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Aliases for SSH2 Gene

Aliases for SSH2 Gene

  • Slingshot Protein Phosphatase 2 2 3 5
  • SSH-Like Protein 2 3 4
  • SSH-2L 3 4
  • Protein Phosphatase Slingshot Homolog 2 3
  • Slingshot Homolog 2 (Drosophila) 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KIAA1725 4
  • HSSH-2L 4
  • SSH-2 3
  • SSH2L 4

External Ids for SSH2 Gene

Previous GeneCards Identifiers for SSH2 Gene

  • GC17M027612
  • GC17M029853
  • GC17M027804
  • GC17M028098
  • GC17M024977
  • GC17M027952
  • GC17M024162

Summaries for SSH2 Gene

Entrez Gene Summary for SSH2 Gene

  • This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SSH2 Gene

SSH2 (Slingshot Protein Phosphatase 2) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Axon guidance. GO annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for SSH2 Gene

  • Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Gene Wiki entry for SSH2 Gene

Additional gene information for SSH2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH2 Gene

Genomics for SSH2 Gene

Regulatory Elements for SSH2 Gene

Enhancers for SSH2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H029849 1 Ensembl ENCODE 11.3 +80.2 80183 1 JUN BATF EED FOS ATF7 CREM MAFK IKZF2 JUNB DPF2 CORO6 ENSG00000239129 EFCAB5 SSH2 RPL9P30 ENSG00000252657
GH17H029835 1 Ensembl ENCODE 11.1 +93.9 93889 2 PKNOX1 BACH1 CEBPG GATA3 ZNF316 NFE2 MAFK SOX6 MAFG CEBPB CORO6 ENSG00000239129 SSH2 EFCAB5 RPL9P30 ENSG00000252657
GH17H029824 0.8 ENCODE 11.4 +104.7 104700 2 ELF3 SOX13 FOXA2 MAX YY1 ZNF664 POLR2A HNF4G HOMEZ RFX1 ENSG00000252657 SSH2 EFCAB5 ENSG00000239129 RNU6-920P TP53I13 RPL9P30
GH17H029844 0.7 ENCODE 11.6 +85.6 85560 0 NFIB GFI1B ZBTB8A ZFHX2 NFIC PRDM6 ZSCAN5C SCRT2 ZNF24 PRDM1 ENSG00000239129 EFCAB5 SSH2 RNU6-920P RPL9P30 ENSG00000252657
GH17H030005 0.7 ENCODE 10.9 -75.6 -75600 0 JUN ZNF133 CEBPG FOSL1 GATA3 ZNF316 FOS MAFK SMARCE1 SMARCC1 SSH2 EFCAB5 ENSG00000239129 BLMH RNU6-1267P ENSG00000264435 PIR56776
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSH2 on UCSC Golden Path with GeneCards custom track

Promoters for SSH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092939 376 2601 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Location for SSH2 Gene

Chromosome:
17
Start:
29,625,938 bp from pter
End:
29,930,276 bp from pter
Size:
304,339 bases
Orientation:
Minus strand

Genomic View for SSH2 Gene

Genes around SSH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH2 Gene

Proteins for SSH2 Gene

  • Protein details for SSH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76I76-SSH2_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 2
    Protein Accession:
    Q76I76
    Secondary Accessions:
    • Q8TDB5
    • Q8WYL1
    • Q8WYL2
    • Q96F40
    • Q96H36
    • Q9C0D8

    Protein attributes for SSH2 Gene

    Size:
    1423 amino acids
    Molecular mass:
    158216 Da
    Quaternary structure:
    • Interacts with filamentous actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date.
    SequenceCaution:
    • Sequence=AAH11636.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL92027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SSH2 Gene

    Alternative splice isoforms for SSH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH2 Gene

Post-translational modifications for SSH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH2 Gene

Domains & Families for SSH2 Gene

Gene Families for SSH2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SSH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q76I76

UniProtKB/Swiss-Prot:

SSH2_HUMAN :
  • Belongs to the protein-tyrosine phosphatase family.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH2: view

Function for SSH2 Gene

Molecular function for SSH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Enzyme Numbers (IUBMB) for SSH2 Gene

Phenotypes From GWAS Catalog for SSH2 Gene

Gene Ontology (GO) - Molecular Function for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 11832213
GO:0004721 phosphoprotein phosphatase activity IDA,IEA 11832213
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SSH2: view
genes like me logo Genes that share phenotypes with SSH2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SSH2

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSH2 Gene

Localization for SSH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSH2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IBA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SSH2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SSH2 Gene

Pathways & Interactions for SSH2 Gene

genes like me logo Genes that share pathways with SSH2: view

Pathways by source for SSH2 Gene

1 BioSystems pathway for SSH2 Gene
2 KEGG pathways for SSH2 Gene

Gene Ontology (GO) - Biological Process for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IMP 11832213
GO:0008064 regulation of actin polymerization or depolymerization IBA --
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0016311 dephosphorylation IEA --
GO:0030036 actin cytoskeleton organization IMP 11832213
genes like me logo Genes that share ontologies with SSH2: view

No data available for SIGNOR curated interactions for SSH2 Gene

Drugs & Compounds for SSH2 Gene

(2) Drugs for SSH2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for SSH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with SSH2: view

Transcripts for SSH2 Gene

Unigene Clusters for SSH2 Gene

Slingshot protein phosphatase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSH2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for SSH2 Gene

GeneLoc Exon Structure for
SSH2
ECgene alternative splicing isoforms for
SSH2

Expression for SSH2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSH2 Gene

This gene is overexpressed in Whole Blood (x12.5) and Muscle - Skeletal (x7.8).

Protein differential expression in normal tissues from HIPED for SSH2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (35.1), Pancreatic juice (14.1), Blymphocyte (7.1), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSH2 Gene



Protein tissue co-expression partners for SSH2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSH2 Gene:

SSH2

SOURCE GeneReport for Unigene cluster for SSH2 Gene:

Hs.654754

Evidence on tissue expression from TISSUES for SSH2 Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with SSH2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSH2 Gene

Orthologs for SSH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSH2 34 33
  • 99.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SSH2 33 34
  • 88.48 (n)
cow
(Bos Taurus)
Mammalia SSH2 33 34
  • 86.57 (n)
mouse
(Mus musculus)
Mammalia Ssh2 33 16 34
  • 85.94 (n)
rat
(Rattus norvegicus)
Mammalia Ssh2 33
  • 84.73 (n)
oppossum
(Monodelphis domestica)
Mammalia SSH2 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSH2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSH2 33 34
  • 66.72 (n)
lizard
(Anolis carolinensis)
Reptilia SSH2 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssh2 33
  • 62.19 (n)
zebrafish
(Danio rerio)
Actinopterygii ssh2a 34
  • 48 (a)
OneToMany
ssh2b 34
  • 46 (a)
OneToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta ssh 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToOne
Species where no ortholog for SSH2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH2 Gene

ENSEMBL:
Gene Tree for SSH2 (if available)
TreeFam:
Gene Tree for SSH2 (if available)

Paralogs for SSH2 Gene

Paralogs for SSH2 Gene

genes like me logo Genes that share paralogs with SSH2: view

Variants for SSH2 Gene

Sequence variations from dbSNP and Humsavar for SSH2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000001681 -- 29,932,190(+) TTGCC(A/C)CCCAG intron-variant, upstream-variant-2KB
rs1000024923 -- 29,930,338(+) CGTGC(G/T)CCTCG intron-variant, upstream-variant-2KB
rs1000041584 -- 29,872,719(+) GGGCC(A/G)GGTGG intron-variant
rs1000085825 -- 29,821,880(+) CTCTC(C/G)TAGTC intron-variant
rs1000129330 -- 29,823,748(+) GTGAC(A/G)CGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSH2 Gene

Variant ID Type Subtype PubMed ID
dgv410e201 CNV deletion 23290073
esv2666488 CNV deletion 23128226
esv2715798 CNV deletion 23290073
esv2715800 CNV deletion 23290073
esv2715802 CNV deletion 23290073
esv2715803 CNV deletion 23290073
esv2715804 CNV deletion 23290073
esv3332072 CNV insertion 20981092
esv3554301 CNV deletion 23714750
esv3640329 CNV loss 21293372
esv9716 CNV gain 19470904
nsv1109064 CNV deletion 24896259
nsv1109065 CNV deletion 24896259
nsv1123121 CNV deletion 24896259
nsv112489 CNV deletion 16902084
nsv1152451 CNV deletion 26484159
nsv442415 CNV loss 18776908
nsv507838 OTHER sequence alteration 20534489
nsv514833 CNV loss 21397061
nsv833409 CNV gain 17160897
nsv833410 CNV loss 17160897
nsv953875 CNV duplication 24416366
nsv962302 CNV duplication 23825009
nsv978403 CNV duplication 23825009

Variation tolerance for SSH2 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSH2 Gene

Human Gene Mutation Database (HGMD)
SSH2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSH2 Gene

Disorders for SSH2 Gene

Relevant External Links for SSH2

Genetic Association Database (GAD)
SSH2
Human Genome Epidemiology (HuGE) Navigator
SSH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSH2

No disorders were found for SSH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSH2 Gene

Publications for SSH2 Gene

  1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PMID: 11832213) Niwa R … Uemura T (Cell 2002) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  3. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. (PMID: 20477815) Song SY … Lee SH (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010) 3 45 60
  4. Crystal structure of human slingshot phosphatase 2. (PMID: 17427953) Jung SK … Kim SJ (Proteins 2007) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for SSH2 Gene

Sources for SSH2 Gene

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