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Aliases for SSBP4 Gene

Aliases for SSBP4 Gene

  • Single Stranded DNA Binding Protein 4 2 3 5

External Ids for SSBP4 Gene

Previous GeneCards Identifiers for SSBP4 Gene

  • GC19P019023
  • GC19P018922
  • GC19P018375
  • GC19P018391
  • GC19P018531
  • GC19P018093
  • GC19P018644

Summaries for SSBP4 Gene

GeneCards Summary for SSBP4 Gene

SSBP4 (Single Stranded DNA Binding Protein 4) is a Protein Coding gene. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP4 Gene

Genomics for SSBP4 Gene

Regulatory Elements for SSBP4 Gene

Enhancers for SSBP4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSBP4 on UCSC Golden Path with GeneCards custom track

Promoters for SSBP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSBP4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSBP4 Gene

Chromosome:
19
Start:
18,418,661 bp from pter
End:
18,434,562 bp from pter
Size:
15,902 bases
Orientation:
Plus strand

Genomic View for SSBP4 Gene

Genes around SSBP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP4 Gene

Proteins for SSBP4 Gene

  • Protein details for SSBP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWG4-SSBP4_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 4
    Protein Accession:
    Q9BWG4
    Secondary Accessions:
    • Q9BWW5

    Protein attributes for SSBP4 Gene

    Size:
    385 amino acids
    Molecular mass:
    39388 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP4 Gene

Proteomics data for SSBP4 Gene at MOPED

Post-translational modifications for SSBP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSBP4 Gene

Domains & Families for SSBP4 Gene

Suggested Antigen Peptide Sequences for SSBP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWG4

UniProtKB/Swiss-Prot:

SSBP4_HUMAN :
  • Contains 1 LisH domain.
Domain:
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with SSBP4: view

No data available for Gene Families for SSBP4 Gene

Function for SSBP4 Gene

Gene Ontology (GO) - Molecular Function for SSBP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with SSBP4: view
genes like me logo Genes that share phenotypes with SSBP4: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SSBP4 Gene

Localization for SSBP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSBP4 Gene COMPARTMENTS Subcellular localization image for SSBP4 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SSBP4 Gene

Pathways & Interactions for SSBP4 Gene

SuperPathways for SSBP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SSBP4 Gene

Drugs & Compounds for SSBP4 Gene

No Compound Related Data Available

Transcripts for SSBP4 Gene

Unigene Clusters for SSBP4 Gene

Single stranded DNA binding protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^
SP1: - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - -
SP4:
SP5: - - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9:
SP10: - - - - -
SP11: - -
SP12: - - - - -
SP13:
SP14:

ExUns: 20a · 20b ^ 21 ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SSBP4 Gene

GeneLoc Exon Structure for
SSBP4
ECgene alternative splicing isoforms for
SSBP4

Expression for SSBP4 Gene

mRNA expression in normal human tissues for SSBP4 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSBP4 Gene



SOURCE GeneReport for Unigene cluster for SSBP4 Gene Hs.515259

genes like me logo Genes that share expression patterns with SSBP4: view

Protein tissue co-expression partners for SSBP4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSBP4 Gene

Orthologs for SSBP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSBP4 35
  • 91.25 (n)
  • 95.03 (a)
SSBP4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp4 35
  • 85.27 (n)
  • 89.23 (a)
Ssbp4 16
Ssbp4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSBP4 35
  • 98.51 (n)
  • 98.63 (a)
SSBP4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSBP4 36
  • 94 (a)
OneToOne
SSBP4 35
  • 90.46 (n)
  • 95.83 (a)
oppossum
(Monodelphis domestica)
Mammalia SSBP4 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP4 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssbp4 35
  • 85.17 (n)
  • 88.4 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488961 35
  • 72.33 (n)
  • 81.62 (a)
zebrafish
(Danio rerio)
Actinopterygii ssbp4 35
  • 73.09 (n)
  • 81.28 (a)
ssbp4 36
  • 78 (a)
OneToMany
SSBP4 (2 of 2) 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sam-10 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 36
  • 54 (a)
OneToMany
Species with no ortholog for SSBP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP4 Gene

ENSEMBL:
Gene Tree for SSBP4 (if available)
TreeFam:
Gene Tree for SSBP4 (if available)

Paralogs for SSBP4 Gene

Paralogs for SSBP4 Gene

(3) SIMAP similar genes for SSBP4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SSBP4: view

Variants for SSBP4 Gene

Sequence variations from dbSNP and Humsavar for SSBP4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7258465 -- 18,422,832(+) AACCT(C/T)GACTC intron-variant
rs7507612 -- 18,422,186(+) aCAGT(C/G)AAAGA intron-variant
rs12980450 -- 18,433,504(+) GCTTG(A/C/T)GAGGG intron-variant
rs12984422 -- 18,417,053(+) GGCGC(A/C)TCAGC upstream-variant-2KB
rs13346832 -- 18,427,237(+) CTGCT(C/G)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP4 Gene

Variant ID Type Subtype PubMed ID
nsv911274 CNV Loss 21882294
nsv911275 CNV Loss 21882294
nsv911276 CNV Loss 21882294
dgv3782n71 CNV Loss 21882294
dgv3783n71 CNV Loss 21882294
esv2677302 CNV Deletion 23128226

Variation tolerance for SSBP4 Gene

Residual Variation Intolerance Score: 42.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSBP4 Gene

HapMap Linkage Disequilibrium report
SSBP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP4 Gene

Disorders for SSBP4 Gene

Relevant External Links for SSBP4

Genetic Association Database (GAD)
SSBP4
Human Genome Epidemiology (HuGE) Navigator
SSBP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSBP4

No disorders were found for SSBP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP4 Gene

Publications for SSBP4 Gene

  1. A novel, evolutionarily conserved gene family with putative sequence- specific single-stranded DNA-binding activity. (PMID: 12079286) Castro P.D. … Nagarajan L. (Genomics 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PMID: 23535729) Michailidou K. … Easton D.F. (Nat. Genet. 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for SSBP4 Gene

Sources for SSBP4 Gene

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