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SSB Gene

protein-coding GIFtS: 65
GCID: GC02P170649

Sjogren Syndrome Antigen B (Autoantigen La)

See SSB-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Sjogren Syndrome Antigen B (Autoantigen La)¹ ²		La/SSB²
La Autoantigen² ³		Autoantigen La²
Sjoegren Syndrome Type B Antigen² ³		La Ribonucleoprotein Domain Family, Member 3²
SS-B² ³		Lupus La Antigen²
LARP3² ⁵		Lupus La Protein²
La Ribonucleoprotein Domain Family¹		SS-B/La Protein²
Member 3¹		La Ribonucleoprotein³
La²

External Ids:	HGNC: 11316¹	Entrez Gene: 6741²	Ensembl: ENSG00000138385⁷	OMIM: 109090⁵	UniProtKB: P05455³

Export aliases for SSB gene to outside databases

Previous GC identifers: GC02P168707 GC02P169196 GC02P170619 GC02P170857 GC02P170480 GC02P170363 GC02P162543

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSB Gene:

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and

protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5'

and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis

C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and

systemic lupus erythematosus. (provided by RefSeq, Nov 2011)

GeneCards Summary for SSB Gene:

SSB (Sjogren syndrome antigen B (autoantigen La)) is a protein-coding gene. Diseases associated with SSB include sjogren's syndrome, and systemic lupus erythematosus. GO annotations related to this gene include tRNA binding and nucleotide binding. An important paralog of this gene is LARP7.

UniProtKB/Swiss-Prot: LA_HUMAN, P05455

Function: Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from

exonuclease digestion and facilitating their folding and maturation

Gene Wiki entry for SSB (Sjogren syndrome antigen B) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NT_005403.18 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the SSB gene promoter:
TBP C/EBPbeta p53 AP-1 ATF-2 Meis-1b POU2F1 POU2F1a c-Jun En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSB promoter sequence

Search Chromatin IP Primers for SSB

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1

SSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSB gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P170649: view genomic region (about GC identifiers)

Start:	170,648,443 bp from pter	End:	170,668,575 bp from pter
Size:	20,133 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LA_HUMAN, P05455 (See protein sequence)

Recommended Name: Lupus La protein

Size: 408 amino acids; 46837 Da

Subunit: Interacts with DDX15. May interact with RUFY1

Miscellaneous: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with

the normal cellular La protein as if this antigen was foreign

Selected PDB 3D structures from and Proteopedia for SSB (see all 9):

1OWX (3D)

1S79 (3D)

1S7A (3D)

1YTY (3D)

1ZH5 (3D)

2VOD (3D)

Secondary accessions: Q15367 Q53XJ4

Explore the universe of human proteins at neXtProt for SSB: NX_P05455

Explore proteomics data for SSB at MOPED

Post-translational modifications:

Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein¹

The N-terminus is blocked¹

Ubiquitination² at Lys9, Lys76, Lys95, Lys116, Lys176, Lys224, Lys229, Lys287, Lys312, Lys328

Modification sites at PhosphoSitePlus

See SSB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003133.1

ENSEMBL proteins:

ENSP00000397029 ENSP00000260956 ENSP00000395758 ENSP00000396890 ENSP00000386636

Reactome Protein details: P05455

SSB Human Recombinant Protein Products:

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	OriGene Purified Protein for SSB OriGene Protein Over-expression Lysate for SSB OriGene MassSpec for SSB OriGene Custom Protein Services for SSB
	GenScript Custom Purified and Recombinant Proteins Services for SSB
	Novus Biologicals SSB Proteins Novus Biologicals SSB Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	ProSpec Recombinant Protein for SSB
	Cloud-Clone Corp. Proteins for SSB
	Search eBioscience for Proteins for SSB
	antibodies-online proteins for SSB (18 products)
	antibodies-online peptides for SSB

SSB Antibody Products:

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	Novus Biologicals SSB Antibodies
	Abcam antibodies for SSB
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	antibodies-online antibodies for SSB (74 products)

SSB Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for SSB Cloud-Clone Corp. CLIAs for SSB
	Search eBioscience for ELISAs for SSB
	antibodies-online kits for SSB (10 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

LARP: La ribonucleoprotein domain containing

RBM: RNA binding motif (RRM) containing

Selected InterPro protein domains (see all 6):

IPR006630 Lupus_La_RNA-bd

IPR011991 WHTH_DNA-bd_dom

IPR002344 Lupus_La

IPR014886 RRM_3

IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry P05455

ProtoNet protein and cluster: P05455

2 Blocks protein domains:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB002344 Lupus La protein signature

UniProtKB/Swiss-Prot: LA_HUMAN, P05455

Similarity: Contains 1 HTH La-type RNA-binding domain

Similarity: Contains 1 RRM (RNA recognition motif) domain

Find genes that share domains with SSB About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: LA_HUMAN, P05455

Function: Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from

exonuclease digestion and facilitating their folding and maturation

Gene Ontology (GO): Selected molecular function terms (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000049	tRNA binding	TAS	10983981
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	--	--
GO:0003729	mRNA binding	TAS	9154801

Find genes that share ontologies with SSB About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for SSB:

Decreased p24 protein expressi

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ssb):

embryogenesis

mortality/aging

Find genes that share phenotypes with SSB About GenesLikeMe

Animal Models:
MGI mouse knock-out Ssb^tm1Rjma for SSB

genOway: Develop your customized and physiologically relevant rodent model for SSB

miRNA Products:		miRTarBase miRNAs that target SSB: hsa-let-7e-5p (MIRT051494), hsa-mir-106b-3p (MIRT038547)

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		Search for qRT-PCR Assays for microRNAs that regulate SSB
		SwitchGear 3'UTR luciferase reporter plasmid: SSB 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SSB
		Predesigned siRNA for gene silencing in human, mouse, rat SSB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SSB

Clone Products:		OriGene clones in human, mouse for SSB (see all 8) OriGene ORF clones in mouse, rat for SSB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SSB (NM_003142)
		Sino Biological Human cDNA Clone for SSB
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSB
		Addgene plasmids for SSB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SSB
		Browse ESI BIO Cell Lines and PureStem Progenitors for SSB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

LA_HUMAN, P05455: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0030529	ribonucleoprotein complex	IEA	--

Find genes that share ontologies with SSB About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SSB About

See pathways by source

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SuperPath

Contained pathways About

RNA Polymerase I Promoter Opening

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

0.73

Systemic lupus erythematosus

0.40

RNA Polymerase III Transcription Initiation

	RNA Polymerase III Transcription	0.88			RNA Polymerase III Transcription Termination	0.58
	RNA Polymerase III Abortive And Retractive Initiation	0.88

Gene Expression

Gene Expression

0.40

Translational Control

Translational Control

Find genes that share SuperPaths with SSB About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for SSB

Translational Control

2 Reactome Pathways for SSB

	RNA Polymerase III Transcription Termination
	RNA Polymerase III Abortive And Retractive Initiation

1 Kegg Pathway (Kegg details for SSB):

Systemic lupus erythematosus

Pathway & Disease-focused RT² Profiler PCR Array including SSB:

Telomeres & Telomerase in human mouse rat

Interactions:

GeneGlobe Interaction Network for SSB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for SSB (P05455^{1, 2, 3} ENSP00000260956⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 283)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K14	Q99558²^,³	MINT-48798 I2D: score=2
ENSG00000206289	P28702³	I2D: score=1
ENSG00000227322	P28702³	I2D: score=1
ENSG00000228333	P28702³	I2D: score=1
ENSG00000231321	P28702³	I2D: score=1

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006396	RNA processing	--	--
GO:0006400	tRNA modification	TAS	10983981
GO:0008334	histone mRNA metabolic process	TAS	9154801

Find genes that share ontologies with SSB About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SSB (LA)

1 Novoseek inferred chemical compound relationship for SSB gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	5.16	2	8454877 (1)

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SSB gene:

NM_003142.4

Unigene Cluster for SSB:

Sjogren syndrome antigen B (autoantigen La)

Hs.632535 [show with all ESTs]

Unigene Representative Sequence: AK124811

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000422006 ENST00000260956(uc002ufk.3) ENST00000413002 ENST00000417292

ENST00000461708 ENST00000409333(uc002ufm.3) ENST00000468600 ENST00000474273

ENST00000465871 ENST00000470621 ENST00000490914 ENST00000494051

miRNA Products:		Block miRNA regulation of human, mouse, rat SSB using miScript Target Protectors
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		GenScript: all cDNA clones in your preferred vector: SSB (NM_003142)
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		Addgene plasmids for SSB

Primer Products:		OriGene qPCR primer pairs and template standards for SSB OriGene qSTAR qPCR primer pairs in human, mouse for SSB
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SSB
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		QuantiFast Probe-based Assays in human, mouse, rat SSB

Additional mRNA sequence:

AB451228.1 AB451351.1 AK124811.1 BC001289.1 BC020818.1 BT009862.1 D28394.1 DQ185046.1

J04205.1 M20328.1 X13697.1 X14684.1 X69804.1

Selected DOTS entries (see all 35):

DT.100827681 DT.450195 DT.95374444 DT.92324971 DT.95374443 DT.86843626 DT.121009153 DT.100827688

DT.100827696 DT.121406305 DT.121009120 DT.100827693 DT.100827697 DT.100827700 DT.91751776 DT.100827691

DT.121009202 DT.91720683 DT.91728862 DT.91809273 DT.91849480 DT.91929640 DT.95374434 DT.100746510

Selected AceView cDNA sequences (see all 308):

BM762482 CR599289 CR617465 BE883435 BP350491 BC001289 CR620968 AL549494

AA160174 BQ772859 M35262 BU169383 BE883878 CR613978 CD518072 AA160173

CR608625 AL573683 CR618345 AW063947 BQ439821 BM972869 CR608623 J04205

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SSB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATGAAAATGG

About this image

SSB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 16) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Testis (Reproductive System)
Leydig Cells Testis Interstitium

Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

SSB Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SSB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.632535

Pathway & Disease-focused RT² Profiler PCR Array including SSB:

Telomeres & Telomerase in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for SSB OriGene qSTAR qPCR primer pairs in human, mouse for SSB
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SSB gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ssb^{1 , 5}	Sjogren syndrome antigen B^{1, 5}	85.63(n)¹ 81.7(a)¹		2 (40.95 cM)⁵ 20823¹ NM_009278.4¹ NP_033304.1¹ 69861562⁵
chicken (Gallus gallus)	Aves	SSB¹	Sjogren syndrome antigen B (autoantigen La)	75.66(n) 75.25(a)		395268 NM_001193669.1 NP_001180598.1
lizard (Anolis carolinensis)	Reptilia	SSB⁶	Sjogren syndrome antigen B (autoantigen La)	67(a)	1 ↔ 1	GL343362.1(559789-570976)
African clawed frog (Xenopus laevis)	Amphibia	MGC52876²	similar to Lupus LA protein homolog B	72.39(n)		BC046654.1
zebrafish (Danio rerio)	Actinopterygii	wufb17f11²	wufb17f11	73.27(n)		321504 BC045392.1
fruit fly (Drosophila melanogaster)	Insecta	La^{1 , 3}	RNA binding³ La autoantigen-like¹	35(a)³ 47.97(n)¹ 40.24(a)¹		2 38C5³ 35305¹ NM_057666.5¹ NP_477014.1¹
worm (Caenorhabditis elegans)	Secernentea	C44E4.4^{1 , 3}	RNA-binding protein³ C44E4.4¹	35(a)³ 47.08(n)¹ 35.31(a)¹		I(4634111-4635403)³ 172070¹ NM_059010.4¹ NP_491411.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	LHP1(YDL051W)⁴	RNA binding protein required for maturation of tRNA more	--		4(363952-364779) 851509 NP_010232.1

ENSEMBL Gene Tree for SSB (if available)
TreeFam Gene Tree for SSB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SSB gene

LARP7²

3 SIMAP similar genes for SSB using alignment to 5 protein entries: LA_HUMAN (see all proteins):

LARP1 LARP1B LARP7

Find genes that share paralogs with SSB About GenesLikeMe

Selected Pseudogenes.org Pseudogenes for SSB (see all 9)
PGOHUM00000239754 PGOHUM00000247080 PGOHUM00000237461 PGOHUM00000244212 PGOHUM00000238252

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182861121^1,2		--	170046943(+)	`CGGGCA/GCCTGT`	1	--	us2k¹		0	--	--	--	--
rs148771469^1,2	C	--	170047018(+)	`TGAGCC/TGAGGT`	1	--	us2k¹		0	--	--	--	--
rs201934353^1,2		--	170047066(+)	`TGTCT-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs115502155^1,2	F	--	170047096(+)	`AGATAA/GAAAAG`	1	--	us2k¹		1		WA	118
rs142436062^1,2		--	170047129(+)	`AAGGAC/TCAGGG`	1	--	us2k¹		0	--	--	--	--
rs187336841^1,2		--	170047170(+)	`TTTGCC/TGGTGT`	1	--	us2k¹		0	--	--	--	--
rs35567348^1,2	C,F	--	170047353(+)	`GAATGG/TATGAA`	1	--	us2k¹		2		NA	4
rs79747369^1,2	C	--	170047512(+)	`TTAATT/GTGAAT`	1	--	us2k¹		4		WA NA EA	360
rs13431129^1,2	C	--	170047537(+)	`CACAAC/TCCTGT`	1	--	us2k¹		1		NA	2
rs151336920^1,2	C	--	170047578(+)	`AAAGAA/CAAAAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SSB (170648443 - 170668575 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for SSB: About this table

Variant ID	Type	Subtype	PubMed ID
nsv3026	CNV	Loss	18451855
nsv10201	CNV	Loss	18304495

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 109090 OMIM disorders: --

6 diseases for SSB:
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sjogren's syndrome systemic lupus erythematosus hepatitis c virus hepatitis c

lupus erythematosus hepatitis

3 inferred disease relationships from the University of Copenhagen DISEASES database for SSB:

Von Willebrand's disease Congenital heart block Sjogren's syndrome

Find genes that share disorders with SSB About GenesLikeMe

8 Novoseek inferred disease relationships for SSB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sjogrens syndrome primary	74.7	2	16178869 (1), 12528117 (1)
sjogrens syndrome	67	5	1688881 (1), 1718461 (1), 8454877 (1), 20380108 (1)
lupus erythematosus systemic	59.1	4	9650095 (1), 12691262 (1), 1688881 (1), 16014550 (1)
autoimmune response	51.1	1	8454877 (1)
autoimmunity	48.7	5	8920873 (1), 7542577 (1), 7846070 (1), 8454877 (1)
sclerosis systemic	41.2	2	12691262 (1), 16014550 (1)
autoimmune diseases	33.8	2	1718461 (1), 20380108 (1)
inflammation	0	1	12528117 (1)

Genetic Association Database (GAD): SSB
Human Genome Epidemiology (HuGE) Navigator: SSB (18 documents)

Export disorders for SSB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SSB gene, integrated from 10 sources (see all 177):
(articles sorted by number of sources associating them with SSB)

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Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. (PubMed id 18547518)^{1, 2} Kotik-Kogan O.... Curry S. (Structure 2008)
Structural basis for recognition and sequestration of UUU(OH) 3' termini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. (PubMed id 16387655)^{1, 2} Teplova M....Patel D.J. (Mol. Cell 2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. (PubMed id 15004549)^{1, 2} Alfano C....Conte M.R. (Nat. Struct. Mol. Biol. 2004)
Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)^{1, 2} Fouraux M.A.... Pruijn G.J.M. (Mol. Biol. Cell 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PubMed id 12458796)^{1, 2} Fouraux M.A.... Pruijn G.J.M. (RNA 2002)
Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes. (PubMed id 9054510)^{1, 2} Fan H.... Maraie R.J. (Cell 1997)
Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. (PubMed id 2470590)^{1, 2} Gottlieb E. and Steitz J.A. (EMBO J. 1989)
Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PubMed id 2468131)^{1, 2} Chan E.K.L.... Tan E.M. (Nucleic Acids Res. 1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6741	HGNC: 11316	AceView: SSB	Ensembl:ENSG00000138385	euGenes: HUgn6741
ECgene: SSB	Kegg: 6741	H-InvDB: SSB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SSB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SSB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SSB gene:
Search GeneIP for patents involving SSB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Sjogren Syndrome Antigen B (Autoantigen La)

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Sjogren Syndrome Antigen B (Autoantigen La)

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