Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SSB Gene

protein-coding   GIFtS: 63
GCID: GC02P170619

Sjogren Syndrome Antigen B (Autoantigen La)
Microbiology & Infectious Diseases Congress
  22 related diseases
at
MalaCards
 

Aliases
for SSB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Sjogren Syndrome Antigen B (Autoantigen La)1 2     La2
La Autoantigen2 3     Autoantigen La2
Sjoegren Syndrome Type B Antigen2 3     La Ribonucleoprotein Domain Family, Member 32
SS-B2 3     Lupus La Antigen2
LARP32 5     Lupus La Protein2
La Ribonucleoprotein Domain Family1     SS-B/La Protein2
Member 31     La Ribonucleoprotein3

External Ids:    HGNC: 113161   Entrez Gene: 67412   Ensembl: ENSG000001383857   OMIM: 1090905   UniProtKB: P054553   

Export aliases for SSB gene to outside databases

Previous GC identifers: GC02P168707 GC02P169196 GC02P170857 GC02P170480 GC02P170363 GC02P162543


Summaries
for SSB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SSB Gene:
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and
protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5'
and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis
C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and
systemic lupus erythematosus. (provided by RefSeq, Nov 2011)

GeneCards Summary for SSB Gene: 
SSB (Sjogren syndrome antigen B (autoantigen La)) is a protein-coding gene. Diseases associated with SSB include conjunctival disease, and sjogren's syndrome, and among its related super-pathways are Alcoholism. GO annotations related to this gene include tRNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: LA_HUMAN, P05455
Function: Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from
exonuclease digestion and facilitating their folding and maturation

Gene Wiki entry for SSB (Sjogren syndrome antigen B) Gene


Genomic Views
for SSB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSB gene promoter:
         TBP   C/EBPbeta   p53   AP-1   ATF-2   Meis-1b   POU2F1   POU2F1a   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SSB promoter sequence
   Search SABiosciences Chromatin IP Primers for SSB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

SSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P170619:  view genomic region     (about GC identifiers)

Start:
 170,648,443 bp from pter      End:
 170,668,575 bp from pter
Size:
 20,133 bases      Orientation:
 plus strand

Proteins
for SSB gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: LA_HUMAN, P05455 (See protein sequence)
Recommended Name: Lupus La protein  
Size: 408 amino acids; 46837 Da
Subunit: Interacts with DDX15. May interact with RUFY1
Subcellular location: Nucleus (Probable)
Miscellaneous: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with
the normal cellular La protein as if this antigen was foreign
6/9 PDB 3D structures from and Proteopedia for SSB (see all 9):
1OWX (3D)        1S79 (3D)        1S7A (3D)        1YTY (3D)        1ZH5 (3D)        2VOD (3D)    
Secondary accessions: Q15367 Q53XJ4

Explore the universe of human proteins at neXtProt for SSB: NX_P05455

Explore proteomics data for SSB at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein
  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05455

    • SSB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SSB Protein Expression
    REFSEQ proteins: NP_003133.1  
    ENSEMBL proteins: 
     ENSP00000397029   ENSP00000260956   ENSP00000395758   ENSP00000396890   ENSP00000386636  

    Human Recombinant Protein Products for SSB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SSB
    OriGene Protein Over-expression Lysate for SSB
    OriGene MassSpec for SSB 
    OriGene Custom Protein Services for SSB
    GenScript Custom Purified and Recombinant Proteins Services for SSB
    Novus Biologicals SSB Proteins
    Novus Biologicals SSB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SSB
    Cloud-Clone Corp. Proteins for SSB 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0030529ribonucleoprotein complex IEA--

    SSB for ontologies           About GeneDecksing



    SSB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SSB 
    OriGene Antibodies for SSB
    OriGene Custom Antibody Services for SSB
    GenScript Custom Superior Antibodies Services for SSB
    Novus Biologicals SSB Antibodies
    Abcam antibodies for SSB
    Cloud-Clone Corp. Antibodies for SSB 
    ThermoFisher Antibody for SSB
    LSBio Antibodies in human, mouse, rat for SSB 

    Assay Products for SSB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SSB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SSB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SSB 
    Cloud-Clone Corp. CLIAs for SSB

    Protein Domains /
    Families
    for SSB gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    LARP: La ribonucleoprotein domain containing
    RBM: RNA binding motif (RRM) containing

    5/6 InterPro protein domains (see all 6):
     IPR006630 Lupus_La_RNA-bd
     IPR011991 WHTH_DNA-bd_dom
     IPR002344 Lupus_La
     IPR014886 RRM_3
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P05455

    ProtoNet protein and cluster: P05455

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002344 Lupus La protein signature


    UniProtKB/Swiss-Prot: LA_HUMAN, P05455
    Similarity: Contains 1 HTH La-type RNA-binding domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SSB for domains           About GeneDecksing


    Function
    for SSB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LA_HUMAN, P05455
    Function: Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from
    exonuclease digestion and facilitating their folding and maturation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding TAS10983981
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003729mRNA binding TAS9154801
         
    SSB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SSB:
     Decreased p24 protein expressi 

         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ssb):
     embryogenesis  mortality/aging 

    SSB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ssbtm1Rjma for SSB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SSB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSB 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SSB
    SwitchGear 3'UTR luciferase reporter plasmid: SSB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SSB
    Sirion Biotech Customized adenovirus for overexpression of SSB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SSB (see all 9)
    OriGene ORF clones in mouse, rat for SSB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSB (NM_003142)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSB
    Sirion Biotech Customized lentivirus for stable overexpression of SSB 
                         Customized lentivirus expression plasmids for stable overexpression of SSB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SSB
    Search LifeMap BioReagents cell lines for SSB
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB


    Pathways & Interactions
    for SSB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SSB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Alcoholism
    		Systemic lupus erythematosus0.34
    2Translational Control
    		Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SSB
        Translational Control


    1         Kegg Pathway  (Kegg details for SSB):
        Systemic lupus erythematosus


    SSB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/104 Interacting proteins for SSB (P054552, 3 ENSP000002609564) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K14Q995582, 3MINT-48798 I2D: score=2 
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing ----
    GO:0006400tRNA modification TAS10983981
    GO:0008334histone mRNA metabolic process TAS9154801

    SSB for ontologies           About GeneDecksing



    Drugs & Compounds
    for SSB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SSB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSB (LA)

    1 Novoseek inferred chemical compound relationship for SSB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 5.16 2 8454877 (1)

    Search CenterWatch for drugs/clinical trials and news about SSB / LA

    Transcripts
    for SSB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SSB gene: 
    NM_003142.4  

    Unigene Cluster for SSB:

    Sjogren syndrome antigen B (autoantigen La)
    Hs.632535  [show with all ESTs]
    Unigene Representative Sequence: AK124811
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422006 ENST00000260956(uc002ufk.3) ENST00000413002 ENST00000417292
    ENST00000461708 ENST00000409333(uc002ufm.3) ENST00000468600 ENST00000474273
    ENST00000465871 ENST00000470621 ENST00000490914 ENST00000494051
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SSB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SSB
    SwitchGear 3'UTR luciferase reporter plasmid: SSB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SSB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSB
    Clone
    Products:             		 OriGene clones in human, mouse for SSB (see all 9)
    OriGene ORF clones in mouse, rat for SSB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSB (NM_003142)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSB
    Sirion Biotech Customized lentivirus for stable overexpression of SSB 
                         Customized lentivirus expression plasmids for stable overexpression of SSB 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for SSB
    OriGene qSTAR qPCR primer pairs in human, mouse for SSB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSB

    Additional mRNA sequence: 

    AB451228.1 AB451351.1 AK124811.1 BC001289.1 BC020818.1 BT009862.1 D28394.1 DQ185046.1 
    J04205.1 M20328.1 X13697.1 X14684.1 X69804.1 

    24/35 DOTS entries (see all 35):

    DT.100827681  DT.450195  DT.95374444  DT.92324971  DT.95374443  DT.86843626  DT.121009153  DT.100827688 
    DT.100827696  DT.121406305  DT.121009120  DT.100827693  DT.100827697  DT.100827700  DT.91751776  DT.100827691 
    DT.121009202  DT.91720683  DT.91728862  DT.91809273  DT.91849480  DT.91929640  DT.95374434  DT.100746510 

    24/308 AceView cDNA sequences (see all 308):

    BU618876 T29455 BM760363 CD676196 X69804 CB127687 BE856256 CD678794 
    BM922633 BQ439821 AL532603 BM785483 CA422517 BM972869 BQ014315 BP350491 
    BC020818 AH001540 BQ427702 CR598451 CA411840 CD676659 CR608623 BP368700 

    GeneLoc Exon Structure


    Expression
    for SSB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SSB expression in normal human tissues (normalized intensities)      SSB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAAATGG
    SSB Expression
    About this image


    SSB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See SSB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SSB

    SOURCE GeneReport for Unigene cluster: Hs.632535
        SABiosciences Expression via Pathway-Focused PCR Array including SSB: 
              Telomeres & Telomerase in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for SSB
    OriGene qSTAR qPCR primer pairs in human, mouse for SSB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SSB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSB
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB

    Orthologs
    for SSB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SSB gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ssb1 , 5 Sjogren syndrome antigen B1, 5 85.63(n)1
    81.7(a)1    		   2 (40.95 cM)5
    208231  NM_001110145.11  NP_001103615.11 
     698615625 
    chicken
    (Gallus gallus)    		 Aves SSB1 Sjogren syndrome antigen B (autoantigen La) 75.66(n)
    75.25(a)    		   395268  NM_001193669.1  NP_001180598.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SSB6
    		 Uncharacterized protein
    		 67(a)
    		 1 ↔ 1
    		 GL343362.1(559789-570976)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC528762 similar to Lupus LA protein homolog B 72.39(n)    BC046654.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufb17f112 wufb17f11 73.27(n)   321504  BC045392.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta La1 , 3 RNA binding3
    La autoantigen-like1    		 35(a)3
    46.69(n)1
    39.16(a)1    		   2 38C53
    353051  NM_057666.41  NP_477014.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C44E4.41 , 3 RNA-binding protein3
    Protein C44E4.41    		 35(a)3
    46.91(n)1
    35.11(a)1    		   I(4634111-4635403)3
    1720701  NM_059010.31  NP_491411.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes LHP1(YDL051W)4 RNA binding protein required for maturation of tRNA more   --   4(363952-364779) 851509  NP_010232.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons La11 La protein 1 43.85(n)
    30.94(a)    		   829408  NM_119425.4  NP_567904.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g06104001 hypothetical protein 43.4(n)
    31.77(a)    		   4329949  NM_001053933.1  NP_001047398.1 


    ENSEMBL Gene Tree for SSB (if available)
    TreeFam Gene Tree for SSB (if available)

    Paralogs
    for SSB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SSB gene
    3 SIMAP similar genes for SSB using alignment to 5 protein entries:     LA_HUMAN (see all proteins):
    LARP1    LARP1B    LARP7

    SSB for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for SSB (see all 9)
    PGOHUM00000239754 PGOHUM00000247080 PGOHUM00000237461 PGOHUM00000244212 PGOHUM00000238252


    Genomic Variants
    for SSB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/364 SNPs in SSB are shown (see all 364)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0340664
    		----see VAR_0340662 P S mis40--------
    rs1828611211,2
    		--170046943(+) CGGGCA/GCCTGT 1 -- us2k10--------
    rs1487714691,2
    		C--170047018(+) TGAGCC/TGAGGT 1 -- us2k10--------
    rs2019343531,2
    		--170047066(+) TGTCT-/AAAAAA 1 -- us2k10--------
    rs1155021551,2
    		F--170047096(+) AGATAA/GAAAAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1424360621,2
    		--170047129(+) AAGGAC/TCAGGG 1 -- us2k10--------
    rs1873368411,2
    		--170047170(+) TTTGCC/TGGTGT 1 -- us2k10--------
    rs355673481,2
    		C,F--170047353(+) GAATGG/TATGAA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs797473691,2
    		C--170047512(+) TTAATT/GTGAAT 1 -- us2k14Minor allele frequency- G:0.11WA NA EA 360
    rs134311291,2
    		C--170047537(+) CACAAC/TCCTGT 1 -- us2k11Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for SSB (170648443 - 170668575 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SSB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3026CNV Loss18451855
    nsv10201CNV Loss18304495

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSB
    DNA2.0 Custom Variant and Variant Library Synthesis for SSB

    Disorders / Diseases
    for SSB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 109090    OMIM disorders: --

    20/22 diseases for SSB (see all 22):    About MalaCards
    conjunctival disease    sjogren's syndrome    japanese encephalitis    parotitis
    congenital heart block    dry eye syndrome    hepatitis c    sialadenitis
    lupus erythematosus    cutaneous lupus erythematosus    systemic lupus erythematosus    hepatitis a
    mixed connective tissue disease    connective tissue disease    von willebrand's disease    hepatitis
    keratoconjunctivitis    polymyositis    rheumatic disease    encephalitis

    3 diseases from the University of Copenhagen DISEASES database for SSB:
    Von Willebrand's disease     Congenital heart block     Sjogren's syndrome

    SSB for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for SSB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sjogrens syndrome primary 74.7 2 16178869 (1), 12528117 (1)
    sjogrens syndrome 67 5 1688881 (1), 1718461 (1), 8454877 (1), 20380108 (1)
    lupus erythematosus systemic 59.1 4 9650095 (1), 12691262 (1), 1688881 (1), 16014550 (1)
    autoimmune response 51.1 1 8454877 (1)
    autoimmunity 48.7 5 8920873 (1), 7542577 (1), 7846070 (1), 8454877 (1)
    sclerosis systemic 41.2 2 12691262 (1), 16014550 (1)
    autoimmune diseases 33.8 2 1718461 (1), 20380108 (1)
    inflammation 0 1 12528117 (1)

    Genetic Association Database (GAD): SSB
    Human Genome Epidemiology (HuGE) Navigator: SSB (18 documents)

    Export disorders for SSB gene to outside databases

    Publications
    for SSB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SSB gene, integrated from 9 sources (see all 175):
    (articles sorted by number of sources associating them with SSB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. (PubMed id 18547518)1, 2 Kotik-Kogan O....Curry S. (2008)
    2. Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. (PubMed id 16387655)1, 2 Teplova M....Patel D.J. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. (PubMed id 15004549)1, 2 Alfano C....Conte M.R. (2004)
    5. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)1, 2 Fouraux M.A.... Pruijn G.J.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PubMed id 12458796)1, 2 Fouraux M.A.... Pruijn G.J.M. (2002)
    8. Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes. (PubMed id 9054510)1, 2 Fan H.... Maraie R.J. (1997)
    9. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. (PubMed id 2470590)1, 2 Gottlieb E. and Steitz J.A. (1989)
    10. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PubMed id 2468131)1, 2 Chan E.K.L.... Tan E.M. (1989)

    External Searches for SSB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SSB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6741 HGNC: 11316 AceView: SSB Ensembl:ENSG00000138385 euGenes: HUgn6741
    ECgene: SSB Kegg: 6741 H-InvDB: SSB

    Other Databases showing SSB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SSB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SSB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SSB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SSB gene:
    Search GeneIP for patents involving SSB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SSB gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SSB   OriGene RNAi products in human, mouse, rat for SSB  
     OriGene qPCR primer pairs and template standards for SSB   OriGene Protein Over-expression Lysate for SSB  
     OriGene MassSpec something-or-other for SSB   OriGene clones in human, mouse for SSB  
     OriGene qSTAR qPCR primer pairs in human, mouse for SSB   OriGene Purified Protein for SSB  
     OriGene ORF clones in mouse, rat for SSB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SSB   OriGene Custom Protein Services for SSB  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SSB
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SSB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SSB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SSB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SSB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SSB
     GenScript Custom Purified and Recombinant Proteins Services for SSB GenScript cDNA clones with any tag delivered in your preferred vector for SSB
     GenScript Custom Assay Services for SSB GenScript Custom Superior Antibodies Services for SSB
     GenScript Custom overexpressing Cell Line Services for SSB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SSB 

     Regulatory tfbs in SSB promoter
     Search Chromatin IP Primers for SSB
     RT2 qPCR Primer Assay in human, mouse, rat SSB
     GNC Network for SSB
     SABiosciences PCR Arrays including human, mouse, rat SSB
     Search Tocris compounds for SSB (LA)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SSB antibodies
     SSB proteins
     SSB lysates
     Antibodies for SSB
     See all of Abcam's Antibodies, Kits and Proteins for SSB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SSB




     Proteins for SSB
     Antibodies for SSB
     ELISAs for SSB
     CLIAs for SSB
     Search LifeMap BioReagents cell lines for SSB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB
     SwitchGear 3'UTR luciferase reporter plasmids for SSB
     SwitchGear Promoter luciferase reporter plasmids for SSB
     ThermoFisher Antibody for SSB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SSB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SSB
    Customized:
     lentivirus for stable overexpression of SSB
     lentivirus expression plasmids for stable overexpression of SSB
     adenovirus for overexpression of SSB
     LSBio Antibodies in human, mouse, rat for SSB
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SSB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4