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Aliases for SRSF5 Gene

Aliases for SRSF5 Gene

  • Serine/Arginine-Rich Splicing Factor 5 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 5 2 3 4
  • Pre-MRNA-Splicing Factor SRP40 3 4
  • Delayed-Early Protein HRS 3 4
  • SR Splicing Factor 5 2 3
  • SFRS5 3 4
  • SRP40 3 4
  • HRS 3 4

External Ids for SRSF5 Gene

Previous HGNC Symbols for SRSF5 Gene

  • SFRS5

Previous GeneCards Identifiers for SRSF5 Gene

  • GC14P070234
  • GC14P050402

Summaries for SRSF5 Gene

Entrez Gene Summary for SRSF5 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SRSF5 Gene

SRSF5 (Serine/Arginine-Rich Splicing Factor 5) is a Protein Coding gene. Diseases associated with SRSF5 include pyruvate dehydrogenase e1-alpha deficiency. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF4.

UniProtKB/Swiss-Prot for SRSF5 Gene

  • Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Gene Wiki entry for SRSF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF5 Gene

Genomics for SRSF5 Gene

Regulatory Elements for SRSF5 Gene

Promoters for SRSF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRSF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRSF5 Gene

Chromosome:
14
Start:
69,726,900 bp from pter
End:
69,772,005 bp from pter
Size:
45,106 bases
Orientation:
Plus strand

Genomic View for SRSF5 Gene

Genes around SRSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF5 Gene

Proteins for SRSF5 Gene

  • Protein details for SRSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13243-SRSF5_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 5
    Protein Accession:
    Q13243
    Secondary Accessions:
    • O14797
    • Q16662
    • Q49AD6
    • Q6FGE0

    Protein attributes for SRSF5 Gene

    Size:
    272 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.
    SequenceCaution:
    • Sequence=AAC39543.1; Type=Frameshift; Positions=113, 140; Evidence={ECO:0000305};

    Alternative splice isoforms for SRSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF5 Gene

Proteomics data for SRSF5 Gene at MOPED

Post-translational modifications for SRSF5 Gene

  • Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SRSF5 Gene

Domains & Families for SRSF5 Gene

Protein Domains for SRSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13243

UniProtKB/Swiss-Prot:

SRSF5_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF5: view

Function for SRSF5 Gene

Molecular function for SRSF5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Phenotypes for SRSF5 Gene

genes like me logo Genes that share phenotypes with SRSF5: view

Animal Model Products

CRISPR Products

miRNA for SRSF5 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF5 Gene

Localization for SRSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF5 Gene COMPARTMENTS Subcellular localization image for SRSF5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0016607 nuclear speck ISS --
genes like me logo Genes that share ontologies with SRSF5: view

Pathways & Interactions for SRSF5 Gene

genes like me logo Genes that share pathways with SRSF5: view

Gene Ontology (GO) - Biological Process for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006376 mRNA splice site selection TAS 7556075
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF5: view

No data available for SIGNOR curated interactions for SRSF5 Gene

Drugs & Compounds for SRSF5 Gene

(2) Drugs for SRSF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SRSF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRSF5: view

Transcripts for SRSF5 Gene

Unigene Clusters for SRSF5 Gene

Serine/arginine-rich splicing factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - -
SP17: - - - -
SP18: - - - -
SP19: - - - -
SP20: - - -
SP21:
SP22: - - -
SP23: -
SP24:
SP25:

ExUns: 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for SRSF5 Gene

GeneLoc Exon Structure for
SRSF5
ECgene alternative splicing isoforms for
SRSF5

Expression for SRSF5 Gene

mRNA expression in normal human tissues for SRSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF5 Gene

This gene is overexpressed in Adrenal (15.1), Peripheral blood mononuclear cells (8.4), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF5 Gene



SOURCE GeneReport for Unigene cluster for SRSF5 Gene Hs.632326

genes like me logo Genes that share expression patterns with SRSF5: view

Protein tissue co-expression partners for SRSF5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRSF5 Gene

Orthologs for SRSF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF5 35
  • 100 (n)
  • 100 (a)
SRSF5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF5 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRSF5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf5 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF5 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF5 35
  • 81.46 (n)
  • 94.94 (a)
SRSF5 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF5 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8018 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5499 35
zebrafish
(Danio rerio)
Actinopterygii Dr.11695 35
srsf5b 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8311 35
fruit fly
(Drosophila melanogaster)
Insecta B52 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsp-5 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToMany
CSA.9965 36
  • 53 (a)
OneToMany
Species with no ortholog for SRSF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF5 Gene

ENSEMBL:
Gene Tree for SRSF5 (if available)
TreeFam:
Gene Tree for SRSF5 (if available)

Paralogs for SRSF5 Gene

Paralogs for SRSF5 Gene

genes like me logo Genes that share paralogs with SRSF5: view

Variants for SRSF5 Gene

Sequence variations from dbSNP and Humsavar for SRSF5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1057683 - 69,771,032(+) AGAAT(G/T)CTATT nc-transcript-variant, reference, missense
rs2148504 -- 69,770,525(+) CCGAC(C/T)TAAAT nc-transcript-variant, reference, missense
rs1802832 -- 69,771,860(+) GGACA(C/T)TTAAA nc-transcript-variant, utr-variant-3-prime
rs3208848 -- 69,771,542(+) AAATT(C/T)TGGTA nc-transcript-variant, utr-variant-3-prime
rs3208849 -- 69,771,613(+) TTGTA(A/G)ATGTG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SRSF5 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV Gain 19166990

Variation tolerance for SRSF5 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF5 Gene

HapMap Linkage Disequilibrium report
SRSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF5 Gene

Disorders for SRSF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRSF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pyruvate dehydrogenase e1-alpha deficiency
  • pyruvate decarboxylase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search SRSF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRSF5

Human Genome Epidemiology (HuGE) Navigator
SRSF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF5
genes like me logo Genes that share disorders with SRSF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF5 Gene

Publications for SRSF5 Gene

  1. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. (PMID: 9434190) Du K. … Taub R. (Gene 1997) 3 4 23 67
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3
  3. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. (PMID: 19843576) Chandradas S. … Bogdanov V.Y. (J. Leukoc. Biol. 2010) 3 23
  4. Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity. (PMID: 19004959) Jablonski J.A. … Caputi M. (J. Virol. 2009) 3 23
  5. Biochemical and NMR study on the competition between proteins SC35, SRp40, and heterogeneous nuclear ribonucleoprotein A1 at the HIV-1 Tat exon 2 splicing site. (PMID: 16990281) Hallay H. … Branlant C. (J. Biol. Chem. 2006) 3 23

Products for SRSF5 Gene

Sources for SRSF5 Gene

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