SSPO Gene
protein-coding GIFtS : 45
GCID: GC07 P149473 (predicted)
SCO-spondin homolog (Bos taurus)
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Aliasesfor SSPO gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases SCO-Spondin Homolog (Bos Taurus) 1 2 KIAA20363 SCO-Spondin1 EC 3.4.21.98 FLJ361121 EC 3.4.24.828 KIAA05431
Export aliases for SSPO gene to outside databases Previous GC identifers: GC07P148912 GC07P149143 GC07P149108 GC07P143550
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Summariesfor SSPO gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: SSPO_HUMAN, A2VEC9 Function : Involved in the modulation of neuronal aggregation. May be involved in developmental events during theformation of the central nervous system (By similarity) Gene Wiki entry for SSPO
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Genomic Viewsfor SSPO gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SSPO gene promoter: HNF-4alpha2 HNF-4alpha1 c-Ets-1 HEN1 Max FAC1 STAT3 Zic3 c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for SSPO Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSPO
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1 SSPO Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07P149473: view genomic region
(about GC identifiers )
Start:
149,473,131 bp from pter
End:
149,531,068 bp from pter
Size:
57,938 bases
Orientation:
plus strand
1 alternative location : Chr 7+,CRA_TCAG 148,811,145-148,869,073
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Proteinsfor SSPO gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: SSPO_HUMAN, A2VEC9 (See
protein sequence )Recommended Name: SCO-spondin precursor Size : 5147 amino acids; 547504 Da
Subcellular location : Secreted, extracellular space (By similarity)
Sequence caution : Sequence=BAC98376.1; Type=Erroneous initiation;
Secondary accessions : Q76B61Alternative splicing : 2 isoforms : A2VEC9-1 A2VEC9-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SSPO: NX_A2VEC9 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A2VEC9 2 DME Specific Peptides for SSPO (A2VEC9 ) SSPO Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_940857.2 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005615 extracellular space
TAS --
SSPO for ontologies About GeneDecksing SSPO Antibody Products: Assay Products for SSPO:
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Protein
Domains / Familiesfor SSPO gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SSPO for domains About GeneDecksing 5/12 InterPro domains/families (see all 12 ):
Graphical View of Domain Structure for InterPro Entry A2VEC9 ProtoNet protein and cluster: A2VEC9
UniProtKB/Swiss-Prot: SSPO_HUMAN, A2VEC9 Similarity : Belongs to the thrombospondin familySimilarity : Contains 1 CTCK (C-terminal cystine knot-like) domainSimilarity : Contains 2 EGF-like domainsSimilarity : Contains 1 EMI domainSimilarity : Contains 1 F5/8 type C domainSimilarity : Contains 10 LDL-receptor class A domainsSimilarity : Contains 6 TIL (trypsin inhibitory-like) domainsSimilarity : Contains 24 TSP type-1 domainsSimilarity : Contains 3 VWFC domainsSimilarity : Contains 3 VWFD domains
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Functionfor SSPO gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: SSPO_HUMAN, A2VEC9 Function : Involved in the modulation of neuronal aggregation. May be involved in developmental events during theformation of the central nervous system (By similarity) Enzyme Numbers (IUBMB): EC 3.4.24.82 2 EC 3.4.21.9 2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPO
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0030414 peptidase inhibitor activity
IEA --
SSPO for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for SSPO :
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Pathways & Interactionsfor SSPO gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSPO 4 Interacting proteins for SSPO (A2VEC9 3 ) via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0007155 cell adhesion
IEA --
SSPO for ontologies About GeneDecksing
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Drugs & Compoundsfor SSPO gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SSPO Search CenterWatch for drugs/clinical trials and news about SSPO
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Transcriptsfor SSPO gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SSPO gene: NM_198455.2 Unigene Cluster for SSPO:
SCO-spondin homolog (Bos taurus) Hs.632022 [show with all ESTs ] Unigene Representative Sequence: NM_198455 18 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000486824 ENST00000465080 ENST00000477518 ENST00000493502 ENST00000475488 ENST00000472797 ENST00000484709 ENST00000481772 ENST00000478854 ENST00000464974 ENST00000493567 (uc003wgi.1 ) ENST00000492965 ENST00000488835 ENST00000461331 ENST00000465639 ENST00000472850 ENST00000378016 (uc010lpk.3 uc010lpm.1 uc003wgg.2 uc003wgh.2 )ENST00000262089 (uc010lpl.1 ) Additional cDNA sequence: AB111888.1 AK093431.1 AK123170.1 AK124542.1 AK127639.1 AY927596.1 AY927597.1 AY927598.1
14 DOTS entries : DT.40120872 DT.101978156
DT.121117204 DT.91724197 DT.101978155 DT.121117281 DT.75188456 DT.86842802 DT.121117166 DT.121117174 DT.121117177 DT.121117239 DT.121117258 DT.121117255 24/125 AceView cDNA sequences (see all 125 ):
AI478769 BQ581619 BM843562 BQ054043 AA936481 CN479285 AI807308 BU682460 AI862979 BF980931 CD513434 BX366047 BX118218 BM661857 T82326 BE646060 BM689825 CR617664 AA854703 AA328896 AI087221 AI217935 AI870440 BU164247 GeneLoc Exon Structure
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Expression for SSPO gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SSPO expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCAAGACTCC
About this image SSPO expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See SSPO Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SSPO SOURCE GeneReport for Unigene cluster: Hs.632022 SABiosciences Custom PCR Arrays for SSPO Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SSPOBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SSPO QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SSPO QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SSPO In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPO
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Orthologsfor SSPO gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for SSPO gene from 3/6 species (see all 6 ) About this table
ENSEMBL Gene Tree for SSPO (if available)TreeFam Gene Tree for SSPO (if available)
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Paralogsfor SSPO gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor SSPO gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 7 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SSPO (149473131 - 149531068 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for SSPO 6 CNVs : 52149 53471 52148 3709 52146 52147 1 Indel : 28490
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor SSPO gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SSPO for disorders About GeneDecksing 3 diseases for SSPO : About MalaCards ataxia neuroblastoma neuronitis Human Genome Epidemiology (HuGE) Navigator: SSPO (3 documents) Export disorders for SSPO gene to outside databases
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Publicationsfor SSPO gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SSPO gene, integrated from 9 sources (see all 23 ): (articles sorted by number of sources associating them with SSPO) Utopia : connect your pdf to the dynamic world of online information
Subcommissural organ/Reissner's fiber complex: charac terization of SCO-spondin, a glycoprotein with potent activity on neurite outgr owth. (PubMed id 11008217) 1 , 3, 9 Gobron S....Meiniel A. (2000) The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. (PubMed id 17126404) 1 , 2 , 9 Meiniel O. and Meiniel A. (2007) SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. (PubMed id 8743952) 1 , 3 Gobron S....Meiniel A. (1996) Placental expression of SCO-spondin during mouse and human development. (PubMed id 15053980) 1 , 9 Goncalves-Mendes N....Sapin V. (2004) The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines. (PubMed id 14692680) 1 , 9 Meiniel A....Dastugue B. (2003) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 Bailey S.D....Anand S. (2010) Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121) 1 Talmud P.J.... . (2009) The lengthening of a giant protein: when, how, and why? (PubMed id 18046595) 1 Meiniel O....Petit D. (2008) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569) 1 Lim J.... Zoghbi H.Y. (2006) Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807) 1 Cheng J....Gingeras T.R. (2005)
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External Searches for SSPO gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SSPO gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SSPO gene
(According to HUGE )
About This Section
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Specialized Databases showing SSPO gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for SSPO Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for SSPO gene: Search GeneIP for patents involving SSPO GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SSPO gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for SSPO OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SSPO OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SSPO Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for SSPO Browse OriGene untagged cDNA clones in CMV expression vector OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SSPO Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SSPO OriGene Custom Protein Services for SSPO OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSPO Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSPO QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSPO QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SSPO QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SSPO QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SSPO
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SSPO Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPO
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Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SSPO
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