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Aliases for SRSF8 Gene

Aliases for SRSF8 Gene

  • Serine/Arginine-Rich Splicing Factor 8 2 3
  • Splicing Factor, Arginine/Serine-Rich 2B 2 3 4
  • SFRS2B 3 4 6
  • SRP46 3 4 6
  • Pre-MRNA-Splicing Factor SRP46 3 4
  • SR Splicing Factor 8 2 3
  • Splicing Factor, Arginine/Serine-Rich, 46kD 3
  • Splicing Factor SRp46 4
  • DSM-1 3

External Ids for SRSF8 Gene

Previous HGNC Symbols for SRSF8 Gene

  • SFRS2B

Previous GeneCards Identifiers for SRSF8 Gene

  • GC11P094801
  • GC11P090864

Summaries for SRSF8 Gene

Entrez Gene Summary for SRSF8 Gene

  • This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for SRSF8 Gene

SRSF8 (Serine/Arginine-Rich Splicing Factor 8) is a Protein Coding gene. Among its related pathways are Influenza A and Spliceosome. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for SRSF8 Gene

  • Involved in pre-mRNA alternative splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF8 Gene

Genomics for SRSF8 Gene

Genomic Location for SRSF8 Gene

Start:
95,066,877 bp from pter
End:
95,071,224 bp from pter
Size:
4,348 bases
Orientation:
Plus strand

Genomic View for SRSF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF8 Gene

No data available for Regulatory Elements for SRSF8 Gene

Proteins for SRSF8 Gene

  • Protein details for SRSF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRL6-SRSF8_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 8
    Protein Accession:
    Q9BRL6
    Secondary Accessions:
    • B2R6B8
    • Q6PF01
    • Q96TA3

    Protein attributes for SRSF8 Gene

    Size:
    282 amino acids
    Molecular mass:
    32288 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SRSF8 Gene

    Alternative splice isoforms for SRSF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF8 Gene

Proteomics data for SRSF8 Gene at MOPED

Post-translational modifications for SRSF8 Gene

  • Ubiquitination at Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRSF8 Gene

Domains for SRSF8 Gene

Gene Families for SRSF8 Gene

HGNC:
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF8 Gene

Suggested Antigen Peptide Sequences for SRSF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRL6

UniProtKB/Swiss-Prot:

SRSF8_HUMAN :
  • Q9BRL6
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF8: view

Function for SRSF8 Gene

Molecular function for SRSF8 Gene

UniProtKB/Swiss-Prot Function: Involved in pre-mRNA alternative splicing.

Gene Ontology (GO) - Molecular Function for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 23602568
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF8: view

Phenotypes for SRSF8 Gene

GenomeRNAi human phenotypes for SRSF8:
genes like me logo Genes that share phenotypes with SRSF8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SRSF8 Gene

Localization for SRSF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF8 Gene COMPARTMENTS Subcellular localization image for SRSF8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with SRSF8: view

Pathways for SRSF8 Gene

SuperPathways for SRSF8 Gene

Superpath Contained pathways
1 Influenza A
2 Spliceosome
genes like me logo Genes that share pathways with SRSF8: view

Pathways by source for SRSF8 Gene

2 KEGG pathways for SRSF8 Gene

Interacting Proteins for SRSF8 Gene

Selected Interacting proteins: Q9BRL6-SRSF8_HUMAN for SRSF8 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for SRSF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SRSF8: view

Transcripts for SRSF8 Gene

mRNA/cDNA for SRSF8 Gene

(205) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRSF8 Gene

Serine/arginine-rich splicing factor 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF8 Gene

No ASD Table

Relevant External Links for SRSF8 Gene

GeneLoc Exon Structure for
SRSF8
ECgene alternative splicing isoforms for
SRSF8

Expression for SRSF8 Gene

mRNA expression in normal human tissues for SRSF8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SRSF8 Gene

SOURCE GeneReport for Unigene cluster for SRSF8 Gene Hs.476680

mRNA Expression by UniProt/SwissProt for SRSF8 Gene

Q9BRL6-SRSF8_HUMAN
Tissue specificity: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus.
genes like me logo Genes that share expressions with SRSF8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SRSF8 Gene

Orthologs for SRSF8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SRSF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF8 35
  • 99.65 (n)
  • 99.65 (a)
Species with no ortholog for SRSF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRSF8 Gene

ENSEMBL:
Gene Tree for SRSF8 (if available)
TreeFam:
Gene Tree for SRSF8 (if available)

Paralogs for SRSF8 Gene

Selected SIMAP similar genes for SRSF8 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SRSF8 Gene

genes like me logo Genes that share paralogs with SRSF8: view

No data available for Paralogs for SRSF8 Gene

Variants for SRSF8 Gene

Sequence variations from dbSNP and Humsavar for SRSF8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12627 -- 95,069,457(-) CTATT(G/T)TCACC utr-variant-3-prime, nc-transcript-variant
rs652744 -- 95,065,284(-) CATGC(G/T)CATAC upstream-variant-2KB
rs653573 -- 95,071,688(-) aatac(C/T)tttaa downstream-variant-500B
rs663629 -- 95,071,344(-) cccag(A/C)aaatg downstream-variant-500B
rs680673 -- 95,069,880(-) AAATA(A/T)ACCTC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SRSF8 Gene

Variant ID Type Subtype PubMed ID
nsv898188 CNV Loss 21882294

Relevant External Links for SRSF8 Gene

HapMap Linkage Disequilibrium report
SRSF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF8 Gene

Disorders for SRSF8 Gene

No disorders were found for SRSF8 Gene.

No data available for UniProtKB/Swiss-Prot for SRSF8 Gene

Publications for SRSF8 Gene

  1. Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. (PMID: 9671500) Soret J. … Perbal B. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for SRSF8 Gene

Sources for SRSF8 Gene

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