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SSR1 Gene

protein-coding   GIFtS: 63
GCID: GC06M007232

Signal Sequence Receptor, Alpha

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Sequence Receptor, Alpha1 2     Translocon-Associated Protein Alpha1
Signal Sequence Receptor Subunit Alpha2 3     SSR Alpha Subunit2
SSR-alpha2 3     Translocon-Associated Protein Alpha Subunit2
TRAP-alpha2 3     Translocon-Associated Protein Subunit Alpha2
TRAPA2 3     TRAP Alpha2

External Ids:    HGNC: 113231   Entrez Gene: 67452   Ensembl: ENSG000001247837   OMIM: 6008685   UniProtKB: P433073   

Export aliases for SSR1 gene to outside databases

Previous GC identifers: GC06M007272 GC06M007157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSR1 Gene:
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with
protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by
this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative
polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly
non-canonical. (provided by RefSeq, Jul 2008)

GeneCards Summary for SSR1 Gene:
SSR1 (signal sequence receptor, alpha) is a protein-coding gene.

UniProtKB/Swiss-Prot: SSRA_HUMAN, P43307
Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus
after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding
of translocated proteins

Gene Wiki entry for SSR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSR1 gene promoter:
         MyoD   LCR-F1   Meis-1b   POU2F1   POU2F1a   POU2F1b   POU2F1c   Meis-1a   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSR1 promoter sequence
   Search Chromatin IP Primers for SSR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p24.3

SSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSR1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M007232:  view genomic region     (about GC identifiers)

Start:
7,268,539 bp from pter      End:
7,347,679 bp from pter
Size:
79,141 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SSRA_HUMAN, P43307 (See protein sequence)
Recommended Name: Translocon-associated protein subunit alpha precursor  
Size: 286 amino acids; 32235 Da
Subunit: Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin
(CALX), the interaction is required for efficient folding of glycosylated proteins
Miscellaneous: Seems to bind calcium
Sequence caution: Sequence=CAI16444.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K685 Q53GX2 Q53H19 Q5TAM3 Q6IB43 Q8NBH9 Q96IA2 Q9TNQ8 Q9UN49
Alternative splicing: 2 isoforms:  P43307-1   P43307-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSR1: NX_P43307

Explore proteomics data for SSR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys102
  • Glycosylation2 at Asn136, Asn191
  • Modification sites at PhosphoSitePlus

  • See SSR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003135.2  
    ENSEMBL proteins: 
     ENSP00000418617   ENSP00000244763   ENSP00000380647   ENSP00000420730   ENSP00000417911  
     ENSP00000419953   ENSP00000417290   ENSP00000443020  
    Reactome Protein details: P43307

    SSR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for SSR1
    OriGene Protein Over-expression Lysate for SSR1
    OriGene MassSpec for SSR1
    OriGene Custom Protein Services for SSR1
    GenScript Custom Purified and Recombinant Proteins Services for SSR1
    Novus Biologicals SSR1 Proteins
    Novus Biologicals SSR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SSR1 

     
    antibodies-online proteins for SSR1 (9 products) 

     
    antibodies-online peptides for SSR1

    SSR1 Antibody Products:

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    Abcam antibodies for SSR1 (Q6IB43, P43307)
    Browse Antibodies at Cloud-Clone Corp.
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    antibodies-online antibodies for SSR1 (28 products) 

    SSR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SSR1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SSR1 
    antibodies-online kits for SSR1 (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005595 TRAP_alpha

    Graphical View of Domain Structure for InterPro Entry P43307

    ProtoNet protein and cluster: P43307

    1 Blocks protein domain: IPB005595 Translocon-associated protein (TRAP)

    UniProtKB/Swiss-Prot: SSRA_HUMAN, P43307
    Domain: Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the
    cytoplasmic C-terminus positively charged
    Similarity: Belongs to the TRAP-alpha family


    Find genes that share domains with SSR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSRA_HUMAN, P43307
    Function: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby
    regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus
    after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding
    of translocated proteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17380188
         
    Find genes that share ontologies with SSR1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SSR1:
     Metaphase cells 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ssr1):
     cardiovascular system  growth/size/body  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with SSR1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SSR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SSR1:
    hsa-mir-1 (MIRT024095), hsa-mir-218-5p (MIRT046983), hsa-let-7b-5p (MIRT005046)

    Block miRNA regulation of human, mouse, rat SSR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSR1 (see all 96):
    hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-578 hsa-miR-371-5p hsa-miR-1244 hsa-miR-629* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidSSR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SSR1
    Predesigned siRNA for gene silencing in human, mouse, rat SSR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SSR1

    Clone
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    OriGene clones in human, mouse for SSR1 (see all 6)
    OriGene ORF clones in mouse, rat for SSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR1 (NM_003144)
    Sino Biological Human cDNA Clone for SSR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SSR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SSR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSRA_HUMAN, P43307: Endoplasmic reticulum membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular1
    golgi apparatus1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SSR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSR1 About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Influenza Viral RNA Transcription and Replication
    SRP-dependent cotranslational protein targeting to membrane0.83
    Translation0.82
    3Gene Expression
    Gene Expression0.40
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with SSR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for SSR1
        XBP1(S) activates chaperone genes
    SRP-dependent cotranslational protein targeting to membrane


    1 Kegg Pathway  (Kegg details for SSR1):
        Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSR1
    Interactions:

        Search GeneGlobe Interaction Network for SSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSR1 (P433071, 2, 3 ENSP000002447634) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERPINA1P010091, 2, 3, ENSP000003480684EBI-714168,EBI-986224 MINT-4546668 MINT-4545288 MINT-4546686 MINT-4546656 I2D: score=1 STRING: ENSP00000348068
    HSPA13P487232, 3, ENSP000002856674MINT-8258544 I2D: score=2 STRING: ENSP00000285667
    EDEM1Q926112, 3, ENSP000002564974MINT-4546760 I2D: score=1 STRING: ENSP00000256497
    SSR4P515712, 3, ENSP000003173314MINT-4546703 I2D: score=1 STRING: ENSP00000317331
    PTNP212462, 3MINT-63759 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS--
    GO:0006613cotranslational protein targeting to membrane TAS8050590
    GO:0006614SRP-dependent cotranslational protein targeting to membrane TAS--
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0008284positive regulation of cell proliferation TAS10437777

    Find genes that share ontologies with SSR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSR1 (SSRA)

    1 HMDB Compound for SSR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSR1 gene: 
    NM_003144.3  

    Unigene Cluster for SSR1:

    Signal sequence receptor, alpha
    Hs.114033  [show with all ESTs]
    Unigene Representative Sequence: NM_003144
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474597 ENST00000475213 ENST00000244763(uc003mxf.4) ENST00000397511
    ENST00000489567 ENST00000479365 ENST00000479485 ENST00000462112 ENST00000488834
    ENST00000483409 ENST00000534851
    miRNA
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    Block miRNA regulation of human, mouse, rat SSR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSR1 (see all 96):
    hsa-miR-323-3p hsa-miR-3194-5p hsa-miR-15a hsa-miR-578 hsa-miR-371-5p hsa-miR-1244 hsa-miR-629* hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidSSR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSR1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSR1 (NM_003144)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for SSR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSR1
      QuantiTect SYBR Green Assays in human, mouse, rat SSR1
      QuantiFast Probe-based Assays in human, mouse, rat SSR1

    Additional mRNA sequence: 

    AF156965.1 AJ420492.1 AK024294.1 AK025753.1 AK026687.1 AK075562.1 AK222762.1 AK222809.1 
    AK291550.1 AK312653.1 BC007710.2 BT007387.1 CR456961.1 CR936719.1 Z12830.1 

    Selected DOTS entries (see all 39):

    DT.100877901  DT.95305566  DT.100877902  DT.70101611  DT.92468884  DT.121402463  DT.92062932  DT.100877900 
    DT.100877909  DT.75170436  DT.86836287  DT.121402123  DT.87017166  DT.121402434  DT.100748210  DT.92468887 
    DT.100743154  DT.121402494  DT.100877904  DT.121402453  DT.70100972  DT.95095864  DT.100877906  DT.121402467 

    Selected AceView cDNA sequences (see all 659):

    AA393393 CA848139 CA771060 BM839535 T32708 BE842592 BU159188 BM685131 
    CR591675 CA311548 AI589014 W47424 BU156413 CR599599 BM984958 AL708632 
    AI755274 BQ014005 AA927866 AA504181 BU683354 BQ431898 BQ014297 AA297530 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSR1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                                                                -                       -               
    SP2:                                            -     -     -                       -                       -               
    SP3:                                                                                -           -                           
    SP4:                                            -                                   -                                       
    SP5:                                                        -     -                 -                                       


    ECgene alternative splicing isoforms for SSR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTAAAAA
    SSR1 Expression
    About this image


    SSR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Long Bone
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Chondrocytes Tracheal Cartilage
             Tracheal Cartilage
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Laryngeal Cartilage
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Pelvic Girdle
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SSR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.114033
        Custom PCR Arrays for SSR1
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat SSR1
    QuantiFast Probe-based Assays in human, mouse, rat SSR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SSR1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssr11 , 5 signal sequence receptor, alpha1, 5 90.11(n)1
    95.6(a)1
      13 (17.86 cM)5
    1075131  NM_025965.31  NP_080241.31 
     379714015 
    chicken
    (Gallus gallus)
    Aves SSR11 signal sequence receptor, alpha 82.78(n)
    91.21(a)
      420871  NM_001006375.1  NP_001006375.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSR16
    signal sequence receptor, alpha
    84(a)
    1 ↔ 1
    GL343311.1(458981-480065)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644482 hypothetical protein MGC64448 78.59(n)    BC056853.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ssr12 signal sequence receptor, alpha 74.69(n)   373100  BC056339.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G03201 lethal (1) G0320 53.94(n)
    48.64(a)
      326234  NM_132339.2  NP_572567.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71F9AM.63
    trap-11
    trap-11 37(a)3
    49.38(n)1
    40.28(a)1
      I(2928398-2929352)3
    1718651  NM_058675.41  NP_491076.11 


    ENSEMBL Gene Tree for SSR1 (if available)
    TreeFam Gene Tree for SSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSR1 gene

    Find genes that share paralogs with SSR1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SSR1
    PGOHUM00000248634 PGOHUM00000243417


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSR1 (see all 821)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119621851,2
    C,F,H--7280812(+) CCTGCG/ATGAGG 1 -- ds50014Minor allele frequency- A:0.06WA NA 242
    rs1849447741,2
    --7280890(+) AATCTG/TAAATC 1 -- ds50010--------
    rs2020769991,2
    C--7280941(+) TGAAC-/TTTTTT 1 -- ds50010--------
    rs1470125241,2
    --7280983(+) GCAGTC/GGCGTG 1 -- ds50010--------
    rs1476286541,2
    --7280984(+) CAGTGA/GCGTGA 1 -- ds50010--------
    rs77514841,2
    C,F,A,H--7281048(+) GCCTCC/ATGAGT 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1501309401,2
    --7281114(+) GAGACA/GAGGTT 1 -- ds50010--------
    rs1890591591,2
    --7281172(+) TCCACC/TTCAGC 1 -- ds50010--------
    rs1385791941,2
    --7281218(+) GTGCCC/TGGCCA 1 -- ds50010--------
    rs77559631,2
    C,A,H--7281272(+) GATTTT/CTTTTC 1 -- ds50014Minor allele frequency- C:0.00NS EA 396

    HapMap Linkage Disequilibrium report for SSR1 (7268539 - 7347679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SSR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv462623CNV Gain19166990
    nsv883431CNV Gain21882294
    nsv470797CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSR1
    DNA2.0 Custom Variant and Variant Library Synthesis for SSR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600868    OMIM disorders: --


    Find genes that share disorders with SSR1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SSR1 (1 document)

    Export disorders for SSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSR1 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with SSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation. (PubMed id 10437777)1, 2, 9 Hirama T.... Koeffler H.P. (FEBS Lett. 1999)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges. (PubMed id 8050590)1, 2 Hartmann E. and Prehn S. (FEBS Lett. 1994)
    9. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides. (PubMed id 1557127)1, 2 Wei M.L. and Cresswell P. (Nature 1992)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6745 HGNC: 11323 AceView: SSR1 Ensembl:ENSG00000124783 euGenes: HUgn6745
    ECgene: SSR1 Kegg: 6745 H-InvDB: SSR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSR1 gene:
    Search GeneIP for patents involving SSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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