SRSF9 Gene
protein-coding GIFtS: 55
GCID: GC12M120900
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serine/arginine-rich splicing factor 9(Previous names: splicing factor, arginine/serine-rich 9 ) (Previous symbol: SFRS9)
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Aliases for SRSF9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Serine/Arginine-Rich Splicing Factor 91 2 | | Pre-MRNA-Splicing Factor SRp30C2 3 | | Splicing Factor, Arginine/Serine-Rich 91 2 3 | | SR Splicing Factor 92 | | SFRS91 2 3 | | SRP30C3 | | SRp30c1 2 | | |
Export aliases for SRSF9 gene to outside databasesPrevious GC identifer: GC12M117908 |
Summaries for SRSF9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SRSF9: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for bindingRNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitatesinteraction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteinshave also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one onchromosome 15 and the other on chromosome 21, have been found for this gene. (provided by RefSeq, Sep 2010) UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Repressesthe splicing of MAPT/Tau exon 10 Gene Wiki entry for SRSF9 (SFRS9)
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Genomic Views for SRSF9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for SRSF9 Other transcription factors
Search SABiosciences Chromatin IP Primers for SRSF9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF9 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31SRSF9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M120900: view genomic region
(about GC identifiers)
Start:
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120,899,471 bp from pter |
End:
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120,907,596 bp from pter |
Size:
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8,126 bases |
Orientation:
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minus strand |
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Proteins for SRSF9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242 (See
protein sequence)Recommended Name: Serine/arginine-rich splicing factor 9 Size: 221 amino acids; 25542 Da
Subunit: Interacts with KHDRBS3 (By similarity). Interacts with NOL3/ARC/NOP30, NSEP1/YB-1/YB1, SAFB/SAFB1,SRSF6/SFRS6, TRA2B/SFRS10 and C1QBP. May also interact with DUSP11/PIR1
Subcellular location: Nucleus. Note=Cellular stresses such as heat shock may induce localization to discrete nuclearbodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors includingSRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in thepost-transcriptional regulation of mRNAs in stressed cells
Secondary accessions: Q52LD1Explore the universe of human proteins at neXtProt for SRSF9: NX_Q13242
Post-translational modifications:
Extensively phosphorylated on serine residues in the RS domain (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13242 SRSF9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003760.1 ENSEMBL proteins: ENSP00000229390 ENSP00000449030 Reactome Protein details: Q13242 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SRSF9 for ontologies About GeneDecksing
SRSF9 Antibody Products: Assay Products for SRSF9: |
Protein
Domains / Families for SRSF9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRSF9 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13242ProtoNet protein and cluster: Q13242 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242Similarity: Belongs to the splicing factor SR familySimilarity: Contains 2 RRM (RNA recognition motif) domains |
Function for SRSF9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Repressesthe splicing of MAPT/Tau exon 10
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF9 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRSF9 (NM_003769) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRSF9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF9  |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
SRSF9 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SRSF9:
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Pathways & Interactions for SRSF9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | | | 2 | RNA Polymerase II Transcription Termination | | | 3 | Transcription | | | 4 | Transport of Mature Transcript to Cytoplasm | | | 5 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for SRSF9 
5/14
Reactome Pathways for SRSF9 (see all 14)
1
Kegg Pathway (Kegg details for SRSF9):
SRSF9 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF9
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/137 Interacting proteins for SRSF9 (Q132422, 3 ENSP000002293904) via UniProtKB, MINT, STRING, and/or I2D (see all 137)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
SRSF9 for ontologies About GeneDecksing
|
Drugs & Compounds for SRSF9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SRSF9 Search CenterWatch for drugs/clinical trials and news about SRSF9 
|
Transcripts for SRSF9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SRSF9 gene: NM_003769.2 Unigene Cluster for SRSF9: Serine/arginine-rich splicing factor 9 Hs.744094 [show with all ESTs]Unigene Representative Sequence: BG1076955 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000229390(uc001tyi.3) ENST00000548326 ENST00000548792 ENST00000550458 ENST00000546942(uc009zwy.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF9 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRSF9 (NM_003769) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRSF9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF9  |
Additional cDNA sequence: AK290644.1 AK294254.1 AK309778.1 BC093971.1 BC093973.1 U30825.1 11 DOTS entries: DT.99965724 DT.443296 DT.97855918 DT.419056 DT.121180209 DT.100645995 DT.100883530 DT.92448987 DT.95168853 DT.101954829 DT.102838255 24/413 AceView cDNA sequences (see all 413): BQ440462 BQ955022 CR616096 N75554 AA877919 CR591670 AI685114 W69647 BQ062282 CR606248 CB266536 BQ957723 CB529251 BQ879920 CR617389 BM806464 AI554406 BQ231323 BM011624 AU119724 CR598070 AI990128 BF002679 AW004780 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF9 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for SRSF9
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Expression for SRSF9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRSF9 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGGGTGAAAC
About this image See SRSF9 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SRSF9
SOURCE GeneReport for Unigene cluster: Hs.744094 UniProtKB/Swiss-Prot: SRSF9_HUMAN, Q13242Tissue specificity: Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in thebrain, liver, lung and skeletal muscle SABiosciences Custom PCR Arrays for SRSF9
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF9 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRSF9 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF9 | |  | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF9 |
Orthologs for SRSF9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SRSF9 gene from 7/28 species (see all 28) About this table
ENSEMBL Gene Tree for SRSF9 (if available) TreeFam Gene Tree for SRSF9 (if available)  |
Paralogs for SRSF9 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for SRSF9 gene
- LOC1009966572 SRSF42 SRSF122 SRSF102 SRSF52 SRSF22 SRSF72 SRSF12
- SRSF62 SRSF32
12 SIMAP similar genes for SRSF9 using alignment to 2 protein entries: SRSF9_HUMAN (see all proteins):SRSF1 SFRS5 SRSF5 SFRS6 SRSF4 CIRBP RBMX ELAVL1 SFRS3 SRSF7 SRSF6 SFRS4
SRSF9 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for SRSF9 PGOHUM00000246895 PGOHUM00000239077
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Genomic Variants for SRSF9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 12 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for SRSF9 (120899471 - 120907596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SRSF9: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF9 |
|
Disorders
/ Diseases for SRSF9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRSF9 for disorders About GeneDecksing
OMIM gene information: 601943
OMIM disorders: --
13 diseases for SRSF9: About MalaCardsopen-angle glaucoma distal hereditary motor neuropathy primary open angle glaucoma frontotemporal dementia glaucoma bipolar disorder neurodegenerative disease dementia neuropathy prostate cancer prostatitis malaria neuronitis Human Genome Epidemiology (HuGE) Navigator: SRSF9 (0 documents) Export disorders for SRSF9 gene to outside databases
|
Publications for SRSF9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRSF9 gene, integrated from 9 sources (see all 60): (articles sorted by number of sources associating them with SRSF9) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PubMed id 7556075)1, 2, 3, 9 Screaton G.R.... Krainer A.R. (1995)
- SRp30c is a repressor of 3' splice site utilization. (PubMed id 12024014)1, 2, 9 Simard M.J. and Chabot B. (2002)
- Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection. (PubMed id 12604611)1, 2, 9 Raffetseder U.... Mertens P.R. (2003)
- Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. (PubMed id 10196175)1, 2, 9 Stoss O.... Stamm S. (1999)
- A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Tau exons 2 and 10, which are misregulated in neurodegenerative diseases, are partly regulated by silencers which bind a SRp30c SRp55 complex that either recruits or antagonizes htra2beta1. (PubMed id 15695522)1, 2 Wang Y.... Andreadis A. (2005)
- Tra2 beta, SF2/ASF and SRp30c modulate the function of an exonic splicing enhancer in exon 10 of tau pre-mRNA. (PubMed id 15009090)1, 2 Kondo S....Imaizumi K. (2004)
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External Searches for SRSF9 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SRSF9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRSF9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRSF9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SRSF9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRSF9 gene: Search GeneIP for patents involving SRSF9
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SRSF9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF9 |
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