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Aliases for SSB Gene

Aliases for SSB Gene

  • Sjogren Syndrome Antigen B 2 3 5
  • La Autoantigen 2 3 4
  • La Ribonucleoprotein Domain Family, Member 3 2 3
  • Sjoegren Syndrome Type B Antigen 3 4
  • Lupus La Protein 2 3
  • SS-B 3 4
  • Sjogren Syndrome Antigen B (Autoantigen La) 2
  • La Ribonucleoprotein 4
  • Lupus La Antigen 3
  • SS-B/La Protein 3
  • Autoantigen La 3
  • La/SSB 3
  • LARP3 3
  • La 3

External Ids for SSB Gene

Previous GeneCards Identifiers for SSB Gene

  • GC02P168707
  • GC02P169196
  • GC02P170619
  • GC02P170857
  • GC02P170480
  • GC02P170363
  • GC02P162543
  • GC02P170649

Summaries for SSB Gene

Entrez Gene Summary for SSB Gene

  • The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

GeneCards Summary for SSB Gene

SSB (Sjogren Syndrome Antigen B) is a Protein Coding gene. Diseases associated with SSB include Sjogren's Syndrome and Systemic Lupus Erythematosus. Among its related pathways are RNA Polymerase III Transcription Initiation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for SSB Gene

  • Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Gene Wiki entry for SSB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SSB Gene

Genomics for SSB Gene

Regulatory Elements for SSB Gene

Enhancers for SSB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F169732 1 ENCODE 16.2 -58.0 -58034 2.0 ATF1 CREB3L1 SIN3A ZNF48 GLIS2 ELK1 ZNF143 KLF13 SP5 JUNB SSB CYB5AP2 CCDC173 PHOSPHO2 GC02M169725 GC02P169749
GH02F169709 0.2 ENCODE 16.1 -80.4 -80385 4.1 ATF1 ELK1 GATA2 KLF13 CREB3 MEF2D SMARCA4 PBX2 ILK KLF1 PHOSPHO2 SSB CCDC173 CYB5AP2 METTL5 UBR3 KLHL23 GC02P169728
GH02F169703 1.1 ENCODE 15.6 -86.8 -86834 3.2 CEBPB ZNF18 ZNF558 PHOSPHO2 CCDC173 SSB CYB5AP2 KLHL23 GC02P169728
GH02F169528 0.4 ENCODE 11.4 -263.5 -263518 0.2 HDAC1 CTCF SAP130 WRNIP1 ARID4B ZNF2 RAD21 CHAMP1 ZKSCAN1 ZNF143 SSB CYB5AP2 METTL5 UBR3 FASTKD1 GC02M169527
GH02F169682 0.5 ENCODE 11.1 -108.6 -108561 1.7 MLX ARID4B DMAP1 YY1 SLC30A9 MXD4 PPARG KAT8 MIER3 ETV4 FASTKD1 PHOSPHO2 CYB5AP2 SSB GC02M169688 LOC100421474
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SSB on UCSC Golden Path with GeneCards custom track

Genomic Location for SSB Gene

Chromosome:
2
Start:
169,791,933 bp from pter
End:
169,812,064 bp from pter
Size:
20,132 bases
Orientation:
Plus strand

Genomic View for SSB Gene

Genes around SSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SSB Gene

Proteins for SSB Gene

  • Protein details for SSB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05455-LA_HUMAN
    Recommended name:
    Lupus La protein
    Protein Accession:
    P05455
    Secondary Accessions:
    • Q15367
    • Q53XJ4

    Protein attributes for SSB Gene

    Size:
    408 amino acids
    Molecular mass:
    46837 Da
    Quaternary structure:
    • Interacts with DDX15. May interact with RUFY1.
    Miscellaneous:
    • Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

    Three dimensional structures from OCA and Proteopedia for SSB Gene

neXtProt entry for SSB Gene

Post-translational modifications for SSB Gene

  • Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.
  • The N-terminus is blocked.
  • Ubiquitination at Lys 9, Lys 76, Lys 95, Lys 116, Lys 176, Lys 224, Lys 229, Lys 287, Lys 312, and Lys 328
  • Modification sites at PhosphoSitePlus

Other Protein References for SSB Gene

No data available for DME Specific Peptides for SSB Gene

Domains & Families for SSB Gene

Suggested Antigen Peptide Sequences for SSB Gene

Graphical View of Domain Structure for InterPro Entry

P05455

UniProtKB/Swiss-Prot:

LA_HUMAN :
  • Contains 1 HTH La-type RNA-binding domain.
Domain:
  • Contains 1 HTH La-type RNA-binding domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with SSB: view

Function for SSB Gene

Molecular function for SSB Gene

UniProtKB/Swiss-Prot Function:
Binds to the 3 poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Gene Ontology (GO) - Molecular Function for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding TAS 10983981
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding TAS 9154801
genes like me logo Genes that share ontologies with SSB: view
genes like me logo Genes that share phenotypes with SSB: view

Animal Models for SSB Gene

MGI Knock Outs for SSB:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSB

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SSB Gene

Localization for SSB Gene

Subcellular locations from UniProtKB/Swiss-Prot for SSB Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SSB Gene COMPARTMENTS Subcellular localization image for SSB gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0005634 nucleus IEA,IDA 24965446
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with SSB: view

Pathways & Interactions for SSB Gene

genes like me logo Genes that share pathways with SSB: view

SIGNOR curated interactions for SSB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SSB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0006400 tRNA modification TAS 10983981
GO:0008334 histone mRNA metabolic process TAS 9154801
GO:0075522 IRES-dependent viral translational initiation IDA 12384597
GO:1903608 protein localization to cytoplasmic stress granule IDA 24965446
genes like me logo Genes that share ontologies with SSB: view

Drugs & Compounds for SSB Gene

(1) Drugs for SSB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SSB: view

Transcripts for SSB Gene

Unigene Clusters for SSB Gene

Sjogren syndrome antigen B (autoantigen La):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SSB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SSB Gene

No ASD Table

Relevant External Links for SSB Gene

GeneLoc Exon Structure for
SSB
ECgene alternative splicing isoforms for
SSB

Expression for SSB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SSB Gene

Protein differential expression in normal tissues from HIPED for SSB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SSB Gene



Protein tissue co-expression partners for SSB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SSB Gene:

SSB

SOURCE GeneReport for Unigene cluster for SSB Gene:

Hs.632535
genes like me logo Genes that share expression patterns with SSB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SSB Gene

Orthologs for SSB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SSB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SSB 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia SSB 34 35
  • 92.76 (n)
cow
(Bos Taurus)
Mammalia SSB 34 35
  • 92.41 (n)
mouse
(Mus musculus)
Mammalia Ssb 34 16 35
  • 85.63 (n)
rat
(Rattus norvegicus)
Mammalia Ssb 34
  • 85.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SSB 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves SSB 34 35
  • 75.66 (n)
lizard
(Anolis carolinensis)
Reptilia SSB 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ssb 34
  • 67.08 (n)
Str.2099 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52876 34
zebrafish
(Danio rerio)
Actinopterygii ssb 34 35
  • 61.98 (n)
wufb17f11 34
fruit fly
(Drosophila melanogaster)
Insecta La 36 34 35
  • 47.97 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008952 34
  • 46.85 (n)
worm
(Caenorhabditis elegans)
Secernentea C44E4.4 36 34 35
  • 47.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LHP1 35 37
  • 20 (a)
OneToMany
Species where no ortholog for SSB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SSB Gene

ENSEMBL:
Gene Tree for SSB (if available)
TreeFam:
Gene Tree for SSB (if available)

Paralogs for SSB Gene

(3) SIMAP similar genes for SSB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SSB: view

No data available for Paralogs for SSB Gene

Variants for SSB Gene

Sequence variations from dbSNP and Humsavar for SSB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10188178 -- 169,810,149(+) tgccc(C/T)ggcgg intron-variant
rs1051387 -- 169,811,845(+) GGTCC(A/C)CTTCA reference, missense, utr-variant-3-prime
rs1051392 -- 169,811,857(+) TGTCC(A/C)CCTGT reference, missense, utr-variant-3-prime
rs1051408 -- 169,811,898(+) TTGTC(C/T)TTTTG intron-variant, utr-variant-3-prime
rs1051448 -- 169,806,893(+) TTAAG(G/T)TATGA splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for SSB Gene

Variant ID Type Subtype PubMed ID
nsv1011368 CNV loss 25217958
nsv10201 CNV loss 18304495
nsv3026 CNV deletion 18451855
nsv583606 CNV loss 21841781
nsv583607 CNV gain 21841781
nsv583608 CNV gain 21841781
nsv961527 CNV duplication 23825009

Variation tolerance for SSB Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SSB Gene

Disorders for SSB Gene

MalaCards: The human disease database

(10) MalaCards diseases for SSB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sjogren's syndrome
  • sicca syndrome
systemic lupus erythematosus
  • lupus nephritis
lupus erythematosus
  • lupus
undifferentiated connective tissue disease
  • uctd
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards
Search SSB in MalaCards View complete list of genes associated with diseases

Relevant External Links for SSB

Genetic Association Database (GAD)
SSB
Human Genome Epidemiology (HuGE) Navigator
SSB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SSB
genes like me logo Genes that share disorders with SSB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SSB Gene

Publications for SSB Gene

  1. Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein. (PMID: 1692037) Kohsaka H. … Miyamoto T. (J. Clin. Invest. 1990) 2 3 22 64
  2. Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding. (PMID: 2468131) Chan E.K.L. … Tan E.M. (Nucleic Acids Res. 1989) 2 3 4 64
  3. Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein. (PMID: 18547518) Kotik-Kogan O. … Curry S. (Structure 2008) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Structural basis for recognition and sequestration of UUU(OH) 3' termini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen. (PMID: 16387655) Teplova M. … Patel D.J. (Mol. Cell 2006) 3 4 64

Products for SSB Gene

Sources for SSB Gene

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