Aliases for SSB Gene
Aliases for SSB Gene
External Ids for SSB Gene
- HGNC: 11316
- Entrez Gene: 6741
- Ensembl: ENSG00000138385
- OMIM: 109090
- UniProtKB: P05455
Previous GeneCards Identifiers for SSB Gene
- GC02P168707
- GC02P169196
- GC02P170619
- GC02P170857
- GC02P170480
- GC02P170363
- GC02P162543
- GC02P170649
Summaries for SSB Gene
-
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]
GeneCards Summary for SSB Gene
SSB (Sjogren Syndrome Antigen B) is a Protein Coding gene. Diseases associated with SSB include Sjogren Syndrome and Systemic Lupus Erythematosus. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.
UniProtKB/Swiss-Prot for SSB Gene
-
Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSB Gene
Genomics for SSB Gene
GeneHancer (GH) Regulatory Elements for SSB Gene
Promoters and enhancers for SSB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SSB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SSB Gene
Genomic Locations for SSB Gene
- chr2:169,791,933-169,812,064
- (GRCh38/hg38)
- Size:
- 20,132 bases
- Orientation:
- Plus strand
- chr2:170,648,443-170,668,575
- (GRCh37/hg19)
Genomic View for SSB Gene
Genes around SSB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
SSB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SSB Gene
Proteins for SSB Gene
-
Protein details for SSB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P05455-LA_HUMAN
- Recommended name:
- Lupus La protein
- Protein Accession:
- P05455
- Q15367
- Q53XJ4
Protein attributes for SSB Gene
- Size:
- 408 amino acids
- Molecular mass:
- 46837 Da
- Quaternary structure:
-
- Interacts with DDX15. May interact with RUFY1.
- Miscellaneous:
-
- Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.
Protein Expression for SSB Gene
Post-translational modifications for SSB Gene
- Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
- The N-terminus is blocked.
- Ubiquitination at isoforms=9, posLast=7676, isoforms=95, posLast=116116, isoforms=176, posLast=224224, isoforms=229, isoforms=287, posLast=312312, and posLast=328328
Other Protein References for SSB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for SSB (SSB)
- Novus Biologicals Antibodies for SSB
-
Abcam antibodies for SSB
- Invitrogen Antibodies for SSB
- antibodies-online: Search results for available SSB related products ranked by validation data
- GeneTex SSB antibody for SSB
-
Santa Cruz Biotechnology (SCBT) Antibodies for SSB
Protein Products
-
OriGene Purified Proteins for SSB
- Search Origene for MassSpec and Protein Over-expression Lysates for SSB
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- antibodies-online: Search results for available SSB related products ranked by validation data
- Search GeneTex for Proteins for SSB
-
Abcam proteins for SSB
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for SSB
- antibodies-online: Search results for available SSB related products ranked by validation data
No data available for DME Specific Peptides for SSB Gene
Domains & Families for SSB Gene
Gene Families for SSB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SSB Gene
Suggested Antigen Peptide Sequences for SSB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for SSB Gene
Function for SSB Gene
Molecular function for SSB Gene
- UniProtKB/Swiss-Prot Function:
- Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Phenotypes From GWAS Catalog for SSB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000049 | tRNA binding | IMP | 10983981 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IMP | 3192525 |
| GO:0003729 | mRNA binding | TAS | 9154801 |
| GO:0005515 | protein binding | IPI | 23552417 |
Phenotypes for SSB Gene
- MGI mutant phenotypes for SSB:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for SSB:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SSB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SSB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SSB gene
- Search ViGene Biosciences for SSB
CRISPR Products
-
OriGene CRISPR knockouts for SSB
- genomics-online: gRNA clones - Search results for available SSB gene related products
- Applied Biological Materials CRISPR for SSB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SSB
- GenScript: Design CRISPR guide RNA sequences for SSB
miRNA for SSB Gene
- miRTarBase miRNAs that target SSB
miRNA Products
- Search ViGene Biosciences for SSB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SSB
- Browse OriGene Inhibitory RNA Products For SSB
- genomics-online: shRNA clones - Search results for available SSB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SSB gene
Clone Products
- Sino Biological Human cDNA Clone for SSB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SSB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SSB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SSB
- genomics-online: cdna clones - Search results for available SSB gene related products
- orf clones - Search results for available SSB gene related products
- Applied Biological Materials Clones for SSB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for SSB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SSB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SSB gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSB Gene
Localization for SSB Gene
Subcellular locations from UniProtKB/Swiss-Prot for SSB Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | IDA,HDA | 19135898 |
| GO:0005634 | nucleus | IDA | 17308035 |
| GO:0005737 | cytoplasm | IDA | 17308035 |
| GO:0030529 | intracellular ribonucleoprotein complex | TAS,IEA | -- |
Pathways & Interactions for SSB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA Polymerase III Transcription Initiation | ||
| 2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 3 | Translational Control | ||
| 4 | Gene Expression |
.48
|
|
Pathways by source for SSB Gene
1 Cell Signaling Technology pathway for SSB Gene
1 KEGG pathway for SSB Gene
Interacting Proteins for SSB Gene
Selected Interacting proteins:
ENSP00000260956
P05455-LA_HUMAN
for SSB Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001682 | tRNA 5-leader removal | IGI | 10983981 |
| GO:0006396 | RNA processing | IEA | -- |
| GO:0006400 | tRNA modification | TAS | 10983981 |
| GO:0006409 | tRNA export from nucleus | IMP | 17308035 |
| GO:0008033 | tRNA processing | IMP | 17308035 |
Transcripts for SSB Gene
mRNA/cDNA for SSB Gene
- (2) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (308) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SSB Gene
CRISPR Products
-
OriGene CRISPR knockouts for SSB
- genomics-online: gRNA clones - Search results for available SSB gene related products
- Applied Biological Materials CRISPR for SSB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SSB
- GenScript: Design CRISPR guide RNA sequences for SSB
miRNA Products
- Search ViGene Biosciences for SSB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SSB
- Browse OriGene Inhibitory RNA Products For SSB
- genomics-online: shRNA clones - Search results for available SSB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SSB gene
Clone Products
- Sino Biological Human cDNA Clone for SSB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SSB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SSB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SSB
- genomics-online: cdna clones - Search results for available SSB gene related products
- orf clones - Search results for available SSB gene related products
- Applied Biological Materials Clones for SSB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SSB Gene
This gene is overexpressed in Peripheral blood mononuclear cells (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SSB Gene:
SSBSOURCE GeneReport for Unigene cluster for SSB Gene:
Hs.632535Evidence on tissue expression from TISSUES for SSB Gene
- Liver(4.5)
- Muscle(4.5)
- Nervous system(4)
- Heart(2.7)
- Kidney(2.5)
- Spleen(2.5)
- Blood(2.3)
- Eye(2.3)
- Skin(2.3)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for SSB
-
OriGene qPCR primer pairs and template standards for SSB
- genomics-online: primer clones - Search results for available SSB gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SSB Gene
Orthologs for SSB Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SSB 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | SSB 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | SSB 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ssb 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ssb 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | SSB 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | SSB 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SSB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ssb 33 |
|
||
| Str.2099 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52876 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ssb 33 34 |
|
||
| wufb17f11 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | La 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008952 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | C44E4.4 35 33 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LHP1 34 36 |
|
OneToMany |
- Species where no ortholog for SSB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SSB Gene
(3) SIMAP similar genes for SSB Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for SSB Gene
No data available for Paralogs for SSB Gene
Variants for SSB Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000062870 | -- | 169,812,221(+) | T/C | downstream_transcript_variant | |
| rs1000367676 | -- | 169,805,228(+) | A/G | intron_variant | |
| rs1000399055 | -- | 169,812,515(+) | C/T | downstream_transcript_variant | |
| rs1000745872 | -- | 169,809,125(+) | A/G | intron_variant | |
| rs1000749513 | -- | 169,801,955(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.69;
32.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SSB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SSB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSB Gene
Disorders for SSB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sjogren syndrome |
|
|
| systemic lupus erythematosus |
|
|
| lupus erythematosus |
|
|
| undifferentiated connective tissue disease |
|
|
| hepatitis c virus |
|
|
Search SSB in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SSB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for SSB Gene
Publications for SSB Gene
- Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. (PMID: 1692037) Kohsaka H … Miyamoto T (The Journal of clinical investigation 1990) 2 3 22 58
- Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PMID: 2468131) Chan EK … Tan EM (Nucleic acids research 1989) 2 3 4 58
- Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. (PMID: 18547518) Kotik-Kogan O … Curry S (Structure (London, England : 1993) 2008) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. (PMID: 16387655) Teplova M … Patel DJ (Molecular cell 2006) 3 4 58
Products for SSB Gene
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for SSB
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- CloneReady with Over 120,000 Genes
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- Sino Biological Transfection Reagent
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- Abcam antibodies for SSB
- Abcam proteins for SSB
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SSB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for SSB
- VectorBuilder custom plasmid, inducible vectors for SSB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SSB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SSB
- antibodies-online: Search results for available SSB related products ranked by validation data
- antibodies-online: Search results for available SSB related products ranked by validation data
- antibodies-online: Search results for available SSB related products ranked by validation data
- GeneTex SSB antibody for SSB
- Search GeneTex for Proteins for SSB
- ViGene Biosciences adenoviral particle packaged cDNA for SSB gene
- ViGene Biosciences lentiviral particle packaged cDNA for SSB gene
- ViGene Biosciences ready-to-package AAV shRNAs for SSB gene
- Search ViGene Biosciences for SSB
- Santa Cruz Biotechnology (SCBT) Antibodies for SSB
- Search Santa Cruz Biotechnology (SCBT) for SSB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SSB
- genomics-online: cdna clones - Search results for available SSB gene related products
- orf clones - Search results for available SSB gene related products
- genomics-online: gRNA clones - Search results for available SSB gene related products
- genomics-online: primer clones - Search results for available SSB gene related products
- genomics-online: shRNA clones - Search results for available SSB gene related products
Sources for SSB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
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