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Aliases for SRSF4 Gene

Aliases for SRSF4 Gene

  • Serine/Arginine-Rich Splicing Factor 4 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 4 2 3 4
  • Pre-MRNA-Splicing Factor SRP75 3 4
  • SR Splicing Factor 4 2 3
  • SRP001LB 3 4
  • SFRS4 3 4
  • SRP75 3 4

External Ids for SRSF4 Gene

Previous HGNC Symbols for SRSF4 Gene

  • SFRS4

Previous GeneCards Identifiers for SRSF4 Gene

  • GC01M029474
  • GC01M027727

Summaries for SRSF4 Gene

Entrez Gene Summary for SRSF4 Gene

  • This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

GeneCards Summary for SRSF4 Gene

SRSF4 (Serine/Arginine-Rich Splicing Factor 4) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SRSF3.

UniProtKB/Swiss-Prot for SRSF4 Gene

  • Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Gene Wiki entry for SRSF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF4 Gene

Genomics for SRSF4 Gene

Regulatory Elements for SRSF4 Gene

Promoters for SRSF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRSF4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRSF4 Gene

Chromosome:
1
Start:
29,147,738 bp from pter
End:
29,182,125 bp from pter
Size:
34,388 bases
Orientation:
Minus strand

Genomic View for SRSF4 Gene

Genes around SRSF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF4 Gene

Proteins for SRSF4 Gene

  • Protein details for SRSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08170-SRSF4_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 4
    Protein Accession:
    Q08170
    Secondary Accessions:
    • Q5VXP1
    • Q9BUA4
    • Q9UEB5

    Protein attributes for SRSF4 Gene

    Size:
    494 amino acids
    Molecular mass:
    56678 Da
    Quaternary structure:
    • Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN.

neXtProt entry for SRSF4 Gene

Proteomics data for SRSF4 Gene at MOPED

Post-translational modifications for SRSF4 Gene

Other Protein References for SRSF4 Gene

No data available for DME Specific Peptides for SRSF4 Gene

Domains & Families for SRSF4 Gene

Protein Domains for SRSF4 Gene

Graphical View of Domain Structure for InterPro Entry

Q08170

UniProtKB/Swiss-Prot:

SRSF4_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF4: view

Function for SRSF4 Gene

Molecular function for SRSF4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Gene Ontology (GO) - Molecular Function for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SRSF4: view
genes like me logo Genes that share phenotypes with SRSF4: view

Animal Models for SRSF4 Gene

MGI Knock Outs for SRSF4:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF4 Gene

Localization for SRSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF4 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF4 Gene COMPARTMENTS Subcellular localization image for SRSF4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SRSF4: view

Pathways & Interactions for SRSF4 Gene

genes like me logo Genes that share pathways with SRSF4: view

Gene Ontology (GO) - Biological Process for SRSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 8321209
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF4: view

No data available for SIGNOR curated interactions for SRSF4 Gene

Drugs & Compounds for SRSF4 Gene

No Compound Related Data Available

Transcripts for SRSF4 Gene

Unigene Clusters for SRSF4 Gene

Serine/arginine-rich splicing factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: -
SP5:
SP6: - - - -
SP7: - - -
SP8: - - - - - - - - - -
SP9:
SP10: - - - -

Relevant External Links for SRSF4 Gene

GeneLoc Exon Structure for
SRSF4
ECgene alternative splicing isoforms for
SRSF4

Expression for SRSF4 Gene

mRNA expression in normal human tissues for SRSF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF4 Gene

This gene is overexpressed in Nasal epithelium (18.8) and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF4 Gene



SOURCE GeneReport for Unigene cluster for SRSF4 Gene Hs.469970

genes like me logo Genes that share expression patterns with SRSF4: view

Protein tissue co-expression partners for SRSF4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRSF4 Gene

Orthologs for SRSF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SRSF4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRSF4 35
  • 88.84 (n)
  • 92.63 (a)
SFRS4 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF4 35
  • 88.41 (n)
  • 92.03 (a)
SRSF4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf4 35
  • 83.52 (n)
  • 84.92 (a)
Srsf4 16
Srsf4 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRSF4 35
  • 99.87 (n)
  • 99.8 (a)
SRSF4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf4 35
  • 84.86 (n)
  • 87.02 (a)
oppossum
(Monodelphis domestica)
Mammalia SRSF4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF4 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF4 35
  • 73.71 (n)
  • 83.67 (a)
SRSF4 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 61 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii wufb37e02 35
srsf4 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsp-2 36
  • 48 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NPL3 36
  • 18 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9457 35
Species with no ortholog for SRSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRSF4 Gene

ENSEMBL:
Gene Tree for SRSF4 (if available)
TreeFam:
Gene Tree for SRSF4 (if available)

Paralogs for SRSF4 Gene

Paralogs for SRSF4 Gene

(10) SIMAP similar genes for SRSF4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRSF4: view

Variants for SRSF4 Gene

Sequence variations from dbSNP and Humsavar for SRSF4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2230679 - 29,149,136(-) AAGGA(A/C)AAGAG reference, missense
rs2230677 - 29,148,882(-) CAAAG(A/C/G/T)GGGCA reference, missense
rs2230678 - 29,148,829(-) GGAAG(A/G)GCAGG reference, missense
rs1049928 - 29,148,583(-) CCAAT(C/G)AGGAG reference, missense
rs401485 -- 29,153,792(-) acccc(A/G)tctct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF4 Gene

Variant ID Type Subtype PubMed ID
nsv509091 CNV Insertion 20534489

Variation tolerance for SRSF4 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.22; 97.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF4 Gene

HapMap Linkage Disequilibrium report
SRSF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF4 Gene

Disorders for SRSF4 Gene

Relevant External Links for SRSF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF4

No disorders were found for SRSF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF4 Gene

Publications for SRSF4 Gene

  1. Human SR proteins and isolation of a cDNA encoding SRp75. (PMID: 8321209) Zahler A.M. … Roth M.B. (Mol. Cell. Biol. 1993) 2 3 4 67
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3
  3. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PMID: 14578391) Zimowska G. … Sugrue S.P. (Invest. Ophthalmol. Vis. Sci. 2003) 3 23
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing. (PMID: 25263594) Guo R. … Shi Y. (Mol. Cell 2014) 3

Products for SRSF4 Gene

Sources for SRSF4 Gene

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