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Aliases for SRSF9 Gene

Aliases for SRSF9 Gene

  • Serine And Arginine Rich Splicing Factor 9 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 9 2 3 4
  • Serine/Arginine-Rich Splicing Factor 9 2 3
  • Pre-MRNA-Splicing Factor SRp30C 3 4
  • SR Splicing Factor 9 2 3
  • SRp30c 3 4
  • SFRS9 3 4

External Ids for SRSF9 Gene

Previous HGNC Symbols for SRSF9 Gene

  • SFRS9

Previous GeneCards Identifiers for SRSF9 Gene

  • GC12M120900
  • GC12M117908

Summaries for SRSF9 Gene

Entrez Gene Summary for SRSF9 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF9 Gene

SRSF9 (Serine And Arginine Rich Splicing Factor 9) is a Protein Coding gene. Diseases associated with SRSF9 include Spinocerebellar Ataxia 31. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF1.

UniProtKB/Swiss-Prot for SRSF9 Gene

  • Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for SRSF9 Gene

Additional gene information for SRSF9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF9 Gene

Genomics for SRSF9 Gene

Regulatory Elements for SRSF9 Gene

Enhancers for SRSF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H120198 1.7 FANTOM5 ENCODE dbSUPER 21.6 +269.3 269342 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 GCN1 RAB35 RPL31P52 SRSF9 PRKAB1 ENSG00000256695 RPL12P33 LOC105370025 ENSG00000256963 ENSG00000201945
GH12H120290 1.5 ENCODE dbSUPER 21.6 +177.6 177564 3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A PPARGC1A GCN1 RPL31P52 RAB35 SRSF9 RPLP0 C12orf43 SIRT4 PRKAB1 PXN SPPL3
GH12H121398 1.5 FANTOM5 ENCODE 9.9 -930.5 -930533 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 SETD1B KDM2B ENSG00000258435 LINC01089 PSMD9 ANAPC5 ENSG00000272849 SRSF9 ORAI1 RNF34
GH12H121351 1.2 ENCODE 12 -882.6 -882592 2 HNRNPUL1 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ANAPC5 SETD1B PSMD9 CAMKK2 RNF34 SRSF9 ENSG00000272849 ENSG00000258435
GH12H120430 1.2 Ensembl ENCODE 11.1 +39.2 39230 0 ATF1 ARID4B SIN3A ZNF2 CBX5 ZNF207 ZNF143 KLF7 ATF7 RUNX3 RPS27P25 MSI1 RPL31P52 PLA2G1B DYNLL1 SRSF9 RNU6-1088P SIRT4 PXN COX6A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRSF9 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058315 493 2201 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 REST

Genomic Location for SRSF9 Gene

Chromosome:
12
Start:
120,461,668 bp from pter
End:
120,469,793 bp from pter
Size:
8,126 bases
Orientation:
Minus strand

Genomic View for SRSF9 Gene

Genes around SRSF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF9 Gene

Proteins for SRSF9 Gene

  • Protein details for SRSF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13242-SRSF9_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 9
    Protein Accession:
    Q13242
    Secondary Accessions:
    • Q52LD1

    Protein attributes for SRSF9 Gene

    Size:
    221 amino acids
    Molecular mass:
    25542 Da
    Quaternary structure:
    • Interacts with KHDRBS3 (By similarity). Interacts with NOL3/ARC/NOP30, NSEP1/YB-1/YB1, SAFB/SAFB1, SRSF6/SFRS6, TRA2B/SFRS10 and C1QBP. May also interact with DUSP11/PIR1.

neXtProt entry for SRSF9 Gene

Post-translational modifications for SRSF9 Gene

  • Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at Lys28, Lys36, posLast=128128, Lys144, and posLast=155155
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRSF9 Gene

Domains & Families for SRSF9 Gene

Gene Families for SRSF9 Gene

Protein Domains for SRSF9 Gene

Suggested Antigen Peptide Sequences for SRSF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13242

UniProtKB/Swiss-Prot:

SRSF9_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF9: view

Function for SRSF9 Gene

Molecular function for SRSF9 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for SRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 10196175
GO:0019904 protein domain specific binding IPI 10749975
genes like me logo Genes that share ontologies with SRSF9: view

Phenotypes for SRSF9 Gene

genes like me logo Genes that share phenotypes with SRSF9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SRSF9

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF9 Gene

Localization for SRSF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF9 Gene

Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF9 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with SRSF9: view

Pathways & Interactions for SRSF9 Gene

genes like me logo Genes that share pathways with SRSF9: view

Pathways by source for SRSF9 Gene

Gene Ontology (GO) - Biological Process for SRSF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006376 mRNA splice site selection TAS 7556075
GO:0006397 mRNA processing TAS 7556075
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF9: view

No data available for SIGNOR curated interactions for SRSF9 Gene

Drugs & Compounds for SRSF9 Gene

No Compound Related Data Available

Transcripts for SRSF9 Gene

Unigene Clusters for SRSF9 Gene

Serine/arginine-rich splicing factor 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF9 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for SRSF9 Gene

GeneLoc Exon Structure for
SRSF9
ECgene alternative splicing isoforms for
SRSF9

Expression for SRSF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.2), Nasal epithelium (6.9), and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF9 Gene



Protein tissue co-expression partners for SRSF9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF9 Gene:

SRSF9

SOURCE GeneReport for Unigene cluster for SRSF9 Gene:

Hs.744094

mRNA Expression by UniProt/SwissProt for SRSF9 Gene:

Q13242-SRSF9_HUMAN
Tissue specificity: Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle.

Evidence on tissue expression from TISSUES for SRSF9 Gene

  • Nervous system(4.6)
  • Intestine(4.4)
  • Liver(4.4)
  • Blood(4.3)
genes like me logo Genes that share expression patterns with SRSF9: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF9 Gene

Orthologs for SRSF9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRSF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF9 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia SFRS9 34
  • 98 (a)
OneToOne
SRSF9 33
  • 96.23 (n)
dog
(Canis familiaris)
Mammalia SRSF9 33 34
  • 96.68 (n)
mouse
(Mus musculus)
Mammalia Srsf9 33 16 34
  • 93.48 (n)
rat
(Rattus norvegicus)
Mammalia Srsf9 33
  • 90.2 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF9 34
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF9 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf9 33
  • 71.23 (n)
Str.8004 33
zebrafish
(Danio rerio)
Actinopterygii srsf9 33 34
  • 64.9 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.98 33
fruit fly
(Drosophila melanogaster)
Insecta SF2 34
  • 49 (a)
ManyToMany
Rsf1 34
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-3 34
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 34 36
  • 16 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SRp34a 33
  • 56.26 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.3227 33
corn
(Zea mays)
Liliopsida Zm.10359 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5260 34
  • 56 (a)
ManyToMany
CSA.1451 34
  • 55 (a)
ManyToMany
Species where no ortholog for SRSF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SRSF9 Gene

ENSEMBL:
Gene Tree for SRSF9 (if available)
TreeFam:
Gene Tree for SRSF9 (if available)

Paralogs for SRSF9 Gene

Paralogs for SRSF9 Gene

(13) SIMAP similar genes for SRSF9 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SRSF9 Gene

genes like me logo Genes that share paralogs with SRSF9: view

Variants for SRSF9 Gene

Sequence variations from dbSNP and Humsavar for SRSF9 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000172043 -- 120,471,504(+) CACCC(A/G)CATAT intron-variant, upstream-variant-2KB
rs1000204532 -- 120,471,138(+) GTGGG(C/T)GGATC intron-variant, upstream-variant-2KB
rs1000479288 -- 120,465,871(+) GCATG(A/C)GTAGT intron-variant
rs1001055406 -- 120,469,239(+) CGAAG(A/G)ACGGC intron-variant, upstream-variant-2KB
rs1001077511 -- 120,467,369(+) GGCAT(C/T)GCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF9 Gene

Variant ID Type Subtype PubMed ID
esv2579823 CNV insertion 19546169
nsv1069702 CNV deletion 25765185
nsv1145631 CNV deletion 24896259
nsv509482 CNV insertion 20534489
nsv983370 CNV duplication 23825009

Variation tolerance for SRSF9 Gene

Residual Variation Intolerance Score: 41.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF9 Gene

Disorders for SRSF9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRSF9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia 31
  • spinocerebellar ataxia type 31
- elite association - COSMIC cancer census association via MalaCards
Search SRSF9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRSF9

Human Genome Epidemiology (HuGE) Navigator
SRSF9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF9
genes like me logo Genes that share disorders with SRSF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF9 Gene

Publications for SRSF9 Gene

  1. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton GR … Krainer AR (The EMBO journal 1995) 2 3 4 22 60
  2. Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. (PMID: 12604611) Raffetseder U … Mertens PR (The Journal of biological chemistry 2003) 3 4 22 60
  3. SRp30c is a repressor of 3' splice site utilization. (PMID: 12024014) Simard MJ … Chabot B (Molecular and cellular biology 2002) 3 4 22 60
  4. Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. (PMID: 10196175) Stoss O … Stamm S (The Journal of biological chemistry 1999) 3 4 22 60
  5. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 60

Products for SRSF9 Gene

Sources for SRSF9 Gene

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