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Aliases for SSH3 Gene

Aliases for SSH3 Gene

  • Slingshot Protein Phosphatase 3 2 3 5
  • SSH-Like Protein 3 3 4
  • HSSH-3L 3 4
  • SSH-3L 3 4
  • SSH3L 3 4
  • Slingshot Homolog 3 (Drosophila) 2
  • Slingshot Homolog 3 3
  • Slingshot 3 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4

External Ids for SSH3 Gene

Previous GeneCards Identifiers for SSH3 Gene

  • GC11P066847
  • GC11P066827
  • GC11P067071
  • GC11P063400

Summaries for SSH3 Gene

Entrez Gene Summary for SSH3 Gene

  • The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SSH3 Gene

SSH3 (Slingshot Protein Phosphatase 3) is a Protein Coding gene. Among its related pathways are Axon guidance and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for SSH3 Gene

  • Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).

Gene Wiki entry for SSH3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH3 Gene

Genomics for SSH3 Gene

Regulatory Elements for SSH3 Gene

Enhancers for SSH3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSH3 on UCSC Golden Path with GeneCards custom track

Promoters for SSH3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSH3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSH3 Gene

Chromosome:
11
Start:
67,303,448 bp from pter
End:
67,312,607 bp from pter
Size:
9,160 bases
Orientation:
Plus strand

Genomic View for SSH3 Gene

Genes around SSH3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH3 Gene

Proteins for SSH3 Gene

  • Protein details for SSH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TE77-SSH3_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 3
    Protein Accession:
    Q8TE77
    Secondary Accessions:
    • Q6PK42
    • Q76I75
    • Q8N9L8
    • Q8WYL0
    • Q9NV45
    • Q9NWZ7

    Protein attributes for SSH3 Gene

    Size:
    659 amino acids
    Molecular mass:
    72996 Da
    Quaternary structure:
    • Does not bind to, or colocalize with, filamentous actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date.

    Alternative splice isoforms for SSH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH3 Gene

Proteomics data for SSH3 Gene at MOPED

Post-translational modifications for SSH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SSH3 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SSH3 (SSH3)

No data available for DME Specific Peptides for SSH3 Gene

Domains & Families for SSH3 Gene

Gene Families for SSH3 Gene

Suggested Antigen Peptide Sequences for SSH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TE77

UniProtKB/Swiss-Prot:

SSH3_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH3: view

Function for SSH3 Gene

Molecular function for SSH3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity).

Enzyme Numbers (IUBMB) for SSH3 Gene

Gene Ontology (GO) - Molecular Function for SSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003779 actin binding IBA --
genes like me logo Genes that share ontologies with SSH3: view
genes like me logo Genes that share phenotypes with SSH3: view

Animal Models for SSH3 Gene

MGI Knock Outs for SSH3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SSH3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSH3 Gene

Localization for SSH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH3 Gene

Cytoplasm, cytoskeleton. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSH3 Gene COMPARTMENTS Subcellular localization image for SSH3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for SSH3 Gene

Pathways & Interactions for SSH3 Gene

genes like me logo Genes that share pathways with SSH3: view

Pathways by source for SSH3 Gene

1 Cell Signaling Technology pathway for SSH3 Gene
1 BioSystems pathway for SSH3 Gene
2 KEGG pathways for SSH3 Gene

Gene Ontology (GO) - Biological Process for SSH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0050770 regulation of axonogenesis IBA --
genes like me logo Genes that share ontologies with SSH3: view

No data available for SIGNOR curated interactions for SSH3 Gene

Drugs & Compounds for SSH3 Gene

(2) Additional Compounds for SSH3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with SSH3: view

Transcripts for SSH3 Gene

Unigene Clusters for SSH3 Gene

Slingshot protein phosphatase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSH3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: -
SP9: - - -
SP10:
SP11:

ExUns: 16b ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for SSH3 Gene

GeneLoc Exon Structure for
SSH3
ECgene alternative splicing isoforms for
SSH3

Expression for SSH3 Gene

mRNA expression in normal human tissues for SSH3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSH3 Gene

This gene is overexpressed in Nasal epithelium (17.1), Esophagus (7.3), and Prostate (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSH3 Gene



SOURCE GeneReport for Unigene cluster for SSH3 Gene Hs.29173

genes like me logo Genes that share expression patterns with SSH3: view

Protein tissue co-expression partners for SSH3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSH3 Gene

Orthologs for SSH3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSH3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSH3 35
  • 85.47 (n)
  • 83.15 (a)
SSH3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSH3 35
  • 86.24 (n)
  • 85.16 (a)
SSH3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssh3 35
  • 82.41 (n)
  • 81.79 (a)
Ssh3 16
Ssh3 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSH3 35
  • 99.14 (n)
  • 98.94 (a)
SSH3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssh3 35
  • 82.11 (n)
  • 82.52 (a)
oppossum
(Monodelphis domestica)
Mammalia SSH3 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSH3 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSH3 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488263 35
  • 56.76 (n)
  • 55.22 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101886694 35
  • 59.67 (n)
  • 54.91 (a)
CR847496.2 36
  • 42 (a)
OneToMany
SSH3 (2 of 2) 36
  • 27 (a)
OneToMany
Species with no ortholog for SSH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH3 Gene

ENSEMBL:
Gene Tree for SSH3 (if available)
TreeFam:
Gene Tree for SSH3 (if available)

Paralogs for SSH3 Gene

Paralogs for SSH3 Gene

(5) SIMAP similar genes for SSH3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SSH3: view

Variants for SSH3 Gene

Sequence variations from dbSNP and Humsavar for SSH3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7114712 - 67,307,662(+) CTCCG(A/T)ACAGA nc-transcript-variant, reference, missense
rs1573536 - 67,311,706(-) ACTGG(C/T)GGGAC downstream-variant-500B, reference, missense
rs1540136 -- 67,313,062(-) AGGCC(C/T)TTTGC downstream-variant-500B
rs11604985 -- 67,307,553(+) GGGCC(A/G)CACTC nc-transcript-variant, reference, missense
rs11608094 -- 67,306,061(+) GAGGC(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSH3 Gene

Variant ID Type Subtype PubMed ID
nsv897796 CNV Loss 21882294
nsv897797 CNV Loss 21882294
dgv1192n71 CNV Loss 21882294
nsv897800 CNV Loss 21882294
nsv468603 CNV Loss 19166990
nsv897801 CNV Loss 21882294
nsv897802 CNV Loss 21882294
nsv897803 CNV Loss 21882294

Variation tolerance for SSH3 Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SSH3 Gene

Disorders for SSH3 Gene

Relevant External Links for SSH3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSH3

No disorders were found for SSH3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSH3 Gene

Publications for SSH3 Gene

  1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PMID: 11832213) Niwa R. … Uemura T. (Cell 2002) 2 3 4 67
  2. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. (PMID: 18442045) Kousaka K. … Uemura T. (Genesis 2008) 3 23
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for SSH3 Gene

Sources for SSH3 Gene

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