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SSH3 Gene

protein-coding   GIFtS: 53
GCID: GC11P067071

Slingshot Protein Phosphatase 3

(Previous name: slingshot homolog 3 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Slingshot Protein Phosphatase 31 2     Protein Phosphatase Slingshot Homolog 32
SSH-3L2 3     Slingshot 32
SSH3L2 3     Slingshot Homolog 32
hSSH-3L2 3     EC 3.1.3.163
SSH-Like Protein 32 3     EC 3.1.3.483
Slingshot Homolog 3 (Drosophila)1     

External Ids:    HGNC: 305811   Entrez Gene: 549612   Ensembl: ENSG000001728307   OMIM: 6067805   UniProtKB: Q8TE773   

Export aliases for SSH3 gene to outside databases

Previous GC identifers: GC11P066847 GC11P066827 GC11P063400


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSH3 Gene:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators
of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM
601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo
(Niwa et al., 2002 (PubMed 11832213)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SSH3 Gene:
SSH3 (slingshot protein phosphatase 3) is a protein-coding gene. GO annotations related to this gene include actin binding and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: SSH3_HUMAN, Q8TE77
Function: Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can
dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin
filaments and stimulates their disassembly (By similarity)

Gene Wiki entry for SSH3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSH3 gene promoter:
         SRF   NF-1   SRF (504 AA)   Nkx2-5   Nkx5-1   YY1   E47   Arnt   c-Ets-1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSH3 promoter sequence
   Search Chromatin IP Primers for SSH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

SSH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSH3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067071:  view genomic region     (about GC identifiers)

Start:
67,070,919 bp from pter      End:
67,080,078 bp from pter
Size:
9,160 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SSH3_HUMAN, Q8TE77 (See protein sequence)
Recommended Name: Protein phosphatase Slingshot homolog 3  
Size: 659 amino acids; 72996 Da
Subunit: Does not bind to, or colocalize with, filamentous actin (By similarity)
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Secondary accessions: Q6PK42 Q76I75 Q8N9L8 Q8WYL0 Q9NV45 Q9NWZ7
Alternative splicing: 5 isoforms:  Q8TE77-1   Q8TE77-2   Q8TE77-3   Q8TE77-4   Q8TE77-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSH3: NX_Q8TE77

Explore proteomics data for SSH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SSH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060327.3  
    ENSEMBL proteins: 
     ENSP00000312081   ENSP00000431788   ENSP00000310055   ENSP00000432974   ENSP00000365948  
     ENSP00000433902  

    SSH3 Human Recombinant Protein Products:

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    Novus Biologicals SSH3 Proteins
    Novus Biologicals SSH3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSH3

     
    Search eBioscience for Proteins for SSH3 

     
    antibodies-online proteins for SSH3 (6 products) 

     
    antibodies-online peptides for SSH3

    SSH3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SSH3
    antibodies-online antibodies for SSH3 (41 products) 

    SSH3 Assay Products:

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    Cloud-Clone Corp. ELISAs for SSH3
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    antibodies-online kits for SSH3 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPS: Protein tyrosine phosphatases / Class I Cys-based PTPs : Slingshots

    Selected InterPro protein domains (see all 7):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR014876 DEK_C
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q8TE77

    ProtoNet protein and cluster: Q8TE77

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: SSH3_HUMAN, Q8TE77
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with SSH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSH3_HUMAN, Q8TE77
    Function: Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can
    dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin
    filaments and stimulates their disassembly (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IBA--
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
    GO:0016791phosphatase activity ----
         
    Find genes that share ontologies with SSH3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SSH3:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ssh3):
     integument  normal  renal/urinary system  reproductive system  vision/eye 

    Find genes that share phenotypes with SSH3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSH3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSH3

    miRNA
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    miRTarBase miRNAs that target SSH3:
    hsa-mir-346 (MIRT004229)

    Block miRNA regulation of human, mouse, rat SSH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSH3 (see all 17):
    hsa-miR-485-5p hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-20b* hsa-miR-548a-3p hsa-miR-548x hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSSH3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SSH3
    Predesigned siRNA for gene silencing in human, mouse, rat SSH3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SSH3 (NM_017857)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSH3

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSH3_HUMAN, Q8TE77: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with SSH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSH3 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57


    Find genes that share SuperPaths with SSH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SSH3
        Regulation of Actin Cytoskeleton


    1 Kegg Pathway  (Kegg details for SSH3):
        Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSH3
    Interactions:

        Search GeneGlobe Interaction Network for SSH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SSH3 (Q8TE773 ENSP000003120814) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIMK1P536673, ENSP000003367404I2D: score=2 STRING: ENSP00000336740
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    CFL1P235283, ENSP000003096294I2D: score=1 STRING: ENSP00000309629
    YWHAZP631043I2D: score=1 
    CFL2ENSP000002981594STRING: ENSP00000298159
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IBA--
    GO:0008064regulation of actin polymerization or depolymerization IBA--
    GO:0010591regulation of lamellipodium assembly IBA--
    GO:0016311dephosphorylation ----
    GO:0050770regulation of axonogenesis IBA--

    Find genes that share ontologies with SSH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSH3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSH3 gene (2 alternative transcripts): 
    NM_018276.2  NM_017857.3  

    Unigene Cluster for SSH3:

    Slingshot protein phosphatase 3
    Hs.29173  [show with all ESTs]
    Unigene Representative Sequence: NM_017857
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308127(uc001okj.3 uc001okk.3) ENST00000532881(uc001okl.3)
    ENST00000308298 ENST00000532600 ENST00000376757 ENST00000534112 ENST00000532181
    ENST00000529224 ENST00000527821 ENST00000531495 ENST00000525913
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SSH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSH3 (see all 17):
    hsa-miR-485-5p hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-20b* hsa-miR-548a-3p hsa-miR-548x hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSSH3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SSH3
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    OriGene ORF clones in mouse, rat for SSH3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSH3 (NM_017857)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSH3
    Primer
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    OriGene qPCR primer pairs and template standards for SSH3
    OriGene qSTAR qPCR primer pairs in human, mouse for SSH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSH3
      QuantiTect SYBR Green Assays in human, mouse, rat SSH3
      QuantiFast Probe-based Assays in human, mouse, rat SSH3

    Additional mRNA sequence: 

    AB099291.1 AF085851.1 AK074432.1 AK124234.1 BC004176.2 BC004210.2 BC007709.1 

    12 DOTS entries:

    DT.311147  DT.100766111  DT.92430549  DT.101982180  DT.97842003  DT.75102919  DT.95175086  DT.120728683 
    DT.100026318  DT.100766113  DT.95175084  DT.120728686 

    Selected AceView cDNA sequences (see all 160):

    BM560192 AI139457 BF593164 BF477799 BC004210 BG831015 AA809940 BE672023 
    BM910493 BE348287 BE280203 BG750408 AL044785 AI763368 AB099291 AI373080 
    CD723716 BQ712114 BQ014446 BU537952 BX118751 NM_017857 BM471207 BQ188063 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSH3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                          -                             -                                                           -                                       
    SP2:                          -                             -                                                           -                 -                     
    SP3:                                                                                                                    -                                       
    SP4:                          -                             -                                         -     -     -     -     -     -     -     -               
    SP5:                                                        -                       -     -                                                                     

    ExUns: 16b ^ 17a · 17b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SSH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCCTGTC
    SSH3 Expression
    About this image


    SSH3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Spleen (Hematopoietic System)
    SSH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29173
        Custom PCR Arrays for SSH3
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SSH3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SSH3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssh31 , 5 slingshot homolog 3 (Drosophila)1, 5 82.41(n)1
    81.79(a)1
      19 (3.96 cM)5
    2458571  NM_198113.21  NP_932781.11 
     42616685 
    lizard
    (Anolis carolinensis)
    Reptilia SSH36
    slingshot protein phosphatase 3
    54(a)
    1 ↔ 1
    1(92824512-92856785)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004882631 protein phosphatase Slingshot homolog 56.76(n)
    55.22(a)
      100488263  XM_002938500.2  XP_002938546.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018866941 protein phosphatase Slingshot homolog 3-like 59.67(n)
    54.91(a)
      101886694  XM_005157325.1  XP_005157382.1 


    ENSEMBL Gene Tree for SSH3 (if available)
    TreeFam Gene Tree for SSH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSH3 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  DUSP162  DUSP92  DUSP22  
    DUSP82  DUSP12  DUSP72  SSH12  
    5 SIMAP similar genes for SSH3 using alignment to 6 protein entries:     SSH3_HUMAN (see all proteins):
    SSH1    DUSP19    SSH2    DUSP3    DUSP22

    Find genes that share paralogs with SSH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSH3 (see all 290)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425075951,2
    --67070484(+) CCCTCA/GTGGGC 1 -- us2k10--------
    rs1156618441,2
    C,F--67070525(+) TTTCCC/TCGGAA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1140188961,2
    C,F--67070633(+) CCTGAT/ACCTCT 1 -- us2k12Minor allele frequency- A:0.04WA EA 238
    rs1459714191,2
    C--67070679(+) CCTCCC/TTAGGA 1 -- us2k10--------
    rs42555461,2
    C,F,A,H--67070766(+) GCTTCT/CTGGGA 1 -- us2k1 tfbs323Minor allele frequency- C:0.35NS EA NA WA 2484
    rs1867137571,2
    C--67071345(+) AGCCCC/TGCGCG 1 -- int10--------
    rs42448221,2
    C,F,A,H--67071584(+) CTCTCG/CGCAGG 1 -- int110Minor allele frequency- C:0.06NS NA WA CSA EA EU 607
    rs1925227831,2
    C--67071633(+) TGAGCA/GCCACC 1 -- int10--------
    rs729307781,2
    C,F--67071990(+) CCCCTC/TTCCCC 1 -- int11Minor allele frequency- T:0.07NA 120
    rs1855875071,2
    --67072100(+) CAGGCC/TTCCAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SSH3 (67070919 - 67080078 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SSH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897800CNV Loss21882294
    nsv897796CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv897802CNV Loss21882294
    nsv468603CNV Loss19166990
    dgv1192n71CNV Loss21882294
    nsv897803CNV Loss21882294
    nsv897801CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSH3
    DNA2.0 Custom Variant and Variant Library Synthesis for SSH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606780    OMIM disorders: --


    Find genes that share disorders with SSH3           About GenesLikeMe


    Export disorders for SSH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSH3 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with SSH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (Cell 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. (PubMed id 14531860)1, 2 Ohta Y.... Mizuno K. (Genes Cells 2003)
    5. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. (PubMed id 18442045)1, 9 Kousaka K....Uemura T. (Genesis 2008)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. (PubMed id 17848544)1 Kligys K....Jones J.C. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54961 HGNC: 30581 AceView: SSH3 Ensembl:ENSG00000172830 euGenes: HUgn54961
    ECgene: SSH3 Kegg: 54961 H-InvDB: SSH3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SSH3 gene:
    Search GeneIP for patents involving SSH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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