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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSH2 Gene

protein-coding   GIFtS: 53
GCID: GC17M027952

Slingshot Protein Phosphatase 2

(Previous name: slingshot homolog 2 (Drosophila))
  Search for SSH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Slingshot Protein Phosphatase 21 2     Protein Phosphatase Slingshot Homolog 22
SSH-2L2 3     EC 3.1.3.163
SSH-Like Protein 22 3     EC 3.1.3.483
KIAA17253 5     SSH2L3
Slingshot Homolog 2 (Drosophila)1     hSSH-2L3
SSH-22     

External Ids:    HGNC: 305801   Entrez Gene: 854642   Ensembl: ENSG000001412987   OMIM: 6067795   UniProtKB: Q76I763   

Export aliases for SSH2 gene to outside databases

Previous GC identifers: GC17M027612 GC17M029853 GC17M027804 GC17M028098 GC17M024977 GC17M024162


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSH2 Gene:
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The
encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for SSH2 Gene: 
SSH2 (slingshot protein phosphatase 2) is a protein-coding gene. Among its related super-pathways are Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: SSH2_HUMAN, Q76I76
Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
inactivated by this protein

Gene Wiki entry for SSH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSH2 gene promoter:
         c-Fos   ER-alpha   AP-1   HNF-1A   Egr-2   PPAR-gamma1   HNF-1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

SSH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSH2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M027952:  view genomic region     (about GC identifiers)

Start:
27,952,956 bp from pter      End:
28,257,294 bp from pter
Size:
304,339 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSH2_HUMAN, Q76I76 (See protein sequence)
Recommended Name: Protein phosphatase Slingshot homolog 2  
Size: 1423 amino acids; 158216 Da
Subunit: Interacts with filamentous actin
Subcellular location: Cytoplasm, cytoskeleton
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Sequence caution: Sequence=AAH11636.2; Type=Erroneous initiation; Sequence=AAL92027.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for SSH2:
2NT2 (3D)    
Secondary accessions: Q8TDB5 Q8WYL1 Q8WYL2 Q96F40 Q96H36 Q9C0D8
Alternative splicing: 4 isoforms:  Q76I76-1   Q76I76-2   Q76I76-3   Q76I76-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSH2: NX_Q76I76

Explore proteomics data for SSH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q76I76

  • SSH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSH2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269058.1  NP_001269059.1  NP_001269060.1  NP_203747.2  

    ENSEMBL proteins: 
     ENSP00000269033   ENSP00000465703   ENSP00000444743   ENSP00000462605   ENSP00000467164  
     ENSP00000462583   ENSP00000466607   ENSP00000468037  

    Human Recombinant Protein Products for SSH2: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for SSH2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005856cytoskeleton IEA--

    SSH2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPS: Protein tyrosine phosphatases / Class I Cys-based PTPs : Slingshots

    5/7 InterPro protein domains (see all 7):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR014876 DEK_C
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q76I76

    ProtoNet protein and cluster: Q76I76

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: SSH2_HUMAN, Q76I76
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    SSH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSH2_HUMAN, Q76I76
    Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
    binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
    disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
    inactivated by this protein
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IDA11832213
    GO:0004721phosphoprotein phosphatase activity IDA11832213
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0008138protein tyrosine/serine/threonine phosphatase activity IBA--
         
    SSH2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SSH2:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSH2 
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    hsa-miR-411* hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-938 hsa-miR-30d
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSH2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SSH2
        Regulation of Actin Cytoskeleton


    1         Kegg Pathway  (Kegg details for SSH2):
        Regulation of actin cytoskeleton


    SSH2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSH2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SSH2 (Q76I763 ENSP000002690334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=2 STRING: ENSP00000349960
    CFL1P235283, ENSP000003096294I2D: score=1 STRING: ENSP00000309629
    PIWIL1Q96J943I2D: score=1 
    CFL2ENSP000002981594STRING: ENSP00000298159
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006470protein dephosphorylation IMP11832213
    GO:0008064regulation of actin polymerization or depolymerization IBA--
    GO:0010591regulation of lamellipodium assembly IBA--
    GO:0016311dephosphorylation ----
    GO:0030036actin cytoskeleton organization IMP11832213

    SSH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSH2

    1 HMDB Compound for SSH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    Search CenterWatch for drugs/clinical trials and news about SSH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSH2 gene (4 alternative transcripts): 
    NM_001282129.1  NM_001282130.1  NM_001282131.1  NM_033389.3  

    Unigene Cluster for SSH2:

    Slingshot protein phosphatase 2
    Hs.654754  [show with all ESTs]
    Unigene Representative Sequence: NM_033389
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269033(uc002heo.1 uc010wbh.1) ENST00000577991 ENST00000540801
    ENST00000394848(uc002hep.1) ENST00000579040(uc002her.3) ENST00000324677(uc002heq.3)
    ENST00000577483(uc010csc.1) ENST00000592397 ENST00000578411 ENST00000582084
    ENST00000590153 ENST00000579954
    miRNA
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    hsa-miR-411* hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-938 hsa-miR-30d
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    Additional mRNA sequence: 

    AB051512.1 AB072358.1 AB072359.1 AB099290.1 AF484838.1 AK091432.1 AK094204.1 AK094429.1 
    AK296413.1 AK308887.1 BC008941.2 BC011636.2 BC068223.1 

    13 DOTS entries:

    DT.111434  DT.70100113  DT.92066226  DT.97820832  DT.75102746  DT.91817294  DT.91994429  DT.100892077 
    DT.120695921  DT.120726517  DT.120992480  DT.120992485  DT.97808584 

    24/123 AceView cDNA sequences (see all 123):

    BQ054521 BM454505 AA918495 BG059090 BM679356 CD742842 AW593110 AB051512 
    AF484838 AB099290 BQ643070 BQ065897 NM_033389 AW589742 AK091432 BM128015 
    AI927115 AI822087 AI767059 BC008941 AW590880 AX746979 AI884822 BC011636 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SSH2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
    SP1:                          -     -           -                                                                                                   
    SP2:        -                                                                                                                                       
    SP3:                          -                                                                                                                     
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for SSH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SSH2 Expression
    About this image


    See SSH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSH2

    SOURCE GeneReport for Unigene cluster: Hs.654754
        SABiosciences Expression via Pathway-Focused PCR Array including SSH2: 
              Cytoskeleton Regulators in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SSH2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssh21 , 5 slingshot homolog 2 (Drosophila)1, 5 85.92(n)1
    83.59(a)1
      11 (46.36 cM)5
    2378601  NM_177710.41  NP_808378.21 
     772162875 
    chicken
    (Gallus gallus)
    Aves SSH21 slingshot homolog 2 (Drosophila) 66.9(n)
    68.65(a)
      417586  XM_415832.3  XP_415832.3 
    lizard
    (Anolis carolinensis)
    Reptilia SSH26
    Uncharacterized protein
    58(a)
    1 ↔ 1
    GL343462.1(411352-472825)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL892268.22   -- 82.68(n)    AL892268.2 
    zebrafish
    (Danio rerio)
    Actinopterygii AI877888.12   -- 77.61(n)   325085  AI877888.1 


    ENSEMBL Gene Tree for SSH2 (if available)
    TreeFam Gene Tree for SSH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSH2 gene
    DUSP42  DUSP212  DUSP102  DUSP62  DUSP142  DUSP282  DUSP82  DUSP72  
    DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  SSH12  DUSP12  
    7 SIMAP similar genes for SSH2 using alignment to 9 protein entries:     SSH2_HUMAN (see all proteins):
    SSH1    SSH3    DUSP19    DUSP28    DUSP14    DUSP22
    DUSP3

    SSH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4717 SNPs in SSH2 are shown (see all 4717)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1379144001,2
    --27952512(+) ATCCTC/TAGAAT 1 -- ds50010--------
    rs1423232551,2
    C--27952600(+) ATGATC/TCAGAA 1 -- ds50010--------
    rs1913017141,2
    --27952657(+) GGGGGC/TGGGGA 1 -- ds50010--------
    rs1838025741,2
    --27952759(+) TCTCAC/TGATGT 1 -- ds50010--------
    rs10462431,2
    C,H--27953042(-) GCTCCA/CCTGTT 1 -- ut31 ese37Minor allele frequency- C:0.01MN NS EA NA 604
    rs562956121,2
    C--27953145(+) CAAATA/GCCTCA 1 -- ut310--------
    rs1451710261,2
    C--27953192(+) ATAAAA/TCATGA 1 -- ut310--------
    rs10462311,2
    C--27953198(-) TTATGC/GTCATG 1 -- ut31 ese33Minor allele frequency- G:0.00MN NA 188
    rs1893813661,2
    --27953270(+) CATGTC/TAGAAC 1 -- ut310--------
    rs2005449891,2
    C--27953300(+) AGAAAA/GANNNN 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SSH2 (27952956 - 28202956 bp, first 250kb of SSH2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for SSH2 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715804CNV Deletion23290073
    esv2715800CNV Deletion23290073
    esv2666488CNV Deletion23128226
    esv2715798CNV Deletion23290073
    esv2715802CNV Deletion23290073
    dgv451e201CNV Deletion23290073
    esv2715803CNV Deletion23290073
    nsv507838CNV Insertion20534489
    nsv112489CNV Loss16902084
    nsv908039CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SSH2 for disorders           About MalaCards
    OMIM gene information: 606779    OMIM disorders: --


    SSH2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SSH2
    Human Genome Epidemiology (HuGE) Navigator: SSH2 (1 document)

    Export disorders for SSH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSH2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SSH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (2002)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with mi crosatellite instability. (PubMed id 20477815)1, 4 Song S.Y....Lee S.H. (2010)
    4. Crystal structure of human slingshot phosphatase 2. (PubMed id 17427953)1, 2 Jung S.K.... Kim S.J. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of genes expressed during myocardial development. (PubMed id 14527359)1, 2 Chan S.Y.... Leung M.P. (2003)
    7. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. (PubMed id 14531860)1, 2 Ohta Y.... Mizuno K. (2003)
    8. Knockdown of Slingshot 2 (SSH2) serine phosphatase ind uces Caspase3 activation in human carcinoma cell lines with the loss of the Birt -Hogg-Dube tumour suppressor gene (FLCN). (PubMed id 23416984)1 Lu X....Maher E.R. (2013)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. Slingshot isoform-specific regulation of cofilin-media ted vascular smooth muscle cell migration and neointima formation. (PubMed id 21868701)1 Torres R.A....Weber D.S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 85464 HGNC: 30580 AceView: SSH2 Ensembl:ENSG00000141298 euGenes: HUgn85464
    ECgene: SSH2 Kegg: 85464 H-InvDB: SSH2

    (According to HUGE)
    About This Section
    HUGE: KIAA1725

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSH2 gene:
    Search GeneIP for patents involving SSH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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