Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SSR3 Gene

Aliases for SSR3 Gene

  • Signal Sequence Receptor Subunit 3 2 3 5
  • Signal Sequence Receptor, Gamma (Translocon-Associated Protein Gamma) 2 3
  • Signal Sequence Receptor Subunit Gamma 3 4
  • TRAP-Gamma 3 4
  • TRAPG 3 4
  • Translocon-Associated Protein Gamma Subunit 3
  • Translocon-Associated Protein Subunit Gamma 3
  • Translocon-Associated Protein Gamma 2
  • TRAP-Complex Gamma Subunit 3
  • SSR Gamma 3
  • SSR-Gamma 4

External Ids for SSR3 Gene

Previous GeneCards Identifiers for SSR3 Gene

  • GC03M153272
  • GC03M157205
  • GC03M157539
  • GC03M157579
  • GC03M157741
  • GC03M156257
  • GC03M153653

Summaries for SSR3 Gene

Entrez Gene Summary for SSR3 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

GeneCards Summary for SSR3 Gene

SSR3 (Signal Sequence Receptor Subunit 3) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Gene Expression.

UniProtKB/Swiss-Prot for SSR3 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR3 Gene

Genomics for SSR3 Gene

Regulatory Elements for SSR3 Gene

Enhancers for SSR3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G157124 2.2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.4 -576.3 -576265 13.5 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 SIN3A ARID4B DMAP1 FEZF1 KRT18P34 CCNL1 LEKR1 LINC00880 ENSG00000241770 TIPARP SSR3 TIPARP-AS1 GC03M157131
GH03G156673 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -125.3 -125327 14.4 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 LINC00886 LEKR1 CCNL1 SSR3 TIPARP-AS1 TIPARP PIR33904 METTL15P1
GH03G157085 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -533.5 -533510 6.2 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 CCNL1 TIPARP-AS1 TIPARP ENSG00000241770 KRT18P34 SSR3 KCNAB1-AS1 LINC00881 LINC02029
GH03G156482 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +71.2 71161 2.9 HDGF PKNOX1 ATF1 SIN3A ZBTB40 TCF12 GATA2 EGR1 FOS RELB KCNAB1-AS1 SSR3 KCNAB1 TIPARP LEKR1 GC03P156486 GC03M156457
GH03G157119 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 -566.5 -566526 4.9 HNRNPUL1 FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 YY1 LINC00880 SSR3 LEKR1 CCNL1 TIPARP TIPARP-AS1 LINC00881
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSR3 on UCSC Golden Path with GeneCards custom track

Promoters for SSR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000160781 584 2401 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Genomic Location for SSR3 Gene

Chromosome:
3
Start:
156,540,140 bp from pter
End:
156,555,184 bp from pter
Size:
15,045 bases
Orientation:
Minus strand

Genomic View for SSR3 Gene

Genes around SSR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR3 Gene

Proteins for SSR3 Gene

  • Protein details for SSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNL2-SSRG_HUMAN
    Recommended name:
    Translocon-associated protein subunit gamma
    Protein Accession:
    Q9UNL2
    Secondary Accessions:
    • B2R7D0
    • B4E2P2
    • D3DNK5
    • Q549M4

    Protein attributes for SSR3 Gene

    Size:
    185 amino acids
    Molecular mass:
    21080 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

    Alternative splice isoforms for SSR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSR3 Gene

Post-translational modifications for SSR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSR3 Gene

Domains & Families for SSR3 Gene

Protein Domains for SSR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNL2

UniProtKB/Swiss-Prot:

SSRG_HUMAN :
  • Belongs to the TRAP-gamma family.
Family:
  • Belongs to the TRAP-gamma family.
genes like me logo Genes that share domains with SSR3: view

No data available for Gene Families for SSR3 Gene

Function for SSR3 Gene

Molecular function for SSR3 Gene

UniProtKB/Swiss-Prot Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
genes like me logo Genes that share phenotypes with SSR3: view

Animal Models for SSR3 Gene

MGI Knock Outs for SSR3:

Animal Model Products

miRNA for SSR3 Gene

miRTarBase miRNAs that target SSR3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSR3 Gene

Localization for SSR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSR3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSR3: view

Pathways & Interactions for SSR3 Gene

genes like me logo Genes that share pathways with SSR3: view

Pathways by source for SSR3 Gene

Gene Ontology (GO) - Biological Process for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006614 SRP-dependent cotranslational protein targeting to membrane IEA --
genes like me logo Genes that share ontologies with SSR3: view

No data available for SIGNOR curated interactions for SSR3 Gene

Drugs & Compounds for SSR3 Gene

(1) Drugs for SSR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SSR3: view

Transcripts for SSR3 Gene

Unigene Clusters for SSR3 Gene

Signal sequence receptor, gamma (translocon-associated protein gamma):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSR3 Gene

No ASD Table

Relevant External Links for SSR3 Gene

GeneLoc Exon Structure for
SSR3
ECgene alternative splicing isoforms for
SSR3

Expression for SSR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSR3 Gene

This gene is overexpressed in Pancreas (7.2), Bone (7.0), Tlymphocyte (6.4), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSR3 Gene



Protein tissue co-expression partners for SSR3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSR3 Gene:

SSR3

SOURCE GeneReport for Unigene cluster for SSR3 Gene:

Hs.518346

Evidence on tissue expression from TISSUES for SSR3 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Liver(4.4)
  • Kidney(2.7)
  • Heart(2)
genes like me logo Genes that share expression patterns with SSR3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSR3 Gene

Orthologs for SSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSR3 34 35
  • 99.28 (n)
oppossum
(Monodelphis domestica)
Mammalia SSR3 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSR3 34 35
  • 93.69 (n)
rat
(Rattus norvegicus)
Mammalia Ssr3 34
  • 92.25 (n)
mouse
(Mus musculus)
Mammalia Ssr3 34 16 35
  • 91.89 (n)
dog
(Canis familiaris)
Mammalia SSR3 34 35
  • 91.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSR3 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSR3 34 35
  • 82.7 (n)
lizard
(Anolis carolinensis)
Reptilia SSR3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr3 34
  • 79.82 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64286 34
zebrafish
(Danio rerio)
Actinopterygii ssr3 35 35
  • 94 (a)
OneToMany
LOC100535344 34
  • 80.54 (n)
wufb01d07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9105 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008761 34
  • 64.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK01296 36
  • 62 (a)
CG5885 34 35
  • 61.82 (n)
worm
(Caenorhabditis elegans)
Secernentea trap-3 34 35
  • 51.53 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2581 35
  • 51 (a)
OneToOne
Species where no ortholog for SSR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR3 Gene

ENSEMBL:
Gene Tree for SSR3 (if available)
TreeFam:
Gene Tree for SSR3 (if available)

Paralogs for SSR3 Gene

Pseudogenes.org Pseudogenes for SSR3 Gene

genes like me logo Genes that share paralogs with SSR3: view

No data available for Paralogs for SSR3 Gene

Variants for SSR3 Gene

Sequence variations from dbSNP and Humsavar for SSR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000170005 -- 156,545,606(+) TGAAG(A/G)CTAAT intron-variant
rs1000201899 -- 156,556,720(+) GCGGT(A/G)GCTTA upstream-variant-2KB
rs1000254328 -- 156,556,912(+) AAACC(C/T)GGGAG upstream-variant-2KB
rs1000389941 -- 156,544,507(+) CATAT(G/T)GCTCT intron-variant
rs1000457369 -- 156,550,969(+) AGAGT(A/G)GCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSR3 Gene

Variant ID Type Subtype PubMed ID
nsv829764 CNV gain 17160897

Variation tolerance for SSR3 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR3 Gene

Disorders for SSR3 Gene

Relevant External Links for SSR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSR3

No disorders were found for SSR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSR3 Gene

Publications for SSR3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for SSR3 Gene

Sources for SSR3 Gene

Content
Loading form....