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Aliases for SSNA1 Gene

Aliases for SSNA1 Gene

  • SS Nuclear Autoantigen 1 2 3 5
  • Sjogrens Syndrome Nuclear Autoantigen 1 2 3
  • Sjogren Syndrome Nuclear Autoantigen 1 2 3
  • Nuclear Autoantigen Of 14 KDa 3 4
  • NA14 3 4
  • Sjoegren Syndrome Nuclear Autoantigen 1 3
  • NA-14 3
  • N14 3

External Ids for SSNA1 Gene

Previous GeneCards Identifiers for SSNA1 Gene

  • GC00U990442
  • GC09P131773
  • GC09P133524
  • GC09P135440
  • GC09P137358
  • GC09P139202
  • GC09P140083
  • GC09P109543

Summaries for SSNA1 Gene

GeneCards Summary for SSNA1 Gene

SSNA1 (SS Nuclear Autoantigen 1) is a Protein Coding gene. Diseases associated with SSNA1 include Sjogren's Syndrome and Paralytic Squint. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include identical protein binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSNA1 Gene

Genomics for SSNA1 Gene

Regulatory Elements for SSNA1 Gene

Enhancers for SSNA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G136881 1.6 Ensembl ENCODE dbSUPER 10.3 -305.9 -305940 2.7 HDGF PKNOX1 FOXA2 MLX AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 PHPT1 MAMDC4 C9orf172 TMEM141 LCN12 PRR31 FBXW5 C8G RABL6 C9orf139
GH09G136884 1.3 ENCODE dbSUPER 10.3 -302.3 -302328 3.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B ZNF207 ZNF143 FOS PHPT1 SNHG7 MAMDC4 C9orf172 FBXW5 C8G LCN12 TMEM141 PRR31 CCDC183-AS1
GH09G137160 1 Ensembl ENCODE 12.7 -25.2 -25203 5.3 CTCF KLF1 SUZ12 RBBP5 RAD21 GLIS2 POLR2A KLF8 EZH2 PHF8 DPP7 SSNA1 ANAPC2 TPRN GRIN1 MAN1B1 NDOR1 TMEM203 NPDC1 EXD3
GH09G137187 1.4 ENCODE dbSUPER 8.3 +1.0 1029 4.3 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 DPH7 SSNA1 TPRN PIR44674 PIR49240
GH09G137193 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +9.8 9847 9.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 NDOR1 SSNA1 LCNL1 ABCA2 TPRN PNPLA7 C8G PIR49240 PIR44674
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSNA1 on UCSC Golden Path with GeneCards custom track

Promoters for SSNA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243154 198 1601 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Transcription factor binding sites by QIAGEN in the SSNA1 gene promoter:

Genomic Location for SSNA1 Gene

Chromosome:
9
Start:
137,188,602 bp from pter
End:
137,190,370 bp from pter
Size:
1,769 bases
Orientation:
Plus strand

Genomic View for SSNA1 Gene

Genes around SSNA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSNA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSNA1 Gene

Proteins for SSNA1 Gene

  • Protein details for SSNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43805-SSNA1_HUMAN
    Recommended name:
    Sjoegren syndrome nuclear autoantigen 1
    Protein Accession:
    O43805
    Secondary Accessions:
    • Q5VSG0
    • Q6FG70
    • Q9BVW8

    Protein attributes for SSNA1 Gene

    Size:
    119 amino acids
    Molecular mass:
    13596 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSNA1 Gene

Post-translational modifications for SSNA1 Gene

  • Ubiquitination at posLast=9797
  • Modification sites at PhosphoSitePlus

Other Protein References for SSNA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSNA1 Gene

Domains & Families for SSNA1 Gene

Protein Domains for SSNA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSNA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43805

UniProtKB/Swiss-Prot:

SSNA1_HUMAN :
  • Belongs to the SSNA1 family.
Family:
  • Belongs to the SSNA1 family.
genes like me logo Genes that share domains with SSNA1: view

No data available for Gene Families for SSNA1 Gene

Function for SSNA1 Gene

Gene Ontology (GO) - Molecular Function for SSNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 21516116
genes like me logo Genes that share ontologies with SSNA1: view
genes like me logo Genes that share phenotypes with SSNA1: view

Animal Model Products

CRISPR Products

miRNA for SSNA1 Gene

miRTarBase miRNAs that target SSNA1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSNA1 Gene

Localization for SSNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSNA1 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSNA1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SSNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SSNA1: view

Pathways & Interactions for SSNA1 Gene

genes like me logo Genes that share pathways with SSNA1: view

Gene Ontology (GO) - Biological Process for SSNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0042073 intraciliary transport IEA --
GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway IEA --
GO:0097711 ciliary basal body docking TAS --
genes like me logo Genes that share ontologies with SSNA1: view

No data available for SIGNOR curated interactions for SSNA1 Gene

Drugs & Compounds for SSNA1 Gene

No Compound Related Data Available

Transcripts for SSNA1 Gene

Unigene Clusters for SSNA1 Gene

Sjogren syndrome nuclear autoantigen 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSNA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for SSNA1 Gene

GeneLoc Exon Structure for
SSNA1
ECgene alternative splicing isoforms for
SSNA1

Expression for SSNA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSNA1 Gene

Protein differential expression in normal tissues from HIPED for SSNA1 Gene

This gene is overexpressed in Bone (53.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSNA1 Gene



Protein tissue co-expression partners for SSNA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSNA1 Gene:

SSNA1

SOURCE GeneReport for Unigene cluster for SSNA1 Gene:

Hs.530314

mRNA Expression by UniProt/SwissProt for SSNA1 Gene:

O43805-SSNA1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for SSNA1 Gene

  • Blood(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with SSNA1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSNA1 Gene

Orthologs for SSNA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSNA1 34 35
  • 98.6 (n)
oppossum
(Monodelphis domestica)
Mammalia SSNA1 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSNA1 34 35
  • 90.2 (n)
dog
(Canis familiaris)
Mammalia SSNA1 34 35
  • 90.2 (n)
mouse
(Mus musculus)
Mammalia Ssna1 34 16 35
  • 90.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSNA1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC771190 34
  • 61.95 (n)
lizard
(Anolis carolinensis)
Reptilia SSNA1 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssna1 34
  • 77.57 (n)
Str.5896 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8082 34
zebrafish
(Danio rerio)
Actinopterygii ssna1 34 35
  • 73.09 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1544 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2900 34
Species where no ortholog for SSNA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSNA1 Gene

ENSEMBL:
Gene Tree for SSNA1 (if available)
TreeFam:
Gene Tree for SSNA1 (if available)

Paralogs for SSNA1 Gene

(1) SIMAP similar genes for SSNA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSNA1: view

No data available for Paralogs for SSNA1 Gene

Variants for SSNA1 Gene

Sequence variations from dbSNP and Humsavar for SSNA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036343 A breast cancer sample
rs1000411549 -- 137,190,156(+) TGCAA(A/G)GGGCT upstream-variant-2KB, utr-variant-3-prime
rs1001970198 -- 137,189,410(+) CCAGG(A/C)CCATT intron-variant, upstream-variant-2KB
rs1002272841 -- 137,188,340(+) TGAAC(A/C)CGAGG intron-variant, upstream-variant-2KB
rs1002816602 -- 137,190,674(+) AGGAC(C/T)CAGCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SSNA1 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2761561 CNV gain 21179565
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for SSNA1 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSNA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSNA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSNA1 Gene

Disorders for SSNA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SSNA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
paralytic squint
  • incomitant dissociation
- elite association - COSMIC cancer census association via MalaCards
Search SSNA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSNA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSNA1
genes like me logo Genes that share disorders with SSNA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSNA1 Gene

Publications for SSNA1 Gene

  1. NA14 is a novel nuclear autoantigen with a coiled-coil domain. (PMID: 9430706) Ramos-Morales F. … Rios R.M. (J. Biol. Chem. 1998) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 3 4 64
  4. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K. … Roepman R. (Nat Commun 2016) 3 64

Products for SSNA1 Gene

Sources for SSNA1 Gene

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