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Aliases for SRSF5 Gene

Aliases for SRSF5 Gene

  • Serine/Arginine-Rich Splicing Factor 5 2 3
  • Splicing Factor, Arginine/Serine-Rich 5 2 3 4
  • SFRS5 3 4 6
  • SRP40 3 4 6
  • Pre-MRNA-Splicing Factor SRP40 3 4
  • Delayed-Early Protein HRS 3 4
  • SR Splicing Factor 5 2 3
  • HRS 3 4

External Ids for SRSF5 Gene

Previous Symbols for SRSF5 Gene

  • SFRS5

Summaries for SRSF5 Gene

Entrez Gene Summary for SRSF5 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF5 Gene

SRSF5 (Serine/Arginine-Rich Splicing Factor 5) is a Protein Coding gene. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and RS domain binding. An important paralog of this gene is SRSF4.

UniProtKB/Swiss-Prot for SRSF5 Gene

  • Plays a role in constitutive splicing and can modulate the selection of alternative splice sites

Gene Wiki entry for SRSF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF5 Gene

Genomics for SRSF5 Gene

Genomic Location for SRSF5 Gene

Start:
69,726,900 bp from pter
End:
69,772,005 bp from pter
Size:
45,106 bases
Orientation:
Plus strand

Genomic View for SRSF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF5 Gene

No data available for Regulatory Elements for SRSF5 Gene

Proteins for SRSF5 Gene

  • Protein details for SRSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13243-SRSF5_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 5
    Protein Accession:
    Q13243
    Secondary Accessions:
    • O14797
    • Q16662
    • Q49AD6
    • Q6FGE0

    Protein attributes for SRSF5 Gene

    Size:
    272 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.
    SequenceCaution:
    • Sequence=AAC39543.1; Type=Frameshift; Positions=113, 140; Evidence={ECO:0000305};

    Alternative splice isoforms for SRSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF5 Gene

Proteomics data for SRSF5 Gene at MOPED

Post-translational modifications for SRSF5 Gene

Other Protein References for SRSF5 Gene

No data available for DME Specific Peptides for SRSF5 Gene

Domains for SRSF5 Gene

Gene Families for SRSF5 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF5 Gene

UniProtKB/Swiss-Prot:

SRSF5_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • Q13243
Family:
  • Belongs to the splicing factor SR family.:
    • Q13243
genes like me logo Genes that share domains with SRSF5: view

Function for SRSF5 Gene

Molecular function for SRSF5 Gene

UniProtKB/Swiss-Prot Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites

Gene Ontology (GO) - Molecular Function for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 12762840
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0050733 RS domain binding IEA --
genes like me logo Genes that share ontologies with SRSF5: view

miRNA for SRSF5 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRSF5 Gene

Localization for SRSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF5 Gene COMPARTMENTS Subcellular localization image for SRSF5 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0016607 nuclear speck ISS --
genes like me logo Genes that share ontologies with SRSF5: view

Pathways for SRSF5 Gene

genes like me logo Genes that share pathways with SRSF5: view

Gene Ontology (GO) - Biological Process for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006376 mRNA splice site selection TAS 7556075
GO:0006397 mRNA processing TAS 7556075
genes like me logo Genes that share ontologies with SRSF5: view

Compounds for SRSF5 Gene

(3) Novoseek inferred chemical compound relationships for SRSF5 Gene

Compound -log(P) Hits PubMed IDs
serine 43.7 6
arginine 34.4 1
phosphatidylinositol 17.7 2
genes like me logo Genes that share compounds with SRSF5: view

Transcripts for SRSF5 Gene

Unigene Clusters for SRSF5 Gene

Serine/arginine-rich splicing factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - -
SP17: - - - -
SP18: - - - -
SP19: - - - -
SP20: - - -
SP21:
SP22: - - -
SP23: -
SP24:
SP25:

ExUns: 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for SRSF5 Gene

GeneLoc Exon Structure for
SRSF5
ECgene alternative splicing isoforms for
SRSF5

Expression for SRSF5 Gene

mRNA expression in normal human tissues for SRSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF5 Gene

SOURCE GeneReport for Unigene cluster for SRSF5 Gene Hs.632326

genes like me logo Genes that share expressions with SRSF5: view

Orthologs for SRSF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF5 36
  • 100 (n)
  • 100 (a)
SRSF5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS5 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF5 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf5 16
Srsf5 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRSF5 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF5 37
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF5 36
  • 81.46 (n)
  • 94.94 (a)
SRSF5 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF5 37
  • 98 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5499 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8018 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8311 36
zebrafish
(Danio rerio)
Actinopterygii Dr.11695 36
srsf5b 37
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta B52 37
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsp-5 37
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 37
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToMany
CSA.9965 37
  • 53 (a)
OneToMany
Species with no ortholog for SRSF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF5 Gene

ENSEMBL:
Gene Tree for SRSF5 (if available)
TreeFam:
Gene Tree for SRSF5 (if available)

Paralogs for SRSF5 Gene

Paralogs for SRSF5 Gene

genes like me logo Genes that share paralogs with SRSF5: view

Variants for SRSF5 Gene

Sequence variations from dbSNP and Humsavar for SRSF5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1057683 - 69,771,032(+) AGAAT(G/T)CTATT reference, missense, nc-transcript-variant
rs1802832 -- 69,771,860(+) GGACA(C/T)TTAAA utr-variant-3-prime
rs2148504 -- 69,770,525(+) CCGAC(C/T)TAAAT reference, missense, nc-transcript-variant
rs2992409 -- 69,765,205(-) gatcc(A/G)cccgc upstream-variant-2KB
rs3208848 -- 69,771,542(+) AAATT(C/T)TGGTA utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SRSF5 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV Gain 19166990

Relevant External Links for SRSF5 Gene

HapMap Linkage Disequilibrium report
SRSF5

Disorders for SRSF5 Gene

(1) University of Copenhagen DISEASES for SRSF5 Gene

Relevant External Links for SRSF5

Human Genome Epidemiology (HuGE) Navigator
SRSF5
genes like me logo Genes that share disorders with SRSF5: view

No data available for UniProtKB/Swiss-Prot for SRSF5 Gene

Publications for SRSF5 Gene

  1. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. (PMID: 9434190) Du K. … Taub R. (Gene 1997) 3 4 23
  2. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton G.R. … Krainer A.R. (EMBO J. 1995) 3 4 23
  3. Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. (PMID: 12665590) Guil S. … Bach-Elias M. (Mol. Cell. Biol. 2003) 3 23
  4. Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA. (PMID: 15123677) Ropers D. … StAcvenin J. (J. Biol. Chem. 2004) 3 23
  5. Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. (PMID: 16000324) Venables J.P. … Elliott D.J. (Hum. Mol. Genet. 2005) 3 23

Products for SRSF5 Gene

Sources for SRSF5 Gene

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