Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SRSF9 Gene

protein-coding   GIFtS: 57
GCID: GC12M120900

Serine/Arginine-Rich Splicing Factor 9

(Previous names: splicing factor, arginine/serine-rich 9)
(Previous symbol: SFRS9)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine/Arginine-Rich Splicing Factor 91 2     Pre-MRNA-Splicing Factor SRp30C2 3
SFRS91 2 3 5     SRp30c2 5
Splicing Factor, Arginine/Serine-Rich 91 2 3     SRP30C3
SR Splicing Factor 91 2     

External Ids:    HGNC: 107911   Entrez Gene: 86832   Ensembl: ENSG000001117867   OMIM: 6019435   UniProtKB: Q132423   

Export aliases for SRSF9 gene to outside databases

Previous GC identifer: GC12M117908


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SRSF9 Gene:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,
which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for
binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues
and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA
splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. (provided by
RefSeq, Sep 2010)

GeneCards Summary for SRSF9 Gene:
SRSF9 (serine/arginine-rich splicing factor 9) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242
Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Represses the splicing of MAPT/Tau exon 10

Gene Wiki entry for SRSF9 (SFRS9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF9
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF9 promoter sequence
   Search Chromatin IP Primers for SRSF9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SRSF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF9 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M120900:  view genomic region     (about GC identifiers)

Start:
120,899,471 bp from pter      End:
120,907,596 bp from pter
Size:
8,126 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 9  
Size: 221 amino acids; 25542 Da
Subunit: Interacts with KHDRBS3 (By similarity). Interacts with NOL3/ARC/NOP30, NSEP1/YB-1/YB1, SAFB/SAFB1,
SRSF6/SFRS6, TRA2B/SFRS10 and C1QBP. May also interact with DUSP11/PIR1
Secondary accessions: Q52LD1

Explore the universe of human proteins at neXtProt for SRSF9: NX_Q13242

Explore proteomics data for SRSF9 at MOPED

Post-translational modifications: 

  • Extensively phosphorylated on serine residues in the RS domain (By similarity)1
  • Ubiquitination2 at Lys28, Lys36, Lys128, Lys144, Lys155
  • Modification sites at PhosphoSitePlus

  • See SRSF9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003760.1  
    ENSEMBL proteins: 
     ENSP00000229390   ENSP00000474283   ENSP00000449030  
    Reactome Protein details: Q13242

    SRSF9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SRSF9
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SRSF9
    GenScript Custom Purified and Recombinant Proteins Services for SRSF9
    Novus Biologicals SRSF9 Proteins
    Novus Biologicals SRSF9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRSF9

     
    Search eBioscience for Proteins for SRSF9 

    SRSF9 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRSF9
    Novus Biologicals SRSF9 Antibodies
    Abcam antibodies for SRSF9
    Cloud-Clone Corp. Antibodies for SRSF9
    ThermoFisher Antibodies for SRSF9
    LSBio Antibodies in human, mouse, rat for SRSF9

    SRSF9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRSF9
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRSF9
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRSF9
    Cloud-Clone Corp. CLIAs for SRSF9
    Search eBioscience for ELISAs for SRSF9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q13242

    ProtoNet protein and cluster: Q13242

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with SRSF9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF9_HUMAN, Q13242
    Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
    Represses the splicing of MAPT/Tau exon 10

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI19523114
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRSF9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SRSF9:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRSF9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRSF9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRSF9

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRSF9:
    hsa-mir-484 (MIRT041664), hsa-mir-935 (MIRT036696), hsa-mir-1 (MIRT005072), hsa-mir-30d-5p (MIRT047805)

    Block miRNA regulation of human, mouse, rat SRSF9 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SRSF9:
    hsa-miR-4303 hsa-miR-3673 hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSRSF9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRSF9
    Predesigned siRNA for gene silencing in human, mouse, rat SRSF9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRSF9

    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF9 (see all 6)
    OriGene ORF clones in mouse, rat for SRSF9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRSF9 (NM_003769)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF9

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRSF9
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRSF9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SRSF9_HUMAN, Q13242: Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete
    nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors
    including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may
    participate in the post-transcriptional regulation of mRNAs in stressed cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SRSF9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SRSF9 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SRSF9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF9
        mRNA processing

    4 Reactome Pathways for SRSF9
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


    2 Kegg Pathways  (Kegg details for SRSF9):
        Spliceosome
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF9
    Interactions:

        Search GeneGlobe Interaction Network for SRSF9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRSF9 (Q132421, 2, 3 ENSP000002293904) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HABP4Q5JVS01, 2, 3, ENSP000003643984EBI-2949710,EBI-523625 MINT-7041232 MINT-7041065 I2D: score=1 STRING: ENSP00000364398
    SF3A2Q154282, 3, ENSP000002214944MINT-5205728 I2D: score=1 STRING: ENSP00000221494
    C1QBPQ070213, ENSP000002256984I2D: score=3 STRING: ENSP00000225698
    TRA2BP629953, ENSP000004169594I2D: score=3 STRING: ENSP00000416959
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=2 STRING: ENSP00000363970
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006376mRNA splice site selection TAS7556075
    GO:0006397mRNA processing TAS7556075

    Find genes that share ontologies with SRSF9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SRSF9 gene: 
    NM_003769.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229390(uc001tyi.3) ENST00000548326 ENST00000548792 ENST00000603963
    ENST00000550458 ENST00000546942(uc009zwy.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRSF9 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SRSF9:
    hsa-miR-4303 hsa-miR-3673 hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-1291
    SwitchGear 3'UTR luciferase reporter plasmidSRSF9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRSF9
    Predesigned siRNA for gene silencing in human, mouse, rat SRSF9
    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF9 (see all 6)
    OriGene ORF clones in mouse, rat for SRSF9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRSF9 (NM_003769)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF9
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRSF9
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF9
      QuantiTect SYBR Green Assays in human, mouse, rat SRSF9
      Search QuantiFast Probe-based Assays in human, mouse, rat SRSF9

    Selected AceView cDNA sequences (see all 413):

    AA829897 CA396836 CK903352 BM011624 N75554 AI685114 BQ879920 CR617389 
    AW004780 BQ774015 AA010791 BM554930 AW163065 CR593564 BU173336 BM069843 
    BE785705 CR615364 AI372851 BF981478 BQ436494 BU632796 BQ955022 CR603096 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF9    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                    -     -                           
    SP2:              -     -     -                           
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for SRSF9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SRSF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGTGAAAC
    SRSF9 Expression
    About this image


    SRSF9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    SRSF9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF9 Protein Expression

    UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242
    Tissue specificity: Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in
    the brain, liver, lung and skeletal muscle

        Custom PCR Arrays for SRSF9
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRSF9
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF9
    QuantiTect SYBR Green Assays in human, mouse, rat SRSF9
    Search QuantiFast Probe-based Assays in human, mouse, rat SRSF9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRSF9 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf91 , 5 serine/arginine-rich splicing factor 91, 5 93.48(n)1
    98.64(a)1
      5 (56.05 cM)5
    1080141  NM_025573.31  NP_079849.11 
     1153271775 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF96
    serine/arginine-rich splicing factor 9
    79(a)
    1 ↔ 1
    GL343338.1(73961-86753)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA789729.12   -- 75.54(n)    CA789729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii srsf91 serine/arginine-rich splicing factor 9 64.9(n)
    68.6(a)
      405835  NM_212899.1  NP_998064.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SF26
    Rsf16
    Repressor splicing factor 1
    49(a)
    30(a)
    many ↔ many
    many ↔ many
    3R(12164665-12167706)
    2L(10261795-10263554)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-36
    Protein RSP-3 (rsp-3) mRNA, complete cds
    49(a)
    1 → many
    III(12686461-12687916) WBGene00004700
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NPL3(YDR432W)4 RNA-binding protein that promotes elongation, regulates more   --   4(1328783-1330027) 852042  NP_010720.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SRp34a1 SRp34a 56.26(n)
    56.69(a)
      824105  NM_001203112.1  NP_001190041.1 
    rice
    (Oryza sativa)
    Liliopsida AK071503.12   -- 76.61(n)    AK071503.1 


    ENSEMBL Gene Tree for SRSF9 (if available)
    TreeFam Gene Tree for SRSF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SRSF9 gene
    SRSF52  SRSF72  SRSF12  SRSF62  SRSF42  SRSF32  
    13 SIMAP similar genes for SRSF9 using alignment to 3 protein entries:     SRSF9_HUMAN (see all proteins):
    SRSF1    SRSF4    RALY    SFRS5    SRSF5    CIRBP
    SFRS6    G3BP1    RBMX    ELAVL1    SRSF6    SRSF7
    SFRS3

    Find genes that share paralogs with SRSF9           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for SRSF9
    PGOHUM00000246895 PGOHUM00000239077


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SRSF9 (see all 95)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881219361,2
    --117919397(+) TGCCTC/GCCACC 1 -- us2k10--------
    rs10501871,2
    C,F,A,H--120902111(-) CTCAAG/AGTGGT 1 -- int127Minor allele frequency- A:0.34EA MN NS NA CSA WA 4378
    rs1857393371,2
    --120902148(+) AGACCA/CGGCCT 1 -- int10--------
    rs5598381,2
    C,F--120902167(-) ACTTCT/CTGCTC 1 -- int12Minor allele frequency- C:0.06WA NA 238
    rs1900570661,2
    --120902210(+) TTCATA/GGCCTC 1 -- int10--------
    rs1460309811,2
    C--120902212(+) CATAG-/CCTCTT 1 -- int10--------
    rs5661241,2
    C,F,A,H--120902279(-) ATTTCA/GTAATG 1 -- int122Minor allele frequency- G:0.46NS EA NA WA CSA 2346
    rs1824682511,2
    C--120902317(+) ACAGGG/TTTTCA 1 -- int10--------
    rs791922631,2
    C,F--120902356(+) TGAAAT/AAACCA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs110651311,2
    C--120902516(+) CTAGTC/TGGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for SRSF9 (120899471 - 120907596 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SRSF9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2579823CNV Insertion19546169
    nsv509482CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF9
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601943    OMIM disorders: --


    Find genes that share disorders with SRSF9           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SRSF9 (0 documents)

    Export disorders for SRSF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SRSF9 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with SRSF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PubMed id 7556075)1, 2, 3, 9 Screaton G.R.... Krainer A.R. (EMBO J. 1995)
    2. SRp30c is a repressor of 3' splice site utilization. (PubMed id 12024014)1, 2, 9 Simard M.J. and Chabot B. (Mol. Cell. Biol. 2002)
    3. Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. (PubMed id 12604611)1, 2, 9 Raffetseder U.... Mertens P.R. (J. Biol. Chem. 2003)
    4. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. (PubMed id 10196175)1, 2, 9 Stoss O.... Stamm S. (J. Biol. Chem. 1999)
    5. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    7. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c SRp55 complex that either recruits or antagonizes htra2beta1. (PubMed id 15695522)1, 2 Wang Y.... Andreadis A. (J. Biol. Chem. 2005)
    10. Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. (PubMed id 15009090)1, 2 Kondo S....Imaizumi K. (Genes Cells 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8683 HGNC: 10791 AceView: SFRS9 Ensembl:ENSG00000111786 euGenes: HUgn8683
    ECgene: SRSF9 Kegg: 8683 H-InvDB: SRSF9

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SRSF9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SRSF9 gene:
    Search GeneIP for patents involving SRSF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SRSF9  
     OriGene qPCR primer pairs and template standards for SRSF9   OriGene Protein Over-expression Lysate for SRSF9  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SRSF9  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRSF9   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SRSF9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRSF9   OriGene Custom Protein Services for SRSF9  

     
     
     Block miRNA regulation of human, mouse, rat SRSF9 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SRSF9
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF9 Predesigned siRNA for gene silencing in human, mouse, rat SRSF9
     Search QuantiFast Probe-based Assays in human, mouse, rat SRSF9 QuantiTect SYBR Green Assays in human, mouse, rat SRSF9
     Custom PCR Arrays for SRSF9 Search Chromatin IP Primers for SRSF9
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF9  Search GeneGlobe Interaction Network for SRSF9
     Search Regulatory tfbs for SRSF9
     GenScript Custom Purified and Recombinant Proteins Services for SRSF9 GenScript cDNA clones with any tag delivered in your preferred vector for SRSF9
     GenScript Custom Assay Services for SRSF9 GenScript Custom overexpressing Cell Line Services for SRSF9
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SRSF9
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SRSF9 antibodies
     SRSF9 proteins
     SRSF9 lysates
     Antibodies for SRSF9
     See all of Abcam's Antibodies, Kits and Proteins for SRSF9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SRSF9
     Antibodies for SRSF9
     ELISAs for SRSF9
     CLIAs for SRSF9



     Browse ESI BIO Cell Lines and PureStem Progenitors for SRSF9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF9
     SwitchGear 3'UTR luciferase reporter plasmids for SRSF9
     SwitchGear Promoter luciferase reporter plasmids for SRSF9
     ThermoFisher Antibodies for SRSF9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF9
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF9
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRSF9
     LSBio Antibodies in human, mouse, rat for SRSF9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SRSF9
      Search eBioscience for proteins for SRSF9
      Search eBioscience for elisas for SRSF9
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRSF9 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4