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SSH1 Gene

protein-coding   GIFtS: 61
GCID: GC12M109180

Slingshot Protein Phosphatase 1

(Previous name: slingshot homolog 1 (Drosophila))
  See SSH1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Slingshot Protein Phosphatase 11 2     Protein Phosphatase Slingshot Homolog 12
SSH1L2 3     Slingshot Homolog 12
hSSH-1L2 3     EC 3.1.3.163
SSH-Like Protein 12 3     EC 3.1.3.483
KIAA12983 5     SSH-1L3
Slingshot Homolog 1 (Drosophila)1     

External Ids:    HGNC: 305791   Entrez Gene: 544342   Ensembl: ENSG000000841127   OMIM: 6067785   UniProtKB: Q8WYL53   

Export aliases for SSH1 gene to outside databases

Previous GC identifers: GC12M108286 GC12M109057 GC12M109111 GC12M107681 GC12M107683 GC12M107705 GC12M106241


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSH1 Gene:
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate
actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor
cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by
kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins.
The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively
spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq,
Aug 2011)

GeneCards Summary for SSH1 Gene:
SSH1 (slingshot protein phosphatase 1) is a protein-coding gene. Diseases associated with SSH1 include porokeratosis. GO annotations related to this gene include actin binding and phosphoprotein phosphatase activity. An important paralog of this gene is DUSP4.

UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5
Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
inactivated by this protein

Gene Wiki entry for SSH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSH1 gene promoter:
         AP-2gamma   Egr-4   NF-AT   NF-AT4   NF-AT2   AP-2beta   NF-AT3   AP-2alpha   AP-2alphaA   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSH1 promoter sequence
   Search Chromatin IP Primers for SSH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.12

SSH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSH1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109180:  view genomic region     (about GC identifiers)

Start:
109,176,466 bp from pter      End:
109,251,366 bp from pter
Size:
74,901 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5 (See protein sequence)
Recommended Name: Protein phosphatase Slingshot homolog 1  
Size: 1049 amino acids; 115511 Da
Subunit: Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the
14-3-3 proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity
and also blocks recruitment to lamellipodia and stimulation by actin
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Sequence caution: Sequence=BAA92536.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q6P6C0 Q8N9A7 Q8WYL3 Q8WYL4 Q9P2P8
Alternative splicing: 5 isoforms:  Q8WYL5-1   Q8WYL5-2   Q8WYL5-3   Q8WYL5-4   Q8WYL5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SSH1: NX_Q8WYL5

Explore proteomics data for SSH1 at MOPED

Post-translational modifications: 

  • Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is
    decreased by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and
    activated by PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SSH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001154802.1  NP_001154803.1  NP_061857.3  

    ENSEMBL proteins: 
     ENSP00000315713   ENSP00000447629   ENSP00000448824   ENSP00000326107   ENSP00000448586  
     ENSP00000446652   ENSP00000353374  

    SSH1 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals SSH1 Proteins
    Novus Biologicals SSH1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSH1

     
    Search eBioscience for Proteins for SSH1 

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    Search for Antibodies for SSH1 at Abcam
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    LSBio Antibodies in human, mouse, rat for SSH1

    SSH1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SSH1
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    Search eBioscience for ELISAs for SSH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DUSPS: Protein tyrosine phosphatases / Class I Cys-based PTPs : Slingshots

    Selected InterPro protein domains (see all 8):
     IPR000387 Tyr/Dual-sp_Pase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR014876 DEK_C
     IPR016130 Tyr_Pase_AS
     IPR024950 DUSP

    Graphical View of Domain Structure for InterPro Entry Q8WYL5

    ProtoNet protein and cluster: Q8WYL5

    1 Blocks protein domain: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    Find genes that share domains with SSH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSH1_HUMAN, Q8WYL5
    Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
    binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their
    disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and
    inactivated by this protein
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.161 EC 3.1.3.481

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003779actin binding IDA11832213
    GO:0004721phosphoprotein phosphatase activity IMP19000834
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI15159416
         
    Find genes that share ontologies with SSH1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSH1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SSH1:
    hsa-mir-218-5p (MIRT024217), hsa-mir-26b-5p (MIRT030159), hsa-mir-877-3p (MIRT036943), hsa-mir-615-3p (MIRT040382)

    Block miRNA regulation of human, mouse, rat SSH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSH1 (see all 87):
    hsa-miR-607 hsa-miR-4254 hsa-miR-3938 hsa-miR-106a hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidSSH1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SSH1
    Predesigned siRNA for gene silencing in human, mouse, rat SSH1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SSH1 (see all 18)
    OriGene ORF clones in mouse, rat for SSH1
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    GenScript: all cDNA clones in your preferred vector (see all 3): SSH1 (NM_018984)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSH1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSH1_HUMAN, Q8WYL5: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also
    recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin
    dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with SSH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSH1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2FGF signaling pathway
    FGF signaling pathway
    3CXCR4-mediated signaling events
    CXCR4-mediated signaling events


    Find genes that share SuperPaths with SSH1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for SSH1
        Regulation of Actin Cytoskeleton
    FGF signaling pathway
    CXCR4-mediated signaling events


    1 Kegg Pathway  (Kegg details for SSH1):
        Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSH1: 
              Cytoskeleton Regulators in human mouse rat
              Protein Phosphatases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SSH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for SSH1 (Q8WYL51, 2, 3 ENSP000003157134) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIMK1P536671, 3, ENSP000003367404EBI-1222387,EBI-444403 I2D: score=4 STRING: ENSP00000336740
    YWHABP319461, 2, 3, ENSP000003001614EBI-1222387,EBI-359815 MINT-8006699 MINT-8006692 MINT-8008870 I2D: score=1 STRING: ENSP00000300161
    CFL1P235281, 2, 3, ENSP000003096294EBI-1222387,EBI-352733 MINT-8185692 MINT-8185710 I2D: score=4 STRING: ENSP00000309629
    YWHAQP273481, 2, 3, ENSP000002380814EBI-1222387,EBI-359854 MINT-8008916 I2D: score=1 STRING: ENSP00000238081
    CORO1BQ9BR761, 3, ENSP000003402114EBI-1222387,EBI-351152 I2D: score=2 STRING: ENSP00000340211
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IMP14645219
    GO:0006470protein dephosphorylation IMP11832213
    GO:0008064regulation of actin polymerization or depolymerization IBA--
    GO:0010591regulation of lamellipodium assembly IBA--
    GO:0016311dephosphorylation ----

    Find genes that share ontologies with SSH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSH1

    1 HMDB Compound for SSH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSH1 gene (3 alternative transcripts): 
    NM_001161330.1  NM_001161331.1  NM_018984.3  

    Unigene Cluster for SSH1:

    Slingshot protein phosphatase 1
    Hs.199763  [show with all ESTs]
    Unigene Representative Sequence: NM_018984
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326495(uc001tnm.3) ENST00000546433 ENST00000551165(uc001tnn.4)
    ENST00000326470(uc010sxg.2) ENST00000547862(uc001tno.1) ENST00000548522
    ENST00000547381 ENST00000546697 ENST00000546812 ENST00000360239(uc001tnl.3)

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    Block miRNA regulation of human, mouse, rat SSH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSH1 (see all 87):
    hsa-miR-607 hsa-miR-4254 hsa-miR-3938 hsa-miR-106a hsa-miR-128 hsa-miR-30d hsa-miR-578 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidSSH1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSH1
    Clone
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    OriGene clones in human, mouse for SSH1 (see all 18)
    OriGene ORF clones in mouse, rat for SSH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SSH1 (NM_018984)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSH1
    Primer
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    OriGene qPCR primer pairs and template standards for SSH1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSH1
      QuantiTect SYBR Green Assays in human, mouse, rat SSH1
      QuantiFast Probe-based Assays in human, mouse, rat SSH1

    Additional mRNA sequence: 

    AB037719.1 AB072355.1 AB072356.1 AB072357.1 AK025581.1 AK095421.1 BC005101.1 BC013792.1 
    BC020243.1 BC062341.1 

    12 DOTS entries:

    DT.455121  DT.100736574  DT.40192573  DT.97791344  DT.99936175  DT.100762767  DT.91685765  DT.121191769 
    DT.91882424  DT.95253954  DT.121191815  DT.97763549 

    Selected AceView cDNA sequences (see all 231):

    AW449167 BC020243 BQ772656 AI288068 BX508167 BQ431836 BU742742 BQ929507 
    AI333140 AA026327 AL121363 AI907409 BU617420 BQ448529 AI086341 AW006348 
    BQ681420 AA595731 BM701229 BU182778 CA447966 AL041728 BM674139 BX643818 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:                          -     -                 -           -                                   -                                         -     -         
    SP2:                          -     -                 -           -                                   -                                                         
    SP3:                                -                 -           -                                   -                                                         
    SP4:                          -     -     -           -           -                                                                                             
    SP5:                                            -     -           -                                                                                             


    ECgene alternative splicing isoforms for SSH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SSH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTGTTTGG
    SSH1 Expression
    About this image


    SSH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retinal Pigmented Epithelium
    SSH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199763
        Pathway & Disease-focused RT2 Profiler PCR Arrays including SSH1: 
              Cytoskeleton Regulators in human mouse rat
              Protein Phosphatases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SSH1
    OriGene qSTAR qPCR primer pairs in human, mouse for SSH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSH1
    QuantiTect SYBR Green Assays in human, mouse, rat SSH1
    QuantiFast Probe-based Assays in human, mouse, rat SSH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for SSH1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssh11 , 5 slingshot homolog 1 (Drosophila)1, 5 82.41(n)1
    84.35(a)1
      5 (55.82 cM)5
    2316371  NM_198109.41  NP_932777.21 
     1139370945 
    chicken
    (Gallus gallus)
    Aves SSH11 slingshot protein phosphatase 1 71.86(n)
    72.12(a)
      101750781  XM_004945616.1  XP_004945673.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSH16
    slingshot protein phosphatase 1
    60(a)
    1 ↔ 1
    GL344393.1(231-15325)
    African clawed frog
    (Xenopus laevis)
    Amphibia SSH2 slingshot-related protein 75.32(n)    AY233266.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018856591 protein phosphatase Slingshot homolog 1-like 65.29(n)
    69.19(a)
      101885659  XM_005165198.1  XP_005165255.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ssh3 regulation of actin polymerization
    and/or depolymerization more
    51(a)     --


    ENSEMBL Gene Tree for SSH1 (if available)
    TreeFam Gene Tree for SSH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSH1 gene
    DUSP42  SSH22  DUSP52  DUSP102  DUSP62  SSH32  DUSP162  DUSP92  
    DUSP22  DUSP82  DUSP12  DUSP72  
    7 SIMAP similar genes for SSH1 using alignment to 4 protein entries:     SSH1_HUMAN (see all proteins):
    SSH2    SSH3    DUSP19    DUSP3    DUSP28    DUSP14
    DUSP22

    Find genes that share paralogs with SSH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSH1 (see all 1602)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1396416921,2
    --109017635(+) AGTGCA/TCACCT 1 -- ds50010--------
    rs1499403481,2
    --109017666(+) TGTACA/GGGAAG 1 -- ds50010--------
    rs1153940921,2
    C,F--109017736(+) AAGGAC/ACACCC 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1450096391,2
    --109017912(+) AATGAC/TGATGA 1 -- ds50010--------
    rs1489481121,2
    --109017924(+) GATGAC/TGATGT 1 -- ds50010--------
    rs758416041,2
    C--109017952(+) AGGGC-/GGAGGA 1 -- ds50010--------
    rs595703011,2
    C--109017953(+) GGGCT-/GAGGAA 1 -- ds50010--------
    rs1428720731,2
    C--109017974(+) TTTATA/GTAAAC 1 -- ds50010--------
    rs1869455881,2
    --109018185(+) TTAACA/GCAATT 1 -- ut310--------
    rs1911862691,2
    --109018367(+) GAAGAA/GTATGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SSH1 (109176466 - 109251366 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SSH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422361CNV Duplication17116639
    esv274226CNV Insertion20981092
    esv24121CNV Loss19812545

    Human Gene Mutation Database (HGMD): SSH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSH1
    DNA2.0 Custom Variant and Variant Library Synthesis for SSH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606778    OMIM disorders: --

    1 disease for SSH1:    
    About MalaCards
    porokeratosis

    2 diseases from the University of Copenhagen DISEASES database for SSH1:
    Keratosis     Mucoepidermoid carcinoma

    Find genes that share disorders with SSH1           About GenesLikeMe

    Genetic Association Database (GAD): SSH1
    Human Genome Epidemiology (HuGE) Navigator: SSH1 (1 document)

    Export disorders for SSH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSH1 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with SSH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (Cell 2002)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2, 9 Nagata-Ohashi K.... Mizuno K. (J. Cell Biol. 2004)
    4. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2, 9 Wang Y.... Mizuno K. (J. Biol. Chem. 2005)
    5. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. (PubMed id 12807904)1, 2, 9 Kaji N.... Mizuno K. (J. Biol. Chem. 2003)
    6. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. (PubMed id 12684437)1, 2, 9 Endo M....Mizuno K. (J. Neurosci. 2003)
    7. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 9 Soosairajah J.... Bernard O. (EMBO J. 2005)
    8. Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. (PubMed id 16230460)1, 2, 9 Nishita M.... Mizuno K. (J. Cell Biol. 2005)
    9. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. (PubMed id 20477815)1, 4 Song S.Y....Lee S.H. (APMIS 2010)
    10. Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. (PubMed id 14645219)1, 2 Nishita M....Mizuno K. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54434 HGNC: 30579 AceView: SSH1 Ensembl:ENSG00000084112 euGenes: HUgn54434
    ECgene: SSH1 Kegg: 54434 H-InvDB: SSH1

    (According to HUGE)
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    HUGE: KIAA1298

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SSH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSH1 gene:
    Search GeneIP for patents involving SSH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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