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Aliases for SSH1 Gene

Aliases for SSH1 Gene

  • Slingshot Protein Phosphatase 1 2 3
  • SSH-Like Protein 1 3 4
  • KIAA1298 4 6
  • HSSH-1L 3 4
  • SSH1L 3 4
  • Protein Phosphatase Slingshot Homolog 1 3
  • Slingshot Homolog 1 (Drosophila) 2
  • Slingshot Homolog 1 3
  • EC 3.1.3.16 4
  • EC 3.1.3.48 4
  • SSH-1L 4

External Ids for SSH1 Gene

Summaries for SSH1 Gene

Entrez Gene Summary for SSH1 Gene

  • The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for SSH1 Gene

SSH1 (Slingshot Protein Phosphatase 1) is a Protein Coding gene. Diseases associated with SSH1 include porokeratosis. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP16.

UniProtKB/Swiss-Prot for SSH1 Gene

  • Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Gene Wiki entry for SSH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSH1 Gene

Genomics for SSH1 Gene

Genomic Location for SSH1 Gene

Start:
108,778,192 bp from pter
End:
108,857,590 bp from pter
Size:
79,399 bases
Orientation:
Minus strand

Genomic View for SSH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSH1 Gene

Regulatory Elements for SSH1 Gene

Proteins for SSH1 Gene

  • Protein details for SSH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYL5-SSH1_HUMAN
    Recommended name:
    Protein phosphatase Slingshot homolog 1
    Protein Accession:
    Q8WYL5
    Secondary Accessions:
    • Q6P6C0
    • Q8N9A7
    • Q8WYL3
    • Q8WYL4
    • Q9P2P8

    Protein attributes for SSH1 Gene

    Size:
    1049 amino acids
    Molecular mass:
    115511 Da
    Quaternary structure:
    • Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also blocks recruitment to lamellipodia and stimulation by actin.
    Miscellaneous:
    • Tyrosine phosphatase activity has not been demonstrated for this protein to date
    SequenceCaution:
    • Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SSH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSH1 Gene

Proteomics data for SSH1 Gene at MOPED

Post-translational modifications for SSH1 Gene

  • Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSH1 Gene

Domains for SSH1 Gene

Gene Families for SSH1 Gene

HGNC:
  • DUSPS :Protein tyrosine phosphatases / Class I Cys-based PTPs : Slingshots

UniProtKB/Swiss-Prot:

SSH1_HUMAN
Domain:
  • Contains 1 tyrosine-protein phosphatase domain.:
    • Q8WYL5
Family:
  • Belongs to the protein-tyrosine phosphatase family.:
    • Q8WYL5
genes like me logo Genes that share domains with SSH1: view

Function for SSH1 Gene

Molecular function for SSH1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
UniProtKB/Swiss-Prot Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

Enzyme Numbers (IUBMB) for SSH1 Gene

Gene Ontology (GO) - Molecular Function for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003779 actin binding IDA 11832213
GO:0004721 phosphoprotein phosphatase activity IMP 19000834
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 15159416
genes like me logo Genes that share ontologies with SSH1: view

miRNA for SSH1 Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SSH1 Gene

Localization for SSH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSH1 Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSH1 Gene COMPARTMENTS Subcellular localization image for SSH1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with SSH1: view

Pathways for SSH1 Gene

genes like me logo Genes that share pathways with SSH1: view

Pathways by source for SSH1 Gene

Gene Ontology (GO) - Biological Process for SSH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IMP 14645219
GO:0006470 protein dephosphorylation IMP 11832213
GO:0008064 regulation of actin polymerization or depolymerization IBA --
GO:0010591 regulation of lamellipodium assembly IBA --
GO:0016311 dephosphorylation --
genes like me logo Genes that share ontologies with SSH1: view

Compounds for SSH1 Gene

(1) HMDB Compounds for SSH1 Gene

Compound Synonyms Cas Number PubMed IDs
Phosphate
  • NFB Orthophosphate
14265-44-2
genes like me logo Genes that share compounds with SSH1: view

Transcripts for SSH1 Gene

Unigene Clusters for SSH1 Gene

Slingshot protein phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8:

Relevant External Links for SSH1 Gene

GeneLoc Exon Structure for
SSH1
ECgene alternative splicing isoforms for
SSH1

Expression for SSH1 Gene

mRNA expression in normal human tissues for SSH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSH1 Gene

SOURCE GeneReport for Unigene cluster for SSH1 Gene Hs.199763

genes like me logo Genes that share expressions with SSH1: view

Orthologs for SSH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSH1 36
  • 97.07 (n)
  • 96.49 (a)
cow
(Bos Taurus)
Mammalia SSH1 36
  • 83.99 (n)
  • 83.82 (a)
SSH1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSH1 36
  • 86.13 (n)
  • 85.4 (a)
SSH1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssh1 36
  • 82.41 (n)
  • 84.35 (a)
Ssh1 16
Ssh1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SSH1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssh1 36
  • 81.59 (n)
  • 82.66 (a)
chicken
(Gallus gallus)
Aves SSH1 36
  • 71.86 (n)
  • 72.12 (a)
SSH1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSH1 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia SSH 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ssh1 36
  • 63.97 (n)
  • 64.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885659 36
  • 65.29 (n)
  • 69.19 (a)
ssh1a 37
  • 50 (a)
OneToMany
ssh1b 37
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ssh 37
  • 27 (a)
OneToMany
ssh 38
  • 51 (a)
Species with no ortholog for SSH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSH1 Gene

ENSEMBL:
Gene Tree for SSH1 (if available)
TreeFam:
Gene Tree for SSH1 (if available)

Paralogs for SSH1 Gene

Paralogs for SSH1 Gene

Selected SIMAP similar genes for SSH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SSH1: view

Variants for SSH1 Gene

Sequence variations from dbSNP and Humsavar for SSH1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs769147 -- 108,823,960(-) ATGGC(C/T)GGGCG intron-variant
rs881179 -- 108,784,949(+) CTTTC(C/T)TGTGC utr-variant-3-prime
rs888531 -- 108,826,613(+) GTCTC(C/T)GTGAC intron-variant
rs933631 -- 108,789,308(+) AACAT(A/G)AGGGT intron-variant
rs987044 -- 108,856,580(+) CGTGA(A/G)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSH1 Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639
esv274226 CNV Insertion 20981092
esv24121 CNV Loss 19812545

Relevant External Links for SSH1 Gene

HapMap Linkage Disequilibrium report
SSH1
Human Gene Mutation Database (HGMD)
SSH1

Disorders for SSH1 Gene

(1) MalaCards Diseases for SSH1 Gene

Search for SSH1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SSH1 Gene

Relevant External Links for SSH1

Genetic Association Database (GAD)
SSH1
Human Genome Epidemiology (HuGE) Navigator
SSH1
genes like me logo Genes that share disorders with SSH1: view

No data available for UniProtKB/Swiss-Prot for SSH1 Gene

Publications for SSH1 Gene

  1. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. (PMID: 12684437) Endo M. … Mizuno K. (J. Neurosci. 2003) 3 4 23
  2. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. (PMID: 12807904) Kaji N. … Mizuno K. (J. Biol. Chem. 2003) 3 4 23
  3. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PMID: 15159416) Nagata-Ohashi K. … Mizuno K. (J. Cell Biol. 2004) 3 4 23
  4. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PMID: 15660133) Soosairajah J. … Bernard O. (EMBO J. 2005) 3 4 23
  5. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PMID: 15671020) Wang Y. … Mizuno K. (J. Biol. Chem. 2005) 3 4 23

Products for SSH1 Gene

Sources for SSH1 Gene

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