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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF5 Gene

protein-coding   GIFtS: 56
GCID: GC14P070234

serine/arginine-rich splicing factor 5

(Previous names: splicing factor, arginine/serine-rich 5 )
(Previous symbol: SFRS5)
 Explore 9 diseases affiliated with
SRSF5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SRSF5    

Aliases
for SRSF5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Serine/Arginine-Rich Splicing Factor 51 2     SRP401 2 3
Splicing Factor, Arginine/Serine-Rich 51 2 3     Delayed-Early Protein HRS2 3
HRS1 2 3     Pre-MRNA-Splicing Factor SRP402 3
SFRS51 2 3     SR Splicing Factor 52

External Ids:    HGNC: 107871   Entrez Gene: 64302   Ensembl: ENSG000001006507   OMIM: 6009145   UniProtKB: Q132433   

Export aliases for SRSF5 gene to outside databases

Previous GC identifer: GC14P050402


Summaries
for SRSF5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SRSF5:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,
which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding
RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates
interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins
have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: SRSF5_HUMAN, Q13243
Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites

Gene Wiki entry for SRSF5 (SFRS5)


Genomic Views
for SRSF5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRSF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q24

SRSF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF5 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P070234:  view genomic region     (about GC identifiers)

Start:
 70,193,617 bp from pter      End:
 70,238,722 bp from pter
Size:
 45,106 bases      Orientation:
 plus strand

Proteins
for SRSF5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRSF5_HUMAN, Q13243 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 5  
Size: 272 amino acids; 31264 Da
Subunit: Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex
with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2
Subcellular location: Nucleus
Sequence caution: Sequence=AAC39543.1; Type=Frameshift; Positions=113, 140;
Secondary accessions: O14797 Q16662 Q49AD6 Q6FGE0
Alternative splicing: 4 isoforms:  Q13243-1   Q13243-2   Q13243-4   Q13243-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF5: NX_Q13243

Post-translational modifications:

  • Extensively phosphorylated on serine residues in the RS domain (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13243

    • SRSF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034554.1  NP_008856.2  

    ENSEMBL proteins: 
     ENSP00000452123   ENSP00000377892   ENSP00000452400   ENSP00000452449   ENSP00000451088  
     ENSP00000451391   ENSP00000452090   ENSP00000450918   ENSP00000402734  
    Reactome Protein details: Q13243
    Human Recombinant Protein Products: 
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    Novus Biologicals SRSF5 Proteins
    Novus Biologicals SRSF5 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SRSF5

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck ISS--


    SRSF5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SRSF5

    Protein Domains /
    Families
    for SRSF5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRSF5 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q13243

    ProtoNet protein and cluster: Q13243

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF5_HUMAN, Q13243
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for SRSF5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SRSF5_HUMAN, Q13243
    Function: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites

    miRNA
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    hsa-miR-181c hsa-miR-1283 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-181a hsa-miR-181d hsa-miR-1305 hsa-miR-374c
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    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12762840
    GO:0050733RS domain binding ----


    SRSF5 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SRSF5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing1.00
    		mRNA Processing0.82
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		Spliceosome0.31
    2RNA Polymerase II Transcription Termination
    		RNA Polymerase II Transcription Termination1.00
    		Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    		Post-Elongation Processing of the Transcript1.00
    		mRNA 3'-end processing0.79
    		Cleavage of Growing Transcript in the Termination Region 1.00
    3Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    4Transport of Mature Transcript to Cytoplasm
    		Transport of Mature Transcript to Cytoplasm1.00
    		Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    5Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for SRSF5 
        mRNA processing

    5/14        Reactome Pathways for SRSF5 (see all 14)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    1         Kegg Pathway  (Kegg details for SRSF5):
        Spliceosome


    SRSF5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/661 Interacting proteins for SRSF5 (Q132432, 3 ENSP000003778924) via UniProtKB, MINT, STRING, and/or I2D (see all 661)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205737 I2D: score=1 STRING: ENSP00000221494
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 I2D: score=1 STRING: ENSP00000326261
    TNK2Q079122, 3MINT-64703 I2D: score=3 
    MAPK6Q166592, 3MINT-8261945 I2D: score=2 
    CALM1P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006376mRNA splice site selection TAS7556075
    GO:0006397mRNA processing TAS7556075


    SRSF5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRSF5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRSF5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF5
    3 Novoseek chemical compound relationships for SRSF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 43.7 8 11283022 (2), 11815617 (1), 20304996 (1), 10857791 (1) (see all 5)
    arginine 34.4 1 10857791 (1)
    phosphatidylinositol 17.7 2 11283022 (2)

    Search CenterWatch for drugs/clinical trials and news about SRSF5 

    Transcripts
    for SRSF5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SRSF5 gene (2 alternative transcripts): 
    NM_001039465.1  NM_006925.3  

    Unigene Cluster for SRSF5:

    Serine/arginine-rich splicing factor 5
    Hs.632326  [show with all ESTs]
    Unigene Representative Sequence: BC040209
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000553521(uc021rvj.1 uc001xll.3 uc001xlp.3) ENST00000394366(uc001xlo.3)
    ENST00000554465(uc001xln.1) ENST00000553548 ENST00000553369 ENST00000557435
    ENST00000557337 ENST00000557154 ENST00000553635 ENST00000556184 ENST00000557460
    ENST00000556587 ENST00000555547 ENST00000556436 ENST00000555412 ENST00000555349
    ENST00000554021 ENST00000556330

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF5 (see all 16):
    hsa-miR-181c hsa-miR-1283 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-181a hsa-miR-181d hsa-miR-1305 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmid: SRSF5 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB451250.1 AB451374.1 AF070562.1 AK296113.1 AK300560.1 AK311805.1 BC018823.2 BC029984.2 
    BC040209.1 BT007089.1 CR542167.1 CR542182.1 HQ292181.1 U30826.1 U30884.1 

    24/49 DOTS entries (see all 49):

    DT.100685580  DT.95169771  DT.100685567  DT.95169753  DT.100039144  DT.95169772  DT.100763204  DT.120761932 
    DT.120761839  DT.100685578  DT.120761893  DT.97821684  DT.87015660  DT.100685568  DT.100874110  DT.91779384 
    DT.95169768  DT.100685569  DT.95169777  DT.100649371  DT.95169746  DT.100685563  DT.120761897  DT.100858368 

    24/851 AceView cDNA sequences (see all 851):

    AI686802 CA421616 BM478118 BM264281 AF070562 AI446204 BM966793 AW770003 
    H04117 AI858158 CR598816 BM449900 BQ773613 AW571595 AV652000 AI708628 
    AW264708 AW949461 H68659 AW016512 BM671952 BP353220 BG292426 BM698317 

    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF5 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^
    SP1:                                                  -     -                 -                                   -     -     -     -           -     -     -   
    SP2:                                            -     -     -                 -                                   -     -     -     -           -     -     -   
    SP3:                                            -     -     -                 -                                   -     -     -     -           -     -     -   
    SP4:                                            -     -     -                 -     -                             -     -     -     -           -     -     -   
    SP5:                                            -     -     -                 -                                   -     -     -     -           -     -     -   

    ExUns: 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:  -     -     -     -                 -                           
    SP2:  -     -     -     -                 -                           
    SP3:  -     -     -     -                 -                           
    SP4:  -     -     -     -                 -                           
    SP5:  -     -     -     -                 -                           


    ECgene alternative splicing isoforms for SRSF5

    Expression
    for SRSF5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGACAAGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SRSF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF5

    SOURCE GeneReport for Unigene cluster: Hs.632326
        SABiosciences Custom PCR Arrays for SRSF5
    Primer
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    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF5
    In Situ
    Assay Products:     
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    Orthologs
    for SRSF5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRSF5 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SRSF51 serine/arginine-rich splicing factor 5 82.95(n)
    97.35(a)    		   423258  NM_001031197.2  NP_001026368.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SRSF56
    		 --
    		 98(a)
    		 1 ↔ 1
    		 GL343318.1(700828-704651)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.54992 Xenopus laevis, Similar to splicing factor, arginine/serine-rich more 81.07(n)    BC044284.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.116952 Transcribed sequence with moderate similarity to protein more 76.2(n)    CK029459.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta B526
    		 B52
    		 46(a)
    		 1 → many
    		 3R(9487022-9492613)
    worm
    (Caenorhabditis elegans)    		 Secernentea rsp-16
    rsp-26
    (see all 3)    		 Probable splicing factor, arginine/serine-rich 2
    (see all 3)    		 40(a)
    38(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 II(11453914-11455743)
    II(11451380-11452891)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RS2Z336
    At-RS2Z6
    		 arginine/serine-rich zinc knuckle-containing prote...
    RNA recognition motif and CCHC-type zinc finger do...
    		 21(a)
    20(a)
    		 possible ortholog
    possible ortholog
    		 2(15670147-15672700)
    3(19834343-19837088)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 splicing factor, arginine/serine-rich, putative, e...
    splicing factor, arginine/serine-rich, putative, e...
    (see all 4)    		 17(a)
    16(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 1(2984356-2988299)
    3(9851647-9854979)


    ENSEMBL Gene Tree for SRSF5 (if available)
    TreeFam Gene Tree for SRSF5 (if available) 

    Paralogs
    for SRSF5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF5 gene
    LOC1009966572  SRSF42  SRSF122  SRSF102  SRSF92  SRSF22  SRSF72  SRSF12  
    SRSF62  SRSF32  
    18/37 SIMAP similar genes for SRSF5 using alignment to 5 protein entries:     SRSF5_HUMAN (see all proteins) (see all similar genes):
    SFRS5    SFRS6    SFRS4    SRSF4    SRSF6    SRSF9
    LOC440563    HNRNPC    SRSF1    LOC649330    RBM4    RBM4B
    RALY    RNPS1    SFRS3    SRSF3    A2BP1    DKFZp547L059

    SRSF5 for paralogs           About GeneDecksing



    Genomic Variants
    for SRSF5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/170 NCBI SNPs in SRSF5 are shown (see all 170)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1464119931,2
    		--70232197(+) ATAAAA/CATAGT 2 -- us2k10--------
    rs1390936851,2
    		--70232414(+) TTAACA/TCCCAC 2 -- us2k10--------
    rs1919434221,2
    		--70232427(+) TATAGA/GTAACT 2 -- us2k10--------
    rs1416565751,2
    		--70232577(+) CTACTG/TTTTCT 3 -- ds5001 us2k10--------
    rs775616221,2
    		--70232626(+) CAGGCA/CCTTCT 3 -- ds5001 us2k13Minor allele frequency- C:0.05CSA WA NA 240
    rs1844545261,2
    		--70232646(+) GGTGCA/GCTGGG 3 -- ds5001 us2k10--------
    rs756390861,2
    		--70232763(+) TTTTAC/TACCCA 3 -- ds5001 us2k11Minor allele frequency- T:0.01EA 120
    rs776830621,2
    		C,F,--70232767(+) ACACCC/TACTTT 3 -- us2k1 ds50011Minor allele frequency- T:0.02WA 118
    rs740614191,2
    		C,--70232832(+) ACAGAG/AATCTG 3 -- us2k1 ds50011Minor allele frequency- A:0.50WA 2
    rs1931694381,2
    		--70232892(+) CCGGGC/TGCGGT 3 -- us2k1 ds50010--------

    HapMap Linkage Disequilibrium report for SRSF5 (70193617 - 70238722 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SRSF5: --

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    Disorders / Diseases
    for SRSF5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRSF5 for disorders           About GeneDecksing

    OMIM gene information: 600914    OMIM disorders: --

    9 diseases for SRSF5:    About MalaCards
    open-angle glaucoma    pyruvate decarboxylase deficiency    primary open angle glaucoma    glaucoma
    bipolar disorder    scleroderma    breast cancer    immunodeficiency
    malaria

    1 disease from the University of Copenhagen DISEASES database for SRSF5:
    Pyruvate decarboxylase deficiency
    Human Genome Epidemiology (HuGE) Navigator: SRSF5 (0 documents)

    Export disorders for SRSF5 gene to outside databases

    Publications
    for SRSF5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF5 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with SRSF5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. (PubMed id 9434190)1, 2, 9 Du K. and Taub R. (1997)
    2. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PubMed id 7556075)1, 2, 9 Screaton G.R.... Krainer A.R. (1995)
    3. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A coactivator of pre-mRNA splicing. (PubMed id 9531537)1, 2 Blencowe B.J.... Sharp P.A. (1998)
    8. Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing. (PubMed id 7686911)1, 3 Diamond R.H....Taub R. (1993)
    9. SR proteins: a conserved family of pre-mRNA splicing factors. (PubMed id 1577277)1, 2 Zahler A.M.... Roth M.B. (1992)
    10. The switch in alternative splicing of cyclic AMP-response element modulator protein CREM{tau}2{alpha} (activator) to CREM{alpha} (repressor) in human myometrial cells is mediated by SRp40. (PubMed id 16103121)1, 9 Tyson-Capper A.J....Europe-Finner G.N. (2005)

    External Searches for SRSF5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SRSF5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6430 HGNC: 10787 AceView: SFRS5 Ensembl:ENSG00000100650 euGenes: HUgn6430
    ECgene: SRSF5 Kegg: 6430 H-InvDB: SRSF5

    Other Databases showing SRSF5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SRSF5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRSF5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SRSF5 gene:
    Search GeneIP for patents involving SRSF5

    GeneCards and IP:
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