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Aliases for SSFA2 Gene

Aliases for SSFA2 Gene

  • Sperm Specific Antigen 2 2 3
  • Cleavage Signal-1 Protein 2 3 4
  • CS1 3 4 6
  • Ki-Ras-Induced Actin-Interacting Protein 3 4
  • KRAS-Induced Actin-Interacting Protein 2 3
  • Sperm Associated Antigen 13 2 3
  • CS-1 3 4
  • KRAP 3 4
  • Sperm-Specific Antigen 2 3
  • KIAA1927 4
  • SPAG13 3

External Ids for SSFA2 Gene

Summaries for SSFA2 Gene

GeneCards Summary for SSFA2 Gene

SSFA2 (Sperm Specific Antigen 2) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is TESPA1.

Gene Wiki entry for SSFA2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSFA2 Gene

Genomics for SSFA2 Gene

Genomic Location for SSFA2 Gene

Start:
181,891,716 bp from pter
End:
181,930,738 bp from pter
Size:
39,023 bases
Orientation:
Plus strand

Genomic View for SSFA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSFA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSFA2 Gene

Regulatory Elements for SSFA2 Gene

Proteins for SSFA2 Gene

  • Protein details for SSFA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28290-SSFA2_HUMAN
    Recommended name:
    Sperm-specific antigen 2
    Protein Accession:
    P28290
    Secondary Accessions:
    • A8K6T0
    • Q68DA6
    • Q7Z7L2
    • Q8N1L3
    • Q8N263
    • Q8N7H2
    • Q8NEN5
    • Q96E36
    • Q96PW1

    Protein attributes for SSFA2 Gene

    Size:
    1259 amino acids
    Molecular mass:
    138386 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB00773.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12947.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB67820.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05308.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SSFA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSFA2 Gene

Proteomics data for SSFA2 Gene at MOPED

Post-translational modifications for SSFA2 Gene

  • A 33 kDa peptide corresponding to the C-terminus of this protein is found in the testis and seems to be cleaved into 2 peptides of 14 kDa and 18 kDa found on the surface of mature sperm cells. This sperm surface antigen may be involved in some step of early cleavage of the fertilized oocyte
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys212

No data available for DME Specific Peptides for SSFA2 Gene

Domains for SSFA2 Gene

Protein Domains for SSFA2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SSFA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSFA2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SSFA2 Gene

Function for SSFA2 Gene

Molecular function for SSFA2 Gene

UniProtKB/Swiss-Prot Induction: Up-regulated by activated KRAS.

Gene Ontology (GO) - Molecular Function for SSFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005102 receptor binding IEA --
GO:0051015 actin filament binding IDA 14673706
genes like me logo Genes that share ontologies with SSFA2: view
genes like me logo Genes that share phenotypes with SSFA2: view

Animal Models for SSFA2 Gene

MGI Knock Outs for SSFA2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SSFA2 Gene

Localization for SSFA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSFA2 Gene

Cytoplasm. Note=Located near the plasma membrane. Associated with actin filaments. May also exist as a membrane-bound form with extracellular regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSFA2 Gene COMPARTMENTS Subcellular localization image for SSFA2 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SSFA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with SSFA2: view

Pathways for SSFA2 Gene

SuperPathways for SSFA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSFA2 Gene

None

No data available for Pathways by source for SSFA2 Gene

Transcripts for SSFA2 Gene

Unigene Clusters for SSFA2 Gene

Sperm specific antigen 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSFA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^
SP1: -
SP2:
SP3: - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: -

ExUns: 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for SSFA2 Gene

GeneLoc Exon Structure for
SSFA2
ECgene alternative splicing isoforms for
SSFA2

Expression for SSFA2 Gene

mRNA expression in normal human tissues for SSFA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSFA2 Gene

SOURCE GeneReport for Unigene cluster for SSFA2 Gene Hs.196983

mRNA Expression by UniProt/SwissProt for SSFA2 Gene

P28290-SSFA2_HUMAN
Tissue specificity: Strongly expressed in pancreas and testis. Present in colon cancer cells (at protein level).
genes like me logo Genes that share expressions with SSFA2: view

No data available for mRNA differential expression in normal tissues for SSFA2 Gene

Orthologs for SSFA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSFA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSFA2 35
  • 99.55 (n)
  • 99.36 (a)
SSFA2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSFA2 35
  • 88.76 (n)
  • 85.71 (a)
SSFA2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSFA2 35
  • 86.8 (n)
  • 86.16 (a)
SSFA2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssfa2 35
  • 81.43 (n)
  • 82.43 (a)
Ssfa2 16
Ssfa2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSFA2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSFA2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssfa2 35
  • 82.39 (n)
  • 82.9 (a)
chicken
(Gallus gallus)
Aves SSFA2 35
  • 68.36 (n)
  • 64.36 (a)
SSFA2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSFA2 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18482 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssfa2 35
  • 61.23 (n)
  • 58.29 (a)
zebrafish
(Danio rerio)
Actinopterygii ssfa2 35
  • 50.13 (n)
  • 40 (a)
ssfa2 36
  • 30 (a)
OneToOne
Species with no ortholog for SSFA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSFA2 Gene

ENSEMBL:
Gene Tree for SSFA2 (if available)
TreeFam:
Gene Tree for SSFA2 (if available)

Paralogs for SSFA2 Gene

Paralogs for SSFA2 Gene

genes like me logo Genes that share paralogs with SSFA2: view

Variants for SSFA2 Gene

Sequence variations from dbSNP and Humsavar for SSFA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1051082 -- 181,922,083(+) CTTCT(A/G)TATGT missense, reference, nc-transcript-variant
rs1051085 -- 181,929,807(+) TGTCA(A/G)TATTT utr-variant-3-prime, nc-transcript-variant
rs1131495 -- 181,920,618(+) GAAGC(A/C/G)CTGAT missense, reference, intron-variant, nc-transcript-variant
rs2059702 -- 181,898,802(+) TAATT(A/T)GATTT intron-variant
rs2288330 -- 181,919,267(-) AAATT(G/T)GAAAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SSFA2 Gene

Variant ID Type Subtype PubMed ID
nsv834478 CNV Gain 17160897
nsv834479 CNV Gain 17160897

Relevant External Links for SSFA2 Gene

HapMap Linkage Disequilibrium report
SSFA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSFA2 Gene

Disorders for SSFA2 Gene

Relevant External Links for SSFA2

Genetic Association Database (GAD)
SSFA2
genes like me logo Genes that share disorders with SSFA2: view

No data available for UniProtKB/Swiss-Prot for SSFA2 Gene

Publications for SSFA2 Gene

  1. Human cleavage signal-1 protein; cDNA cloning, transcription and immunological analysis. (PMID: 1555770) Javed A.A. … Naz R.K. (Gene 1992) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. Deregulated expression of KRAP, a novel gene encoding actin- interacting protein, in human colon cancer cells. (PMID: 14673706) Inokuchi J. … Shirasawa S. (J. Hum. Genet. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SSFA2 Gene

Sources for SSFA2 Gene

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