Aliases for SRY Gene
External Ids for SRY Gene
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for SRY Gene
SRY (Sex Determining Region Y) is a Protein Coding gene. Diseases associated with SRY include 46xy sex reversal 1 and 46xx sex reversal 1. Among its related pathways are Androgen Signaling and Regulation of Androgen receptor activity. GO annotations related to this gene include transcription factor binding and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. An important paralog of this gene is SOX3.
UniProtKB/Swiss-Prot for SRY Gene
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). Involved in different aspects of gene regulation including promoter activation or repression (By similarity). Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5-[AT]AACAA[AT]-3.