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Aliases for SRSF4 Gene

Aliases for SRSF4 Gene

  • Serine/Arginine-Rich Splicing Factor 4 2 3
  • Splicing Factor, Arginine/Serine-Rich 4 2 3 4
  • SFRS4 3 4 6
  • SRP75 3 4 6
  • Pre-MRNA-Splicing Factor SRP75 3 4
  • SR Splicing Factor 4 2 3
  • SRP001LB 3 4

External Ids for SRSF4 Gene

Previous HGNC Symbols for SRSF4 Gene

  • SFRS4

Previous GeneCards Identifiers for SRSF4 Gene

  • GC01M029474
  • GC01M027727

Summaries for SRSF4 Gene

Entrez Gene Summary for SRSF4 Gene

  • This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

GeneCards Summary for SRSF4 Gene

SRSF4 (Serine/Arginine-Rich Splicing Factor 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF3.

UniProtKB/Swiss-Prot for SRSF4 Gene

  • Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for SRSF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF4 Gene

Genomics for SRSF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRSF4 Gene

29,147,738 bp from pter
29,182,125 bp from pter
34,388 bases
Minus strand

Genomic View for SRSF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF4 Gene

No data available for Regulatory Elements for SRSF4 Gene

Proteins for SRSF4 Gene

  • Protein details for SRSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/arginine-rich splicing factor 4
    Protein Accession:
    Secondary Accessions:
    • Q5VXP1
    • Q9BUA4
    • Q9UEB5

    Protein attributes for SRSF4 Gene

    494 amino acids
    Molecular mass:
    56678 Da
    Quaternary structure:
    • Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN.

neXtProt entry for SRSF4 Gene

Proteomics data for SRSF4 Gene at MOPED

Post-translational modifications for SRSF4 Gene

Other Protein References for SRSF4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRSF4 Gene

Domains for SRSF4 Gene

Gene Families for SRSF4 Gene

  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF4 Gene

Suggested Antigen Peptide Sequences for SRSF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q08170
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF4: view

Function for SRSF4 Gene

Molecular function for SRSF4 Gene

UniProtKB/Swiss-Prot Function: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF4: view
genes like me logo Genes that share phenotypes with SRSF4: view

Animal Model Products

CRISPR Products

miRNA for SRSF4 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRSF4 Gene

Localization for SRSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF4 Gene

Nucleus speckle.

Subcellular locations from

Jensen Localization Image for SRSF4 Gene COMPARTMENTS Subcellular localization image for SRSF4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8321209
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with SRSF4: view

Pathways for SRSF4 Gene

genes like me logo Genes that share pathways with SRSF4: view

Gene Ontology (GO) - Biological Process for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 8321209
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
genes like me logo Genes that share ontologies with SRSF4: view

Transcripts for SRSF4 Gene

Unigene Clusters for SRSF4 Gene

Serine/arginine-rich splicing factor 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: -
SP6: - - - -
SP7: - - -
SP8: - - - - - - - - - -
SP10: - - - -

Relevant External Links for SRSF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRSF4 Gene

mRNA expression in normal human tissues for SRSF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF4 Gene

SOURCE GeneReport for Unigene cluster for SRSF4 Gene Hs.469970

genes like me logo Genes that share expressions with SRSF4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRSF4 Gene

Orthologs for SRSF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRSF4 35
  • 99.87 (n)
  • 99.8 (a)
SRSF4 36
  • 100 (a)
(Bos Taurus)
Mammalia SFRS4 36
  • 93 (a)
SRSF4 35
  • 88.84 (n)
  • 92.63 (a)
(Canis familiaris)
Mammalia SRSF4 35
  • 88.41 (n)
  • 92.03 (a)
SRSF4 36
  • 89 (a)
(Mus musculus)
Mammalia Srsf4 35
  • 83.52 (n)
  • 84.92 (a)
Srsf4 16
Srsf4 36
  • 90 (a)
(Monodelphis domestica)
Mammalia SRSF4 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia SRSF4 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Srsf4 35
  • 84.86 (n)
  • 87.02 (a)
(Gallus gallus)
Aves SRSF4 35
  • 73.71 (n)
  • 83.67 (a)
SRSF4 36
  • 74 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
(Danio rerio)
Actinopterygii srsf4 36
  • 68 (a)
wufb37e02 35
(Caenorhabditis elegans)
Secernentea rsp-2 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 36
  • 18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9457 35
Species with no ortholog for SRSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRSF4 Gene

Gene Tree for SRSF4 (if available)
Gene Tree for SRSF4 (if available)

Paralogs for SRSF4 Gene

Paralogs for SRSF4 Gene

Selected SIMAP similar genes for SRSF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRSF4: view

Variants for SRSF4 Gene

Sequence variations from dbSNP and Humsavar for SRSF4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs401485 -- 29,153,792(-) acccc(A/G)tctct intron-variant
rs403807 -- 29,175,552(-) gctcc(C/T)ggcta intron-variant
rs408532 -- 29,160,138(-) TGTGT(G/T)TGTGT intron-variant, utr-variant-5-prime
rs408543 -- 29,160,127(-) TGTTG(G/T)TGTTT intron-variant, utr-variant-5-prime
rs471895 -- 29,161,778(-) CTACT(A/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF4 Gene

Variant ID Type Subtype PubMed ID
nsv509091 CNV Insertion 20534489

Relevant External Links for SRSF4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF4 Gene

Disorders for SRSF4 Gene

No disorders were found for SRSF4 Gene.

No data available for UniProtKB/Swiss-Prot for SRSF4 Gene

Publications for SRSF4 Gene

  1. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PMID: 14578391) Zimowska G. … Sugrue S.P. (Invest. Ophthalmol. Vis. Sci. 2003) 3 4 23
  2. Human SR proteins and isolation of a cDNA encoding SRp75. (PMID: 8321209) Zahler A.M. … Roth M.B. (Mol. Cell. Biol. 1993) 2 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. SR proteins: a conserved family of pre-mRNA splicing factors. (PMID: 1577277) Zahler A.M. … Roth M.B. (Genes Dev. 1992) 3 4

Products for SRSF4 Gene

Sources for SRSF4 Gene

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