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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSH3 Gene

protein-coding   GIFtS: 53
GCID: GC11P067071

Slingshot Protein Phosphatase 3

(Previous name: slingshot homolog 3 (Drosophila))
  Search for SSH3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Slingshot Protein Phosphatase 31 2     Protein Phosphatase Slingshot Homolog 32
SSH-3L2 3     Slingshot 32
SSH3L2 3     Slingshot Homolog 32
hSSH-3L2 3     EC 3.1.3.163
SSH-Like Protein 32 3     EC 3.1.3.483
Slingshot Homolog 3 (Drosophila)1     

External Ids:    HGNC: 305811   Entrez Gene: 549612   Ensembl: ENSG000001728307   OMIM: 6067805   UniProtKB: Q8TE773   

Export aliases for SSH3 gene to outside databases

Previous GC identifers: GC11P066847 GC11P066827 GC11P063400


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSH3 Gene:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators
of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM
601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo
(Niwa et al., 2002 (PubMed 11832213)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SSH3 Gene: 
SSH3 (slingshot protein phosphatase 3) is a protein-coding gene. Among its related super-pathways are Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: SSH3_HUMAN, Q8TE77
Function: Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can
dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin
filaments and stimulates their disassembly (By similarity)

Gene Wiki entry for SSH3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSH3 gene promoter:
         SRF   NF-1   SRF (504 AA)   Nkx2-5   Nkx5-1   YY1   E47   Arnt   c-Ets-1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

SSH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSH3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067071:  view genomic region     (about GC identifiers)

Start:
67,070,919 bp from pter      End:
67,080,078 bp from pter
Size:
9,160 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSH3_HUMAN, Q8TE77 (See protein sequence)
Recommended Name: Protein phosphatase Slingshot homolog 3  
Size: 659 amino acids; 72996 Da
Subunit: Does not bind to, or colocalize with, filamentous actin (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity)
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Secondary accessions: Q6PK42 Q76I75 Q8N9L8 Q8WYL0 Q9NV45 Q9NWZ7
Alternative splicing: 5 isoforms:  Q8TE77-1   Q8TE77-2   Q8TE77-3   Q8TE77-4   Q8TE77-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSH3: NX_Q8TE77

Explore proteomics data for SSH3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TE77

  • SSH3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSH3 Protein Expression
    REFSEQ proteins: NP_060327.3  
    ENSEMBL proteins: 
     ENSP00000312081   ENSP00000431788   ENSP00000310055   ENSP00000432974   ENSP00000365948  
     ENSP00000433902  

    Human Recombinant Protein Products for SSH3: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSH3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005856cytoskeleton IEA--

    SSH3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPS: Protein tyrosine phosphatases / Class I Cys-based PTPs : Slingshots

    5/7 InterPro protein domains (see all 7):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR014876 DEK_C
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q8TE77

    ProtoNet protein and cluster: Q8TE77

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: SSH3_HUMAN, Q8TE77
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    SSH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSH3_HUMAN, Q8TE77
    Function: Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can
    dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin
    filaments and stimulates their disassembly (By similarity)
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IBA--
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
    GO:0016791phosphatase activity ----
         
    SSH3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for SSH3:
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ssh3):
     integument  normal  renal/urinary system  reproductive system  vision/eye 

    SSH3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSH3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSH3 
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    miRNA
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    miRTarBase miRNAs that target SSH3:
    hsa-mir-346 (MIRT004229)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSH3
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SSH3 (see all 17):
    hsa-miR-485-5p hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-20b* hsa-miR-548a-3p hsa-miR-548x hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSSH3 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSH3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SSH3
        Regulation of Actin Cytoskeleton


    1         Kegg Pathway  (Kegg details for SSH3):
        Regulation of actin cytoskeleton


    SSH3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for SSH3 (Q8TE773 ENSP000003120814) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIMK1P536673, ENSP000003367404I2D: score=2 STRING: ENSP00000336740
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    CFL1P235283, ENSP000003096294I2D: score=1 STRING: ENSP00000309629
    YWHAZP631043I2D: score=1 
    CFL2ENSP000002981594STRING: ENSP00000298159
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IBA--
    GO:0008064regulation of actin polymerization or depolymerization IBA--
    GO:0010591regulation of lamellipodium assembly IBA--
    GO:0016311dephosphorylation ----
    GO:0050770regulation of axonogenesis IBA--

    SSH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSH3

    Search CenterWatch for drugs/clinical trials and news about SSH3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSH3 gene (2 alternative transcripts): 
    NM_018276.2  NM_017857.3  

    Unigene Cluster for SSH3:

    Slingshot protein phosphatase 3
    Hs.29173  [show with all ESTs]
    Unigene Representative Sequence: NM_017857
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308127(uc001okj.3 uc001okk.3) ENST00000532881(uc001okl.3)
    ENST00000308298 ENST00000532600 ENST00000376757 ENST00000534112 ENST00000532181
    ENST00000529224 ENST00000527821 ENST00000531495 ENST00000525913
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SSH3 (see all 17):
    hsa-miR-485-5p hsa-miR-146b-3p hsa-miR-520d-5p hsa-miR-20b* hsa-miR-548a-3p hsa-miR-548x hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidSSH3 3' UTR sequence
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    Additional mRNA sequence: 

    AB099291.1 AF085851.1 AK074432.1 AK124234.1 BC004176.2 BC004210.2 BC007709.1 

    12 DOTS entries:

    DT.311147  DT.100766111  DT.92430549  DT.101982180  DT.97842003  DT.75102919  DT.95175086  DT.120728683 
    DT.100026318  DT.100766113  DT.95175084  DT.120728686 

    24/160 AceView cDNA sequences (see all 160):

    BX118751 AB099291 AK074432 AA293163 BU190685 AB072360 AK000522 BE898514 
    AF085851 BF477799 AK124234 AI868920 AI540828 BG326709 AI763368 AA384757 
    BQ712114 CD723716 AL044785 BQ675874 AI874306 BX644944 BC004210 BQ014446 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SSH3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                          -                             -                                                           -                                       
    SP2:                          -                             -                                                           -                 -                     
    SP3:                                                                                                                    -                                       
    SP4:                          -                             -                                         -     -     -     -     -     -     -     -               
    SP5:                                                        -                       -     -                                                                     

    ExUns: 16b ^ 17a · 17b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for SSH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCCTGTC
    SSH3 Expression
    About this image


    See SSH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSH3

    SOURCE GeneReport for Unigene cluster: Hs.29173
        SABiosciences Custom PCR Arrays for SSH3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SSH3 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssh31 , 5 slingshot homolog 3 (Drosophila)1, 5 82.41(n)1
    81.79(a)1
      19 (3.96 cM)5
    2458571  NM_198113.21  NP_932781.11 
     42616685 
    lizard
    (Anolis carolinensis)
    Reptilia SSH36
    Uncharacterized protein
    53(a)
    1 ↔ 1
    1(92824512-92856785)
    zebrafish
    (Danio rerio)
    Actinopterygii CR847496.26
    SSH3 (1 of 2)6
    slingshot protein phosphatase 3
    40(a)
    24(a)
    1 ↔ many
    1 ↔ many
    14(36688809-36716682)
    Zv9_NA383(690-7646)


    ENSEMBL Gene Tree for SSH3 (if available)
    TreeFam Gene Tree for SSH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSH3 gene
    DUSP42  DUSP212  SSH22  DUSP102  DUSP62  DUSP142  DUSP282  DUSP82  
    DUSP72  DUSP52  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  DUSP12  
    5 SIMAP similar genes for SSH3 using alignment to 6 protein entries:     SSH3_HUMAN (see all proteins):
    SSH1    SSH2    DUSP19    DUSP3    DUSP22

    SSH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/290 SNPs in SSH3 are shown (see all 290)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425075951,2
    --67070484(+) CCCTCA/GTGGGC 1 -- us2k10--------
    rs1156618441,2
    C,F--67070525(+) TTTCCC/TCGGAA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1140188961,2
    C,F--67070633(+) CCTGAT/ACCTCT 1 -- us2k12Minor allele frequency- A:0.04WA EA 238
    rs1459714191,2
    C--67070679(+) CCTCCC/TTAGGA 1 -- us2k10--------
    rs42555461,2
    C,F,A,H--67070766(+) GCTTCT/CTGGGA 1 -- us2k1 tfbs323Minor allele frequency- C:0.35NS EA NA WA 2484
    rs1867137571,2
    C--67071345(+) AGCCCC/TGCGCG 1 -- int10--------
    rs42448221,2
    C,F,A,H--67071584(+) CTCTCG/CGCAGG 1 -- int110Minor allele frequency- C:0.06NS NA WA CSA EA EU 607
    rs1925227831,2
    C--67071633(+) TGAGCA/GCCACC 1 -- int10--------
    rs729307781,2
    C,F--67071990(+) CCCCTC/TTCCCC 1 -- int11Minor allele frequency- T:0.07NA 120
    rs1855875071,2
    --67072100(+) CAGGCC/TTCCAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SSH3 (67070919 - 67080078 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SSH3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897800CNV Loss21882294
    nsv897796CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv897802CNV Loss21882294
    nsv468603CNV Loss19166990
    dgv1192n71CNV Loss21882294
    nsv897803CNV Loss21882294
    nsv897801CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SSH3 for disorders           About MalaCards
    OMIM gene information: 606780    OMIM disorders: --


    SSH3 for disorders           About GeneDecksing


    Export disorders for SSH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSH3 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with SSH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. (PubMed id 14531860)1, 2 Ohta Y.... Mizuno K. (2003)
    5. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. (PubMed id 18442045)1, 9 Kousaka K....Uemura T. (2008)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. (PubMed id 17848544)1 Kligys K....Jones J.C. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54961 HGNC: 30581 AceView: SSH3 Ensembl:ENSG00000172830 euGenes: HUgn54961
    ECgene: SSH3 Kegg: 54961 H-InvDB: SSH3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSH3 gene:
    Search GeneIP for patents involving SSH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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