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SRSF4 Gene

protein-coding   GIFtS: 57
GCID: GC01M029474

Serine/Arginine-Rich Splicing Factor 4

(Previous names: splicing factor, arginine/serine-rich 4)
(Previous symbol: SFRS4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine-Rich Splicing Factor 41 2     Pre-MRNA-Splicing Factor SRP752 3
SFRS41 2 3 5     SRP001LB2 3
Splicing Factor, Arginine/Serine-Rich 41 2 3     SRP752 3
SR Splicing Factor 41 2     SRp755

External Ids:    HGNC: 107861   Entrez Gene: 64292   Ensembl: ENSG000001163507   OMIM: 6019405   UniProtKB: Q081703   

Export aliases for SRSF4 gene to outside databases

Previous GC identifer: GC01M027727


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRSF4 Gene:
This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely
functions in mRNA processing. (provided by RefSeq, Feb 2009)

GeneCards Summary for SRSF4 Gene:
SRSF4 (serine/arginine-rich splicing factor 4) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF4_HUMAN, Q08170
Function: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of
MAPT/Tau exon 10

Gene Wiki entry for SRSF4 (SFRS4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF4 promoter sequence
   Search Chromatin IP Primers for SRSF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.3

SRSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M029474:  view genomic region     (about GC identifiers)

Start:
29,474,250 bp from pter      End:
29,508,637 bp from pter
Size:
34,388 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRSF4_HUMAN, Q08170 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 4  
Size: 494 amino acids; 56678 Da
Subunit: Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2.
Interacts with PNN
Secondary accessions: Q5VXP1 Q9BUA4 Q9UEB5

Explore the universe of human proteins at neXtProt for SRSF4: NX_Q08170

Explore proteomics data for SRSF4 at MOPED

Post-translational modifications: 

  • Extensively phosphorylated on serine residues in the RS domain1
  • Ubiquitination2 at Lys27
  • Modification sites at PhosphoSitePlus

  • See SRSF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005617.2  
    ENSEMBL proteins: 
     ENSP00000362900   ENSP00000473728   ENSP00000444600  
    Reactome Protein details: Q08170

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q08170

    ProtoNet protein and cluster: Q08170

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF4_HUMAN, Q08170
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with SRSF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF4_HUMAN, Q08170
    Function: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of
    MAPT/Tau exon 10

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRSF4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SRSF4:
     Cell division defect  Increased G2M DNA content 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srsf4):
     behavior/neurological  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  other  vision/eye 

    Find genes that share phenotypes with SRSF4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRSF4
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    miRNA
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    miRTarBase miRNAs that target SRSF4:
    hsa-mir-1 (MIRT023667), hsa-mir-769-5p (MIRT039215), hsa-mir-1913 (MIRT035798), hsa-mir-877-3p (MIRT036942), hsa-mir-1180-3p (MIRT035954)

    Block miRNA regulation of human, mouse, rat SRSF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF4 (see all 10):
    hsa-miR-3163 hsa-miR-548p hsa-miR-607 hsa-miR-3688-3p hsa-miR-509-5p hsa-miR-483-5p hsa-miR-139-5p hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidSRSF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRSF4

    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRSF4_HUMAN, Q08170: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with SRSF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRSF4 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SRSF4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF4
        mRNA processing

    4 Reactome Pathways for SRSF4
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


    2 Kegg Pathways  (Kegg details for SRSF4):
        Spliceosome
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF4
    Interactions:

        Search GeneGlobe Interaction Network for SRSF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRSF4 (Q081702, 3 ENSP000003629004) via UniProtKB, MINT, STRING, and/or I2D (see all 777)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5205755 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    FUSP356372, 3, ENSP000002541084MINT-7947479 I2D: score=2 STRING: ENSP00000254108
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7947479 I2D: score=1 STRING: ENSP00000326261
    HAP1P542572, 3MINT-64068 I2D: score=4 
    RNPS1Q152872, 3, ENSP000003158594MINT-8337893 I2D: score=1 STRING: ENSP00000315859
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions TAS8321209
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS8321209

    Find genes that share ontologies with SRSF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRSF4 gene: 
    NM_005626.4  

    Unigene Cluster for SRSF4:

    Serine/arginine-rich splicing factor 4
    Hs.469970  [show with all ESTs]
    Unigene Representative Sequence: NM_005626
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373795(uc001bro.3 uc010ofy.2 uc009vtp.2) ENST00000466448
    ENST00000497015 ENST00000605204 ENST00000477193 ENST00000489898 ENST00000472353
    ENST00000546138
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRSF4 (see all 10):
    hsa-miR-3163 hsa-miR-548p hsa-miR-607 hsa-miR-3688-3p hsa-miR-509-5p hsa-miR-483-5p hsa-miR-139-5p hsa-miR-4261
    SwitchGear 3'UTR luciferase reporter plasmidSRSF4 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: SRSF4 (NM_005626)
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      QuantiTect SYBR Green Assays in human, mouse, rat SRSF4
      QuantiFast Probe-based Assays in human, mouse, rat SRSF4

    Additional mRNA sequence: 

    AB073890.1 AK223444.1 AK291509.1 AK293706.1 AK310528.1 BC002781.2 BT007415.1 L14076.1 

    21 DOTS entries:

    DT.91866269  DT.447026  DT.409564  DT.100796314  DT.101970353  DT.100796309  DT.121359887  DT.100796313 
    DT.91761381  DT.92070418  DT.121359879  DT.92059619  DT.121359873  DT.121359891  DT.121359892  DT.75161147 
    DT.92020068  DT.95321068  DT.97776365  DT.97820511  DT.99995282 

    Selected AceView cDNA sequences (see all 364):

    BX099566 NM_005626 CA430854 AI268317 BU687501 BI492812 BU741588 AW139146 
    CR595944 BF796441 BM128684 AI601153 BT007415 AA055897 BM972684 AA613388 
    AI371348 CR594929 AI423362 AI270224 BU607438 AI217083 AI921231 CA446139 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRSF4 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c
    SP1:        -     -     -     -     -                 -     -     -     -                       -                           
    SP2:              -     -     -     -                 -     -     -     -                       -                           
    SP3:              -     -     -     -                 -     -     -     -                       -     -                     
    SP4:                                                                                            -                           
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for SRSF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRSF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCACAGTA
    SRSF4 Expression
    About this image


    SRSF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Ovary (Reproductive System)
     
     Placenta (Extraembryonic Tissues)
     
     Uterus (Reproductive System)
    SRSF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469970
        Custom PCR Arrays for SRSF4
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SRSF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SRSF4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf41 , 5 serine/arginine-rich splicing factor 41, 5 83.52(n)1
    84.92(a)1
      4 (64.53 cM)5
    573171  NM_020587.21  NP_065612.21 
     1318736175 
    chicken
    (Gallus gallus)
    Aves SRSF41 serine/arginine-rich splicing factor 4 73.71(n)
    83.67(a)
      419600  XM_004947730.1  XP_004947787.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    61(a)
    many ↔ many
    GL343272.1(253620-281068)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb37e022 wufb37e02 78.36(n)   321872  BC046895.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-26
    Protein RSP-2 (rsp-2) mRNA, complete cds
    48(a)
    many ↔ many
    II(11451444-11452955) WBGene00004699
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NPL36
    RNA-binding protein that promotes elongation, regu...
    18(a)
    1 → many
    IV(1328783-1330027) YDR432W


    ENSEMBL Gene Tree for SRSF4 (if available)
    TreeFam Gene Tree for SRSF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRSF4 gene
    SRSF52  SRSF92  SRSF72  SRSF12  SRSF62  SRSF32  
    10 SIMAP similar genes for SRSF4 using alignment to 3 protein entries:     SRSF4_HUMAN (see all proteins):
    SFRS4    SFRS6    SRSF6    SFRS5    SRSF5    SRSF9
    RALY    SFRS3    SRSF1    IGF2BP3

    Find genes that share paralogs with SRSF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRSF4 (see all 735)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717792041,2
    C--27756333(+) AAGAT-/T/TT  
            
    TTTTT
    1 -- int10--------
    rs28196081,2
    C,F,H--29473838(-) ATCACA/C/GCATCT 1 -- ds500114NA WA CSA EA 507
    rs105941661,2
    C--29473893(+) ttttt-/T/TT/ 
     TTTTTTT
    gagac
    1 -- ds50011NA 2
    rs1137845031,2
    C--29473899(+) TGAGAC/TGGAGT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs24527821,2
    C,A,H--29474134(-) GTTTGG/TGAGGC 1 -- ds500112Minor allele frequency- T:0.32NA WA CSA EA 374
    rs1905774201,2
    --29474165(+) GCCACC/TGTGCC 1 -- ds50010--------
    rs1814601081,2
    --29474174(+) CCCGGC/TCTACA 1 -- ds50010--------
    rs1136645311,2
    C--29474228(+) GAAAGG/TACAAC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs11308461,2
    C,A,H--29474358(-) aaaaaG/Aaaaag 1 -- ut313Minor allele frequency- A:0.00MN NS NA 410
    rs1859951741,2
    --29474415(+) GTTTAC/TTTCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SRSF4 (29474250 - 29508637 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRSF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509091CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF4
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601940    OMIM disorders: --


    Find genes that share disorders with SRSF4           About GenesLikeMe


    Export disorders for SRSF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRSF4 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with SRSF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human SR proteins and isolation of a cDNA encoding SRp75. (PubMed id 8321209)1, 2, 3 Zahler A.M.... Roth M.B. (Mol. Cell. Biol. 1993)
    2. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. (PubMed id 14578391)1, 2, 9 Zimowska G.... Sugrue S.P. (Invest. Ophthalmol. Vis. Sci. 2003)
    3. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)1, 2 Wang J.... Andreadis A. (J. Neurochem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A coactivator of pre-mRNA splicing. (PubMed id 9531537)1, 2 Blencowe B.J.... Sharp P.A. (Genes Dev. 1998)
    9. SR proteins: a conserved family of pre-mRNA splicing factors. (PubMed id 1577277)1, 2 Zahler A.M.... Roth M.B. (Genes Dev. 1992)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6429 HGNC: 10786 AceView: SFRS4 Ensembl:ENSG00000116350 euGenes: HUgn6429
    ECgene: SRSF4 Kegg: 6429 H-InvDB: SRSF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRSF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRSF4 gene:
    Search GeneIP for patents involving SRSF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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