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Aliases for SSR3 Gene

Aliases for SSR3 Gene

  • Signal Sequence Receptor, Gamma (Translocon-Associated Protein Gamma) 2 3 5
  • Signal Sequence Receptor Subunit Gamma 3 4
  • TRAP-Gamma 3 4
  • SSR-Gamma 3 4
  • TRAPG 3 4
  • Translocon-Associated Protein Gamma Subunit 3
  • TRAP-Complex Gamma Subunit 3
  • SSR Gamma 3

External Ids for SSR3 Gene

Previous GeneCards Identifiers for SSR3 Gene

  • GC03M153272
  • GC03M157205
  • GC03M157539
  • GC03M157579
  • GC03M157741
  • GC03M156257
  • GC03M153653

Summaries for SSR3 Gene

Entrez Gene Summary for SSR3 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

GeneCards Summary for SSR3 Gene

SSR3 (Signal Sequence Receptor, Gamma (Translocon-Associated Protein Gamma)) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for SSR3 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR3 Gene

Genomics for SSR3 Gene

Regulatory Elements for SSR3 Gene

Promoters for SSR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSR3 Gene

Chromosome:
3
Start:
156,540,140 bp from pter
End:
156,555,184 bp from pter
Size:
15,045 bases
Orientation:
Minus strand

Genomic View for SSR3 Gene

Genes around SSR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR3 Gene

Proteins for SSR3 Gene

  • Protein details for SSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UNL2-SSRG_HUMAN
    Recommended name:
    Translocon-associated protein subunit gamma
    Protein Accession:
    Q9UNL2
    Secondary Accessions:
    • B2R7D0
    • B4E2P2
    • D3DNK5
    • Q549M4

    Protein attributes for SSR3 Gene

    Size:
    185 amino acids
    Molecular mass:
    21080 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

    Alternative splice isoforms for SSR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSR3 Gene

Proteomics data for SSR3 Gene at MOPED

Post-translational modifications for SSR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSR3 Gene

Domains & Families for SSR3 Gene

Protein Domains for SSR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UNL2

UniProtKB/Swiss-Prot:

SSRG_HUMAN :
  • Belongs to the TRAP-gamma family.
Family:
  • Belongs to the TRAP-gamma family.
genes like me logo Genes that share domains with SSR3: view

No data available for Gene Families for SSR3 Gene

Function for SSR3 Gene

Molecular function for SSR3 Gene

UniProtKB/Swiss-Prot Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
genes like me logo Genes that share phenotypes with SSR3: view

Animal Models for SSR3 Gene

MGI Knock Outs for SSR3:

Animal Model Products

miRNA for SSR3 Gene

miRTarBase miRNAs that target SSR3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSR3 Gene

Localization for SSR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSR3 Gene COMPARTMENTS Subcellular localization image for SSR3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SSR3: view

Pathways & Interactions for SSR3 Gene

genes like me logo Genes that share pathways with SSR3: view

Pathways by source for SSR3 Gene

Gene Ontology (GO) - Biological Process for SSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane IEA --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SSR3: view

No data available for SIGNOR curated interactions for SSR3 Gene

Drugs & Compounds for SSR3 Gene

(1) Drugs for SSR3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SSR3: view

Transcripts for SSR3 Gene

Unigene Clusters for SSR3 Gene

Signal sequence receptor, gamma (translocon-associated protein gamma):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSR3 Gene

No ASD Table

Relevant External Links for SSR3 Gene

GeneLoc Exon Structure for
SSR3
ECgene alternative splicing isoforms for
SSR3

Expression for SSR3 Gene

mRNA expression in normal human tissues for SSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSR3 Gene

This gene is overexpressed in Pancreas (7.2), Bone (7.0), Tlymphocyte (6.4), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSR3 Gene



SOURCE GeneReport for Unigene cluster for SSR3 Gene Hs.518346

genes like me logo Genes that share expression patterns with SSR3: view

Protein tissue co-expression partners for SSR3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSR3 Gene

Orthologs for SSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSR3 36
  • 100 (a)
OneToOne
SSR3 35
  • 99.28 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SSR3 35
  • 93.69 (n)
  • 98.38 (a)
SSR3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSR3 36
  • 99 (a)
OneToOne
SSR3 35
  • 91.35 (n)
  • 98.92 (a)
mouse
(Mus musculus)
Mammalia Ssr3 16
Ssr3 36
  • 99 (a)
OneToOne
Ssr3 35
  • 91.89 (n)
  • 98.92 (a)
oppossum
(Monodelphis domestica)
Mammalia SSR3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSR3 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssr3 35
  • 92.25 (n)
  • 98.92 (a)
chicken
(Gallus gallus)
Aves SSR3 35
  • 82.7 (n)
  • 95.68 (a)
SSR3 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSR3 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64286 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr3 35
  • 79.82 (n)
  • 95.14 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9105 35
zebrafish
(Danio rerio)
Actinopterygii ssr3 36
  • 94 (a)
OneToMany
ssr3 36
  • 94 (a)
OneToMany
LOC100535344 35
  • 80.54 (n)
  • 94.59 (a)
wufb01d07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008761 35
  • 64.12 (n)
  • 65.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta BEST:CK01296 37
  • 62 (a)
CG5885 35
  • 61.82 (n)
  • 65.92 (a)
CG5885 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trap-3 35
  • 51.53 (n)
  • 40.8 (a)
trap-3 36
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2581 36
  • 51 (a)
OneToOne
Species with no ortholog for SSR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR3 Gene

ENSEMBL:
Gene Tree for SSR3 (if available)
TreeFam:
Gene Tree for SSR3 (if available)

Paralogs for SSR3 Gene

Pseudogenes.org Pseudogenes for SSR3 Gene

genes like me logo Genes that share paralogs with SSR3: view

No data available for Paralogs for SSR3 Gene

Variants for SSR3 Gene

Sequence variations from dbSNP and Humsavar for SSR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs8665 -- 156,541,696(-) AGTCA(C/T)ATATC utr-variant-3-prime
rs9296 -- 156,548,985(-) AGGGA(A/G)GATGC reference, synonymous-codon
rs1510277 -- 156,542,456(-) AATCA(C/T)TGTTT utr-variant-3-prime
rs2292337 -- 156,553,806(+) GGAAG(A/G)GTACA intron-variant
rs2292338 -- 156,553,819(+) AAGAA(A/G)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSR3 Gene

Variant ID Type Subtype PubMed ID
nsv829764 CNV Gain 17160897
nsv877683 CNV Gain 21882294

Variation tolerance for SSR3 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSR3 Gene

HapMap Linkage Disequilibrium report
SSR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR3 Gene

Disorders for SSR3 Gene

Relevant External Links for SSR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSR3

No disorders were found for SSR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSR3 Gene

Publications for SSR3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPI^. (PMID: 23660295) Chen H.Z. … Wu Q. (Int. J. Biochem. Cell Biol. 2013) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for SSR3 Gene

Sources for SSR3 Gene

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