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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSNA1 Gene

protein-coding   GIFtS: 53
GCID: GC09P140083

Sjogren Syndrome Nuclear Autoantigen 1

(Previous name: Sjogren's syndrome nuclear autoantigen 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sjogren Syndrome Nuclear Autoantigen 11 2     N142
NA142 3 5     NA-142
Sjogren'S Syndrome Nuclear Autoantigen 11 2     Sjoegren Syndrome Nuclear Autoantigen 12
Nuclear Autoantigen Of 14 KDa2 3     

External Ids:    HGNC: 113211   Entrez Gene: 86362   Ensembl: ENSG000001761017   OMIM: 6108825   UniProtKB: O438053   

Export aliases for SSNA1 gene to outside databases

Previous GC identifers: GC00U990442 GC09P131773 GC09P133524 GC09P135440 GC09P137358 GC09P139202 GC09P109543


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SSNA1 Gene: 
SSNA1 (Sjogren syndrome nuclear autoantigen 1) is a protein-coding gene. Diseases associated with SSNA1 include paralytic squint, and sjogren's syndrome, and among its related super-pathways are G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_024000.16  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSNA1 gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSNA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSNA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSNA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

SSNA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSNA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140083:  view genomic region     (about GC identifiers)

Start:
140,083,054 bp from pter      End:
140,084,822 bp from pter
Size:
1,769 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSNA1_HUMAN, O43805 (See protein sequence)
Recommended Name: Sjoegren syndrome nuclear autoantigen 1  
Size: 119 amino acids; 13596 Da
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Secondary accessions: Q5VSG0 Q6FG70 Q9BVW8

Explore the universe of human proteins at neXtProt for SSNA1: NX_O43805

Explore proteomics data for SSNA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43805

  • SSNA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSNA1 Protein Expression
    REFSEQ proteins: NP_003722.2  
    ENSEMBL proteins: 
     ENSP00000313752  
    Reactome Protein details: O43805
    Human Recombinant Protein Products for SSNA1: 
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    Cloud-Clone Corp. Proteins for SSNA1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--

    SSNA1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: O43805

    UniProtKB/Swiss-Prot: SSNA1_HUMAN, O43805
    Similarity: Belongs to the SSNA1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042802identical protein binding IEA--
         
    SSNA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SSNA1:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSNA1 
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    miRTarBase miRNAs that target SSNA1:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSNA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for SSNA1 (see all 8)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    G2/M Transition
    Loss of proteins required for interphase microtubule organization,from the centrosome



    SSNA1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSNA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for SSNA1 (O438053 ENSP000003137524) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPASTQ9UBP03, ENSP000003208854I2D: score=1 STRING: ENSP00000320885
    SPATA2Q9UM823, ENSP000002894314I2D: score=2 STRING: ENSP00000289431
    CEP70ENSP000002649824STRING: ENSP00000264982
    DCTN2ENSP000004089104STRING: ENSP00000408910
    DCTN3ENSP000002596324STRING: ENSP00000259632
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0042073intraflagellar transport IEA--
    GO:0060830ciliary receptor clustering involved in smoothened signaling pathway IEA--

    SSNA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSNA1

    Search CenterWatch for drugs/clinical trials and news about SSNA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSNA1 gene: 
    NM_003731.2  

    Unigene Cluster for SSNA1:

    Sjogren syndrome nuclear autoantigen 1
    Hs.530314  [show with all ESTs]
    Unigene Representative Sequence: BM559272
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322310(uc004cls.2) ENST00000459860 ENST00000463511 ENST00000464553

    miRNA
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    Additional mRNA sequence: 

    BC000864.1 BC004118.2 BC015827.2 BT006766.1 CR542238.1 Z96932.1 

    7 DOTS entries:

    DT.95100744  DT.92433145  DT.100797483  DT.100797481  DT.92433146  DT.100797485  DT.40109073 

    24/226 AceView cDNA sequences (see all 226):

    AI745563 BQ672898 AI288565 AA360529 AI298942 BI826238 BQ776958 BE382943 
    BM993964 BC000864 AI085660 AU098405 AA359193 BM682004 BM796730 CR620508 
    BU538047 BM773159 BG773749 BM563563 BU167081 BE206518 BQ421136 CD365315 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SSNA1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
    SP1:                                                            
    SP2:                                -                           
    SP3:                                                            
    SP4:                                -                           


    ECgene alternative splicing isoforms for SSNA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSNA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCCCCCT
    SSNA1 Expression
    About this image


    See SSNA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSNA1

    SOURCE GeneReport for Unigene cluster: Hs.530314

    UniProtKB/Swiss-Prot: SSNA1_HUMAN, O43805
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSNA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SSNA1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssna11 , 5 Sjogren's syndrome nuclear autoantigen 11, 5 90.2(n)1
    97.48(a)1
      2 (17.12 cM)5
    684751  NM_023464.21  NP_075953.11 
     252710395 
    chicken
    (Gallus gallus)
    Aves SSNA11 Sjogren's syndrome nuclear autoantigen 1 63.1(n)
    62.5(a)
      420480  XM_001233636.2  XP_001233637.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSNA16
    Uncharacterized protein
    55(a)
    1 ↔ 1
    6(13883337-13883693)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80822 Xenopus laevis transcribed sequence with moderate similarity more 78.83(n)    BI477766.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ssna11 Sjogren syndrome nuclear autoantigen 1 73.09(n)
    78.9(a)
      561124  NM_001144793.1  NP_001138265.1 


    ENSEMBL Gene Tree for SSNA1 (if available)
    TreeFam Gene Tree for SSNA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSNA1 gene
    1 SIMAP similar gene for SSNA1 using alignment to 1 protein entry:     SSNA1_HUMAN:
    USP4

    SSNA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 SNPs in SSNA1 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363434
    A breast cancer sample4--see VAR_0363432 K N mis40--------
    rs600731161,2
    C,F--140085060(+) GCTCAC/ACCTCC 1 -- int16Minor allele frequency- A:0.25WA NA CSA 245
    rs727632891,2
    C,F--140085179(+) TCAGAT/CTCAGG 1 -- int18Minor allele frequency- C:0.19WA NA CSA EA 365
    rs727632901,2
    C,F--140085182(+) GATTCA/GGGTCC 1 -- int13Minor allele frequency- G:0.22NA WA 240
    rs675064371,2
    C,F--140085210(+) GGGGAG/CTTCAC 1 -- int19Minor allele frequency- C:0.24WA NA CSA EA 367
    rs735636721,2
    C--140085269(+) TGACAC/ACACTG 1 -- int12Minor allele frequency- A:0.07WA EA 122

    HapMap Linkage Disequilibrium report for SSNA1 (140083054 - 140084822 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for SSNA1 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422220CNV Deletion17116639
    dgv8416n71CNV Loss21882294
    dgv8439n71CNV Loss21882294
    dgv8445n71CNV Loss21882294
    dgv8441n71CNV Loss21882294
    dgv8428n71CNV Loss21882294
    nsv894521CNV Loss21882294
    dgv8450n71CNV Loss21882294
    dgv8423n71CNV Loss21882294
    dgv8451n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610882    OMIM disorders: --

    2 diseases for SSNA1:    About MalaCards
    paralytic squint    sjogren's syndrome

    1 disease from the University of Copenhagen DISEASES database for SSNA1:
    Paralytic squint

    SSNA1 for disorders           About GeneDecksing


    Export disorders for SSNA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSNA1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SSNA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NA14 is a novel nuclear autoantigen with a coiled-coil domain. (PubMed id 9430706)1, 2, 3 Ramos-Morales F.... Rios R.M. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2 Andersen J.S....Mann M. (2003)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function. (PubMed id 22008182)1 Rodriguez-Rodriguez M....Jimenez M.A. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8636 HGNC: 11321 AceView: SSNA1 Ensembl:ENSG00000176101 euGenes: HUgn8636
    ECgene: SSNA1 H-InvDB: SSNA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSNA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSNA1 gene:
    Search GeneIP for patents involving SSNA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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