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SSB Gene

protein-coding   GIFtS: 65
GCID: GC02P170649

Sjogren Syndrome Antigen B (Autoantigen La)

  See SSB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sjogren Syndrome Antigen B (Autoantigen La)1 2     La/SSB2
La Autoantigen2 3     Autoantigen La2
Sjoegren Syndrome Type B Antigen2 3     La Ribonucleoprotein Domain Family, Member 32
SS-B2 3     Lupus La Antigen2
LARP32 5     Lupus La Protein2
La Ribonucleoprotein Domain Family1     SS-B/La Protein2
Member 31     La Ribonucleoprotein3
La2     

External Ids:    HGNC: 113161   Entrez Gene: 67412   Ensembl: ENSG000001383857   OMIM: 1090905   UniProtKB: P054553   

Export aliases for SSB gene to outside databases

Previous GC identifers: GC02P168707 GC02P169196 GC02P170619 GC02P170857 GC02P170480 GC02P170363 GC02P162543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SSB Gene:
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and
protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5'
and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis
C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and
systemic lupus erythematosus. (provided by RefSeq, Nov 2011)

GeneCards Summary for SSB Gene:
SSB (Sjogren syndrome antigen B (autoantigen La)) is a protein-coding gene. Diseases associated with SSB include sjogren's syndrome, and hepatitis c. GO annotations related to this gene include tRNA binding and nucleotide binding. An important paralog of this gene is LARP7.

UniProtKB/Swiss-Prot: LA_HUMAN, P05455
Function: Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from
exonuclease digestion and facilitating their folding and maturation

Gene Wiki entry for SSB (Sjogren syndrome antigen B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SSB gene promoter:
         TBP   C/EBPbeta   p53   AP-1   ATF-2   Meis-1b   POU2F1   POU2F1a   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSSB promoter sequence
   Search Chromatin IP Primers for SSB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SSB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

SSB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P170649:  view genomic region     (about GC identifiers)

Start:
170,648,443 bp from pter      End:
170,668,575 bp from pter
Size:
20,133 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LA_HUMAN, P05455 (See protein sequence)
Recommended Name: Lupus La protein  
Size: 408 amino acids; 46837 Da
Subunit: Interacts with DDX15. May interact with RUFY1
Miscellaneous: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with
the normal cellular La protein as if this antigen was foreign
Selected PDB 3D structures from and Proteopedia for SSB (see all 9):
1OWX (3D)        1S79 (3D)        1S7A (3D)        1YTY (3D)        1ZH5 (3D)        2VOD (3D)    
Secondary accessions: Q15367 Q53XJ4

Explore the universe of human proteins at neXtProt for SSB: NX_P05455

Explore proteomics data for SSB at MOPED

Post-translational modifications: 

  • Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein1
  • The N-terminus is blocked1
  • Ubiquitination2 at Lys9, Lys76, Lys95, Lys116, Lys176, Lys224, Lys229, Lys287, Lys312, Lys328
  • Modification sites at PhosphoSitePlus

  • See SSB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003133.1  
    ENSEMBL proteins: 
     ENSP00000397029   ENSP00000260956   ENSP00000395758   ENSP00000396890   ENSP00000386636  
    Reactome Protein details: P05455

    SSB Human Recombinant Protein Products:

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    Novus Biologicals SSB Proteins
    Novus Biologicals SSB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for SSB
    Cloud-Clone Corp. Proteins for SSB

     
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    SSB Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LARP: La ribonucleoprotein domain containing
    RBM: RNA binding motif (RRM) containing

    Selected InterPro protein domains (see all 6):
     IPR006630 Lupus_La_RNA-bd
     IPR011991 WHTH_DNA-bd_dom
     IPR002344 Lupus_La
     IPR014886 RRM_3
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P05455

    ProtoNet protein and cluster: P05455

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002344 Lupus La protein signature


    UniProtKB/Swiss-Prot: LA_HUMAN, P05455
    Similarity: Contains 1 HTH La-type RNA-binding domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SSB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LA_HUMAN, P05455
    Function: Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from
    exonuclease digestion and facilitating their folding and maturation

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000049tRNA binding TAS10983981
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003729mRNA binding TAS9154801
         
    Find genes that share ontologies with SSB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SSB:
     Decreased p24 protein expressi 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ssb):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with SSB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ssbtm1Rjma for SSB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SSB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SSB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SSB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SSB

    miRNA
    Products:
        
    miRTarBase miRNAs that target SSB:
    hsa-let-7e-5p (MIRT051494), hsa-mir-106b-3p (MIRT038547)

    Block miRNA regulation of human, mouse, rat SSB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SSB
    SwitchGear 3'UTR luciferase reporter plasmidSSB 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SSB
    Predesigned siRNA for gene silencing in human, mouse, rat SSB

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for SSB
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    GenScript: all cDNA clones in your preferred vector: SSB (NM_003142)
    Sino Biological Human cDNA Clone for SSB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSB
    Addgene plasmids for SSB 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LA_HUMAN, P05455: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0030529ribonucleoprotein complex IEA--

    Find genes that share ontologies with SSB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SSB About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    Systemic lupus erythematosus0.40
    2RNA Polymerase III Transcription Initiation
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Termination0.58
    RNA Polymerase III Transcription0.88
    3Gene Expression
    Gene Expression0.40
    4Translational Control
    Translational Control


    Find genes that share SuperPaths with SSB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SSB
        Translational Control


    2 Reactome Pathways for SSB
        RNA Polymerase III Transcription Termination
    RNA Polymerase III Abortive And Retractive Initiation


    1 Kegg Pathway  (Kegg details for SSB):
        Systemic lupus erythematosus

        Pathway & Disease-focused RT2 Profiler PCR Array including SSB: 
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SSB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SSB (P054551, 2, 3 ENSP000002609564) via UniProtKB, MINT, STRING, and/or I2D (see all 283)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K14Q995582, 3MINT-48798 I2D: score=2 
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing ----
    GO:0006400tRNA modification TAS10983981
    GO:0008334histone mRNA metabolic process TAS9154801

    Find genes that share ontologies with SSB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SSB (LA)

    1 Novoseek inferred chemical compound relationship for SSB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 5.16 2 8454877 (1)



    Find genes that share compounds with SSB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SSB gene: 
    NM_003142.4  

    Unigene Cluster for SSB:

    Sjogren syndrome antigen B (autoantigen La)
    Hs.632535  [show with all ESTs]
    Unigene Representative Sequence: AK124811
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422006 ENST00000260956(uc002ufk.3) ENST00000413002 ENST00000417292
    ENST00000461708 ENST00000409333(uc002ufm.3) ENST00000468600 ENST00000474273
    ENST00000465871 ENST00000470621 ENST00000490914 ENST00000494051
    miRNA
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    Block miRNA regulation of human, mouse, rat SSB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SSB
    SwitchGear 3'UTR luciferase reporter plasmidSSB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SSB
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    OriGene ORF clones in mouse, rat for SSB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SSB (NM_003142)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SSB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SSB
    Addgene plasmids for SSB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SSB
    OriGene qSTAR qPCR primer pairs in human, mouse for SSB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SSB
      QuantiTect SYBR Green Assays in human, mouse, rat SSB
      QuantiFast Probe-based Assays in human, mouse, rat SSB

    Additional mRNA sequence: 

    AB451228.1 AB451351.1 AK124811.1 BC001289.1 BC020818.1 BT009862.1 D28394.1 DQ185046.1 
    J04205.1 M20328.1 X13697.1 X14684.1 X69804.1 

    Selected DOTS entries (see all 35):

    DT.100827681  DT.450195  DT.95374444  DT.92324971  DT.95374443  DT.86843626  DT.121009153  DT.100827688 
    DT.100827696  DT.121406305  DT.121009120  DT.100827693  DT.100827697  DT.100827700  DT.91751776  DT.100827691 
    DT.121009202  DT.91720683  DT.91728862  DT.91809273  DT.91849480  DT.91929640  DT.95374434  DT.100746510 

    Selected AceView cDNA sequences (see all 308):

    BM762482 CR599289 CR617465 BE883435 BP350491 BC001289 CR620968 AL549494 
    AA160174 BQ772859 M35262 BU169383 BE883878 CR613978 CD518072 AA160173 
    CR608625 AL573683 CR618345 AW063947 BQ439821 BM972869 CR608623 J04205 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SSB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAAATGG
    SSB Expression
    About this image


    SSB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SSB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SSB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632535
        Pathway & Disease-focused RT2 Profiler PCR Array including SSB: 
              Telomeres & Telomerase in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SSB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SSB gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ssb1 , 5 Sjogren syndrome antigen B1, 5 85.63(n)1
    81.7(a)1
      2 (40.95 cM)5
    208231  NM_009278.41  NP_033304.11 
     698615625 
    chicken
    (Gallus gallus)
    Aves SSB1 Sjogren syndrome antigen B (autoantigen La) 75.66(n)
    75.25(a)
      395268  NM_001193669.1  NP_001180598.1 
    lizard
    (Anolis carolinensis)
    Reptilia SSB6
    Sjogren syndrome antigen B (autoantigen La)
    67(a)
    1 ↔ 1
    GL343362.1(559789-570976)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528762 similar to Lupus LA protein homolog B 72.39(n)    BC046654.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb17f112 wufb17f11 73.27(n)   321504  BC045392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta La1 , 3 RNA binding3
    La autoantigen-like1
    35(a)3
    47.97(n)1
    40.24(a)1
      2 38C53
    353051  NM_057666.51  NP_477014.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C44E4.41 , 3 RNA-binding protein3
    C44E4.41
    35(a)3
    47.08(n)1
    35.31(a)1
      I(4634111-4635403)3
    1720701  NM_059010.41  NP_491411.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LHP1(YDL051W)4 RNA binding protein required for maturation of tRNA more   --   4(363952-364779) 851509  NP_010232.1 


    ENSEMBL Gene Tree for SSB (if available)
    TreeFam Gene Tree for SSB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SSB gene
    LARP72  
    3 SIMAP similar genes for SSB using alignment to 5 protein entries:     LA_HUMAN (see all proteins):
    LARP1    LARP1B    LARP7

    Find genes that share paralogs with SSB           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for SSB (see all 9)
    PGOHUM00000239754 PGOHUM00000247080 PGOHUM00000237461 PGOHUM00000244212 PGOHUM00000238252


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SSB (see all 364)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828611211,2
    --170046943(+) CGGGCA/GCCTGT 1 -- us2k10--------
    rs1487714691,2
    C--170047018(+) TGAGCC/TGAGGT 1 -- us2k10--------
    rs2019343531,2
    --170047066(+) TGTCT-/AAAAAA 1 -- us2k10--------
    rs1155021551,2
    F--170047096(+) AGATAA/GAAAAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1424360621,2
    --170047129(+) AAGGAC/TCAGGG 1 -- us2k10--------
    rs1873368411,2
    --170047170(+) TTTGCC/TGGTGT 1 -- us2k10--------
    rs355673481,2
    C,F--170047353(+) GAATGG/TATGAA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs797473691,2
    C--170047512(+) TTAATT/GTGAAT 1 -- us2k14Minor allele frequency- G:0.11WA NA EA 360
    rs134311291,2
    C--170047537(+) CACAAC/TCCTGT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1513369201,2
    C--170047578(+) AAAGAA/CAAAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SSB (170648443 - 170668575 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SSB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3026CNV Loss18451855
    nsv10201CNV Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SSB
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 109090    OMIM disorders: --

    6 diseases for SSB:    
    About MalaCards
    sjogren's syndrome    hepatitis c    lupus erythematosus    hepatitis c virus
    hepatitis    systemic lupus erythematosus

    3 diseases from the University of Copenhagen DISEASES database for SSB:
    Von Willebrand's disease     Congenital heart block     Sjogren's syndrome

    Find genes that share disorders with SSB           About GenesLikeMe

    8 Novoseek inferred disease relationships for SSB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sjogrens syndrome primary 74.7 2 16178869 (1), 12528117 (1)
    sjogrens syndrome 67 5 1688881 (1), 1718461 (1), 8454877 (1), 20380108 (1)
    lupus erythematosus systemic 59.1 4 9650095 (1), 12691262 (1), 1688881 (1), 16014550 (1)
    autoimmune response 51.1 1 8454877 (1)
    autoimmunity 48.7 5 8920873 (1), 7542577 (1), 7846070 (1), 8454877 (1)
    sclerosis systemic 41.2 2 12691262 (1), 16014550 (1)
    autoimmune diseases 33.8 2 1718461 (1), 20380108 (1)
    inflammation 0 1 12528117 (1)

    Genetic Association Database (GAD): SSB
    Human Genome Epidemiology (HuGE) Navigator: SSB (18 documents)

    Export disorders for SSB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SSB gene, integrated from 10 sources (see all 177):
    (articles sorted by number of sources associating them with SSB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. (PubMed id 18547518)1, 2 Kotik-Kogan O.... Curry S. (Structure 2008)
    2. Structural basis for recognition and sequestration of UUU(OH) 3' termini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. (PubMed id 16387655)1, 2 Teplova M....Patel D.J. (Mol. Cell 2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein. (PubMed id 15004549)1, 2 Alfano C....Conte M.R. (Nat. Struct. Mol. Biol. 2004)
    5. Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes. (PubMed id 14617813)1, 2 Fouraux M.A.... Pruijn G.J.M. (Mol. Biol. Cell 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The human La (SS-B) autoantigen interacts with DDX15/hPrp43, a putative DEAH-box RNA helicase. (PubMed id 12458796)1, 2 Fouraux M.A.... Pruijn G.J.M. (RNA 2002)
    8. Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes. (PubMed id 9054510)1, 2 Fan H.... Maraie R.J. (Cell 1997)
    9. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. (PubMed id 2470590)1, 2 Gottlieb E. and Steitz J.A. (EMBO J. 1989)
    10. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PubMed id 2468131)1, 2 Chan E.K.L.... Tan E.M. (Nucleic Acids Res. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6741 HGNC: 11316 AceView: SSB Ensembl:ENSG00000138385 euGenes: HUgn6741
    ECgene: SSB Kegg: 6741 H-InvDB: SSB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SSB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SSB gene:
    Search GeneIP for patents involving SSB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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