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SRY Gene

protein-coding   GIFtS: 59

GC0YM002698
sex determining region Y
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for SRY

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
OTTHUMP00000034324 2
TDF 1, 2, 3, 5
TDY 2, 5
Descriptions
Testis-determining factor 2, 3
essential protein for sex determination in human males 2
sex determining region Y 2
sex determining region protein 2
sex-determining region on Y 2
External Ids
HGNC: 113111
Entrez Gene: 67362
UniProtKB: Q050663
Ensembl: ENSG000001848957
Search outside databases for aliases for SRY gene

Previous GC identifers: GC0YM002562 GC0YM002300

Summaries
for SRY

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for SRY:
This intronless gene encodes a transcription factor that is a member of the high mobility group
(HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF),
which initiates male sex determination. Mutations in this gene give rise to XY females with
gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this
gene to the X chromosome causes XX male syndrome. [provided by RefSeq]

UniProtKB/Swiss-Prot: SRY_HUMAN, Q05066
Function: Transcriptional regulator which control a genetic switch in male development. It is
necessary and sufficient for initiating male sex determination by directing the development of
supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By
similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic
neurons (By similarity). Involved in different aspects of gene regulation including promoter
activation or repression (By similarity). Facilitates DNA bending. SRY HMG box recognizes DNA by
partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA
consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity)

Gene Wiki entry for SRY

Genomic Location
for SRY

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the SRY gene  

Entrez Gene cytogenetic band: Yp11.3   Ensembl cytogenetic band:  Yp11.31   HGNC cytogenetic band: Yp11.3

SRY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YM002698:     (about GC identifiers)

Start:
 2,714,896 bp from pter
End:
 2,715,792 bp from pter
Size:
 897 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000024.8  NT_011896.9  

Proteins
for SRY

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: SRY_HUMAN, Q05066 (See protein sequence)
Recommended Name: Sex-determining region Y protein  
Size: 204 amino acids; 23884 Da
Subunit: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1.
The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is
sensitive to dissociation by Ran in the GTP-bound form (By similarity). Interaction with PARP1
impaired its DNA-binding activity (By similarity)
Subcellular location: Nucleus speckle. Cytoplasm. Note=Colocalizes with SOX6 in speckles.
Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and
tyrosine hydroxylase (TH) (By similarity)
Miscellaneous: DNA binding and bending properties of the HMG domains of human and mouse SRY differ
form each other. Human SRY shows more extensive minor groove contacts with DNA and a lower
specificity of sequence recognition than mouse SRY
PDB structures from and Proteopedia :
1HRY (3D)    1HRZ (3D)    1J46 (3D)    1J47 (3D)    

Post-translational modifications:

  • Phosphorylated on serine residues by PKA. Phosphorylation by PKA enhances its DNA-binding activity
    and stimulates transcription repression. Acetylation of Lys-136 contributes to its nuclear
    localization and enhances its interaction with KPNB1. Deacetylated by HDAC3. Poly-ADP-ribosylated
    by PARP1. ADP-ribosylation reduces its DNA-binding activity1


    • REFSEQ proteins: NP_003131.1  

    ENSEMBL proteins: 
    ENSP00000372547 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SRY)
    Human Recombinant Proteins from Abnova (SRY)
                  OriGene Purified Recombinant Human Protein: SRY 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS1425584 8265659
    GO:0005737 cytoplasm IEA--
    GO:0016607 nuclear speck IEA--
    About this table

    Antibodies for SRY: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SRY
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SRY), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (SRY)
    Novus Biologicals Antibody for SRY

    Assays for SRY: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for SRY

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR000910 HMG_HMG1/HMG2
     IPR017253 Sex-determining_region_Y


       GeneDecks  SRY for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q05066

    ProtoNet protein and cluster: Q05066

    UniProtKB/Swiss-Prot: SRY_HUMAN, Q05066
    Similarity: Belongs to the SRY family
    Similarity: Contains 1 HMG box DNA-binding domain

    Gene Function
    for SRY

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SRY)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003140

                  Applied Biosystems Silencer® siRNAs for SRY

                  Sigma-Aldrich siRNA for SRY  
                         Sigma-Aldrich shRNA for SRY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003140
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003140
                                     untagged cDNA clone in CMV expression vector: NM_003140 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003140

    UniProtKB/Swiss-Prot: SRY_HUMAN, Q05066
    Function: Transcriptional regulator which control a genetic switch in male development. It is
    necessary and sufficient for initiating male sex determination by directing the development of
    supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By
    similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic
    neurons (By similarity). Involved in different aspects of gene regulation including promoter
    activation or repression (By similarity). Facilitates DNA bending. SRY HMG box recognizes DNA by
    partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA
    consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity)

    Genatlas biochemistry entry for SRY:
    sex determining region Y,testis determining factor antagonized by DAX1,modulator of LINE
    retroposons promoter activity

    3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sry):

    endocrine/exocrine glandlethality-prenatal/perinatalreproductive system

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity IEA--
    GO:0005515 protein binding IPI15527767
    GO:0016563 transcription activator activity NAS--
    About this table

    Pathways & Interactions
    for SRY

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  SRY  (Your Favorite Gene powered by Ingenuity) 
     Androgen Signaling

       GeneDecks  SRY for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  SRY 


    5/17 Interacting proteins for SRY (ENSP000003725473 Q050661, 2) via UniProtKB, MINT, and/or STRING (see all 17 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R2Q155992STRING (score=.901) MINT-68607 MINT-68601 MINT-60076
    SMAD3P840221EBI-464987, EBI-347161
    ZFYENSP000001550933STRING (score=.962)
    ZFXENSP000003049853STRING (score=.95)
    NR1I2ENSP000003365283STRING (score=.944)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0030154 cell differentiation IEA--
    GO:0030238 male sex determination NAS1695712
    About this table

    Drugs & Compounds
    for SRY

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for SRY
    10/12 Novoseek chemical compound relationships for SRY gene (see all 12 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dmrt 62.77 1 16868052 (1)
    deoxyribonucleic acid 22.96 8 9093193 (4), 10992198 (1)
    thymine 8.68 2 15211655 (1)
    steroid 7.27 3 9343329 (1), 18654764 (1), 11585838 (1)
    tyrosine 2.23 1 8019555 (1)
    estradiol 0.00 1 11268892 (1)
    lysine 0.00 3 9678356 (1), 15297880 (1)
    oligonucleotide 0.00 2 18156714 (1), 10584191 (1)
    zinc 0.00 3 7913293 (1), 18156714 (1), 18445271 (1)
    silver 0.00 1 15791342 (1)
    About this table


    Transcripts
    for SRY

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (SRY)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003140

                  Sigma-Aldrich siRNA for SRY  
                         Sigma-Aldrich shRNA for SRY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003140  

    REFSEQ mRNAs for SRY gene: 

    NM_003140.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003140  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003140
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003140
                                     untagged cDNA clone in CMV expression vector: NM_003140 

    Additional cDNA sequence: 

    BC074923.2 BC074924.2 L10101.1 S53156.1 S56543.1 Z48512.1 Z48513.1 

    2 DOTS entries:

    DT.408945  DT.120652321 

    6 AceView cDNA sequences:

    BC074924 NM_003140 BC074923 L10101 Z48513 Z48512 

    highest scoring ESTs for SRY:

    L10101 S53156 S56543 BC074923 BC074924 NM_003140 L10102 Z48512 Z48513 BE349458 

    Unigene Cluster for SRY:

    Sex determining region Y
    Hs.1992
    Unigene Representative Sequence: NM_003140


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000383070  

    Expression
    for SRY

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    SRY expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for SRY

    1 / 2 / 3

    3 probe-sets matching SRY gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		32864_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 L10102 0.20 1.00 0.72 1

    		207893_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003140 0.60 1.00 0.82 1

    		207893_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CACAGAGAGA

    SOURCE GeneReport for Unigene cluster: Hs.1992

    Expression variation in blood from EXPOLDB for SRY

    Orthologs
    for SRY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SRY gene from 2 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    chimpanzee
    (Pan troglodytes)    		 SRY1   -- sex determining region Y 98.69(n)
    96.57(a)    		 449510  NM_001008988.1  NP_001008988.1 
    mouse
    (Mus musculus)    		 Sry5 Y sex determining region of Chr Y   -- X67204 
    About this table        Species with no ortholog for SRY

    ENSEMBL Gene Tree for SRY

    Paralogs
    for SRY

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for SRY gene
    SOX92  SOX102  SOX82  

    SNPs/Variants
    for SRY

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for SRY

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 480000   disorders: 306100  235600  

    UniProtKB/Swiss-Prot: SRY_HUMAN, Q05066

  • Defects in SRY are a cause of gonadal dysgenesis XY female type (GDXY) [MIM:306100]; also
    known as 'XY females' or Swyer syndrome. Patients are found to have a 46,XY karyotype. They suffer
    rapid and early degeneration of their gonads, which are present in the adult as 'streak gonads',
    consisting mainly of fibrous tissue and variable amounts of ovarian stroma. As a result these
    patients do not develop secondary sexual characteristics at puberty. The external genitalia in
    these subjects are completely female, and Muellerian structures are normal. In contrast, subjects
    with 46,XY partial gonadal dysgenesis have ambiguous genitalia, a mix of Muellerian and Wolffian
    structures, and dysgenic gonads
  • Defects in SRY are found in Turner syndrome, a disease characterized by gonadal dysgenesis
    with short stature, "streak gonads", variable abnormalities such as webbing of the neck, cubitus
    valgus, cardiac defects, low posterior hair line. The phenotype is female. Turner syndrome has its
    basis in a 45,X chromosomal aberration
  • Defects in SRY are a cause of true hermaphroditism [MIM:235600]. A true hermaphrodite must
    have both mature ovarian and mature testicular tissue with histologic evidence of follicles and
    tubules, respectively. It is a genetically heterogeneous condition. The genotype of most affected
    individuals is 46,XX, but many have 46,XY or a mosaic of 46,XX/46,XY. True hermaphroditism can be
    caused also by chromosomal translocation

    • 10/33 Novoseek disease relationships for SRY gene (see all 33 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    pure gonadal dysgenesis 92.59 25 17063144 (3), 8840551 (2), 8353496 (2), 16106197 (2) (see all 18)
    swyer syndrome 91.47 15 15183752 (2), 9341876 (2), 16846094 (2), 10803875 (1) (see all 11)
    hermaphroditism, true 89.81 14 12215841 (2), 1740318 (1), 1297452 (1), 7702097 (1) (see all 11)
    gonadoblastoma 87.01 6 10614539 (1), 9137884 (1), 7814028 (1), 8085778 (1) (see all 6)
    primary amenorrhea 77.66 1 17493621 (1)
    campomelic dysplasia 77.27 2 10798354 (1), 11990798 (1)
    gonadal dysgenesis mixed 76.70 6 16045561 (2), 15223166 (2), 11694229 (1), 9250915 (1)
    turners syndrome 73.81 10 15223166 (2), 8530595 (2), 15687343 (1), 19030103 (1) (see all 8)
    virilization 73.73 4 7913293 (1), 15652914 (1), 8033363 (1), 12818524 (1)
    testicular regression syndrome 73.09 1 16106197 (1)
    About this table

    Genatlas disease: SRY
    gonadal dysgenesis,Swyer syndrome,XY female complete or incomplete sex reversal

    GeneTests: SRY
    46

    Human Gene Mutation Database: SRY
    Genetic Association Database: SRY
    Human Genome Epidemiology Navigator: SRY (1 document)

    Medical News
    for SRY

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for SRY

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/319 PubMed articles for SRY gene (see all 319 ):

    Search for SRY

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SRY

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6736 HGNC: 11311 AceView: SRY Ensembl:ENSG00000184895 euGenes: HUgn6736
    ECgene: SRY H-InvDB: SRY

    Other Databases showing SRY

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing SRY

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for SRY Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.genetests.org/query?gene=SRY
    Protein Spotlighthttp://www.expasy.org/spotlight/back_issues/sptlt080.shtml
    Wikipedia http://en.wikipedia.org/wiki/SRY

    Licensable Technologies
    for SRY

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for SRY

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for SRY:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for SRY-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for SRY Antibodies for SRY
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SRY Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (SRY)
     Antibodies (SRY)
     Chimera RNAi (SRY)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (SRY)
     Antibodies (SRY)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for SRY




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for SRY

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