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Aliases for SRSF4 Gene

Aliases for SRSF4 Gene

  • Serine And Arginine Rich Splicing Factor 4 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 4 2 3 4
  • Serine/Arginine-Rich Splicing Factor 4 2 3
  • Pre-MRNA-Splicing Factor SRP75 3 4
  • SR Splicing Factor 4 2 3
  • SRP001LB 3 4
  • SFRS4 3 4
  • SRP75 3 4

External Ids for SRSF4 Gene

Previous HGNC Symbols for SRSF4 Gene

  • SFRS4

Previous GeneCards Identifiers for SRSF4 Gene

  • GC01M029474
  • GC01M027727

Summaries for SRSF4 Gene

Entrez Gene Summary for SRSF4 Gene

  • This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

GeneCards Summary for SRSF4 Gene

SRSF4 (Serine And Arginine Rich Splicing Factor 4) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF6.

UniProtKB/Swiss-Prot for SRSF4 Gene

  • Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for SRSF4 Gene

Additional gene information for SRSF4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF4 Gene

Genomics for SRSF4 Gene

Regulatory Elements for SRSF4 Gene

Enhancers for SRSF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H028881 2 FANTOM5 Ensembl ENCODE dbSUPER 138.9 +296.9 296883 6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 SRSF4 TRNAU1AP GMEB1 SNHG12 YTHDF2 TMEM200B PHACTR4 RCC1 EYA3 ENSG00000237934
GH01H028647 1.2 ENCODE 126.1 +533.7 533680 2 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A ZFP41 GMEB1 SRSF4 YTHDF2 TRNAU1AP FAM76A SNHG12 PHACTR4 EYA3 RCC1 PPP1R8
GH01H029236 1.4 FANTOM5 ENCODE 91.8 -56.6 -56590 5 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 DEK SRSF4 TRNAU1AP GMEB1 YTHDF2 SNHG12 PHACTR4 TMEM200B RCC1 ENSG00000237934 SNORA73B
GH01H028579 1.2 ENCODE 96.6 +600.9 600925 4 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN GMEB1 SRSF4 TRNAU1AP FAM76A SNHG12 YTHDF2 PHACTR4 SNORA73B RCC1 ENSG00000231344
GH01H028258 1.4 ENCODE dbSUPER 63.3 +922.2 922157 3 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF416 ZNF143 FOS SRSF4 TRNAU1AP GMEB1 SNHG12 YTHDF2 FAM76A PHACTR4 DNAJC8 ACTG1P20 ENSG00000270605
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRSF4 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003944 825 2601 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 ZC3H11A PPARGC1A MEF2D ZNF610

Genomic Location for SRSF4 Gene

Chromosome:
1
Start:
29,147,738 bp from pter
End:
29,182,125 bp from pter
Size:
34,388 bases
Orientation:
Minus strand

Genomic View for SRSF4 Gene

Genes around SRSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF4 Gene

Proteins for SRSF4 Gene

  • Protein details for SRSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08170-SRSF4_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 4
    Protein Accession:
    Q08170
    Secondary Accessions:
    • Q5VXP1
    • Q9BUA4
    • Q9UEB5

    Protein attributes for SRSF4 Gene

    Size:
    494 amino acids
    Molecular mass:
    56678 Da
    Quaternary structure:
    • Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN.

neXtProt entry for SRSF4 Gene

Post-translational modifications for SRSF4 Gene

Other Protein References for SRSF4 Gene

No data available for DME Specific Peptides for SRSF4 Gene

Domains & Families for SRSF4 Gene

Gene Families for SRSF4 Gene

Protein Domains for SRSF4 Gene

Graphical View of Domain Structure for InterPro Entry

Q08170

UniProtKB/Swiss-Prot:

SRSF4_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF4: view

Function for SRSF4 Gene

Molecular function for SRSF4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 17353931
GO:1990825 sequence-specific mRNA binding IEA --
genes like me logo Genes that share ontologies with SRSF4: view
genes like me logo Genes that share phenotypes with SRSF4: view

Animal Models for SRSF4 Gene

MGI Knock Outs for SRSF4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF4 Gene

Localization for SRSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF4 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF4 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 8321209
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with SRSF4: view

Pathways & Interactions for SRSF4 Gene

genes like me logo Genes that share pathways with SRSF4: view

Pathways by source for SRSF4 Gene

Gene Ontology (GO) - Biological Process for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 8321209
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing TAS 8321209
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF4: view

No data available for SIGNOR curated interactions for SRSF4 Gene

Drugs & Compounds for SRSF4 Gene

No Compound Related Data Available

Transcripts for SRSF4 Gene

Unigene Clusters for SRSF4 Gene

Serine/arginine-rich splicing factor 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: -
SP5:
SP6: - - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - -

Relevant External Links for SRSF4 Gene

GeneLoc Exon Structure for
SRSF4
ECgene alternative splicing isoforms for
SRSF4

Expression for SRSF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF4 Gene

This gene is overexpressed in Nasal epithelium (18.8) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF4 Gene



Protein tissue co-expression partners for SRSF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF4 Gene:

SRSF4

SOURCE GeneReport for Unigene cluster for SRSF4 Gene:

Hs.469970

Evidence on tissue expression from TISSUES for SRSF4 Gene

  • Liver(4.4)
  • Nervous system(3.8)
  • Lung(2.1)
  • Spleen(2.1)
  • Heart(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SRSF4: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF4 Gene

Orthologs for SRSF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF4 34 33
  • 99.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS4 34
  • 93 (a)
OneToOne
SRSF4 33
  • 88.84 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF4 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF4 34 33
  • 88.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf4 33
  • 84.86 (n)
mouse
(Mus musculus)
Mammalia Srsf4 34 16 33
  • 83.52 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF4 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF4 33 34
  • 73.71 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 61 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii srsf4 34
  • 68 (a)
OneToOne
wufb37e02 33
worm
(Caenorhabditis elegans)
Secernentea rsp-2 34
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 34
  • 18 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9457 33
Species where no ortholog for SRSF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRSF4 Gene

ENSEMBL:
Gene Tree for SRSF4 (if available)
TreeFam:
Gene Tree for SRSF4 (if available)

Paralogs for SRSF4 Gene

Paralogs for SRSF4 Gene

(10) SIMAP similar genes for SRSF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRSF4: view

Variants for SRSF4 Gene

Sequence variations from dbSNP and Humsavar for SRSF4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000055520 -- 29,151,169(+) AAAGC(C/T)GCCCA intron-variant
rs1000113300 -- 29,153,010(+) CATGT(C/T)CTTAG intron-variant
rs1000194742 -- 29,180,675(+) CTTTT(A/G)ATTTT intron-variant
rs1000220318 -- 29,182,416(+) GTGCC(C/T)AATAA upstream-variant-2KB
rs1000220986 -- 29,180,913(+) GGGTG(A/G)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF4 Gene

Variant ID Type Subtype PubMed ID
esv3585602 CNV gain 21293372
nsv509091 CNV insertion 20534489

Variation tolerance for SRSF4 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.22; 97.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF4 Gene

Disorders for SRSF4 Gene

Relevant External Links for SRSF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF4

No disorders were found for SRSF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF4 Gene

Publications for SRSF4 Gene

  1. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PMID: 14578391) Zimowska G … Sugrue SP (Investigative ophthalmology & visual science 2003) 3 4 22 60
  2. Human SR proteins and isolation of a cDNA encoding SRp75. (PMID: 8321209) Zahler AM … Roth MB (Molecular and cellular biology 1993) 2 3 4 60
  3. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 60
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60

Products for SRSF4 Gene

Sources for SRSF4 Gene

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