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Aliases for SSBP4 Gene

Aliases for SSBP4 Gene

  • Single Stranded DNA Binding Protein 4 2 3 5

External Ids for SSBP4 Gene

Previous GeneCards Identifiers for SSBP4 Gene

  • GC19P019023
  • GC19P018922
  • GC19P018375
  • GC19P018391
  • GC19P018531
  • GC19P018093
  • GC19P018644

Summaries for SSBP4 Gene

GeneCards Summary for SSBP4 Gene

SSBP4 (Single Stranded DNA Binding Protein 4) is a Protein Coding gene. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

Additional gene information for SSBP4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP4 Gene

Genomics for SSBP4 Gene

Regulatory Elements for SSBP4 Gene

Enhancers for SSBP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H018414 2.1 FANTOM5 Ensembl ENCODE dbSUPER 21.6 +0.0 34 9.2 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF143 ZNF207 NR2C2AP MAU2 ENSG00000268030 UPF1 KIAA1683 SSBP4 COLGALT1 ENSG00000268938 LOC100507551 ENSG00000268199
GH19H018512 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.9 +99.2 99150 10.5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ELL SSBP4 FKBP8 LRRC25 PGPEP1 IL12RB1 JUND KXD1 UPF1 IFI30
GH19H018472 2 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +58.6 58644 8.7 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 DEK PAF1 SSBP4 IFI30 NR2C2AP ELL ENSG00000268030 TMEM161A IL12RB1 JUND LRRC25 ARRDC2
GH19H018498 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +85.7 85651 11.8 FOXA2 MLX ARID4B DMAP1 YY1 ZNF121 GLIS2 GATA2 ZNF143 SP5 ELL SSBP4 FKBP8 KXD1 UBA52 REX1BD LRRC25 JUND IL12RB1 GC19M018475
GH19H018492 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +76.2 76206 5.7 NFIB ARID4B RAD21 RARA GLIS2 EGR1 EGR2 ZNF362 REST NR2F2 SSBP4 ELL FKBP8 UBA52 CRTC1 REX1BD ARRDC2 JUND IL12RB1 KLHL26
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SSBP4 on UCSC Golden Path with GeneCards custom track

Promoters for SSBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000287751 -861 401 PKNOX1 ARNT ARID4B ZNF2 ETS1 SLC30A9 ZNF143 ZNF207 ZNF548 ATF7
ENSR00000108070 1139 1201 ATF1 ARNT ZFP64 ARID4B SIN3A ZNF766 GLIS2 ELK1 ZNF143 ZNF207
ENSR00000287750 -1561 201 PKNOX1 ARNT SIN3A TCF12 GLIS2 SP3 SREBF1 MBD2 SSRP1 RFX3

Genomic Locations for SSBP4 Gene

Genomic Locations for SSBP4 Gene
chr19:18,418,661-18,434,562
(GRCh38/hg38)
Size:
15,902 bases
Orientation:
Plus strand
chr19:18,529,674-18,545,372
(GRCh37/hg19)

Genomic View for SSBP4 Gene

Genes around SSBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP4 Gene

Proteins for SSBP4 Gene

  • Protein details for SSBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWG4-SSBP4_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 4
    Protein Accession:
    Q9BWG4
    Secondary Accessions:
    • Q9BWW5

    Protein attributes for SSBP4 Gene

    Size:
    385 amino acids
    Molecular mass:
    39388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP4 Gene

Post-translational modifications for SSBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSBP4 Gene

Domains & Families for SSBP4 Gene

Gene Families for SSBP4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SSBP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SSBP4: view

No data available for UniProtKB/Swiss-Prot for SSBP4 Gene

Function for SSBP4 Gene

Phenotypes From GWAS Catalog for SSBP4 Gene

Gene Ontology (GO) - Molecular Function for SSBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SSBP4: view
genes like me logo Genes that share phenotypes with SSBP4: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSBP4 Gene

Localization for SSBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SSBP4 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SSBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SSBP4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SSBP4 Gene

Pathways & Interactions for SSBP4 Gene

SuperPathways for SSBP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with SSBP4: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP4 Gene

Drugs & Compounds for SSBP4 Gene

No Compound Related Data Available

Transcripts for SSBP4 Gene

Unigene Clusters for SSBP4 Gene

Single stranded DNA binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^
SP1: - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9:
SP10: - - - - -
SP11: - -
SP12: - - - - -
SP13:
SP14:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SSBP4 Gene

GeneLoc Exon Structure for
SSBP4
ECgene alternative splicing isoforms for
SSBP4

Expression for SSBP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SSBP4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSBP4 Gene



Protein tissue co-expression partners for SSBP4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSBP4 Gene:

SSBP4

SOURCE GeneReport for Unigene cluster for SSBP4 Gene:

Hs.515259

Evidence on tissue expression from TISSUES for SSBP4 Gene

  • Eye(4.2)
  • Nervous system(3.2)
  • Pancreas(2.9)
genes like me logo Genes that share expression patterns with SSBP4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSBP4 Gene

Orthologs for SSBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSBP4 33 34
  • 98.51 (n)
cow
(Bos Taurus)
Mammalia SSBP4 33 34
  • 91.25 (n)
dog
(Canis familiaris)
Mammalia SSBP4 33 34
  • 90.46 (n)
mouse
(Mus musculus)
Mammalia Ssbp4 33 16 34
  • 85.27 (n)
rat
(Rattus norvegicus)
Mammalia Ssbp4 33
  • 85.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP4 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSBP4 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488961 33
  • 72.33 (n)
zebrafish
(Danio rerio)
Actinopterygii SSBP4 (2 of 2) 34
  • 74 (a)
OneToMany
ssbp4 34 33
  • 73.09 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 34
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sam-10 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 34
  • 54 (a)
OneToMany
Species where no ortholog for SSBP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP4 Gene

ENSEMBL:
Gene Tree for SSBP4 (if available)
TreeFam:
Gene Tree for SSBP4 (if available)

Paralogs for SSBP4 Gene

Paralogs for SSBP4 Gene

(3) SIMAP similar genes for SSBP4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SSBP4: view

Variants for SSBP4 Gene

Sequence variations from dbSNP and Humsavar for SSBP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000114419 -- 18,427,552(+) CTGCA(A/G)GGTCC intron-variant
rs1000183561 -- 18,424,730(+) CCTTC(G/T)GTGTT intron-variant, upstream-variant-2KB
rs1000188673 -- 18,426,364(+) ACCCT(A/G)TCTTG intron-variant
rs1000197673 -- 18,421,901(+) GCCTA(A/T)AATCA intron-variant
rs1000212910 -- 18,424,888(+) GGGGT(A/G)GGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSBP4 Gene

Variant ID Type Subtype PubMed ID
esv2677302 CNV deletion 23128226
nsv1072337 CNV deletion 25765185
nsv1144870 CNV deletion 24896259
nsv952420 CNV deletion 24416366

Variation tolerance for SSBP4 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSBP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP4 Gene

Disorders for SSBP4 Gene

Relevant External Links for SSBP4

Genetic Association Database (GAD)
SSBP4
Human Genome Epidemiology (HuGE) Navigator
SSBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSBP4

No disorders were found for SSBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP4 Gene

Publications for SSBP4 Gene

  1. A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P … Nagarajan L (Genomics 2002) 2 3 4 60
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for SSBP4 Gene

Sources for SSBP4 Gene

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