SRXN1 Gene
protein-coding GIFtS: 48
GCID: GC20M000577
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sulfiredoxin 1(Previous names: chromosome 20 open reading frame 139, sulfiredoxin 1 homolog...)
(Previous symbol: C20orf139)
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Aliases
for SRXN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sulfiredoxin 11 2 | | Chromosome 20 Open Reading Frame 1391 | | C20orf1391 2 3 | | DJ850E9.21 | | Npn31 2 | | Sulfiredoxin 1 Homolog (S. Cerevisiae)1 | | SRX11 2 | | Sulfiredoxin-11 | | SRX2 3 | | EC 1.8.98.23 | | YKL086W1 | | |
Export aliases for SRXN1 gene to outside databases |
Summaries
for SRXN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0Function: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure tooxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze thereduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase
Gene Wiki entry for SRXN1
|
Genomic Views
for SRXN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRXN1 gene promoter:
RFX1 Sox5 Pbx1a p53 AP-4 HEN1 Pax-4a RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRXN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRXN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13SRXN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M000577: view genomic region
(about GC identifiers)
Start:
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627,259 bp from pter |
End:
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656,444 bp from pter |
Size:
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29,186 bases |
Orientation:
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minus strand |
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Proteins
for SRXN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0 (See
protein sequence)Recommended Name: Sulfiredoxin-1 Size: 137 amino acids; 14259 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Cytoplasm
6/7 PDB 3D structures from  and Proteopedia  for SRXN1 (see all 7):1XW3 (3D)
1XW4 (3D)
1YZS (3D)
2B6F (3D)
2RII (3D)
3CYI (3D)
Secondary accessions: B2R543 Q8NDM3 Q96AK6Explore the universe of human proteins at neXtProt for SRXN1: NX_Q9BYN0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYN0
SRXN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542763.1
ENSEMBL proteins: ENSP00000371388
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SRXN1 for ontologies About GeneDecksing
SRXN1 Antibody Products:
Assay Products for SRXN1: |
Protein
Domains /
Families
for SRXN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRXN1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BYN0ProtoNet protein and cluster: Q9BYN0 UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0Similarity: Belongs to the sulfiredoxin family |
Function
for SRXN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0Function: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure tooxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze thereduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferaseCatalytic activity: Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP +phosphate + R-S-S-REnzyme Number (IUBMB): EC 1.8.98.21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRXN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRXN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRXN1 (NM_080725) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRXN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRXN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRXN1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SRXN1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SRXN1:
|
Pathways & Interactions
for SRXN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRXN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for SRXN1 (Q9BYN03 ENSP000003713884) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006979 | response to oxidative stress |
IDA | 15448164 |
SRXN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SRXN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRXN1
1 HMDB Compound for SRXN1 About this table
Search CenterWatch for drugs/clinical trials and news about SRXN1
|
Transcripts
for SRXN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRXN1 gene: NM_080725.2 Unigene Cluster for SRXN1: Sulfiredoxin 1 Hs.516830 [show with all ESTs]Unigene Representative Sequence: NM_0807252 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381962(uc002wea.3) ENST00000488788(uc002web.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRXN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRXN1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRXN1 (NM_080725) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRXN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRXN1 |
Additional cDNA sequence: AF075053.1 AK098418.1 AK127435.1 AK312054.1 AL833944.1 AY427953.1 BC017001.1 BC032604.1 BC047707.1 4 DOTS entries: DT.447705 DT.100768915 DT.101984631 DT.120825196 24/234 AceView cDNA sequences (see all 234): AI471423 BQ233189 AI087110 AI762643 BF436510 NM_080725 BX401145 CA444797 AI986463 F02022 BG496225 AI949423 CD742692 AW301167 BQ227600 BQ214478 AW294168 AV717641 AL833944 AI302670 BU190639 BF941711 AW079427 H18986
GeneLoc Exon Structure
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Expression
for SRXN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRXN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGATGTAAG
About this image
See SRXN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRXN1
SOURCE GeneReport for Unigene cluster: Hs.516830
UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0Tissue specificity: Widely expressed with highest levels in kidney, lung, spleen and thymus
SABiosciences Expression via Pathway-Focused PCR Arrays including SRXN1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRXN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRXN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRXN1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRXN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRXN1 |
Orthologs
for SRXN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SRXN1 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for SRXN1 (if available)
TreeFam Gene Tree for SRXN1 (if available) |
Paralogs
for SRXN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRXN1 gene
SRXN1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for SRXN1
PGOHUM00000243878 PGOHUM00000250535 PGOHUM00000235662
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Genomic Variants
for SRXN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRXN1 (627259 - 656444 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SRXN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRXN1 |
|
Disorders
/ Diseases
for SRXN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRXN1 for disorders About GeneDecksing
10  diseases for SRXN1: About MalaCardsnonspecific interstitial pneumonia idiopathic pulmonary fibrosis pulmonary fibrosis acute myeloid leukemia
myeloid leukemia fibrosis pneumonia hepatocellular carcinoma
leukemia carcinoma
Export disorders for SRXN1 gene to outside databases
|
Publications
for SRXN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRXN1 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with SRXN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. (PubMed id 15952770)1, 2, 9 Jonsson T.J.... Lowther W.T. (2005)
- Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2- cys peroxiredoxins. (PubMed id 15590625)1, 2 Woo H.A....Rhee S.G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. (PubMed id 15448164)1, 2 Chang T.-S.... Rhee S.G. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Deglutathionylation of 2-Cys peroxiredoxin is specifi cally catalyzed by sulfiredoxin. (PubMed id 19561357)1, 9 Park J.W....Chock P.B. (2009)
- Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. (PubMed id 18172504)1, 9 Jonsson T.J....Lowther W.T. (2008)
- Genetic polymorphisms and protein expression of NRF2 a nd Sulfiredoxin predict survival outcomes in breast cancer. (PubMed id 22964583)1 Hartikainen J.M....Soini Y. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Nuclear factor erythroid-derived 2-like 2 (Nrf2) and D J1 are prognostic factors in lung cancer. (PubMed id 21943684)1 Merikallio H....Soini Y. (2012)
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External Searches for SRXN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SRXN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRXN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRXN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRXN1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SRXN1 gene:
Search GeneIP for patents involving SRXN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRXN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for SRXN1 | | OriGene shRNA RFP for SRXN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRXN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRXN1 | | | OriGene Protein Over-expression Lysate for SRXN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRXN1 | | OriGene 3'-UTR Clone for SRXN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRXN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRXN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRXN1 | | OriGene Custom Protein Services for SRXN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRXN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRXN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRXN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRXN1 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRXN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRXN1 |
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 |  |  |  | |
| | | | Search Tocris compounds for SRXN1 |
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 | | | SRXN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRXN1 |
|  |  |  | | | | ThermoFisher Antibodies for SRXN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRXN1 |
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