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SSBP1 Gene

protein-coding   GIFtS: 62
GCID: GC07P141445

Single-Stranded DNA Binding Protein 1, Mitochondrial

(Previous names: single-stranded DNA-binding protein, single-stranded DNA...)
  See SSBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Single-Stranded DNA Binding Protein 1, Mitochondrial1 2     Single-Stranded DNA-Binding Protein1
SSBP2 3 5     SOSS-B12
Mt-SSB2 3     mtSSB2
PWP1-Interacting Protein 172 3     Single-Stranded DNA-Binding Protein, Mitochondrial2
Single-Stranded DNA Binding Protein 11     MtSSB3

External Ids:    HGNC: 113171   Entrez Gene: 67422   Ensembl: ENSG000001060287   OMIM: 6004395   UniProtKB: Q048373   

Export aliases for SSBP1 gene to outside databases

Previous GC identifers: GC07P139708 GC07P140768 GC07P140845 GC07P140891 GC07P141084 GC07P141440 GC07P135734 GC07P141442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSBP1 Gene:
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 (PubMed 7789991)). It is
also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability
(Huang et al., 2009) (PubMed 19683501).(supplied by OMIM, Feb 2010)

GeneCards Summary for SSBP1 Gene:
SSBP1 (single-stranded DNA binding protein 1, mitochondrial) is a protein-coding gene. Diseases associated with SSBP1 include herpes simplex. GO annotations related to this gene include chromatin binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot: SSBP_HUMAN, Q04837
Function: This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA
replication. Associates with mitochondrial DNA

Gene Wiki entry for SSBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSBP1 gene promoter:
         Pbx1a   HTF   GCNF   LCR-F1   Roaz   AREB6   GCNF-1   FOXJ2 (long isoform)   FOXJ2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSBP1 promoter sequence
   Search Chromatin IP Primers for SSBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

SSBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSBP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P141445:  view genomic region     (about GC identifiers)

Start:
141,438,121 bp from pter      End:
141,487,722 bp from pter
Size:
49,602 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,CRA_TCAG 140,775,895-140,787,976      Chr7+,NW_003315922 110,976-118,190     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SSBP_HUMAN, Q04837 (See protein sequence)
Recommended Name: Single-stranded DNA-binding protein, mitochondrial precursor  
Size: 148 amino acids; 17260 Da
Subunit: Homotetramer (By similarity)
3 PDB 3D structures from and Proteopedia for SSBP1:
1S3O (3D)        2DUD (3D)        3ULL (3D)    

Explore the universe of human proteins at neXtProt for SSBP1: NX_Q04837

Explore proteomics data for SSBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys51, Lys81, Lys122
  • Modification sites at PhosphoSitePlus

  • See SSBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001243439.1  NP_001243440.1  NP_001243441.1  NP_001243442.1  NP_003134.1  

    ENSEMBL proteins: 
     ENSP00000265304   ENSP00000419541   ENSP00000418068   ENSP00000420485   ENSP00000419579  
     ENSP00000419388   ENSP00000418181   ENSP00000419665  
    Reactome Protein details: Q04837

    SSBP1 Human Recombinant Protein Products:

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    Novus Biologicals SSBP1 Proteins
    Novus Biologicals SSBP1 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for SSBP1

     
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    SSBP1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012340 NA-bd_OB-fold
     IPR011344 ssDNA-bd
     IPR000424 Primosome_PriB/ssb

    Graphical View of Domain Structure for InterPro Entry Q04837

    ProtoNet protein and cluster: Q04837

    2 Blocks protein domains:
    IPB000424 Single-strand binding protein
    IPB011344 Single-strand binding protein


    UniProtKB/Swiss-Prot: SSBP_HUMAN, Q04837
    Similarity: Contains 1 SSB domain


    Find genes that share domains with SSBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SSBP_HUMAN, Q04837
    Function: This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA
    replication. Associates with mitochondrial DNA

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA18063578
    GO:0003697single-stranded DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SSBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SSBP1:
     Increased circadian period len 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ssbp1):
     mortality/aging 

    Find genes that share phenotypes with SSBP1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSBP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSBP1

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSBP1

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSBP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SSBP_HUMAN, Q04837: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0042645mitochondrial nucleoid IDA18063578
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with SSBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1DNA strand elongation
    DNA replication0.63
    2Telomere C-strand (Lagging Strand) Synthesis
    Mismatch repair0.56
    3Homologous recombination
    Homologous recombination0.40


    Find genes that share SuperPaths with SSBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SSBP1
        Transcriptional activation of mitochondrial biogenesis


    3 Kegg Pathways  (Kegg details for SSBP1):
        DNA replication
    Mismatch repair
    Homologous recombination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SSBP1
    Interactions:

        GeneGlobe Interaction Network for SSBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSBP1 (Q048371, 2, 3 ENSP000002653044) via UniProtKB, MINT, STRING, and/or I2D (see all 475)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    YWHAQP273482, 3, ENSP000002380814MINT-8395092 I2D: score=1 STRING: ENSP00000238081
    AGO4Q9HCK53, ENSP000003623064I2D: score=2 STRING: ENSP00000362306
    H2AFXP161043, ENSP000003643104I2D: score=2 STRING: ENSP00000364310
    LDB1Q86U703, ENSP000003924664I2D: score=2 STRING: ENSP00000392466
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0051096positive regulation of helicase activity IDA12975372
    GO:0070584mitochondrion morphogenesis IEA--

    Find genes that share ontologies with SSBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSBP1 (SSBP)

    1 Novoseek inferred chemical compound relationship for SSBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cisplatin 4.47 1 9593724 (1)



    Find genes that share compounds with SSBP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSBP1 gene (5 alternative transcripts): 
    NM_001256510.1  NM_001256511.1  NM_001256512.1  NM_001256513.1  NM_003143.2  

    Unigene Cluster for SSBP1:

    Single-stranded DNA binding protein 1, mitochondrial
    Hs.490394  [show with all ESTs]
    Unigene Representative Sequence: BC008402
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265304(uc003vwo.1 uc010lnp.1) ENST00000496622 ENST00000498107
    ENST00000489378(uc011kri.1) ENST00000469123 ENST00000467681 ENST00000465582
    ENST00000461433 ENST00000463093 ENST00000465167 ENST00000468267 ENST00000484178
    ENST00000473783 ENST00000481508
    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSBP1
      QuantiTect SYBR Green Assays in human, mouse, rat SSBP1
      QuantiFast Probe-based Assays in human, mouse, rat SSBP1

    Additional mRNA sequence: 

    AF277319.1 AK294393.1 AK313033.1 BC000895.1 BC008402.1 BC093054.1 M94556.1 NR_046269.1 

    22 DOTS entries:

    DT.100827331  DT.121048312  DT.449737  DT.121048295  DT.95204991  DT.121048365  DT.100012076  DT.40275402 
    DT.100827329  DT.121048324  DT.121048493  DT.40133230  DT.92452888  DT.97862533  DT.101986267  DT.121048373 
    DT.454358  DT.86994620  DT.95204990  DT.100664999  DT.418620  DT.95228622 

    Selected AceView cDNA sequences (see all 540):

    BU165628 CA865614 BE905777 AV713890 BU166339 BE908327 AA969825 BQ231037 
    BU166411 CB124046 BQ222498 AI151030 BQ224728 BU076311 AA025138 BX642154 
    BM905152 AI004807 BU178289 BQ218620 AI359459 BE906191 BQ435117 BE349292 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SSBP1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:                                            -     -                                   -         
    SP2:                    -     -     -           -     -                                             
    SP3:                          -     -           -     -                                             
    SP4:                                -           -     -                                             
    SP5:                    -     -     -                                                               


    ECgene alternative splicing isoforms for SSBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATAATCTTT
    SSBP1 Expression
    About this image


    SSBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    SSBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490394
        Custom PCR Arrays for SSBP1
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SSBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SSBP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssbp11 , 5 single-stranded DNA binding protein 11, 5 90.25(n)1
    92.52(a)1
      6 (18.82 cM)5
    3817601  NM_001286663.11  NP_001273592.11 
     404713525 
    chicken
    (Gallus gallus)
    Aves SSBP11 single-stranded DNA binding protein 1, mitochondrial 77.32(n)
    81.63(a)
      418122  NM_001278007.1  NP_001264936.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSBP16
    single-stranded DNA binding protein 1, mitochondri...
    87(a)
    1 ↔ 1
    5(16186384-16196366)
    African clawed frog
    (Xenopus laevis)
    Amphibia XL2 mitochondrial DNA specific single-stranded DNA binding more 74.18(n)    X59285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.176262 Transcribed sequence with moderate similarity to protein more 79.03(n)    BQ074846.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mtSSB1 mitochondrial single stranded DNA-binding protein 47.58(n)
    44.27(a)
      41968  NM_001038968.1  NP_001034057.1 


    ENSEMBL Gene Tree for SSBP1 (if available)
    TreeFam Gene Tree for SSBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSBP1 gene

    Find genes that share paralogs with SSBP1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for SSBP1
    PGOHUM00000238384 PGOHUM00000244636 PGOHUM00000240351 PGOHUM00000243405


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSBP1 (see all 253)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1389946701,2
    --141440105(+) TTTTTA/GTATTA 6 -- int10--------
    rs1902437281,2
    --141440198(+) TTTACA/TGGAGC 6 -- int10--------
    rs752514621,2
    C,F--141440235(+) GCTTCG/CGGAAA 6 -- int11Minor allele frequency- C:0.03EA 120
    rs1414718551,2
    --141440252(+) GCATTA/GGTGTC 6 -- int10--------
    rs1508645861,2
    --141440263(+) AAGGGC/TCCTGG 6 -- int10--------
    rs69755081,2
    C,F,A,H--141440322(+) gatgcA/Cgtctc 6 -- int15Minor allele frequency- C:0.01NS EA WA 536
    rs1831843911,2
    --141440497(+) CAGTCG/TAGTCT 6 -- int10--------
    rs1884686921,2
    --141440544(+) TTTTGA/TTGCAC 6 -- int10--------
    rs1382025831,2
    C--141440551(+) GCACTA/GAAAAC 6 -- int10--------
    rs175222581,2
    C,F--141440619(+) GCTGTT/GTAATT 6 -- int14Minor allele frequency- G:0.02NA 260

    HapMap Linkage Disequilibrium report for SSBP1 (141438121 - 141487722 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SSBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34135CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for SSBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600439    OMIM disorders: --

    1 disease for SSBP1:    
    About MalaCards
    herpes simplex

    1 disease from the University of Copenhagen DISEASES database for SSBP1:
    Scrapie

    Find genes that share disorders with SSBP1           About GenesLikeMe

    1 Novoseek inferred disease relationship for SSBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 48.6 8 12645567 (2), 9593724 (1), 8063811 (1), 9446572 (1) (see all 7)

    Genetic Association Database (GAD): SSBP1
    Human Genome Epidemiology (HuGE) Navigator: SSBP1 (1 document)

    Export disorders for SSBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSBP1 gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with SSBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. (PubMed id 7789991)1, 3, 9 Tiranti V.... Zeviani M. (Genomics 1995)
    2. Cloning of human and rat cDNAs encoding the mitochondrial single- stranded DNA-binding protein (SSB). (PubMed id 8482537)1, 2, 9 Tiranti V.... Zeviani M. (Gene 1993)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The layered structure of human mitochondrial DNA nucleoids. (PubMed id 18063578)1, 2 Bogenhagen D.F.... Burke S. (J. Biol. Chem. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4-A resolution. (PubMed id 9033597)1, 2 Yang C.... Kang C. (Nat. Struct. Biol. 1997)
    7. Epstein-Barr virus immediate-early protein Zta co-opts mitochondrial single-stranded DNA binding protein to promote viral and inhibit mitochondrial DNA replication. (PubMed id 18305033)1, 9 Wiedmer A....Lieberman P.M. (J. Virol. 2008)
    8. Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. (PubMed id 11964388)1, 9 Takamatsu C....Kang D. (EMBO Rep. 2002)
    9. Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue. (PubMed id 11556757)1, 9 MA1ller-HAPcker J....Li K. (amp 2001)
    10. CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein. (PubMed id 19786724)1, 9 Radulovic M....Yu V.P. (amp 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6742 HGNC: 11317 AceView: SSBP1 Ensembl:ENSG00000106028 euGenes: HUgn6742
    ECgene: SSBP1 Kegg: 6742 H-InvDB: SSBP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SSBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSBP1 gene:
    Search GeneIP for patents involving SSBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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