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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSPN Gene

protein-coding   GIFtS: 54
GCID: GC12P026275

sarcospan

(Previous name: Kras oncogene-associated gene )
(Previous symbol: KRAG)
 Explore 14 diseases affiliated with
SSPN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SSPN    

Aliases
for SSPN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sarcospan1     DAGA52
KRAG1 2 3 5     NSPN2
SPN11 2     Kras Oncogene-Associated2
SPN21 2     Microspan1
Kirsten-Ras-Associated Protein2 3     Nanospan1
K-Ras Oncogene-Associated Protein2 3     Sarcospan (Kras Oncogene-Associated Gene)2
Kras Oncogene-Associated Gene1     

External Ids:    HGNC: 113221   Entrez Gene: 80822   Ensembl: ENSG000001230967   OMIM: 6015995   UniProtKB: Q147143   

Export aliases for SSPN gene to outside databases

Previous GC identifers: GC12P026709 GC12P026359 GC12P026248 GC12P026239 GC12P026348 GC12P026118


Summaries
for SSPN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SSPN:
This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised
of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between
the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript
variants that encode different protein isoforms have been described. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: SSPN_HUMAN, Q14714
Function: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and
forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the
sarcoglycan subcomplex of the DGC




Genomic Views
for SSPN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSPN gene promoter:
         S8   Zic1   LHX3a/Lhx3a   Cart-1   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSPN promoter sequence
   Search SABiosciences Chromatin IP Primers for SSPN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.2   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p11.2

SSPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSPN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P026275:  view genomic region     (about GC identifiers)

Start:
 26,274,924 bp from pter      End:
 26,452,223 bp from pter
Size:
 177,300 bases      Orientation:
 plus strand

Proteins
for SSPN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SSPN_HUMAN, Q14714 (See protein sequence)
Recommended Name: Sarcospan  
Size: 243 amino acids; 26618 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cell membrane, sarcolemma (By
similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity).
Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions (By similarity)
Alternative splicing: 2 isoforms:  Q14714-1   Q14714-2   

Explore the universe of human proteins at neXtProt for SSPN: NX_Q14714

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14714

    • SSPN Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129295.1  NP_005077.2  

    ENSEMBL proteins: 
     ENSP00000445360   ENSP00000442893   ENSP00000396087   ENSP00000242729   ENSP00000438801  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: SSPN
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    Novus Biologicals SSPN Protein
    Novus Biologicals SSPN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SSPN

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9395445
    GO:0016010dystrophin-associated glycoprotein complex TAS9395445
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--
    GO:0030133transport vesicle IDA--


    SSPN for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SSPN

    Protein Domains /
    Families
    for SSPN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SSPN for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q14714

    ProtoNet protein and cluster: Q14714


    Function
    for SSPN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SSPN_HUMAN, Q14714
    Function: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and
    forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the
    sarcoglycan subcomplex of the DGC

         Genatlas biochemistry entry for SSPN:
    sarcospan,dystrophin associated glycoprotein,25kDa,expressed and spanning in the sarcolemma,complexing with
    sarcoglycans in a stoichiometrically equal complex,expressed in skeletal muscle and in vascular smooth
    muscle,stabilizing the link between dystroglycan and dystrophin/utrophin

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSPN
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate SSPN (see all 67):
    hsa-miR-411* hsa-miR-579 hsa-miR-1321 hsa-miR-607 hsa-miR-374a hsa-miR-10b* hsa-miR-508-5p hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmid: SSPN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSPN (see all 7)
    OriGene shRNA RFP: SSPN
    OriGene siRNA: SSPN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSPN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SSPN

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSPN (see all 4)
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    GenScript: all cDNA clones in your preferred vector (see all 2): SSPN (NM_005086)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSPN 

    Cell Line
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    Search LifeMap BioReagents cell lines for SSPN

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPN

    1 GenomeRNAi human phenotype for SSPN:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Sspntm1Kcam for SSPN
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sspn):
     growth/size  homeostasis/metabolism  mortality/aging  muscle  skeleton 

    SSPN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SSPN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Muscular Dystrophies and Dystrophin-Glycoprotein Complex
    		Muscular Dystrophies and Dystrophin-Glycoprotein Complex1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SSPN
        Muscular Dystrophies and Dystrophin-Glycoprotein Complex


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSPN

    1 Interacting protein for SSPN (Q147143) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGCGQ133263I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS9395445
    GO:0007155cell adhesion TAS9395445


    SSPN for ontologies           About GeneDecksing



    Drugs & Compounds
    for SSPN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSPN
    Search CenterWatch for drugs/clinical trials and news about SSPN 

    Transcripts
    for SSPN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SSPN gene (2 alternative transcripts): 
    NM_001135823.1  NM_005086.4  

    Unigene Cluster for SSPN:

    Sarcospan
    Hs.183428  [show with all ESTs]
    Unigene Representative Sequence: NM_005086
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538142 ENST00000534829 ENST00000539019(uc001rhc.3) ENST00000540266
    ENST00000422622(uc001rhd.3) ENST00000544231 ENST00000242729(uc001rhe.3 uc009zjf.2 uc001rhf.3)
    ENST00000535504

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSPN
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate SSPN (see all 67):
    hsa-miR-411* hsa-miR-579 hsa-miR-1321 hsa-miR-607 hsa-miR-374a hsa-miR-10b* hsa-miR-508-5p hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmid: SSPN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSPN (see all 7)
    OriGene shRNA RFP: SSPN
    OriGene siRNA: SSPN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSPN
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSPN (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SSPN (NM_005086)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSPN 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSPN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSPN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSPN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSPN

    Additional cDNA sequence: 

    AF016028.2 AK092925.1 AK304667.1 AK314353.1 AL122041.1 AL136756.1 BC062299.1 DQ897666.1 
    EU433933.1 X89105.1 

    11 DOTS entries:

    DT.91976177  DT.95154373  DT.415231  DT.121206112  DT.121205996  DT.121206130  DT.121206144  DT.95156737 
    DT.214729  DT.75119332  DT.91641341 

    24/138 AceView cDNA sequences (see all 138):

    BP374200 AF016028 BC062299 AL136756 AW089160 BQ446900 AA992186 H88605 
    AA317228 AA620859 BQ889590 AA044120 BM713828 R72445 X89105 AA922282 
    NM_005086 AI014931 H88606 R14535 N53732 AA569999 BP374291 AI769110 

    GeneLoc Exon Structure


    Expression
    for SSPN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGAGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SSPN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    HeartAtrioventricular NodeAtrioventricular Node CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    Genevestigator expression for SSPN

    SOURCE GeneReport for Unigene cluster: Hs.183428

    UniProtKB/Swiss-Prot: SSPN_HUMAN, Q14714
    Tissue specificity: Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart,
    skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen

        SABiosciences Custom PCR Arrays for SSPN
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSPN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPN

    Orthologs
    for SSPN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SSPN gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sspn1 , 5 sarcospan1, 5 83.41(n)1
    84.98(a)1    		   6 (77.70 cM)5
    166511  NM_010656.21  NP_034786.11 
     1459316415 
    chicken
    (Gallus gallus)    		 Aves SSPN1 sarcospan (Kras oncogene-associated gene) 71.18(n)
    67.76(a)    		   418211  XM_416438.3  XP_416438.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SSPN6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 5(90723912-90734871)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.289362 Xenopus laevis transcribed sequence with weak similarity more 74.83(n)    CD362597.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sspn1 sarcospan (Kras oncogene-associated gene) 55.97(n)
    45.06(a)    		   641583  NM_001037580.1  NP_001032669.1 


    ENSEMBL Gene Tree for SSPN (if available)
    TreeFam Gene Tree for SSPN (if available) 

    Paralogs
    for SSPN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SSPN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/699 NCBI SNPs in SSPN are shown (see all 699)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs614253381,2
    		C,F,--26116397(+) GTCAAT/ATGACT 1 -- us2k13Minor allele frequency- A:0.21WA 122
    rs169303251,2
    		C,--26116721(+) TCCAGA/GTGGAA 2 -- us2k1 tfbs34Minor allele frequency- G:0.03NA WA 260
    rs772633261,2
    		F,--26116774(+) AAGTAC/TATACT 2 -- us2k11Minor allele frequency- T:0.03NA 120
    rs347538091,2
    		C,F,--26117199(+) AAATAT/CTGACT 2 -- us2k15Minor allele frequency- C:0.05NA EA 246
    rs1155179011,2
    		C,F,--26117275(+) GAAGAC/ATAACT 2 -- us2k11Minor allele frequency- A:0.04WA 118
    rs740750371,2
    		C,--26118185(+) GTTTTG/AAGTGA 2 -- us2k12Minor allele frequency- A:0.14WA 120
    rs79794411,2
    		C,--26118879(+) GAAGTC/GGCATG 2 -- int12Minor allele frequency- G:0.04CSA WA 120
    rs786766351,2
    		C,F,--26119380(+) ATCCAC/ATGGAG 2 -- int11Minor allele frequency- A:0.03WA 118
    rs743776251,2
    		F,--26119499(+) GAAACA/GTGTAG 2 -- int11Minor allele frequency- G:0.03EA 120
    rs596314571,2
    		C,F,--26119644(+) TAATCA/GTTCTC 2 -- int12Minor allele frequency- G:0.11WA NA 238

    HapMap Linkage Disequilibrium report for SSPN (26274924 - 26452223 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SSPN: --
    Locus Specific Mutation Databases (LSDB): SSPN

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSPN
    DNA2.0 Custom Variant and Variant Library Synthesis for SSPN

    Disorders / Diseases
    for SSPN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SSPN for disorders           About GeneDecksing

    OMIM gene information: 601599    OMIM disorders: --

    14 diseases for SSPN:    About MalaCards
    fukuyama congenital muscular dystrophy    congenital muscular dystrophy    muscular dystrophy    sarcoglycanopathies
    filariasis    adrenal carcinoma    gastritis    lung adenocarcinoma
    gastric cancer    colorectal cancer    lung cancer    adenocarcinoma
    carcinoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SSPN:
    Muscular dystrophy
    Genetic Association Database (GAD): SSPN
    Human Genome Epidemiology (HuGE) Navigator: SSPN (7 documents)

    Export disorders for SSPN gene to outside databases

    Publications
    for SSPN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSPN gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SSPN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG. (PubMed id 8661122)1, 2, 3, 9 Heighway J.... Cowen R. (1996)
    2. Sarcospan, the 25-kDa transmembrane component of the dystrophin- glycoprotein complex. (PubMed id 9395445)1, 2, 3 Crosbie R.H.... Campbell K.P. (1997)
    3. Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms. (PubMed id 15375499)1, 4 Noda N....Shirakusa T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer. (PubMed id 11807778)1, 4 Hiyama T....Chayama K. (2002)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers. (PubMed id 11470766)1, 4 Matsuzoe D....Kimura A. (2001)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distr ibution. (PubMed id 20935629)1 Heid I.M....Lindgren C.M. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)

    External Searches for SSPN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SSPN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8082 HGNC: 11322 AceView: SSPN Ensembl:ENSG00000123096 euGenes: HUgn8082
    ECgene: SSPN H-InvDB: SSPN

    Other Databases showing SSPN gene

    (According to HUGE)
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    Specialized Databases showing SSPN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSPN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSPN Genetics and Cytogenetics in Oncology and Haematology
    LEIDEN Muscular Dystrophy page for SSPN Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.

    Intellectual Property
    for SSPN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
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    		Patent Information for SSPN gene:
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