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Aliases for SSR2 Gene

Aliases for SSR2 Gene

  • Signal Sequence Receptor Subunit 2 2 3 5
  • Signal Sequence Receptor, Beta (Translocon-Associated Protein Beta) 2 3
  • Signal Sequence Receptor Subunit Beta 3 4
  • Translocon-Associated Protein Beta 2 3
  • TRAP-BETA 3 4
  • SSR-Beta 3 4
  • TRAPB 3 4
  • Translocon-Associated Protein Subunit Beta 3
  • HSD25 3
  • TLAP 3

External Ids for SSR2 Gene

Previous GeneCards Identifiers for SSR2 Gene

  • GC01M153847
  • GC01M151744
  • GC01M152756
  • GC01M153195
  • GC01M152791
  • GC01M154246
  • GC01M155979
  • GC01M127340
  • GC01M155983
  • GC01M155989

Summaries for SSR2 Gene

Entrez Gene Summary for SSR2 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSR2 Gene

SSR2 (Signal Sequence Receptor Subunit 2) is a Protein Coding gene. Diseases associated with SSR2 include Calcaneonavicular Coalition. Among its related pathways are Protein processing in endoplasmic reticulum and Viral mRNA Translation.

UniProtKB/Swiss-Prot for SSR2 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Gene Wiki entry for SSR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR2 Gene

Genomics for SSR2 Gene

Regulatory Elements for SSR2 Gene

Enhancers for SSR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156486 1.9 FANTOM5 Ensembl ENCODE 30.1 -477.9 -477873 25.4 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 RRNAD1 KIAA0907 LOC246784 ENSG00000271267 SSR2 GLMP MEF2D ENSG00000229961 DAP3P1 TSACC
GH01F156456 1.6 FANTOM5 ENCODE 20.9 -436.4 -436386 2.7 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KIAA0907 RRNAD1 ENSG00000271267 LOC246784 SSR2 ENSG00000229961 DAP3P1 TSACC ARHGEF2 C1orf61
GH01F156740 1.6 FANTOM5 ENCODE 20.9 -725.9 -725872 13.6 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 RRNAD1 KIAA0907 LOC246784 SSR2 PEAR1 HDGF ETV3 LOC105371454 GLMP RIT1
GH01F155242 1.2 ENCODE 20.9 +776.7 776749 2.9 CREB3L1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 MSTO2P RUSC1-AS1 THBS3 ASH1L PYGO2 LOC101928120 KRTCAP2 GBA
GH01F156656 2.3 VISTA FANTOM5 Ensembl ENCODE 10.9 -643.3 -643268 15.3 CREB3L1 MLX ZFP64 DMAP1 ZNF416 ZNF143 ZNF263 MCM3 SP3 SSRP1 MSTO2P ENSG00000229961 ENSG00000233712 KIAA0907 TSACC RRNAD1 ENSG00000272405 SSR2 GLMP LOC246784
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSR2 on UCSC Golden Path with GeneCards custom track

Promoters for SSR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166900 291 1401 HDGF PKNOX1 ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ETS1

Genomic Location for SSR2 Gene

Chromosome:
1
Start:
156,009,048 bp from pter
End:
156,020,991 bp from pter
Size:
11,944 bases
Orientation:
Minus strand

Genomic View for SSR2 Gene

Genes around SSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR2 Gene

Proteins for SSR2 Gene

  • Protein details for SSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43308-SSRB_HUMAN
    Recommended name:
    Translocon-associated protein subunit beta
    Protein Accession:
    P43308
    Secondary Accessions:
    • B2R9K9
    • D3DVA7
    • Q53HI0
    • Q5VY95
    • Q5VY96
    • Q6IB31
    • Q9BWE4

    Protein attributes for SSR2 Gene

    Size:
    183 amino acids
    Molecular mass:
    20135 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING.
    SequenceCaution:
    • Sequence=CAH72631.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72632.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SSR2 Gene

Post-translational modifications for SSR2 Gene

  • Ubiquitination at Lys 27
  • Glycosylation at Asn 88 and Asn 104
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SSR2 Gene

Domains & Families for SSR2 Gene

Protein Domains for SSR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43308

UniProtKB/Swiss-Prot:

SSRB_HUMAN :
  • Belongs to the TRAP-beta family.
Family:
  • Belongs to the TRAP-beta family.
genes like me logo Genes that share domains with SSR2: view

No data available for Gene Families for SSR2 Gene

Function for SSR2 Gene

Molecular function for SSR2 Gene

GENATLAS Biochemistry:
signal sequence receptor,beta (22kDa) involved in protein translocation process
UniProtKB/Swiss-Prot Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
genes like me logo Genes that share phenotypes with SSR2: view

Animal Models for SSR2 Gene

MGI Knock Outs for SSR2:
  • Ssr2 tm1b(EUCOMM)Wtsi

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSR2 Gene

Localization for SSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSR2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3

Gene Ontology (GO) - Cellular Components for SSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 7789174
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSR2: view

Pathways & Interactions for SSR2 Gene

genes like me logo Genes that share pathways with SSR2: view

Pathways by source for SSR2 Gene

Gene Ontology (GO) - Biological Process for SSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 7789174
genes like me logo Genes that share ontologies with SSR2: view

No data available for SIGNOR curated interactions for SSR2 Gene

Drugs & Compounds for SSR2 Gene

(1) Drugs for SSR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SSR2: view

Transcripts for SSR2 Gene

Unigene Clusters for SSR2 Gene

Signal sequence receptor, beta (translocon-associated protein beta):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - - - -
SP12: - - - - - -
SP13: - - -

Relevant External Links for SSR2 Gene

GeneLoc Exon Structure for
SSR2
ECgene alternative splicing isoforms for
SSR2

Expression for SSR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSR2 Gene

This gene is overexpressed in Ovary (27.3), Testis (13.6), Pancreas (12.2), Hair follicle (8.7), and Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSR2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SSR2 Gene:

SSR2

SOURCE GeneReport for Unigene cluster for SSR2 Gene:

Hs.74564
genes like me logo Genes that share expression patterns with SSR2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SSR2 Gene

Orthologs for SSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSR2 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia SSR2 34 35
  • 93.26 (n)
oppossum
(Monodelphis domestica)
Mammalia SSR2 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSR2 34 35
  • 91.44 (n)
rat
(Rattus norvegicus)
Mammalia Ssr2 34
  • 89.62 (n)
mouse
(Mus musculus)
Mammalia Ssr2 34 16 35
  • 89.25 (n)
chicken
(Gallus gallus)
Aves SSR2 34 35
  • 80.15 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr2 34
  • 77.6 (n)
Str.3091 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53499 34
zebrafish
(Danio rerio)
Actinopterygii ssr2 34 35
  • 75.77 (n)
Dr.1209 34
fruit fly
(Drosophila melanogaster)
Insecta SsRbeta 34 35
  • 55.81 (n)
SsRbgr 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005861 34
  • 55.3 (n)
worm
(Caenorhabditis elegans)
Secernentea trap-2 34 35
  • 48.04 (n)
K08F4.3 35
  • 30 (a)
OneToMany
Species where no ortholog for SSR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR2 Gene

ENSEMBL:
Gene Tree for SSR2 (if available)
TreeFam:
Gene Tree for SSR2 (if available)

Paralogs for SSR2 Gene

(1) SIMAP similar genes for SSR2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SSR2: view

No data available for Paralogs for SSR2 Gene

Variants for SSR2 Gene

Sequence variations from dbSNP and Humsavar for SSR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1049286 -- 156,009,466(-) CAGAC(G/T)CCAAA utr-variant-3-prime
rs10908486 -- 156,008,753(+) GATGA(C/G)AATAG downstream-variant-500B
rs10908487 -- 156,012,957(+) GGAAA(A/C)AGAAA intron-variant
rs111342657 -- 156,015,280(+) GCGGG(C/T)GGATT intron-variant
rs111397922 -- 156,018,651(+) TTGCA(A/G)TGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSR2 Gene

Variant ID Type Subtype PubMed ID
nsv509513 CNV insertion 20534489

Variation tolerance for SSR2 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR2 Gene

Disorders for SSR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
calcaneonavicular coalition
  • multiple synostosis syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SSR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSR2

Genetic Association Database (GAD)
SSR2
Human Genome Epidemiology (HuGE) Navigator
SSR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSR2
genes like me logo Genes that share disorders with SSR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSR2 Gene

Publications for SSR2 Gene

  1. Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). (PMID: 7789174) Chinen K. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SSR2 Gene

Sources for SSR2 Gene

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