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Aliases for SSR1 Gene

Aliases for SSR1 Gene

  • Signal Sequence Receptor, Alpha 2 3
  • Signal Sequence Receptor Subunit Alpha 3 4
  • TRAP-Alpha 3 4
  • SSR-Alpha 3 4
  • TRAPA 3 4
  • Translocon-Associated Protein Alpha Subunit 3
  • Translocon-Associated Protein Alpha 2
  • SSR Alpha Subunit 3
  • TRAP Alpha 3

External Ids for SSR1 Gene

Previous GeneCards Identifiers for SSR1 Gene

  • GC06M007272
  • GC06M007232
  • GC06M007157

Summaries for SSR1 Gene

Entrez Gene Summary for SSR1 Gene

  • The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for SSR1 Gene

SSR1 (Signal Sequence Receptor, Alpha) is a Protein Coding gene. Diseases associated with SSR1 include amyotrophic lateral sclerosis 1. Among its related pathways are Transport to the Golgi and subsequent modification and Unfolded Protein Response (UPR).

UniProtKB/Swiss-Prot for SSR1 Gene

  • TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins

Gene Wiki entry for SSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSR1 Gene

Genomics for SSR1 Gene

Regulatory Elements for SSR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSR1 Gene

Chromosome:
6
Start:
7,268,306 bp from pter
End:
7,347,446 bp from pter
Size:
79,141 bases
Orientation:
Minus strand

Genomic View for SSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSR1 Gene

Proteins for SSR1 Gene

  • Protein details for SSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43307-SSRA_HUMAN
    Recommended name:
    Translocon-associated protein subunit alpha
    Protein Accession:
    P43307
    Secondary Accessions:
    • A8K685
    • Q53GX2
    • Q53H19
    • Q5TAM3
    • Q6IB43
    • Q8NBH9
    • Q96IA2
    • Q9TNQ8
    • Q9UN49

    Protein attributes for SSR1 Gene

    Size:
    286 amino acids
    Molecular mass:
    32235 Da
    Quaternary structure:
    • Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.
    Miscellaneous:
    • Seems to bind calcium
    SequenceCaution:
    • Sequence=CAI16444.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSR1 Gene

Proteomics data for SSR1 Gene at MOPED

Post-translational modifications for SSR1 Gene

  • Ubiquitination at Lys 102
  • Glycosylation at Asn 136 and Asn 191
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SSR1 Gene

Domains & Families for SSR1 Gene

Gene Families for SSR1 Gene

Protein Domains for SSR1 Gene

Suggested Antigen Peptide Sequences for SSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P43307

UniProtKB/Swiss-Prot:

SSRA_HUMAN :
  • Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged
  • Belongs to the TRAP-alpha family.
Domain:
  • Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged
Family:
  • Belongs to the TRAP-alpha family.
genes like me logo Genes that share domains with SSR1: view

Function for SSR1 Gene

Molecular function for SSR1 Gene

UniProtKB/Swiss-Prot Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins

Gene Ontology (GO) - Molecular Function for SSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17380188
genes like me logo Genes that share ontologies with SSR1: view
genes like me logo Genes that share phenotypes with SSR1: view

Animal Model Products

miRNA for SSR1 Gene

miRTarBase miRNAs that target SSR1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SSR1 Gene

Localization for SSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSR1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSR1 Gene COMPARTMENTS Subcellular localization image for SSR1 gene
Compartment Confidence
endoplasmic reticulum 5

Gene Ontology (GO) - Cellular Components for SSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSR1: view

Pathways & Interactions for SSR1 Gene

genes like me logo Genes that share pathways with SSR1: view

Gene Ontology (GO) - Biological Process for SSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS --
GO:0006613 cotranslational protein targeting to membrane TAS 8050590
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0008284 positive regulation of cell proliferation TAS 10437777
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with SSR1: view

No data available for SIGNOR curated interactions for SSR1 Gene

Drugs & Compounds for SSR1 Gene

(1) Drugs for SSR1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with SSR1: view

Transcripts for SSR1 Gene

Unigene Clusters for SSR1 Gene

Signal sequence receptor, alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSR1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: -
SP7:

Relevant External Links for SSR1 Gene

GeneLoc Exon Structure for
SSR1
ECgene alternative splicing isoforms for
SSR1

Expression for SSR1 Gene

mRNA expression in normal human tissues for SSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSR1 Gene

This gene is overexpressed in Nasal epithelium (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSR1 Gene



SOURCE GeneReport for Unigene cluster for SSR1 Gene Hs.114033

genes like me logo Genes that share expression patterns with SSR1: view

Protein tissue co-expression partners for SSR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSR1 Gene

Orthologs for SSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSR1 35
  • 88.64 (n)
  • 96.7 (a)
SSR1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSR1 35
  • 93.84 (n)
  • 97.36 (a)
SSR1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssr1 35
  • 90.11 (n)
  • 95.6 (a)
Ssr1 16
Ssr1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSR1 35
  • 99.77 (n)
  • 99.65 (a)
SSR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssr1 35
  • 89.74 (n)
  • 95.97 (a)
oppossum
(Monodelphis domestica)
Mammalia SSR1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSR1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSR1 35
  • 82.78 (n)
  • 91.21 (a)
SSR1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSR1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssr1 35
  • 75.65 (n)
  • 83.39 (a)
Str.2403 35
African clawed frog
(Xenopus laevis)
Amphibia MGC64448 35
zebrafish
(Danio rerio)
Actinopterygii ssr1 35
  • 70.38 (n)
  • 79.93 (a)
ssr1 36
  • 75 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11586 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001721 35
  • 55.25 (n)
  • 53.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0320 35
  • 53.94 (n)
  • 48.64 (a)
l(1)G0320 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71F9AM.6 37
  • 37 (a)
trap-1 35
  • 49.38 (n)
  • 40.28 (a)
trap-1 36
  • 37 (a)
OneToOne
Species with no ortholog for SSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSR1 Gene

ENSEMBL:
Gene Tree for SSR1 (if available)
TreeFam:
Gene Tree for SSR1 (if available)

Paralogs for SSR1 Gene

Pseudogenes.org Pseudogenes for SSR1 Gene

genes like me logo Genes that share paralogs with SSR1: view

No data available for Paralogs for SSR1 Gene

Variants for SSR1 Gene

Sequence variations from dbSNP and Humsavar for SSR1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10080449 -- 7,314,999(+) AAGGC(A/C/T)GTGAG upstream-variant-2KB
rs10080445 -- 7,314,846(+) GGTTC(A/G)TGGTC upstream-variant-2KB
rs9505137 -- 7,306,654(+) gctca(C/T)gcctg intron-variant
rs9505131 -- 7,303,502(+) CTCAT(C/T)GTTTT intron-variant
rs9505130 -- 7,303,165(+) aaaaa(A/G)actca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSR1 Gene

Variant ID Type Subtype PubMed ID
nsv883431 CNV Gain 21882294
nsv462623 CNV Gain 19166990
nsv470797 CNV Gain 18288195

Variation tolerance for SSR1 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSR1 Gene

HapMap Linkage Disequilibrium report
SSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSR1 Gene

Disorders for SSR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association
Search SSR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSR1

Human Genome Epidemiology (HuGE) Navigator
SSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSR1
genes like me logo Genes that share disorders with SSR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSR1 Gene

Publications for SSR1 Gene

  1. Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation. (PMID: 10437777) Hirama T. … Koeffler H.P. (FEBS Lett. 1999) 23 67
  2. SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. (PMID: 1918067) Wada I. … Bergeron J.J. (J. Biol. Chem. 1991) 23 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for SSR1 Gene

Sources for SSR1 Gene

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