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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF6 Gene

protein-coding   GIFtS: 60
GCID: GC20P042087

Serine/Arginine-Rich Splicing Factor 6

(Previous names: splicing factor, arginine/serine-rich 6)
(Previous symbol: SFRS6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 61 2     SRP552 3
SFRS61 2 3     Pre-MRNA Splicing Factor SRP551
Splicing Factor, Arginine/Serine-Rich 61 3     B522
SR Splicing Factor 61 2     Splicing Factor, Arginine/Serine-Rich, 55 KDa2
Pre-MRNA-Splicing Factor SRP552 3     

External Ids:    HGNC: 107881   Entrez Gene: 64312   Ensembl: ENSG000001241937   OMIM: 6019445   UniProtKB: Q132473   
ORGUL members:         
NONCODE14:n409625      

Export aliases for SRSF6 gene to outside databases

Previous GC identifer: GC20P038822


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF6 Gene:
The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of
alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to
bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript
variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found
for this gene.(provided by RefSeq, Sep 2010)

GeneCards Summary for SRSF6 Gene: 
SRSF6 (serine/arginine-rich splicing factor 6) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SRSF6 include denys-drash syndrome, and progeria, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF6_HUMAN, Q13247
Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Represses the splicing of MAPT/Tau exon 10

Gene Wiki entry for SRSF6 (SFRS6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q13.11   HGNC cytogenetic band: 20q12-q13.1

SRSF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF6 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P042087:  view genomic region     (about GC identifiers)

Start:
42,086,504 bp from pter      End:
42,092,245 bp from pter
Size:
5,742 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRSF6_HUMAN, Q13247 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 6  
Size: 344 amino acids; 39587 Da
Subunit: Binds SREK1/SFRS12
Subcellular location: Nucleus
Secondary accessions: B7Z6J3 E1P5W6 Q13244 Q13245 Q96J06 Q9UJB8 Q9Y3N7
Alternative splicing: 3 isoforms:  Q13247-1   Q13247-2   Q13247-3   

Explore the universe of human proteins at neXtProt for SRSF6: NX_Q13247

Explore proteomics data for SRSF6 at MOPED 

Post-translational modifications:

  • UniProtKB: Extensively phosphorylated on serine residues in the RS domain (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13247

  • SRSF6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRSF6 Protein Expression
    REFSEQ proteins: NP_006266.2  
    ENSEMBL proteins: 
     ENSP00000433544   ENSP00000244020  
    Reactome Protein details: Q13247
    Human Recombinant Protein Products for SRSF6: 
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    Cloud-Clone Corp. Proteins for SRSF6 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    SRSF6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q13247

    ProtoNet protein and cluster: Q13247

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF6_HUMAN, Q13247
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    SRSF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF6_HUMAN, Q13247
    Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
    Represses the splicing of MAPT/Tau exon 10

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    SRSF6 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRSF6 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    mRNA Splicing0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF6
        mRNA processing

    5/15        Reactome Pathways for SRSF6 (see all 15)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    2         Kegg Pathways  (Kegg details for SRSF6):
        Spliceosome
    Herpes simplex infection


    SRSF6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/677 Interacting proteins for SRSF6 (Q132472, 3 ENSP000002440204) via UniProtKB, MINT, STRING, and/or I2D (see all 677)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205746 I2D: score=1 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    PKP3Q9Y4462, 3MINT-7945693 I2D: score=1 
    SF3B4Q154272, ENSP000002716284MINT-7945693 MINT-8333834 STRING: ENSP00000271628
    SRSF4Q081702, 3, ENSP000003629004MINT-67374 I2D: score=5 STRING: ENSP00000362900
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006376mRNA splice site selection TAS7556075
    GO:0006406mRNA export from nucleus TAS--

    SRSF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF6

    Search CenterWatch for drugs/clinical trials and news about SRSF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRSF6 gene: 
    NM_006275.5  

    Unigene Cluster for SRSF6:

    Serine/arginine-rich splicing factor 6
    Hs.725336  [show with all ESTs]
    Unigene Representative Sequence: NR_034009
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483871(uc002xki.3) ENST00000244020(uc010zwg.2)
    miRNA
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    Additional mRNA sequence: 

    AB208976.1 AB451251.1 AB451375.1 AK291203.1 AK300411.1 AL110214.1 BC006832.2 NR_034009.1 
    U30883.1 

    24/29 DOTS entries (see all 29):

    DT.97854866  DT.448577  DT.92409366  DT.97854864  DT.100784554  DT.95370090  DT.95370104  DT.100784556 
    DT.120805126  DT.95283191  DT.95370098  DT.95370101  DT.100883699  DT.101961741  DT.86852259  DT.91769129 
    DT.91840278  DT.91984878  DT.92455309  DT.95370105  DT.100038540  DT.100740045  DT.100843141  DT.100883692 

    24/413 AceView cDNA sequences (see all 413):

    W21252 BM722066 AA906661 BM761335 AI122997 CD622297 BQ574892 AA721164 
    CA431262 CA448140 CR606848 BM969760 AA653526 AU185323 BG566261 BM677620 
    AA884249 CA944642 AW953084 W84315 BU681811 AV704620 CB267483 AA010892 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF6 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
    SP1:                                -                 -     -                                                   
    SP2:                                -     -     -     -     -                                                   
    SP3:                                -     -     -     -     -                             -     -     -         
    SP4:                                -     -           -     -                                                   
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for SRSF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF6 expression in normal human tissues (normalized intensities)      SRSF6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGTAGTGCC
    SRSF6 Expression
    About this image


    SRSF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See SRSF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF6

    SOURCE GeneReport for Unigene cluster: Hs.725336
        SABiosciences Custom PCR Arrays for SRSF6
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRSF6 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf61 , 5 serine/arginine-rich splicing factor 61, 5 89.38(n)1
    97.64(a)1
      2 (83.87 cM)5
    679961  NM_026499.41  NP_080775.31 
     1629315285 
    chicken
    (Gallus gallus)
    Aves SRSF61 serine/arginine-rich splicing factor 6 79.98(n)
    91.55(a)
      419116  NM_001030843.2  NP_001026014.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF66
    serine/arginine-rich splicing factor 6
    87(a)
    1 ↔ 1
    GL343365.1(501435-510157)
    African clawed frog
    (Xenopus laevis)
    Amphibia b52-prov2 splicing factor, arginine/serine-rich 6 73.58(n)    BC044265.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055238.12   -- 79.95(n)    BC055238.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta B521 B52 57.76(n)
    66.35(a)
      41670  NM_176488.2  NP_788665.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-11 Protein RSP-1 53.64(n)
    58.1(a)
      174748  NM_064041.3  NP_496442.1 


    ENSEMBL Gene Tree for SRSF6 (if available)
    TreeFam Gene Tree for SRSF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF6 gene
    SRSF52  SRSF92  SRSF72  SRSF12  SRSF42  SRSF32  
    8 SIMAP similar genes for SRSF6 using alignment to 2 protein entries:     SRSF6_HUMAN (see all proteins):
    SFRS6    SRSF4    SFRS4    SRSF5    SFRS5    SRSF1
    SRSF2    SRSF9

    SRSF6 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for SRSF6
    PGOHUM00000236934 PGOHUM00000241733 PGOHUM00000241734


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/250 SNPs in SRSF6 are shown (see all 250)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354894
    A colorectal cancer sample4--see VAR_0354892 R Q mis40--------
    rs1508047001,2
    C--42053905(+) AGGTTG/TCAGGG 2 -- us2k10--------
    rs1921813101,2
    --42053933(+) GACATA/GGACAT 2 -- us2k10--------
    rs1400214181,2
    --42053979(+) AAGAGA/GTGAAG 2 -- us2k10--------
    rs754644991,2
    C,F--42054028(+) TTTCCC/TGTCTA 2 -- us2k11Minor allele frequency- T:0.08NA 120
    rs1837922831,2
    --42054215(+) AACCCA/GCTCGG 2 -- us2k10--------
    rs1892055101,2
    --42054236(+) ACGCTG/TCGGAA 2 -- us2k10--------
    rs1419883131,2
    --42054252(+) GTTCTC/TTCCTT 2 -- us2k10--------
    rs1922793911,2
    C--42054284(+) TTGTCA/GCCCAG 2 -- us2k10--------
    rs1463196291,2
    --42054285(+) TGTCAC/TCCAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SRSF6 (42086504 - 42092245 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SRSF6: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF6
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601944    OMIM disorders: --

    10 diseases for SRSF6:    About MalaCards
    denys-drash syndrome    progeria    familial hypercholesterolemia    frontotemporal dementia
    hypercholesterolemia    dementia    schizophrenia    gastric cancer
    melanoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SRSF6:
    Denys-Drash syndrome

    SRSF6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRSF6
    Human Genome Epidemiology (HuGE) Navigator: SRSF6 (3 documents)

    Export disorders for SRSF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF6 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with SRSF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PubMed id 7556075)1, 2, 3, 9 Screaton G.R.... Krainer A.R. (1995)
    2. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)1, 2 Wang J....Andreadis A. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PubMed id 10757789)1, 2 Barnard D.C. and Patton J.G. (2000)
    9. SR proteins: a conserved family of pre-mRNA splicing factors. (PubMed id 1577277)1, 2 Zahler A.M.... Roth M.B. (1992)
    10. SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. (PubMed id 12549914)1, 9 Tran Q. and Roesser J.R. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6431 HGNC: 10788 AceView: SFRS6 Ensembl:ENSG00000124193 euGenes: HUgn6431
    ECgene: SRSF6 Kegg: 6431 H-InvDB: SRSF6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRSF6 gene:
    Search GeneIP for patents involving SRSF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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