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Aliases for SRSF5 Gene

Aliases for SRSF5 Gene

  • Serine And Arginine Rich Splicing Factor 5 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 5 2 3 4
  • Serine/Arginine-Rich Splicing Factor 5 2 3
  • Pre-MRNA-Splicing Factor SRP40 3 4
  • Delayed-Early Protein HRS 3 4
  • SR Splicing Factor 5 2 3
  • SFRS5 3 4
  • SRP40 3 4
  • HRS 3 4

External Ids for SRSF5 Gene

Previous HGNC Symbols for SRSF5 Gene

  • SFRS5

Previous GeneCards Identifiers for SRSF5 Gene

  • GC14P070234
  • GC14P050402

Summaries for SRSF5 Gene

Entrez Gene Summary for SRSF5 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SRSF5 Gene

SRSF5 (Serine And Arginine Rich Splicing Factor 5) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Influenza A. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF6.

UniProtKB/Swiss-Prot for SRSF5 Gene

  • Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Gene Wiki entry for SRSF5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF5 Gene

Genomics for SRSF5 Gene

Regulatory Elements for SRSF5 Gene

Enhancers for SRSF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G069692 2 FANTOM5 Ensembl ENCODE dbSUPER 19.5 -28.8 -28776 12.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B DMAP1 SLC30A9 ZNF766 KLF13 SUSD6 SRSF5 HMGN1P3 ACTN1 TTC9 SLC8A3 PIR54293 GC14P069678
GH14G069609 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.8 -110.9 -110920 12.2 HDGF FOXA2 ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 FOS DEK SRSF5 SUSD6 SMOC1 DCAF5 ENSG00000273797
GH14G069642 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.8 -82.9 -82944 3.4 PKNOX1 FOXA2 CREB3L1 BRCA1 YY1 CBX5 ZNF143 FOS ZHX2 KAT8 SUSD6 SRSF5 DCAF5 GC14P069648 GC14M069622
GH14G069682 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.8 -42.4 -42367 5.1 PKNOX1 FOXA2 ARID4B RAD21 GATA2 FOS CREM JUNB REST SMARCA4 SUSD6 SRSF5 SMOC1 GC14P069678 PIR54293
GH14G069634 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.9 -89.4 -89356 6.1 HDGF PKNOX1 MLX WRNIP1 ARID4B ZNF48 YY1 TCF12 SP5 MXD4 SUSD6 SRSF5 DCAF5 GC14M069622 GC14P069648
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRSF5 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000070265 200 601 WRNIP1 ARID4B ZNF48 ZNF143 ZNF207 DEK REST ZNF592 KAT8 ZNF579

Genomic Location for SRSF5 Gene

Chromosome:
14
Start:
69,726,900 bp from pter
End:
69,772,005 bp from pter
Size:
45,106 bases
Orientation:
Plus strand

Genomic View for SRSF5 Gene

Genes around SRSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF5 Gene

Proteins for SRSF5 Gene

  • Protein details for SRSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13243-SRSF5_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 5
    Protein Accession:
    Q13243
    Secondary Accessions:
    • O14797
    • Q16662
    • Q49AD6
    • Q6FGE0

    Protein attributes for SRSF5 Gene

    Size:
    272 amino acids
    Molecular mass:
    31264 Da
    Quaternary structure:
    • Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.
    SequenceCaution:
    • Sequence=AAC39543.1; Type=Frameshift; Positions=113, 140; Evidence={ECO:0000305};

    Alternative splice isoforms for SRSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF5 Gene

Post-translational modifications for SRSF5 Gene

  • Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at isoforms=3125
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRSF5 Gene

Domains & Families for SRSF5 Gene

Protein Domains for SRSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13243

UniProtKB/Swiss-Prot:

SRSF5_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF5: view

Function for SRSF5 Gene

Molecular function for SRSF5 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Gene Ontology (GO) - Molecular Function for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 12762840
GO:0043422 protein kinase B binding IEA --
GO:0050733 RS domain binding IEA --
genes like me logo Genes that share ontologies with SRSF5: view

Phenotypes for SRSF5 Gene

genes like me logo Genes that share phenotypes with SRSF5: view

Animal Model Products

CRISPR Products

miRNA for SRSF5 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF5 Gene

Localization for SRSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF5 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
GO:0016607 nuclear speck ISS --
genes like me logo Genes that share ontologies with SRSF5: view

Pathways & Interactions for SRSF5 Gene

genes like me logo Genes that share pathways with SRSF5: view

Pathways by source for SRSF5 Gene

Gene Ontology (GO) - Biological Process for SRSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001889 liver development IEA --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006376 mRNA splice site selection TAS 7556075
GO:0006397 mRNA processing TAS 7556075
genes like me logo Genes that share ontologies with SRSF5: view

No data available for SIGNOR curated interactions for SRSF5 Gene

Drugs & Compounds for SRSF5 Gene

(2) Drugs for SRSF5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SRSF5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SRSF5: view

Transcripts for SRSF5 Gene

Unigene Clusters for SRSF5 Gene

Serine/arginine-rich splicing factor 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g ^ 6a · 6b · 6c · 6d ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - -
SP12: - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - - -
SP16: - - -
SP17: - - - -
SP18: - - - -
SP19: - - - -
SP20: - - -
SP21:
SP22: - - -
SP23: -
SP24:
SP25:

ExUns: 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21: -
SP22:
SP23:
SP24:
SP25:

Relevant External Links for SRSF5 Gene

GeneLoc Exon Structure for
SRSF5
ECgene alternative splicing isoforms for
SRSF5

Expression for SRSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF5 Gene

This gene is overexpressed in Adrenal (15.1), Peripheral blood mononuclear cells (8.4), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF5 Gene



Protein tissue co-expression partners for SRSF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF5 Gene:

SRSF5

SOURCE GeneReport for Unigene cluster for SRSF5 Gene:

Hs.632326

Evidence on tissue expression from TISSUES for SRSF5 Gene

  • Liver(4.8)
  • Nervous system(4.8)
  • Skin(4.7)
  • Intestine(4.5)
  • Eye(3.1)
  • Lung(2.9)
  • Pancreas(2.9)
  • Bone marrow(2.5)
  • Kidney(2.4)
  • Lymph node(2.4)
  • Muscle(2.4)
  • Spleen(2.4)
  • Adrenal gland(2.3)
  • Blood(2.3)
  • Gall bladder(2.3)
  • Thyroid gland(2.3)
  • Heart(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with SRSF5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF5 Gene

Orthologs for SRSF5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF5 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia SFRS5 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF5 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRSF5 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf5 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF5 35
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF5 34 35
  • 81.46 (n)
lizard
(Anolis carolinensis)
Reptilia SRSF5 35
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8018 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.5499 34
zebrafish
(Danio rerio)
Actinopterygii srsf5b 35
  • 70 (a)
OneToOne
Dr.11695 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8311 34
fruit fly
(Drosophila melanogaster)
Insecta B52 35
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsp-5 35
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
CSA.9965 35
  • 53 (a)
OneToMany
Species where no ortholog for SRSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF5 Gene

ENSEMBL:
Gene Tree for SRSF5 (if available)
TreeFam:
Gene Tree for SRSF5 (if available)

Paralogs for SRSF5 Gene

Variants for SRSF5 Gene

Sequence variations from dbSNP and Humsavar for SRSF5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000041250 -- 69,771,646(+) ACTAA(C/T)TGTAT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000320344 -- 69,767,144(+) TGCGT(C/T)AGTTG nc-transcript-variant, utr-variant-5-prime
rs1000487319 -- 69,770,275(+) AAGCA(A/G)TATGC intron-variant, nc-transcript-variant
rs1001042489 -- 69,770,590(+) TTTTA(C/T)TGTGA intron-variant
rs1001300670 -- 69,767,733(+) CGAGG(C/T)GTCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRSF5 Gene

Variant ID Type Subtype PubMed ID
nsv456336 CNV gain 19166990
nsv565007 CNV gain 21841781

Variation tolerance for SRSF5 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF5 Gene

Disorders for SRSF5 Gene

Relevant External Links for SRSF5

Human Genome Epidemiology (HuGE) Navigator
SRSF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF5

No disorders were found for SRSF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF5 Gene

Publications for SRSF5 Gene

  1. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. (PMID: 9434190) Du K. … Taub R. (Gene 1997) 3 4 22 64
  2. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. (PMID: 7556075) Screaton G.R. … Krainer A.R. (EMBO J. 1995) 3 4 22 64
  3. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3 64
  4. Antagonistic roles of four SR proteins in the biosynthesis of alternatively spliced tissue factor transcripts in monocytic cells. (PMID: 19843576) Chandradas S. … Bogdanov V.Y. (J. Leukoc. Biol. 2010) 3 22 64
  5. Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity. (PMID: 19004959) Jablonski J.A. … Caputi M. (J. Virol. 2009) 3 22 64

Products for SRSF5 Gene

Sources for SRSF5 Gene

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