein complexes (QNa noPX) related to estrogen transcriptional action. (PubMed id 19805454)1 Cheng P.C....Chen S.H. (2010)
    10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6747 HGNC: 11325 AceView: SSR3 Ensembl:ENSG00000114850 euGenes: HUgn6747
    ECgene: SSR3 Kegg: 6747 H-InvDB: SSR3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSR3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSR3 gene:
    Search GeneIP for patents involving SSR3

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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