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Aliases for SSFA2 Gene

Aliases for SSFA2 Gene

  • Sperm Specific Antigen 2 2 3
  • Cleavage Signal-1 Protein 2 3 4
  • Ki-Ras-Induced Actin-Interacting Protein 3 4
  • KRAS-Induced Actin-Interacting Protein 2 3
  • Sperm Associated Antigen 13 2 3
  • CS-1 3 4
  • KRAP 3 4
  • CS1 3 4
  • KIAA1927 4
  • SPAG13 3

External Ids for SSFA2 Gene

Previous GeneCards Identifiers for SSFA2 Gene

  • GC02P180990
  • GC02P181439
  • GC02P182720
  • GC02P182959
  • GC02P182582
  • GC02P182464
  • GC02P174612

Summaries for SSFA2 Gene

GeneCards Summary for SSFA2 Gene

SSFA2 (Sperm Specific Antigen 2) is a Protein Coding gene. GO annotations related to this gene include receptor binding and actin filament binding. An important paralog of this gene is TESPA1.

Gene Wiki entry for SSFA2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSFA2 Gene

Genomics for SSFA2 Gene

Regulatory Elements for SSFA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSFA2 Gene

181,891,716 bp from pter
181,930,738 bp from pter
39,023 bases
Plus strand

Genomic View for SSFA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSFA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSFA2 Gene

Proteins for SSFA2 Gene

  • Protein details for SSFA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sperm-specific antigen 2
    Protein Accession:
    Secondary Accessions:
    • A8K6T0
    • Q68DA6
    • Q7Z7L2
    • Q8N1L3
    • Q8N263
    • Q8N7H2
    • Q8NEN5
    • Q96E36
    • Q96PW1

    Protein attributes for SSFA2 Gene

    1259 amino acids
    Molecular mass:
    138386 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB00773.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12947.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB67820.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05308.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSFA2 Gene


neXtProt entry for SSFA2 Gene

Proteomics data for SSFA2 Gene at MOPED

Post-translational modifications for SSFA2 Gene

  • A 33 kDa peptide corresponding to the C-terminus of this protein is found in the testis and seems to be cleaved into 2 peptides of 14 kDa and 18 kDa found on the surface of mature sperm cells. This sperm surface antigen may be involved in some step of early cleavage of the fertilized oocyte
  • Ubiquitination at Lys 212
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for SSFA2
  • Santa Cruz Biotechnology (SCBT) Antibodies for SSFA2

No data available for DME Specific Peptides for SSFA2 Gene

Domains & Families for SSFA2 Gene

Protein Domains for SSFA2 Gene


Suggested Antigen Peptide Sequences for SSFA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSFA2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SSFA2 Gene

Function for SSFA2 Gene

Molecular function for SSFA2 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by activated KRAS.

Gene Ontology (GO) - Molecular Function for SSFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005102 receptor binding IEA --
GO:0051015 actin filament binding IDA 14673706
genes like me logo Genes that share ontologies with SSFA2: view
genes like me logo Genes that share phenotypes with SSFA2: view

Animal Models for SSFA2 Gene

MGI Knock Outs for SSFA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSFA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SSFA2 Gene

Localization for SSFA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSFA2 Gene

Cytoplasm. Note=Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions.

Subcellular locations from

Jensen Localization Image for SSFA2 Gene COMPARTMENTS Subcellular localization image for SSFA2 gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SSFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with SSFA2: view

Pathways & Interactions for SSFA2 Gene

SuperPathways for SSFA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSFA2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SSFA2 Gene

Drugs & Compounds for SSFA2 Gene

No Compound Related Data Available

Transcripts for SSFA2 Gene

Unigene Clusters for SSFA2 Gene

Sperm specific antigen 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSFA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSFA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^
SP1: -
SP3: - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: -

ExUns: 19a · 19b · 19c

Relevant External Links for SSFA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSFA2 Gene

mRNA expression in normal human tissues for SSFA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSFA2 Gene

This gene is overexpressed in Testis (14.2), Breast (11.7), Adrenal (10.1), and Cervix (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSFA2 Gene

SOURCE GeneReport for Unigene cluster for SSFA2 Gene Hs.196983

mRNA Expression by UniProt/SwissProt for SSFA2 Gene

Tissue specificity: Strongly expressed in pancreas and testis. Present in colon cancer cells (at protein level).
genes like me logo Genes that share expression patterns with SSFA2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SSFA2 Gene

Orthologs for SSFA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSFA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SSFA2 35
  • 88.76 (n)
  • 85.71 (a)
SSFA2 36
  • 84 (a)
(Canis familiaris)
Mammalia SSFA2 35
  • 86.8 (n)
  • 86.16 (a)
SSFA2 36
  • 86 (a)
(Mus musculus)
Mammalia Ssfa2 35
  • 81.43 (n)
  • 82.43 (a)
Ssfa2 16
Ssfa2 36
  • 82 (a)
(Pan troglodytes)
Mammalia SSFA2 35
  • 99.55 (n)
  • 99.36 (a)
SSFA2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ssfa2 35
  • 82.39 (n)
  • 82.9 (a)
(Monodelphis domestica)
Mammalia SSFA2 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SSFA2 36
  • 70 (a)
(Gallus gallus)
Aves SSFA2 35
  • 68.36 (n)
  • 64.36 (a)
SSFA2 36
  • 58 (a)
(Anolis carolinensis)
Reptilia SSFA2 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ssfa2 35
  • 61.23 (n)
  • 58.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18482 35
(Danio rerio)
Actinopterygii ssfa2 35
  • 50.13 (n)
  • 40 (a)
ssfa2 36
  • 30 (a)
Species with no ortholog for SSFA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSFA2 Gene

Gene Tree for SSFA2 (if available)
Gene Tree for SSFA2 (if available)

Paralogs for SSFA2 Gene

Paralogs for SSFA2 Gene

genes like me logo Genes that share paralogs with SSFA2: view

Variants for SSFA2 Gene

Sequence variations from dbSNP and Humsavar for SSFA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1051082 -- 181,922,083(+) CTTCT(A/G)TATGT missense, reference, nc-transcript-variant
rs1051085 -- 181,929,807(+) TGTCA(A/G)TATTT utr-variant-3-prime, nc-transcript-variant
rs1131495 -- 181,920,618(+) GAAGC(A/C/G/T)CTGAT missense, reference, intron-variant, nc-transcript-variant
rs2059702 -- 181,898,802(+) TAATT(A/T)GATTT intron-variant
rs2288330 -- 181,919,267(-) AAATT(G/T)GAAAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SSFA2 Gene

Variant ID Type Subtype PubMed ID
nsv834478 CNV Gain 17160897
nsv834479 CNV Gain 17160897

Variation tolerance for SSFA2 Gene

Residual Variation Intolerance Score: 45.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.73; 86.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSFA2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSFA2 Gene

Disorders for SSFA2 Gene

Relevant External Links for SSFA2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SSFA2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSFA2 Gene

Publications for SSFA2 Gene

  1. Human cleavage signal-1 protein; cDNA cloning, transcription and immunological analysis. (PMID: 1555770) Javed A.A. … Naz R.K. (Gene 1992) 2 23 67
  2. Sequence homology among sperm antigens involved in mammalian fertilization: search for a common epitope for immunocontraception. (PMID: 7529488) Zhu X. … Naz R.K. (Arch. Androl. 1994) 23 67
  3. Identification of serum-inducible genes: different patterns of gene regulation during G0->S and G1->S progression. (PMID: 8175911) Wick M. … Mueller R. (J. Cell Sci. 1994) 23 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 67

Products for SSFA2 Gene

Sources for SSFA2 Gene

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