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Aliases for SSPN Gene

Aliases for SSPN Gene

  • Sarcospan 2 3
  • KRAG 3 4 6
  • K-Ras Oncogene-Associated Protein 3 4
  • Kirsten-Ras-Associated Protein 3 4
  • Sarcospan (Kras Oncogene-Associated Gene) 3
  • Kras Oncogene-Associated Gene 2
  • Kras Oncogene-Associated 3
  • Microspan 3
  • Nanospan 3
  • DAGA5 3
  • SPN1 3
  • NSPN 3
  • SPN2 3

External Ids for SSPN Gene

Previous HGNC Symbols for SSPN Gene

  • KRAG

Previous GeneCards Identifiers for SSPN Gene

  • GC12P026709
  • GC12P026359
  • GC12P026248
  • GC12P026239
  • GC12P026348
  • GC12P026275

Summaries for SSPN Gene

Entrez Gene Summary for SSPN Gene

  • This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

GeneCards Summary for SSPN Gene

SSPN (Sarcospan) is a Protein Coding gene. Diseases associated with SSPN include adrenal carcinoma and sarcoglycanopathies. Among its related pathways are Muscular Dystrophies and Dystrophin-Glycoprotein Complex.

UniProtKB/Swiss-Prot for SSPN Gene

  • Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSPN Gene

Genomics for SSPN Gene

Regulatory Elements for SSPN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSPN Gene

Start:
26,121,991 bp from pter
End:
26,299,290 bp from pter
Size:
177,300 bases
Orientation:
Plus strand

Genomic View for SSPN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSPN Gene

Proteins for SSPN Gene

  • Protein details for SSPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14714-SSPN_HUMAN
    Recommended name:
    Sarcospan
    Protein Accession:
    Q14714
    Secondary Accessions:
    • B3KS67

    Protein attributes for SSPN Gene

    Size:
    243 amino acids
    Molecular mass:
    26618 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSPN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSPN Gene

Proteomics data for SSPN Gene at MOPED

Post-translational modifications for SSPN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSPN Gene

No data available for DME Specific Peptides for SSPN Gene

Domains for SSPN Gene

Protein Domains for SSPN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSPN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSPN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SSPN Gene

Function for SSPN Gene

Molecular function for SSPN Gene

GENATLAS Biochemistry: sarcospan,dystrophin associated glycoprotein,25kDa,expressed and spanning in the sarcolemma,complexing with sarcoglycans in a stoichiometrically equal complex,expressed in skeletal muscle and in vascular smooth muscle,stabilizing the link between dystroglycan and dystrophin/utrophin
UniProtKB/Swiss-Prot Function: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC
genes like me logo Genes that share phenotypes with SSPN: view

Animal Models for SSPN Gene

MGI Knock Outs for SSPN:

Animal Model Products

miRNA for SSPN Gene

miRTarBase miRNAs that target SSPN

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSPN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targeting and HOMER Transcription for SSPN Gene

Localization for SSPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSPN Gene

Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSPN Gene COMPARTMENTS Subcellular localization image for SSPN gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016010 dystrophin-associated glycoprotein complex IEA --
GO:0016021 integral component of membrane --
GO:0030054 cell junction IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with SSPN: view

Pathways for SSPN Gene

genes like me logo Genes that share pathways with SSPN: view

Pathways by source for SSPN Gene

Gene Ontology (GO) - Biological Process for SSPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction TAS 9395445
GO:0007155 cell adhesion TAS 9395445
genes like me logo Genes that share ontologies with SSPN: view

Transcripts for SSPN Gene

Unigene Clusters for SSPN Gene

Sarcospan:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSPN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSPN Gene

No ASD Table

Relevant External Links for SSPN Gene

GeneLoc Exon Structure for
SSPN
ECgene alternative splicing isoforms for
SSPN

Expression for SSPN Gene

mRNA expression in normal human tissues for SSPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSPN Gene

This gene is overexpressed in Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SSPN Gene

SOURCE GeneReport for Unigene cluster for SSPN Gene Hs.183428

mRNA Expression by UniProt/SwissProt for SSPN Gene

Q14714-SSPN_HUMAN
Tissue specificity: Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen
genes like me logo Genes that share expressions with SSPN: view

In Situ Assay Products

Orthologs for SSPN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSPN 35
  • 99.18 (n)
  • 99.59 (a)
SSPN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSPN 35
  • 88.43 (n)
  • 88.02 (a)
SSPN 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSPN 35
  • 89.3 (n)
  • 91.16 (a)
SSPN 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sspn 35
  • 83.41 (n)
  • 84.98 (a)
Sspn 16
Sspn 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSPN 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSPN 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sspn 35
  • 84.81 (n)
  • 85.12 (a)
chicken
(Gallus gallus)
Aves SSPN 35
  • 68.46 (n)
  • 62.81 (a)
SSPN 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSPN 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28936 35
zebrafish
(Danio rerio)
Actinopterygii sspn 35
  • 56.41 (n)
  • 45.51 (a)
sspn 36
  • 46 (a)
OneToOne
Species with no ortholog for SSPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSPN Gene

ENSEMBL:
Gene Tree for SSPN (if available)
TreeFam:
Gene Tree for SSPN (if available)

Paralogs for SSPN Gene

Selected SIMAP similar genes for SSPN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SSPN: view

No data available for Paralogs for SSPN Gene

Variants for SSPN Gene

Sequence variations from dbSNP and Humsavar for SSPN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7470 -- 26,234,510(+) CATTC(A/G)TTTGG utr-variant-3-prime
rs9214 -- 26,232,853(+) TGGAG(A/C)AGAAT utr-variant-3-prime
rs9850 -- 26,232,706(+) ATTGT(A/G)AATAT utr-variant-3-prime
rs1009766 -- 26,202,582(-) AAACC(C/T)ATGCC intron-variant
rs1060086 -- 26,232,418(+) AAGGA(A/G)GGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SSPN Gene

Variant ID Type Subtype PubMed ID
nsv648 CNV Loss 18451855

Relevant External Links for SSPN Gene

HapMap Linkage Disequilibrium report
SSPN
Locus Specific Mutation Databases (LSDB)
SSPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSPN Gene

Disorders for SSPN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SSPN Gene including...

Search for SSPN Gene in MalaCards »

(1) University of Copenhagen DISEASES for SSPN Gene

Relevant External Links for SSPN

Genetic Association Database (GAD)
SSPN
Human Genome Epidemiology (HuGE) Navigator
SSPN
genes like me logo Genes that share disorders with SSPN: view

No data available for UniProtKB/Swiss-Prot for SSPN Gene

Publications for SSPN Gene

  1. Coamplification in tumors of KRAS2, type 2 inositol 1,4,5 triphosphate receptor gene, and a novel human gene, KRAG. (PMID: 8661122) Heighway J. … Cowen R. (Genomics 1996) 2 3 4 23
  2. Sarcospan, the 25-kDa transmembrane component of the dystrophin- glycoprotein complex. (PMID: 9395445) Crosbie R.H. … Campbell K.P. (J. Biol. Chem. 1997) 2 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms. (PMID: 15375499) Noda N. … Shirakusa T. (Oncol. Rep. 2004) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SSPN Gene

Sources for SSPN Gene

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