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Aliases for SRSF6 Gene

Aliases for SRSF6 Gene

  • Serine And Arginine Rich Splicing Factor 6 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 6 2 4
  • Serine/Arginine-Rich Splicing Factor 6 2 3
  • Pre-MRNA-Splicing Factor SRP55 3 4
  • SR Splicing Factor 6 2 3
  • SFRS6 3 4
  • SRP55 3 4
  • Splicing Factor, Arginine/Serine-Rich, 55 KDa 3
  • Epididymis Secretory Protein Li 91 3
  • Pre-MRNA Splicing Factor SRP55 2
  • HEL-S-91 3
  • B52 3

External Ids for SRSF6 Gene

Previous HGNC Symbols for SRSF6 Gene

  • SFRS6

Previous GeneCards Identifiers for SRSF6 Gene

  • GC20P042087
  • GC20P038822

Summaries for SRSF6 Gene

Entrez Gene Summary for SRSF6 Gene

  • The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF6 Gene

SRSF6 (Serine And Arginine Rich Splicing Factor 6) is a Protein Coding gene. Diseases associated with SRSF6 include Herpes Gestationis and Behcet Syndrome. Among its related pathways are Transport of Mature Transcript to Cytoplasm and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF4.

UniProtKB/Swiss-Prot for SRSF6 Gene

  • Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

Gene Wiki entry for SRSF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF6 Gene

Genomics for SRSF6 Gene

Regulatory Elements for SRSF6 Gene

Enhancers for SRSF6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F043656 1.3 FANTOM5 Ensembl ENCODE 4.6 +199.8 199816 2.8 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK IFT52 MYBL2 SGK2 OSER1 SRSF6 L3MBTL1 GC20P043655
GH20F043456 1.4 ENCODE 0.8 +0.4 353 3.4 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000237555 LOC101927138 LINC01728 RPL27AP IFT52 SRSF6 GC20P043474
GH20F043457 0.2 ENCODE 0.8 -1.5 -1479 0.2 DRAP1 ZNF316 NFYB NFYC KLF9 ZBTB33 SRSF6 GC20M043452 ENSG00000206998
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SRSF6 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000401291 36 2601 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SRSF6 Gene

Chromosome:
20
Start:
43,457,864 bp from pter
End:
43,464,247 bp from pter
Size:
6,384 bases
Orientation:
Plus strand

Genomic View for SRSF6 Gene

Genes around SRSF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF6 Gene

Proteins for SRSF6 Gene

  • Protein details for SRSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13247-SRSF6_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 6
    Protein Accession:
    Q13247
    Secondary Accessions:
    • B7Z6J3
    • E1P5W6
    • Q13244
    • Q13245
    • Q96J06
    • Q9UJB8
    • Q9Y3N7

    Protein attributes for SRSF6 Gene

    Size:
    344 amino acids
    Molecular mass:
    39587 Da
    Quaternary structure:
    • Binds SREK1/SFRS12. Interacts with DYRK1A.

    Alternative splice isoforms for SRSF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF6 Gene

Post-translational modifications for SRSF6 Gene

  • Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
  • Ubiquitination at Lys 127, Lys 143, and Lys 165
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SRSF6 Gene

Domains & Families for SRSF6 Gene

Protein Domains for SRSF6 Gene

Suggested Antigen Peptide Sequences for SRSF6 Gene

Graphical View of Domain Structure for InterPro Entry

Q13247

UniProtKB/Swiss-Prot:

SRSF6_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF6: view

Function for SRSF6 Gene

Molecular function for SRSF6 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

Gene Ontology (GO) - Molecular Function for SRSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 24440982
GO:0005515 protein binding IPI 25416956
GO:0036002 pre-mRNA binding IDA 12549914
genes like me logo Genes that share ontologies with SRSF6: view
genes like me logo Genes that share phenotypes with SRSF6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF6 Gene

Localization for SRSF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF6 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF6 Gene COMPARTMENTS Subcellular localization image for SRSF6 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SRSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IEA,IDA 22767602
genes like me logo Genes that share ontologies with SRSF6: view

Pathways & Interactions for SRSF6 Gene

genes like me logo Genes that share pathways with SRSF6: view

Pathways by source for SRSF6 Gene

Gene Ontology (GO) - Biological Process for SRSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IDA 22767602
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 24440982
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006376 mRNA splice site selection IMP,TAS 12549914
genes like me logo Genes that share ontologies with SRSF6: view

No data available for SIGNOR curated interactions for SRSF6 Gene

Transcripts for SRSF6 Gene

mRNA/cDNA for SRSF6 Gene

Unigene Clusters for SRSF6 Gene

Serine/arginine-rich splicing factor 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for SRSF6 Gene

GeneLoc Exon Structure for
SRSF6
ECgene alternative splicing isoforms for
SRSF6

Expression for SRSF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRSF6 Gene

Protein differential expression in normal tissues from HIPED for SRSF6 Gene

This gene is overexpressed in Fetal ovary (7.8), Stomach (6.8), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF6 Gene



Protein tissue co-expression partners for SRSF6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF6 Gene:

SRSF6

SOURCE GeneReport for Unigene cluster for SRSF6 Gene:

Hs.725336
genes like me logo Genes that share expression patterns with SRSF6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRSF6 Gene

Orthologs for SRSF6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF6 34 35
  • 96.61 (n)
dog
(Canis familiaris)
Mammalia SRSF6 34 35
  • 92.94 (n)
cow
(Bos Taurus)
Mammalia SRSF6 34 35
  • 92.08 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF6 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf6 34
  • 91.02 (n)
mouse
(Mus musculus)
Mammalia Srsf6 34 16 35
  • 89.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF6 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF6 34 35
  • 74.82 (n)
lizard
(Anolis carolinensis)
Reptilia SRSF6 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3160 34
African clawed frog
(Xenopus laevis)
Amphibia b52-prov 34
zebrafish
(Danio rerio)
Actinopterygii srsf6b 35
  • 72 (a)
OneToMany
srsf6a 35
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-1 35
  • 52 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 35
  • 18 (a)
OneToMany
Species where no ortholog for SRSF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF6 Gene

ENSEMBL:
Gene Tree for SRSF6 (if available)
TreeFam:
Gene Tree for SRSF6 (if available)

Paralogs for SRSF6 Gene

Paralogs for SRSF6 Gene

(8) SIMAP similar genes for SRSF6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SRSF6 Gene

genes like me logo Genes that share paralogs with SRSF6: view

Variants for SRSF6 Gene

Sequence variations from dbSNP and Humsavar for SRSF6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_035489 A colorectal cancer sample
rs11086877 -- 43,456,986(+) CAGGC(A/G)TTGGC upstream-variant-2KB
rs111440404 -- 43,461,126(+) CTTCC(A/G)TGTTT nc-transcript-variant, utr-variant-3-prime
rs111582135 -- 43,461,406(+) GGTTT(G/T)TTTGT nc-transcript-variant, utr-variant-3-prime
rs111648437 -- 43,460,408(+) TAATT(-/TCG)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF6 Gene

Variant ID Type Subtype PubMed ID
nsv1057847 CNV loss 25217958
nsv1160678 CNV deletion 26073780
nsv586029 CNV gain 21841781

Variation tolerance for SRSF6 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF6 Gene

Disorders for SRSF6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SRSF6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
herpes gestationis
  • gestational herpes
behcet syndrome
  • behcet's disease
- elite association - COSMIC cancer census association via MalaCards
Search SRSF6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRSF6

Genetic Association Database (GAD)
SRSF6
Human Genome Epidemiology (HuGE) Navigator
SRSF6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF6
genes like me logo Genes that share disorders with SRSF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF6 Gene

Publications for SRSF6 Gene

  1. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton G.R. … Krainer A.R. (EMBO J. 1995) 2 3 4 22 64
  2. SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. (PMID: 12549914) Tran Q. … Roesser J.R. (Biochemistry 2003) 3 4 22 64
  3. Splicing factor SRSF6 promotes hyperplasia of sensitized skin. (PMID: 24440982) Jensen M.A. … Krainer A.R. (Nat. Struct. Mol. Biol. 2014) 3 4 64
  4. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. (PMID: 22767602) Yin X. … Liu F. (J. Biol. Chem. 2012) 3 4 64
  5. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3 64

Products for SRSF6 Gene

Sources for SRSF6 Gene

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