Aliases for SSB Gene
External Ids for SSB Gene
Previous GeneCards Identifiers for SSB Gene
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
GeneCards Summary for SSB Gene
SSB (Sjogren Syndrome Antigen B (Autoantigen La)) is a Protein Coding gene. Diseases associated with SSB include undifferentiated connective tissue disease and sjogren's syndrome. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is LARP7.
UniProtKB/Swiss-Prot for SSB Gene
Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.