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Aliases for SSBP1 Gene

Aliases for SSBP1 Gene

  • Single-Stranded DNA Binding Protein 1, Mitochondrial 2 3
  • SSBP 3 4 6
  • PWP1-Interacting Protein 17 3 4
  • Mt-SSB 3 4
  • MtSSB 3 4
  • Single-Stranded DNA-Binding Protein, Mitochondrial 3
  • Single-Stranded DNA Binding Protein 1 2
  • Single-Stranded DNA-Binding Protein 2
  • SOSS-B1 3

External Ids for SSBP1 Gene

Summaries for SSBP1 Gene

Entrez Gene Summary for SSBP1 Gene

  • SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

GeneCards Summary for SSBP1 Gene

SSBP1 (Single-Stranded DNA Binding Protein 1, Mitochondrial) is a Protein Coding gene. Diseases associated with SSBP1 include herpes simplex. Among its related pathways are Homologous recombination and DNA strand elongation. GO annotations related to this gene include chromatin binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot for SSBP1 Gene

  • This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA

Gene Wiki entry for SSBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSBP1 Gene

Genomics for SSBP1 Gene

Genomic Location for SSBP1 Gene

Start:
141,738,321 bp from pter
End:
141,787,922 bp from pter
Size:
49,602 bases
Orientation:
Plus strand

Genomic View for SSBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSBP1 Gene

Regulatory Elements for SSBP1 Gene

Proteins for SSBP1 Gene

  • Protein details for SSBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04837-SSBP_HUMAN
    Recommended name:
    Single-stranded DNA-binding protein, mitochondrial
    Protein Accession:
    Q04837
    Secondary Accessions:

    Protein attributes for SSBP1 Gene

    Size:
    148 amino acids
    Molecular mass:
    17260 Da
    Quaternary structure:
    • Homotetramer (By similarity). Interacts with MPG/AAG, through inhibition of its glycosylase activity it potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA.

    Three dimensional structures from OCA and Proteopedia for SSBP1 Gene

neXtProt entry for SSBP1 Gene

Proteomics data for SSBP1 Gene at MOPED

Post-translational modifications for SSBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys51, Lys81, and Lys122

No data available for DME Specific Peptides for SSBP1 Gene

Domains for SSBP1 Gene

UniProtKB/Swiss-Prot:

SSBP_HUMAN
Domain:
  • Contains 1 SSB domain.:
    • Q04837
genes like me logo Genes that share domains with SSBP1: view

No data available for Gene Families for SSBP1 Gene

Function for SSBP1 Gene

Molecular function for SSBP1 Gene

UniProtKB/Swiss-Prot Function: This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondrial DNA

Gene Ontology (GO) - Molecular Function for SSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 18063578
GO:0003697 single-stranded DNA binding IEA --
GO:0005515 protein binding IPI 22190034
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SSBP1: view

Phenotypes for SSBP1 Gene

MGI mutant phenotypes for SSBP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for SSBP1:
genes like me logo Genes that share phenotypes with SSBP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SSBP1 Gene

Localization for SSBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSBP1 Gene

Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSBP1 Gene COMPARTMENTS Subcellular localization image for SSBP1 gene
Compartment Confidence
mitochondrion 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0042645 mitochondrial nucleoid IDA 18063578
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SSBP1: view

Pathways for SSBP1 Gene

genes like me logo Genes that share pathways with SSBP1: view

Pathways by source for SSBP1 Gene

Gene Ontology (GO) - Biological Process for SSBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006996 organelle organization TAS --
GO:0007005 mitochondrion organization TAS --
GO:0051096 positive regulation of helicase activity IDA 12975372
GO:0070584 mitochondrion morphogenesis IEA --
genes like me logo Genes that share ontologies with SSBP1: view

Compounds for SSBP1 Gene

(1) Novoseek inferred chemical compound relationships for SSBP1 Gene

Compound -log(P) Hits PubMed IDs
cisplatin 4.47 1
genes like me logo Genes that share compounds with SSBP1: view

Transcripts for SSBP1 Gene

Unigene Clusters for SSBP1 Gene

Single-stranded DNA binding protein 1, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SSBP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - -

Relevant External Links for SSBP1 Gene

GeneLoc Exon Structure for
SSBP1
ECgene alternative splicing isoforms for
SSBP1

Expression for SSBP1 Gene

mRNA expression in normal human tissues for SSBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSBP1 Gene

SOURCE GeneReport for Unigene cluster for SSBP1 Gene Hs.490394

genes like me logo Genes that share expressions with SSBP1: view

Orthologs for SSBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SSBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSBP1 36
  • 99.55 (n)
  • 100 (a)
SSBP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSBP1 36
  • 89.12 (n)
  • 89.8 (a)
SSBP1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855532 36
  • 89.8 (n)
  • 90.48 (a)
SSBP1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssbp1 36
  • 90.25 (n)
  • 92.52 (a)
Ssbp1 16
Ssbp1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SSBP1 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SSBP1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssbp1 36
  • 89.57 (n)
  • 89.12 (a)
chicken
(Gallus gallus)
Aves SSBP1 36
  • 77.32 (n)
  • 81.63 (a)
SSBP1 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSBP1 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XL 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ssbp1 36
  • 69.48 (n)
  • 80.28 (a)
Str.1603 36
zebrafish
(Danio rerio)
Actinopterygii Dr.17626 36
ssbp1 36
  • 69.86 (n)
  • 72.6 (a)
ssbp1 37
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002477 36
  • 48.06 (n)
  • 47.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta mtSSB 36
  • 47.58 (n)
  • 44.27 (a)
mtSSB 37
  • 39 (a)
OneToOne
Species with no ortholog for SSBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SSBP1 Gene

ENSEMBL:
Gene Tree for SSBP1 (if available)
TreeFam:
Gene Tree for SSBP1 (if available)

Paralogs for SSBP1 Gene

Pseudogenes.org Pseudogenes for SSBP1 Gene

genes like me logo Genes that share paralogs with SSBP1: view

No data available for Paralogs for SSBP1 Gene

Variants for SSBP1 Gene

Sequence variations from dbSNP and Humsavar for SSBP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1803993 -- 141,743,951(+) CGGCC(A/T)GGCCT reference, synonymous-codon, nc-transcript-variant
rs1803994 -- 141,750,430(+) TCCAA(A/G)GACAA utr-variant-3-prime, nc-transcript-variant
rs1986761 -- 141,743,011(-) tgggc(A/G)tggtg intron-variant
rs2013816 -- 141,742,852(-) CACAC(C/T)CAAGA intron-variant
rs2301924 -- 141,742,413(+) CCCCT(A/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSBP1 Gene

Variant ID Type Subtype PubMed ID
esv34135 CNV Loss 18971310

Relevant External Links for SSBP1 Gene

HapMap Linkage Disequilibrium report
SSBP1

Disorders for SSBP1 Gene

(1) MalaCards Diseases for SSBP1 Gene

Search for SSBP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SSBP1 Gene

(1) Novoseek inferred disease relationships for SSBP1 Gene

Disease -log(P) Hits PubMed IDs
herpes simplex 48.6 8

Relevant External Links for SSBP1

Genetic Association Database (GAD)
SSBP1
Human Genome Epidemiology (HuGE) Navigator
SSBP1
genes like me logo Genes that share disorders with SSBP1: view

No data available for UniProtKB/Swiss-Prot for SSBP1 Gene

Publications for SSBP1 Gene

  1. Cloning of human and rat cDNAs encoding the mitochondrial single- stranded DNA-binding protein (SSB). (PMID: 8482537) Tiranti V. … Zeviani M. (Gene 1993) 3 4 23
  2. Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis. (PMID: 7789991) Tiranti V. … Zeviani M. (Genomics 1995) 2 3 23
  3. Immunocytochemical localization of mitochondrial single-stranded DNA-binding protein in mitochondria-rich cells of normal and neoplastic human tissue. (PMID: 11556757) MA1ller-HAPcker J. … Li K. (Appl. Immunohistochem. Mol. Morphol. 2001) 3 23
  4. Regulation of mitochondrial D-loops by transcription factor A and single-stranded DNA-binding protein. (PMID: 11964388) Takamatsu C. … Kang D. (EMBO Rep. 2002) 3 23
  5. Linkage mapping of the ovine single-stranded DNA-binding protein 1 (SSBP1) using microsatellite marker OARCDT7. (PMID: 12464025) Diez-TascA^n C. … Crawford A.M. (Anim. Genet. 2002) 3 23

Products for SSBP1 Gene

Sources for SSBP1 Gene

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