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Aliases for SSR2 Gene

Aliases for SSR2 Gene

  • Signal Sequence Receptor, Beta (Translocon-Associated Protein Beta) 2 3 5
  • Signal Sequence Receptor Subunit Beta 3 4
  • TRAP-BETA 3 4
  • SSR-Beta 3 4
  • TRAPB 3 4
  • Translocon-Associated Protein Beta 3
  • HSD25 3
  • TLAP 3

External Ids for SSR2 Gene

Previous GeneCards Identifiers for SSR2 Gene

  • GC01M153847
  • GC01M151744
  • GC01M152756
  • GC01M153195
  • GC01M152791
  • GC01M154246
  • GC01M155979
  • GC01M127340
  • GC01M155983
  • GC01M155989

Summaries for SSR2 Gene

Entrez Gene Summary for SSR2 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. [provided by RefSeq, Jul 2008]

GeneCards Summary for SSR2 Gene

SSR2 (Signal Sequence Receptor, Beta (Translocon-Associated Protein Beta)) is a Protein Coding gene. Diseases associated with SSR2 include Calcaneonavicular Coalition. Among its related pathways are Gene Expression and Viral mRNA Translation.

UniProtKB/Swiss-Prot for SSR2 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Gene Wiki entry for SSR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR2 Gene

Genomics for SSR2 Gene

Regulatory Elements for SSR2 Gene

Enhancers for SSR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSR2 on UCSC Golden Path with GeneCards custom track

Promoters for SSR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSR2 Gene

Chromosome:
1
Start:
156,009,048 bp from pter
End:
156,020,991 bp from pter
Size:
11,944 bases
Orientation:
Minus strand

Genomic View for SSR2 Gene

Genes around SSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR2 Gene

Proteins for SSR2 Gene

  • Protein details for SSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43308-SSRB_HUMAN
    Recommended name:
    Translocon-associated protein subunit beta
    Protein Accession:
    P43308
    Secondary Accessions:
    • B2R9K9
    • D3DVA7
    • Q53HI0
    • Q5VY95
    • Q5VY96
    • Q6IB31
    • Q9BWE4

    Protein attributes for SSR2 Gene

    Size:
    183 amino acids
    Molecular mass:
    20135 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING.
    SequenceCaution:
    • Sequence=CAH72631.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72632.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SSR2 Gene

Proteomics data for SSR2 Gene at MOPED

Post-translational modifications for SSR2 Gene

  • Ubiquitination at Lys 27
  • Glycosylation at Asn 88 and Asn 104
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SSR2 Gene

Domains & Families for SSR2 Gene

Protein Domains for SSR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43308

UniProtKB/Swiss-Prot:

SSRB_HUMAN :
  • Belongs to the TRAP-beta family.
Family:
  • Belongs to the TRAP-beta family.
genes like me logo Genes that share domains with SSR2: view

No data available for Gene Families for SSR2 Gene

Function for SSR2 Gene

Molecular function for SSR2 Gene

GENATLAS Biochemistry:
signal sequence receptor,beta (22kDa) involved in protein translocation process
UniProtKB/Swiss-Prot Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
genes like me logo Genes that share phenotypes with SSR2: view

Animal Models for SSR2 Gene

MGI Knock Outs for SSR2:
  • Ssr2 tm1b(EUCOMM)Wtsi

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSR2 Gene

Localization for SSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR2 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSR2 Gene COMPARTMENTS Subcellular localization image for SSR2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3

Gene Ontology (GO) - Cellular Components for SSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with SSR2: view

Pathways & Interactions for SSR2 Gene

genes like me logo Genes that share pathways with SSR2: view

Pathways by source for SSR2 Gene

Gene Ontology (GO) - Biological Process for SSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 7789174
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SSR2: view

No data available for SIGNOR curated interactions for SSR2 Gene

Drugs & Compounds for SSR2 Gene

(1) Drugs for SSR2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SSR2: view

Transcripts for SSR2 Gene

Unigene Clusters for SSR2 Gene

Signal sequence receptor, beta (translocon-associated protein beta):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - - - -
SP10: - - -
SP11: - - - - - - - - -
SP12: - - - - - -
SP13: - - -

Relevant External Links for SSR2 Gene

GeneLoc Exon Structure for
SSR2
ECgene alternative splicing isoforms for
SSR2

Expression for SSR2 Gene

mRNA expression in normal human tissues for SSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSR2 Gene

This gene is overexpressed in Ovary (27.3), Testis (13.6), Pancreas (12.2), Hair follicle (8.7), and Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSR2 Gene



SOURCE GeneReport for Unigene cluster for SSR2 Gene Hs.74564

genes like me logo Genes that share expression patterns with SSR2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SSR2 Gene

Orthologs for SSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSR2 35
  • 93.26 (n)
  • 97.27 (a)
SSR2 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSR2 35
  • 91.44 (n)
  • 95.63 (a)
SSR2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssr2 35
  • 89.25 (n)
  • 97.27 (a)
Ssr2 16
Ssr2 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSR2 35
  • 100 (n)
  • 100 (a)
SSR2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssr2 35
  • 89.62 (n)
  • 96.72 (a)
oppossum
(Monodelphis domestica)
Mammalia SSR2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSR2 35
  • 80.15 (n)
  • 91.26 (a)
SSR2 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr2 35
  • 77.6 (n)
  • 87.43 (a)
Str.3091 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53499 35
zebrafish
(Danio rerio)
Actinopterygii Dr.1209 35
ssr2 35
  • 75.77 (n)
  • 86.34 (a)
ssr2 36
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SsRbgr 37
  • 48 (a)
SsRbeta 35
  • 55.81 (n)
  • 49.44 (a)
SsRbeta 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005861 35
  • 55.3 (n)
  • 50.57 (a)
worm
(Caenorhabditis elegans)
Secernentea trap-2 35
  • 48.04 (n)
  • 39.66 (a)
K08F4.3 36
  • 30 (a)
OneToMany
trap-2 36
  • 37 (a)
OneToMany
Species with no ortholog for SSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR2 Gene

ENSEMBL:
Gene Tree for SSR2 (if available)
TreeFam:
Gene Tree for SSR2 (if available)

Paralogs for SSR2 Gene

(1) SIMAP similar genes for SSR2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SSR2: view

No data available for Paralogs for SSR2 Gene

Variants for SSR2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SSR2 Gene

Variant ID Type Subtype PubMed ID
nsv509513 CNV Insertion 20534489

Variation tolerance for SSR2 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for SSR2 Gene

Disorders for SSR2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSR2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
calcaneonavicular coalition
  • multiple synostosis syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SSR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSR2

Genetic Association Database (GAD)
SSR2
Human Genome Epidemiology (HuGE) Navigator
SSR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSR2
genes like me logo Genes that share disorders with SSR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSR2 Gene

Publications for SSR2 Gene

  1. Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). (PMID: 7789174) Chinen K. … Nakamura Y. (Cytogenet. Cell Genet. 1995) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation. (PMID: 18293417) Sikorska M. … Walker P.R. (J. Neurosci. Res. 2008) 3

Products for SSR2 Gene

Sources for SSR2 Gene

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