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SSH2 Gene

protein-coding   GIFtS: 54
GCID: GC17M027952

Slingshot Protein Phosphatase 2

(Previous name: slingshot homolog 2 (Drosophila))
  Search for SSH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Slingshot Protein Phosphatase 21 2     Protein Phosphatase Slingshot Homolog 22
SSH-2L2 3     EC 3.1.3.163
SSH-Like Protein 22 3     EC 3.1.3.483
KIAA17253 5     SSH2L3
Slingshot Homolog 2 (Drosophila)1     hSSH-2L3
SSH-22     

External Ids:    HGNC: 305801   Entrez Gene: 854642   Ensembl: ENSG000001412987   OMIM: 6067795   UniProtKB: Q76I763   

Export aliases for SSH2 gene to outside databases

Previous GC identifers: GC17M027612 GC17M029853 GC17M027804 GC17M028098 GC17M024977 GC17M024162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSH2 Gene:
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The
encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for SSH2 Gene:
SSH2 (slingshot protein phosphatase 2) is a protein-coding gene. GO annotations related to this gene include actin binding and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: SSH2_HUMAN, Q76I76
Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
inactivated by this protein

Gene Wiki entry for SSH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSH2 gene promoter:
         c-Fos   ER-alpha   AP-1   HNF-1A   Egr-2   PPAR-gamma1   HNF-1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSH2 promoter sequence
   Search Chromatin IP Primers for SSH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

SSH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027952:  view genomic region     (about GC identifiers)

Start:
27,952,956 bp from pter      End:
28,257,294 bp from pter
Size:
304,339 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SSH2_HUMAN, Q76I76 (See protein sequence)
Recommended Name: Protein phosphatase Slingshot homolog 2  
Size: 1423 amino acids; 158216 Da
Subunit: Interacts with filamentous actin
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Sequence caution: Sequence=AAH11636.2; Type=Erroneous initiation; Sequence=AAL92027.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SSH2:
2NT2 (3D)    
Secondary accessions: Q8TDB5 Q8WYL1 Q8WYL2 Q96F40 Q96H36 Q9C0D8
Alternative splicing: 4 isoforms:  Q76I76-1   Q76I76-2   Q76I76-3   Q76I76-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSH2: NX_Q76I76

Explore proteomics data for SSH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SSH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269058.1  NP_001269059.1  NP_001269060.1  NP_203747.2  

    ENSEMBL proteins: 
     ENSP00000269033   ENSP00000465703   ENSP00000444743   ENSP00000462605   ENSP00000467164  
     ENSP00000462583   ENSP00000466607   ENSP00000468037  

    SSH2 Human Recombinant Protein Products:

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    Novus Biologicals SSH2 Protein
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    Cloud-Clone Corp. Proteins for SSH2

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    SSH2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPS: Protein tyrosine phosphatases / Class I Cys-based PTPs : Slingshots

    Selected InterPro protein domains (see all 7):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR014876 DEK_C
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q76I76

    ProtoNet protein and cluster: Q76I76

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: SSH2_HUMAN, Q76I76
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    SSH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSH2_HUMAN, Q76I76
    Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
    binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
    disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
    inactivated by this protein
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IDA11832213
    GO:0004721phosphoprotein phosphatase activity IDA11832213
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
         
    SSH2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SSH2:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSH2
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    miRNA
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    miRTarBase miRNAs that target SSH2:
    hsa-mir-26b-5p (MIRT030263), hsa-mir-130b-5p (MIRT038300), hsa-mir-222-3p (MIRT046800)

    Block miRNA regulation of human, mouse, rat SSH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSH2 (see all 126):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-938 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSH2_HUMAN, Q76I76: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm IBA--
    GO:0005856cytoskeleton IEA--

    SSH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSH2 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SSH2
        Regulation of Actin Cytoskeleton


    1 Kegg Pathway  (Kegg details for SSH2):
        Regulation of actin cytoskeleton


    SSH2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including SSH2: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SSH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SSH2 (Q76I763 ENSP000002690334) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    CFL1P235283, ENSP000003096294I2D: score=1 STRING: ENSP00000309629
    PIWIL1Q96J943I2D: score=1 
    CFL2ENSP000002981594STRING: ENSP00000298159
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IMP11832213
    GO:0008064regulation of actin polymerization or depolymerization IBA--
    GO:0010591regulation of lamellipodium assembly IBA--
    GO:0016311dephosphorylation ----
    GO:0030036actin cytoskeleton organization IMP11832213

    SSH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSH2

    1 HMDB Compound for SSH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SSH2 gene (4 alternative transcripts): 
    NM_001282129.1  NM_001282130.1  NM_001282131.1  NM_033389.3  

    Unigene Cluster for SSH2:

    Slingshot protein phosphatase 2
    Hs.654754  [show with all ESTs]
    Unigene Representative Sequence: NM_033389
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269033(uc002heo.1 uc010wbh.1) ENST00000577991 ENST00000540801
    ENST00000394848(uc002hep.1) ENST00000579040(uc002her.3) ENST00000324677(uc002heq.3)
    ENST00000577483(uc010csc.1) ENST00000592397 ENST00000578411 ENST00000582084
    ENST00000590153 ENST00000579954
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SSH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSH2 (see all 126):
    hsa-miR-411* hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-938 hsa-miR-30d
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat SSH2

    Additional mRNA sequence: 

    AB051512.1 AB072358.1 AB072359.1 AB099290.1 AF484838.1 AK091432.1 AK094204.1 AK094429.1 
    AK296413.1 AK308887.1 BC008941.2 BC011636.2 BC068223.1 

    13 DOTS entries:

    DT.111434  DT.70100113  DT.92066226  DT.97820832  DT.75102746  DT.91817294  DT.91994429  DT.100892077 
    DT.120695921  DT.120726517  DT.120992480  DT.120992485  DT.97808584 

    Selected AceView cDNA sequences (see all 123):

    BQ065897 AA724472 AA768117 CB144904 BQ054521 BM454505 AA918495 BG059090 
    BM679356 CD742842 AW593110 AB051512 AF484838 AB099290 BQ643070 NM_033389 
    AW589742 AK091432 BM128015 AI927115 AI822087 AI767059 BC008941 AW590880 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SSH2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
    SP1:                          -     -           -                                                                                                   
    SP2:        -                                                                                                                                       
    SP3:                          -                                                                                                                     
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for SSH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SSH2 Expression
    About this image


    SSH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    SSH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654754
        Pathway & Disease-focused RT2 Profiler PCR Array including SSH2: 
              Cytoskeleton Regulators in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SSH2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssh21 , 5 slingshot homolog 2 (Drosophila)1, 5 85.94(n)1
    83.59(a)1
      11 (46.36 cM)5
    2378601  NM_177710.41  NP_808378.21 
     772162875 
    chicken
    (Gallus gallus)
    Aves SSH21 slingshot homolog 2 (Drosophila) 66.72(n)
    68.31(a)
      417586  XM_415832.4  XP_415832.3 
    lizard
    (Anolis carolinensis)
    Reptilia SSH26
    slingshot protein phosphatase 2
    60(a)
    1 ↔ 1
    GL343462.1(411352-472825)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL892268.22   -- 82.68(n)    AL892268.2 
    zebrafish
    (Danio rerio)
    Actinopterygii AI877888.12   -- 77.61(n)   325085  AI877888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ssh6
    slingshot
    29(a)
    1 → many
    3R(20764725-20770678)


    ENSEMBL Gene Tree for SSH2 (if available)
    TreeFam Gene Tree for SSH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSH2 gene
    DUSP42  DUSP52  DUSP102  DUSP62  SSH32  DUSP162  DUSP92  DUSP22  
    DUSP82  DUSP12  DUSP72  SSH12  
    7 SIMAP similar genes for SSH2 using alignment to 8 protein entries:     SSH2_HUMAN (see all proteins):
    SSH1    DUSP19    SSH3    DUSP28    DUSP14    DUSP22
    DUSP3

    SSH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSH2 (see all 4717)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379144001,2
    --27952512(+) ATCCTC/TAGAAT 1 -- ds50010--------
    rs1423232551,2
    C--27952600(+) ATGATC/TCAGAA 1 -- ds50010--------
    rs1913017141,2
    --27952657(+) GGGGGC/TGGGGA 1 -- ds50010--------
    rs1838025741,2
    --27952759(+) TCTCAC/TGATGT 1 -- ds50010--------
    rs10462431,2
    C,H--27953042(-) GCTCCA/CCTGTT 1 -- ut31 ese37Minor allele frequency- C:0.01MN NS EA NA 604
    rs562956121,2
    C--27953145(+) CAAATA/GCCTCA 1 -- ut310--------
    rs1451710261,2
    C--27953192(+) ATAAAA/TCATGA 1 -- ut310--------
    rs10462311,2
    C--27953198(-) TTATGC/GTCATG 1 -- ut31 ese33Minor allele frequency- G:0.00MN NA 188
    rs1893813661,2
    --27953270(+) CATGTC/TAGAAC 1 -- ut310--------
    rs2005449891,2
    C--27953300(+) AGAAAA/GANNNN 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SSH2 (27952956 - 28202956 bp, first 250kb of SSH2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SSH2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715804CNV Deletion23290073
    esv2715800CNV Deletion23290073
    esv2666488CNV Deletion23128226
    esv2715798CNV Deletion23290073
    esv2715802CNV Deletion23290073
    dgv451e201CNV Deletion23290073
    esv2715803CNV Deletion23290073
    nsv507838CNV Insertion20534489
    nsv112489CNV Loss16902084
    nsv908039CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606779    OMIM disorders: --


    SSH2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SSH2
    Human Genome Epidemiology (HuGE) Navigator: SSH2 (1 document)

    Export disorders for SSH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSH2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with SSH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (Cell 2002)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. (PubMed id 20477815)1, 4 Song S.Y....Lee S.H. (APMIS 2010)
    4. Crystal structure of human slingshot phosphatase 2. (PubMed id 17427953)1, 2 Jung S.K.... Kim S.J. (Proteins 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of genes expressed during myocardial development. (PubMed id 14527359)1, 2 Chan S.Y.... Leung M.P. (Chin. Med. J. 2003)
    7. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. (PubMed id 14531860)1, 2 Ohta Y.... Mizuno K. (Genes Cells 2003)
    8. Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt-Hogg-DubAc tumour suppressor gene (FLCN). (PubMed id 23416984)1 Lu X....Maher E.R. (Oncogene 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85464 HGNC: 30580 AceView: SSH2 Ensembl:ENSG00000141298 euGenes: HUgn85464
    ECgene: SSH2 Kegg: 85464 H-InvDB: SSH2

    (According to HUGE)
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    HUGE: KIAA1725

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SSH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSH2 gene:
    Search GeneIP for patents involving SSH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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