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SRSF6 Gene

protein-coding   GIFtS: 56
GCID: GC20P042087

Serine/Arginine-Rich Splicing Factor 6

(Previous names: splicing factor, arginine/serine-rich 6)
(Previous symbol: SFRS6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine-Rich Splicing Factor 61 2     Pre-MRNA Splicing Factor SRP551
SFRS61 2 3 5     B522
Splicing Factor, Arginine/Serine-Rich 61 3     HEL-S-912
SR Splicing Factor 61 2     Epididymis Secretory Protein Li 912
Pre-MRNA-Splicing Factor SRP552 3     Splicing Factor, Arginine/Serine-Rich, 55 KDa2
SRP552 3     SRp555

External Ids:    HGNC: 107881   Entrez Gene: 64312   Ensembl: ENSG000001241937   OMIM: 6019445   UniProtKB: Q132473   

Export aliases for SRSF6 gene to outside databases

Previous GC identifer: GC20P038822


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRSF6 Gene:
The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of
alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to
bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript
variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found
for this gene.(provided by RefSeq, Sep 2010)

GeneCards Summary for SRSF6 Gene:
SRSF6 (serine/arginine-rich splicing factor 6) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF6_HUMAN, Q13247
Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Represses the splicing of MAPT/Tau exon 10

Gene Wiki entry for SRSF6 (SFRS6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF6 promoter sequence
   Search Chromatin IP Primers for SRSF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q13.11   HGNC cytogenetic band: 20q12-q13.1

SRSF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF6 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P042087:  view genomic region     (about GC identifiers)

Start:
42,086,504 bp from pter      End:
42,092,245 bp from pter
Size:
5,742 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRSF6_HUMAN, Q13247 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 6  
Size: 344 amino acids; 39587 Da
Subunit: Binds SREK1/SFRS12
Secondary accessions: B7Z6J3 E1P5W6 Q13244 Q13245 Q96J06 Q9UJB8 Q9Y3N7
Alternative splicing: 3 isoforms:  Q13247-1   Q13247-2   Q13247-3   

Explore the universe of human proteins at neXtProt for SRSF6: NX_Q13247

Explore proteomics data for SRSF6 at MOPED

Post-translational modifications: 

  • Extensively phosphorylated on serine residues in the RS domain (By similarity)1
  • Ubiquitination2 at Lys127, Lys143, Lys165
  • Modification sites at PhosphoSitePlus

  • See SRSF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006266.2  
    ENSEMBL proteins: 
     ENSP00000433544   ENSP00000244020  
    Reactome Protein details: Q13247

    SRSF6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SRSF6

     
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    antibodies-online proteins for SRSF6 (5 products) 

     
    antibodies-online peptides for SRSF6

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    antibodies-online antibodies for SRSF6 (13 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q13247

    ProtoNet protein and cluster: Q13247

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF6_HUMAN, Q13247
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with SRSF6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF6_HUMAN, Q13247
    Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
    Represses the splicing of MAPT/Tau exon 10

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA--
    GO:0036002pre-mRNA binding IDA12549914
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRSF6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SRSF6

    miRNA
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    miRTarBase miRNAs that target SRSF6:
    hsa-mir-26b-5p (MIRT029475), hsa-mir-18a-5p (MIRT050719), hsa-mir-1 (MIRT023804), hsa-mir-186-5p (MIRT021143)

    Block miRNA regulation of human, mouse, rat SRSF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF6 (see all 67):
    hsa-miR-193a-3p hsa-miR-642a hsa-miR-371-5p hsa-miR-877* hsa-miR-629* hsa-miR-298 hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSRSF6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRSF6

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRSF6_HUMAN, Q13247: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IDA--

    Find genes that share ontologies with SRSF6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRSF6 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SRSF6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF6
        mRNA processing

    5 Reactome Pathways for SRSF6
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region
    mRNA Splicing - Minor Pathway


    2 Kegg Pathways  (Kegg details for SRSF6):
        Spliceosome
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF6
    Interactions:

        Search GeneGlobe Interaction Network for SRSF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRSF6 (Q132472, 3 ENSP000002440204) via UniProtKB, MINT, STRING, and/or I2D (see all 776)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205746 I2D: score=1 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    PKP3Q9Y4462, 3MINT-7945693 I2D: score=1 
    SRSF4Q081702, 3, ENSP000003629004MINT-67374 I2D: score=5 STRING: ENSP00000362900
    RNPS1Q152872, 3, ENSP000003158594MINT-66637 I2D: score=5 STRING: ENSP00000315859
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000380alternative mRNA splicing, via spliceosome IDA--
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IMP--
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--

    Find genes that share ontologies with SRSF6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRSF6 gene: 
    NM_006275.5  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483871(uc002xki.3) ENST00000244020(uc010zwg.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat SRSF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF6 (see all 67):
    hsa-miR-193a-3p hsa-miR-642a hsa-miR-371-5p hsa-miR-877* hsa-miR-629* hsa-miR-298 hsa-miR-3613-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidSRSF6 3' UTR sequence
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF6
      QuantiTect SYBR Green Assays in human, mouse, rat SRSF6
      QuantiFast Probe-based Assays in human, mouse, rat SRSF6

    Selected AceView cDNA sequences (see all 413):

    CB215404 T33114 BP334718 AA104026 BM788391 NM_006275 AA935163 CB151393 
    Z45281 CA777448 BQ214840 CB267483 BG743153 CR606848 BQ574892 W21252 
    AU120210 BM969760 BM761335 AV704620 AI675764 AI265828 AW470393 AA884249 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRSF6 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
    SP1:                                -                 -     -                                                   
    SP2:                                -     -     -     -     -                                                   
    SP3:                                -     -     -     -     -                             -     -     -         
    SP4:                                -     -           -     -                                                   
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SRSF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRSF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGTAGTGCC
    SRSF6 Expression
    About this image


    SRSF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SRSF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF6 Protein Expression
        Custom PCR Arrays for SRSF6
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SRSF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SRSF6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf61 , 5 serine/arginine-rich splicing factor 61, 5 89.89(n)1
    97.52(a)1
      2 (83.87 cM)5
    679961  NM_026499.41  NP_080775.31 
     1629315285 
    chicken
    (Gallus gallus)
    Aves SRSF61 serine/arginine-rich splicing factor 6 74.82(n)
    86.07(a)
      419116  NM_001030843.2  NP_001026014.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF66
    serine/arginine-rich splicing factor 6
    87(a)
    1 ↔ 1
    GL343365.1(501435-510157)
    African clawed frog
    (Xenopus laevis)
    Amphibia b52-prov2 splicing factor, arginine/serine-rich 6 73.58(n)    BC044265.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055238.12   -- 79.95(n)    BC055238.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-16
    Protein RSP-1, isoform a
    52(a)
    many ↔ many
    II(11453980-11455807) WBGene00004698
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NPL36
    RNA-binding protein that promotes elongation, regu...
    18(a)
    1 → many
    IV(1328783-1330027) YDR432W


    ENSEMBL Gene Tree for SRSF6 (if available)
    TreeFam Gene Tree for SRSF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRSF6 gene
    SRSF52  SRSF92  SRSF72  SRSF12  SRSF42  SRSF32  
    8 SIMAP similar genes for SRSF6 using alignment to 2 protein entries:     SRSF6_HUMAN (see all proteins):
    SFRS6    SRSF4    SFRS4    SRSF5    SFRS5    SRSF1
    SRSF2    SRSF9

    Find genes that share paralogs with SRSF6           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SRSF6
    PGOHUM00000236934 PGOHUM00000241733 PGOHUM00000241734


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRSF6 (see all 250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354894
    A colorectal cancer sample4--see VAR_0354892 R Q mis40--------
    rs1508047001,2
    C--42053905(+) AGGTTG/TCAGGG 2 -- us2k10--------
    rs1921813101,2
    --42053933(+) GACATA/GGACAT 2 -- us2k10--------
    rs1400214181,2
    --42053979(+) AAGAGA/GTGAAG 2 -- us2k10--------
    rs754644991,2
    C,F--42054028(+) TTTCCC/TGTCTA 2 -- us2k11Minor allele frequency- T:0.08NA 120
    rs1837922831,2
    --42054215(+) AACCCA/GCTCGG 2 -- us2k10--------
    rs1892055101,2
    --42054236(+) ACGCTG/TCGGAA 2 -- us2k10--------
    rs1419883131,2
    --42054252(+) GTTCTC/TTCCTT 2 -- us2k10--------
    rs1922793911,2
    C--42054284(+) TTGTCA/GCCCAG 2 -- us2k10--------
    rs1463196291,2
    --42054285(+) TGTCAC/TCCAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRSF6 (42086504 - 42092245 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SRSF6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF6
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601944    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SRSF6:
    Denys-Drash syndrome

    Find genes that share disorders with SRSF6           About GenesLikeMe

    Genetic Association Database (GAD): SRSF6
    Human Genome Epidemiology (HuGE) Navigator: SRSF6 (3 documents)

    Export disorders for SRSF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRSF6 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with SRSF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PubMed id 7556075)1, 2, 3, 9 Screaton G.R.... Krainer A.R. (EMBO J. 1995)
    2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)1, 2 Wang J.... Andreadis A. (J. Neurochem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PubMed id 10757789)1, 2 Barnard D.C. and Patton J.G. (Mol. Cell. Biol. 2000)
    9. SR proteins: a conserved family of pre-mRNA splicing factors. (PubMed id 1577277)1, 2 Zahler A.M.... Roth M.B. (Genes Dev. 1992)
    10. SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. (PubMed id 12549914)1, 9 Tran Q. and Roesser J.R. (Biochemistry 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6431 HGNC: 10788 AceView: SFRS6 Ensembl:ENSG00000124193 euGenes: HUgn6431
    ECgene: SRSF6 Kegg: 6431 H-InvDB: SRSF6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRSF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SRSF6 gene:
    Search GeneIP for patents involving SRSF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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