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Aliases for SSBP2 Gene

Aliases for SSBP2 Gene

  • Single Stranded DNA Binding Protein 2 2 3 5
  • Sequence-Specific Single-Stranded-DNA-Binding Protein 2 3 4
  • Single-Stranded DNA-Binding Protein 2 2 3
  • Single-Stranded DNA Binding Protein 2 2
  • SOSS-B2 3
  • HSPC116 3
  • SSDP2 4

External Ids for SSBP2 Gene

Previous GeneCards Identifiers for SSBP2 Gene

  • GC05M079501
  • GC05M080954
  • GC05M080754
  • GC05M080799
  • GC05M080751
  • GC05M075924

Summaries for SSBP2 Gene

Entrez Gene Summary for SSBP2 Gene

  • This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]

GeneCards Summary for SSBP2 Gene

SSBP2 (Single Stranded DNA Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include single-stranded DNA binding. An important paralog of this gene is SSBP3.

Gene Wiki entry for SSBP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP2 Gene

Genomics for SSBP2 Gene

Regulatory Elements for SSBP2 Gene

Enhancers for SSBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F081849 1 FANTOM5 ENCODE 5.5 -100.2 -100208 4.8 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 CBX5 ZNF207 ZNF263 ATP6AP1L SSBP2 PPIAP11 ENSG00000249483 SEM1P1
GH05F081419 0.8 Ensembl ENCODE 5.2 +330.1 330149 4.9 PKNOX1 FEZF1 BRCA1 YY1 ZNF302 FOS YY2 TSHZ1 ZNF518A MAFF ACOT12 ENSG00000248794 SSBP2 GC05M081414 GC05P081482
GH05F081401 0.9 ENCODE 4.9 +349.3 349340 0.9 PKNOX1 SSBP2 ACOT12 GC05M081414
GH05F081552 0.8 Ensembl ENCODE 4.8 +198.2 198162 1.4 JUN PRDM1 SSBP2 GC05M081517
GH05F081411 0.3 FANTOM5 4.7 +339.9 339949 0.0 SSBP2 GC05M081414 ACOT12
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SSBP2 on UCSC Golden Path with GeneCards custom track

Promoters for SSBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SSBP2 Gene

81,413,021 bp from pter
81,751,797 bp from pter
338,777 bases
Minus strand

Genomic View for SSBP2 Gene

Genes around SSBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP2 Gene

Proteins for SSBP2 Gene

  • Protein details for SSBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Single-stranded DNA-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R5W1
    • B7Z1J2
    • B7Z2L9
    • B7Z665
    • D6RH18
    • E9PB74
    • E9PDA8
    • Q8N2Q2
    • Q9BWW6
    • Q9Y4T7

    Protein attributes for SSBP2 Gene

    361 amino acids
    Molecular mass:
    37828 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SSBP2 Gene


neXtProt entry for SSBP2 Gene

Post-translational modifications for SSBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SSBP2 Gene

Domains & Families for SSBP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LisH domain.
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with SSBP2: view

No data available for Gene Families for SSBP2 Gene

Function for SSBP2 Gene

Gene Ontology (GO) - Molecular Function for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003697 single-stranded DNA binding IEA,NAS 12079286
genes like me logo Genes that share ontologies with SSBP2: view
genes like me logo Genes that share phenotypes with SSBP2: view

Animal Models for SSBP2 Gene

MGI Knock Outs for SSBP2:

Animal Model Products

miRNA for SSBP2 Gene

miRTarBase miRNAs that target SSBP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSBP2 Gene

Localization for SSBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP2 Gene

Subcellular locations from

Jensen Localization Image for SSBP2 Gene COMPARTMENTS Subcellular localization image for SSBP2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with SSBP2: view

Pathways & Interactions for SSBP2 Gene

SuperPathways for SSBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SSBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 12079286
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with SSBP2: view

No data available for Pathways by source and SIGNOR curated interactions for SSBP2 Gene

Transcripts for SSBP2 Gene

Unigene Clusters for SSBP2 Gene

Single-stranded DNA binding protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP2 Gene

No ASD Table

Relevant External Links for SSBP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SSBP2 Gene

mRNA expression in normal human tissues for SSBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP2 Gene

This gene is overexpressed in CD4 Tcells (15.2), Fetal ovary (14.0), Blymphocyte (8.1), CD8 Tcells (7.5), and Fetal heart (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSBP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SSBP2 Gene:


SOURCE GeneReport for Unigene cluster for SSBP2 Gene:


mRNA Expression by UniProt/SwissProt for SSBP2 Gene:

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SSBP2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SSBP2 Gene

Orthologs for SSBP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia SSBP2 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
-- 35
  • 95 (a)
(Canis familiaris)
Mammalia SSBP2 34 35
  • 97.65 (n)
(Bos Taurus)
Mammalia SSBP2 34 35
  • 97.14 (n)
(Mus musculus)
Mammalia Ssbp2 34 16 35
  • 95.66 (n)
(Pan troglodytes)
Mammalia SSBP2 34 35
  • 95.07 (n)
(Rattus norvegicus)
Mammalia Ssbp2 34
  • 92.18 (n)
(Gallus gallus)
Aves SSBP2 34 35
  • 91.85 (n)
(Anolis carolinensis)
Reptilia SSBP2 35
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp2 34
  • 84.77 (n)
African clawed frog
(Xenopus laevis)
Amphibia ssbp2-prov 34
(Danio rerio)
Actinopterygii SSBP2 (2 of 2) 35
  • 83 (a)
SSBP2 (1 of 2) 35
  • 81 (a)
LOC798086 34
  • 74.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7187 36
  • 91 (a)
Ssdp 35
  • 46 (a)
(Caenorhabditis elegans)
Secernentea sam-10 35
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.102 35
  • 55 (a)
Species where no ortholog for SSBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSBP2 Gene

Gene Tree for SSBP2 (if available)
Gene Tree for SSBP2 (if available)

Paralogs for SSBP2 Gene

Paralogs for SSBP2 Gene

(3) SIMAP similar genes for SSBP2 Gene using alignment to 4 proteins: Pseudogenes for SSBP2 Gene

genes like me logo Genes that share paralogs with SSBP2: view

Variants for SSBP2 Gene

Sequence variations from dbSNP and Humsavar for SSBP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs193920757 Uncertain significance 81,448,794(-) GAATT(A/T)TGTAG reference, missense
rs10035291 -- 81,500,549(+) tccac(C/T)tcctg intron-variant
rs10035410 -- 81,706,855(+) TCCTC(C/T)AGGGA intron-variant
rs10035917 -- 81,726,675(+) TATCC(C/T)ACTTT intron-variant
rs10036232 -- 81,721,963(+) CTGAT(A/C)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP2 Gene

Variant ID Type Subtype PubMed ID
dgv1109e214 CNV loss 21293372
dgv3107n106 CNV deletion 24896259
esv1711772 CNV deletion 17803354
esv2034602 CNV deletion 18987734
esv2125406 CNV deletion 18987734
esv2524327 CNV deletion 19546169
esv2613325 CNV deletion 19546169
esv2668722 CNV deletion 23128226
esv2730382 CNV deletion 23290073
esv2730383 CNV deletion 23290073
esv2730385 CNV deletion 23290073
esv2730386 CNV deletion 23290073
esv2763467 CNV loss 21179565
esv3134 CNV loss 18987735
esv3566174 CNV deletion 23714750
esv3566175 CNV deletion 23714750
esv3605594 CNV gain 21293372
esv3605595 CNV gain 21293372
esv3605597 CNV gain 21293372
esv3605599 CNV gain 21293372
esv3605601 CNV loss 21293372
esv3605602 CNV gain 21293372
esv3605603 CNV loss 21293372
esv3605604 CNV loss 21293372
esv3890665 CNV loss 25118596
esv4616 CNV loss 18987735
esv993941 CNV deletion 20482838
nsv1028322 CNV gain 25217958
nsv1073900 CNV deletion 25765185
nsv1074849 CNV deletion 25765185
nsv1114697 CNV deletion 24896259
nsv1139842 CNV duplication 24896259
nsv1144112 CNV deletion 24896259
nsv1146271 CNV duplication 26484159
nsv1146766 CNV deletion 26484159
nsv1149956 CNV deletion 26484159
nsv327664 CNV deletion 16902084
nsv462221 CNV loss 19166990
nsv462222 CNV gain 19166990
nsv471018 CNV gain 18288195
nsv4900 CNV deletion 18451855
nsv519589 CNV gain+loss 19592680
nsv525225 CNV loss 19592680
nsv525437 CNV loss 19592680
nsv527374 CNV loss 19592680
nsv598751 CNV loss 21841781
nsv598752 CNV gain 21841781
nsv598753 CNV gain 21841781
nsv830361 CNV loss 17160897
nsv830362 CNV gain 17160897
nsv950097 CNV deletion 24416366
nsv956443 CNV deletion 24416366
nsv956479 CNV deletion 24416366

Variation tolerance for SSBP2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP2 Gene

Disorders for SSBP2 Gene

Relevant External Links for SSBP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SSBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP2 Gene

Publications for SSBP2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. SSBP2 variants are associated with survival in glioblastoma patients. (PMID: 22472174) Xiao Y. … Wrensch M.R. (Clin. Cancer Res. 2012) 3 46 64
  3. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. (PMID: 21079607) Wang K. … Hakonarson H. (Mol. Psychiatry 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. (PMID: 17311003) Fleisig H.B. … Nagarajan L. (Oncogene 2007) 3 22 64

Products for SSBP2 Gene

Sources for SSBP2 Gene

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