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Aliases for SSC4D Gene

Aliases for SSC4D Gene

  • Scavenger Receptor Cysteine Rich Family, 4 Domains 2 3
  • Scavenger Receptor Cysteine Rich Domain Containing, Group B (4 Domains) 2 3
  • Four Scavenger Receptor Cysteine-Rich Domains-Containing Protein 3 4
  • Scavenger Receptor Cysteine-Rich Protein SRCRB-S4D 2 3
  • S4D-SRCRB 3 4
  • SRCRB4D 3 4
  • SRCRB-S4D 3
  • S4-SRCRB 3

External Ids for SSC4D Gene

Previous HGNC Symbols for SSC4D Gene


Summaries for SSC4D Gene

Entrez Gene Summary for SSC4D Gene

  • The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.[supplied by OMIM, Apr 2004]

GeneCards Summary for SSC4D Gene

SSC4D (Scavenger Receptor Cysteine Rich Family, 4 Domains) is a Protein Coding gene. GO annotations related to this gene include scavenger receptor activity. An important paralog of this gene is LOXL1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSC4D Gene

Genomics for SSC4D Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSC4D Gene

76,389,329 bp from pter
76,409,695 bp from pter
20,367 bases
Minus strand

Genomic View for SSC4D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSC4D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSC4D Gene

No data available for Regulatory Elements for SSC4D Gene

Proteins for SSC4D Gene

  • Protein details for SSC4D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Scavenger receptor cysteine-rich domain-containing group B protein
    Protein Accession:
    Secondary Accessions:
    • Q2HIZ5
    • Q6ZMG3
    • Q96BF5

    Protein attributes for SSC4D Gene

    575 amino acids
    Molecular mass:
    60819 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH15651.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAD18764.1; Type=Frameshift; Positions=25; Evidence={ECO:0000305};

    Alternative splice isoforms for SSC4D Gene


neXtProt entry for SSC4D Gene

Proteomics data for SSC4D Gene at MOPED

Post-translational modifications for SSC4D Gene

No Post-translational modifications

Other Protein References for SSC4D Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSC4D Gene

Domains & Families for SSC4D Gene

Protein Domains for SSC4D Gene


Suggested Antigen Peptide Sequences for SSC4D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 SRCR domains.
  • Contains 4 SRCR domains.
genes like me logo Genes that share domains with SSC4D: view

No data available for Gene Families for SSC4D Gene

Function for SSC4D Gene

Molecular function for SSC4D Gene

UniProtKB/Swiss-Prot Induction:
Not induced by a combination of IL1A/interleukin-1 alpha, IL6/interleukin-6 and dexamethasone.

Gene Ontology (GO) - Molecular Function for SSC4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with SSC4D: view

Phenotypes for SSC4D Gene

genes like me logo Genes that share phenotypes with SSC4D: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSC4D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SSC4D Gene

Localization for SSC4D Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSC4D Gene


Gene Ontology (GO) - Cellular Components for SSC4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SSC4D: view

No data available for Subcellular locations from COMPARTMENTS for SSC4D Gene

Pathways & Interactions for SSC4D Gene

SuperPathways for SSC4D Gene

No Data Available

Interacting Proteins for SSC4D Gene

Gene Ontology (GO) - Biological Process for SSC4D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with SSC4D: view

No data available for Pathways by source and SIGNOR curated interactions for SSC4D Gene

Drugs & Compounds for SSC4D Gene

No Compound Related Data Available

Transcripts for SSC4D Gene

mRNA/cDNA for SSC4D Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSC4D

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSC4D Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c
SP1: - - -
SP2: -

Relevant External Links for SSC4D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSC4D Gene

mRNA expression in normal human tissues for SSC4D Gene

genes like me logo Genes that share expression patterns with SSC4D: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SSC4D Gene

Orthologs for SSC4D Gene

This gene was present in the common ancestor of chordates.

Orthologs for SSC4D Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SRCRB4D 35
  • 88.64 (n)
  • 90.91 (a)
  • 89 (a)
(Canis familiaris)
Mammalia SRCRB4D 35
  • 87.98 (n)
  • 90.24 (a)
  • 88 (a)
(Mus musculus)
Mammalia Srcrb4d 35
  • 83.92 (n)
  • 88.46 (a)
Srcrb4d 16
Srcrb4d 36
  • 86 (a)
(Pan troglodytes)
Mammalia SRCRB4D 35
  • 99.19 (n)
  • 99.13 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Srcrb4d 35
  • 84.03 (n)
  • 88.64 (a)
(Monodelphis domestica)
Mammalia SRCRB4D 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia SRCRB4D 36
  • 55 (a)
(Gallus gallus)
Aves SRCRB4D 35
  • 68.78 (n)
  • 65.26 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia SRCRB4D 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia srcrb4d 35
  • 60.95 (n)
  • 62.96 (a)
(Danio rerio)
Actinopterygii LOC100331436 35
  • 61.61 (n)
  • 57.79 (a)
  • 35 (a)
Species with no ortholog for SSC4D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSC4D Gene

Gene Tree for SSC4D (if available)
Gene Tree for SSC4D (if available)

Paralogs for SSC4D Gene

Paralogs for SSC4D Gene

genes like me logo Genes that share paralogs with SSC4D: view

Variants for SSC4D Gene

Sequence variations from dbSNP and Humsavar for SSC4D Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs999096 -- 76,389,698(+) AGAGC(C/T)CCTGA utr-variant-3-prime
rs1558179 -- 76,391,084(-) AATCA(C/T)GGCCA intron-variant
rs1966268 -- 76,391,327(-) agtaa(C/G)tggga intron-variant
rs1966269 -- 76,391,233(-) tggtc(A/T)cgaac intron-variant
rs1966270 -- 76,391,147(-) cCCAT(C/G/T)TTATA intron-variant

Variation tolerance for SSC4D Gene

Residual Variation Intolerance Score: 83.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.39; 88.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSC4D Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SSC4D Gene

Disorders for SSC4D Gene

Relevant External Links for SSC4D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SSC4D: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSC4D Gene

Publications for SSC4D Gene

  1. Cloning of S4D-SRCRB, a new soluble member of the group B scavenger receptor cysteine-rich family (SRCR-SF) mapping to human chromosome 7q11.23. (PMID: 12466895) Padilla O. … Lozano F. (Immunogenetics 2002) 2 23 67
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  3. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz H.J. … Yaspo M.L. (J. Biol. Chem. 2011) 67
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for SSC4D Gene

Sources for SSC4D Gene

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