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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSBP3 Gene

protein-coding   GIFtS: 53
GCID: GC01M054692

Single Stranded DNA Binding Protein 3

(Previous name: single-stranded DNA-binding protein 3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Single Stranded DNA Binding Protein 31 2
Single-Stranded DNA-Binding Protein 31 2
Sequence-Specific Single-Stranded-DNA-Binding Protein2 3
SSDP2 3
SSDP12 3
CSDP2

External Ids:    HGNC: 156741   Entrez Gene: 236482   Ensembl: ENSG000001572167   OMIM: 6073905   UniProtKB: Q9BWW43   

Export aliases for SSBP3 gene to outside databases

Previous GC identifers: GC01M054521 GC01M053580 GC01M054049 GC01M054062 GC01M054404 GC01M054464 GC01M052807


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SSBP3 Gene: 
SSBP3 (single stranded DNA binding protein 3) is a protein-coding gene. Diseases associated with SSBP3 include thyroid lymphoma, and invasive aspergillosis. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4
Function: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the
single-stranded polypyrimidine sequences in the promoter region (By similarity)

Gene Wiki entry for SSBP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSBP3 gene promoter:
         E2F-1   E2F-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSBP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SSBP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

SSBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSBP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M054692:  view genomic region     (about GC identifiers)

Start:
54,691,105 bp from pter      End:
54,879,152 bp from pter
Size:
188,048 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4 (See protein sequence)
Recommended Name: Single-stranded DNA-binding protein 3  
Size: 388 amino acids; 40421 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8K0A9 Q5T860 Q5T861 Q9BTM0 Q9BWW3
Alternative splicing: 3 isoforms:  Q9BWW4-1   Q9BWW4-2   Q9BWW4-3   

Explore the universe of human proteins at neXtProt for SSBP3: NX_Q9BWW4

Explore proteomics data for SSBP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BWW4

  • SSBP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSBP3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001009955.1  NP_060540.2  NP_663768.1  

    ENSEMBL proteins: 
     ENSP00000414361   ENSP00000360371   ENSP00000360370   ENSP00000350067   ENSP00000405880  
     ENSP00000431654  

    Human Recombinant Protein Products for SSBP3: 
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    OriGene MassSpec for SSBP3 
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    Novus Biologicals SSBP3 Proteins
    Novus Biologicals SSBP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSBP3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0043234protein complex IEA--

    SSBP3 for ontologies           About GeneDecksing



    SSBP3 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SSBP3 

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    Cloud-Clone Corp. ELISAs for SSBP3 
    Cloud-Clone Corp. CLIAs for SSBP3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR008116 SSDP_DNA-bd
     IPR007591 SSDP_ss-bd
     IPR006594 LisH_dimerisation

    Graphical View of Domain Structure for InterPro Entry Q9BWW4

    ProtoNet protein and cluster: Q9BWW4

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB007591 Single-stranded DNA-binding protein


    UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4
    Similarity: Contains 1 LisH domain


    SSBP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSBP3_HUMAN, Q9BWW4
    Function: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the
    single-stranded polypyrimidine sequences in the promoter region (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003697single-stranded DNA binding IEA--
    GO:0005515protein binding ----
         
    SSBP3 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ssbp3):
     craniofacial  embryogenesis  growth/size  mortality/aging  nervous system 
     normal  skeleton 

    SSBP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSBP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSBP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSBP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSBP3 

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate SSBP3 (see all 26):
    hsa-miR-30c hsa-miR-676 hsa-miR-448 hsa-miR-137 hsa-miR-25 hsa-miR-30d hsa-miR-141* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSSBP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSBP3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): SSBP3 (NM_018070)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of SSBP3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSBP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SSBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/42 Interacting proteins for SSBP3 (Q9BWW43 ENSP000003603714) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    TAL1P175423, ENSP000002943394I2D: score=2 STRING: ENSP00000294339
    ASB3Q9Y5753I2D: score=1 
    GPR75-ASB3Q9Y5753I2D: score=1 
    HCLS1P143173, ENSP000003201764I2D: score=1 STRING: ENSP00000320176
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006461protein complex assembly IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0021501prechordal plate formation IEA--
    GO:0021547midbrain-hindbrain boundary initiation IEA--

    SSBP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SSBP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSBP3

    10/18 Novoseek inferred chemical compound relationships for SSBP3 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 42.5 12 12592413 (2), 2118997 (1), 9431812 (1), 14527952 (1) (see all 10)
    oligonucleotide 41.2 3 7999067 (1), 11713803 (1), 7964651 (1)
    leucine 26 3 1748630 (1), 16580748 (1), 11295448 (1)
    cytosine 14.5 1 16608167 (1)
    biotin 14.3 1 18586268 (1)
    bamhi 13 1 15196020 (1)
    polyacrylamide 2.47 1 18265085 (1)
    thymine 1.69 1 15134443 (1)
    atp 0 2 18719126 (1), 9882364 (1)
    threonine 0 1 2055486 (1)

    Search CenterWatch for drugs/clinical trials and news about SSBP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SSBP3 gene (3 alternative transcripts): 
    NM_001009955.3  NM_018070.4  NM_145716.3  

    Unigene Cluster for SSBP3:

    Single stranded DNA binding protein 3
    Hs.658676  [show with all ESTs]
    Unigene Representative Sequence: NM_001009955
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326956 ENST00000528930 ENST00000417664 ENST00000371320(uc001cxe.3 uc001cxf.3 uc001cxg.3)
    ENST00000371319 ENST00000533946 ENST00000357475 ENST00000426150 ENST00000444533
    ENST00000420121 ENST00000530618 ENST00000533209 ENST00000525990 ENST00000528787
    ENST00000448572
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate SSBP3 (see all 26):
    hsa-miR-30c hsa-miR-676 hsa-miR-448 hsa-miR-137 hsa-miR-25 hsa-miR-30d hsa-miR-141* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSSBP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSBP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSBP3
    Clone
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    OriGene clones in human, mouse for SSBP3 (see all 20)
    OriGene ORF clones in mouse, rat for SSBP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SSBP3 (NM_018070)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSBP3
    Sirion Biotech Customized lentivirus for stable overexpression of SSBP3 
                         Customized lentivirus expression plasmids for stable overexpression of SSBP3 
    Primer
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    OriGene qPCR primer pairs and template standards for SSBP3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSBP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSBP3

    Additional mRNA sequence: 

    AF086085.1 AF500116.1 AK001217.1 AK093975.1 AK289474.1 BC003605.1 BC004335.1 BC066365.1 
    BC127865.1 BC127866.1 

    19 DOTS entries:

    DT.100775005  DT.448803  DT.75124194  DT.100038637  DT.100808407  DT.100038640  DT.102839136  DT.97859559 
    DT.100808405  DT.40288217  DT.91766918  DT.95112787  DT.101966789  DT.121354873  DT.121355036  DT.91766909 
    DT.120998880  DT.121354943  DT.92362364 

    24/317 AceView cDNA sequences (see all 317):

    N62976 H68962 BM472021 BQ017760 AA338230 CB154553 R15809 CB147484 
    AI498861 BU838215 BI916705 AW105260 BF448725 AA242833 BU735035 AW082512 
    D80650 BF111190 BM264440 AF086085 T65318 AA243726 AI633806 CB306476 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SSBP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                      -           -                                                   
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for SSBP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSBP3 expression in normal human tissues (normalized intensities)      SSBP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTTTTTT
    SSBP3 Expression
    About this image


    SSBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 2 Thymocytes Thymus
             reticulocytes   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Brain (Nervous System)
             Adult Dopaminergic Neurons Ventral Tegmental Area

    See SSBP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSBP3

    SOURCE GeneReport for Unigene cluster: Hs.658676

    UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4
    Tissue specificity: Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood,
    bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high
    in heart, brain, kidney, and skeletal muscle

        SABiosciences Custom PCR Arrays for SSBP3
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSBP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSBP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SSBP3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssbp31 , 5 single-stranded DNA binding protein 31, 5 95.36(n)1
    100(a)1
      4 (49.90 cM)5
    724751  NM_023672.21  NP_076161.21 
     1069107015 
    chicken
    (Gallus gallus)
    Aves SSBP31 single stranded DNA binding protein 3 85.69(n)
    98.37(a)
      395250  NM_204564.1  NP_989895.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSBP36
    Uncharacterized protein
    96(a)
    1 ↔ 1
    4(104581808-104966560)
    African clawed frog
    (Xenopus laevis)
    Amphibia ssbp3-prov2 single-stranded DNA binding protein 3 81.99(n)    BC047976.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283372 Danio rerio cDNA clone MGC63791 IMAGE2644717, complete more 77.69(n)    BC056827.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ssdp1 Sequence-specific single-stranded DNA-binding protein 57.45(n)
    62.96(a)
      42177  NM_142431.1  NP_650688.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sam-106
    Protein SAM-10, isoform a
    18(a)
    1 → many
    II(13322013-13330825)


    ENSEMBL Gene Tree for SSBP3 (if available)
    TreeFam Gene Tree for SSBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSBP3 gene
    SSBP22  SSBP42  
    3 SIMAP similar genes for SSBP3 using alignment to 5 protein entries:     SSBP3_HUMAN (see all proteins):
    SSBP4    SSDP4    SSBP2

    SSBP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SSBP3
    PGOHUM00000240313 PGOHUM00000233199


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3839 SNPs in SSBP3 are shown (see all 3839)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838671311,2
    --54691718(+) TGATGC/TGAGGA 3 -- ds50010--------
    rs1423018561,2
    --54691728(+) ATCTCA/GGGACC 3 -- ds50010--------
    rs746101641,2
    C--54691766(+) CCCAGA/GTCATA 3 -- ds50010--------
    rs2016226121,2
    --54691910(+) CAGGA-/GAGGAGGA 3 -- cds10--------
    rs1499425571,2
    C--54691919(+) AGGAG-/GAAGGTGT 3 -- cds10--------
    rs106255391,2
    C--54691920(+) GGAGG-/AA    
       G
    /GAA
    GTGTC
    6 -- cds11NA 2
    rs780003551,2
    C--54691921(+) GGAGGA/GTGTCC 3 -- ds50010--------
    rs770647771,2
    C--54691922(+) GAGGGA/TGTCCT 3 -- ds50010--------
    rs115516971,2
    --54692031(+) TGCTGG/TGTTCT 3 -- ds50010--------
    rs740732421,2
    C,F--54692053(+) GTGCCG/ACTGCT 3 -- ds50011Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SSBP3 (54691105 - 54879152 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SSBP3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748308CNV Deletion23290073
    nsv509291CNV Insertion20534489
    nsv461550CNV Loss19166990
    nsv470713CNV Loss18288195
    nsv829893CNV Loss17160897
    nsv461561CNV Gain19166990
    nsv822631CNV Gain20364138
    nsv870514CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607390    OMIM disorders: --

    20 diseases for SSBP3:    About MalaCards
    thyroid lymphoma    invasive aspergillosis    progressive multifocal leukoencephalopathy    aspergillosis
    xeroderma pigmentosum    lissencephaly    herpes simplex    cytomegalovirus infection
    pancreatic ductal adenocarcinoma    retinoblastoma    hepatitis b    acute leukemia
    hepatitis    melanoma    thyroiditis    adenocarcinoma
    pancreatitis    lung cancer    leukemia    breast cancer


    SSBP3 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for SSBP3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 52.8 8 16325378 (2), 8530102 (1), 8798680 (1), 9740790 (1) (see all 6)
    cockayne syndrome 27.6 1 16325378 (1)
    retinoblastoma 19.5 2 7592647 (1), 1828394 (1)
    herpes simplex 15.8 3 10681580 (1), 9446572 (1), 11684025 (1)
    immunodeficiency 10.7 2 8943069 (1), 16439549 (1)
    skin cancer 0 1 8530102 (1)
    genetic disorder 0 1 8530102 (1)
    tumors 0 12 2118997 (1), 11152481 (1), 18453682 (1), 8524220 (1) (see all 11)
    hepatitis b 0 2 8661125 (1), 9740790 (1)
    melanoma 0 2 8502621 (1)

    Genetic Association Database (GAD): SSBP3
    Human Genome Epidemiology (HuGE) Navigator: SSBP3 (1 document)

    Export disorders for SSBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSBP3 gene, integrated from 9 sources (see all 232):
    (articles sorted by number of sources associating them with SSBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel, evolutionarily conserved gene family with putative sequence- specific single-stranded DNA-binding activity. (PubMed id 12079286)1, 2, 3 Castro P.D.... Nagarajan L. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. (PubMed id 10524251)1, 9 Raval-Fernandes S....Rome L.H. (1999)
    6. Identification of the hypoxia-inducible factor 2a nucl ear interactome in melanoma cells reveals master proteins involved in melanoma d evelopment. (PubMed id 23275444)1 Steunou A.L....Nieto L. (2013)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. TIF1gamma controls erythroid cell fate by regulating transcription elongation. (PubMed id 20603019)1 Bai X....Zon L.I. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23648 HGNC: 15674 AceView: SSBP3 Ensembl:ENSG00000157216 euGenes: HUgn23648
    ECgene: SSBP3 H-InvDB: SSBP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSBP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SSBP3 gene:
    Search GeneIP for patents involving SSBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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