Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SS18L2 Gene

Aliases for SS18L2 Gene

  • SS18 Like 2 2 3 5
  • SYT Homolog 2 2 3 4
  • Synovial Sarcoma Translocation Gene On Chromosome 18-Like 2 2 3
  • SS18-Like Protein 2 3
  • KIAA-Iso 3

External Ids for SS18L2 Gene

Previous GeneCards Identifiers for SS18L2 Gene

  • GC03P041937
  • GC03P041812
  • GC03P042442
  • GC03P042592
  • GC03P042569

Summaries for SS18L2 Gene

Entrez Gene Summary for SS18L2 Gene

  • Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]

GeneCards Summary for SS18L2 Gene

SS18L2 (SS18 Like 2) is a Protein Coding gene. An important paralog of this gene is SS18L1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SS18L2 Gene

Genomics for SS18L2 Gene

Regulatory Elements for SS18L2 Gene

Enhancers for SS18L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F042501 1.5 FANTOM5 Ensembl ENCODE 10.8 -74.8 -74756 10.6 ATF1 PKNOX1 SIN3A YY1 ZNF143 FOS SP3 NFYC MIER2 REST SEC22C VIPR1-AS1 SS18L2 NKTR CCDC13-AS1 VIPR1
GH03F042610 1.3 Ensembl ENCODE 11.9 +30.3 30278 2.7 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 GLIS2 ZNF143 KLF7 FOS NKTR SEC22C SS18L2 ZBTB47
GH03F042539 1.2 Ensembl ENCODE 12 -41.8 -41840 0.8 ATF1 SIN3A ZNF48 ZNF143 KLF13 SP3 ZHX2 KAT8 MBD2 MXD3 NKTR SS18L2 SEC22C VIPR1 CCDC13 CCDC13-AS1 VIPR1-AS1
GH03F042650 1.3 FANTOM5 ENCODE 10.6 +72.0 71989 6.4 HDGF PKNOX1 ZFP64 SIN3A DMAP1 ZNF121 GLIS2 KLF7 FOS SP3 SEC22C NKTR SS18L2 HHATL FAM198A LOC101928323 ZBTB47
GH03F042544 0.9 Ensembl ENCODE 12.1 -36.7 -36682 1.3 SOX13 GATAD2A CTCF ELF3 NFIA FOXA3 NR3C1 REST HHEX NR2F2 SEC22C NKTR SS18L2 VIPR1 CCDC13 CCDC13-AS1 VIPR1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SS18L2 on UCSC Golden Path with GeneCards custom track

Promoters for SS18L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001362098 60 2201 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the SS18L2 gene promoter:

Genomic Location for SS18L2 Gene

Chromosome:
3
Start:
42,581,840 bp from pter
End:
42,595,114 bp from pter
Size:
13,275 bases
Orientation:
Plus strand

Genomic View for SS18L2 Gene

Genes around SS18L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SS18L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SS18L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SS18L2 Gene

Proteins for SS18L2 Gene

  • Protein details for SS18L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHA2-S18L2_HUMAN
    Recommended name:
    SS18-like protein 2
    Protein Accession:
    Q9UHA2
    Secondary Accessions:
    • B2R5L1

    Protein attributes for SS18L2 Gene

    Size:
    77 amino acids
    Molecular mass:
    8835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SS18L2 Gene

Post-translational modifications for SS18L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SS18L2 Gene

No data available for DME Specific Peptides for SS18L2 Gene

Domains & Families for SS18L2 Gene

Protein Domains for SS18L2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SS18L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UHA2

UniProtKB/Swiss-Prot:

S18L2_HUMAN :
  • Belongs to the SS18 family.
Family:
  • Belongs to the SS18 family.
genes like me logo Genes that share domains with SS18L2: view

No data available for Gene Families for SS18L2 Gene

Function for SS18L2 Gene

genes like me logo Genes that share phenotypes with SS18L2: view

Animal Model Products

miRNA for SS18L2 Gene

miRTarBase miRNAs that target SS18L2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SS18L2 Gene

Localization for SS18L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SS18L2 gene
Compartment Confidence
extracellular 3
nucleus 3
mitochondrion 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SS18L2 Gene

Pathways & Interactions for SS18L2 Gene

SuperPathways for SS18L2 Gene

No Data Available

Interacting Proteins for SS18L2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000011691%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000411532%0d%0a9606.ENSP00000396704%0d%0a9606.ENSP00000396704%0d%0a9606.ENSP00000309503%0d%0a
Selected Interacting proteins: Q9UHA2-S18L2_HUMAN ENSP00000011691 for SS18L2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for SS18L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SS18L2 Gene

Transcripts for SS18L2 Gene

mRNA/cDNA for SS18L2 Gene

Unigene Clusters for SS18L2 Gene

Synovial sarcoma translocation gene on chromosome 18-like 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SS18L2 Gene

No ASD Table

Relevant External Links for SS18L2 Gene

GeneLoc Exon Structure for
SS18L2
ECgene alternative splicing isoforms for
SS18L2

Expression for SS18L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SS18L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SS18L2 Gene

This gene is overexpressed in Lung (55.0) and CD8 Tcells (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SS18L2 Gene



Protein tissue co-expression partners for SS18L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SS18L2 Gene:

SS18L2

SOURCE GeneReport for Unigene cluster for SS18L2 Gene:

Hs.534454
genes like me logo Genes that share expression patterns with SS18L2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SS18L2 Gene

Orthologs for SS18L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SS18L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SS18L2 34
  • 91.34 (n)
dog
(Canis familiaris)
Mammalia SS18L2 34 35
  • 90.91 (n)
chimpanzee
(Pan troglodytes)
Mammalia SS18L2 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Deb1 34 16 35
  • 83.98 (n)
rat
(Rattus norvegicus)
Mammalia LOC687029 34
  • 83.55 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SS18L2 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SS18L2 35
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves SS18L2 34 35
  • 79.22 (n)
lizard
(Anolis carolinensis)
Reptilia SS18L2 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ss18l2 34
  • 70.37 (n)
Str.7278 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13215 34
zebrafish
(Danio rerio)
Actinopterygii ss18l2 34 35
  • 69.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10555 35
  • 1 (a)
OneToMany
Species where no ortholog for SS18L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SS18L2 Gene

ENSEMBL:
Gene Tree for SS18L2 (if available)
TreeFam:
Gene Tree for SS18L2 (if available)

Paralogs for SS18L2 Gene

Paralogs for SS18L2 Gene

(5) SIMAP similar genes for SS18L2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SS18L2 Gene

genes like me logo Genes that share paralogs with SS18L2: view

Variants for SS18L2 Gene

Sequence variations from dbSNP and Humsavar for SS18L2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs112351303 -- 42,584,121(+) CATAT(A/T)TCTAT intron-variant, upstream-variant-2KB
rs112440650 -- 42,584,956(+) ACCCC(A/G)TCTCT intron-variant
rs113405209 -- 42,581,738(+) GGCCG(G/T)GTGGG intron-variant, upstream-variant-2KB
rs114185497 -- 42,586,957(+) AGTTG(C/T)TTAAC intron-variant
rs114346139 -- 42,582,700(+) AGGGG(A/T)TTTGG intron-variant, upstream-variant-2KB

Variation tolerance for SS18L2 Gene

Residual Variation Intolerance Score: 42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SS18L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SS18L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SS18L2 Gene

Disorders for SS18L2 Gene

Relevant External Links for SS18L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SS18L2

No disorders were found for SS18L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SS18L2 Gene

Publications for SS18L2 Gene

  1. Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene. (PMID: 11435705) de Bruijn D.R. … Geurts Van Kessel A. (Cytogenet. Cell Genet. 2001) 2 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. (PMID: 16484776) de Bruijn D.R. … Geurts van Kessel A. (Cytogenet. Genome Res. 2006) 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for SS18L2 Gene

Sources for SS18L2 Gene

Content
Loading form....