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Aliases for SRXN1 Gene

Aliases for SRXN1 Gene

  • Sulfiredoxin 1 2 3
  • C20orf139 3 4
  • SRX 3 4
  • Sulfiredoxin 1 Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 139 2
  • Sulfiredoxin-1 3
  • EC 1.8.98.2 4
  • Npn3 3
  • SRX1 3

External Ids for SRXN1 Gene

Previous Symbols for SRXN1 Gene

  • C20orf139

Summaries for SRXN1 Gene

GeneCards Summary for SRXN1 Gene

SRXN1 (Sulfiredoxin 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on a sulfur group of donors and sulfiredoxin activity.

UniProtKB/Swiss-Prot for SRXN1 Gene

  • Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

Gene Wiki entry for SRXN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRXN1 Gene

Genomics for SRXN1 Gene

Genomic Location for SRXN1 Gene

Start:
646,615 bp from pter
End:
653,370 bp from pter
Size:
6,756 bases
Orientation:
Minus strand

Genomic View for SRXN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRXN1 Gene

Regulatory Elements for SRXN1 Gene

Proteins for SRXN1 Gene

  • Protein details for SRXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYN0-SRXN1_HUMAN
    Recommended name:
    Sulfiredoxin-1
    Protein Accession:
    Q9BYN0
    Secondary Accessions:
    • B2R543
    • Q8NDM3
    • Q96AK6

    Protein attributes for SRXN1 Gene

    Size:
    137 amino acids
    Molecular mass:
    14259 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SRXN1 Gene

neXtProt entry for SRXN1 Gene

Proteomics data for SRXN1 Gene at MOPED

Post-translational modifications for SRXN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRXN1 Gene

Domains for SRXN1 Gene

Protein Domains for SRXN1 Gene

UniProtKB/Swiss-Prot:

SRXN1_HUMAN
Family:
  • Belongs to the sulfiredoxin family.:
    • Q9BYN0
genes like me logo Genes that share domains with SRXN1: view

No data available for Gene Families for SRXN1 Gene

Function for SRXN1 Gene

Molecular function for SRXN1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
UniProtKB/Swiss-Prot Function: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

Enzyme Numbers (IUBMB) for SRXN1 Gene

Gene Ontology (GO) - Molecular Function for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors IDA 15448164
GO:0032542 sulfiredoxin activity IEA --
genes like me logo Genes that share ontologies with SRXN1: view

Phenotypes for SRXN1 Gene

genes like me logo Genes that share phenotypes with SRXN1: view

Animal Models for SRXN1 Gene

MGI Knock Outs for SRXN1:

miRNA for SRXN1 Gene

miRTarBase miRNAs that target SRXN1

No data available for Transcription Factor Targeting and HOMER Transcription for SRXN1 Gene

Localization for SRXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRXN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRXN1 Gene COMPARTMENTS Subcellular localization image for SRXN1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 15448164
genes like me logo Genes that share ontologies with SRXN1: view

Pathways for SRXN1 Gene

SuperPathways for SRXN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IDA 15448164
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with SRXN1: view

No data available for Pathways by source for SRXN1 Gene

Compounds for SRXN1 Gene

(1) HMDB Compounds for SRXN1 Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with SRXN1: view

Transcripts for SRXN1 Gene

mRNA/cDNA for SRXN1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(234) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRXN1 Gene

Sulfiredoxin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRXN1 Gene

No ASD Table

Relevant External Links for SRXN1 Gene

GeneLoc Exon Structure for
SRXN1
ECgene alternative splicing isoforms for
SRXN1

Expression for SRXN1 Gene

mRNA expression in normal human tissues for SRXN1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRXN1 Gene

SOURCE GeneReport for Unigene cluster for SRXN1 Gene Hs.516830

mRNA Expression by UniProt/SwissProt for SRXN1 Gene

Q9BYN0-SRXN1_HUMAN
Tissue specificity: Widely expressed with highest levels in kidney, lung, spleen and thymus.
genes like me logo Genes that share expressions with SRXN1: view

Orthologs for SRXN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRXN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRXN1 36
  • 99.51 (n)
  • 98.54 (a)
SRXN1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRXN1 36
  • 90.51 (n)
  • 94.89 (a)
SRXN1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRXN1 36
  • 86.92 (n)
  • 90.65 (a)
SRXN1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srxn1 36
  • 86.27 (n)
  • 90.44 (a)
Srxn1 16
Srxn1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRXN1 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRXN1 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srxn1 36
  • 84.8 (n)
  • 88.24 (a)
chicken
(Gallus gallus)
Aves SRXN1 36
  • 69.88 (n)
  • 72.29 (a)
zebrafish
(Danio rerio)
Actinopterygii srxn1 36
  • 59 (n)
  • 61.95 (a)
srxn1 37
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6762 36
  • 62.73 (n)
  • 58.18 (a)
CG6762 37
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRX1 37
  • 32 (a)
OneToOne
SRX1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
OneToOne
Species with no ortholog for SRXN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRXN1 Gene

ENSEMBL:
Gene Tree for SRXN1 (if available)
TreeFam:
Gene Tree for SRXN1 (if available)

Paralogs for SRXN1 Gene

No data available for Paralogs for SRXN1 Gene

Variants for SRXN1 Gene

Sequence variations from dbSNP and Humsavar for SRXN1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8297 -- 646,770(+) CCAAG(A/G)GACTG utr-variant-3-prime
rs911443 -- 650,525(+) GAGAC(C/T)CCATT intron-variant
rs2008022 -- 650,781(+) TGATG(A/C)CTACC intron-variant
rs3746799 -- 648,569(+) GTAGC(C/T)GGTGA utr-variant-3-prime
rs4393812 -- 650,446(+) CACAG(C/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRXN1 Gene

Variant ID Type Subtype PubMed ID
nsv912573 CNV Loss 21882294
dgv4512n71 CNV Loss 21882294
nsv522812 CNV Loss 19592680

Relevant External Links for SRXN1 Gene

HapMap Linkage Disequilibrium report
SRXN1

Disorders for SRXN1 Gene

Relevant External Links for SRXN1

Genetic Association Database (GAD)
SRXN1
genes like me logo Genes that share disorders with SRXN1: view

No data available for UniProtKB/Swiss-Prot for SRXN1 Gene

Publications for SRXN1 Gene

  1. Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. (PMID: 15952770) Jonsson T.J. … Lowther W.T. (Biochemistry 2005) 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. (PMID: 18172504) JAPnsson T.J. … Lowther W.T. (Nature 2008) 3 23
  4. Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. (PMID: 19561357) Park J.W. … Chock P.B. (J. Biol. Chem. 2009) 3 23
  5. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. (PMID: 15448164) Chang T.-S. … Rhee S.G. (J. Biol. Chem. 2004) 3 4

Products for SRXN1 Gene

  • Addgene plasmids for SRXN1

Sources for SRXN1 Gene

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