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Aliases for SSNA1 Gene

Aliases for SSNA1 Gene

  • Sjogren Syndrome Nuclear Autoantigen 1 2 3 5
  • Sjogrens Syndrome Nuclear Autoantigen 1 2 3
  • Nuclear Autoantigen Of 14 KDa 3 4
  • NA14 3 4
  • NA-14 3
  • N14 3

External Ids for SSNA1 Gene

Previous GeneCards Identifiers for SSNA1 Gene

  • GC00U990442
  • GC09P131773
  • GC09P133524
  • GC09P135440
  • GC09P137358
  • GC09P139202
  • GC09P140083
  • GC09P109543

Summaries for SSNA1 Gene

GeneCards Summary for SSNA1 Gene

SSNA1 (Sjogren Syndrome Nuclear Autoantigen 1) is a Protein Coding gene. Diseases associated with SSNA1 include sjogren's syndrome and paralytic squint. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance. GO annotations related to this gene include identical protein binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSNA1 Gene

Genomics for SSNA1 Gene

Regulatory Elements for SSNA1 Gene

Promoters for SSNA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSNA1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SSNA1 gene promoter:

Genomic Location for SSNA1 Gene

137,188,602 bp from pter
137,190,370 bp from pter
1,769 bases
Plus strand

Genomic View for SSNA1 Gene

Genes around SSNA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSNA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSNA1 Gene

Proteins for SSNA1 Gene

  • Protein details for SSNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sjoegren syndrome nuclear autoantigen 1
    Protein Accession:
    Secondary Accessions:
    • Q5VSG0
    • Q6FG70
    • Q9BVW8

    Protein attributes for SSNA1 Gene

    119 amino acids
    Molecular mass:
    13596 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSNA1 Gene

Proteomics data for SSNA1 Gene at MOPED

Post-translational modifications for SSNA1 Gene

  • Ubiquitination at Lys 97
  • Modification sites at PhosphoSitePlus

Other Protein References for SSNA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSNA1 Gene

Domains & Families for SSNA1 Gene

Protein Domains for SSNA1 Gene


Suggested Antigen Peptide Sequences for SSNA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SSNA1 family.
  • Belongs to the SSNA1 family.
genes like me logo Genes that share domains with SSNA1: view

No data available for Gene Families for SSNA1 Gene

Function for SSNA1 Gene

genes like me logo Genes that share phenotypes with SSNA1: view

Animal Model Products

miRNA for SSNA1 Gene

miRTarBase miRNAs that target SSNA1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSNA1 Gene

Localization for SSNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSNA1 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Jensen Localization Image for SSNA1 Gene COMPARTMENTS Subcellular localization image for SSNA1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for SSNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0036064 ciliary basal body IEA --
genes like me logo Genes that share ontologies with SSNA1: view

Pathways & Interactions for SSNA1 Gene

genes like me logo Genes that share pathways with SSNA1: view

Gene Ontology (GO) - Biological Process for SSNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with SSNA1: view

No data available for SIGNOR curated interactions for SSNA1 Gene

Drugs & Compounds for SSNA1 Gene

No Compound Related Data Available

Transcripts for SSNA1 Gene

Unigene Clusters for SSNA1 Gene

Sjogren syndrome nuclear autoantigen 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSNA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP2: -
SP4: -

Relevant External Links for SSNA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSNA1 Gene

mRNA expression in normal human tissues for SSNA1 Gene

Protein differential expression in normal tissues from HIPED for SSNA1 Gene

This gene is overexpressed in Bone (53.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSNA1 Gene

SOURCE GeneReport for Unigene cluster for SSNA1 Gene Hs.530314

mRNA Expression by UniProt/SwissProt for SSNA1 Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SSNA1: view

Protein tissue co-expression partners for SSNA1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SSNA1 Gene

Orthologs for SSNA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSNA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SSNA1 35
  • 90.2 (n)
  • 94.96 (a)
SSNA1 36
  • 94 (a)
(Canis familiaris)
Mammalia SSNA1 35
  • 90.2 (n)
  • 95.8 (a)
SSNA1 36
  • 90 (a)
(Mus musculus)
Mammalia Ssna1 35
  • 90.2 (n)
  • 97.48 (a)
Ssna1 16
Ssna1 36
  • 97 (a)
(Pan troglodytes)
Mammalia SSNA1 35
  • 98.6 (n)
  • 98.32 (a)
SSNA1 36
  • 97 (a)
(Monodelphis domestica)
Mammalia SSNA1 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia SSNA1 36
  • 76 (a)
(Gallus gallus)
Aves LOC771190 35
  • 61.95 (n)
  • 51.33 (a)
(Anolis carolinensis)
Reptilia SSNA1 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ssna1 35
  • 77.57 (n)
  • 80.37 (a)
Str.5896 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8082 35
(Danio rerio)
Actinopterygii ssna1 35
  • 73.09 (n)
  • 78.9 (a)
ssna1 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1544 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2900 35
Species with no ortholog for SSNA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSNA1 Gene

Gene Tree for SSNA1 (if available)
Gene Tree for SSNA1 (if available)

Paralogs for SSNA1 Gene

(1) SIMAP similar genes for SSNA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSNA1: view

No data available for Paralogs for SSNA1 Gene

Variants for SSNA1 Gene

Sequence variations from dbSNP and Humsavar for SSNA1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_036343 A breast cancer sample
rs60073116 -- 137,190,608(+) GCTCA(A/C)CCTCC downstream-variant-500B
rs72763289 -- 137,190,727(+) TCAGA(C/T)TCAGG downstream-variant-500B
rs72763290 -- 137,190,730(+) GATTC(A/G)GGTCC downstream-variant-500B
rs67506437 -- 137,190,758(+) GGGGA(C/G)TTCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SSNA1 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8439n71 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294

Variation tolerance for SSNA1 Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSNA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSNA1 Gene

Disorders for SSNA1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SSNA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
paralytic squint
  • incomitant dissociation
- elite association - COSMIC cancer census association via MalaCards
Search SSNA1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSNA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SSNA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSNA1 Gene

Publications for SSNA1 Gene

  1. NA14 is a novel nuclear autoantigen with a coiled-coil domain. (PMID: 9430706) Ramos-Morales F. … Rios R.M. (J. Biol. Chem. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development. (PMID: 25390646) Goyal U. … Blackstone C. (PLoS ONE 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for SSNA1 Gene

Sources for SSNA1 Gene

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