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Aliases for SRSF7 Gene

Aliases for SRSF7 Gene

  • Serine/Arginine-Rich Splicing Factor 7 2 3
  • SFRS7 3 4 6
  • Splicing Factor, Arginine/Serine-Rich 7, 35kDa 2 3
  • SR Splicing Factor 7 2 3
  • Splicing Factor 9G8 3 4
  • Splicing Factor, Arginine/Serine-Rich 7 (35kD) 2
  • Splicing Factor, Arginine/Serine-Rich 7 4
  • Aging-Associated Protein 3 3
  • AAG3 3
  • 9G8 3

External Ids for SRSF7 Gene

Previous HGNC Symbols for SRSF7 Gene

  • SFRS7

Previous GeneCards Identifiers for SRSF7 Gene

  • GC02M038971

Summaries for SRSF7 Gene

Entrez Gene Summary for SRSF7 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF7 Gene

SRSF7 (Serine/Arginine-Rich Splicing Factor 7) is a Protein Coding gene. Diseases associated with SRSF7 include allergic bronchopulmonary aspergillosis. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF4.

UniProtKB/Swiss-Prot for SRSF7 Gene

  • Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

Gene Wiki entry for SRSF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF7 Gene

Genomics for SRSF7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRSF7 Gene

Start:
38,743,599 bp from pter
End:
38,751,494 bp from pter
Size:
7,896 bases
Orientation:
Minus strand

Genomic View for SRSF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF7 Gene

No data available for Regulatory Elements for SRSF7 Gene

Proteins for SRSF7 Gene

  • Protein details for SRSF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16629-SRSF7_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 7
    Protein Accession:
    Q16629
    Secondary Accessions:
    • B4DLU6
    • G5E9M3
    • Q564D3

    Protein attributes for SRSF7 Gene

    Size:
    238 amino acids
    Molecular mass:
    27367 Da
    Quaternary structure:
    • Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1.

    Three dimensional structures from OCA and Proteopedia for SRSF7 Gene

    Alternative splice isoforms for SRSF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF7 Gene

Proteomics data for SRSF7 Gene at MOPED

Post-translational modifications for SRSF7 Gene

  • Extensively phosphorylated on serine residues in the RS domain
  • Ubiquitination at Lys12 and Lys24
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRSF7 Gene

Domains for SRSF7 Gene

Gene Families for SRSF7 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors
  • ZCCHC :Zinc fingers, CCHC domain containing

Suggested Antigen Peptide Sequences for SRSF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16629

UniProtKB/Swiss-Prot:

SRSF7_HUMAN :
  • Q16629
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with SRSF7: view

Function for SRSF7 Gene

Molecular function for SRSF7 Gene

UniProtKB/Swiss-Prot Function: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

Gene Ontology (GO) - Molecular Function for SRSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 14559993
GO:0008270 zinc ion binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF7: view

Phenotypes for SRSF7 Gene

MGI mutant phenotypes for SRSF7:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SRSF7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRSF7 Gene

Localization for SRSF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF7 Gene COMPARTMENTS Subcellular localization image for SRSF7 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8013463
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with SRSF7: view

Pathways for SRSF7 Gene

genes like me logo Genes that share pathways with SRSF7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SRSF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing TAS 8013463
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF7: view

Compounds for SRSF7 Gene

(3) Novoseek inferred chemical compound relationships for SRSF7 Gene

Compound -log(P) Hits PubMed IDs
serine 53.4 7
arginine 38.6 4
zinc 21.6 7
genes like me logo Genes that share compounds with SRSF7: view

Transcripts for SRSF7 Gene

Unigene Clusters for SRSF7 Gene

Serine/arginine-rich splicing factor 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SRSF7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF7 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11:
SP12: -
SP13: -
SP14: - -
SP15:

ExUns: 11c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for SRSF7 Gene

GeneLoc Exon Structure for
SRSF7
ECgene alternative splicing isoforms for
SRSF7

Expression for SRSF7 Gene

mRNA expression in normal human tissues for SRSF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF7 Gene

SOURCE GeneReport for Unigene cluster for SRSF7 Gene Hs.309090

mRNA Expression by UniProt/SwissProt for SRSF7 Gene

Q16629-SRSF7_HUMAN
Tissue specificity: Brain, liver, kidney and lung
genes like me logo Genes that share expressions with SRSF7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SRSF7 Gene

Orthologs for SRSF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF7 35
  • 99.86 (n)
  • 100 (a)
SRSF7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRSF7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF7 35
  • 94.12 (n)
  • 98.32 (a)
SRSF7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf7 35
  • 92.3 (n)
  • 98.32 (a)
Srsf7 16
Srsf7 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF7 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf7 35
  • 92.3 (n)
  • 98.32 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 88 (a)
OneToMany
LOC100859609 35
  • 75.07 (n)
  • 93.28 (a)
SRSF7 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SRSF7 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24806 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8131 35
zebrafish
(Danio rerio)
Actinopterygii srsf7a 36
  • 62 (a)
OneToOne
wufb39b02 35
fruit fly
(Drosophila melanogaster)
Insecta Rbp1 36
  • 50 (a)
OneToMany
Rbp1-like 36
  • 32 (a)
OneToMany
x16 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y57G11A.5 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2245 36
  • 57 (a)
OneToMany
CSA.3629 36
  • 52 (a)
OneToMany
Species with no ortholog for SRSF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF7 Gene

ENSEMBL:
Gene Tree for SRSF7 (if available)
TreeFam:
Gene Tree for SRSF7 (if available)

Paralogs for SRSF7 Gene

Paralogs for SRSF7 Gene

Selected SIMAP similar genes for SRSF7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SRSF7: view

Variants for SRSF7 Gene

Sequence variations from dbSNP and Humsavar for SRSF7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2236755 -- 38,748,397(-) TTCTC(C/T)TACCT intron-variant
rs3108661 -- 38,751,708(+) CATTA(A/G)ACCGG upstream-variant-2KB
rs3108668 -- 38,744,908(+) AACAT(G/T)TTATT utr-variant-3-prime
rs3108669 -- 38,746,672(-) AAAAG(C/G)ATAAT intron-variant
rs3108670 -- 38,747,232(+) ATTCC(C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF7 Gene

Variant ID Type Subtype PubMed ID
nsv9646 CNV Loss 18304495
nsv820974 CNV Duplication 20802225
nsv819664 CNV Loss 19587683
nsv828997 CNV Loss 20364138
nsv441752 CNV CNV 18776908
esv2421335 CNV Duplication 20811451
esv24300 CNV Loss 19812545

Relevant External Links for SRSF7 Gene

HapMap Linkage Disequilibrium report
SRSF7
Human Gene Mutation Database (HGMD)
SRSF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF7 Gene

Disorders for SRSF7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SRSF7 Gene including...

Search for SRSF7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SRSF7 Gene

(1) Novoseek inferred disease relationships for SRSF7 Gene

Disease -log(P) Hits PubMed IDs
shock 15 3
genes like me logo Genes that share disorders with SRSF7: view

No data available for UniProtKB/Swiss-Prot for SRSF7 Gene

Publications for SRSF7 Gene

  1. Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. (PMID: 8013463) Cavaloc Y. … Stevenin J. (EMBO J. 1994) 2 3 4 23
  2. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. (PMID: 14684736) Yang L. … Cao X. (J. Biol. Chem. 2004) 3 4 23
  3. The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts. (PMID: 7629084) Popielarz M. … Stevenin J. (J. Biol. Chem. 1995) 3 4 23
  4. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PMID: 17036044) Hargous Y. … Allain F.H. (EMBO J. 2006) 3 4 23
  5. CDK11 complexes promote pre-mRNA splicing. (PMID: 12501247) Hu D. … Kidd V.J. (J. Biol. Chem. 2003) 3 4

Products for SRSF7 Gene

Sources for SRSF7 Gene

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