SSH1 Gene
protein-coding GIFtS: 60
GCID: GC12M109180
|
|
slingshot homolog 1 (Drosophila)
| |
Aliases
for SSH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Slingshot Homolog 1 (Drosophila)1 2 | | Protein Phosphatase Slingshot Homolog 12 | | KIAA12981 3 5 | | EC 3.1.3.163 | | SSH1L2 3 | | EC 3.1.3.483 | | HSSH-1L1 | | SSH-1L3 | | SSH-Like Protein 12 3 | | |
Export aliases for SSH1 gene to outside databasesPrevious GC identifers: GC12M108286 GC12M109057 GC12M109111 GC12M107681 GC12M107683 GC12M107705 GC12M106241 |
Summaries
for SSH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SSH1:
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actinfilament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin,which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases suchas LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH familythus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcriptvariants encoding different isoforms have been described for this gene. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actinbinding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by thisprotein
Gene Wiki entry for SSH1
|
Genomic Views
for SSH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSH1 gene promoter:
AP-2gamma Egr-4 NF-AT NF-AT4 NF-AT2 AP-2beta NF-AT3 AP-2alpha AP-2alphaA NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSH1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSH1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.12SSH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M109180: view genomic region
(about GC identifiers)
Start:
|
109,176,466 bp from pter |
End:
|
109,251,366 bp from pter |
Size:
|
74,901 bases |
Orientation:
|
minus strand |
|
Proteins
for SSH1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5 (See
protein sequence)Recommended Name: Protein phosphatase Slingshot homolog 1 Size: 1049 amino acids; 115511 Da
Subunit: Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and alsoblocks recruitment to lamellipodia and stimulation by actin
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Alsorecruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics atsites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Sequence caution: Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6P6C0 Q8N9A7 Q8WYL3 Q8WYL4 Q9P2P8Alternative splicing: 5 isoforms: Q8WYL5-1 Q8WYL5-2 Q8WYL5-3 Q8WYL5-4 Q8WYL5-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SSH1: NX_Q8WYL5
Post-translational modifications:
Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreasedby stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated byPPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WYL5
SSH1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001154802.1 NP_001154803.1 NP_061857.3
ENSEMBL proteins: ENSP00000315713 ENSP00000447629 ENSP00000448824 ENSP00000326107 ENSP00000448586 ENSP00000446652 ENSP00000353374
Human Recombinant Protein Products for SSH1:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
SSH1 for ontologies About GeneDecksing
SSH1 Antibody Products:
Assay Products for SSH1: |
Protein
Domains /
Families
for SSH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSH1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8WYL5ProtoNet protein and cluster: Q8WYL5 1 Blocks protein family: IPB000340 Dual specificity protein phosphatase
UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5Similarity: Belongs to the protein-tyrosine phosphatase familySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Function
for SSH1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SSH1_HUMAN, Q8WYL5Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actinbinding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by thisproteinCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphate Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
SSH1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSH1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSH1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): SSH1 (NM_018984) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSH1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSH1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH1 |
|
Pathways & Interactions
for SSH1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Regulation of Actin Cytoskeleton | | | 2 | CXCR4-mediated signaling events | | | 3 | FGF signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for SSH1
1 
Kegg Pathway (Kegg details for SSH1):
SSH1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSH1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 17)
5/20 Interacting proteins for SSH1 (Q8WYL51, 2, 3 ENSP000003157134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| YWHAB | P319462, 3, ENSP000003001614 | MINT-8006699 MINT-8006692 MINT-8008870 I2D:
score=1 STRING: ENSP00000300161 | | CFL1 | P235282, 3, ENSP000003096294 | MINT-8185692 MINT-8185710 I2D:
score=4 STRING: ENSP00000309629 | | CORO1B | Q9BR761, 3, ENSP000003402114 | EBI-1222387,EBI-351152 I2D:
score=2 STRING: ENSP00000340211 | | YWHAQ | P273482, 3, ENSP000002380814 | MINT-8008916 I2D:
score=1 STRING: ENSP00000238081 | | YWHAZ | P631042, 3, ENSP000003095034 | MINT-8008923 I2D:
score=4 STRING: ENSP00000309503 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
SSH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SSH1
1 HMDB Compound for SSH1 About this table
Search CenterWatch for drugs/clinical trials and news about SSH1
|
Transcripts
for SSH1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SSH1 gene (3 alternative transcripts): NM_001161330.1 NM_001161331.1 NM_018984.3 Unigene Cluster for SSH1: Slingshot homolog 1 (Drosophila) Hs.199763 [show with all ESTs]Unigene Representative Sequence: NM_01898410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326495(uc001tnm.3) ENST00000546433 ENST00000551165(uc001tnn.4)
ENST00000326470(uc010sxg.2) ENST00000547862(uc001tno.1) ENST00000548522
ENST00000547381 ENST00000546697 ENST00000546812 ENST00000360239(uc001tnl.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSH1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSH1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): SSH1 (NM_018984) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SSH1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSH1 |
Additional cDNA sequence: AB037719.1 AB072355.1 AB072356.1 AB072357.1 AK025581.1 AK095421.1 BC005101.1 BC013792.1 BC020243.1 BC062341.1 12 DOTS entries: DT.455121 DT.100736574 DT.40192573 DT.97791344 DT.99936175 DT.100762767 DT.91685765 DT.121191769 DT.91882424 DT.95253954 DT.121191815 DT.97763549 24/231 AceView cDNA sequences (see all 231): AB072356 AI753519 AI917378 BM701229 CD679254 AI559706 AI952731 CR623842 BQ929507 BQ448529 BQ893338 AK025581 AI288068 BX643818 BU182778 AI651213 AI457799 AB037719 AL121363 BU742742 CA447966 BM674139 CB215553 BX508167
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SSH1
|
Expression
for SSH1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SSH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTTGTTTGG
About this image
See SSH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SSH1
SOURCE GeneReport for Unigene cluster: Hs.199763
SABiosciences Expression via Pathway-Focused PCR Arrays including SSH1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSH1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSH1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH1 |
Orthologs
for SSH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SSH1 gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SSH16 |
Uncharacterized protein |
52(a) |
1 ↔ 1 |
15(6706741-6728818) |
lizard
(Anolis carolinensis) |
Reptilia |
SSH16 |
-- |
55(a) |
1 ↔ 1 |
GL344393.1(692-12689) |
African clawed frog
(Xenopus laevis) |
Amphibia |
SSH2 |
slingshot-related protein |
75.32(n) |
|
AY233266.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ssh1b1 |
slingshot homolog 1b (Drosophila) |
59.16(n)
58.47(a) |
|
567479 XM_690775.3 XP_695867.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
ssh3 |
regulation of actin polymerization and/or
depolymerization more |
51(a) |
|
-- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PHS16 |
dual specificity protein phosphatase family protei... |
8(a) |
1 → many |
5(7998230-8002840) |
rice
(Oryza sativa) |
Liliopsida |
---- |
PHS1, putative, expressed |
8(a)8(a) |
many ↔ manymany ↔ many |
1(13793660-13798880) 1(11692783-11698999) |
ENSEMBL Gene Tree for SSH1 (if available)
TreeFam Gene Tree for SSH1 (if available) |
Paralogs
for SSH1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SSH1 gene
- DUSP42 DUSP212 SSH22 DUSP102 DUSP62 DUSP192 DUSP142 DUSP282
- DUSP82 DUSP72 DUSP52 SSH32 DUSP162 DUSP92 DUSP22 DUSP182
- DUSP12
7 SIMAP similar genes for SSH1 using alignment to 4 protein entries: SSH1_HUMAN (see all proteins):SSH2 SSH3 DUSP19 DUSP3 DUSP28 DUSP14
DUSP22
SSH1 for paralogs About GeneDecksing
|
Genomic Variants
for SSH1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SSH1 (109176466 - 109251366 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SSH1
1 CNV: 5312
4 Indels: 71575 76146 86560 76147
Human Gene Mutation Database (HGMD): SSH1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSH1 |
|
Disorders
/ Diseases
for SSH1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSH1 for disorders About GeneDecksing
OMIM gene information: 606778
OMIM disorders: --
5  diseases for SSH1: About MalaCardsporokeratosis keratosis colon carcinoma carcinoma
neuronitis
1 disease from the University of Copenhagen DISEASES database for SSH1:Keratosis Human Genome Epidemiology (HuGE) Navigator: SSH1 (1 document)
Export disorders for SSH1 gene to outside databases
|
Publications
for SSH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SSH1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with SSH1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (2002)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2, 9 Nagata-Ohashi K.... Mizuno K. (2004)
- Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2, 9 Wang Y.... Mizuno K. (2005)
- Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. (PubMed id 12807904)1, 2, 9 Kaji N.... Mizuno K. (2003)
- Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. (PubMed id 12684437)1, 2, 9 Endo M....Mizuno K. (2003)
- Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 9 Soosairajah J.... Bernard O. (2005)
- Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. (PubMed id 16230460)1, 2, 9 Nishita M.... Mizuno K. (2005)
- Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. (PubMed id 14645219)1, 2 Nishita M....Mizuno K. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for SSH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SSH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSH1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SSH1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SSH1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SSH1 gene:
Search GeneIP for patents involving SSH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SSH1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SSH1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SSH1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SSH1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SSH1 | | OriGene 3'-UTR Clone for SSH1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SSH1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SSH1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SSH1 | | OriGene Custom Protein Services for SSH1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSH1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSH1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSH1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSH1 |
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| | | | Search Tocris compounds for SSH1 |
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 | | | SSH1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for SSH1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSH1 |
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