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SSPO Gene

protein-coding   GIFtS: 48
GCID: GC07P149473          (predicted)

SCO-Spondin

(Previous name: SCO-spondin homolog (Bos taurus))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SCO-spondin1 2     SCO Protein, Thrombospondin Domain Containing2
SCO-Spondin Homolog (Bos Taurus)1 2     KIAA20363
Subcommissural Organ Spondin1 2     EC 3.4.21.98
SCO Protein1     EC 3.4.24.828
Thrombospondin Domain Containing1     

External Ids:    HGNC: 219981   Entrez Gene: 231452   Ensembl: ENSG000001975587   UniProtKB: A2VEC93   

Export aliases for SSPO gene to outside databases

Previous GC identifers: GC07P148912 GC07P149143 GC07P149108 GC07P143550


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SSPO Gene:
SSPO (SCO-spondin) is a protein-coding gene. Diseases associated with SSPO include neuroblastoma, and ataxia. GO annotations related to this gene include peptidase inhibitor activity.

UniProtKB/Swiss-Prot: SSPO_HUMAN, A2VEC9
Function: Involved in the modulation of neuronal aggregation. May be involved in developmental events during the
formation of the central nervous system (By similarity)

Gene Wiki entry for SSPO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSPO gene promoter:
         HNF-4alpha2   HNF-4alpha1   c-Ets-1   HEN1   Max   FAC1   STAT3   Zic3   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SSPO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

SSPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSPO gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P149473:  view genomic region     (about GC identifiers)

Start:
149,473,131 bp from pter      End:
149,531,068 bp from pter
Size:
57,938 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 148,811,145-148,869,073     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SSPO_HUMAN, A2VEC9 (See protein sequence)
Recommended Name: SCO-spondin precursor  
Size: 5147 amino acids; 547504 Da
Sequence caution: Sequence=BAC98376.1; Type=Erroneous initiation;
Secondary accessions: Q76B61
Alternative splicing: 2 isoforms:  A2VEC9-1   A2VEC9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSPO: NX_A2VEC9

Explore proteomics data for SSPO at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn88, Asn130, Asn261, Asn514, Asn819, Asn911, Asn944, Asn986, Asn1352, Asn1650,
                                 Asn1663, Asn1809, Asn1993, Asn2030, Asn2133, Asn2645, Asn2694, Asn2936, Asn2967, Asn3062 (see all 43)
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for SSPO (A2VEC9)
     CPDGSDE  CSRSCGGG 


    See SSPO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_940857.2  Reactome Protein details: A2VEC9

    SSPO Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SSPO

    SSPO Antibody Products:

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    Cloud-Clone Corp. Antibodies for SSPO
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    SSPO Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SSPO
    Cloud-Clone Corp. CLIAs for SSPO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 13):
     IPR002172 LDrepeatLR_classA_rpt
     IPR000884 Thrombospondin_1_rpt
     IPR014853 Unchr_dom_Cys-rich
     IPR006552 VWC_out
     IPR002919 TIL_dom

    Graphical View of Domain Structure for InterPro Entry A2VEC9

    ProtoNet protein and cluster: A2VEC9

    UniProtKB/Swiss-Prot: SSPO_HUMAN, A2VEC9
    Similarity: Belongs to the thrombospondin family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 EMI domain
    Similarity: Contains 1 F5/8 type C domain
    Similarity: Contains 10 LDL-receptor class A domains
    Similarity: Contains 6 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 24 TSP type-1 domains
    Similarity: Contains 3 VWFC domains
    Similarity: Contains 3 VWFD domains


    SSPO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSPO_HUMAN, A2VEC9
    Function: Involved in the modulation of neuronal aggregation. May be involved in developmental events during the
    formation of the central nervous system (By similarity)

         Enzyme Numbers (IUBMB): EC 3.4.24.822 EC 3.4.21.92

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030414peptidase inhibitor activity IEA--
         
    SSPO for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SSPO:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSPO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSPO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSPO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSPO

    miRNA
    Products:
        
    miRTarBase miRNAs that target SSPO:
    hsa-mir-671-5p (MIRT039261)

    Block miRNA regulation of human, mouse, rat SSPO using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SSPO
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSPO

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SSPO (NM_198455)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSPO
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SSPO

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SSPO 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSPO_HUMAN, A2VEC9: Secreted, extracellular space (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    nucleus2
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS--

    SSPO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for SSPO
        O-glycosylation of TSR domain-containing proteins



    SSPO for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSPO
    Interactions:

        Search GeneGlobe Interaction Network for SSPO

    Selected Interacting proteins for SSPO (A2VEC93) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    SSPO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSPO



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SSPO gene: 
    NM_198455.2  

    Unigene Cluster for SSPO:

    SCO-spondin homolog (Bos taurus)
    Hs.632022  [show with all ESTs]
    Unigene Representative Sequence: NM_198455
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486824(processed_transcript) ENST00000465080(processed_transcript) ENST00000477518(processed_transcript) ENST00000493502(processed_transcript) ENST00000475488(processed_transcript)
    ENST00000472797(processed_transcript) ENST00000484709(processed_transcript) ENST00000481772(processed_transcript) ENST00000478854(processed_transcript) ENST00000464974(processed_transcript)
    ENST00000493567(processed_transcript) ENST00000492965(processed_transcript) ENST00000488835(processed_transcript) ENST00000461331(processed_transcript) ENST00000465639(processed_transcript)
    ENST00000472850(processed_transcript) ENST00000378016(processed_transcript) ENST00000262089(processed_transcript)
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate SSPO
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSPO
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSPO (NM_198455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSPO
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SSPO
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SSPO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSPO
      QuantiTect SYBR Green Assays in human, mouse, rat SSPO
      QuantiFast Probe-based Assays in human, mouse, rat SSPO

    Additional mRNA sequence: 

    AB111888.1 AK093431.1 AK123170.1 AK124542.1 AK127639.1 AY927596.1 AY927597.1 AY927598.1 

    14 DOTS entries:

    DT.40120872  DT.101978156  DT.121117204  DT.91724197  DT.101978155  DT.121117281  DT.75188456  DT.86842802 
    DT.121117166  DT.121117174  DT.121117177  DT.121117239  DT.121117258  DT.121117255 

    Selected AceView cDNA sequences (see all 125):

    BU682460 CD723657 BQ270712 AA854703 AI478769 AA426274 AI680469 AI217935 
    CR616081 BM661857 BU726965 T82326 AA936481 AI870440 AW467663 CN479285 
    AI807308 AA328896 BM843562 BQ581619 BX118218 BM689825 AI992185 AI862979 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSPO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAGACTCC
    SSPO Expression
    About this image


    SSPO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    SSPO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSPO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632022
        Custom PCR Arrays for SSPO
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SSPO gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sspo1 , 5 SCO-spondin1, 5 79.5(n)1
    76.18(a)1
      6 (23.42 cM)5
    2433691  NM_173428.31  NP_775604.31 
     484482295 
    chicken
    (Gallus gallus)
    Aves SSPO1 SCO-spondin homolog (Bos taurus) 62.54(n)
    53.89(a)
      420367  NM_001006351.2  NP_001006351.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004971291 SCO-spondin-like 57.42(n)
    51.73(a)
      100497129  XM_002942577.2  XP_002942623.2 
    zebrafish
    (Danio rerio)
    Actinopterygii scospondin1 subcommissural organ spondin 52.3(n)
    44.44(a)
      100036547  XM_001920299.4  XP_001920334.4 


    ENSEMBL Gene Tree for SSPO (if available)
    TreeFam Gene Tree for SSPO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSPO gene
    1 SIMAP similar gene for SSPO using alignment to 1 protein entry:     SSPO_HUMAN:
    MUC2

    SSPO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSPO (see all 2285)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs16594351,2
    C,F--148809299(+) GGCAGC/TCCTCA 1 -- us2k12Minor allele frequency- T:0.02MN WA 302
    rs1144471051,2
    --148809307(+) TCAGCC/GCTCAG 1 -- us2k10--------
    rs102365931,2
    C,F--148809395(+) CGCTGC/TGCCCA 1 -- us2k13Minor allele frequency- T:0.09NA WA 122
    rs1392533791,2
    --148809408(+) CCTGAA/GAGCTC 1 -- us2k10--------
    rs1827652111,2
    --148809511(+) TTTACA/GGGAAA 1 -- us2k10--------
    rs1499847181,2
    --148809557(+) TGCTGA/CCTGAT 1 -- us2k10--------
    rs770280341,2
    C--148809624(+) CCCTTG/CAGCTC 1 -- us2k12Minor allele frequency- C:0.11NA 122
    rs1452275641,2
    --148809654(+) CAAGGA/GTGAGT 1 -- us2k10--------
    rs1413076871,2
    --148809657(+) GGATGA/GGTGCC 1 -- us2k10--------
    rs102371581,2
    C,F--148809668(+) TGGAAG/AAGCGC 1 -- us2k12Minor allele frequency- A:0.16WA 120

    HapMap Linkage Disequilibrium report for SSPO (149473131 - 149531068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SSPO (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010383CNV Deletion20482838
    esv1058616CNV Deletion17803354
    esv2735334CNV Deletion23290073
    nsv521861CNV Loss19592680
    dgv844n27CNV Loss19166990
    nsv889409CNV Loss21882294
    dgv7530n71CNV Loss21882294
    dgv7529n71CNV Loss21882294
    nsv517242CNV Loss19592680
    nsv824389CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SSPO
    DNA2.0 Custom Variant and Variant Library Synthesis for SSPO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for SSPO:    
    About MalaCards
    neuroblastoma    ataxia    neuronitis


    SSPO for disorders           About GeneDecksing

    Genetic Association Database (GAD): SSPO
    Human Genome Epidemiology (HuGE) Navigator: SSPO (3 documents)

    Export disorders for SSPO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSPO gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with SSPO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. (PubMed id 11008217)1, 3, 9 Gobron S....Meiniel A. (Glia 2000)
    2. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. (PubMed id 17126404)1, 2, 9 Meiniel O. and Meiniel A. (Brain Res. Brain Res. Rev. 2007)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. (PubMed id 8743952)1, 3 Gobron S....Meiniel A. (J. Cell. Sci. 1996)
    5. Placental expression of SCO-spondin during mouse and human development. (PubMed id 15053980)1, 9 GonAsalves-Mendes N....Sapin V. (Gene Expr. Patterns 2004)
    6. The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines. (PubMed id 14692680)1, 9 Meiniel A....Dastugue B. (Int. Rev. Cytol. 2003)
    7. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    8. The lengthening of a giant protein: when, how, and why? (PubMed id 18046595)1 Meiniel O....Petit D. (J. Mol. Evol. 2008)
    9. A genome-wide association study of sporadic ALS in a homogenous Irish population. (PubMed id 18057069)4 Cronin S....Hardiman O. (Hum. Mol. Genet. 2008)
    10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23145 HGNC: 21998 AceView: KIAA0543.2 Ensembl:ENSG00000197558 euGenes: HUgn23145
    ECgene: SSPO H-InvDB: SSPO

    (According to HUGE)
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    HUGE: KIAA2036

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSPO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSPO gene:
    Search GeneIP for patents involving SSPO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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