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Aliases for SSB Gene

Aliases for SSB Gene

  • Sjogren Syndrome Antigen B (Autoantigen La) 2 3
  • Sjoegren Syndrome Type B Antigen 3 4
  • La Autoantigen 3 4
  • LARP3 3 6
  • SS-B 3 4
  • La Ribonucleoprotein Domain Family, Member 3 3
  • La Ribonucleoprotein Domain Family 2
  • La Ribonucleoprotein 4
  • Lupus La Antigen 3
  • Lupus La Protein 3
  • SS-B/La Protein 3
  • Autoantigen La 3
  • Member 3 2
  • La/SSB 3
  • La 3

External Ids for SSB Gene

Previous GeneCards Identifiers for SSB Gene

  • GC02P168707
  • GC02P169196
  • GC02P170619
  • GC02P170857
  • GC02P170480
  • GC02P170363
  • GC02P162543
  • GC02P170649

Summaries for SSB Gene

Entrez Gene Summary for SSB Gene

  • The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

GeneCards Summary for SSB Gene

SSB (Sjogren Syndrome Antigen B (Autoantigen La)) is a Protein Coding gene. Diseases associated with SSB include sjogren's syndrome and hepatitis c. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include nucleotide binding and tRNA binding. An important paralog of this gene is LARP7.

UniProtKB/Swiss-Prot for SSB Gene

  • Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

Gene Wiki entry for SSB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSB Gene

Genomics for SSB Gene

Regulatory Elements for SSB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SSB Gene

Start:
169,791,933 bp from pter
End:
169,812,064 bp from pter
Size:
20,132 bases
Orientation:
Plus strand

Genomic View for SSB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSB Gene

Proteins for SSB Gene

  • Protein details for SSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05455-LA_HUMAN
    Recommended name:
    Lupus La protein
    Protein Accession:
    P05455
    Secondary Accessions:
    • Q15367
    • Q53XJ4

    Protein attributes for SSB Gene

    Size:
    408 amino acids
    Molecular mass:
    46837 Da
    Quaternary structure:
    • Interacts with DDX15. May interact with RUFY1.
    Miscellaneous:
    • Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign

    Three dimensional structures from OCA and Proteopedia for SSB Gene

neXtProt entry for SSB Gene

Proteomics data for SSB Gene at MOPED

Post-translational modifications for SSB Gene

  • Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
  • The N-terminus is blocked
  • Ubiquitination at Lys9, Lys76, Lys95, Lys116, Lys176, Lys224, Lys229, Lys287, Lys312, and Lys328
  • Modification sites at PhosphoSitePlus

Other Protein References for SSB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SSB (SSB)

No data available for DME Specific Peptides for SSB Gene

Domains for SSB Gene

Gene Families for SSB Gene

HGNC:
  • LARP :La ribonucleoprotein domain containing
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for SSB Gene

Graphical View of Domain Structure for InterPro Entry

P05455

UniProtKB/Swiss-Prot:

LA_HUMAN :
  • P05455
Domain:
  • Contains 1 HTH La-type RNA-binding domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SSB: view

Function for SSB Gene

Molecular function for SSB Gene

UniProtKB/Swiss-Prot Function: Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

Gene Ontology (GO) - Molecular Function for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding TAS 10983981
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003729 mRNA binding TAS 9154801
genes like me logo Genes that share ontologies with SSB: view

Phenotypes for SSB Gene

MGI mutant phenotypes for SSB:
inferred from 1 alleles
GenomeRNAi human phenotypes for SSB:
genes like me logo Genes that share phenotypes with SSB: view

Animal Models for SSB Gene

MGI Knock Outs for SSB:

Animal Model Products

miRNA for SSB Gene

miRTarBase miRNAs that target SSB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SSB Gene

Localization for SSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSB Gene COMPARTMENTS Subcellular localization image for SSB gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030529 ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with SSB: view

Pathways for SSB Gene

genes like me logo Genes that share pathways with SSB: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0006400 tRNA modification TAS 10983981
GO:0008334 histone mRNA metabolic process TAS 9154801
genes like me logo Genes that share ontologies with SSB: view

Compounds for SSB Gene

(1) Novoseek inferred chemical compound relationships for SSB Gene

Compound -log(P) Hits PubMed IDs
atp 5.16 1
genes like me logo Genes that share compounds with SSB: view

Transcripts for SSB Gene

Unigene Clusters for SSB Gene

Sjogren syndrome antigen B (autoantigen La):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SSB

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSB Gene

No ASD Table

Relevant External Links for SSB Gene

GeneLoc Exon Structure for
SSB
ECgene alternative splicing isoforms for
SSB

Expression for SSB Gene

mRNA expression in normal human tissues for SSB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSB Gene

SOURCE GeneReport for Unigene cluster for SSB Gene Hs.632535

genes like me logo Genes that share expressions with SSB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSB Gene

Orthologs for SSB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SSB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSB 35
  • 99.84 (n)
  • 100 (a)
SSB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SSB 35
  • 92.41 (n)
  • 94.31 (a)
SSB 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SSB 35
  • 92.76 (n)
  • 94.81 (a)
SSB 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ssb 35
  • 85.63 (n)
  • 81.7 (a)
Ssb 16
Ssb 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SSB 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ssb 35
  • 85.21 (n)
  • 82.21 (a)
chicken
(Gallus gallus)
Aves SSB 35
  • 75.66 (n)
  • 75.25 (a)
SSB 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SSB 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52876 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ssb 35
  • 67.08 (n)
  • 63.95 (a)
Str.2099 35
zebrafish
(Danio rerio)
Actinopterygii ssb 35
  • 61.98 (n)
  • 57.29 (a)
ssb 36
  • 56 (a)
OneToOne
wufb17f11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008952 35
  • 46.85 (n)
  • 39.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta La 35
  • 47.97 (n)
  • 40.24 (a)
La 36
  • 31 (a)
OneToOne
La 37
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea C44E4.4 35
  • 47.08 (n)
  • 35.31 (a)
C44E4.4 36
  • 21 (a)
OneToOne
C44E4.4 37
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LHP1 36
  • 20 (a)
OneToMany
LHP1 38
Species with no ortholog for SSB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSB Gene

ENSEMBL:
Gene Tree for SSB (if available)
TreeFam:
Gene Tree for SSB (if available)

Paralogs for SSB Gene

Paralogs for SSB Gene

Selected SIMAP similar genes for SSB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SSB: view

Variants for SSB Gene

Sequence variations from dbSNP and Humsavar for SSB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1051448 -- 169,806,893(+) TTAAG(G/T)TATGA splice-donor-variant
rs1967956 -- 169,807,574(+) cgtag(A/C)cgctg intron-variant
rs1967957 -- 169,807,576(+) tagac(A/G)ctgcg intron-variant
rs2042798 -- 169,801,438(-) GTGTT(A/T)TTTAA intron-variant
rs2114648 -- 169,797,842(-) ggtga(C/T)tggat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SSB Gene

Variant ID Type Subtype PubMed ID
nsv10201 CNV Loss 18304495
nsv3026 CNV Loss 18451855

Relevant External Links for SSB Gene

HapMap Linkage Disequilibrium report
SSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSB Gene

Disorders for SSB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (6) Diseases for SSB Gene including...

Search for SSB Gene in MalaCards »

(3) University of Copenhagen DISEASES for SSB Gene

(8) Novoseek inferred disease relationships for SSB Gene

Disease -log(P) Hits PubMed IDs
sjogrens syndrome primary 74.7 2
sjogrens syndrome 67 4
lupus erythematosus systemic 59.1 4
autoimmune response 51.1 1
autoimmunity 48.7 4

Relevant External Links for SSB

Genetic Association Database (GAD)
SSB
Human Genome Epidemiology (HuGE) Navigator
SSB
genes like me logo Genes that share disorders with SSB: view

No data available for UniProtKB/Swiss-Prot for SSB Gene

Publications for SSB Gene

  1. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. (PMID: 1692037) Kohsaka H. … Miyamoto T. (J. Clin. Invest. 1990) 3 23
  2. Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. (PMID: 14636586) Intine R.V. … Maraia R.J. (Mol. Cell 2003) 3 23
  3. Characteristics and epitope mapping of a cloned human autoantigen La. (PMID: 2452201) Sturgess A.D. … Coppel R.S. (J. Immunol. 1988) 3 4
  4. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PMID: 2468131) Chan E.K.L. … Tan E.M. (Nucleic Acids Res. 1989) 3 4
  5. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. (PMID: 2470590) Gottlieb E. … Steitz J.A. (EMBO J. 1989) 3 4

Products for SSB Gene

  • Addgene plasmids for SSB

Sources for SSB Gene

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