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SSB Gene(Protein Coding)

Sjogren Syndrome Antigen B

GCID:
GC02P169791
GIFtS:
63
Genes Participants
UDN Logo

Aliases for SSB Gene

Aliases for SSB Gene

  • Sjogren Syndrome Antigen B 2 3 5
  • La Autoantigen 2 3 4
  • Sjogren Syndrome Antigen B (Autoantigen La) 2 3
  • Sjoegren Syndrome Type B Antigen 3 4
  • SS-B 3 4
  • La Ribonucleoprotein Domain Family, Member 3 3
  • La Ribonucleoprotein Domain Family 2
  • La Ribonucleoprotein 4
  • Lupus La Protein 2
  • Lupus La Antigen 3
  • SS-B/La Protein 3
  • Autoantigen La 3
  • Member 3 2
  • La/SSB 3
  • LARP3 3
  • La 3

External Ids for SSB Gene

Previous GeneCards Identifiers for SSB Gene

  • GC02P168707
  • GC02P169196
  • GC02P170619
  • GC02P170857
  • GC02P170480
  • GC02P170363
  • GC02P162543
  • GC02P170649

Summaries for SSB Gene

Entrez Gene Summary for SSB Gene

  • The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

GeneCards Summary for SSB Gene

SSB (Sjogren Syndrome Antigen B) is a Protein Coding gene. Diseases associated with SSB include Sjogren's Syndrome and Systemic Lupus Erythematosus. Among its related pathways are RNA Polymerase III Transcription Initiation and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for SSB Gene

  • Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Gene Wiki entry for SSB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSB Gene

Genomics for SSB Gene

Products:

  1. Regulatory Element

Regulatory Elements for SSB Gene

Enhancers for SSB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SSB on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SSB gene promoter:

Genomic Location for SSB Gene

Chromosome:
2
Start:
169,791,933 bp from pter
End:
169,812,064 bp from pter
Size:
20,132 bases
Orientation:
Plus strand

Genomic View for SSB Gene

Genes around SSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SSB Gene

Proteins for SSB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05455-LA_HUMAN
    Recommended name:
    Lupus La protein
    Protein Accession:
    P05455
    Secondary Accessions:
    • Q15367
    • Q53XJ4

    Protein attributes for SSB Gene

    Size:
    408 amino acids
    Molecular mass:
    46837 Da
    Quaternary structure:
    • Interacts with DDX15. May interact with RUFY1.
    Miscellaneous:
    • Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

    Three dimensional structures from OCA and Proteopedia for SSB Gene

neXtProt entry for SSB Gene

Proteomics data for SSB Gene at MOPED

Protein Expression for SSB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SSB Gene

  • Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
  • The N-terminus is blocked.
  • Ubiquitination at Lys 9, Lys 76, Lys 95, Lys 116, Lys 176, Lys 224, Lys 229, Lys 287, Lys 312, and Lys 328
  • Modification sites at PhosphoSitePlus

Other Protein References for SSB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SSB Gene

Domains & Families for SSB Gene

Gene Families for SSB Gene

HGNC:

Protein Domains for SSB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SSB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05455

UniProtKB/Swiss-Prot:

LA_HUMAN :
  • Contains 1 HTH La-type RNA-binding domain.
Domain:
  • Contains 1 HTH La-type RNA-binding domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SSB: view

Function for SSB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SSB Gene

UniProtKB/Swiss-Prot Function:
Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Gene Ontology (GO) - Molecular Function for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding TAS 10983981
GO:0000166 nucleotide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SSB: view

Phenotypes for SSB Gene

MGI mutant phenotypes for SSB:
inferred from 3 alleles
GenomeRNAi human phenotypes for SSB:
genes like me logo Genes that share phenotypes with SSB: view

Animal Models for SSB Gene

MGI Knock Outs for SSB:

Animal Model Products

miRNA for SSB Gene

miRTarBase miRNAs that target SSB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSB Gene

Localization for SSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSB Gene COMPARTMENTS Subcellular localization image for SSB gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SSB Gene

Pathways & Interactions for SSB Gene

genes like me logo Genes that share pathways with SSB: view

SIGNOR curated interactions for SSB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903608 protein localization to cytoplasmic stress granule IDA 24965446
genes like me logo Genes that share ontologies with SSB: view

Drugs & Compounds for SSB Gene

Products:

  1. Drug

(1) Drugs for SSB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SSB: view

Transcripts for SSB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SSB Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(308) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SSB Gene

Sjogren syndrome antigen B (autoantigen La):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSB Gene

No ASD Table

Relevant External Links for SSB Gene

GeneLoc Exon Structure for
SSB
ECgene alternative splicing isoforms for
SSB

Expression for SSB Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SSB Gene

mRNA expression in normal human tissues for SSB Gene
mRNA expression by BioGPS for SSB GenemRNA expression by GTEx for SSB Gene

Protein differential expression in normal tissues from HIPED for SSB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SSB Gene



SOURCE GeneReport for Unigene cluster for SSB Gene Hs.632535

genes like me logo Genes that share expression patterns with SSB: view

Protein tissue co-expression partners for SSB Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSB Gene

Orthologs for SSB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SSB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SSB 35
  • 92.41 (n)
  • 94.31 (a)
SSB 36
  • 94 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SSB 35
  • 92.76 (n)
  • 94.81 (a)
SSB 36
  • 94 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ssb 35
  • 85.63 (n)
  • 81.7 (a)
Ssb 16
Ssb 36
  • 78 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SSB 35
  • 99.84 (n)
  • 100 (a)
SSB 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ssb 35
  • 85.21 (n)
  • 82.21 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 77 (a)
 OneToMany
-- 36
  • 80 (a)
 OneToMany
-- 36
  • 80 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia SSB 36
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SSB 35
  • 75.66 (n)
  • 75.25 (a)
SSB 36
  • 74 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SSB 36
  • 67 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ssb 35
  • 67.08 (n)
  • 63.95 (a)
Str.2099 35
African clawed frog
(Xenopus laevis)
 Amphibia MGC52876 35
zebrafish
(Danio rerio)
 Actinopterygii ssb 35
  • 61.98 (n)
  • 57.29 (a)
wufb17f11 35
ssb 36
  • 56 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta La 37
  • 35 (a)
La 35
  • 47.97 (n)
  • 40.24 (a)
La 36
  • 31 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP008952 35
  • 46.85 (n)
  • 39.94 (a)
worm
(Caenorhabditis elegans)
 Secernentea C44E4.4 37
  • 35 (a)
C44E4.4 35
  • 47.08 (n)
  • 35.31 (a)
C44E4.4 36
  • 21 (a)
 OneToOne
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes LHP1 36
  • 20 (a)
 OneToMany
LHP1 38
Species with no ortholog for SSB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSB Gene

ENSEMBL:
Gene Tree for SSB (if available)
TreeFam:
Gene Tree for SSB (if available)

Paralogs for SSB Gene

(3) SIMAP similar genes for SSB Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for SSB Gene

genes like me logo Genes that share paralogs with SSB: view

No data available for Paralogs for SSB Gene

Variants for SSB Gene

Sequence variations from dbSNP and Humsavar for SSB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_034066 -
rs2857387 -- 169,806,199(+) ggctc(A/T)agtga intron-variant
rs2857388 -- 169,808,420(+) ATTCA(A/T)AATAA intron-variant
rs2857389 -- 169,809,347(+) CTGCA(C/G)TCCAG intron-variant
rs2857390 -- 169,809,826(+) TTAGC(C/T)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SSB Gene

Variant ID Type Subtype PubMed ID
nsv10201 CNV Loss 18304495
nsv3026 CNV Loss 18451855

Variation tolerance for SSB Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SSB Gene

Disorders for SSB Gene

MalaCards: The human disease database

(7) MalaCards diseases for SSB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
systemic lupus erythematosus
  • lupus nephritis
lupus erythematosus
  • systemic lupus erythematosus
undifferentiated connective tissue disease
  • uctd
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search SSB in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSB

Genetic Association Database (GAD)
SSB
Human Genome Epidemiology (HuGE) Navigator
SSB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSB
genes like me logo Genes that share disorders with SSB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSB Gene

Publications for SSB Gene

  1. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PMID: 2468131) Chan E.K.L. … Tan E.M. (Nucleic Acids Res. 1989) 2 3 4 67
  2. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. (PMID: 1692037) Kohsaka H. … Miyamoto T. (J. Clin. Invest. 1990) 2 3 23
  3. Differential phosphorylation and subcellular localization of La RNPs associated with precursor tRNAs and translation-related mRNAs. (PMID: 14636586) Intine R.V. … Maraia R.J. (Mol. Cell 2003) 3 23
  4. Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation. (PMID: 25520193) Kuehnert J. … Heise T. (Nucleic Acids Res. 2015) 3
  5. Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/SjAPgren's syndrome-B and human La-specific TCR. (PMID: 25582858) Yaciuk J.C. … Farris A.D. (J. Immunol. 2015) 3

Products for SSB Gene

  • Addgene plasmids for SSB

Sources for SSB Gene

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