SSNA1 Gene
protein-coding GIFtS: 50
GCID: GC09P140083
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Sjogren syndrome nuclear autoantigen 1(Previous name: Sjogren's syndrome nuclear autoantigen 1 )
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Aliases
for SSNA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sjogren Syndrome Nuclear Autoantigen 11 2 | | Nuclear Autoantigen Of 14 KDa2 3 | | NA141 2 3 5 | | NA-142 | | N141 2 | | Sjoegren Syndrome Nuclear Autoantigen 12 | | Sjogren'S Syndrome Nuclear Autoantigen 11 2 | | |
Export aliases for SSNA1 gene to outside databasesPrevious GC identifers: GC00U990442 GC09P131773 GC09P133524 GC09P135440 GC09P137358 GC09P139202 GC09P109543 |
Summaries
for SSNA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SSNA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_024000.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSNA1 gene promoter:
MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSNA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSNA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3SSNA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P140083: view genomic region
(about GC identifiers)
Start:
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140,083,054 bp from pter |
End:
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140,084,822 bp from pter |
Size:
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1,769 bases |
Orientation:
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plus strand |
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Proteins
for SSNA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSNA1_HUMAN, O43805 (See
protein sequence)Recommended Name: Sjoegren syndrome nuclear autoantigen 1 Size: 119 amino acids; 13596 Da
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome
Secondary accessions: Q5VSG0 Q6FG70 Q9BVW8Explore the universe of human proteins at neXtProt for SSNA1: NX_O43805
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43805
SSNA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003722.2
ENSEMBL proteins: ENSP00000313752 Reactome Protein details: O43805
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SSNA1 for ontologies About GeneDecksing
SSNA1 Antibody Products:
Assay Products for SSNA1: |
Protein
Domains /
Families
for SSNA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O43805 UniProtKB/Swiss-Prot: SSNA1_HUMAN, O43805Similarity: Belongs to the SSNA1 family |
Function
for SSNA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSNA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSNA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SSNA1 (NM_003731) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSNA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSNA1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042802 | identical protein binding |
IEA | -- |
SSNA1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SSNA1:
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Pathways & Interactions
for SSNA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for SSNA1 (see all 8)
SSNA1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSNA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for SSNA1 (O438053 ENSP000003137524) via UniProtKB, MINT, STRING, and/or I2D (see all 57)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000086 | G2/M transition of mitotic cell cycle |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- | | GO:0042073 | intraflagellar transport |
IEA | -- | | GO:0060830 | ciliary receptor clustering involved in smoothened signaling pathway |
IEA | -- |
SSNA1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSNA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSNA1
Search CenterWatch for drugs/clinical trials and news about SSNA1
|
Transcripts
for SSNA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSNA1 gene: NM_003731.2 Unigene Cluster for SSNA1: Sjogren syndrome nuclear autoantigen 1 Hs.530314 [show with all ESTs]Unigene Representative Sequence: BM5592724 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000322310(uc004cls.2) ENST00000459860 ENST00000463511 ENST00000464553
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSNA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSNA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SSNA1 (NM_003731) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSNA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSNA1 |
Additional cDNA sequence: BC000864.1 BC004118.2 BC015827.2 BT006766.1 CR542238.1 Z96932.1 7 DOTS entries: DT.95100744 DT.92433145 DT.100797483 DT.100797481 DT.92433146 DT.100797485 DT.40109073 24/226 AceView cDNA sequences (see all 226): CD365315 BQ421136 BE206518 BU538837 BF796457 BQ778139 BE793744 BC015827 AA373724 BF791853 AA827478 BE302202 AA357516 CA389973 AA325218 BQ440826 BF305440 AW629408 AI185088 AI085660 BC000864 BM682004 AA359193 AI298942
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SSNA1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d |
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for SSNA1
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Expression
for SSNA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSNA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGCCCCCT
About this image
See SSNA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSNA1
SOURCE GeneReport for Unigene cluster: Hs.530314
UniProtKB/Swiss-Prot: SSNA1_HUMAN, O43805Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for SSNA1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSNA1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSNA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSNA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSNA1 |
Orthologs
for SSNA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SSNA1 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for SSNA1 (if available)
TreeFam Gene Tree for SSNA1 (if available) |
Paralogs
for SSNA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SSNA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSNA1 (140083054 - 140084822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SSNA1
1 CNV: 5415 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSNA1 |
|
Disorders
/ Diseases
for SSNA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSNA1 for disorders About GeneDecksing
OMIM gene information: 610882
OMIM disorders: --
3  diseases for SSNA1: About MalaCardssjogren's syndrome paralytic squint malaria
1 disease from the University of Copenhagen DISEASES database for SSNA1:Paralytic squint Export disorders for SSNA1 gene to outside databases
|
Publications
for SSNA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSNA1 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with SSNA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NA14 is a novel nuclear autoantigen with a coiled-coil domain. (PubMed id 9430706)1, 2, 3 Ramos-Morales F.... Rios R.M. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2 Andersen J.S....Mann M. (2003)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Characterization of the structure and self-recognition of the human centrosomal protein NA14: implications for stability and function. (PubMed id 22008182)1 Rodriguez-Rodriguez M....Jimenez M.A. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
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External Searches for SSNA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SSNA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSNA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SSNA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SSNA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SSNA1 gene:
Search GeneIP for patents involving SSNA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSNA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SSNA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSNA1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSNA1 | | | OriGene Protein Over-expression Lysate for SSNA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SSNA1 | | OriGene 3'-UTR Clone for SSNA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSNA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSNA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SSNA1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SSNA1 | | OriGene Custom Protein Services for SSNA1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSNA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSNA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSNA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSNA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSNA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSNA1 |
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| | | | Search Tocris compounds for SSNA1 |
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 | | | SSNA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SSNA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSNA1 |
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