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Aliases for SS18L2 Gene

Aliases for SS18L2 Gene

  • Synovial Sarcoma Translocation Gene On Chromosome 18-Like 2 2 3
  • SYT Homolog 2 2 3 4
  • SS18-Like Protein 2 3
  • KIAA-Iso 3

External Ids for SS18L2 Gene

Previous GeneCards Identifiers for SS18L2 Gene

  • GC03P041937
  • GC03P041812
  • GC03P042442
  • GC03P042592
  • GC03P042569

Summaries for SS18L2 Gene

Entrez Gene Summary for SS18L2 Gene

  • Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]

GeneCards Summary for SS18L2 Gene

SS18L2 (Synovial Sarcoma Translocation Gene On Chromosome 18-Like 2) is a Protein Coding gene. An important paralog of this gene is SS18.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SS18L2 Gene

Genomics for SS18L2 Gene

Regulatory Elements for SS18L2 Gene

Transcription factor binding sites by QIAGEN in the SS18L2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SS18L2 Gene

42,581,840 bp from pter
42,595,114 bp from pter
13,275 bases
Plus strand

Genomic View for SS18L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SS18L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SS18L2 Gene

Proteins for SS18L2 Gene

  • Protein details for SS18L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SS18-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R5L1

    Protein attributes for SS18L2 Gene

    77 amino acids
    Molecular mass:
    8835 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SS18L2 Gene

Proteomics data for SS18L2 Gene at MOPED

Post-translational modifications for SS18L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SS18L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SS18L2 Gene

Domains for SS18L2 Gene

Protein Domains for SS18L2 Gene


Suggested Antigen Peptide Sequences for SS18L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SS18 family.
  • Belongs to the SS18 family.
genes like me logo Genes that share domains with SS18L2: view

No data available for Gene Families for SS18L2 Gene

Function for SS18L2 Gene

genes like me logo Genes that share phenotypes with SS18L2: view

Animal Model Products

CRISPR Products

miRNA for SS18L2 Gene

miRTarBase miRNAs that target SS18L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SS18L2 Gene

Localization for SS18L2 Gene

Subcellular locations from

Jensen Localization Image for SS18L2 Gene COMPARTMENTS Subcellular localization image for SS18L2 gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SS18L2 Gene

Pathways for SS18L2 Gene

SuperPathways for SS18L2 Gene

No Data Available

Interacting Proteins for SS18L2 Gene

Gene Ontology (GO) - Biological Process for SS18L2 Gene


No data available for Pathways by source for SS18L2 Gene

Transcripts for SS18L2 Gene

mRNA/cDNA for SS18L2 Gene

Unigene Clusters for SS18L2 Gene

Synovial sarcoma translocation gene on chromosome 18-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SS18L2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SS18L2 Gene

No ASD Table

Relevant External Links for SS18L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SS18L2 Gene

mRNA expression in normal human tissues for SS18L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SS18L2 Gene

This gene is overexpressed in Lung (55.0) and CD8 Tcells (14.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SS18L2 Gene

SOURCE GeneReport for Unigene cluster for SS18L2 Gene Hs.534454

genes like me logo Genes that share expressions with SS18L2: view

Expression partners for SS18L2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SS18L2 Gene

Orthologs for SS18L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SS18L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SS18L2 35
  • 91.34 (n)
  • 96.1 (a)
(Canis familiaris)
Mammalia SS18L2 35
  • 90.91 (n)
  • 94.81 (a)
SS18L2 36
  • 95 (a)
(Mus musculus)
Mammalia Deb1 35
  • 83.98 (n)
  • 87.01 (a)
Deb1 16
Deb1 36
  • 87 (a)
(Rattus norvegicus)
Mammalia LOC687029 35
  • 83.55 (n)
  • 87.01 (a)
(Monodelphis domestica)
Mammalia SS18L2 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia SS18L2 36
  • 69 (a)
(Pan troglodytes)
Mammalia SS18L2 36
  • 90 (a)
(Gallus gallus)
Aves SS18L2 35
  • 79.22 (n)
  • 80.52 (a)
SS18L2 36
  • 81 (a)
(Anolis carolinensis)
Reptilia SS18L2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ss18l2 35
  • 70.37 (n)
  • 70.83 (a)
Str.7278 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13215 35
(Danio rerio)
Actinopterygii ss18l2 35
  • 69.12 (n)
  • 75 (a)
ss18l2 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10555 36
  • 1 (a)
Species with no ortholog for SS18L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SS18L2 Gene

Gene Tree for SS18L2 (if available)
Gene Tree for SS18L2 (if available)

Paralogs for SS18L2 Gene

Paralogs for SS18L2 Gene

(5) SIMAP similar genes for SS18L2 Gene using alignment to 1 proteins: Pseudogenes for SS18L2 Gene

genes like me logo Genes that share paralogs with SS18L2: view

Variants for SS18L2 Gene

Relevant External Links for SS18L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for SS18L2 Gene

Disorders for SS18L2 Gene

(1) University of Copenhagen DISEASES for SS18L2 Gene

genes like me logo Genes that share disorders with SS18L2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for SS18L2 Gene

Publications for SS18L2 Gene

  1. Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene. (PMID: 11435705) de Bruijn D.R. … Geurts Van Kessel A. (Cytogenet. Cell Genet. 2001) 2 3 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for SS18L2 Gene

Sources for SS18L2 Gene

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