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Aliases for SSMEM1 Gene

Aliases for SSMEM1 Gene

  • Serine Rich Single-Pass Membrane Protein 1 2 3 5
  • C7orf45 3 4
  • Serine-Rich Single-Pass Membrane Protein 1 3
  • Chromosome 7 Open Reading Frame 45 2

External Ids for SSMEM1 Gene

Previous HGNC Symbols for SSMEM1 Gene

  • C7orf45

Previous GeneCards Identifiers for SSMEM1 Gene

  • GC07P129848

Summaries for SSMEM1 Gene

GeneCards Summary for SSMEM1 Gene

SSMEM1 (Serine Rich Single-Pass Membrane Protein 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSMEM1 Gene

Genomics for SSMEM1 Gene

Regulatory Elements for SSMEM1 Gene

Enhancers for SSMEM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F130203 1.1 ENCODE 0.8 -0.2 -209 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 TMEM209 ENSG00000243230 CDC26P1 SSMEM1 LOC105375502
GH07F130201 0.7 ENCODE 0.8 -3.3 -3314 1.3 BCOR HDGF PKNOX1 CBX3 ESRRA NR2F1 ZNF318 ZNF316 SMARCA4 PBX2 TMEM209 SSMEM1 LOC105375502
GH07F130180 0.5 ENCODE 0.3 -24.2 -24246 0.9 HLF CEBPB FOS KLHDC10 LOC105375502 SSMEM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSMEM1 on UCSC Golden Path with GeneCards custom track

Promoters for SSMEM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001563830 -203 1601 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SSMEM1 Gene

Chromosome:
7
Start:
130,205,403 bp from pter
End:
130,216,844 bp from pter
Size:
11,442 bases
Orientation:
Plus strand

Genomic View for SSMEM1 Gene

Genes around SSMEM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSMEM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSMEM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSMEM1 Gene

Proteins for SSMEM1 Gene

  • Protein details for SSMEM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWF3-SSMM1_HUMAN
    Recommended name:
    Serine-rich single-pass membrane protein 1
    Protein Accession:
    Q8WWF3

    Protein attributes for SSMEM1 Gene

    Size:
    244 amino acids
    Molecular mass:
    28167 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SSMEM1 Gene

Post-translational modifications for SSMEM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSMEM1 Gene

No data available for DME Specific Peptides for SSMEM1 Gene

Domains & Families for SSMEM1 Gene

Protein Domains for SSMEM1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSMEM1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SSMEM1 Gene

Function for SSMEM1 Gene

genes like me logo Genes that share phenotypes with SSMEM1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSMEM1 Gene

Localization for SSMEM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSMEM1 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSMEM1 gene
Compartment Confidence
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SSMEM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSMEM1: view

Pathways & Interactions for SSMEM1 Gene

SuperPathways for SSMEM1 Gene

No Data Available

Interacting Proteins for SSMEM1 Gene

Gene Ontology (GO) - Biological Process for SSMEM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SSMEM1 Gene

Transcripts for SSMEM1 Gene

mRNA/cDNA for SSMEM1 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSMEM1 Gene

Serine-rich single-pass membrane protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSMEM1 Gene

No ASD Table

Relevant External Links for SSMEM1 Gene

GeneLoc Exon Structure for
SSMEM1
ECgene alternative splicing isoforms for
SSMEM1

Expression for SSMEM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSMEM1 Gene

mRNA differential expression in normal tissues according to GTEx for SSMEM1 Gene

This gene is overexpressed in Testis (x50.4).

Protein differential expression in normal tissues from HIPED for SSMEM1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SSMEM1 Gene



Protein tissue co-expression partners for SSMEM1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSMEM1 Gene:

SSMEM1

SOURCE GeneReport for Unigene cluster for SSMEM1 Gene:

Hs.351816
genes like me logo Genes that share expression patterns with SSMEM1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SSMEM1 Gene

Orthologs for SSMEM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SSMEM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSMEM1 34 35
  • 98.06 (n)
dog
(Canis familiaris)
Mammalia SSMEM1 34 35
  • 85.79 (n)
cow
(Bos Taurus)
Mammalia SSMEM1 34
  • 84.79 (n)
MGC127766 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssmem1 34 16 35
  • 75.55 (n)
rat
(Rattus norvegicus)
Mammalia Ssmem1 34
  • 73.44 (n)
oppossum
(Monodelphis domestica)
Mammalia SSMEM1 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSMEM1 35
  • 47 (a)
OneToOne
Species where no ortholog for SSMEM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SSMEM1 Gene

ENSEMBL:
Gene Tree for SSMEM1 (if available)
TreeFam:
Gene Tree for SSMEM1 (if available)

Paralogs for SSMEM1 Gene

(1) SIMAP similar genes for SSMEM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SSMEM1: view

No data available for Paralogs for SSMEM1 Gene

Variants for SSMEM1 Gene

Sequence variations from dbSNP and Humsavar for SSMEM1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111683011 -- 130,206,847(+) AGGGC(A/G)TGGTG intron-variant, upstream-variant-2KB
rs111736608 -- 130,210,070(+) TGTCA(C/T)AAAAG intron-variant
rs111931380 -- 130,207,939(+) TTGGG(A/G)GGTAG intron-variant, upstream-variant-2KB, reference, missense
rs112472183 -- 130,216,636(+) CGTTC(-/A)AAAAA utr-variant-3-prime
rs112547817 -- 130,210,063(+) TGTCC(A/T)ATGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSMEM1 Gene

Variant ID Type Subtype PubMed ID
esv3615018 CNV loss 21293372
nsv508481 CNV deletion 20534489
nsv5950 CNV insertion 18451855

Variation tolerance for SSMEM1 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSMEM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSMEM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSMEM1 Gene

Disorders for SSMEM1 Gene

Relevant External Links for SSMEM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSMEM1

No disorders were found for SSMEM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSMEM1 Gene

Publications for SSMEM1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 64

Products for SSMEM1 Gene

Sources for SSMEM1 Gene

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