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SSR2 Gene

protein-coding   GIFtS: 60
GCID: GC01M155989

Signal Sequence Receptor, Beta (Translocon-Associated Protein...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Signal Sequence Receptor, Beta (Translocon-Associated Protein Beta)1 2     TRAP-BETA2
Signal Sequence Receptor Subunit Beta2 3     Translocon-Associated Protein Beta2
SSR-beta2 3     Translocon-Associated Protein Subunit Beta2
TRAPB2 3     TRAP-beta3
TLAP2     

External Ids:    HGNC: 113241   Entrez Gene: 67462   Ensembl: ENSG000001634797   OMIM: 6008675   UniProtKB: P433083   
ORGUL members:         

Export aliases for SSR2 gene to outside databases

Previous GC identifers: GC01M153847 GC01M151744 GC01M152756 GC01M153195 GC01M152791 GC01M154246 GC01M155979 GC01M127340 GC01M155983


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSR2 Gene:
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with
protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or
SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to
chromosome bands 1q21-q23. (provided by RefSeq, Jul 2008)

GeneCards Summary for SSR2 Gene:
SSR2 (signal sequence receptor, beta (translocon-associated protein beta)) is a protein-coding gene. Diseases associated with SSR2 include calcaneonavicular coalition, and osteosarcoma.

UniProtKB/Swiss-Prot: SSRB_HUMAN, P43308
Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
regulate the retention of ER resident proteins

Gene Wiki entry for SSR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSR2 gene promoter:
         AML1a   p300   GCNF   XBP-1   GATA-1   AREB6   GCNF-1   GCNF-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSR2 promoter sequence
   Search Chromatin IP Primers for SSR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q23   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21-q23

SSR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSR2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155989:  view genomic region     (about GC identifiers)

Start:
155,978,839 bp from pter      End:
155,990,758 bp from pter
Size:
11,920 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SSRB_HUMAN, P43308 (See protein sequence)
Recommended Name: Translocon-associated protein subunit beta precursor  
Size: 183 amino acids; 20135 Da
Subunit: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING
Sequence caution: Sequence=CAH72631.1; Type=Erroneous gene model prediction; Sequence=CAH72632.1; Type=Erroneous
gene model prediction;
Secondary accessions: B2R9K9 D3DVA7 Q53HI0 Q5VY95 Q5VY96 Q6IB31 Q9BWE4

Explore the universe of human proteins at neXtProt for SSR2: NX_P43308

Explore proteomics data for SSR2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys27
  • Glycosylation2 at Asn88, Asn104
  • Modification sites at PhosphoSitePlus

  • See SSR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003136.1  
    ENSEMBL proteins: 
     ENSP00000295702   ENSP00000434870   ENSP00000436201   ENSP00000432831   ENSP00000434306  
     ENSP00000431366   ENSP00000436228   ENSP00000437239   ENSP00000435692   ENSP00000434532  
    Reactome Protein details: P43308

    SSR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SSR2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SSR2
    GenScript Custom Purified and Recombinant Proteins Services for SSR2
    Novus Biologicals SSR2 Proteins
    Novus Biologicals SSR2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SSR2
    Browse Proteins at Cloud-Clone Corp.

    SSR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SSR2
    Novus Biologicals SSR2 Antibodies
    Abcam antibodies for SSR2
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for SSR2
    LSBio Antibodies in human, mouse, rat for SSR2

    SSR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SSR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SSR2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008856 TRAP_beta

    Graphical View of Domain Structure for InterPro Entry P43308

    ProtoNet protein and cluster: P43308

    UniProtKB/Swiss-Prot: SSRB_HUMAN, P43308
    Similarity: Belongs to the TRAP-beta family


    SSR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSRB_HUMAN, P43308
    Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
    regulate the retention of ER resident proteins

         Genatlas biochemistry entry for SSR2:
    signal sequence receptor,beta (22kDa) involved in protein translocation process

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SSR2:
    hsa-mir-345-5p (MIRT042734), hsa-mir-149-5p (MIRT045638), hsa-mir-186-5p (MIRT045273), hsa-mir-615-3p (MIRT040270), hsa-mir-339-5p (MIRT042799)

    Block miRNA regulation of human, mouse, rat SSR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSR2 (see all 11):
    hsa-miR-875-3p hsa-miR-876-5p hsa-miR-578 hsa-miR-619 hsa-miR-4294 hsa-miR-3167 hsa-miR-135b hsa-miR-4309
    SwitchGear 3'UTR luciferase reporter plasmidSSR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SSR2
    Predesigned siRNA for gene silencing in human, mouse, rat SSR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SSR2

    Clone
    Products:
         
    OriGene clones in human, mouse for SSR2 (see all 6)
    OriGene ORF clones in mouse, rat for SSR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR2 (NM_003145)
    Sino Biological Human cDNA Clone for SSR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SSR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SSR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSRB_HUMAN, P43308: Endoplasmic reticulum membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS7789174
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    SSR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    2Gene Expression
    Gene Expression0.40
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SSR2
        SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SSR2):
        Protein processing in endoplasmic reticulum


    SSR2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSR2
    Interactions:

        Search GeneGlobe Interaction Network for SSR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSR2 (P433083 ENSP000002957024) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SEC61BP604683, ENSP000002236414I2D: score=1 STRING: ENSP00000223641
    SRPRP082403, ENSP000003280234I2D: score=3 STRING: ENSP00000328023
    ATP6V0CP274493, ENSP000003297574I2D: score=1 STRING: ENSP00000329757
    TMEM173Q86WV63I2D: score=1 
    FAUENSP000002792594STRING: ENSP00000279259
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane TAS7789174
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0010467gene expression TAS--
    GO:0044267cellular protein metabolic process TAS--

    SSR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSR2 (SSRB)

    1 HMDB Compound for SSR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SSR2 gene: 
    NM_003145.3  

    Unigene Cluster for SSR2:

    Signal sequence receptor, beta (translocon-associated protein beta)
    Hs.74564  [show with all ESTs]
    Unigene Representative Sequence: BF697274
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295702(uc001fmx.3) ENST00000472467(uc001fmv.3) ENST00000488179
    ENST00000529008 ENST00000496742 ENST00000484320 ENST00000532074 ENST00000480176
    ENST00000473699 ENST00000480567 ENST00000531790 ENST00000368311(uc010pgw.2)
    ENST00000472898 ENST00000531917 ENST00000474377 ENST00000466905 ENST00000526212
    ENST00000467041
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SSR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSR2 (see all 11):
    hsa-miR-875-3p hsa-miR-876-5p hsa-miR-578 hsa-miR-619 hsa-miR-4294 hsa-miR-3167 hsa-miR-135b hsa-miR-4309
    SwitchGear 3'UTR luciferase reporter plasmidSSR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SSR2
    Predesigned siRNA for gene silencing in human, mouse, rat SSR2
    Clone
    Products:
         
    OriGene clones in human, mouse for SSR2 (see all 6)
    OriGene ORF clones in mouse, rat for SSR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR2 (NM_003145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SSR2
    OriGene qSTAR qPCR primer pairs in human, mouse for SSR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSR2
      QuantiTect SYBR Green Assays in human, mouse, rat SSR2
      QuantiFast Probe-based Assays in human, mouse, rat SSR2

    Additional mRNA sequence: 

    AK222600.1 AK300678.1 AK313821.1 AY251536.1 BC000341.2 CR456973.1 D37991.1 X74104.1 

    Selected DOTS entries (see all 32):

    DT.95157433  DT.100838444  DT.100888968  DT.95157372  DT.100888972  DT.91780671  DT.101985323  DT.95157441 
    DT.95157448  DT.95157456  DT.121391552  DT.121391563  DT.100888977  DT.121391618  DT.100039458  DT.100833029 
    DT.102833909  DT.121391603  DT.100800377  DT.100888962  DT.100888976  DT.121391555  DT.121391556  DT.121391558 

    Selected AceView cDNA sequences (see all 926):

    D37991 AL540530 CR590937 AA358654 CA416477 CA487779 BF219703 BM851147 
    BQ684114 CA417789 BU630040 BM985036 CR613556 AL558166 BI826499 BQ232907 
    BX360998 BU839204 BM782095 BQ683624 BQ229756 AA299305 BF733129 AA999703 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSR2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
    SP1:                    -                       -     -           -     -           -     -                                                   
    SP2:                                            -     -           -     -           -     -                                                   
    SP3:                    -                       -     -           -     -                                                                     
    SP4:                    -                                   -     -     -           -     -                                                   
    SP5:                    -                       -     -           -                                                                           


    ECgene alternative splicing isoforms for SSR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCTTCCCT
    SSR2 Expression
    About this image


    SSR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    SSR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74564
        Custom PCR Arrays for SSR2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SSR2
    OriGene qSTAR qPCR primer pairs in human, mouse for SSR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSR2
    QuantiTect SYBR Green Assays in human, mouse, rat SSR2
    QuantiFast Probe-based Assays in human, mouse, rat SSR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SSR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssr21 , 5 signal sequence receptor, beta1, 5 89.25(n)1
    97.27(a)1
      3 (38.88 cM)5
    662561  NM_025448.31  NP_079724.11 
     885796715 
    chicken
    (Gallus gallus)
    Aves SSR21 signal sequence receptor, beta (translocon-associated more 80.15(n)
    91.26(a)
      425656  NM_001006561.1  NP_001006561.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC534992 similar to signal sequence receptor, beta 80.9(n)    AF346565.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.12092 Danio rerio translocon-associated protein beta mRNA, more 78.29(n)    AF364084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SsR&bgr;3
    SsRbeta1
    protein-ER retention signal sequence
    receptor3
    Signal sequence receptor beta1
    48(a)3
    55.81(n)1
    49.44(a)1
      397681  NM_079379.31  NP_524103.21 
    worm
    (Caenorhabditis elegans)
    Secernentea trap-21 trap-2 48.04(n)
    39.66(a)
      180422  NM_075749.5  NP_508150.1 


    ENSEMBL Gene Tree for SSR2 (if available)
    TreeFam Gene Tree for SSR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSR2 gene
    1 SIMAP similar gene for SSR2 using alignment to 8 protein entries:     SSRB_HUMAN (see all proteins):
    DKFZp686F19123

    SSR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSR2 (see all 269)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs750795251,2
    C,F--155978459(+) CAGAGC/TGAGAT 1 -- ds50012Minor allele frequency- T:0.05NA 122
    rs592798321,2
    C--155978472(+) AAAAA-/A/AAA 
            
    CCCAC
    2 -- ds5001 cds10--------
    rs109084861,2
    C,F,A,H--155978544(+) GATGAC/GAATAG 1 -- ds500118Minor allele frequency- G:0.36NS EA NA WA CSA 933
    rs1852247751,2
    --155978569(+) ACCATC/GTTTCC 1 -- ds50010--------
    rs9151781,2
    C,F,O,A,H--155978725(-) TGGGCA/GGGTCC 1 -- ds500121Minor allele frequency- G:0.44NA EA NS WA 4167
    rs1491991131,2
    --155978755(+) AGAACC/TCAGCT 1 -- ds50010--------
    rs1896965521,2
    C--155978804(+) AATCAC/TCTGTG 1 -- ds50010--------
    rs1833828971,2
    --155978933(+) AGCTTC/TCATTT 1 -- ut310--------
    rs412649971,2
    C--155978971(+) AGGCAA/GGGGAT 1 -- ut310--------
    rs412649991,2
    C,F--155978981(+) TAGGGG/ATGGTG 1 -- ut311Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for SSR2 (155978839 - 155990758 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SSR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSR2
    DNA2.0 Custom Variant and Variant Library Synthesis for SSR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600867    OMIM disorders: --

    6 diseases for SSR2:    
    About MalaCards
    calcaneonavicular coalition    osteosarcoma    pancreatic cancer    pancreatitis
    melanoma    malaria


    SSR2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SSR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 8751588 (1), 12601018 (1)

    Genetic Association Database (GAD): SSR2
    Human Genome Epidemiology (HuGE) Navigator: SSR2 (1 document)

    Export disorders for SSR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSR2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with SSR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). (PubMed id 7789174)1, 2, 3, 9 Chinen K.... Nakamura Y. (Cytogenet. Cell Genet. 1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    7. Cloning and sequence analysis of the beta subunit of the human translocon-associated protein. (PubMed id 8286409)1, 2 Bodescot M. and Brison O. (Biochim. Biophys. Acta 1994)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6746 HGNC: 11324 AceView: SSR2 Ensembl:ENSG00000163479 euGenes: HUgn6746
    ECgene: SSR2 Kegg: 6746 H-InvDB: SSR2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SSR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSR2 gene:
    Search GeneIP for patents involving SSR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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