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Aliases for SSR1 Gene

Aliases for SSR1 Gene

  • Signal Sequence Receptor, Alpha 2 3
  • Signal Sequence Receptor Subunit Alpha 3 4
  • TRAP-Alpha 3 4
  • SSR-Alpha 3 4
  • TRAPA 3 4
  • Translocon-Associated Protein Alpha Subunit 3
  • Translocon-Associated Protein Subunit Alpha 3
  • Translocon-Associated Protein Alpha 2
  • SSR Alpha Subunit 3
  • TRAP Alpha 3

External Ids for SSR1 Gene

Previous GeneCards Identifiers for SSR1 Gene

  • GC06M007272
  • GC06M007232
  • GC06M007157

Summaries for SSR1 Gene

Entrez Gene Summary for SSR1 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for SSR1 Gene

SSR1 (Signal Sequence Receptor, Alpha) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response.

UniProtKB/Swiss-Prot for SSR1 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins

Gene Wiki entry for SSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR1 Gene

Genomics for SSR1 Gene

Regulatory Elements for SSR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSR1 Gene

Start:
7,268,306 bp from pter
End:
7,347,446 bp from pter
Size:
79,141 bases
Orientation:
Minus strand

Genomic View for SSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR1 Gene

Proteins for SSR1 Gene

  • Protein details for SSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43307-SSRA_HUMAN
    Recommended name:
    Translocon-associated protein subunit alpha
    Protein Accession:
    P43307
    Secondary Accessions:
    • A8K685
    • Q53GX2
    • Q53H19
    • Q5TAM3
    • Q6IB43
    • Q8NBH9
    • Q96IA2
    • Q9TNQ8
    • Q9UN49

    Protein attributes for SSR1 Gene

    Size:
    286 amino acids
    Molecular mass:
    32235 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
    Miscellaneous:
    • Seems to bind calcium
    SequenceCaution:
    • Sequence=CAI16444.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSR1 Gene

Proteomics data for SSR1 Gene at MOPED

Post-translational modifications for SSR1 Gene

  • Ubiquitination at Lys102
  • Glycosylation at Asn136 and Asn191
  • Modification sites at PhosphoSitePlus

Other Protein References for SSR1 Gene

Antibody Products

No data available for DME Specific Peptides for SSR1 Gene

Domains for SSR1 Gene

Protein Domains for SSR1 Gene

Suggested Antigen Peptide Sequences for SSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43307

UniProtKB/Swiss-Prot:

SSRA_HUMAN :
  • P43307
Domain:
  • Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged
Family:
  • Belongs to the TRAP-alpha family.
genes like me logo Genes that share domains with SSR1: view

No data available for Gene Families for SSR1 Gene

Function for SSR1 Gene

Molecular function for SSR1 Gene

UniProtKB/Swiss-Prot Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins

Gene Ontology (GO) - Molecular Function for SSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17380188
genes like me logo Genes that share ontologies with SSR1: view

Phenotypes for SSR1 Gene

genes like me logo Genes that share phenotypes with SSR1: view

Animal Model Products

CRISPR Products

miRNA for SSR1 Gene

miRTarBase miRNAs that target SSR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SSR1 Gene

Localization for SSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSR1 Gene COMPARTMENTS Subcellular localization image for SSR1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
golgi apparatus 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSR1: view

Pathways for SSR1 Gene

genes like me logo Genes that share pathways with SSR1: view

Gene Ontology (GO) - Biological Process for SSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane TAS 8050590
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0008284 positive regulation of cell proliferation TAS 10437777
genes like me logo Genes that share ontologies with SSR1: view

Compounds for SSR1 Gene

(1) HMDB Compounds for SSR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with SSR1: view

Transcripts for SSR1 Gene

Unigene Clusters for SSR1 Gene

Signal sequence receptor, alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for SSR1 Gene

GeneLoc Exon Structure for
SSR1
ECgene alternative splicing isoforms for
SSR1

Expression for SSR1 Gene

mRNA expression in normal human tissues for SSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSR1 Gene

SOURCE GeneReport for Unigene cluster for SSR1 Gene Hs.114033

genes like me logo Genes that share expressions with SSR1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSR1 Gene

Orthologs for SSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSR1 35
  • 99.77 (n)
  • 99.65 (a)
SSR1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSR1 35
  • 88.64 (n)
  • 96.7 (a)
SSR1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSR1 35
  • 93.84 (n)
  • 97.36 (a)
SSR1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssr1 35
  • 90.11 (n)
  • 95.6 (a)
Ssr1 16
Ssr1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSR1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSR1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssr1 35
  • 89.74 (n)
  • 95.97 (a)
chicken
(Gallus gallus)
Aves SSR1 35
  • 82.78 (n)
  • 91.21 (a)
SSR1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSR1 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64448 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr1 35
  • 75.65 (n)
  • 83.39 (a)
Str.2403 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11586 35
zebrafish
(Danio rerio)
Actinopterygii ssr1 35
  • 70.38 (n)
  • 79.93 (a)
ssr1 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001721 35
  • 55.25 (n)
  • 53.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0320 35
  • 53.94 (n)
  • 48.64 (a)
l(1)G0320 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea trap-1 35
  • 49.38 (n)
  • 40.28 (a)
trap-1 36
  • 37 (a)
OneToOne
Y71F9AM.6 37
  • 37 (a)
Species with no ortholog for SSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR1 Gene

ENSEMBL:
Gene Tree for SSR1 (if available)
TreeFam:
Gene Tree for SSR1 (if available)

Paralogs for SSR1 Gene

Pseudogenes.org Pseudogenes for SSR1 Gene

genes like me logo Genes that share paralogs with SSR1: view

No data available for Paralogs for SSR1 Gene

Variants for SSR1 Gene

Sequence variations from dbSNP and Humsavar for SSR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2959 -- 7,281,223(+) AGCAG(C/G)AGGTT utr-variant-3-prime, nc-transcript-variant
rs8955 -- 7,288,064(-) GGCAG(C/T)TGCAA utr-variant-3-prime, nc-transcript-variant
rs10004 - 7,310,026(-) AGGCT(C/T)GTTAG missense, reference, nc-transcript-variant
rs11071 -- 7,288,311(-) TTAAT(G/T)GGGCT utr-variant-3-prime, nc-transcript-variant
rs11719 -- 7,288,380(-) TATCA(A/G)ATTAC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SSR1 Gene

Variant ID Type Subtype PubMed ID
nsv883431 CNV Gain 21882294
nsv462623 CNV Gain 19166990
nsv470797 CNV Gain 18288195

Relevant External Links for SSR1 Gene

HapMap Linkage Disequilibrium report
SSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR1 Gene

Disorders for SSR1 Gene

Relevant External Links for SSR1

Human Genome Epidemiology (HuGE) Navigator
SSR1
genes like me logo Genes that share disorders with SSR1: view

No data available for UniProtKB/Swiss-Prot for SSR1 Gene

Publications for SSR1 Gene

  1. Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation. (PMID: 10437777) Hirama T. … Koeffler H.P. (FEBS Lett. 1999) 3 4 23
  2. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. (PMID: 1557127) Wei M.L. … Cresswell P. (Nature 1992) 3 4
  3. The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges. (PMID: 8050590) Hartmann E. … Prehn S. (FEBS Lett. 1994) 3 4
  4. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for SSR1 Gene

Sources for SSR1 Gene

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