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Aliases for SSH1 Gene

Aliases for SSH1 Gene

  • Slingshot Protein Phosphatase 1 2 3 5
  • SSH-Like Protein 1 3 4
  • HSSH-1L 3 4
  • SSH1L 3 4
  • Slingshot Homolog 1 (Drosophila) 2
  • Slingshot Homolog 1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • KIAA1298 4
  • SSH-1L 4

External Ids for SSH1 Gene

Previous GeneCards Identifiers for SSH1 Gene

  • GC12M108286
  • GC12M109057
  • GC12M109111
  • GC12M107681
  • GC12M107683
  • GC12M107705
  • GC12M109180
  • GC12M106241
  • GC12M108779
  • GC12M108780

Summaries for SSH1 Gene

Entrez Gene Summary for SSH1 Gene

  • The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SSH1 Gene

SSH1 (Slingshot Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with SSH1 include porokeratosis. Among its related pathways are Regulation of actin cytoskeleton and Axon guidance. GO annotations related to this gene include actin binding and protein tyrosine phosphatase activity. An important paralog of this gene is SSH3.

UniProtKB/Swiss-Prot for SSH1 Gene

  • Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Gene Wiki entry for SSH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH1 Gene

Genomics for SSH1 Gene

Regulatory Elements for SSH1 Gene

Promoters for SSH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSH1 Gene

Chromosome:
12
Start:
108,778,192 bp from pter
End:
108,857,590 bp from pter
Size:
79,399 bases
Orientation:
Minus strand

Genomic View for SSH1 Gene

Genes around SSH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH1 Gene

Proteins for SSH1 Gene

  • Protein details for SSH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYL5-SSH1_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 1
    Protein Accession:
    Q8WYL5
    Secondary Accessions:
    • Q6P6C0
    • Q8N9A7
    • Q8WYL3
    • Q8WYL4
    • Q9P2P8

    Protein attributes for SSH1 Gene

    Size:
    1049 amino acids
    Molecular mass:
    115511 Da
    Quaternary structure:
    • Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date.
    SequenceCaution:
    • Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SSH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH1 Gene

Proteomics data for SSH1 Gene at MOPED

Post-translational modifications for SSH1 Gene

  • Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH1 Gene

Domains & Families for SSH1 Gene

Gene Families for SSH1 Gene

Suggested Antigen Peptide Sequences for SSH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WYL5

UniProtKB/Swiss-Prot:

SSH1_HUMAN :
  • Contains 1 tyrosine-protein phosphatase domain.
  • Belongs to the protein-tyrosine phosphatase family.
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.
Family:
  • Belongs to the protein-tyrosine phosphatase family.
genes like me logo Genes that share domains with SSH1: view

Function for SSH1 Gene

Molecular function for SSH1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot Function:
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Enzyme Numbers (IUBMB) for SSH1 Gene

Gene Ontology (GO) - Molecular Function for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 11832213
GO:0005515 protein binding IPI 15159416
genes like me logo Genes that share ontologies with SSH1: view
genes like me logo Genes that share phenotypes with SSH1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SSH1

miRNA for SSH1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSH1 Gene

Localization for SSH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH1 Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSH1 Gene COMPARTMENTS Subcellular localization image for SSH1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 14645219
GO:0005856 cytoskeleton IEA --
GO:0030496 midbody IEA --
genes like me logo Genes that share ontologies with SSH1: view

Pathways & Interactions for SSH1 Gene

genes like me logo Genes that share pathways with SSH1: view

Pathways by source for SSH1 Gene

SIGNOR curated interactions for SSH1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IMP 11832213
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0050770 regulation of axonogenesis IBA --
GO:0071318 cellular response to ATP IDA 19000834
genes like me logo Genes that share ontologies with SSH1: view

Drugs & Compounds for SSH1 Gene

(3) Additional Compounds for SSH1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with SSH1: view

Transcripts for SSH1 Gene

Unigene Clusters for SSH1 Gene

Slingshot protein phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for SSH1 Gene

GeneLoc Exon Structure for
SSH1
ECgene alternative splicing isoforms for
SSH1

Expression for SSH1 Gene

mRNA expression in normal human tissues for SSH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSH1 Gene

This gene is overexpressed in Spinal cord (35.4), Peripheral blood mononuclear cells (10.1), and Heart (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSH1 Gene



SOURCE GeneReport for Unigene cluster for SSH1 Gene Hs.199763

genes like me logo Genes that share expression patterns with SSH1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SSH1 Gene

Orthologs for SSH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSH1 35
  • 97.07 (n)
  • 96.49 (a)
cow
(Bos Taurus)
Mammalia SSH1 36
  • 83 (a)
OneToOne
SSH1 35
  • 83.99 (n)
  • 83.82 (a)
dog
(Canis familiaris)
Mammalia SSH1 35
  • 86.13 (n)
  • 85.4 (a)
SSH1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssh1 16
Ssh1 35
  • 82.41 (n)
  • 84.35 (a)
Ssh1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SSH1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssh1 35
  • 81.59 (n)
  • 82.66 (a)
chicken
(Gallus gallus)
Aves SSH1 35
  • 71.86 (n)
  • 72.12 (a)
SSH1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSH1 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia SSH 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssh1 35
  • 63.97 (n)
  • 64.32 (a)
zebrafish
(Danio rerio)
Actinopterygii ssh1a 36
  • 50 (a)
OneToMany
ssh1b 36
  • 53 (a)
OneToMany
LOC101885659 35
  • 65.29 (n)
  • 69.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta ssh 37
  • 51 (a)
ssh 36
  • 27 (a)
OneToMany
Species with no ortholog for SSH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH1 Gene

ENSEMBL:
Gene Tree for SSH1 (if available)
TreeFam:
Gene Tree for SSH1 (if available)

Paralogs for SSH1 Gene

Paralogs for SSH1 Gene

(7) SIMAP similar genes for SSH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SSH1: view

Variants for SSH1 Gene

Sequence variations from dbSNP and Humsavar for SSH1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs888531 -- 108,826,613(+) GTCTC(C/T)GTGAC intron-variant
rs769147 -- 108,823,960(-) ATGGC(C/T)GGGCG intron-variant, upstream-variant-2KB
rs987044 -- 108,856,580(+) CGTGA(A/G)ACACA intron-variant
rs2375014 -- 108,821,758(+) AATAT(C/T)ATCAA intron-variant
rs2375016 -- 108,834,138(+) CAGTA(C/T)TTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSH1 Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639
esv274226 CNV Insertion 20981092
esv24121 CNV Loss 19812545

Variation tolerance for SSH1 Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSH1 Gene

HapMap Linkage Disequilibrium report
SSH1
Human Gene Mutation Database (HGMD)
SSH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSH1 Gene

Disorders for SSH1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SSH1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
porokeratosis
  • disseminated superficial actinic porokeratosis
- elite association - COSMIC cancer census association via MalaCards
Search SSH1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSH1

Genetic Association Database (GAD)
SSH1
Human Genome Epidemiology (HuGE) Navigator
SSH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSH1
genes like me logo Genes that share disorders with SSH1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSH1 Gene

Publications for SSH1 Gene

  1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PMID: 11832213) Niwa R. … Uemura T. (Cell 2002) 2 3 4 67
  2. 14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes. (PMID: 19371722) Kligys K. … Jones J.C. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. Molecular dissection of the mechanisms of substrate recognition and F-actin-mediated activation of cofilin-phosphatase Slingshot-1. (PMID: 18809681) Kurita S. … Mizuno K. (J. Biol. Chem. 2008) 3 23
  4. Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells. (PMID: 18096821) San MartA-n A. … Griendling K.K. (Circ. Res. 2008) 3 23
  5. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PMID: 15671020) Wang Y. … Mizuno K. (J. Biol. Chem. 2005) 3 23

Products for SSH1 Gene

Sources for SSH1 Gene

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