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SSBP3 Gene

protein-coding   GIFtS: 53
GCID: GC01M054692

Single Stranded DNA Binding Protein 3

(Previous name: single-stranded DNA-binding protein 3)
  See SSBP3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Single Stranded DNA Binding Protein 31 2
Single-Stranded DNA-Binding Protein 31 2
Sequence-Specific Single-Stranded-DNA-Binding Protein2 3
SSDP2 3
SSDP12 3
CSDP2

External Ids:    HGNC: 156741   Entrez Gene: 236482   Ensembl: ENSG000001572167   OMIM: 6073905   UniProtKB: Q9BWW43   

Export aliases for SSBP3 gene to outside databases

Previous GC identifers: GC01M054521 GC01M053580 GC01M054049 GC01M054062 GC01M054404 GC01M054464 GC01M052807


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SSBP3 Gene:
SSBP3 (single stranded DNA binding protein 3) is a protein-coding gene. Diseases associated with SSBP3 include thyroid lymphoma. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP2.

UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4
Function: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the
single-stranded polypyrimidine sequences in the promoter region (By similarity)

Gene Wiki entry for SSBP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSBP3 gene promoter:
         E2F-1   E2F-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSBP3 promoter sequence
   Search Chromatin IP Primers for SSBP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.3   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.3

SSBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSBP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M054692:  view genomic region     (about GC identifiers)

Start:
54,691,105 bp from pter      End:
54,879,152 bp from pter
Size:
188,048 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4 (See protein sequence)
Recommended Name: Single-stranded DNA-binding protein 3  
Size: 388 amino acids; 40421 Da
Secondary accessions: A8K0A9 Q5T860 Q5T861 Q9BTM0 Q9BWW3
Alternative splicing: 3 isoforms:  Q9BWW4-1   Q9BWW4-2   Q9BWW4-3   

Explore the universe of human proteins at neXtProt for SSBP3: NX_Q9BWW4

Explore proteomics data for SSBP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys19
  • Modification sites at PhosphoSitePlus

  • See SSBP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001009955.1  NP_060540.2  NP_663768.1  

    ENSEMBL proteins: 
     ENSP00000414361   ENSP00000360371   ENSP00000360370   ENSP00000350067   ENSP00000405880  
     ENSP00000431654  

    SSBP3 Human Recombinant Protein Products:

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    Novus Biologicals SSBP3 Proteins
    Novus Biologicals SSBP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SSBP3

     
    Search eBioscience for Proteins for SSBP3 

     
    antibodies-online proteins for SSBP3 (8 products) 

     
    antibodies-online peptides for SSBP3

    SSBP3 Antibody Products:

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    Abcam antibodies for SSBP3 (Q9BWW4, Q5T860)
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    antibodies-online antibodies for SSBP3 (18 products) 

    SSBP3 Assay Products:

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    Cloud-Clone Corp. ELISAs for SSBP3
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    antibodies-online kits for SSBP3 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008116 SSDP_DNA-bd
     IPR006594 LisH_dimerisation

    Graphical View of Domain Structure for InterPro Entry Q9BWW4

    ProtoNet protein and cluster: Q9BWW4

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB007591 Single-stranded DNA-binding protein


    UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4
    Similarity: Contains 1 LisH domain


    Find genes that share domains with SSBP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSBP3_HUMAN, Q9BWW4
    Function: May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the
    single-stranded polypyrimidine sequences in the promoter region (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SSBP3           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ssbp3):
     craniofacial  embryogenesis  growth/size/body  mortality/aging  nervous system 
     normal  skeleton 

    Find genes that share phenotypes with SSBP3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SSBP3

    miRNA
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    Block miRNA regulation of human, mouse, rat SSBP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SSBP3 (see all 26):
    hsa-miR-30c hsa-miR-676 hsa-miR-448 hsa-miR-137 hsa-miR-25 hsa-miR-30d hsa-miR-141* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSSBP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SSBP3
    Predesigned siRNA for gene silencing in human, mouse, rat SSBP3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): SSBP3 (NM_018070)
    Sino Biological Human cDNA Clone for SSBP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSBP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSBP3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SSBP3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSBP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSBP3_HUMAN, Q9BWW4: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0043234protein complex IEA--

    Find genes that share ontologies with SSBP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSBP3
    Interactions:

        Search GeneGlobe Interaction Network for SSBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSBP3 (Q9BWW43 ENSP000003603714) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    TAL1P175423, ENSP000002943394I2D: score=2 STRING: ENSP00000294339
    ASB3Q9Y5753I2D: score=1 
    GPR75-ASB3Q9Y5753I2D: score=1 
    HCLS1P143173, ENSP000003201764I2D: score=1 STRING: ENSP00000320176
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006461protein complex assembly IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0021501prechordal plate formation IEA--
    GO:0021547midbrain-hindbrain boundary initiation IEA--

    Find genes that share ontologies with SSBP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSBP3

    Selected Novoseek inferred chemical compound relationships for SSBP3 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 42.5 12 12592413 (2), 2118997 (1), 9431812 (1), 14527952 (1) (see all 10)
    oligonucleotide 41.2 3 7999067 (1), 11713803 (1), 7964651 (1)
    leucine 26 3 1748630 (1), 16580748 (1), 11295448 (1)
    cytosine 14.5 1 16608167 (1)
    biotin 14.3 1 18586268 (1)
    bamhi 13 1 15196020 (1)
    polyacrylamide 2.47 1 18265085 (1)
    thymine 1.69 1 15134443 (1)
    atp 0 2 18719126 (1), 9882364 (1)
    threonine 0 1 2055486 (1)



    Find genes that share compounds with SSBP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSBP3 gene (3 alternative transcripts): 
    NM_001009955.3  NM_018070.4  NM_145716.3  

    Unigene Cluster for SSBP3:

    Single stranded DNA binding protein 3
    Hs.658676  [show with all ESTs]
    Unigene Representative Sequence: NM_001009955
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326956 ENST00000528930 ENST00000417664 ENST00000371320(uc001cxe.3 uc001cxf.3 uc001cxg.3)
    ENST00000371319 ENST00000533946 ENST00000357475 ENST00000426150 ENST00000444533
    ENST00000420121 ENST00000530618 ENST00000533209 ENST00000525990 ENST00000528787
    ENST00000448572
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SSBP3 (see all 26):
    hsa-miR-30c hsa-miR-676 hsa-miR-448 hsa-miR-137 hsa-miR-25 hsa-miR-30d hsa-miR-141* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidSSBP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSBP3
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    Primer
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    OriGene qPCR primer pairs and template standards for SSBP3
    OriGene qSTAR qPCR primer pairs in human, mouse for SSBP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSBP3
      QuantiTect SYBR Green Assays in human, mouse, rat SSBP3
      QuantiFast Probe-based Assays in human, mouse, rat SSBP3

    Additional mRNA sequence: 

    AF086085.1 AF500116.1 AK001217.1 AK093975.1 AK289474.1 BC003605.1 BC004335.1 BC066365.1 
    BC127865.1 BC127866.1 

    19 DOTS entries:

    DT.100775005  DT.448803  DT.75124194  DT.100038637  DT.100808407  DT.100038640  DT.102839136  DT.97859559 
    DT.100808405  DT.40288217  DT.91766918  DT.95112787  DT.101966789  DT.121354873  DT.121355036  DT.91766909 
    DT.120998880  DT.121354943  DT.92362364 

    Selected AceView cDNA sequences (see all 317):

    AW135318 D61242 AI368944 AA242833 AI148912 AI565975 CB147484 BG656522 
    BM976799 BC004335 BF448725 BU838215 AI248755 BM472021 AI203041 BQ017760 
    AI633806 CB306476 BM703710 R15809 AF086085 H68962 CB215418 T65318 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SSBP3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                      -           -                                                   
    SP2:                                                                                                      


    ECgene alternative splicing isoforms for SSBP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSBP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACACTTTTTT
    SSBP3 Expression
    About this image


    SSBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Neurons
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Adult Dopaminergic Neurons Ventral Tegmental Area
    SSBP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSBP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658676

    UniProtKB/Swiss-Prot: SSBP3_HUMAN, Q9BWW4
    Tissue specificity: Highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood,
    bone marrow, thymus, and fetal liver, with highest expression in thymus and fetal liver. Expression is also high
    in heart, brain, kidney, and skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSBP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SSBP3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssbp31 , 5 single-stranded DNA binding protein 31, 5 95.36(n)1
    100(a)1
      4 (49.90 cM)5
    724751  NM_023672.21  NP_076161.21 
     1069107015 
    chicken
    (Gallus gallus)
    Aves SSBP31 single stranded DNA binding protein 3 85.69(n)
    98.37(a)
      395250  NM_204564.1  NP_989895.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSBP36
    single stranded DNA binding protein 3
    95(a)
    1 ↔ 1
    4(104581808-104966560)
    African clawed frog
    (Xenopus laevis)
    Amphibia ssbp3-prov2 single-stranded DNA binding protein 3 81.99(n)    BC047976.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.283372 Danio rerio cDNA clone MGC63791 IMAGE2644717, complete more 77.69(n)    BC056827.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ssdp1 Sequence-specific single-stranded DNA-binding protein 55.92(n)
    60.61(a)
      42177  NM_142431.1  NP_650688.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sam-106
    Protein SAM-10, isoform a
    22(a)
    1 → many
    II(13322013-13330825) WBGene00012990


    ENSEMBL Gene Tree for SSBP3 (if available)
    TreeFam Gene Tree for SSBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSBP3 gene
    SSBP22  SSBP42  
    3 SIMAP similar genes for SSBP3 using alignment to 5 protein entries:     SSBP3_HUMAN (see all proteins):
    SSBP4    SSDP4    SSBP2

    Find genes that share paralogs with SSBP3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SSBP3
    PGOHUM00000240313 PGOHUM00000233199


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSBP3 (see all 3839)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838671311,2
    --54691718(+) TGATGC/TGAGGA 3 -- ds50010--------
    rs1423018561,2
    --54691728(+) ATCTCA/GGGACC 3 -- ds50010--------
    rs746101641,2
    C--54691766(+) CCCAGA/GTCATA 3 -- ds50010--------
    rs2016226121,2
    --54691910(+) CAGGA-/GAGGAGGA 3 -- cds10--------
    rs1499425571,2
    C--54691919(+) AGGAG-/GAAGGTGT 3 -- cds10--------
    rs106255391,2
    C--54691920(+) GGAGG-/AA    
       G
    /GAA
    GTGTC
    6 -- cds11NA 2
    rs780003551,2
    C--54691921(+) GGAGGA/GTGTCC 3 -- ds50010--------
    rs770647771,2
    C--54691922(+) GAGGGA/TGTCCT 3 -- ds50010--------
    rs115516971,2
    --54692031(+) TGCTGG/TGTTCT 3 -- ds50010--------
    rs740732421,2
    C,F--54692053(+) GTGCCG/ACTGCT 3 -- ds50011Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SSBP3 (54691105 - 54879152 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SSBP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748308CNV Deletion23290073
    nsv509291CNV Insertion20534489
    nsv461550CNV Loss19166990
    nsv470713CNV Loss18288195
    nsv829893CNV Loss17160897
    nsv461561CNV Gain19166990
    nsv822631CNV Gain20364138
    nsv870514CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607390    OMIM disorders: --

    1 disease for SSBP3:    
    About MalaCards
    thyroid lymphoma


    Find genes that share disorders with SSBP3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SSBP3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 52.8 8 16325378 (2), 8530102 (1), 8798680 (1), 9740790 (1) (see all 6)
    cockayne syndrome 27.6 1 16325378 (1)
    retinoblastoma 19.5 2 7592647 (1), 1828394 (1)
    herpes simplex 15.8 3 10681580 (1), 9446572 (1), 11684025 (1)
    immunodeficiency 10.7 2 8943069 (1), 16439549 (1)
    skin cancer 0 1 8530102 (1)
    genetic disorder 0 1 8530102 (1)
    tumors 0 12 2118997 (1), 11152481 (1), 18453682 (1), 8524220 (1) (see all 11)
    hepatitis b 0 2 8661125 (1), 9740790 (1)
    melanoma 0 2 8502621 (1)

    Genetic Association Database (GAD): SSBP3
    Human Genome Epidemiology (HuGE) Navigator: SSBP3 (1 document)

    Export disorders for SSBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSBP3 gene, integrated from 10 sources (see all 233):
    (articles sorted by number of sources associating them with SSBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel, evolutionarily conserved gene family with putative sequence- specific single-stranded DNA-binding activity. (PubMed id 12079286)1, 2, 3 Castro P.D.... Nagarajan L. (Genomics 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus. (PubMed id 10524251)1, 9 Raval-Fernandes S....Rome L.H. (Gene 1999)
    6. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23648 HGNC: 15674 AceView: SSBP3 Ensembl:ENSG00000157216 euGenes: HUgn23648
    ECgene: SSBP3 H-InvDB: SSBP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SSBP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSBP3 gene:
    Search GeneIP for patents involving SSBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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