Aliases for SSR1 Gene
External Ids for SSR1 Gene
Previous GeneCards Identifiers for SSR1 Gene
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
GeneCards Summary for SSR1 Gene
SSR1 (Signal Sequence Receptor, Alpha) is a Protein Coding gene. Diseases associated with SSR1 include amyotrophic lateral sclerosis 1. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR).
UniProtKB/Swiss-Prot for SSR1 Gene
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins