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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSPN Gene

protein-coding   GIFtS: 54
GCID: GC12P026275

Sarcospan

(Previous name: Kras oncogene-associated gene)
(Previous symbol: KRAG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
sarcospan1 2     SPN12
KRAG1 2 3 5     SPN22
Kirsten-Ras-Associated Protein2 3     Kras Oncogene-Associated2
K-Ras Oncogene-Associated Protein2 3     microspan2
Kras Oncogene-Associated Gene1     nanospan2
DAGA52     Sarcospan (Kras Oncogene-Associated Gene)2
NSPN2     

External Ids:    HGNC: 113221   Entrez Gene: 80822   Ensembl: ENSG000001230967   OMIM: 6015995   UniProtKB: Q147143   

Export aliases for SSPN gene to outside databases

Previous GC identifers: GC12P026709 GC12P026359 GC12P026248 GC12P026239 GC12P026348 GC12P026118


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSPN Gene:
This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is
comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a
structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two
alternatively spliced transcript variants that encode different protein isoforms have been described. (provided
by RefSeq, Oct 2008)

GeneCards Summary for SSPN Gene: 
SSPN (sarcospan) is a protein-coding gene. Diseases associated with SSPN include adrenal carcinoma, and sarcoglycanopathies.

UniProtKB/Swiss-Prot: SSPN_HUMAN, Q14714
Function: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane
and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with
the sarcoglycan subcomplex of the DGC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSPN gene promoter:
         S8   Zic1   LHX3a/Lhx3a   Cart-1   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SSPN promoter sequence
   Search SABiosciences Chromatin IP Primers for SSPN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.2   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p11.2

SSPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSPN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P026275:  view genomic region     (about GC identifiers)

Start:
26,274,924 bp from pter      End:
26,452,223 bp from pter
Size:
177,300 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSPN_HUMAN, Q14714 (See protein sequence)
Recommended Name: Sarcospan  
Size: 243 amino acids; 26618 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity). Cell membrane, sarcolemma (By
similarity). Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein (By similarity).
Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions (By
similarity)
Secondary accessions: B3KS67
Alternative splicing: 3 isoforms:  Q14714-1   Q14714-2   Q14714-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSPN: NX_Q14714

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14714

  • SSPN Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129295.1  NP_005077.2  

    ENSEMBL proteins: 
     ENSP00000445360   ENSP00000442893   ENSP00000396087   ENSP00000242729   ENSP00000438801  

    Human Recombinant Protein Products for SSPN: 
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    Cloud-Clone Corp. Proteins for SSPN 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9395445
    GO:0016010dystrophin-associated glycoprotein complex TAS9395445
    GO:0016021integral to membrane ----
    GO:0030054cell junction IEA--
    GO:0030133transport vesicle IDA--

    SSPN for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007237 CD20-like

    Graphical View of Domain Structure for InterPro Entry Q14714

    ProtoNet protein and cluster: Q14714


    SSPN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSPN_HUMAN, Q14714
    Function: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane
    and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with
    the sarcoglycan subcomplex of the DGC

         Genatlas biochemistry entry for SSPN:
    sarcospan,dystrophin associated glycoprotein,25kDa,expressed and spanning in the sarcolemma,complexing with
    sarcoglycans in a stoichiometrically equal complex,expressed in skeletal muscle and in vascular smooth
    muscle,stabilizing the link between dystroglycan and dystrophin/utrophin

    Phenotypes:
         1 GenomeRNAi human phenotype for SSPN:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sspn):
     growth/size  homeostasis/metabolism  mortality/aging  muscle  skeleton 

    SSPN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sspntm1Kcam for SSPN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSPN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSPN

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    miRNA
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    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate SSPN (see all 67):
    hsa-miR-411* hsa-miR-579 hsa-miR-1321 hsa-miR-607 hsa-miR-374a hsa-miR-10b* hsa-miR-508-5p hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidSSPN 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSPN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Muscular Dystrophies and Dystrophin-Glycoprotein Complex
    Muscular Dystrophies and Dystrophin-Glycoprotein Complex

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SSPN
        Muscular Dystrophies and Dystrophin-Glycoprotein Complex


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSPN

    1 Interacting protein for SSPN (Q147143) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGCGQ133263I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction TAS9395445
    GO:0007155cell adhesion TAS9395445

    SSPN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSPN

    Search CenterWatch for drugs/clinical trials and news about SSPN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSPN gene (2 alternative transcripts): 
    NM_001135823.1  NM_005086.4  

    Unigene Cluster for SSPN:

    Sarcospan
    Hs.183428  [show with all ESTs]
    Unigene Representative Sequence: NM_005086
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000538142 ENST00000534829 ENST00000539019(uc001rhc.3) ENST00000540266
    ENST00000422622(uc001rhd.3) ENST00000544231 ENST00000242729(uc001rhe.3 uc009zjf.2 uc001rhf.3)
    ENST00000535504
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSPN
    8/67 QIAGEN miScript miRNA Assays for microRNAs that regulate SSPN (see all 67):
    hsa-miR-411* hsa-miR-579 hsa-miR-1321 hsa-miR-607 hsa-miR-374a hsa-miR-10b* hsa-miR-508-5p hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidSSPN 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Clone
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    OriGene ORF clones in mouse, rat for SSPN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SSPN (NM_005086)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSPN
    Sirion Biotech Customized lentivirus for stable overexpression of SSPN 
                         Customized lentivirus expression plasmids for stable overexpression of SSPN 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSPN

    Additional mRNA sequence: 

    AF016028.2 AK092925.1 AK304667.1 AK314353.1 AL122041.1 AL136756.1 BC062299.1 DQ897666.1 
    EU433933.1 X89105.1 

    11 DOTS entries:

    DT.91976177  DT.95154373  DT.415231  DT.121206112  DT.121205996  DT.121206130  DT.121206144  DT.95156737 
    DT.214729  DT.75119332  DT.91641341 

    24/138 AceView cDNA sequences (see all 138):

    AI014931 NM_005086 AA922282 BM713828 R72445 X89105 BQ889590 AA044120 
    AA620859 AA317228 H88605 AA992186 BQ446900 BC062299 AL136756 AW089160 
    AA569999 N53732 R14535 H88606 AF016028 BP374200 BP374291 AI955597 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSPN expression in normal human tissues (normalized intensities)      SSPN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAGGTGG
    SSPN Expression
    About this image


    SSPN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Normal Human Articular chondrocytes (NHAC)   
     
     Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 2 entries
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Fibroblast
             BH2 Dermal Fibroblasts   

    Genevestigator expression for SSPN

    SOURCE GeneReport for Unigene cluster: Hs.183428

    UniProtKB/Swiss-Prot: SSPN_HUMAN, Q14714
    Tissue specificity: Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in
    heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen

        SABiosciences Custom PCR Arrays for SSPN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSPN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SSPN gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sspn1 , 5 sarcospan1, 5 83.41(n)1
    84.98(a)1
      6 (77.70 cM)5
    166511  NM_010656.21  NP_034786.11 
     1459316415 
    chicken
    (Gallus gallus)
    Aves SSPN1 sarcospan (Kras oncogene-associated gene) 71.18(n)
    67.76(a)
      418211  XM_416438.3  XP_416438.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSPN6
    Uncharacterized protein
    63(a)
    1 ↔ 1
    5(90723819-90734871)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.289362 Xenopus laevis transcribed sequence with weak similarity more 74.83(n)    CD362597.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sspn1 sarcospan (Kras oncogene-associated gene) 55.97(n)
    45.06(a)
      641583  NM_001037580.1  NP_001032669.1 


    ENSEMBL Gene Tree for SSPN (if available)
    TreeFam Gene Tree for SSPN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSPN gene
    1 SIMAP similar gene for SSPN using alignment to 3 protein entries:     SSPN_HUMAN (see all proteins):
    NSPN

    SSPN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/837 SNPs in SSPN are shown (see all 837)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs777943831,2
    C--26127378(+) CAAAG-/TATCT/TA
    TCTGATGCAAA
    GTGGC
    2 -- int10--------
    rs30823391,2
    C--26135984(+) TTTTT-/T/TT  
            
    CCAGA
    2 -- int1 trp30--------
    rs339809101,2
    C--26137749(+) AAAAA-/TACACA 2 -- int10--------
    rs753972451,2
    C--26143991(+) TCATTC/TCTCAG 2 -- int11Minor allele frequency- T:0.00NA 2
    rs1849753781,2
    --26215053(+) AATACA/TCAGTA 1 -- us2k10--------
    rs614253381,2
    C,F--26215110(+) GTCAAT/ATGACT 1 -- us2k13Minor allele frequency- A:0.21WA 122
    rs1416697141,2
    --26215398(+) TGTATC/TTGTTC 2 -- us2k10--------
    rs169303251,2
    C--26215434(+) TCCAGA/GTGGAA 2 -- us2k1 tfbs34Minor allele frequency- G:0.03NA WA 260
    rs772633261,2
    C,F--26215487(+) AAGTAC/TATACT 2 -- us2k11Minor allele frequency- T:0.03NA 120
    rs38091381,2
    C,F--26215609(-) TGCTAT/ATGGAA 2 -- us2k1 tfbs38Minor allele frequency- A:0.23NA WA EA 504

    HapMap Linkage Disequilibrium report for SSPN (26274924 - 26452223 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SSPN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv648CNV Loss18451855


    Locus Specific Mutation Databases (LSDB): SSPN
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SSPN
    DNA2.0 Custom Variant and Variant Library Synthesis for SSPN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601599    OMIM disorders: --

    13 diseases for SSPN:    About MalaCards
    adrenal carcinoma    sarcoglycanopathies    fukuyama congenital muscular dystrophy    filariasis
    congenital muscular dystrophy    muscular dystrophy    lung adenocarcinoma    gastritis
    gastric cancer    adenocarcinoma    colorectal cancer    lung cancer
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SSPN:
    Muscular dystrophy

    SSPN for disorders           About GeneDecksing

    Genetic Association Database (GAD): SSPN
    Human Genome Epidemiology (HuGE) Navigator: SSPN (7 documents)

    Export disorders for SSPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSPN gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with SSPN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG. (PubMed id 8661122)1, 2, 3, 9 Heighway J.... Cowen R. (1996)
    2. Sarcospan, the 25-kDa transmembrane component of the dystrophin- glycoprotein complex. (PubMed id 9395445)1, 2, 3 Crosbie R.H.... Campbell K.P. (1997)
    3. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distr ibution. (PubMed id 20935629)1, 4 Heid I.M....Lindgren C.M. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms. (PubMed id 15375499)1, 4 Noda N....Shirakusa T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer. (PubMed id 11807778)1, 4 Hiyama T....Chayama K. (2002)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    10. Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers. (PubMed id 11470766)1, 4 Matsuzoe D....Kimura A. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8082 HGNC: 11322 AceView: SSPN Ensembl:ENSG00000123096 euGenes: HUgn8082
    ECgene: SSPN H-InvDB: SSPN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSPN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SSPN Genetics and Cytogenetics in Oncology and Haematology
    LEIDEN Muscular Dystrophy page for SSPN Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSPN gene:
    Search GeneIP for patents involving SSPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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