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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF7 Gene

protein-coding   GIFtS: 56
GCID: GC02M038971

Serine/Arginine-Rich Splicing Factor 7

(Previous names: splicing factor, arginine/serine-rich 7 (35kD), splicing...)
(Previous symbol: SFRS7)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Arginine-Rich Splicing Factor 71 2     Splicing Factor, Arginine/Serine-Rich 7 (35kD)1
SFRS71 2 3 5     9G82
Splicing Factor, Arginine/Serine-Rich 7, 35kDa1 2     AAG32
SR Splicing Factor 71 2     Aging-Associated Protein 32
Splicing Factor 9G82 3     Splicing Factor, Arginine/Serine-Rich 73

External Ids:    HGNC: 107891   Entrez Gene: 64322   Ensembl: ENSG000001158757   OMIM: 6005725   UniProtKB: Q166293   

Export aliases for SRSF7 gene to outside databases

Previous GC identifer: GC02M038709


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF7 Gene:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,
which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for
binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues
and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA
splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2010)

GeneCards Summary for SRSF7 Gene: 
SRSF7 (serine/arginine-rich splicing factor 7) is a protein-coding gene. Diseases associated with SRSF7 include allergic bronchopulmonary aspergillosis, and hypobetalipoproteinemia, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629
Function: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing
of MAPT/Tau exon 10

Gene Wiki entry for SRSF7 (SFRS7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

SRSF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M038971:  view genomic region     (about GC identifiers)

Start:
38,970,741 bp from pter      End:
38,978,636 bp from pter
Size:
7,896 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 7  
Size: 238 amino acids; 27367 Da
Subunit: Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or
CDC2L2. Interacts with CCNL2 and CPSF6
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for SRSF7:
2HVZ (3D)    
Secondary accessions: B4DLU6 G5E9M3 Q564D3
Alternative splicing: 4 isoforms:  Q16629-1   Q16629-2   Q16629-3   Q16629-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF7: NX_Q16629

Explore proteomics data for SRSF7 at MOPED 

Post-translational modifications:

  • UniProtKB: Extensively phosphorylated on serine residues in the RS domain
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16629

  • SRSF7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRSF7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001026854.1  NP_001182375.1  

    ENSEMBL proteins: 
     ENSP00000325905   ENSP00000400246   ENSP00000416516   ENSP00000392300   ENSP00000401202  
     ENSP00000386806   ENSP00000398159   ENSP00000402544   ENSP00000408868   ENSP00000402264  
    Reactome Protein details: Q16629
    Human Recombinant Protein Products for SRSF7: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRSF7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    SRSF7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZCCHC: Zinc fingers, CCHC domain containing
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    3 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q16629

    ProtoNet protein and cluster: Q16629

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 CCHC-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SRSF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF7_HUMAN, Q16629
    Function: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing
    of MAPT/Tau exon 10

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI14559993
    GO:0008270zinc ion binding IEA--
         
    SRSF7 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Srsf7):
     mortality/aging 

    SRSF7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRSF7 
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    SwitchGear 3'UTR luciferase reporter plasmidSRSF7 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRSF7 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    mRNA Splicing0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF7
        mRNA processing

    5/15        Reactome Pathways for SRSF7 (see all 15)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    2         Kegg Pathways  (Kegg details for SRSF7):
        Spliceosome
    Herpes simplex infection


    SRSF7 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/890 Interacting proteins for SRSF7 (Q166291, 2, 3 ENSP000003259054) via UniProtKB, MINT, STRING, and/or I2D (see all 890)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU92, 3, ENSP000002941724MINT-3380010 MINT-3380040 MINT-3380069 I2D: score=4 STRING: ENSP00000294172
    HNRNPKP619782, 3, ENSP000003654394MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000365439
    RBM39Q144982, 3, ENSP000002533634MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000253363
    SF3A2Q154282, 3, ENSP000002214944MINT-5205710 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS8013463
    GO:0006406mRNA export from nucleus TAS--

    SRSF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRSF7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF7

    3 Novoseek inferred chemical compound relationships for SRSF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 53.4 7 8013463 (2), 10022858 (1), 17036044 (1), 20016065 (1) (see all 6)
    arginine 38.6 4 8013463 (2), 10022858 (1), 17135210 (1)
    zinc 21.6 11 10094314 (4), 9761791 (2), 8013463 (1)

    Search CenterWatch for drugs/clinical trials and news about SRSF7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRSF7 gene (3 alternative transcripts): 
    NM_001031684.2  NM_001195446.1  NM_006276.36  

    Unigene Cluster for SRSF7:

    Serine/arginine-rich splicing factor 7
    Hs.309090  [show with all ESTs]
    Unigene Representative Sequence: AK091425
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313117(uc002rqz.3 uc010ynp.2) ENST00000425778(uc002rra.3)
    ENST00000425941 ENST00000452806 ENST00000432873 ENST00000409276 ENST00000477635
    ENST00000431066 ENST00000443213 ENST00000487773 ENST00000415527 ENST00000446327


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    Additional mRNA sequence: 

    AB445102.1 AK091425.1 AK225141.1 AK293667.1 AK297161.1 AY166860.1 AY513287.1 BC000997.2 
    BC017369.2 BC017908.1 BC022328.1 BT006745.1 L22253.1 

    24/30 DOTS entries (see all 30):

    DT.100665423  DT.100665415  DT.100665414  DT.100665412  DT.448709  DT.92454680  DT.95372973  DT.100665422 
    DT.95372974  DT.95372971  DT.120947170  DT.92454691  DT.95372977  DT.95372978  DT.100038528  DT.100832829 
    DT.119441  DT.120947181  DT.95372983  DT.120947165  DT.100661989  DT.100665416  DT.100665418  DT.100665424 

    24/573 AceView cDNA sequences (see all 573):

    BU161635 CA430673 AI436178 BP378046 BE503285 AI559759 BQ889753 BM665923 
    BX456862 BX460369 BM817651 AI246709 BG150249 BP347674 CR598097 AA284625 
    BC000997 CA413115 BX952564 BX504817 BQ084417 CB529764 BE326601 AA425156 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF7 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ·
    SP1:                          -     -                             -                       -     -     -                                                         
    SP2:                          -     -                             -     -     -     -     -     -     -                                                         
    SP3:                          -     -                             -     -     -     -     -     -     -                                         -               
    SP4:                          -     -                             -     -     -     -     -     -     -                 -                                       
    SP5:                          -     -                             -     -     -     -     -     -     -                             -                           

    ExUns: 11c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SRSF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF7 expression in normal human tissues (normalized intensities)      SRSF7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCGGAGAT
    SRSF7 Expression
    About this image


    SRSF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Epithelium (Uncategorized)    fully expand to see all 3 entries
             vagina ; squamous epithelial cells   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Ventral Horn   
     
     Lower Urinary Tract (Urinary System)
             urinary bladder ; urothelial cells   

    See SRSF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF7

    SOURCE GeneReport for Unigene cluster: Hs.309090

    UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629
    Tissue specificity: Brain, liver, kidney and lung

        SABiosciences Expression via Pathway-Focused PCR Array including SRSF7: 
              Parkinson's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRSF7 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf71 , 5 serine/arginine-rich splicing factor 71, 5 92.06(n)1
    98.3(a)1
      17 (50.63 cM)5
    2250271  NM_001195485.11  NP_001182414.11 
     802000895 
    chicken
    (Gallus gallus)
    Aves LOC1008596091 uncharacterized LOC100859609 75.32(n)
    93.62(a)
      100859609  XM_003640934.1  XP_003640982.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF76
    Uncharacterized protein
    94(a)
    1 ↔ 1
    1(254028823-254037996)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.248062 Xenopus laevis transcribed sequence with moderate similarity more 83.27(n)    CA987868.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb39b022 Transcribed sequence with weak similarity to protein more 74.39(n)    CD759186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta x161 CG10203-PA 44.8(n)
    50.23(a)
      33967  NM_164718.1  NP_723226.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-61 Protein RSP-6 48.08(n)
    57.47(a)
      177566  NM_171383.2  NP_741446.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G245901 RNA recognition motif and CCHC-type zinc finger domain-containing more 50.69(n)
    49.11(a)
      816995  NM_128020.4  NP_180035.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g06106001 hypothetical protein 47.24(n)
    53.48(a)
      4329951  NM_001053935.1  NP_001047400.1 


    ENSEMBL Gene Tree for SRSF7 (if available)
    TreeFam Gene Tree for SRSF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF7 gene
    SRSF52  SRSF92  SRSF12  SRSF62  SRSF42  SRSF32  
    10 SIMAP similar genes for SRSF7 using alignment to 5 protein entries:     SRSF7_HUMAN (see all proteins):
    SFRS3    SRSF3    SFRS6    RALY    SFRS5    SRSF9
    SRSF12    SRSF5    SRSF2    ZCRB1

    SRSF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/332 SNPs in SRSF7 are shown (see all 332)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166282521,2
    F--38970317(+) GGCGCG/AAGCCA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1124775731,2
    C,F--38970324(+) GCCACC/TGCACC 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1814773781,2
    --38970408(+) ATGAGC/TCTGGA 2 -- ds50010--------
    rs1405125461,2
    C--38970418(+) AGCAGC/TACTTC 2 -- ds50010--------
    rs1504250261,2
    --38970470(+) CAAGTC/GGGGGG 2 -- ds50010--------
    rs800929951,2
    F--38970539(+) ACCTAA/CGAGGT 2 -- ds50010--------
    rs729091391,2
    C,F--38970549(+) TATTGG/ACCCAA 2 -- ds50012Minor allele frequency- A:0.20WA 120
    rs1438304991,2
    --38970654(+) AGGACA/GCTACT 2 -- ds50010--------
    rs1855640731,2
    --38970693(+) ATGCCC/TCCTAC 2 -- ds50010--------
    rs1472332841,2
    C--38970777(+) GAGTAA/GACTTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SRSF7 (38970741 - 38978636 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SRSF7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv820974CNV Duplication20802225
    esv2421335CNV Duplication20811451
    nsv9646CNV Loss18304495
    esv24300CNV Loss19812545
    nsv828997CNV Loss20364138
    nsv819664CNV Loss19587683
    nsv441752CNV CNV18776908

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600572    OMIM disorders: --

    12 diseases for SRSF7:    About MalaCards
    allergic bronchopulmonary aspergillosis    hypobetalipoproteinemia    aspergillosis    frontotemporal dementia
    hiv type 1    dementia    bipolar disorder    herpes simplex
    parkinson's disease    schizophrenia    hepatocellular carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SRSF7:
    Hypobetalipoproteinemia

    SRSF7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SRSF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 15 5 15458974 (1), 9523846 (1), 17623484 (1)


    Export disorders for SRSF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF7 gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with SRSF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. (PubMed id 8013463)1, 2, 3, 9 Cavaloc Y.... Stevenin J. (1994)
    2. The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts. (PubMed id 7629084)1, 2, 9 Popielarz M.... Stevenin J. (1995)
    3. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. (PubMed id 14684736)1, 2, 9 Yang L.... Cao X. (2004)
    4. Novel cis-active structures in the coding region medi ate CRM1-dependent nuclear export of IFN-I+ 1 mRNA. (PubMed id 20857263)1, 2 Kimura T....Yamada H. (2010)
    5. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (2004)
    9. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)1, 2 Wang J....Andreadis A. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6432 HGNC: 10789 AceView: SFRS7 Ensembl:ENSG00000115875 euGenes: HUgn6432
    ECgene: SRSF7 Kegg: 6432 H-InvDB: SRSF7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRSF7 gene:
    Search GeneIP for patents involving SRSF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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