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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SSR1 Gene

protein-coding GIFtS: 61
GCID: GC06M007232

signal sequence receptor, alpha

Explore 1 disease affiliated with
SSR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Signal Sequence Receptor, Alpha¹ ²		SSR Alpha Subunit²
TRAPA¹ ² ³		Translocon-Associated Protein Alpha Subunit²
Signal Sequence Receptor Subunit Alpha² ³		Translocon-Associated Protein Subunit Alpha²
SSR-Alpha¹		TRAP Alpha²
TRAP-Alpha¹

External Ids:	HGNC: 11323¹	Entrez Gene: 6745²	Ensembl: ENSG00000124783⁷	OMIM: 600868⁵	UniProtKB: P43307³

Export aliases for SSR1 gene to outside databases

Previous GC identifers: GC06M007272 GC06M007157

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSR1:

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with

protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this

gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative

polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly

non-canonical. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SSRA_HUMAN, P43307

Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate

the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after

completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of

translocated proteins

Gene Wiki entry for SSR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SSR1 gene promoter:
MyoD LCR-F1 Meis-1b POU2F1 POU2F1a POU2F1b POU2F1c Meis-1a Meis-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSR1 promoter sequence

Search SABiosciences Chromatin IP Primers for SSR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3 Ensembl cytogenetic band: 6p24.3 HGNC cytogenetic band: 6p24.3

SSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSR1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M007232: view genomic region (about GC identifiers)

Start:	7,268,539 bp from pter	End:	7,347,679 bp from pter
Size:	79,141 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SSRA_HUMAN, P43307 (See protein sequence)

Recommended Name: Translocon-associated protein subunit alpha precursor

Size: 286 amino acids; 32235 Da

Subunit: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin

(CALX), the interaction is required for efficient folding of glycosylated proteins

Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein

Miscellaneous: Seems to bind calcium

Sequence caution: Sequence=CAI16444.1; Type=Erroneous gene model prediction;

Secondary accessions: A8K685 Q53GX2 Q53H19 Q5TAM3 Q6IB43 Q8NBH9 Q96IA2 Q9TNQ8 Q9UN49

Alternative splicing: 2 isoforms: P43307-1 P43307-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSR1: NX_P43307

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P43307

SSR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003135.2

ENSEMBL proteins:

ENSP00000418617 ENSP00000244763 ENSP00000380647 ENSP00000420730 ENSP00000417911

ENSP00000419953 ENSP00000417290 ENSP00000443020

Reactome Protein details: P43307
Human Recombinant Protein Products:

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	OriGene Purified Protein: SSR1 OriGene Protein Over-expression Lysate: SSR1 OriGene Custom Protein Services for SSR1
	GenScript Custom Purified and Recombinant Proteins Services for SSR1
	Novus Biologicals SSR1 Proteins Novus Biologicals SSR1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

SSR1 for ontologies About GeneDecksing

SSR1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	ThermoFisher Antibodies for SSR1

Assay Products for SSR1:

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	GenScript Custom Assay Services for SSR1
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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SSR1 for domains About GeneDecksing

1 InterPro domain/family:

IPR005595 TRAP_alpha

Graphical View of Domain Structure for InterPro Entry P43307

ProtoNet protein and cluster: P43307

1 Blocks protein family: IPB005595 Translocon-associated protein (TRAP)

UniProtKB/Swiss-Prot: SSRA_HUMAN, P43307

Domain: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic

C-terminus positively charged

Similarity: Belongs to the TRAP-alpha family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SSRA_HUMAN, P43307

Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate

the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after

completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of

translocated proteins

miRNA Products:		miRTarBase miRNAs that target SSR1: hsa-let-7b (MIRT005046)

		OriGene 3'-UTR Clone: SSR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSR1
		8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate SSR1 (see all 96):
		hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-578 hsa-miR-371-5p hsa-miR-1244 hsa-miR-629* hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: SSR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSR1 (see all 7) OriGene shRNA RFP: SSR1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSR1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SSR1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSR1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSR1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SSR1 (NM_003144)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SSR1
		Search LifeMap BioReagents cell lines for SSR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR1

1 GenomeRNAi human phenotype for SSR1:

Metaphase cells

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ssr1):

cardiovascular system

growth/size

homeostasis/metabolism

mortality/aging

SSR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of Chaperone Genes by XBP1(S)

	Activation of Chaperone Genes by XBP1(S)	1.00			Unfolded Protein Response	0.71
	Activation of Chaperones by IRE1alpha	0.94

Synthesis of PB1-F2

SRP-dependent cotranslational protein targeting to membrane

0.77

Translation

0.57

Expression of SSR1 (Trap alpha)

Expression of SSR1 (Trap alpha)

1.00

Protein processing in endoplasmic reticulum

Protein processing in endoplasmic reticulum

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for SSR1 (see all 8)

	Activation of Chaperone Genes by XBP1(S)
	Translation
	SRP-dependent cotranslational protein targeting to membrane
	Metabolism of proteins
	Activation of Chaperones by IRE1alpha

1 Kegg Pathway (Kegg details for SSR1):

Protein processing in endoplasmic reticulum

SSR1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SSR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/150 Interacting proteins for SSR1 (P43307^{2, 3} ENSP00000244763⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 150)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SERPINA1	P01009²^,³, ENSP00000348068⁴	MINT-4546668 MINT-4545288 MINT-4546686 MINT-4546656 I2D: score=1 STRING: ENSP00000348068
HSPA13	P48723²^,³, ENSP00000285667⁴	MINT-8258544 I2D: score=2 STRING: ENSP00000285667
PTN	P21246²^,³	MINT-63759 I2D: score=5
UTP14A	Q9BVJ6²^,³	MINT-63761 I2D: score=5
EEF1A1	P68104²^,³	MINT-6488488 I2D: score=4

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006412	translation	TAS	--
GO:0006613	cotranslational protein targeting to membrane	TAS	8050590
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	--
GO:0006987	activation of signaling protein activity involved in unfolded protein response	TAS	--
GO:0008284	positive regulation of cell proliferation	TAS	10437777

SSR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SSR1

1 HMDB Compound for SSR1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about SSR1 / SSRA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SSR1 gene:

NM_003144.3

Unigene Cluster for SSR1:

Signal sequence receptor, alpha

Hs.114033 [show with all ESTs]

Unigene Representative Sequence: NM_003144

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000474597 ENST00000475213 ENST00000244763(uc003mxf.4) ENST00000397511

ENST00000489567 ENST00000479365 ENST00000479485 ENST00000462112 ENST00000488834

ENST00000483409 ENST00000534851

miRNA Products:		OriGene 3'-UTR Clone: SSR1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSR1
		8/96 QIAGEN miScript miRNA Assays for microRNAs that regulate SSR1 (see all 96):
		hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-578 hsa-miR-371-5p hsa-miR-1244 hsa-miR-629* hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: SSR1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSR1 (see all 7) OriGene shRNA RFP: SSR1 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSR1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSR1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSR1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SSR1 (NM_003144)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSR1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SSR1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSR1

Additional cDNA sequence:

AF156965.1 AJ420492.1 AK024294.1 AK025753.1 AK026687.1 AK075562.1 AK222762.1 AK222809.1

AK291550.1 AK312653.1 BC007710.2 BT007387.1 CR456961.1 CR936719.1 Z12830.1

24/41 DOTS entries (see all 41):

DT.100877901 DT.95305566 DT.100877902 DT.92468884 DT.70101611 DT.92062932 DT.100877900 DT.100877909

DT.121402123 DT.121402463 DT.75170436 DT.86836287 DT.87017166 DT.121402434 DT.121402192 DT.100748210

DT.92468887 DT.100743154 DT.121402494 DT.100877904 DT.100877906 DT.121402453 DT.70100972 DT.92468912

24/659 AceView cDNA sequences (see all 659):

AA313551 AW189004 BE842592 BU686113 AA642356 BE871270 CR591675 BI768574

CA424805 BM703022 AL599831 AA360563 W47424 AA927866 BU683342 AK024294

BF002233 T95108 AL708632 AA450360 CN482431 BX106909 BQ014297 BX281541

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SSR1 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6	^	7a	·	7b	^	8a	·	8b
SP1:																											-								-
SP2:															-		-		-								-								-
SP3:																											-				-
SP4:															-												-
SP5:																			-		-						-

ECgene alternative splicing isoforms for SSR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SSR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGTAAAAA

About this image

SSR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

7 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Tracheal Cartilage

Chondrocytes

Lung

Bone

Autopod Long Bone

Bone

Endochondral Facial Bones

Bone

Bone

Bone

Limb

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SSR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSR1

SOURCE GeneReport for Unigene cluster: Hs.114033

SABiosciences Custom PCR Arrays for SSR1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSR1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SSR1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SSR1 gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ssr1^{1 , 5}	signal sequence receptor, alpha^{1, 5}	89.86(n)¹ 95.45(a)¹		13 (17.86 cM)⁵ 107513¹ NM_025965.3¹ NP_080241.3¹ 37971401⁵
chicken (Gallus gallus)	Aves	SSR1¹	signal sequence receptor, alpha	82.05(n) 90.56(a)		420871 NM_001006375.1 NP_001006375.1
lizard (Anolis carolinensis)	Reptilia	SSR1⁶	--	86(a)	1 ↔ 1	GL343311.1(463547-479791)
African clawed frog (Xenopus laevis)	Amphibia	MGC64448²	hypothetical protein MGC64448	78.59(n)		BC056853.1
zebrafish (Danio rerio)	Actinopterygii	ssr1²	signal sequence receptor, alpha	74.69(n)		373100 BC056339.1
fruit fly (Drosophila melanogaster)	Insecta	l(1)G0320¹	lethal (1) G0320	51.94(n) 44.57(a)		326234 NM_132339.2 NP_572567.1
worm (Caenorhabditis elegans)	Secernentea	Y71F9AM.6³ trap-1¹	Protein TRAP-1¹	37(a)³ 50(n)¹ 40.18(a)¹		I(2928398-2929352)³ 171865¹ NM_058675.3¹ NP_491076.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G21160¹	translocon-associated protein subunit alpha	43.69(n) 32.77(a)		816651 NM_127686.3 NP_565498.1
rice (Oryza sativa)	Liliopsida	Os06g0715500¹	hypothetical protein	44.14(n) 27.48(a)		4342072 NM_001065120.1 NP_001058585.1

ENSEMBL Gene Tree for SSR1 (if available)
TreeFam Gene Tree for SSR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SSR1 gene

SSR1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for SSR1
PGOHUM00000248634 PGOHUM00000243417

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11962185^1,2	C,F,H,	--	7280812(+)	`CCTGCG/ATGAGG`	1	--	ds500¹		4		WA NA	242
rs184944774^1,2		--	7280890(+)	`AATCTG/TAAATC`	1	--	ds500¹		0	--	--	--	--
rs147012524^1,2		--	7280983(+)	`GCAGTC/GGCGTG`	1	--	ds500¹		0	--	--	--	--
rs147628654^1,2		--	7280984(+)	`CAGTGA/GCGTGA`	1	--	ds500¹		0	--	--	--	--
rs7751484^1,2	C,F,A,H,	--	7281048(+)	`GCCTCC/ATGAGT`	1	--	ds500¹		2		NA	4
rs150130940^1,2		--	7281114(+)	`GAGACA/GAGGTT`	1	--	ds500¹		0	--	--	--	--
rs189059159^1,2		--	7281172(+)	`TCCACC/TTCAGC`	1	--	ds500¹		0	--	--	--	--
rs138579194^1,2		--	7281218(+)	`GTGCCC/TGGCCA`	1	--	ds500¹		0	--	--	--	--
rs7755963^1,2	C,A,H,	--	7281272(+)	`GATTTT/CTTTTC`	1	--	ds500¹		4		NS EA	396
rs192717575^1,2		--	7281306(+)	`GGATTC/TCTCGT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SSR1 (7268539 - 7347679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SSR1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SSR1 for disorders           About GeneDecksing

OMIM gene information: 600868    OMIM disorders: --

1 disease for SSR1:    About MalaCards

double outlet right ventricle

Human Genome Epidemiology (HuGE) Navigator: SSR1 (1 document)

Export disorders for SSR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SSR1 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with SSR1)

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Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation. (PubMed id 10437777)^{1, 2, 9} Hirama T.... Koeffler H.P. (1999)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{1, 2} Zhang H.... Aebersold R. (2003)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges. (PubMed id 8050590)^{1, 2} Hartmann E. and Prehn S. (1994)
HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. (PubMed id 1557127)^{1, 2} Wei M.L. and Cresswell P. (1992)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6745	HGNC: 11323	AceView: SSR1	Ensembl:ENSG00000124783	euGenes: HUgn6745
ECgene: SSR1	Kegg: 6745	H-InvDB: SSR1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SSR1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SSR1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SSR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SSR1 gene:
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GeneCards and IP:
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signal sequence receptor, alpha

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signal sequence receptor, alpha

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