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Aliases for SSBP1 Gene

Aliases for SSBP1 Gene

  • Single Stranded DNA Binding Protein 1 2 3
  • Single-Stranded DNA Binding Protein 1, Mitochondrial 2 3 5
  • PWP1-Interacting Protein 17 3 4
  • Mt-SSB 3 4
  • MtSSB 3 4
  • SSBP 3 4
  • Single-Stranded DNA Binding Protein 1 2
  • Single-Stranded DNA-Binding Protein 2
  • SOSS-B1 3

External Ids for SSBP1 Gene

Previous GeneCards Identifiers for SSBP1 Gene

  • GC07P139708
  • GC07P140768
  • GC07P140845
  • GC07P140891
  • GC07P141084
  • GC07P141440
  • GC07P135734
  • GC07P141442
  • GC07P141445
  • GC07P142608
  • GC07P142902

Summaries for SSBP1 Gene

Entrez Gene Summary for SSBP1 Gene

  • SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

GeneCards Summary for SSBP1 Gene

SSBP1 (Single Stranded DNA Binding Protein 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Transcriptional activation of mitochondrial biogenesis. GO annotations related to this gene include poly(A) RNA binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot for SSBP1 Gene

  • This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.

Gene Wiki entry for SSBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP1 Gene

Genomics for SSBP1 Gene

Regulatory Elements for SSBP1 Gene

Promoters for SSBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SSBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SSBP1 Gene

Chromosome:
7
Start:
141,738,321 bp from pter
End:
141,787,922 bp from pter
Size:
49,602 bases
Orientation:
Plus strand

Genomic View for SSBP1 Gene

Genes around SSBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP1 Gene

Proteins for SSBP1 Gene

  • Protein details for SSBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04837-SSBP_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein, mitochondrial
    Protein Accession:
    Q04837

    Protein attributes for SSBP1 Gene

    Size:
    148 amino acids
    Molecular mass:
    17260 Da
    Quaternary structure:
    • Homotetramer (By similarity). Interacts with MPG/AAG, through inhibition of its glycosylase activity it potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA.

    Three dimensional structures from OCA and Proteopedia for SSBP1 Gene

neXtProt entry for SSBP1 Gene

Proteomics data for SSBP1 Gene at MOPED

Post-translational modifications for SSBP1 Gene

  • Ubiquitination at Lys 51 and Lys 122
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SSBP1 Gene

Domains & Families for SSBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q04837

UniProtKB/Swiss-Prot:

SSBP_HUMAN :
  • Contains 1 SSB domain.
Domain:
  • Contains 1 SSB domain.
genes like me logo Genes that share domains with SSBP1: view

No data available for Gene Families for SSBP1 Gene

Function for SSBP1 Gene

Molecular function for SSBP1 Gene

UniProtKB/Swiss-Prot Function:
This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA.

Gene Ontology (GO) - Molecular Function for SSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IEA --
genes like me logo Genes that share ontologies with SSBP1: view
genes like me logo Genes that share phenotypes with SSBP1: view

Animal Models for SSBP1 Gene

MGI Knock Outs for SSBP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SSBP1 Gene

Localization for SSBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP1 Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSBP1 Gene COMPARTMENTS Subcellular localization image for SSBP1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for SSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SSBP1: view

Pathways & Interactions for SSBP1 Gene

genes like me logo Genes that share pathways with SSBP1: view

Gene Ontology (GO) - Biological Process for SSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with SSBP1: view

No data available for SIGNOR curated interactions for SSBP1 Gene

Drugs & Compounds for SSBP1 Gene

(1) Drugs for SSBP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SSBP1: view

Transcripts for SSBP1 Gene

Unigene Clusters for SSBP1 Gene

Single-stranded DNA binding protein 1, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - -

Relevant External Links for SSBP1 Gene

GeneLoc Exon Structure for
SSBP1
ECgene alternative splicing isoforms for
SSBP1

Expression for SSBP1 Gene

mRNA expression in normal human tissues for SSBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SSBP1 Gene

This gene is overexpressed in Nasal epithelium (7.4) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSBP1 Gene



SOURCE GeneReport for Unigene cluster for SSBP1 Gene Hs.490394

genes like me logo Genes that share expression patterns with SSBP1: view

Protein tissue co-expression partners for SSBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSBP1 Gene

Orthologs for SSBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SSBP1 35
  • 89.12 (n)
  • 89.8 (a)
SSBP1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855532 35
  • 89.8 (n)
  • 90.48 (a)
SSBP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp1 35
  • 90.25 (n)
  • 92.52 (a)
Ssbp1 16
Ssbp1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SSBP1 35
  • 99.55 (n)
  • 100 (a)
SSBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssbp1 35
  • 89.57 (n)
  • 89.12 (a)
oppossum
(Monodelphis domestica)
Mammalia SSBP1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SSBP1 35
  • 77.32 (n)
  • 81.63 (a)
SSBP1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSBP1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp1 35
  • 69.48 (n)
  • 80.28 (a)
Str.1603 35
African clawed frog
(Xenopus laevis)
Amphibia XL 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17626 35
ssbp1 35
  • 69.86 (n)
  • 72.6 (a)
ssbp1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002477 35
  • 48.06 (n)
  • 47.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta mtSSB 35
  • 47.58 (n)
  • 44.27 (a)
mtSSB 36
  • 39 (a)
OneToOne
Species with no ortholog for SSBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSBP1 Gene

ENSEMBL:
Gene Tree for SSBP1 (if available)
TreeFam:
Gene Tree for SSBP1 (if available)

Paralogs for SSBP1 Gene

Pseudogenes.org Pseudogenes for SSBP1 Gene

genes like me logo Genes that share paralogs with SSBP1: view

No data available for Paralogs for SSBP1 Gene

Variants for SSBP1 Gene

Sequence variations from dbSNP and Humsavar for SSBP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1803994 -- 141,750,430(+) TCCAA(A/G)GACAA nc-transcript-variant, utr-variant-3-prime
rs3735279 -- 141,750,211(-) CATTA(A/G)AAGGA intron-variant
rs6951586 -- 141,750,103(+) TGTTC(A/G)AAAAG intron-variant
rs11554108 -- 141,750,423(+) TATGG(C/G)TTCCA nc-transcript-variant, utr-variant-3-prime
rs10485835 -- 141,747,018(+) AAGAA(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP1 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Variation tolerance for SSBP1 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSBP1 Gene

HapMap Linkage Disequilibrium report
SSBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSBP1 Gene

Disorders for SSBP1 Gene

Relevant External Links for SSBP1

Genetic Association Database (GAD)
SSBP1
Human Genome Epidemiology (HuGE) Navigator
SSBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSBP1

No disorders were found for SSBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SSBP1 Gene

Publications for SSBP1 Gene

  1. Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. (PMID: 7789991) Tiranti V. … Zeviani M. (Genomics 1995) 2 3 23 67
  2. CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein. (PMID: 19786724) Radulovic M. … Yu V.P. (Mol. Cell Proteomics 2010) 3 23
  3. Epstein-Barr virus immediate-early protein Zta co-opts mitochondrial single-stranded DNA binding protein to promote viral and inhibit mitochondrial DNA replication. (PMID: 18305033) Wiedmer A. … Lieberman P.M. (J. Virol. 2008) 3 23
  4. PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid. (PMID: 16428295) Cheng X. … Kang D. (J. Biochem. 2005) 3 23
  5. Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. (PMID: 11964388) Takamatsu C. … Kang D. (EMBO Rep. 2002) 3 23

Products for SSBP1 Gene

Sources for SSBP1 Gene

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