Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SRSF7 Gene

protein-coding   GIFtS: 56
GCID: GC02M038971

Serine/Arginine-Rich Splicing Factor 7

(Previous names: splicing factor, arginine/serine-rich 7 (35kD), splicing...)
(Previous symbol: SFRS7)
  See SRSF7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Serine/Arginine-Rich Splicing Factor 71 2     Splicing Factor, Arginine/Serine-Rich 7 (35kD)1
SFRS71 2 3 5     9G82
Splicing Factor, Arginine/Serine-Rich 7, 35kDa1 2     AAG32
SR Splicing Factor 71 2     Aging-Associated Protein 32
Splicing Factor 9G82 3     Splicing Factor, Arginine/Serine-Rich 73

External Ids:    HGNC: 107891   Entrez Gene: 64322   Ensembl: ENSG000001158757   OMIM: 6005725   UniProtKB: Q166293   

Export aliases for SRSF7 gene to outside databases

Previous GC identifer: GC02M038709


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SRSF7 Gene:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,
which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for
binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues
and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA
splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Sep 2010)

GeneCards Summary for SRSF7 Gene:
SRSF7 (serine/arginine-rich splicing factor 7) is a protein-coding gene. Diseases associated with SRSF7 include allergic bronchopulmonary aspergillosis. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629
Function: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing
of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds
mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances
NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific

Gene Wiki entry for SRSF7 (SFRS7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF7 promoter sequence
   Search Chromatin IP Primers for SRSF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

SRSF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M038971:  view genomic region     (about GC identifiers)

Start:
38,970,741 bp from pter      End:
38,978,636 bp from pter
Size:
7,896 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 7  
Size: 238 amino acids; 27367 Da
Subunit: Found in large molecular weight complexes containing CCNL1 and the p110 isoforms of either CDC2L1 or
CDC2L2. Interacts with CCNL2 and CPSF6. Interacts with NXF1
1 PDB 3D structure from and Proteopedia for SRSF7:
2HVZ (3D)    
Secondary accessions: B4DLU6 G5E9M3 Q564D3
Alternative splicing: 4 isoforms:  Q16629-1   Q16629-2   Q16629-3   Q16629-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF7: NX_Q16629

Explore proteomics data for SRSF7 at MOPED

Post-translational modifications: 

  • Extensively phosphorylated on serine residues in the RS domain1
  • Ubiquitination2 at Lys12, Lys24
  • Modification sites at PhosphoSitePlus

  • See SRSF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026854.1  NP_001182375.1  

    ENSEMBL proteins: 
     ENSP00000325905   ENSP00000400246   ENSP00000416516   ENSP00000392300   ENSP00000401202  
     ENSP00000386806   ENSP00000398159   ENSP00000402544   ENSP00000408868   ENSP00000402264  
    Reactome Protein details: Q16629

    SRSF7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SRSF7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SRSF7
    GenScript Custom Purified and Recombinant Proteins Services for SRSF7
    Novus Biologicals SRSF7 Protein
    Novus Biologicals SRSF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRSF7

     
    Search eBioscience for Proteins for SRSF7 

    SRSF7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SRSF7
    OriGene Custom Antibody Services for SRSF7
    Novus Biologicals SRSF7 Antibodies
    Search for Antibodies for SRSF7 at Abcam
    Cloud-Clone Corp. Antibodies for SRSF7
    Search ThermoFisher Antibodies for SRSF7
    LSBio Antibodies in human, mouse, rat for SRSF7

    SRSF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRSF7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRSF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRSF7
    Cloud-Clone Corp. CLIAs for SRSF7
    Search eBioscience for ELISAs for SRSF7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZCCHC: Zinc fingers, CCHC domain containing
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    3 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry Q16629

    ProtoNet protein and cluster: Q16629

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001878 C2HC-type zinc-finger signature


    UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 CCHC-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SRSF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF7_HUMAN, Q16629
    Function: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing
    of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds
    mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances
    NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI14559993
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with SRSF7           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Srsf7):
     mortality/aging 

    Find genes that share phenotypes with SRSF7           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRSF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRSF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRSF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRSF7:
    hsa-mir-421 (MIRT016101), hsa-mir-19b-3p (MIRT031228), hsa-mir-130b-3p (MIRT020279), hsa-mir-1 (MIRT023916), hsa-mir-374b-5p (MIRT016062), hsa-mir-22-3p (MIRT030646), hsa-mir-181a-5p (MIRT025199)

    Block miRNA regulation of human, mouse, rat SRSF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF7 (see all 65):
    hsa-miR-188-5p hsa-miR-4272 hsa-miR-605 hsa-miR-374a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidSRSF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRSF7
    Predesigned siRNA for gene silencing in human, mouse, rat SRSF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRSF7

    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF7 (see all 12)
    OriGene ORF clones in mouse, rat for SRSF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF7 (NM_001031684)
    Sino Biological Human cDNA Clone for SRSF7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRSF7
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRSF7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SRSF7_HUMAN, Q16629: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SRSF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SRSF7 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SRSF7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF7
        mRNA processing


    5 Reactome Pathways for SRSF7
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region
    mRNA Splicing - Minor Pathway


    2 Kegg Pathways  (Kegg details for SRSF7):
        Spliceosome
    Herpes simplex infection

        Pathway & Disease-focused RT2 Profiler PCR Array including SRSF7: 
              Parkinson's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SRSF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRSF7 (Q166291, 2, 3 ENSP000003259054) via UniProtKB, MINT, STRING, and/or I2D (see all 906)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU91, 2, 3, ENSP000002941724EBI-398885,EBI-398874 MINT-3380010 MINT-3380040 MINT-3380069 I2D: score=4 STRING: ENSP00000294172
    HNRNPKP619782, 3, ENSP000003654394MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000365439
    RBM39Q144982, 3, ENSP000002533634MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000253363
    SF3A2Q154282, 3, ENSP000002214944MINT-5205710 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS8013463
    GO:0006406mRNA export from nucleus TAS--

    Find genes that share ontologies with SRSF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF7

    3 Novoseek inferred chemical compound relationships for SRSF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 53.4 7 8013463 (2), 10022858 (1), 17036044 (1), 20016065 (1) (see all 6)
    arginine 38.6 4 8013463 (2), 10022858 (1), 17135210 (1)
    zinc 21.6 11 10094314 (4), 9761791 (2), 8013463 (1)



    Find genes that share compounds with SRSF7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SRSF7 gene (3 alternative transcripts): 
    NM_001031684.2  NM_001195446.1  NM_006276.36  

    Unigene Cluster for SRSF7:

    Serine/arginine-rich splicing factor 7
    Hs.309090  [show with all ESTs]
    Unigene Representative Sequence: AK091425
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313117(uc002rqz.3 uc010ynp.2) ENST00000425778(uc002rra.3)
    ENST00000425941 ENST00000452806 ENST00000432873 ENST00000409276 ENST00000477635
    ENST00000431066 ENST00000443213 ENST00000487773 ENST00000415527 ENST00000446327

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRSF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF7 (see all 65):
    hsa-miR-188-5p hsa-miR-4272 hsa-miR-605 hsa-miR-374a hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-489
    SwitchGear 3'UTR luciferase reporter plasmidSRSF7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRSF7
    Predesigned siRNA for gene silencing in human, mouse, rat SRSF7
    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF7 (see all 12)
    OriGene ORF clones in mouse, rat for SRSF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF7 (NM_001031684)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF7
      QuantiTect SYBR Green Assays in human, mouse, rat SRSF7
      Search QuantiFast Probe-based Assays in human, mouse, rat SRSF7

    Additional mRNA sequence: 

    AB445102.1 AK091425.1 AK225141.1 AK293667.1 AK297161.1 AY166860.1 AY513287.1 BC000997.2 
    BC017369.2 BC017908.1 BC022328.1 BT006745.1 L22253.1 

    Selected DOTS entries (see all 30):

    DT.100665423  DT.100665415  DT.100665414  DT.100665412  DT.448709  DT.92454680  DT.95372973  DT.100665422 
    DT.95372974  DT.95372971  DT.120947170  DT.92454691  DT.95372977  DT.95372978  DT.100038528  DT.100832829 
    DT.119441  DT.120947181  DT.95372983  DT.120947165  DT.100661989  DT.100665416  DT.100665418  DT.100665424 

    Selected AceView cDNA sequences (see all 573):

    AW193010 BM829487 BP369356 AL557453 BQ218596 CR598891 BM452957 BM997151 
    AI657129 BC017369 AI926911 BM785067 BQ549855 BF438716 CB529530 BU184592 
    BU737276 AI422435 BU184097 BM817651 N50345 BP374996 BQ424677 AA418813 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRSF7 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ·
    SP1:                          -     -                             -                       -     -     -                                                         
    SP2:                          -     -                             -     -     -     -     -     -     -                                                         
    SP3:                          -     -                             -     -     -     -     -     -     -                                         -               
    SP4:                          -     -                             -     -     -     -     -     -     -                 -                                       
    SP5:                          -     -                             -     -     -     -     -     -     -                             -                           

    ExUns: 11c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SRSF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SRSF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCGGAGAT
    SRSF7 Expression
    About this image


    SRSF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Bone Marrow
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Ovary (Reproductive System)
             Oviduct
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    SRSF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.309090

    UniProtKB/Swiss-Prot: SRSF7_HUMAN, Q16629
    Tissue specificity: Brain, liver, kidney and lung

        Pathway & Disease-focused RT2 Profiler PCR Array including SRSF7: 
              Parkinson's Disease in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF7
    QuantiTect SYBR Green Assays in human, mouse, rat SRSF7
    Search QuantiFast Probe-based Assays in human, mouse, rat SRSF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SRSF7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf71 , 5 serine/arginine-rich splicing factor 71, 5 92.3(n)1
    98.32(a)1
      17 (50.63 cM)5
    2250271  NM_146083.21  NP_666195.11 
     802000895 
    chicken
    (Gallus gallus)
    Aves LOC1008596091 serine/arginine-rich splicing factor 7-like 75.07(n)
    93.28(a)
      100859609  XM_004935270.1  XP_004935327.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF76
    serine/arginine-rich splicing factor 7
    94(a)
    1 ↔ 1
    1(254028823-254037996)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.248062 Xenopus laevis transcribed sequence with moderate similarity more 83.27(n)    CA987868.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb39b022 Transcribed sequence with weak similarity to protein more 74.39(n)    CD759186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rbp16
    x166
    (see all 3)
    --
    50(a)
    45(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    3R(6610104-6612187)
    2L(6914300-6920210)
    worm
    (Caenorhabditis elegans)
    Secernentea Y57G11A.56
    Protein Y57G11A.5 (Y57G11A.5) mRNA, complete cds
    38(a)
    1 ↔ 1
    IV(14511884-14512505) WBGene00013293


    ENSEMBL Gene Tree for SRSF7 (if available)
    TreeFam Gene Tree for SRSF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SRSF7 gene
    SRSF52  SRSF92  SRSF12  SRSF62  SRSF42  SRSF32  
    10 SIMAP similar genes for SRSF7 using alignment to 5 protein entries:     SRSF7_HUMAN (see all proteins):
    SFRS3    SRSF3    SFRS6    RALY    SFRS5    SRSF9
    SRSF12    SRSF5    SRSF2    ZCRB1

    Find genes that share paralogs with SRSF7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SRSF7 (see all 332)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1166282521,2
    F--38970317(+) GGCGCG/AAGCCA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1124775731,2
    C,F--38970324(+) GCCACC/TGCACC 2 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1814773781,2
    --38970408(+) ATGAGC/TCTGGA 2 -- ds50010--------
    rs1405125461,2
    C--38970418(+) AGCAGC/TACTTC 2 -- ds50010--------
    rs1504250261,2
    --38970470(+) CAAGTC/GGGGGG 2 -- ds50010--------
    rs800929951,2
    F--38970539(+) ACCTAA/CGAGGT 2 -- ds50010--------
    rs729091391,2
    C,F--38970549(+) TATTGG/ACCCAA 2 -- ds50012Minor allele frequency- A:0.20WA 120
    rs1438304991,2
    --38970654(+) AGGACA/GCTACT 2 -- ds50010--------
    rs1855640731,2
    --38970693(+) ATGCCC/TCCTAC 2 -- ds50010--------
    rs1472332841,2
    C--38970777(+) GAGTAA/GACTTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SRSF7 (38970741 - 38978636 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SRSF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820974CNV Duplication20802225
    esv2421335CNV Duplication20811451
    nsv9646CNV Loss18304495
    esv24300CNV Loss19812545
    nsv828997CNV Loss20364138
    nsv819664CNV Loss19587683
    nsv441752CNV CNV18776908

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF7
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600572    OMIM disorders: --

    1 disease for SRSF7:    
    About MalaCards
    allergic bronchopulmonary aspergillosis

    1 disease from the University of Copenhagen DISEASES database for SRSF7:
    Hypobetalipoproteinemia

    Find genes that share disorders with SRSF7           About GenesLikeMe

    1 Novoseek inferred disease relationship for SRSF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 15 5 15458974 (1), 9523846 (1), 17623484 (1)


    Export disorders for SRSF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SRSF7 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with SRSF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. (PubMed id 8013463)1, 2, 3, 9 Cavaloc Y.... Stevenin J. (EMBO J. 1994)
    2. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PubMed id 17036044)1, 2, 9 Hargous Y....Allain F.H. (EMBO J. 2006)
    3. The gene encoding human splicing factor 9G8. Structure, chromosomal localization, and expression of alternatively processed transcripts. (PubMed id 7629084)1, 2, 9 Popielarz M.... Stevenin J. (J. Biol. Chem. 1995)
    4. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. (PubMed id 14684736)1, 2, 9 Yang L.... Cao X. (J. Biol. Chem. 2004)
    5. Novel cis-active structures in the coding region mediate CRM1- dependent nuclear export of IFN-alpha 1 mRNA. (PubMed id 20857263)1, 2 Kimura T.... Yamada H. (Med. Mol. Morphol. 2010)
    6. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)1, 2 Choudhary C.... Mann M. (Science 2009)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6432 HGNC: 10789 AceView: SFRS7 Ensembl:ENSG00000115875 euGenes: HUgn6432
    ECgene: SRSF7 Kegg: 6432 H-InvDB: SRSF7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SRSF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SRSF7 gene:
    Search GeneIP for patents involving SRSF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SRSF7   OriGene RNAi products in human, mouse, rat for SRSF7  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SRSF7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SRSF7  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRSF7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SRSF7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRSF7   OriGene Custom Protein Services for SRSF7  

     
     
     Block miRNA regulation of human, mouse, rat SRSF7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SRSF7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF7 Predesigned siRNA for gene silencing in human, mouse, rat SRSF7
     Search QuantiFast Probe-based Assays in human, mouse, rat SRSF7 QuantiTect SYBR Green Assays in human, mouse, rat SRSF7
     PCR Arrays including human, mouse, rat SRSF7 Search Chromatin IP Primers for SRSF7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF7  Search GeneGlobe Interaction Network for SRSF7
     Search Regulatory tfbs for SRSF7
     GenScript Custom Purified and Recombinant Proteins Services for SRSF7 GenScript cDNA clones with any tag delivered in your preferred vector for SRSF7
     GenScript Custom Assay Services for SRSF7 GenScript Custom overexpressing Cell Line Services for SRSF7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SRSF7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SRSF7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SRSF7 antibodies
     SRSF7 proteins
     SRSF7 lysates
     Search for Antibodies for SRSF7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SRSF7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SRSF7
     Antibodies for SRSF7
     ELISAs for SRSF7
     CLIAs for SRSF7



     Browse ESI BIO Cell Lines and PureStem Progenitors for SRSF7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF7
     SwitchGear 3'UTR luciferase reporter plasmids for SRSF7
     SwitchGear Promoter luciferase reporter plasmids for SRSF7
     Search ThermoFisher Antibodies for SRSF7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRSF7
     LSBio Antibodies in human, mouse, rat for SRSF7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SRSF7
      Search eBioscience for proteins for SRSF7
      Search eBioscience for elisas for SRSF7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRSF7 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4