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Aliases for SRSF6 Gene

Aliases for SRSF6 Gene

  • Serine/Arginine-Rich Splicing Factor 6 2 3
  • SFRS6 3 4 6
  • SRP55 3 4 6
  • Splicing Factor, Arginine/Serine-Rich 6 2 4
  • Pre-MRNA-Splicing Factor SRP55 3 4
  • SR Splicing Factor 6 2 3
  • Splicing Factor, Arginine/Serine-Rich, 55 KDa 3
  • Epididymis Secretory Protein Li 91 3
  • Pre-MRNA Splicing Factor SRP55 2
  • HEL-S-91 3
  • B52 3

External Ids for SRSF6 Gene

Previous HGNC Symbols for SRSF6 Gene

  • SFRS6

Previous GeneCards Identifiers for SRSF6 Gene

  • GC20P042087
  • GC20P038822

Summaries for SRSF6 Gene

Entrez Gene Summary for SRSF6 Gene

  • The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF6 Gene

SRSF6 (Serine/Arginine-Rich Splicing Factor 6) is a Protein Coding gene. Diseases associated with SRSF6 include denys-drash syndrome. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF4.

UniProtKB/Swiss-Prot for SRSF6 Gene

  • Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

Gene Wiki entry for SRSF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF6 Gene

Genomics for SRSF6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRSF6 Gene

Start:
43,457,864 bp from pter
End:
43,464,247 bp from pter
Size:
6,384 bases
Orientation:
Plus strand

Genomic View for SRSF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF6 Gene

No data available for Regulatory Elements for SRSF6 Gene

Proteins for SRSF6 Gene

  • Protein details for SRSF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13247-SRSF6_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 6
    Protein Accession:
    Q13247
    Secondary Accessions:
    • B7Z6J3
    • E1P5W6
    • Q13244
    • Q13245
    • Q96J06
    • Q9UJB8
    • Q9Y3N7

    Protein attributes for SRSF6 Gene

    Size:
    344 amino acids
    Molecular mass:
    39587 Da
    Quaternary structure:
    • Binds SREK1/SFRS12. Interacts with DYRK1A.

    Alternative splice isoforms for SRSF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF6 Gene

Proteomics data for SRSF6 Gene at MOPED

Post-translational modifications for SRSF6 Gene

  • Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
  • Ubiquitination at Lys127, Lys143, and Lys165
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SRSF6 Gene

Domains for SRSF6 Gene

Gene Families for SRSF6 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF6 Gene

Suggested Antigen Peptide Sequences for SRSF6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13247

UniProtKB/Swiss-Prot:

SRSF6_HUMAN :
  • Q13247
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF6: view

Function for SRSF6 Gene

Molecular function for SRSF6 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

Gene Ontology (GO) - Molecular Function for SRSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 24440982
GO:0005515 protein binding IPI 25416956
GO:0036002 pre-mRNA binding IDA 12549914
genes like me logo Genes that share ontologies with SRSF6: view

Animal Model Products

CRISPR Products

miRNA for SRSF6 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRSF6 Gene

Localization for SRSF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF6 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF6 Gene COMPARTMENTS Subcellular localization image for SRSF6 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for SRSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA 22767602
genes like me logo Genes that share ontologies with SRSF6: view

Pathways for SRSF6 Gene

genes like me logo Genes that share pathways with SRSF6: view

Gene Ontology (GO) - Biological Process for SRSF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000380 alternative mRNA splicing, via spliceosome IDA 22767602
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 24440982
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
genes like me logo Genes that share ontologies with SRSF6: view

Transcripts for SRSF6 Gene

mRNA/cDNA for SRSF6 Gene

Unigene Clusters for SRSF6 Gene

Serine/arginine-rich splicing factor 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for SRSF6 Gene

GeneLoc Exon Structure for
SRSF6
ECgene alternative splicing isoforms for
SRSF6

Expression for SRSF6 Gene

mRNA expression in normal human tissues for SRSF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SRSF6 Gene

This gene is overexpressed in Fetal ovary (7.8), Stomach (6.8), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF6 Gene

SOURCE GeneReport for Unigene cluster for SRSF6 Gene Hs.725336

genes like me logo Genes that share expressions with SRSF6: view

Expression partners for SRSF6 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRSF6 Gene

Orthologs for SRSF6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRSF6 35
  • 92.08 (n)
  • 97.81 (a)
SRSF6 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF6 35
  • 92.94 (n)
  • 98.44 (a)
SRSF6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf6 35
  • 89.89 (n)
  • 97.52 (a)
Srsf6 16
Srsf6 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRSF6 35
  • 96.61 (n)
  • 95.64 (a)
SRSF6 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf6 35
  • 91.02 (n)
  • 97.52 (a)
oppossum
(Monodelphis domestica)
Mammalia SRSF6 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF6 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF6 35
  • 74.82 (n)
  • 86.07 (a)
SRSF6 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF6 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3160 35
African clawed frog
(Xenopus laevis)
Amphibia b52-prov 35
zebrafish
(Danio rerio)
Actinopterygii srsf6a 36
  • 68 (a)
OneToMany
srsf6b 36
  • 72 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-1 36
  • 52 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 36
  • 18 (a)
OneToMany
Species with no ortholog for SRSF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF6 Gene

ENSEMBL:
Gene Tree for SRSF6 (if available)
TreeFam:
Gene Tree for SRSF6 (if available)

Paralogs for SRSF6 Gene

Paralogs for SRSF6 Gene

Selected SIMAP similar genes for SRSF6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for SRSF6 Gene

genes like me logo Genes that share paralogs with SRSF6: view

Variants for SRSF6 Gene

Sequence variations from dbSNP and Humsavar for SRSF6 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs9208 -- 43,463,294(+) TGGCT(C/T)ACTTG utr-variant-3-prime, nc-transcript-variant
rs12264 -- 43,462,717(-) CAGGA(A/G)TTTCT utr-variant-3-prime, nc-transcript-variant
rs14957 -- 43,463,569(-) AAGCA(A/C)AAAAT utr-variant-3-prime, nc-transcript-variant
rs2235611 -- 43,460,871(-) TCTTT(A/G)GGGGA synonymous-codon, reference, nc-transcript-variant
rs2294595 -- 43,463,908(-) TATTT(A/G)TAAAT downstream-variant-500B

Relevant External Links for SRSF6 Gene

HapMap Linkage Disequilibrium report
SRSF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SRSF6 Gene

Disorders for SRSF6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SRSF6 Gene in MalaCards »

(1) Diseases for SRSF6 Gene including...

(1) University of Copenhagen DISEASES for SRSF6 Gene

Relevant External Links for SRSF6

Genetic Association Database (GAD)
SRSF6
Human Genome Epidemiology (HuGE) Navigator
SRSF6
genes like me logo Genes that share disorders with SRSF6: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for SRSF6 Gene

Publications for SRSF6 Gene

  1. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton G.R. … Krainer A.R. (EMBO J. 1995) 2 3 4 23
  2. SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. (PMID: 12549914) Tran Q. … Roesser J.R. (Biochemistry 2003) 3 4 23
  3. SR proteins: a conserved family of pre-mRNA splicing factors. (PMID: 1577277) Zahler A.M. … Roth M.B. (Genes Dev. 1992) 3 4
  4. Specific binding of an exonic splicing enhancer by the pre-mRNA splicing factor SRp55. (PMID: 9436904) Nagel R.J. … Zahler A.M. (RNA 1998) 3 23
  5. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PMID: 10757789) Barnard D.C. … Patton J.G. (Mol. Cell. Biol. 2000) 3 4

Products for SRSF6 Gene

Sources for SRSF6 Gene

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