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SSR3 Gene

protein-coding   GIFtS: 51
GCID: GC03M156257

Signal Sequence Receptor, Gamma (Translocon-Associated Protein...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Sequence Receptor, Gamma (Translocon-Associated Protein
Gamma)1 2
     SSR Gamma2
TRAPG2 3 5     Translocon-Associated Protein Gamma Subunit2
Signal Sequence Receptor Subunit Gamma2 3     Translocon-Associated Protein Subunit Gamma2
SSR-gamma2 3     TRAP-Complex Gamma Subunit2
TRAP-gamma2 3     

External Ids:    HGNC: 113251   Entrez Gene: 67472   Ensembl: ENSG000001148507   OMIM: 6062135   UniProtKB: Q9UNL23   

Export aliases for SSR3 gene to outside databases

Previous GC identifers: GC03M153272 GC03M157205 GC03M157539 GC03M157579 GC03M157741 GC03M153653


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSR3 Gene:
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with
protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha,
beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits.
This gene encodes the gamma subunit, which is predicted to span the membrane four times. (provided by RefSeq, Aug
2010)

GeneCards Summary for SSR3 Gene:
SSR3 (signal sequence receptor, gamma (translocon-associated protein gamma)) is a protein-coding gene.

UniProtKB/Swiss-Prot: SSRG_HUMAN, Q9UNL2
Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
regulate the retention of ER resident proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSR3 gene promoter:
         AML1a   ATF-2   CUTL1   POU6F1 (c2)   C/EBPalpha   POU2F1   FOXO4   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSR3 promoter sequence
   Search Chromatin IP Primers for SSR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.31   Ensembl cytogenetic band:  3q25.31   HGNC cytogenetic band: 3q25.31

SSR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSR3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M156257:  view genomic region     (about GC identifiers)

Start:
156,257,929 bp from pter      End:
156,272,973 bp from pter
Size:
15,045 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SSRG_HUMAN, Q9UNL2 (See protein sequence)
Recommended Name: Translocon-associated protein subunit gamma  
Size: 185 amino acids; 21080 Da
Subunit: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma
Secondary accessions: B2R7D0 D3DNK5 Q549M4

Explore the universe of human proteins at neXtProt for SSR3: NX_Q9UNL2

Explore proteomics data for SSR3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8
  • Modification sites at PhosphoSitePlus

  • See SSR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009038.1  
    ENSEMBL proteins: 
     ENSP00000265044   ENSP00000420641   ENSP00000417530   ENSP00000417306   ENSP00000420087  
    Reactome Protein details: Q9UNL2

    SSR3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SSR3
    OriGene Protein Over-expression Lysate for SSR3
    OriGene MassSpec for SSR3
    OriGene Custom Protein Services for SSR3
    GenScript Custom Purified and Recombinant Proteins Services for SSR3
    Novus Biologicals SSR3 Protein
    Novus Biologicals SSR3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SSR3 

     
    antibodies-online proteins for SSR3 (2 products) 

     
    antibodies-online peptides for SSR3

    SSR3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
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    OriGene Custom Antibody Services for SSR3
    Novus Biologicals SSR3 Antibody
    Abcam antibodies for SSR3
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SSR3
    antibodies-online antibodies for SSR3 

    SSR3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SSR3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SSR3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SSR3 
    antibodies-online kits for SSR3 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009779 TRAP-gamma

    Graphical View of Domain Structure for InterPro Entry Q9UNL2

    ProtoNet protein and cluster: Q9UNL2

    UniProtKB/Swiss-Prot: SSRG_HUMAN, Q9UNL2
    Similarity: Belongs to the TRAP-gamma family


    Find genes that share domains with SSR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSRG_HUMAN, Q9UNL2
    Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
    regulate the retention of ER resident proteins

    Phenotypes:
         2 GenomeRNAi human phenotypes for SSR3:

     Increased G1 DNA content  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ssr3):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     respiratory system 

    Find genes that share phenotypes with SSR3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SSR3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SSR3:
    hsa-mir-615-3p (MIRT039643), hsa-mir-148b-3p (MIRT019355), hsa-mir-122-5p (MIRT023217), hsa-mir-3177-3p (MIRT052802), hsa-mir-125b-5p (MIRT045912), hsa-mir-132-3p (MIRT021752)

    Block miRNA regulation of human, mouse, rat SSR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSR3 (see all 62):
    hsa-miR-579 hsa-miR-607 hsa-miR-4307 hsa-miR-3664-5p hsa-miR-429 hsa-miR-30d hsa-miR-218 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSSR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SSR3
    Predesigned siRNA for gene silencing in human, mouse, rat SSR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SSR3

    Clone
    Products:
         
    OriGene clones in human, mouse for SSR3 (see all 7)
    OriGene ORF clones in mouse, rat for SSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR3 (NM_007107)
    Sino Biological Human cDNA Clone for SSR3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SSR3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SSR3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSRG_HUMAN, Q9UNL2: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005784Sec61 translocon complex IEA--
    GO:0030176integral component of endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with SSR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with SSR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SSR3
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SSR3):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSR3
    Interactions:

        Search GeneGlobe Interaction Network for SSR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSR3 (Q9UNL22, 3 ENSP000002650444) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62629 MINT-62727 MINT-62803 I2D: score=5 STRING: ENSP00000387477
    ENSG00000231825P486342, 3, ENSP000004153634MINT-62629 MINT-62727 MINT-62803 I2D: score=5 STRING: ENSP00000415363
    PRRC2AP486342, 3, ENSP000003651754MINT-62629 MINT-62727 MINT-62803 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62629 MINT-62727 MINT-62803 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62629 MINT-62727 MINT-62803 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane ----
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with SSR3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSR3 (SSRG)

    1 HMDB Compound for SSR3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSR3 gene: 
    NM_007107.3  

    Unigene Cluster for SSR3:

    Signal sequence receptor, gamma (translocon-associated protein gamma)
    Hs.518346  [show with all ESTs]
    Unigene Representative Sequence: NM_007107
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265044(uc003fau.3 uc011bop.2) ENST00000467789 ENST00000498205
    ENST00000476217 ENST00000478842 ENST00000464138 ENST00000463503 ENST00000496050
    ENST00000467733
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SSR3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSR3 (see all 62):
    hsa-miR-579 hsa-miR-607 hsa-miR-4307 hsa-miR-3664-5p hsa-miR-429 hsa-miR-30d hsa-miR-218 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidSSR3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SSR3
    Predesigned siRNA for gene silencing in human, mouse, rat SSR3
    Clone
    Products:
         
    OriGene clones in human, mouse for SSR3 (see all 7)
    OriGene ORF clones in mouse, rat for SSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR3 (NM_007107)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SSR3
    OriGene qSTAR qPCR primer pairs in human, mouse for SSR3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSR3
      QuantiTect SYBR Green Assays in human, mouse, rat SSR3
      QuantiFast Probe-based Assays in human, mouse, rat SSR3

    Additional mRNA sequence: 

    AF087907.1 AF110647.1 AK304364.1 AK312935.1 BC017203.1 BT006669.1 

    17 DOTS entries:

    DT.101986375  DT.100810852  DT.115848  DT.75100262  DT.403740  DT.95148683  DT.100810851  DT.120847381 
    DT.121441316  DT.100695502  DT.100810850  DT.120847361  DT.414831  DT.91923740  DT.95148665  DT.95362910 
    DT.95102337 

    Selected AceView cDNA sequences (see all 400):

    CB136862 AI421342 BX419591 BU689366 CA414483 AL708674 BU617370 F01720 
    W93528 AI139278 AA424631 AI276831 CR624148 BC017203 AI913675 BU150024 
    BM127709 AI953724 BU624207 CB126277 BQ636999 CB528712 BE672385 BE672567 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGCTTCAC
    SSR3 Expression
    About this image

    SSR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSR3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518346
        Custom PCR Arrays for SSR3
    Primer
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    OriGene qPCR primer pairs and template standards for SSR3
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    QuantiFast Probe-based Assays in human, mouse, rat SSR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SSR3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssr31 , 5 signal sequence receptor, gamma1, 5 91.89(n)1
    98.92(a)1
      3 (30.15 cM)5
    674371  NM_026155.31  NP_080431.11 
     653796555 
    chicken
    (Gallus gallus)
    Aves SSR31 signal sequence receptor, gamma (translocon-associated more 82.7(n)
    95.68(a)
      425027  NM_001277475.1  NP_001264404.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSR36
    signal sequence receptor, gamma (translocon-associ...
    82(a)
    1 ↔ 1
    3(15488329-15492744)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC642862 hypothetical protein MGC64286 80.04(n)    AB058505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb01d072 wufb01d07 80.57(n)   337190  BC047859.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BEST:CK012963
    CG58851
    CG58851 62(a)3
    61.82(n)1
    65.92(a)1
      30E43
    343141  NM_135477.31  NP_609321.11 
    worm
    (Caenorhabditis elegans)
    Secernentea trap-31 trap-3 51.53(n)
    40.8(a)
      177028  NM_067797.4  NP_500198.1 


    ENSEMBL Gene Tree for SSR3 (if available)
    TreeFam Gene Tree for SSR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSR3 gene

    Find genes that share paralogs with SSR3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SSR3
    PGOHUM00000244765


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSR3 (see all 398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438112921,2
    C--156257433(+) AAAGA-/CCCTCC 1 -- ds50010--------
    rs1898849901,2
    --156257524(+) TTTTCG/TCCATA 1 -- ds50010--------
    rs1405713771,2
    --156257705(+) TACATC/TTGATT 1 -- ds50010--------
    rs1447920461,2
    C--156257982(+) CACAAA/GAATTG 1 -- ut310--------
    rs10466661,2
    C,F,H--156258005(-) AATATG/AGAGAT 1 -- ut3111Minor allele frequency- A:0.12MN NS EA NA WA 924
    rs1386486971,2
    --156258120(+) CCGGGC/TGCGGT 1 -- ut310--------
    rs1418807261,2
    --156258123(+) GGCGCA/GGTGGC 1 -- ut310--------
    rs2014462931,2
    --156258157(+) TGGGA-/GGCCGA 1 -- ut310--------
    rs1833388761,2
    C--156258222(+) ACCCCA/GTCTCT 1 -- ut310--------
    rs130689041,2
    C,F--156258287(+) ctactC/Tggcag 1 -- ut312Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for SSR3 (156257929 - 156272973 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SSR3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv877683CNV Gain21882294
    nsv829764CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSR3
    DNA2.0 Custom Variant and Variant Library Synthesis for SSR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606213    OMIM disorders: --


    Find genes that share disorders with SSR3           About GenesLikeMe


    Export disorders for SSR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSR3 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SSR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPI^. (PubMed id 23660295)1 Chen H.Z....Wu Q. (amp 2013)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. The global gene-expression profiles of U-937 human macrophages treated with Tat peptide and Tat-FITC conjugate. (PubMed id 22632162)1 Lin C.W....Jan M.S. (J Drug Target 2012)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6747 HGNC: 11325 AceView: SSR3 Ensembl:ENSG00000114850 euGenes: HUgn6747
    ECgene: SSR3 Kegg: 6747 H-InvDB: SSR3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSR3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSR3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSR3 gene:
    Search GeneIP for patents involving SSR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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