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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF8 Gene

protein-coding   GIFtS: 48
GCID: GC11P094801

Serine/Arginine-Rich Splicing Factor 8

(Previous names: splicing factor, arginine/serine-rich 2B)
(Previous symbol: SFRS2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Arginine-Rich Splicing Factor 81 2     Pre-MRNA-Splicing Factor SRP462 3
Splicing Factor, Arginine/Serine-Rich 2B1 2 3     Splicing Factor SRp462 3
SFRS2B1 2 3     DSM-12
SRP462 3 5     Splicing Factor, Arginine/Serine-Rich, 46kD2
SR Splicing Factor 81 2     

External Ids:    HGNC: 169881   Entrez Gene: 109292   Ensembl: ENSG000001807717   OMIM: 6032695   UniProtKB: Q9BRL63   

Export aliases for SRSF8 gene to outside databases

Previous GC identifer: GC11P090864


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF8 Gene:
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and
a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing
factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for SRSF8 Gene: 
SRSF8 (serine/arginine-rich splicing factor 8) is a protein-coding gene. Diseases associated with SRSF8 include melanoma, and prostatitis, and among its related super-pathways are Influenza A and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6
Function: Involved in pre-mRNA alternative splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF8
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SRSF8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q22

SRSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P094801:  view genomic region     (about GC identifiers)

Start:
94,800,056 bp from pter      End:
94,804,388 bp from pter
Size:
4,333 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 8  
Size: 282 amino acids; 32288 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for SRSF8:
2DNM (3D)    
Secondary accessions: B2R6B8 Q6PF01 Q96TA3
Alternative splicing: 2 isoforms:  Q9BRL6-1   Q9BRL6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF8: NX_Q9BRL6

Explore proteomics data for SRSF8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRL6

  • SRSF8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRSF8 Protein Expression
    REFSEQ proteins: NP_115285.1  
    Human Recombinant Protein Products for SRSF8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Cloud-Clone Corp. Proteins for SRSF8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    SRSF8 for ontologies           About GeneDecksing



    SRSF8 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9BRL6

    ProtoNet protein and cluster: Q9BRL6

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SRSF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF8_HUMAN, Q9BRL6
    Function: Involved in pre-mRNA alternative splicing

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
         
    SRSF8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRSF8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRSF8 
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF8:
    hsa-miR-576-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSRSF8 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRSF8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Herpes simplex infection0.33
    2mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for SRSF8):
        Spliceosome
    Herpes simplex infection


    SRSF8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF8

    3 Interacting proteins for SRSF8 (Q9BRL61, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SREK1Q8WXA93I2D: score=1 
    SRPK1Q96SB41EBI-6380719,EBI-539478
    SRPK2P783621EBI-6380719,EBI-593303
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    SRSF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF8

    Search CenterWatch for drugs/clinical trials and news about SRSF8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRSF8 gene: 
    NM_032102.3  

    Unigene Clusters for SRSF8:

    Serine/arginine-rich splicing factor 8
    Hs.476680  [show with all ESTs], Hs.703293  [show with all ESTs]
    Unigene Representative Sequences: NM_032102, BX440854
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000446101(uc001pff.3)
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF8:
    hsa-miR-576-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSRSF8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Sirion Biotech Customized lentivirus for stable overexpression of SRSF8 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF8
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    Additional mRNA sequence: AJ270685.1 

    11 DOTS entries:

    DT.75164423  DT.101963522  DT.97777649  DT.109468  DT.95317939  DT.120728477  DT.92461020  DT.92461043 
    DT.120728479  DT.92060821  DT.120728476 

    24/205 AceView cDNA sequences (see all 205):

    BF445759 BE908225 BF434236 AW152113 BM311298 AI913566 CA420471 AI613013 
    AI201483 AW001874 AI608751 BE672973 AW293089 CD108251 AI985549 BE504491 
    CR623195 AA731179 AI523729 BI822097 BQ186489 BU625474 BQ269580 AI052081 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGAGTT
    SRSF8 Expression
    About this image


    See SRSF8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF8

    SOURCE GeneReport for Unigene clusters: Hs.476680 Hs.703293

    UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6
    Tissue specificity: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and
    thymus

        SABiosciences Custom PCR Arrays for SRSF8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for SRSF8 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia SRSF81 serine/arginine-rich splicing factor 8 99.65(n)
    99.65(a)
      738544  XM_001139465.2  XP_001139465.2 


    ENSEMBL Gene Tree for SRSF8 (if available)
    TreeFam Gene Tree for SRSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF8 gene
    7 SIMAP similar genes for SRSF8 using alignment to 1 protein entry:     SRSF8_HUMAN:
    SRSF2    LOC346472    LOC392896    SFRS2    SRSF10    SRSF12
    SFRS4

    SRSF8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/51 SNPs in SRSF8 are shown (see all 51)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3759467811,2
    C--94800528(+) ATCCCA/GCGGGA 2 P syn10--------
    rs1440165941,2
    C--94800781(+) GGCGGA/CGACAC 2 R syn10--------
    rs1485099381,2
    C--94801365(+) TTTCTA/GCCTTT 1 -- ut310--------
    rs40194051,2
    C--94803531(-) ttttt-/T/TT  
            
    nngag
    2 -- ut311NA 2
    rs3740526661,2
    ----94800517(+) GCGACC/GTGTAC 2 L V mis10--------
    rs3716241411,2
    ----94800513(+) GTGGGC/TGACGT 2 G syn10--------
    rs32041681,2
    ----94804378(+) CTGTTA/CTATTG 1 -- ut310--------
    rs3746977191,2
    ----94803555(+) AAAAGA/GAAAAA 1 -- ut310--------
    rs3680194921,2
    ----94801276(+) GGACTC/TGGGGG 1 -- ut310--------
    rs3748588031,2
    ----94800829(+) GCAGCC/GGATCT 2 R G mis10--------

    HapMap Linkage Disequilibrium report for SRSF8 (94800056 - 94804388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRSF8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv898188CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SRSF8
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603269    OMIM disorders: --

    2 diseases for SRSF8:    About MalaCards
    melanoma    prostatitis


    SRSF8 for disorders           About GeneDecksing


    Export disorders for SRSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF8 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SRSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. (PubMed id 9671500)1, 2, 3, 9 Soret J....Perbal B. (1998)
    2. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    5. The P-body component USP52/PAN2 is a novel regulator o f HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (2013)
    6. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10929 HGNC: 16988 AceView: SRP46 Ensembl:ENSG00000180771 euGenes: HUgn10929
    ECgene: SRSF8 Kegg: 10929 H-InvDB: SRSF8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRSF8 gene:
    Search GeneIP for patents involving SRSF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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