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SRXN1 Gene

protein-coding   GIFtS: 49
GCID: GC20M000630

Sulfiredoxin 1

(Previous names: chromosome 20 open reading frame 139, sulfiredoxin 1 homolog...)
(Previous symbol: C20orf139)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sulfiredoxin 11 2     Npn32
C20orf1391 2 3     SRX12
SRX2 3     sulfiredoxin-12
Chromosome 20 Open Reading Frame 1391     EC 1.8.98.23
Sulfiredoxin 1 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 161321   Entrez Gene: 1408092   Ensembl: ENSG000002713037   UniProtKB: Q9BYN03   

Export aliases for SRXN1 gene to outside databases

Previous GC identifer: GC20M000577


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRXN1 Gene:
SRXN1 (sulfiredoxin 1) is a protein-coding gene. Diseases associated with SRXN1 include nonspecific interstitial pneumonia, and idiopathic pulmonary fibrosis. GO annotations related to this gene include oxidoreductase activity, acting on a sulfur group of donors and sulfiredoxin activity.

UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0
Function: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to
oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the
reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase

Gene Wiki entry for SRXN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRXN1 gene promoter:
         RFX1   Sox5   Pbx1a   p53   AP-4   HEN1   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRXN1 promoter sequence
   Search Chromatin IP Primers for SRXN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRXN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

SRXN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRXN1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M000630:  view genomic region     (about GC identifiers)

Start:
627,259 bp from pter      End:
634,014 bp from pter
Size:
6,756 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0 (See protein sequence)
Recommended Name: Sulfiredoxin-1  
Size: 137 amino acids; 14259 Da
Cofactor: Magnesium (By similarity)
Selected PDB 3D structures from and Proteopedia for SRXN1 (see all 7):
1XW3 (3D)        1XW4 (3D)        1YZS (3D)        2B6F (3D)        2RII (3D)        3CYI (3D)    
Secondary accessions: B2R543 Q8NDM3 Q96AK6

Explore the universe of human proteins at neXtProt for SRXN1: NX_Q9BYN0

Explore proteomics data for SRXN1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SRXN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542763.1  
    ENSEMBL proteins: 
     ENSP00000371388  

    SRXN1 Human Recombinant Protein Products:

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    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for SRXN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003115 ParB/Sulfiredoxin_dom
     IPR016692 Sulfiredoxin

    Graphical View of Domain Structure for InterPro Entry Q9BYN0

    ProtoNet protein and cluster: Q9BYN0

    UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0
    Similarity: Belongs to the sulfiredoxin family


    SRXN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRXN1_HUMAN, Q9BYN0
    Function: Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to
    oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the
    reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase
    Catalytic activity: Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) +
    ADP + phosphate + R-S-S-R

         Enzyme Number (IUBMB): EC 1.8.98.21

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016667oxidoreductase activity, acting on a sulfur group of donors IDA15448164
    GO:0032542sulfiredoxin activity IEA--
         
    SRXN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRXN1:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srxn1):
     homeostasis/metabolism  immune system  mortality/aging 

    SRXN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srxn1tm1Mtol for SRXN1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRXN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRXN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRXN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRXN1

    miRNA
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    miRTarBase miRNAs that target SRXN1:
    hsa-mir-1 (MIRT003772), hsa-mir-96-5p (MIRT027877)

    Block miRNA regulation of human, mouse, rat SRXN1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate SRXN1:
    hsa-miR-485-5p hsa-miR-3673 hsa-miR-206 hsa-miR-328 hsa-miR-613 hsa-miR-1 hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidSRXN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRXN1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: SRXN1 (NM_080725)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRXN1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRXN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRXN1_HUMAN, Q9BYN0: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA15448164

    SRXN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRXN1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SRXN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SRXN1 (Q9BYN03 ENSP000003713884) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K53, ENSP000003564254I2D: score=1 STRING: ENSP00000356425
    PRDX2P321193I2D: score=5 
    PRDX1ENSP000002627464STRING: ENSP00000262746
    SLMAPENSP000002959514STRING: ENSP00000295951
    PRDX5ENSP000002654624STRING: ENSP00000265462
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress IDA15448164
    GO:0055114oxidation-reduction process ----

    SRXN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRXN1

    1 HMDB Compound for SRXN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRXN1 gene: 
    NM_080725.2  

    Unigene Cluster for SRXN1:

    Sulfiredoxin 1
    Hs.516830  [show with all ESTs]
    Unigene Representative Sequence: NM_080725
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000381962(uc002wea.3)
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate SRXN1:
    hsa-miR-485-5p hsa-miR-3673 hsa-miR-206 hsa-miR-328 hsa-miR-613 hsa-miR-1 hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidSRXN1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SRXN1
    Predesigned siRNA for gene silencing in human, mouse, rat SRXN1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRXN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRXN1
    Primer
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    OriGene qPCR primer pairs and template standards for SRXN1
    OriGene qSTAR qPCR primer pairs in human, mouse for SRXN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRXN1
      QuantiTect SYBR Green Assays in human, mouse, rat SRXN1
      Search QuantiFast Probe-based Assays in human, mouse, rat SRXN1

    Additional mRNA sequence: 

    AF075053.1 AK098418.1 AK127435.1 AK312054.1 AL833944.1 AY427953.1 BC017001.1 BC032604.1 
    BC047707.1 

    4 DOTS entries:

    DT.447705  DT.100768915  DT.120825196  DT.101984631 

    Selected AceView cDNA sequences (see all 234):

    BQ226886 AW194845 BU175342 W57811 AW301167 BM907165 AW173108 BM772435 
    AA707264 CF131864 BU620444 BX401145 BQ233189 BU186388 AI480157 AI302670 
    BF448139 BC017001 BF447275 AI471423 AI762643 H18986 AI344486 AI949423 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRXN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGATGTAAG
    SRXN1 Expression
    About this image

    SRXN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRXN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516830

    UniProtKB/Swiss-Prot: SRXN1_HUMAN, Q9BYN0
    Tissue specificity: Widely expressed with highest levels in kidney, lung, spleen and thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SRXN1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
    Products:
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    OriGene qSTAR qPCR primer pairs in human, mouse for SRXN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRXN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRXN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SRXN1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srxn11 , 5 sulfiredoxin 1 homolog (S. cerevisiae)1, 5 86.27(n)1
    90.44(a)1
      2 (74.83 cM)5
    766501  NM_029688.51  NP_083964.21 
     1521055165 
    chicken
    (Gallus gallus)
    Aves SRXN11 sulfiredoxin 1 69.88(n)
    72.29(a)
      100858692  XM_004947150.1  XP_004947207.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srxn11 sulfiredoxin 1 homolog (S. cerevisiae) 59(n)
    61.95(a)
      100331561  XM_002663127.3  XP_002663173.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67621 CG6762 62.73(n)
    58.18(a)
      32768  NM_001201738.1  NP_001188667.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SRX1(YKL086W)4 Sulfiredoxin, contributes to oxidative stress resistance more   --   11(278281-278664) 853776  NP_012837.1 


    ENSEMBL Gene Tree for SRXN1 (if available)
    TreeFam Gene Tree for SRXN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRXN1 (see all 231)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018517651,2
    --626776(+) CGCAG-/TCTTTATT 1 -- cds10--------
    rs1860427341,2
    --626879(+) CCTCAA/GTCAGA 1 -- int10--------
    rs1161878851,2
    C,F--626891(+) ACTCTG/TGGGGG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs60852651,2
    C,F,A,H--626975(+) GTTTAG/CGACCA 1 -- int15Minor allele frequency- C:0.36NA WA 246
    rs1907049491,2
    --627085(+) GCCCCA/GGGAGG 1 -- int10--------
    rs1811675131,2
    --627119(+) CGTGCC/TACTGC 1 -- int10--------
    rs73609051,2
    C,F--627143(+) tgacaG/Aggcat 1 -- int13Minor allele frequency- A:0.06NA WA 122
    rs1446374751,2
    C--627159(+) GTCTC-/A/A   
      AAAAAA
    AAAAA
    1 -- int10--------
    rs560407711,2
    C--627170(+) AAAAAA/GAAAGT 1 -- int10--------
    rs664799361,2
    C--627259(+) CCCCC-/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SRXN1 (627259 - 634014 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SRXN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4512n71CNV Loss21882294
    nsv522812CNV Loss19592680
    nsv912573CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRXN1
    DNA2.0 Custom Variant and Variant Library Synthesis for SRXN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    10 diseases for SRXN1:    
    About MalaCards
    nonspecific interstitial pneumonia    idiopathic pulmonary fibrosis    pulmonary fibrosis    pneumonia
    acute myeloid leukemia    myeloid leukemia    lung cancer    hepatocellular carcinoma
    leukemia    breast cancer


    SRXN1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRXN1

    Export disorders for SRXN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRXN1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SRXN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. (PubMed id 15952770)1, 2, 9 Jonsson T.J.... Lowther W.T. (Biochemistry 2005)
    2. Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2- cys peroxiredoxins. (PubMed id 15590625)1, 2 Woo H.A....Rhee S.G. (J. Biol. Chem. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. (PubMed id 15448164)1, 2 Chang T.-S.... Rhee S.G. (J. Biol. Chem. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. (PubMed id 19561357)1, 9 Park J.W....Chock P.B. (J. Biol. Chem. 2009)
    7. Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. (PubMed id 18172504)1, 9 JAPnsson T.J....Lowther W.T. (Nature 2008)
    8. Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer. (PubMed id 22964583)1 Hartikainen J.M....Soini Y. (Cancer Res. 2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Nuclear factor erythroid-derived 2-like 2 (Nrf2) and DJ1 are prognostic factors in lung cancer. (PubMed id 21943684)1 Merikallio H....Soini Y. (Hum. Pathol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140809 HGNC: 16132 AceView: SCRT2andC20orf139 Ensembl:ENSG00000271303 euGenes: HUgn140809
    ECgene: SRXN1 H-InvDB: SRXN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRXN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRXN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRXN1 gene:
    Search GeneIP for patents involving SRXN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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