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Aliases for SS18 Gene

Aliases for SS18 Gene

  • Synovial Sarcoma Translocation, Chromosome 18 2 3
  • SSXT 3 4 6
  • SYT 3 4 6
  • Synovial Sarcoma Translocated To X Chromosome Protein 3 4
  • Synovial Sarcoma, Translocated To X Chromosome 3
  • Protein SSXT 3
  • Protein SYT 4

External Ids for SS18 Gene

Previous Symbols for SS18 Gene

  • SSXT

Summaries for SS18 Gene

GeneCards Summary for SS18 Gene

SS18 (Synovial Sarcoma Translocation, Chromosome 18) is a Protein Coding gene. Diseases associated with SS18 include colorado tick fever and sarcoma, synovial. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is SS18L2.

UniProtKB/Swiss-Prot for SS18 Gene

  • Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.

Gene Wiki entry for SS18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SS18 Gene

Genomics for SS18 Gene

Genomic Location for SS18 Gene

Start:
26,016,253 bp from pter
End:
26,091,217 bp from pter
Size:
74,965 bases
Orientation:
Minus strand

Genomic View for SS18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SS18 Gene

Regulatory Elements for SS18 Gene

Proteins for SS18 Gene

  • Protein details for SS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15532-SSXT_HUMAN
    Recommended name:
    Protein SSXT
    Protein Accession:
    Q15532
    Secondary Accessions:
    • B0YJ95
    • Q16404
    • Q4VAX1
    • Q9BXC6

    Protein attributes for SS18 Gene

    Size:
    418 amino acids
    Molecular mass:
    45929 Da
    Quaternary structure:
    • Interacts with MLLT10. Isoform 1 interacts with RBM14 isoform 1. Isoform 2 interacts with RBM14 isoform 1.
    SequenceCaution:
    • Sequence=AAK21314.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA55792.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SS18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SS18 Gene

Proteomics data for SS18 Gene at MOPED

Post-translational modifications for SS18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SS18 Gene

Domains for SS18 Gene

Protein Domains for SS18 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SSXT_HUMAN
Family:
  • Belongs to the SS18 family.:
    • Q15532
genes like me logo Genes that share domains with SS18: view

No data available for Gene Families for SS18 Gene

Function for SS18 Gene

Molecular function for SS18 Gene

UniProtKB/Swiss-Prot Function: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.

Gene Ontology (GO) - Molecular Function for SS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15919756
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 15919756
genes like me logo Genes that share ontologies with SS18: view
genes like me logo Genes that share phenotypes with SS18: view

Animal Models for SS18 Gene

MGI Knock Outs for SS18:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SS18 Gene

Localization for SS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SS18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SS18 Gene COMPARTMENTS Subcellular localization image for SS18 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10072425
GO:0005881 cytoplasmic microtubule IEA --
GO:0071564 npBAF complex IEA --
genes like me logo Genes that share ontologies with SS18: view

Pathways for SS18 Gene

genes like me logo Genes that share pathways with SS18: view

Pathways by source for SS18 Gene

1 KEGG pathway for SS18 Gene

Gene Ontology (GO) - Biological Process for SS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0000902 cell morphogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SS18: view

Compounds for SS18 Gene

(3) Novoseek inferred chemical compound relationships for SS18 Gene

Compound -log(P) Hits PubMed IDs
proline 23.7 3
glutamine 17.4 3
tyrosine 0 2
genes like me logo Genes that share compounds with SS18: view

Transcripts for SS18 Gene

Unigene Clusters for SS18 Gene

Synovial sarcoma translocation, chromosome 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SS18 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13:
SP14:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SS18 Gene

GeneLoc Exon Structure for
SS18
ECgene alternative splicing isoforms for
SS18

Expression for SS18 Gene

mRNA expression in normal human tissues for SS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SS18 Gene

SOURCE GeneReport for Unigene cluster for SS18 Gene Hs.129261

mRNA Expression by UniProt/SwissProt for SS18 Gene

Q15532-SSXT_HUMAN
Tissue specificity: Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas
genes like me logo Genes that share expressions with SS18: view

Orthologs for SS18 Gene

This gene was present in the common ancestor of animals.

Orthologs for SS18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SS18 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SS18 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SS18 36
  • 95.77 (n)
  • 98.56 (a)
SS18 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ss18 36
  • 91.95 (n)
  • 96.17 (a)
Ss18 16
Ss18 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SS18 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SS18 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ss18 36
  • 90.75 (n)
  • 94.98 (a)
chicken
(Gallus gallus)
Aves SS18 36
  • 89.23 (n)
  • 97.85 (a)
SS18 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SS18 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ss18-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ss18 36
  • 78.39 (n)
  • 84.11 (a)
Str.1351 36
zebrafish
(Danio rerio)
Actinopterygii ss18 36
  • 71.89 (n)
  • 74.18 (a)
ss18 37
  • 76 (a)
OneToOne
wufe02e04 36
fruit fly
(Drosophila melanogaster)
Insecta CG10555 37
  • 10 (a)
OneToMany
Species with no ortholog for SS18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SS18 Gene

ENSEMBL:
Gene Tree for SS18 (if available)
TreeFam:
Gene Tree for SS18 (if available)

Paralogs for SS18 Gene

Paralogs for SS18 Gene

genes like me logo Genes that share paralogs with SS18: view

Variants for SS18 Gene

Sequence variations from dbSNP and Humsavar for SS18 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs15101 -- 26,017,847(+) CCATG(C/T)TCCAG utr-variant-3-prime
rs475470 -- 26,088,944(-) CATCC(A/C)ATGGT intron-variant
rs488752 -- 26,081,638(-) AATAT(G/T)GTCAC intron-variant
rs489635 -- 26,041,737(+) ACCAC(A/C)ATAGC intron-variant
rs493484 -- 26,081,086(-) tttga(A/G)acgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SS18 Gene

Variant ID Type Subtype PubMed ID
esv2674101 CNV Deletion 23128226

Relevant External Links for SS18 Gene

HapMap Linkage Disequilibrium report
SS18

Disorders for SS18 Gene

UniProtKB/Swiss-Prot

SSXT_HUMAN
  • Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

(4) University of Copenhagen DISEASES for SS18 Gene

(5) Novoseek inferred disease relationships for SS18 Gene

Disease -log(P) Hits PubMed IDs
sarcoma synovial 96.2 51
sarcoma 66.1 5
ewings sarcoma 41.5 1
tumors 39.2 12
primary tumor 0.652 1

Relevant External Links for SS18

Genetic Association Database (GAD)
SS18
genes like me logo Genes that share disorders with SS18: view

Publications for SS18 Gene

  1. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. (PMID: 7951320) Clark J. … Cooper C.S. (Nat. Genet. 1994) 2 3 4 23
  2. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. (PMID: 7495284) Fligman I. … Ladanyi M. (Am. J. Pathol. 1995) 3 4 23
  3. Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. (PMID: 11368913) Brodin B. … Larsson O. (Gene 2001) 3 4 23
  4. The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. (PMID: 11423977) de Bruijn D.R. … Geurts van Kessel A. (Oncogene 2001) 3 4 23
  5. Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. (PMID: 16484776) de Bruijn D.R. … Geurts van Kessel A. (Cytogenet. Genome Res. 2006) 2 3 23

Products for SS18 Gene

Sources for SS18 Gene

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