Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SRXN1 Gene

Aliases for SRXN1 Gene

  • Sulfiredoxin 1 2 3 5
  • C20orf139 3 4
  • SRX 3 4
  • Sulfiredoxin 1 Homolog (S. Cerevisiae) 2
  • Chromosome 20 Open Reading Frame 139 2
  • Sulfiredoxin-1 3
  • EC 1.8.98.2 4
  • Npn3 3
  • SRX1 3

External Ids for SRXN1 Gene

Previous HGNC Symbols for SRXN1 Gene

  • C20orf139

Previous GeneCards Identifiers for SRXN1 Gene

  • GC20M000577
  • GC20M000630

Summaries for SRXN1 Gene

GeneCards Summary for SRXN1 Gene

SRXN1 (Sulfiredoxin 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on a sulfur group of donors and sulfiredoxin activity.

UniProtKB/Swiss-Prot for SRXN1 Gene

  • Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

Gene Wiki entry for SRXN1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRXN1 Gene

Genomics for SRXN1 Gene

Regulatory Elements for SRXN1 Gene

Enhancers for SRXN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F000651 0.7 ENCODE 25.4 +0.3 331 2.7 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 SRXN1 GC20M000621
GH20F000645 1 Ensembl ENCODE 14.5 +7.1 7148 2.3 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 ZNF207 FOS SRXN1 TCF15 CSNK2A1 SCRT2 SLC52A3 GC20M000621 GC20M000631
GH20F000641 0.8 Ensembl ENCODE 12.9 +10.8 10808 2.0 PKNOX1 ARID4B DMAP1 ZNF48 SP5 NFYC PPARG KAT8 MIER3 GLIS1 SRXN1 TCF15 CSNK2A1 GC20M000631 GC20M000621
GH20F000727 0.8 Ensembl ENCODE 12.6 -75.1 -75086 1.3 ARID4B ZNF48 GLIS2 CBX5 ZNF143 ZNF263 SP5 MIER2 REST PPARG SCRT2 SRXN1 SLC52A3 CSNK2A1 ANGPT4 SOX12 GC20P000743 PIR59185
GH20F000699 0.6 ENCODE 12.3 -46.7 -46652 0.1 BCOR SMARCA5 ZMYM3 REST NR2F2 YY1 ZFHX2 SMARCA4 ATF3 ADNP SCRT2 SRXN1 SLC52A3 ANGPT4 PIR59185
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SRXN1 on UCSC Golden Path with GeneCards custom track

Promoters for SRXN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000396342 470 1801 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS

Genomic Location for SRXN1 Gene

Chromosome:
20
Start:
646,615 bp from pter
End:
653,370 bp from pter
Size:
6,756 bases
Orientation:
Minus strand

Genomic View for SRXN1 Gene

Genes around SRXN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRXN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRXN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRXN1 Gene

Proteins for SRXN1 Gene

  • Protein details for SRXN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYN0-SRXN1_HUMAN
    Recommended name:
    Sulfiredoxin-1
    Protein Accession:
    Q9BYN0
    Secondary Accessions:
    • B2R543
    • Q8NDM3
    • Q96AK6

    Protein attributes for SRXN1 Gene

    Size:
    137 amino acids
    Molecular mass:
    14259 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SRXN1 Gene

neXtProt entry for SRXN1 Gene

Post-translational modifications for SRXN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRXN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRXN1 Gene

Domains & Families for SRXN1 Gene

Protein Domains for SRXN1 Gene

Suggested Antigen Peptide Sequences for SRXN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYN0

UniProtKB/Swiss-Prot:

SRXN1_HUMAN :
  • Belongs to the sulfiredoxin family.
Family:
  • Belongs to the sulfiredoxin family.
genes like me logo Genes that share domains with SRXN1: view

No data available for Gene Families for SRXN1 Gene

Function for SRXN1 Gene

Molecular function for SRXN1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.
UniProtKB/Swiss-Prot Function:
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

Enzyme Numbers (IUBMB) for SRXN1 Gene

Gene Ontology (GO) - Molecular Function for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016209 antioxidant activity IEA --
GO:0016491 oxidoreductase activity IEA --
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors IDA 15448164
GO:0032542 sulfiredoxin activity IEA,IBA --
genes like me logo Genes that share ontologies with SRXN1: view
genes like me logo Genes that share phenotypes with SRXN1: view

Animal Models for SRXN1 Gene

MGI Knock Outs for SRXN1:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRXN1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRXN1 Gene

Localization for SRXN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRXN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRXN1 Gene COMPARTMENTS Subcellular localization image for SRXN1 gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 15448164
genes like me logo Genes that share ontologies with SRXN1: view

Pathways & Interactions for SRXN1 Gene

SuperPathways for SRXN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRXN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress IDA 15448164
GO:0034599 cellular response to oxidative stress IBA --
GO:0055114 oxidation-reduction process IEA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with SRXN1: view

No data available for Pathways by source and SIGNOR curated interactions for SRXN1 Gene

Drugs & Compounds for SRXN1 Gene

(1) Drugs for SRXN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with SRXN1: view

Transcripts for SRXN1 Gene

mRNA/cDNA for SRXN1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(234) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRXN1 Gene

Sulfiredoxin 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SRXN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRXN1 Gene

No ASD Table

Relevant External Links for SRXN1 Gene

GeneLoc Exon Structure for
SRXN1
ECgene alternative splicing isoforms for
SRXN1

Expression for SRXN1 Gene

mRNA expression in normal human tissues for SRXN1 Gene

Protein differential expression in normal tissues from HIPED for SRXN1 Gene

This gene is overexpressed in Bone (14.1) and Stomach (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRXN1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SRXN1 Gene:

SRXN1

SOURCE GeneReport for Unigene cluster for SRXN1 Gene:

Hs.516830

mRNA Expression by UniProt/SwissProt for SRXN1 Gene:

Q9BYN0-SRXN1_HUMAN
Tissue specificity: Widely expressed with highest levels in kidney, lung, spleen and thymus.
genes like me logo Genes that share expression patterns with SRXN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for SRXN1 Gene

Orthologs for SRXN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRXN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRXN1 34 35
  • 99.51 (n)
cow
(Bos Taurus)
Mammalia SRXN1 34 35
  • 90.51 (n)
dog
(Canis familiaris)
Mammalia SRXN1 34 35
  • 86.92 (n)
mouse
(Mus musculus)
Mammalia Srxn1 34 16 35
  • 86.27 (n)
rat
(Rattus norvegicus)
Mammalia Srxn1 34
  • 84.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRXN1 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRXN1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRXN1 34
  • 69.88 (n)
zebrafish
(Danio rerio)
Actinopterygii srxn1 34 35
  • 59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6762 34 35
  • 62.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRX1 35 37
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
Species where no ortholog for SRXN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRXN1 Gene

ENSEMBL:
Gene Tree for SRXN1 (if available)
TreeFam:
Gene Tree for SRXN1 (if available)

Paralogs for SRXN1 Gene

Pseudogenes.org Pseudogenes for SRXN1 Gene

genes like me logo Genes that share paralogs with SRXN1: view

No data available for Paralogs for SRXN1 Gene

Variants for SRXN1 Gene

Sequence variations from dbSNP and Humsavar for SRXN1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10427445 -- 653,602(+) AGCCC(A/C/G)CGGTG intron-variant, upstream-variant-2KB
rs10427447 -- 653,820(+) GTGAT(G/T)TACCC nc-transcript-variant, upstream-variant-2KB
rs111891682 -- 648,713(+) AGGCT(C/G)CTACT utr-variant-3-prime
rs111984579 -- 648,434(+) GGAGC(C/T)GGCAG utr-variant-3-prime
rs112409244 -- 646,722(+) CCTAC(C/T)CCAAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SRXN1 Gene

Variant ID Type Subtype PubMed ID
dgv7424n54 CNV loss 21841781
esv3644952 CNV gain 21293372
nsv522812 CNV loss 19592680
nsv585188 CNV gain 21841781

Variation tolerance for SRXN1 Gene

Gene Damage Index Score: 1.26; 25.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRXN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRXN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRXN1 Gene

Disorders for SRXN1 Gene

Relevant External Links for SRXN1

Genetic Association Database (GAD)
SRXN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRXN1

No disorders were found for SRXN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRXN1 Gene

Publications for SRXN1 Gene

  1. Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin. (PMID: 15952770) Jonsson T.J. … Lowther W.T. (Biochemistry 2005) 3 4 22 64
  2. Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. (PMID: 19561357) Park J.W. … Chock P.B. (J. Biol. Chem. 2009) 3 22 64
  3. Structure of the sulphiredoxin-peroxiredoxin complex reveals an essential repair embrace. (PMID: 18172504) JAPnsson T.J. … Lowther W.T. (Nature 2008) 3 22 64
  4. Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2- cys peroxiredoxins. (PMID: 15590625) Woo H.A. … Rhee S.G. (J. Biol. Chem. 2005) 3 4 64
  5. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. (PMID: 15448164) Chang T.-S. … Rhee S.G. (J. Biol. Chem. 2004) 3 4 64

Products for SRXN1 Gene

Sources for SRXN1 Gene

Content
Loading form....