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Aliases for SSH2 Gene

Aliases for SSH2 Gene

  • Slingshot Protein Phosphatase 2 2 3
  • SSH-Like Protein 2 3 4
  • SSH-2L 3 4
  • Slingshot Homolog 2 (Drosophila) 2
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KIAA1725 4
  • HSSH-2L 4
  • SSH-2 3
  • SSH2L 4

External Ids for SSH2 Gene

Previous GeneCards Identifiers for SSH2 Gene

  • GC17M027612
  • GC17M029853
  • GC17M027804
  • GC17M028098
  • GC17M024977
  • GC17M027952
  • GC17M024162

Summaries for SSH2 Gene

Entrez Gene Summary for SSH2 Gene

  • This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SSH2 Gene

SSH2 (Slingshot Protein Phosphatase 2) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH1.

UniProtKB/Swiss-Prot for SSH2 Gene

  • Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Gene Wiki entry for SSH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH2 Gene

Genomics for SSH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSH2 Gene

Chromosome:
17
Start:
29,625,938 bp from pter
End:
29,930,276 bp from pter
Size:
304,339 bases
Orientation:
Minus strand

Genomic View for SSH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH2 Gene

Proteins for SSH2 Gene

  • Protein details for SSH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76I76-SSH2_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 2
    Protein Accession:
    Q76I76
    Secondary Accessions:
    • Q8TDB5
    • Q8WYL1
    • Q8WYL2
    • Q96F40
    • Q96H36
    • Q9C0D8

    Protein attributes for SSH2 Gene

    Size:
    1423 amino acids
    Molecular mass:
    158216 Da
    Quaternary structure:
    • Interacts with filamentous actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date
    SequenceCaution:
    • Sequence=AAH11636.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL92027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SSH2 Gene

    Alternative splice isoforms for SSH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH2 Gene

Proteomics data for SSH2 Gene at MOPED

Post-translational modifications for SSH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH2 Gene

Domains & Families for SSH2 Gene

Gene Families for SSH2 Gene

Suggested Antigen Peptide Sequences for SSH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q76I76

UniProtKB/Swiss-Prot:

SSH2_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH2: view

Function for SSH2 Gene

Molecular function for SSH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Enzyme Numbers (IUBMB) for SSH2 Gene

Gene Ontology (GO) - Molecular Function for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003779 actin binding IDA 11832213
GO:0004721 phosphoprotein phosphatase activity IDA 11832213
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0008138 protein tyrosine/serine/threonine phosphatase activity IBA --
genes like me logo Genes that share ontologies with SSH2: view
genes like me logo Genes that share phenotypes with SSH2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSH2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SSH2 Gene

Localization for SSH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSH2 Gene COMPARTMENTS Subcellular localization image for SSH2 gene
Compartment Confidence
cytoskeleton 5
extracellular 5

Gene Ontology (GO) - Cellular Components for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IBA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with SSH2: view

Pathways & Interactions for SSH2 Gene

genes like me logo Genes that share pathways with SSH2: view

Pathways by source for SSH2 Gene

1 BioSystems pathway for SSH2 Gene
1 KEGG pathway for SSH2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SSH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IMP 11832213
GO:0008064 regulation of actin polymerization or depolymerization IBA --
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0016311 dephosphorylation --
GO:0030036 actin cytoskeleton organization IMP 11832213
genes like me logo Genes that share ontologies with SSH2: view

No data available for SIGNOR curated interactions for SSH2 Gene

Drugs & Compounds for SSH2 Gene

(3) Additional Compounds for SSH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with SSH2: view

Transcripts for SSH2 Gene

Unigene Clusters for SSH2 Gene

Slingshot protein phosphatase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSH2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSH2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for SSH2 Gene

GeneLoc Exon Structure for
SSH2
ECgene alternative splicing isoforms for
SSH2

Expression for SSH2 Gene

mRNA expression in normal human tissues for SSH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SSH2 Gene

This gene is overexpressed in Whole Blood (x12.5) and Muscle - Skeletal (x7.8).

Protein differential expression in normal tissues from HIPED for SSH2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (35.1), Pancreatic juice (14.1), Blymphocyte (7.1), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SSH2 Gene



SOURCE GeneReport for Unigene cluster for SSH2 Gene Hs.654754

genes like me logo Genes that share expression patterns with SSH2: view

Protein tissue co-expression partners for SSH2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SSH2 Gene

Orthologs for SSH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSH2 35
  • 86.57 (n)
  • 85.11 (a)
SSH2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSH2 35
  • 88.48 (n)
  • 86.13 (a)
SSH2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssh2 35
  • 85.94 (n)
  • 83.59 (a)
Ssh2 16
Ssh2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSH2 35
  • 99.5 (n)
  • 99.13 (a)
SSH2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssh2 35
  • 84.73 (n)
  • 81.72 (a)
oppossum
(Monodelphis domestica)
Mammalia SSH2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSH2 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSH2 35
  • 66.72 (n)
  • 68.31 (a)
SSH2 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSH2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssh2 35
  • 62.19 (n)
  • 60.87 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ssh2a 36
  • 48 (a)
OneToMany
ssh2b 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ssh 36
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for SSH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH2 Gene

ENSEMBL:
Gene Tree for SSH2 (if available)
TreeFam:
Gene Tree for SSH2 (if available)

Paralogs for SSH2 Gene

Paralogs for SSH2 Gene

genes like me logo Genes that share paralogs with SSH2: view

Variants for SSH2 Gene

Sequence variations from dbSNP and Humsavar for SSH2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs808840 -- 29,637,863(-) gtgct(A/G)ggatt intron-variant
rs809513 -- 29,637,942(-) gagac(A/G)gggtt intron-variant
rs811291 -- 29,637,851(-) caggc(A/G)tgagc intron-variant
rs812727 -- 29,637,969(-) tccca(A/G)ctaat intron-variant
rs813282 -- 29,637,912(-) ggtct(C/T)gaact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSH2 Gene

Variant ID Type Subtype PubMed ID
nsv833409 CNV Gain 17160897
nsv833410 CNV Loss 17160897
nsv908039 CNV Loss 21882294
esv2666488 CNV Deletion 23128226
nsv514833 CNV Loss 21397061
nsv442415 CNV CNV 18776908
nsv507838 CNV Insertion 20534489
esv2715798 CNV Deletion 23290073
dgv451e201 CNV Deletion 23290073
esv2715800 CNV Deletion 23290073
nsv112489 CNV Loss 16902084
esv2715802 CNV Deletion 23290073
esv2715803 CNV Deletion 23290073
esv2715804 CNV Deletion 23290073

Variation tolerance for SSH2 Gene

Residual Variation Intolerance Score: 44.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSH2 Gene

HapMap Linkage Disequilibrium report
SSH2
Human Gene Mutation Database (HGMD)
SSH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSH2 Gene

Disorders for SSH2 Gene

Relevant External Links for SSH2

Genetic Association Database (GAD)
SSH2
Human Genome Epidemiology (HuGE) Navigator
SSH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSH2
genes like me logo Genes that share disorders with SSH2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSH2 Gene

Publications for SSH2 Gene

  1. LIM kinase and slingshot are critical for neurite extension. (PMID: 17360713) Endo M. … Mizuno K. (J. Biol. Chem. 2007) 23 67
  2. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PMID: 11832213) Niwa R. … Uemura T. (Cell 2002) 2 67
  3. Identification of gene clusters differentially expressed during the cellular injury responses (CIR) to cisplatin. (PMID: 11710836) Johnsson A. … Los G. (Br. J. Cancer 2001) 23 67
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  5. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. (PMID: 25288136) . … Chasman D.I. (Mol. Psychiatry 2015) 67

Products for SSH2 Gene

Sources for SSH2 Gene

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