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Aliases for SSBP3 Gene

Aliases for SSBP3 Gene

  • Single Stranded DNA Binding Protein 3 2 3
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 3 4
  • SSDP1 3 4
  • SSDP 3 4
  • Single-Stranded DNA-Binding Protein 3 2
  • CSDP 3

External Ids for SSBP3 Gene

Previous GeneCards Identifiers for SSBP3 Gene

  • GC01M054521
  • GC01M053580
  • GC01M054049
  • GC01M054062
  • GC01M054404
  • GC01M054464
  • GC01M054692
  • GC01M052807

Summaries for SSBP3 Gene

GeneCards Summary for SSBP3 Gene

SSBP3 (Single Stranded DNA Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

UniProtKB/Swiss-Prot for SSBP3 Gene

  • May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Wiki entry for SSBP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP3 Gene

Genomics for SSBP3 Gene

Regulatory Elements for SSBP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSBP3 Gene

Chromosome:
1
Start:
54,225,431 bp from pter
End:
54,413,485 bp from pter
Size:
188,055 bases
Orientation:
Minus strand

Genomic View for SSBP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP3 Gene

Proteins for SSBP3 Gene

  • Protein details for SSBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWW4-SSBP3_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein 3
    Protein Accession:
    Q9BWW4
    Secondary Accessions:
    • A8K0A9
    • Q5T860
    • Q5T861
    • Q9BTM0
    • Q9BWW3

    Protein attributes for SSBP3 Gene

    Size:
    388 amino acids
    Molecular mass:
    40421 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SSBP3 Gene

Proteomics data for SSBP3 Gene at MOPED

Post-translational modifications for SSBP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SSBP3 Gene

Domains & Families for SSBP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BWW4

UniProtKB/Swiss-Prot:

SSBP3_HUMAN :
  • Contains 1 LisH domain.
Domain:
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with SSBP3: view

No data available for Gene Families for SSBP3 Gene

Function for SSBP3 Gene

Molecular function for SSBP3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region.

Gene Ontology (GO) - Molecular Function for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SSBP3: view
genes like me logo Genes that share phenotypes with SSBP3: view

Animal Model Products

miRNA for SSBP3 Gene

miRTarBase miRNAs that target SSBP3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSBP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SSBP3 Gene

Localization for SSBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSBP3 Gene COMPARTMENTS Subcellular localization image for SSBP3 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with SSBP3: view

Pathways & Interactions for SSBP3 Gene

SuperPathways for SSBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006461 protein complex assembly IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0021501 prechordal plate formation IEA --
genes like me logo Genes that share ontologies with SSBP3: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP3 Gene

Drugs & Compounds for SSBP3 Gene

(13) Drugs for SSBP3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Zinc Approved Pharma 1404
Biotin Approved Nutra 34
Thymine Experimental Pharma 0

(5) Additional Compounds for SSBP3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BamHi
Cytosine
  • 4-Amino-2(1H)-pyrimidinone
  • 4-Amino-2-hydroxypyrimidine
  • 4-Amino-2-oxo-1,2-dihydropyrimidine
  • 4-Aminouracil
  • Cytosine
71-30-7
Oligonucleotide
Polyacrylamide
retinoic acid
302-79-4
genes like me logo Genes that share compounds with SSBP3: view

Transcripts for SSBP3 Gene

Unigene Clusters for SSBP3 Gene

Single stranded DNA binding protein 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSBP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:

Relevant External Links for SSBP3 Gene

GeneLoc Exon Structure for
SSBP3
ECgene alternative splicing isoforms for
SSBP3

Expression for SSBP3 Gene

mRNA expression in normal human tissues for SSBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP3 Gene

This gene is overexpressed in NK cells (13.2), Uterus (10.9), Tlymphocyte (10.3), Ovary (10.1), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSBP3 Gene



SOURCE GeneReport for Unigene cluster for SSBP3 Gene Hs.658676

mRNA Expression by UniProt/SwissProt for SSBP3 Gene

Q9BWW4-SSBP3_HUMAN
Tissue specificity: Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high in heart, brain, kidney, and skeletal muscle
genes like me logo Genes that share expression patterns with SSBP3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SSBP3 Gene

Orthologs for SSBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSBP3 35
  • 96.39 (n)
  • 99.74 (a)
SSBP3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSBP3 35
  • 94.57 (n)
  • 97.47 (a)
SSBP3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp3 35
  • 95.36 (n)
  • 100 (a)
Ssbp3 16
Ssbp3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSBP3 35
  • 94.85 (n)
  • 93.5 (a)
SSBP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssbp3 35
  • 94.83 (n)
  • 99.45 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSBP3 35
  • 85.69 (n)
  • 98.37 (a)
SSBP3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSBP3 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75859 35
ssbp3 35
  • 80.68 (n)
  • 95.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia ssbp3-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28337 35
ssbp3a 35
  • 76.75 (n)
  • 86.47 (a)
ssbp3a 36
  • 85 (a)
OneToMany
ssbp3b 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010909 35
  • 62.99 (n)
  • 69.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ssdp 35
  • 55.92 (n)
  • 60.61 (a)
Ssdp 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sam-10 36
  • 22 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4608 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 36
  • 60 (a)
OneToMany
Species with no ortholog for SSBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP3 Gene

ENSEMBL:
Gene Tree for SSBP3 (if available)
TreeFam:
Gene Tree for SSBP3 (if available)

Paralogs for SSBP3 Gene

Paralogs for SSBP3 Gene

(3) SIMAP similar genes for SSBP3 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SSBP3 Gene

genes like me logo Genes that share paralogs with SSBP3: view

Variants for SSBP3 Gene

Sequence variations from dbSNP and Humsavar for SSBP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs43902 -- 54,252,053(+) TAGCT(A/C/T)TAACT intron-variant
rs104136 -- 54,253,492(+) TGGCC(C/T)ACAAA intron-variant
rs213479 -- 54,396,154(-) AGTGC(A/C)ATGGC intron-variant
rs213480 -- 54,396,141(-) GATCT(C/T)GGCTC intron-variant
rs213481 -- 54,395,867(-) TAGCA(A/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP3 Gene

Variant ID Type Subtype PubMed ID
nsv829893 CNV Loss 17160897
nsv509291 CNV Insertion 20534489
nsv461550 CNV Loss 19166990
nsv470713 CNV Loss 18288195
esv2748308 CNV Deletion 23290073
nsv870514 CNV Gain 21882294
nsv822631 CNV Gain 20364138
nsv461561 CNV Gain 19166990

Variation tolerance for SSBP3 Gene

Residual Variation Intolerance Score: 35.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSBP3 Gene

HapMap Linkage Disequilibrium report
SSBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP3 Gene

Disorders for SSBP3 Gene

Relevant External Links for SSBP3

Genetic Association Database (GAD)
SSBP3
Human Genome Epidemiology (HuGE) Navigator
SSBP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSBP3
genes like me logo Genes that share disorders with SSBP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP3 Gene

Publications for SSBP3 Gene

  1. Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia. (PMID: 20306249) Engel M.E. … Hiebert S.W. (Cancer Treat. Res. 2010) 23 67
  2. The conjugative DNA translocase TrwB is a structure-specific DNA-binding protein. (PMID: 20375020) Matilla I. … Cabezon E. (J. Biol. Chem. 2010) 23 67
  3. Identification of sequence-specific DNA-binding proteins by southwestern blotting. (PMID: 19378166) LabbAc S. … SAcguin C. (Methods Mol. Biol. 2009) 23 67
  4. Dissecting the roles of MuB in Mu transposition: ATP regulation of DNA binding is not essential for target delivery. (PMID: 18719126) Schweidenback C.T. … Baker T.A. (Proc. Natl. Acad. Sci. U.S.A. 2008) 23 67
  5. Allosteric signaling in the biotin repressor occurs via local folding coupled to global dampening of protein dynamics. (PMID: 18586268) Laine O. … Beckett D. (J. Mol. Biol. 2008) 23 67

Products for SSBP3 Gene

Sources for SSBP3 Gene

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