Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SS18L1 Gene

protein-coding   GIFtS: 54
GCID: GC20P060718

Synovial Sarcoma Translocation Gene On Chromosome 18-Like...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Synovial Sarcoma Translocation Gene On Chromosome 18-Like 11 2     KIAA06933 5
CREST2 3 5     LP22612
SS18-Like Protein 12 3     Calcium-Responsive Transactivator2
SYT Homolog 12 3     

External Ids:    HGNC: 155921   Entrez Gene: 260392   Ensembl: ENSG000001844027   OMIM: 6064725   UniProtKB: O751773   

Export aliases for SS18L1 gene to outside databases

Previous GC identifers: GC20P060482 GC20P061357 GC20P061404 GC20P060152 GC20P057510


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SS18L1 Gene:
Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a
recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene
(MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM
300326) gene. The SS18L1 gene is homologous to SS18.(supplied by OMIM, Jul 2002)

GeneCards Summary for SS18L1 Gene: 
SS18L1 (synovial sarcoma translocation gene on chromosome 18-like 1) is a protein-coding gene. Diseases associated with SS18L1 include synovial sarcoma, and sarcoma. An important paralog of this gene is SS18.

UniProtKB/Swiss-Prot: CREST_HUMAN, O75177
Function: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in
cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex,
a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a
repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS
promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium
influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same
time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to
transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent
induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity)

Gene Wiki entry for SS18L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SS18L1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SS18L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SS18L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.3

SS18L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SS18L1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P060718:  view genomic region     (about GC identifiers)

Start:
60,718,822 bp from pter      End:
60,757,566 bp from pter
Size:
38,745 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CREST_HUMAN, O75177 (See protein sequence)
Recommended Name: Calcium-responsive transactivator  
Size: 396 amino acids; 42990 Da
Subunit: Homodimer. Dimerization may be necessary for its function in neuronal dendritic development. Interacts
(via C-terminus) with CREBBP (via N-terminus), EP300 and SMARCA4/BRG1. Interacts with the nBAF complex.
Association with CREBBP facilitates transcription while the association with SMARCA4/BRG1 suppresses
CREST-mediated transcription in resting neurons (By similarity)
Subcellular location: Nucleus (By similarity). Chromosome, centromere, kinetochore (By similarity). Note=Localizes
to nuclear bodies. Co-localizes with SGOL1 at kinetochore (By similarity)
Sequence caution: Sequence=BAA31668.1; Type=Erroneous initiation;
Secondary accessions: A6NNE3 A8K620 B3KWR8 E1P5H7 Q5JXJ3 Q6MZV9 Q6NTH3 Q6XYD9 Q8NE69 Q9BR55
Q9H4K6
Alternative splicing: 5 isoforms:  O75177-1   O75177-2   O75177-3   O75177-4   O75177-5   

Explore the universe of human proteins at neXtProt for SS18L1: NX_O75177

Explore proteomics data for SS18L1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75177

  • SS18L1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SS18L1 Protein Expression
    REFSEQ proteins: NP_945173.1  
    ENSEMBL proteins: 
     ENSP00000398634   ENSP00000333012   ENSP00000434451   ENSP00000393999   ENSP00000359885  

    Human Recombinant Protein Products for SS18L1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SS18L1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SS18L1
    GenScript Custom Purified and Recombinant Proteins Services for SS18L1
    Novus Biologicals SS18L1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SS18L1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000780condensed nuclear chromosome, centromeric region IEA--
    GO:0005634nucleus ISS--
    GO:0016604nuclear body IEA--

    SS18L1 for ontologies           About GeneDecksing



    SS18L1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SS18L1
    GenScript Custom Superior Antibodies Services for SS18L1
    Novus Biologicals SS18L1 Antibodies
    Abcam antibodies for SS18L1
    Cloud-Clone Corp. Antibodies for SS18L1 
    ThermoFisher Antibody for SS18L1
    LSBio Antibodies in human, mouse, rat for SS18L1 

    Assay Products for SS18L1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SS18L1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SS18L1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SS18L1 
    Cloud-Clone Corp. CLIAs for SS18L1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007726 SSXT

    Graphical View of Domain Structure for InterPro Entry O75177

    ProtoNet protein and cluster: O75177

    2 Blocks protein domains:
    IPB000532 Glucagon/GIP/secretin/VIP
    IPB007726 SSXT


    UniProtKB/Swiss-Prot: CREST_HUMAN, O75177
    Domain: The MFD (multi-functional domain) domain is involved in transcription transactivation, nuclear body
    targeting and dimerization (By similarity)
    Similarity: Belongs to the SS18 family


    SS18L1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CREST_HUMAN, O75177
    Function: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in
    cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex,
    a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a
    repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS
    promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium
    influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same
    time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to
    transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent
    induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SS18L1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SS18L1:
     Decreased Wnt reporter activit 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ss18l1):
     behavior/neurological  growth/size  mortality/aging  nervous system  reproductive system 

    SS18L1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ss18l1tm1Ghsh for SS18L1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SS18L1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SS18L1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SS18L1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SS18L1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SS18L1
    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate SS18L1 (see all 77):
    hsa-miR-520e hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-128 hsa-miR-938 hsa-miR-10b* hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SS18L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SS18L1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SS18L1
    Sirion Biotech Customized adenovirus for overexpression of SS18L1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SS18L1 (see all 6)
    OriGene ORF clones in mouse, rat for SS18L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SS18L1 (NM_198935)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SS18L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SS18L1
    Sirion Biotech Customized lentivirus for stable overexpression of SS18L1 
                         Customized lentivirus expression plasmids for stable overexpression of SS18L1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SS18L1
    Search LifeMap BioReagents cell lines for SS18L1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SS18L1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SS18L1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for SS18L1 (O751773 ENSP000003330124) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMARCA4P515323, ENSP000003507204I2D: score=2 STRING: ENSP00000350720
    AATFQ9NY613, ENSP000002254024I2D: score=1 STRING: ENSP00000225402
    ELF5Q9UKW63, ENSP000003110104I2D: score=1 STRING: ENSP00000311010
    HDAC4P565243, ENSP000002646064I2D: score=1 STRING: ENSP00000264606
    MED30Q96HR33, ENSP000002973474I2D: score=1 STRING: ENSP00000297347
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016358dendrite development IEA--
    GO:0016568chromatin modification IEA--
    GO:0045893positive regulation of transcription, DNA-dependent ISS--
    GO:0050773regulation of dendrite development IEA--

    SS18L1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SS18L1 (CREST)

    Search CenterWatch for drugs/clinical trials and news about SS18L1 / CREST

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SS18L1 gene (2 alternative transcripts): 
    NM_015558.3  NM_198935.1  

    Unigene Cluster for SS18L1:

    Synovial sarcoma translocation gene on chromosome 18-like 1
    Hs.154429  [show with all ESTs]
    Unigene Representative Sequence: NM_198935
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450482 ENST00000331758(uc002ycb.3) ENST00000491916 ENST00000492466
    ENST00000421564(uc011aaa.1 uc002ybz.1 uc002yca.1) ENST00000370848(uc002ycc.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SS18L1
    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate SS18L1 (see all 77):
    hsa-miR-520e hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-128 hsa-miR-938 hsa-miR-10b* hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SS18L1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SS18L1
    Clone
    Products:
         
    OriGene clones in human, mouse for SS18L1 (see all 6)
    OriGene ORF clones in mouse, rat for SS18L1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SS18L1 (NM_198935)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SS18L1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SS18L1
    Sirion Biotech Customized lentivirus for stable overexpression of SS18L1 
                         Customized lentivirus expression plasmids for stable overexpression of SS18L1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SS18L1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SS18L1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SS18L1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SS18L1

    Additional mRNA sequence: 

    AB014593.1 AK125656.1 AK291485.1 AK299881.1 AK308765.1 

    7 DOTS entries:

    DT.100639850  DT.102836174  DT.91997047  DT.101981474  DT.91650539  DT.120813157  DT.120813153 

    24/73 AceView cDNA sequences (see all 73):

    BX483299 BU676187 AB014593 BC068993 AW952446 AY203931 NM_015558 AA488223 
    H01063 AA488199 AA488169 BG150091 BQ025990 NM_198935 BM452970 BU176753 
    T52987 BC034494 AW152517 AI566665 BQ722557 BE394633 BF940285 BP871682 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SS18L1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
    SP1:              -     -           -           -                                                               
    SP2:                                                                                                            
    SP3:                    -           -           -                                                               
    SP4:              -                 -           -                                                               
    SP5:                    -                                                                                       


    ECgene alternative splicing isoforms for SS18L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SS18L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SS18L1 Expression
    About this image


    See SS18L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SS18L1

    SOURCE GeneReport for Unigene cluster: Hs.154429

    UniProtKB/Swiss-Prot: CREST_HUMAN, O75177
    Tissue specificity: Ubiquitous; with lowest levels in spleen

        SABiosciences Custom PCR Arrays for SS18L1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SS18L1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SS18L1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SS18L1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SS18L1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SS18L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SS18L1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ss18l11 , 5 synovial sarcoma translocation gene on chromosome 18-like more1, 5 88.22(n)1
    91.16(a)1
      2 (102.56 cM)5
    2693971  NM_178750.51  NP_848865.41 
     1800425095 
    chicken
    (Gallus gallus)
    Aves SS18L11 synovial sarcoma translocation gene on chromosome 18-like more 77.02(n)
    87.37(a)
      419225  XM_417402.3  XP_417402.3 
    lizard
    (Anolis carolinensis)
    Reptilia SS18L16
    synovial sarcoma translocation gene on chromosome ...
    77(a)
    1 ↔ 1
    4(150639597-150668520)


    ENSEMBL Gene Tree for SS18L1 (if available)
    TreeFam Gene Tree for SS18L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SS18L1 gene
    SS182  SS18L22  
    5 SIMAP similar genes for SS18L1 using alignment to 3 protein entries:     CREST_HUMAN (see all proteins):
    SS18L2    SYT    SS18    SYT-SSX1    SYT-SSX2

    SS18L1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SS18L1
    PGOHUM00000248341


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1181 SNPs in SS18L1 are shown (see all 1181)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1879586721,2
    --60720526(+) ACCCAG/TAGCAT 1 -- int10--------
    rs1912003651,2
    --60720619(+) CACTTC/TGCACA 1 -- int10--------
    rs37612231,2
    C,F,A--60720646(+) CCCCAA/GATTCT 1 -- int112Minor allele frequency- N:0.01EA NA WA 576
    rs37612241,2
    C,F--60720668(+) TGTGTA/GTTGAG 1 -- int12Minor allele frequency- G:0.07WA EA 238
    rs37612251,2
    C,F,A--60720682(+) CTGCCG/CCGAAC 1 -- int18Minor allele frequency- C:0.41NA WA EA 368
    rs1478648451,2
    C--60720815(+) GTCTGC/TGTATT 1 -- int10--------
    rs1398929691,2
    C--60720830(+) TTGGTA/GTTTTG 1 -- int10--------
    rs1156072621,2
    C,F--60720848(+) ATATAT/CGTACC 1 -- int11Minor allele frequency- C:0.01WA 118
    rs72715051,2
    C,F,H--60720964(+) ATGCCG/AAGAGC 1 -- int18Minor allele frequency- A:0.01NS EA NA WA 822
    rs1825260831,2
    --60721036(+) AACTTA/GTCCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SS18L1 (60718822 - 60757566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for SS18L1 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722777CNV Deletion23290073
    esv271804CNV Insertion20981092
    nsv509782CNV Insertion20534489
    nsv3440CNV Insertion18451855
    dgv4598n71CNV Loss21882294
    nsv913040CNV Loss21882294
    dgv4597n71CNV Loss21882294
    nsv913034CNV Loss21882294
    dgv4599n71CNV Loss21882294
    dgv4600n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing SS18L1:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing SS18L1
    DNA2.0 Custom Variant and Variant Library Synthesis for SS18L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606472    OMIM disorders: --

    4 diseases for SS18L1:    About MalaCards
    synovial sarcoma    sarcoma    kidney disease    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SS18L1:
    Synovial sarcoma

    SS18L1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SS18L1
    Human Genome Epidemiology (HuGE) Navigator: SS18L1 (3 documents)

    Export disorders for SS18L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SS18L1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SS18L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    2. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PubMed id 19724895)1, 4 Yoshida T....Yamada Y. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
    7. Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. (PubMed id 16484776)1, 9 de Bruijn D.R. and Geurts van Kessel A. (2006)
    8. A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. (PubMed id 12696068)1, 9 Storlazzi C.T....Panagopoulos I. (2003)
    9. Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene. (PubMed id 11435705)1, 9 de Bruijn D.R....Geurts Van Kessel A. (2001)
    10. Exome sequencing to identify de novo mutations in spor adic ALS trios. (PubMed id 23708140)1 Chesi A....Gitler A.D. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26039 HGNC: 15592 AceView: SS18L1 Ensembl:ENSG00000184402 euGenes: HUgn26039
    ECgene: SS18L1 H-InvDB: SS18L1

    (According to HUGE)
    About This Section
    HUGE: KIAA0693

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SS18L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SS18L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SS18L1 gene:
    Search GeneIP for patents involving SS18L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SS18L1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SS18L1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SS18L1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SS18L1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SS18L1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SS18L1   OriGene Custom Protein Services for SS18L1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SS18L1
     QIAGEN SeqTarget long-range PCR primers for resequencing SS18L1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SS18L1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SS18L1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SS18L1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SS18L1
     GenScript Custom Purified and Recombinant Proteins Services for SS18L1 GenScript cDNA clones with any tag delivered in your preferred vector for SS18L1
     GenScript Custom Assay Services for SS18L1 GenScript Custom Superior Antibodies Services for SS18L1
     GenScript Custom overexpressing Cell Line Services for SS18L1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SS18L1 promoter
     Search Chromatin IP Primers for SS18L1
     RT2 qPCR Primer Assay in human, mouse, rat SS18L1
     Search GNC Networks for SS18L1
     SABiosciences Custom PCR Arrays for SS18L1
     Search Tocris compounds for SS18L1 (CREST)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SS18L1 antibodies
     SS18L1 proteins
     Antibodies for SS18L1
     See all of Abcam's Antibodies, Kits and Proteins for SS18L1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SS18L1
     Antibodies for SS18L1
     ELISAs for SS18L1
     CLIAs for SS18L1
     Search LifeMap BioReagents cell lines for SS18L1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SS18L1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SS18L1
     Browse SwitchGear Promoter luciferase reporter plasmids for SS18L1
     ThermoFisher Antibody for SS18L1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SS18L1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SS18L1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SS18L1
    Customized:
     lentivirus for stable overexpression of SS18L1
     lentivirus expression plasmids for stable overexpression of SS18L1
     adenovirus for overexpression of SS18L1
     LSBio Antibodies in human, mouse, rat for SS18L1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SS18L1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4