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SRSF8 Gene

protein-coding   GIFtS: 48
GCID: GC11P094801

Serine/Arginine-Rich Splicing Factor 8

(Previous names: splicing factor, arginine/serine-rich 2B)
(Previous symbol: SFRS2B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine-Rich Splicing Factor 81 2     Splicing Factor SRp462 3
SFRS2B1 2 3 5     SRP462 3
Splicing Factor, Arginine/Serine-Rich 2B1 2 3     DSM-12
SR Splicing Factor 81 2     Splicing Factor, Arginine/Serine-Rich, 46kD2
Pre-MRNA-Splicing Factor SRP462 3     SRp465

External Ids:    HGNC: 169881   Entrez Gene: 109292   Ensembl: ENSG000001807717   OMIM: 6032695   UniProtKB: Q9BRL63   

Export aliases for SRSF8 gene to outside databases

Previous GC identifer: GC11P090864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRSF8 Gene:
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and
a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing
factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for SRSF8 Gene:
SRSF8 (serine/arginine-rich splicing factor 8) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6
Function: Involved in pre-mRNA alternative splicing




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF8
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SRSF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

SRSF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF8 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P094801:  view genomic region     (about GC identifiers)

Start:
94,800,056 bp from pter      End:
94,804,388 bp from pter
Size:
4,333 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 8  
Size: 282 amino acids; 32288 Da
1 PDB 3D structure from and Proteopedia for SRSF8:
2DNM (3D)    
Secondary accessions: B2R6B8 Q6PF01 Q96TA3
Alternative splicing: 2 isoforms:  Q9BRL6-1   Q9BRL6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF8: NX_Q9BRL6

Explore proteomics data for SRSF8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys36
  • Modification sites at PhosphoSitePlus

  • See SRSF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115285.1  

    SRSF8 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9BRL6

    ProtoNet protein and cluster: Q9BRL6

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SRSF8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF8_HUMAN, Q9BRL6
    Function: Involved in pre-mRNA alternative splicing

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRSF8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SRSF8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF8
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    2 qRT-PCR Assays for microRNAs that regulate SRSF8:
    hsa-miR-576-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSRSF8 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRSF8_HUMAN, Q9BRL6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with SRSF8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRSF8 About    
    See pathways by source

    SuperPathContained pathways About
    1Influenza A
    Herpes simplex infection0.33
    2Spliceosome
    Spliceosome


    Find genes that share SuperPaths with SRSF8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for SRSF8):
        Spliceosome
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF8
    Interactions:

        Search GeneGlobe Interaction Network for SRSF8

    3 Interacting proteins for SRSF8 (Q9BRL61, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SREK1Q8WXA93I2D: score=1 
    SRPK1Q96SB41EBI-6380719,EBI-539478
    SRPK2P783621EBI-6380719,EBI-593303
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    Find genes that share ontologies with SRSF8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRSF8 gene: 
    NM_032102.3  

    Unigene Cluster for SRSF8:

    Serine/arginine-rich splicing factor 8
    Hs.476680  [show with all ESTs]
    Unigene Representative Sequence: NM_032102
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000446101(uc001pff.3)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SRSF8:
    hsa-miR-576-3p hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidSRSF8 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SRSF8
      QuantiFast Probe-based Assays in human, mouse, rat SRSF8

    Additional mRNA sequence: 

    AF031166.1 AK023379.1 AK309776.1 AK312514.1 BC057783.1 

    11 DOTS entries:

    DT.75164423  DT.109468  DT.95317939  DT.97777649  DT.101963522  DT.120728477  DT.92461020  DT.92461043 
    DT.92060821  DT.120728476  DT.120728479 

    Selected AceView cDNA sequences (see all 205):

    BE908225 AI052081 BI822097 BF445759 BQ269580 AW001874 BF514256 AI523729 
    BE504491 CA941600 AW293089 AI608751 AI985549 CA420471 AI201483 AW152113 
    BM311298 BQ186489 AI613013 CD108251 BU625474 BE672973 BQ220644 CR623195 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRSF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTGAGTT
    SRSF8 Expression
    About this image

    SRSF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476680

    UniProtKB/Swiss-Prot: SRSF8_HUMAN, Q9BRL6
    Tissue specificity: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and
    thymus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for SRSF8 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia SRSF81 serine/arginine-rich splicing factor 8 99.65(n)
    99.65(a)
      738544  XM_001139465.2  XP_001139465.2 


    ENSEMBL Gene Tree for SRSF8 (if available)
    TreeFam Gene Tree for SRSF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRSF8 gene
    7 SIMAP similar genes for SRSF8 using alignment to 1 protein entry:     SRSF8_HUMAN:
    SRSF2    LOC346472    LOC392896    SFRS2    SRSF10    SRSF12
    SFRS4

    Find genes that share paralogs with SRSF8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRSF8 (see all 51)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3759467811,2
    C--94800528(+) ATCCCA/GCGGGA 2 P syn10--------
    rs1440165941,2
    C--94800781(+) GGCGGA/CGACAC 2 R syn10--------
    rs1485099381,2
    C--94801365(+) TTTCTA/GCCTTT 1 -- ut310--------
    rs40194051,2
    C--94803531(-) ttttt-/T/TT  
            
    nngag
    2 -- ut311NA 2
    rs3740526661,2
    ----94800517(+) GCGACC/GTGTAC 2 L V mis10--------
    rs3716241411,2
    ----94800513(+) GTGGGC/TGACGT 2 G syn10--------
    rs32041681,2
    ----94804378(+) CTGTTA/CTATTG 1 -- ut310--------
    rs3746977191,2
    ----94803555(+) AAAAGA/GAAAAA 1 -- ut310--------
    rs3680194921,2
    ----94801276(+) GGACTC/TGGGGG 1 -- ut310--------
    rs3748588031,2
    ----94800829(+) GCAGCC/GGATCT 2 R G mis10--------

    HapMap Linkage Disequilibrium report for SRSF8 (94800056 - 94804388 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRSF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898188CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SRSF8
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603269    OMIM disorders: --


    Find genes that share disorders with SRSF8           About GenesLikeMe


    Export disorders for SRSF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRSF8 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with SRSF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of SRp46, a novel human SR splicing factor encoded by a PR264/SC35 retropseudogene. (PubMed id 9671500)1, 2, 3, 9 Soret J....Perbal B. (Mol. Cell. Biol. 1998)
    2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    7. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10929 HGNC: 16988 AceView: SRP46 Ensembl:ENSG00000180771 euGenes: HUgn10929
    ECgene: SRSF8 Kegg: 10929 H-InvDB: SRSF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRSF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRSF8 gene:
    Search GeneIP for patents involving SRSF8

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for SRSF8   OriGene RNAi products in human, mouse, rat for SRSF8  
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      eBioscience FlowRNA Probe Sets
           
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