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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSH1 Gene

protein-coding   GIFtS: 62
GCID: GC12M109180

Slingshot Protein Phosphatase 1

(Previous name: slingshot homolog 1 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Slingshot Protein Phosphatase 11 2     Protein Phosphatase Slingshot Homolog 12
SSH1L2 3     Slingshot Homolog 12
hSSH-1L2 3     EC 3.1.3.163
SSH-Like Protein 12 3     EC 3.1.3.483
KIAA12983 5     SSH-1L3
Slingshot Homolog 1 (Drosophila)1     

External Ids:    HGNC: 305791   Entrez Gene: 544342   Ensembl: ENSG000000841127   OMIM: 6067785   UniProtKB: Q8WYL53   

Export aliases for SSH1 gene to outside databases

Previous GC identifers: GC12M108286 GC12M109057 GC12M109111 GC12M107681 GC12M107683 GC12M107705 GC12M106241


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSH1 Gene:
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate
actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor
cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by
kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins.
The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively
spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq,
Aug 2011)

GeneCards Summary for SSH1 Gene: 
SSH1 (slingshot protein phosphatase 1) is a protein-coding gene. Diseases associated with SSH1 include porokeratosis, and keratosis, and among its related super-pathways are Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5
Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
inactivated by this protein

Gene Wiki entry for SSH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSH1 gene promoter:
         AP-2gamma   Egr-4   NF-AT   NF-AT4   NF-AT2   AP-2beta   NF-AT3   AP-2alpha   AP-2alphaA   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.12

SSH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSH1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109180:  view genomic region     (about GC identifiers)

Start:
109,176,466 bp from pter      End:
109,251,366 bp from pter
Size:
74,901 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5 (See protein sequence)
Recommended Name: Protein phosphatase Slingshot homolog 1  
Size: 1049 amino acids; 115511 Da
Subunit: Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the
14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity
and also blocks recruitment to lamellipodia and stimulation by actin
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also
recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin
dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Sequence caution: Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6P6C0 Q8N9A7 Q8WYL3 Q8WYL4 Q9P2P8
Alternative splicing: 5 isoforms:  Q8WYL5-1   Q8WYL5-2   Q8WYL5-3   Q8WYL5-4   Q8WYL5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSH1: NX_Q8WYL5

Explore proteomics data for SSH1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is
    decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and
    activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WYL5

  • SSH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSH1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001154802.1  NP_001154803.1  NP_061857.3  

    ENSEMBL proteins: 
     ENSP00000315713   ENSP00000447629   ENSP00000448824   ENSP00000326107   ENSP00000448586  
     ENSP00000446652   ENSP00000353374  

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    Cloud-Clone Corp. Proteins for SSH1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA14645219
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IDA14645219
    GO:0030027lamellipodium IEA--
    GO:0030496midbody IEA--

    SSH1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DUSPS: Protein tyrosine phosphatases / Class I Cys-based PTPs : Slingshots

    5/8 InterPro protein domains (see all 8):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR014876 DEK_C
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q8WYL5

    ProtoNet protein and cluster: Q8WYL5

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    SSH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSH1_HUMAN, Q8WYL5
    Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
    binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
    disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
    inactivated by this protein
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IDA11832213
    GO:0004721phosphoprotein phosphatase activity IMP19000834
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI15159416
         
    SSH1 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    2CXCR4-mediated signaling events
    CXCR4-mediated signaling events
    3FGF signaling pathway
    FGF signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for SSH1
        Regulation of Actin Cytoskeleton
    CXCR4-mediated signaling events
    FGF signaling pathway


    1         Kegg Pathway  (Kegg details for SSH1):
        Regulation of actin cytoskeleton


    SSH1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/20 Interacting proteins for SSH1 (Q8WYL51, 2, 3 ENSP000003157134) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-8006699 MINT-8006692 MINT-8008870 I2D: score=1 STRING: ENSP00000300161
    CFL1P235282, 3, ENSP000003096294MINT-8185692 MINT-8185710 I2D: score=4 STRING: ENSP00000309629
    CORO1BQ9BR761, 3, ENSP000003402114EBI-1222387,EBI-351152 I2D: score=2 STRING: ENSP00000340211
    YWHAQP273482, 3, ENSP000002380814MINT-8008916 I2D: score=1 STRING: ENSP00000238081
    YWHAZP631042, 3, ENSP000003095034MINT-8008923 I2D: score=4 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IMP14645219
    GO:0006470protein dephosphorylation IMP11832213
    GO:0008064regulation of actin polymerization or depolymerization IBA--
    GO:0010591regulation of lamellipodium assembly IBA--
    GO:0016311dephosphorylation ----

    SSH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSH1

    1 HMDB Compound for SSH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--

    Search CenterWatch for drugs/clinical trials and news about SSH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSH1 gene (3 alternative transcripts): 
    NM_001161330.1  NM_001161331.1  NM_018984.3  

    Unigene Cluster for SSH1:

    Slingshot protein phosphatase 1
    Hs.199763  [show with all ESTs]
    Unigene Representative Sequence: NM_018984
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326495(uc001tnm.3) ENST00000546433 ENST00000551165(uc001tnn.4)
    ENST00000326470(uc010sxg.2) ENST00000547862(uc001tno.1) ENST00000548522
    ENST00000547381 ENST00000546697 ENST00000546812 ENST00000360239(uc001tnl.3)

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    Additional mRNA sequence: 

    AB037719.1 AB072355.1 AB072356.1 AB072357.1 AK025581.1 AK095421.1 BC005101.1 BC013792.1 
    BC020243.1 BC062341.1 

    12 DOTS entries:

    DT.455121  DT.100736574  DT.40192573  DT.97791344  DT.99936175  DT.100762767  DT.91685765  DT.121191769 
    DT.91882424  DT.95253954  DT.121191815  DT.97763549 

    24/231 AceView cDNA sequences (see all 231):

    AI753519 AI659758 BQ893338 AI086341 CR623842 AI962661 BF593030 AA234310 
    BQ929507 AW006348 AB037719 AI799390 AK025581 BC005101 AI288068 CK299216 
    AI825194 CK000619 AI457799 AA424975 BE793092 AB072355 AA410509 BM674139 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:                          -     -                 -           -                                   -                                         -     -         
    SP2:                          -     -                 -           -                                   -                                                         
    SP3:                                -                 -           -                                   -                                                         
    SP4:                          -     -     -           -           -                                                                                             
    SP5:                                            -     -           -                                                                                             


    ECgene alternative splicing isoforms for SSH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSH1 expression in normal human tissues (normalized intensities)      SSH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGTTTGG
    SSH1 Expression
    About this image


    SSH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retinal Pigmented Epithelium
             optic nerve head astrocytes   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Human Brain Vascular Pericyte (HBVP)   
             optic nerve head astrocytes   
     
     Ovary (Reproductive System)
             oocyte   
     
     Endothelium (Cardiovascular System)
             cd31+ cells   
     
     Uterus (Reproductive System)
             endometrial endothelial cell   

    See SSH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSH1

    SOURCE GeneReport for Unigene cluster: Hs.199763
        SABiosciences Expression via Pathway-Focused PCR Arrays including SSH1: 
              Cytoskeleton Regulators in human mouse rat
              Protein Phosphatases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SSH1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssh11 , 5 slingshot homolog 1 (Drosophila)1, 5 82.83(n)1
    84.74(a)1
      5 (55.82 cM)5
    2316371  NM_198109.41  NP_932777.21 
     1139370945 
    chicken
    (Gallus gallus)
    Aves SSH16
    Uncharacterized protein
    69(a)
    1 ↔ 1
    15(6570787-6598063)
    lizard
    (Anolis carolinensis)
    Reptilia SSH16
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL344393.1(231-15325)
    African clawed frog
    (Xenopus laevis)
    Amphibia SSH2 slingshot-related protein 75.32(n)    AY233266.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ssh1b1 slingshot homolog 1b (Drosophila) 59.16(n)
    58.47(a)
      567479  XM_690775.3  XP_695867.2 


    ENSEMBL Gene Tree for SSH1 (if available)
    TreeFam Gene Tree for SSH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSH1 gene
    DUSP42  DUSP212  SSH22  DUSP102  DUSP62  DUSP142  DUSP282  DUSP82  
    DUSP72  DUSP52  SSH32  DUSP162  DUSP92  DUSP22  DUSP182  DUSP12  
    7 SIMAP similar genes for SSH1 using alignment to 4 protein entries:     SSH1_HUMAN (see all proteins):
    SSH2    SSH3    DUSP19    DUSP3    DUSP28    DUSP14
    DUSP22

    SSH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1602 SNPs in SSH1 are shown (see all 1602)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396416921,2
    --109017635(+) AGTGCA/TCACCT 1 -- ds50010--------
    rs1499403481,2
    --109017666(+) TGTACA/GGGAAG 1 -- ds50010--------
    rs1153940921,2
    C,F--109017736(+) AAGGAC/ACACCC 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1450096391,2
    --109017912(+) AATGAC/TGATGA 1 -- ds50010--------
    rs1489481121,2
    --109017924(+) GATGAC/TGATGT 1 -- ds50010--------
    rs758416041,2
    C--109017952(+) AGGGC-/GGAGGA 1 -- ds50010--------
    rs595703011,2
    C--109017953(+) GGGCT-/GAGGAA 1 -- ds50010--------
    rs1428720731,2
    C--109017974(+) TTTATA/GTAAAC 1 -- ds50010--------
    rs1869455881,2
    --109018185(+) TTAACA/GCAATT 1 -- ut310--------
    rs1911862691,2
    --109018367(+) GAAGAA/GTATGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SSH1 (109176466 - 109251366 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SSH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422361CNV Duplication17116639
    esv274226CNV Insertion20981092
    esv24121CNV Loss19812545


    Human Gene Mutation Database (HGMD): SSH1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SSH1
    DNA2.0 Custom Variant and Variant Library Synthesis for SSH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606778    OMIM disorders: --

    3 diseases for SSH1:    About MalaCards
    porokeratosis    keratosis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for SSH1:
    Keratosis     Mucoepidermoid carcinoma

    SSH1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SSH1
    Human Genome Epidemiology (HuGE) Navigator: SSH1 (1 document)

    Export disorders for SSH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSH1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with SSH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (2002)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2, 9 Nagata-Ohashi K.... Mizuno K. (2004)
    4. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2, 9 Wang Y.... Mizuno K. (2005)
    5. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. (PubMed id 12807904)1, 2, 9 Kaji N.... Mizuno K. (2003)
    6. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. (PubMed id 12684437)1, 2, 9 Endo M....Mizuno K. (2003)
    7. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 9 Soosairajah J.... Bernard O. (2005)
    8. Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. (PubMed id 16230460)1, 2, 9 Nishita M.... Mizuno K. (2005)
    9. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with mi crosatellite instability. (PubMed id 20477815)1, 4 Song S.Y....Lee S.H. (2010)
    10. Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. (PubMed id 14645219)1, 2 Nishita M....Mizuno K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54434 HGNC: 30579 AceView: SSH1 Ensembl:ENSG00000084112 euGenes: HUgn54434
    ECgene: SSH1 Kegg: 54434 H-InvDB: SSH1

    (According to HUGE)
    About This Section
    HUGE: KIAA1298

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSH1 gene:
    Search GeneIP for patents involving SSH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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