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Aliases for SSR3 Gene

Aliases for SSR3 Gene

  • Signal Sequence Receptor, Gamma (Translocon-Associated Protein Gamma) 2 3
  • TRAPG 3 4 6
  • Signal Sequence Receptor Subunit Gamma 3 4
  • TRAP-Gamma 3 4
  • SSR-Gamma 3 4
  • Translocon-Associated Protein Gamma Subunit 3
  • Translocon-Associated Protein Subunit Gamma 3
  • TRAP-Complex Gamma Subunit 3
  • SSR Gamma 3

External Ids for SSR3 Gene

Previous GeneCards Identifiers for SSR3 Gene

  • GC03M153272
  • GC03M157205
  • GC03M157539
  • GC03M157579
  • GC03M157741
  • GC03M156257
  • GC03M153653

Summaries for SSR3 Gene

Entrez Gene Summary for SSR3 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

GeneCards Summary for SSR3 Gene

SSR3 (Signal Sequence Receptor, Gamma (Translocon-Associated Protein Gamma)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Gene Expression.

UniProtKB/Swiss-Prot for SSR3 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR3 Gene

Genomics for SSR3 Gene

Regulatory Elements for SSR3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSR3 Gene

Start:
156,540,140 bp from pter
End:
156,555,184 bp from pter
Size:
15,045 bases
Orientation:
Minus strand

Genomic View for SSR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR3 Gene

Proteins for SSR3 Gene

  • Protein details for SSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNL2-SSRG_HUMAN
    Recommended name:
    Translocon-associated protein subunit gamma
    Protein Accession:
    Q9UNL2
    Secondary Accessions:
    • B2R7D0
    • B4E2P2
    • D3DNK5
    • Q549M4

    Protein attributes for SSR3 Gene

    Size:
    185 amino acids
    Molecular mass:
    21080 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma

    Alternative splice isoforms for SSR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSR3 Gene

Proteomics data for SSR3 Gene at MOPED

Post-translational modifications for SSR3 Gene

  • Ubiquitination at Lys8
  • Modification sites at PhosphoSitePlus

Other Protein References for SSR3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SSR3 Gene

Domains for SSR3 Gene

Protein Domains for SSR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNL2

UniProtKB/Swiss-Prot:

SSRG_HUMAN :
  • Q9UNL2
Family:
  • Belongs to the TRAP-gamma family.
genes like me logo Genes that share domains with SSR3: view

No data available for Gene Families for SSR3 Gene

Function for SSR3 Gene

Molecular function for SSR3 Gene

UniProtKB/Swiss-Prot Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins
genes like me logo Genes that share phenotypes with SSR3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SSR3 Gene

Localization for SSR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSR3 Gene COMPARTMENTS Subcellular localization image for SSR3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005784 Sec61 translocon complex IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SSR3: view

Pathways for SSR3 Gene

genes like me logo Genes that share pathways with SSR3: view

Pathways by source for SSR3 Gene

Gene Ontology (GO) - Biological Process for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0010467 gene expression TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SSR3: view

Compounds for SSR3 Gene

(1) HMDB Compounds for SSR3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SSR3: view

Transcripts for SSR3 Gene

Unigene Clusters for SSR3 Gene

Signal sequence receptor, gamma (translocon-associated protein gamma):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSR3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSR3 Gene

No ASD Table

Relevant External Links for SSR3 Gene

GeneLoc Exon Structure for
SSR3
ECgene alternative splicing isoforms for
SSR3

Expression for SSR3 Gene

mRNA expression in normal human tissues for SSR3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSR3 Gene

SOURCE GeneReport for Unigene cluster for SSR3 Gene Hs.518346

genes like me logo Genes that share expressions with SSR3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSR3 Gene

Orthologs for SSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSR3 35
  • 99.28 (n)
  • 100 (a)
SSR3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSR3 35
  • 93.69 (n)
  • 98.38 (a)
SSR3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSR3 35
  • 91.35 (n)
  • 98.92 (a)
SSR3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssr3 35
  • 91.89 (n)
  • 98.92 (a)
Ssr3 16
Ssr3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSR3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSR3 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssr3 35
  • 92.25 (n)
  • 98.92 (a)
chicken
(Gallus gallus)
Aves SSR3 35
  • 82.7 (n)
  • 95.68 (a)
SSR3 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSR3 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64286 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr3 35
  • 79.82 (n)
  • 95.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9105 35
zebrafish
(Danio rerio)
Actinopterygii LOC100535344 35
  • 80.54 (n)
  • 94.59 (a)
ssr3 36
  • 94 (a)
OneToMany
ssr3 36
  • 94 (a)
OneToMany
wufb01d07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008761 35
  • 64.12 (n)
  • 65.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5885 35
  • 61.82 (n)
  • 65.92 (a)
CG5885 36
  • 62 (a)
OneToOne
BEST:CK01296 37
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea trap-3 35
  • 51.53 (n)
  • 40.8 (a)
trap-3 36
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2581 36
  • 51 (a)
OneToOne
Species with no ortholog for SSR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR3 Gene

ENSEMBL:
Gene Tree for SSR3 (if available)
TreeFam:
Gene Tree for SSR3 (if available)

Paralogs for SSR3 Gene

Pseudogenes.org Pseudogenes for SSR3 Gene

genes like me logo Genes that share paralogs with SSR3: view

No data available for Paralogs for SSR3 Gene

Variants for SSR3 Gene

Sequence variations from dbSNP and Humsavar for SSR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8665 -- 156,541,696(-) AGTCA(C/T)ATATC utr-variant-3-prime
rs9296 -- 156,548,985(-) AGGGA(A/G)GATGC synonymous-codon, reference
rs1046618 -- 156,541,618(-) TGGCC(A/G/T)ACATG utr-variant-3-prime
rs1046619 -- 156,541,617(-) ggcca(A/G)catgg utr-variant-3-prime
rs1046666 -- 156,540,216(-) AATAT(A/G)GAGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SSR3 Gene

Variant ID Type Subtype PubMed ID
nsv829764 CNV Gain 17160897
nsv877683 CNV Gain 21882294

Relevant External Links for SSR3 Gene

HapMap Linkage Disequilibrium report
SSR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR3 Gene

Disorders for SSR3 Gene

No disorders were found for SSR3 Gene.

No data available for UniProtKB/Swiss-Prot for SSR3 Gene

Publications for SSR3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  5. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PMID: 18781797) Meierhofer D. … Kaiser P. (J. Proteome Res. 2008) 3

Products for SSR3 Gene

Sources for SSR3 Gene

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