SSB Gene

Aliases
for SSB gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Previous GC identifers: GC02P168707 GC02P169196 GC02P170619 GC02P170857 GC02P170480 GC02P170363 GC02P162543

Summaries
for SSB gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Genomic Views
for SSB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NT_005403.18  NC_018913.2  

SwitchGear Promoter luciferase reporter plasmid: SSB promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSB

SSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P170649:  view genomic region     (about GC identifiers)

Proteins
for SSB gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

Selected PDB 3D structures from and Proteopedia for SSB (see all 9):

1OWX (3D)        1S79 (3D)        1S7A (3D)        1YTY (3D)        1ZH5 (3D)        2VOD (3D)    

Explore the universe of human proteins at neXtProt for SSB: NX_P05455

Explore proteomics data for SSB at MOPED

Post-translational modifications: 

SSB Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for SSB OriGene Protein Over-expression Lysate for SSB OriGene MassSpec for SSB OriGene Custom Protein Services for SSB
	GenScript Custom Purified and Recombinant Proteins Services for SSB
	Novus Biologicals SSB Proteins Novus Biologicals SSB Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for SSB
	Cloud-Clone Corp. Proteins for SSB
	Search eBioscience for Proteins for SSB
	Search GeneTex for Proteins for SSB
	antibodies-online proteins for SSB (18 products)
	antibodies-online peptides for SSB

SSB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for SSB
	OriGene Antibodies for SSB OriGene Custom Antibody Services for SSB
	Novus Biologicals SSB Antibodies
	Abcam antibodies for SSB
	Cloud-Clone Corp. Antibodies for SSB
	ThermoFisher Antibody for SSB
	antibodies-online antibodies for SSB (74 products)

SSB Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SSB
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SSB
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SSB Cloud-Clone Corp. CLIAs for SSB
	Search eBioscience for ELISAs for SSB
	antibodies-online kits for SSB (10 products)

Domains /
Families
for SSB gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: P05455

Find genes that share domains with SSB           About GenesLikeMe

Function
for SSB gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

(inferred from 1 allele) (MGI details for Ssb)

genOway: Develop your customized and physiologically relevant rodent model for SSB

miRNA Products:		miRTarBase miRNAs that target SSB: hsa-let-7e-5p (MIRT051494), hsa-mir-106b-3p (MIRT038547)
		Block miRNA regulation of human, mouse, rat SSB using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate SSB
		SwitchGear 3'UTR luciferase reporter plasmid: SSB 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SSB
		Predesigned siRNA for gene silencing in human, mouse, rat SSB

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SSB

Clone Products:		OriGene clones in human, mouse for SSB (see all 8) OriGene ORF clones in mouse, rat for SSB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SSB (NM_003142)
		Sino Biological Human cDNA Clone for SSB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSB
		Addgene plasmids for SSB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SSB
		Browse ESI BIO Cell Lines and PureStem Progenitors for SSB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB

Localization
for SSB gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4
cytosol	1

About this image

Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for SSB gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for SSB About     See pathways by source

Powered by

	SuperPath	Contained pathways About
1	RNA Polymerase I Promoter Opening	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.73 Systemic lupus erythematosus 0.40
2	RNA Polymerase III Transcription Initiation	RNA Polymerase III Transcription 0.88 RNA Polymerase III Transcription Termination 0.58 RNA Polymerase III Abortive And Retractive Initiation 0.88
3	Gene Expression	Gene Expression 0.40
4	Translational Control	Translational Control

1 Cell Signaling Technology (CST) Pathway for SSB

Translational Control

2 Reactome Pathways for SSB

	RNA Polymerase III Transcription Termination
	RNA Polymerase III Abortive And Retractive Initiation

1 Kegg Pathway  (Kegg details for SSB)

Systemic lupus erythematosus

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for SSB gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Transcripts
for SSB gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

Expression
for SSB gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SSB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGAAAATGG

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Ovary (Reproductive System)    fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Testis (Reproductive System)
Leydig Cells Testis Interstitium
Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

Primer Products:		OriGene qPCR primer pairs and template standards for SSB OriGene qSTAR qPCR primer pairs in human, mouse for SSB
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSB
		QuantiTect SYBR Green Assays in human, mouse, rat SSB
		QuantiFast Probe-based Assays in human, mouse, rat SSB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB

Orthologs
for SSB gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

Paralogs
for SSB gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for SSB gene

LARP7²  

3 SIMAP similar genes for SSB using alignment to 5 protein entries:     LA_HUMAN (see all proteins):

LARP1    LARP1B    LARP7

Find genes that share paralogs with SSB           About GenesLikeMe


Selected Pseudogenes.org Pseudogenes for SSB (see all 9)
PGOHUM00000239754 PGOHUM00000247080 PGOHUM00000237461 PGOHUM00000244212 PGOHUM00000238252

Genomic Variants
for SSB gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

Selected SNPs for SSB (see all 364)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1828611211,2		--	170046943(+)	CGGGCA/GCCTGT	1	--	us2k1		0	--	--	--	--
rs1487714691,2	C	--	170047018(+)	TGAGCC/TGAGGT	1	--	us2k1		0	--	--	--	--
rs2019343531,2		--	170047066(+)	TGTCT-/AAAAAA	1	--	us2k1		0	--	--	--	--
rs1155021551,2	F	--	170047096(+)	AGATAA/GAAAAG	1	--	us2k1		1		WA	118
rs1424360621,2		--	170047129(+)	AAGGAC/TCAGGG	1	--	us2k1		0	--	--	--	--
rs1873368411,2		--	170047170(+)	TTTGCC/TGGTGT	1	--	us2k1		0	--	--	--	--
rs355673481,2	C,F	--	170047353(+)	GAATGG/TATGAA	1	--	us2k1		2		NA	4
rs797473691,2	C	--	170047512(+)	TTAATT/GTGAAT	1	--	us2k1		4		WA NA EA	360
rs134311291,2	C	--	170047537(+)	CACAAC/TCCTGT	1	--	us2k1		1		NA	2
rs1513369201,2	C	--	170047578(+)	AAAGAA/CAAAAG	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SSB (170648443 - 170668575 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for SSB:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv3026	CNV	Loss	18451855
nsv10201	CNV	Loss	18304495

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SSB

DNA2.0 Custom Variant and Variant Library Synthesis for SSB

Disorders / Diseases
for SSB gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

6 diseases for SSB

8 Novoseek inferred disease relationships for SSB gene    About this table

Publications
for SSB gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. (PubMed id 18547518)^{1, 2} Kotik-Kogan O.... Curry S. (Structure 2008)
2. Structural basis for recognition and sequestration of UUU(OH) 3' termini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. (PubMed id 16387655)^{1, 2} Teplova M....Patel D.J. (Mol. Cell 2006)
3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
4. Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. (PubMed id 15004549)^{1, 2} Alfano C....Conte M.R. (Nat. Struct. Mol. Biol. 2004)
5. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)^{1, 2} Fouraux M.A.... Pruijn G.J.M. (Mol. Biol. Cell 2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PubMed id 12458796)^{1, 2} Fouraux M.A.... Pruijn G.J.M. (RNA 2002)
8. Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes. (PubMed id 9054510)^{1, 2} Fan H.... Maraie R.J. (Cell 1997)
9. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. (PubMed id 2470590)^{1, 2} Gottlieb E. and Steitz J.A. (EMBO J. 1989)
10. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PubMed id 2468131)^{1, 2} Chan E.K.L.... Tan E.M. (Nucleic Acids Res. 1989)

External Searches for SSB gene

Genome Databases showing SSB gene

Other Databases showing SSB gene

Specialized Databases showing SSB gene

Products
for SSB gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section