SRSF8 Gene
protein-coding GIFtS: 46
GCID: GC11P094801
|
|
serine/arginine-rich splicing factor 8(Previous names: splicing factor, arginine/serine-rich 2B )
(Previous symbol: SFRS2B)
| |
Aliases
for SRSF8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Arginine-Rich Splicing Factor 81 2 | | Pre-MRNA-Splicing Factor SRP462 3 | | SRP461 2 3 5 | | Splicing Factor SRp462 3 | | Splicing Factor, Arginine/Serine-Rich 2B1 2 3 | | Splicing Factor, Arginine/Serine-Rich, 46kD2 | | SFRS2B1 2 3 | | SR Splicing Factor 82 |
Export aliases for SRSF8 gene to outside databasesPrevious GC identifer: GC11P090864 |
Summaries
for SRSF8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SRSF8:
The SR (serine/arginine-rich) family contains a number of phosphoproteins that function as essential and alternativesplicing factors. The SR family of proteins is characterized by the presence of a ribonucleoprotein (RNP)-type RNAbinding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The protein encoded by this gene is a memberof the SR family and functions as an essential splicing factor in vitro. This gene is thought to be an expressedPR264/SC35 retropseudogene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6Function: Involved in pre-mRNA alternative splicing
|
Genomic Views
for SRSF8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SRSF8
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRSF8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q22SRSF8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P094801: view genomic region
(about GC identifiers)
Start:
|
94,800,056 bp from pter |
End:
|
94,804,388 bp from pter |
Size:
|
4,333 bases |
Orientation:
|
plus strand |
|
Proteins
for SRSF8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6 (See
protein sequence)Recommended Name: Serine/arginine-rich splicing factor 8 Size: 282 amino acids; 32288 Da
Subcellular location: Nucleus
1 PDB 3D structure from  and Proteopedia  for SRSF8:2DNM (3D)
Secondary accessions: B2R6B8 Q6PF01 Q96TA3Alternative splicing: 2 isoforms: Q9BRL6-1 Q9BRL6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SRSF8: NX_Q9BRL6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRL6
SRSF8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115285.1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SRSF8 for ontologies About GeneDecksing
SRSF8 Antibody Products:
Assay Products for SRSF8: |
Protein
Domains /
Families
for SRSF8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRSF8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BRL6ProtoNet protein and cluster: Q9BRL6 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6Similarity: Belongs to the splicing factor SR familySimilarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for SRSF8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6Function: Involved in pre-mRNA alternative splicing
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRSF8 (NM_032102) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRSF8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- |
SRSF8 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SRSF8:
|
Pathways & Interactions
for SRSF8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for SRSF8):
SRSF8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF8
1 Interacting protein for SRSF8 (Q9BRL63) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
SRSF8 for ontologies About GeneDecksing
|
Drugs & Compounds
for SRSF8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRSF8
Search CenterWatch for drugs/clinical trials and news about SRSF8
|
Transcripts
for SRSF8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRSF8 gene: NM_032102.2 Unigene Clusters for SRSF8: Serine/arginine-rich splicing factor 8 Hs.476680 [show with all ESTs], Hs.703293 [show with all ESTs]Unigene Representative Sequences: NM_032102, BX4408543 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000529911 ENST00000531139 ENST00000446101(uc001pff.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRSF8 (NM_032102) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRSF8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF8 |
Additional cDNA sequence: AJ270685.1 11 DOTS entries: DT.75164423 DT.101963522 DT.97777649 DT.109468 DT.95317939 DT.120728477 DT.92461020 DT.92461043 DT.120728479 DT.92060821 DT.120728476 24/205 AceView cDNA sequences (see all 205): CA941600 AW152113 AI913566 CA420471 BE908225 AW293089 BQ269580 BI822097 AI608751 AI052081 AW001874 AA731179 BF514256 BQ186489 CD108251 BE504491 AI985549 BE672973 AI523729 AI613013 BM311298 BQ220644 AI201483 CR611239
GeneLoc Exon Structure
|
Expression
for SRSF8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRSF8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCTGAGTT
About this image
See SRSF8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRSF8
SOURCE GeneReport for Unigene clusters: Hs.476680 Hs.703293
UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6Tissue specificity: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus
SABiosciences Custom PCR Arrays for SRSF8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SRSF8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF8 |
Orthologs
for SRSF8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SRSF8 (if available)
TreeFam Gene Tree for SRSF8 (if available) |
Paralogs
for SRSF8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SRSF8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SRSF8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRSF8 for disorders About GeneDecksing
OMIM gene information: 603269
OMIM disorders: --
2  diseases for SRSF8: About MalaCardsmelanoma prostatitis
Export disorders for SRSF8 gene to outside databases
|
Publications
for SRSF8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRSF8 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with SRSF8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. (PubMed id 9671500)1, 2, 3, 9 Soret J....Perbal B. (1998)
- A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements. (PubMed id 17361132)1 Lareau L.F....Brenner S.E. (2007)
|
External Searches for SRSF8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRSF8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRSF8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRSF8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRSF8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRSF8 gene:
Search GeneIP for patents involving SRSF8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRSF8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SRSF8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRSF8 | | OriGene 3'-UTR Clone for SRSF8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRSF8 | | OriGene Custom Protein Services for SRSF8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRSF8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF8 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SRSF8 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SRSF8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF8 |
|  |  |  | | | | Search ThermoFisher Antibodies for SRSF8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF8 |
|
|
|
|
