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Aliases for SS18 Gene

Aliases for SS18 Gene

  • SS18, NBAF Chromatin Remodeling Complex Subunit 2
  • Synovial Sarcoma Translocation, Chromosome 18 2 3 5
  • Synovial Sarcoma Translocated To X Chromosome Protein 3 4
  • SSXT 3 4
  • SYT 3 4
  • Synovial Sarcoma, Translocated To X Chromosome 3
  • Protein SYT 4

External Ids for SS18 Gene

Previous HGNC Symbols for SS18 Gene

  • SSXT

Previous GeneCards Identifiers for SS18 Gene

  • GC18M023570
  • GC18M023308
  • GC18M021848
  • GC18M021850
  • GC18M020454
  • GC18M023596

Summaries for SS18 Gene

GeneCards Summary for SS18 Gene

SS18 (SS18, NBAF Chromatin Remodeling Complex Subunit) is a Protein Coding gene. Diseases associated with SS18 include sarcoma, synovial and biphasic synovial sarcoma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is SS18L2.

UniProtKB/Swiss-Prot for SS18 Gene

  • Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.

Gene Wiki entry for SS18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SS18 Gene

Genomics for SS18 Gene

Regulatory Elements for SS18 Gene

Promoters for SS18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SS18 on UCSC Golden Path with GeneCards custom track

Genomic Location for SS18 Gene

Chromosome:
18
Start:
26,016,253 bp from pter
End:
26,091,217 bp from pter
Size:
74,965 bases
Orientation:
Minus strand

Genomic View for SS18 Gene

Genes around SS18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SS18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SS18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SS18 Gene

Proteins for SS18 Gene

  • Protein details for SS18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15532-SSXT_HUMAN
    Recommended name:
    Protein SSXT
    Protein Accession:
    Q15532
    Secondary Accessions:
    • B0YJ95
    • Q16404
    • Q4VAX1
    • Q9BXC6

    Protein attributes for SS18 Gene

    Size:
    418 amino acids
    Molecular mass:
    45929 Da
    Quaternary structure:
    • Interacts with MLLT10. Isoform 1 interacts with RBM14 isoform 1. Isoform 2 interacts with RBM14 isoform 1.
    SequenceCaution:
    • Sequence=AAK21314.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA55792.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SS18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SS18 Gene

Proteomics data for SS18 Gene at MOPED

Post-translational modifications for SS18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SS18 Gene

Domains & Families for SS18 Gene

Protein Domains for SS18 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15532

UniProtKB/Swiss-Prot:

SSXT_HUMAN :
  • Belongs to the SS18 family.
Family:
  • Belongs to the SS18 family.
genes like me logo Genes that share domains with SS18: view

No data available for Gene Families for SS18 Gene

Function for SS18 Gene

Molecular function for SS18 Gene

UniProtKB/Swiss-Prot Function:
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
genes like me logo Genes that share phenotypes with SS18: view

Human Phenotype Ontology for SS18 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SS18 Gene

MGI Knock Outs for SS18:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for SS18 Gene

Localization for SS18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SS18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SS18 Gene COMPARTMENTS Subcellular localization image for SS18 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SS18 Gene

Pathways & Interactions for SS18 Gene

genes like me logo Genes that share pathways with SS18: view

Pathways by source for SS18 Gene

1 KEGG pathway for SS18 Gene

Gene Ontology (GO) - Biological Process for SS18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 15919756
GO:0048013 ephrin receptor signaling pathway IEA --
GO:0097150 neuronal stem cell population maintenance IEA --
genes like me logo Genes that share ontologies with SS18: view

No data available for SIGNOR curated interactions for SS18 Gene

Drugs & Compounds for SS18 Gene

(3) Drugs for SS18 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SS18: view

Transcripts for SS18 Gene

Unigene Clusters for SS18 Gene

Synovial sarcoma translocation, chromosome 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SS18 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - -
SP12: - - - - -
SP13:
SP14:

ExUns: 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for SS18 Gene

GeneLoc Exon Structure for
SS18
ECgene alternative splicing isoforms for
SS18

Expression for SS18 Gene

mRNA expression in normal human tissues for SS18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SS18 Gene

This gene is overexpressed in Fetal gut (10.9), Testis (10.3), and Placenta (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SS18 Gene



SOURCE GeneReport for Unigene cluster for SS18 Gene Hs.129261

mRNA Expression by UniProt/SwissProt for SS18 Gene

Q15532-SSXT_HUMAN
Tissue specificity: Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
genes like me logo Genes that share expression patterns with SS18: view

Protein tissue co-expression partners for SS18 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SS18 Gene

Orthologs for SS18 Gene

This gene was present in the common ancestor of animals.

Orthologs for SS18 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SS18 35
  • 95.77 (n)
  • 98.56 (a)
SS18 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ss18 35
  • 91.95 (n)
  • 96.17 (a)
Ss18 16
Ss18 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ss18 35
  • 90.75 (n)
  • 94.98 (a)
oppossum
(Monodelphis domestica)
Mammalia SS18 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SS18 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SS18 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SS18 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves SS18 35
  • 89.23 (n)
  • 97.85 (a)
SS18 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SS18 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ss18 35
  • 78.39 (n)
  • 84.11 (a)
Str.1351 35
African clawed frog
(Xenopus laevis)
Amphibia ss18-prov 35
zebrafish
(Danio rerio)
Actinopterygii ss18 35
  • 71.89 (n)
  • 74.18 (a)
wufe02e04 35
ss18 36
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10555 36
  • 10 (a)
OneToMany
Species with no ortholog for SS18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SS18 Gene

ENSEMBL:
Gene Tree for SS18 (if available)
TreeFam:
Gene Tree for SS18 (if available)

Paralogs for SS18 Gene

Paralogs for SS18 Gene

genes like me logo Genes that share paralogs with SS18: view

Variants for SS18 Gene

Sequence variations from dbSNP and Humsavar for SS18 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs15101 -- 26,017,847(+) CCATG(C/T)TCCAG utr-variant-3-prime
rs489635 -- 26,041,737(+) ACCAC(A/C)ATAGC intron-variant
rs572990 -- 26,075,996(-) cttat(G/T)gctag intron-variant
rs573162 -- 26,075,925(-) tattt(C/T)ctagc intron-variant
rs600619 -- 26,082,413(-) AACTT(C/T)TATTC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SS18 Gene

Variant ID Type Subtype PubMed ID
esv2674101 CNV Deletion 23128226

Variation tolerance for SS18 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SS18 Gene

HapMap Linkage Disequilibrium report
SS18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SS18 Gene

Disorders for SS18 Gene

MalaCards: The human disease database

(16) MalaCards diseases for SS18 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma, synovial
  • synovial sarcoma
biphasic synovial sarcoma
  • biphasic sarcoma of synovium
spindle cell synovial sarcoma
  • synovial sarcoma with spindle cell components
sarcoma
  • connective and soft tissue neoplasm
monophasic synovial sarcoma
  • monophasic sarcoma of synovium
- elite association - COSMIC cancer census association via MalaCards
Search SS18 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SSXT_HUMAN
  • Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). {ECO:0000269 PubMed:7495284, ECO:0000269 PubMed:7539744}.

Relevant External Links for SS18

Genetic Association Database (GAD)
SS18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SS18
genes like me logo Genes that share disorders with SS18: view

No data available for Genatlas for SS18 Gene

Publications for SS18 Gene

  1. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. (PMID: 7951320) Clark J. … Cooper C.S. (Nat. Genet. 1994) 2 3 4 23 67
  2. Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. (PMID: 16484776) de Bruijn D.R. … Geurts van Kessel A. (Cytogenet. Genome Res. 2006) 2 3 23
  3. Cytosolic SYT/SS18 isoforms are actin-associated proteins that function in matrix-specific adhesion. (PMID: 19649286) Kim J. … Parks W.C. (PLoS ONE 2009) 3 23
  4. Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1. (PMID: 19936258) Cironi L. … Stamenkovic I. (PLoS ONE 2009) 3 23
  5. Cryptic chromosome rearrangement resulting in SYT-SSX2 fusion gene in a monophasic synovial sarcoma. (PMID: 18992642) Torres L. … Teixeira M.R. (Cancer Genet. Cytogenet. 2008) 3 23

Products for SS18 Gene

Sources for SS18 Gene

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