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Aliases for SSPO Gene

Aliases for SSPO Gene

  • SCO-Spondin 2 3
  • Thrombospondin Domain Containing 2
  • SCO-Spondin Homolog (Bos Taurus) 2
  • Subcommissural Organ Spondin 2
  • EC 3.4.24.82 64
  • SCO Protein 2
  • EC 3.4.21.9 64
  • KIAA2036 4

External Ids for SSPO Gene

Summaries for SSPO Gene

GeneCards Summary for SSPO Gene

SSPO (SCO-Spondin) is a Protein Coding gene. GO annotations related to this gene include peptidase inhibitor activity.

UniProtKB/Swiss-Prot for SSPO Gene

  • Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Gene Wiki entry for SSPO Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSPO Gene

Genomics for SSPO Gene

Genomic Location for SSPO Gene

Start:
149,776,042 bp from pter
End:
149,833,979 bp from pter
Size:
57,938 bases
Orientation:
Plus strand

Genomic View for SSPO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSPO Gene

Regulatory Elements for SSPO Gene

Proteins for SSPO Gene

  • Protein details for SSPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VEC9-SSPO_HUMAN
    Recommended name:
    SCO-spondin
    Protein Accession:
    A2VEC9
    Secondary Accessions:
    • Q76B61

    Protein attributes for SSPO Gene

    Size:
    5147 amino acids
    Molecular mass:
    547504 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC98376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSPO Gene

Proteomics data for SSPO Gene at MOPED

Selected DME Specific Peptides for SSPO Gene

Post-translational modifications for SSPO Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn88, Asn130, Asn261, Asn514, Asn819, Asn911, Asn944, Asn986, Asn1352, Asn1650, Asn1663, Asn1809, Asn1993, Asn2030, Asn2133, Asn2645, Asn2694, Asn2936, Asn2967, Asn3062, Asn3116, Asn3163, Asn3173, Asn3310, Asn3399, Asn3512, Asn3522, Asn3599, Asn3626, Asn3792, Asn3914, Asn3946, Asn4139, Asn4346, Asn4417, Asn4731, Asn4748, Asn4753, Asn4863, Asn4903, Asn4948, Asn4955, and Asn5061

Other Protein References for SSPO Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for SSPO Gene

UniProtKB/Swiss-Prot:

SSPO_HUMAN
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.:
    • A2VEC9
  • Contains 2 EGF-like domains.:
    • A2VEC9
  • Contains 1 EMI domain.:
    • A2VEC9
  • Contains 1 F5/8 type C domain.:
    • A2VEC9
  • Contains 10 LDL-receptor class A domains.:
    • A2VEC9
  • Contains 6 TIL (trypsin inhibitory-like) domains.:
    • A2VEC9
  • Contains 24 TSP type-1 domains.:
    • A2VEC9
  • Contains 3 VWFC domains.:
    • A2VEC9
  • Contains 3 VWFD domains.:
    • A2VEC9
Family:
  • Belongs to the thrombospondin family.:
    • A2VEC9
genes like me logo Genes that share domains with SSPO: view

No data available for Gene Families for SSPO Gene

Function for SSPO Gene

Molecular function for SSPO Gene

UniProtKB/Swiss-Prot Function: Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity).

Enzyme Numbers (IUBMB) for SSPO Gene

Gene Ontology (GO) - Molecular Function for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030414 peptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SSPO: view

Phenotypes for SSPO Gene

GenomeRNAi human phenotypes for SSPO:
genes like me logo Genes that share phenotypes with SSPO: view

miRNA for SSPO Gene

miRTarBase miRNAs that target SSPO

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for SSPO Gene

Localization for SSPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSPO Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSPO Gene COMPARTMENTS Subcellular localization image for SSPO gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 22261194
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with SSPO: view

Pathways for SSPO Gene

SuperPathways for SSPO Gene

No Data Available

Interacting Proteins for SSPO Gene

Selected Interacting proteins: A2VEC9-SSPO_HUMAN for SSPO Gene via I2D

Gene Ontology (GO) - Biological Process for SSPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007399 nervous system development IEA --
GO:0010466 negative regulation of peptidase activity IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with SSPO: view

No data available for Pathways by source for SSPO Gene

Transcripts for SSPO Gene

Unigene Clusters for SSPO Gene

SCO-spondin homolog (Bos taurus):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSPO Gene

No ASD Table

Relevant External Links for SSPO Gene

GeneLoc Exon Structure for
SSPO
ECgene alternative splicing isoforms for
SSPO

Expression for SSPO Gene

mRNA expression in normal human tissues for SSPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSPO Gene

This gene is overexpressed in Brain - Cerebellum (5.9) and Brain - Cerebellar Hemisphere (5.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SSPO Gene

SOURCE GeneReport for Unigene cluster for SSPO Gene Hs.632022

genes like me logo Genes that share expressions with SSPO: view

Orthologs for SSPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSPO 36
  • 98.44 (n)
  • 97.16 (a)
cow
(Bos Taurus)
Mammalia SSPO 36
  • 83.47 (n)
  • 80.15 (a)
dog
(Canis familiaris)
Mammalia SSPO 36
  • 83.67 (n)
  • 79.54 (a)
mouse
(Mus musculus)
Mammalia Sspo 36
  • 79.5 (n)
  • 76.18 (a)
Sspo 16
rat
(Rattus norvegicus)
Mammalia Sspo 36
  • 79.55 (n)
  • 76.45 (a)
chicken
(Gallus gallus)
Aves SSPO 36
  • 62.54 (n)
  • 53.89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497129 36
  • 57.42 (n)
  • 51.73 (a)
zebrafish
(Danio rerio)
Actinopterygii scospondin 36
  • 52.3 (n)
  • 44.44 (a)
Species with no ortholog for SSPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSPO Gene

ENSEMBL:
Gene Tree for SSPO (if available)
TreeFam:
Gene Tree for SSPO (if available)

Paralogs for SSPO Gene

Selected SIMAP similar genes for SSPO Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSPO: view

No data available for Paralogs for SSPO Gene

Variants for SSPO Gene

Sequence variations from dbSNP and Humsavar for SSPO Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs709060 -, - 149,787,971(-) CTCAC(A/G)GCAGA missense, reference
rs732402 -- 149,792,772(+) CCTTG(A/G)CCCGC intron-variant
rs735499 -- 149,819,076(-) GGGCT(A/G)TGGAG intron-variant
rs737281 -- 149,833,581(+) GGGCA(C/T)GCGTG intron-variant
rs740108 -- 149,788,628(-) GACCC(C/T)GGCGG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for SSPO Gene

Variant ID Type Subtype PubMed ID
nsv469576 CNV Complex 16826518
nsv831184 CNV Gain 17160897
dgv2151e1 CNV Complex 17122850
dgv844n27 CNV Loss 19166990
dgv7529n71 CNV Loss 21882294
nsv517242 CNV Loss 19592680
dgv7530n71 CNV Loss 21882294
nsv521861 CNV Loss 19592680
nsv889409 CNV Loss 21882294
esv1010383 CNV Deletion 20482838
nsv824389 CNV Gain 20364138
esv1058616 CNV Deletion 17803354
esv2735334 CNV Deletion 23290073

Relevant External Links for SSPO Gene

HapMap Linkage Disequilibrium report
SSPO
Human Gene Mutation Database (HGMD)
SSPO

Disorders for SSPO Gene

Relevant External Links for SSPO

Genetic Association Database (GAD)
SSPO
Human Genome Epidemiology (HuGE) Navigator
SSPO
genes like me logo Genes that share disorders with SSPO: view

No data available for UniProtKB/Swiss-Prot for SSPO Gene

Publications for SSPO Gene

  1. Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth. (PMID: 11008217) Gobron S. … Meiniel A. (Glia 2000) 2 3 23
  2. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. (PMID: 17126404) Meiniel O. … Meiniel A. (Brain Res. Brain Res. Rev. 2007) 3 4 23
  3. The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines. (PMID: 14692680) Meiniel A. … Dastugue B. (Int. Rev. Cytol. 2003) 3 23
  4. Placental expression of SCO-spondin during mouse and human development. (PMID: 15053980) GonAsalves-Mendes N. … Sapin V. (Gene Expr. Patterns 2004) 3 23
  5. SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation. (PMID: 8743952) Gobron S. … Meiniel A. (J. Cell. Sci. 1996) 2 3

Products for SSPO Gene

Sources for SSPO Gene

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