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Aliases for SRSF9 Gene

Aliases for SRSF9 Gene

  • Serine/Arginine-Rich Splicing Factor 9 2 3
  • Splicing Factor, Arginine/Serine-Rich 9 2 3 4
  • SRp30c 3 4 6
  • SFRS9 3 4 6
  • Pre-MRNA-Splicing Factor SRp30C 3 4
  • SR Splicing Factor 9 2 3

External Ids for SRSF9 Gene

Previous HGNC Symbols for SRSF9 Gene

  • SFRS9

Previous GeneCards Identifiers for SRSF9 Gene

  • GC12M120900
  • GC12M117908

Summaries for SRSF9 Gene

Entrez Gene Summary for SRSF9 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF9 Gene

SRSF9 (Serine/Arginine-Rich Splicing Factor 9) is a Protein Coding gene. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF4.

UniProtKB/Swiss-Prot for SRSF9 Gene

  • Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for SRSF9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF9 Gene

Genomics for SRSF9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRSF9 Gene

120,461,668 bp from pter
120,469,793 bp from pter
8,126 bases
Minus strand

Genomic View for SRSF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF9 Gene

No data available for Regulatory Elements for SRSF9 Gene

Proteins for SRSF9 Gene

  • Protein details for SRSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/arginine-rich splicing factor 9
    Protein Accession:
    Secondary Accessions:
    • Q52LD1

    Protein attributes for SRSF9 Gene

    221 amino acids
    Molecular mass:
    25542 Da
    Quaternary structure:
    • Interacts with KHDRBS3 (By similarity). Interacts with NOL3/ARC/NOP30, NSEP1/YB-1/YB1, SAFB/SAFB1, SRSF6/SFRS6, TRA2B/SFRS10 and C1QBP. May also interact with DUSP11/PIR1.

neXtProt entry for SRSF9 Gene

Proteomics data for SRSF9 Gene at MOPED

Post-translational modifications for SRSF9 Gene

  • Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at Lys28, Lys36, Lys128, Lys144, and Lys155
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SRSF9 Gene

Domains for SRSF9 Gene

Gene Families for SRSF9 Gene

  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF9 Gene

Suggested Antigen Peptide Sequences for SRSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q13242
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF9: view

Function for SRSF9 Gene

Molecular function for SRSF9 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for SRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 10196175
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF9: view

Phenotypes for SRSF9 Gene

GenomeRNAi human phenotypes for SRSF9:
genes like me logo Genes that share phenotypes with SRSF9: view

Animal Model Products

CRISPR Products

miRNA for SRSF9 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRSF9 Gene

Localization for SRSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF9 Gene

Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.

Subcellular locations from

Jensen Localization Image for SRSF9 Gene COMPARTMENTS Subcellular localization image for SRSF9 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SRSF9: view

Pathways for SRSF9 Gene

genes like me logo Genes that share pathways with SRSF9: view

Gene Ontology (GO) - Biological Process for SRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006376 mRNA splice site selection TAS 7556075
GO:0006397 mRNA processing TAS 7556075
genes like me logo Genes that share ontologies with SRSF9: view

Transcripts for SRSF9 Gene

Unigene Clusters for SRSF9 Gene

Serine/arginine-rich splicing factor 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF9 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -

Relevant External Links for SRSF9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRSF9 Gene

mRNA expression in normal human tissues for SRSF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SRSF9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2), Nasal epithelium (6.9), and Fetal ovary (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF9 Gene

SOURCE GeneReport for Unigene cluster for SRSF9 Gene Hs.744094

mRNA Expression by UniProt/SwissProt for SRSF9 Gene

Tissue specificity: Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle.
genes like me logo Genes that share expressions with SRSF9: view

Expression partners for SRSF9 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SRSF9 Gene

Orthologs for SRSF9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRSF9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SRSF9 35
  • 96.23 (n)
  • 97.74 (a)
SFRS9 36
  • 98 (a)
(Canis familiaris)
Mammalia SRSF9 35
  • 96.68 (n)
  • 99.1 (a)
SRSF9 36
  • 99 (a)
(Mus musculus)
Mammalia Srsf9 35
  • 93.48 (n)
  • 98.64 (a)
Srsf9 16
Srsf9 36
  • 98 (a)
(Pan troglodytes)
Mammalia SRSF9 35
  • 100 (n)
  • 100 (a)
SRSF9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Srsf9 35
  • 90.2 (n)
  • 97.29 (a)
(Monodelphis domestica)
Mammalia SRSF9 36
  • 86 (a)
(Anolis carolinensis)
Reptilia SRSF9 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf9 35
  • 71.23 (n)
  • 79 (a)
Str.8004 35
(Danio rerio)
Actinopterygii srsf9 35
  • 64.9 (n)
  • 68.6 (a)
srsf9 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.98 35
fruit fly
(Drosophila melanogaster)
Insecta Rsf1 36
  • 30 (a)
SF2 36
  • 49 (a)
(Caenorhabditis elegans)
Secernentea rsp-3 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 36
  • 16 (a)
NPL3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SRp34a 35
  • 56.26 (n)
  • 56.69 (a)
(Triticum aestivum)
Liliopsida Ta.3227 35
(Zea mays)
Liliopsida Zm.10359 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1451 36
  • 55 (a)
CSA.5260 36
  • 56 (a)
Species with no ortholog for SRSF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SRSF9 Gene

Gene Tree for SRSF9 (if available)
Gene Tree for SRSF9 (if available)

Paralogs for SRSF9 Gene

Paralogs for SRSF9 Gene

Selected SIMAP similar genes for SRSF9 Gene using alignment to 3 proteins: Pseudogenes for SRSF9 Gene

genes like me logo Genes that share paralogs with SRSF9: view

Variants for SRSF9 Gene

Sequence variations from dbSNP and Humsavar for SRSF9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs485198 -- 120,465,952(-) CGTCT(C/T)CAAAC intron-variant
rs512688 -- 120,466,614(-) agctg(C/G)tgtga intron-variant
rs513786 -- 120,466,771(+) gctca(C/G)gcgat intron-variant
rs519058 -- 120,466,776(+) ggcga(G/T)ccttc intron-variant
rs559838 -- 120,464,364(-) ACTTC(C/T)TGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF9 Gene

Variant ID Type Subtype PubMed ID
nsv509482 CNV Insertion 20534489
esv2579823 CNV Insertion 19546169

Relevant External Links for SRSF9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF9 Gene

Disorders for SRSF9 Gene

Relevant External Links for SRSF9

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SRSF9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SRSF9 Gene

Publications for SRSF9 Gene

  1. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton G.R. … Krainer A.R. (EMBO J. 1995) 2 3 4 23
  2. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. (PMID: 10196175) Stoss O. … Stamm S. (J. Biol. Chem. 1999) 3 4 23
  3. SRp30c is a repressor of 3' splice site utilization. (PMID: 12024014) Simard M.J. … Chabot B. (Mol. Cell. Biol. 2002) 3 4 23
  4. Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. (PMID: 12604611) Raffetseder U. … Mertens P.R. (J. Biol. Chem. 2003) 3 4 23
  5. Serine-arginine-rich protein p30 directs alternative splicing of glucocorticoid receptor pre-mRNA to glucocorticoid receptor beta in neutrophils. (PMID: 12738786) Xu Q. … Kisich K.O. (J. Biol. Chem. 2003) 3 23

Products for SRSF9 Gene

Sources for SRSF9 Gene

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