Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF3 Gene

protein-coding   GIFtS: 59
GCID: GC06P036562

Serine/Arginine-Rich Splicing Factor 3

(Previous names: splicing factor, arginine/serine-rich 3)
(Previous symbol: SFRS3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 31 2     SRP203 5
SFRS31 2 3 5     SRp202
Splicing Factor, Arginine/Serine-Rich 31 2 3     Splicing Factor, Arginine/Serine-Rich, 20-KD2
Pre-MRNA-Splicing Factor SRP202 3     

External Ids:    HGNC: 107851   Entrez Gene: 64282   Ensembl: ENSG000001120817   OMIM: 6033645   UniProtKB: P841033   
ORGUL members:         
NONCODE14:n410149      

Export aliases for SRSF3 gene to outside databases

Previous GC identifer: GC06P036280


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF3 Gene:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,
which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for
binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues
and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA
splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. (provided by
RefSeq, Sep 2010)

GeneCards Summary for SRSF3 Gene: 
SRSF3 (serine/arginine-rich splicing factor 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SRSF3 include open-angle glaucoma, and primary open angle glaucoma, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include RNA binding and phospholipase binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103
Function: May be involved in RNA processing in relation with cellular proliferation and/or maturation

Gene Wiki entry for SRSF3 (SFRS3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

SRSF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036562:  view genomic region     (about GC identifiers)

Start:
36,562,090 bp from pter      End:
36,573,377 bp from pter
Size:
11,288 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 3  
Size: 164 amino acids; 19330 Da
Subunit: Interacts with CPSF6, RBMY1A1 and SREK1/SFRS12
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for SRSF3:
2I2Y (3D)        2I38 (3D)    
Secondary accessions: O08831 P23152 Q5R3K0

Explore the universe of human proteins at neXtProt for SRSF3: NX_P84103

Explore proteomics data for SRSF3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P84103

  • SRSF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRSF3 Protein Expression
    REFSEQ proteins: NP_003008.1  
    ENSEMBL proteins: 
     ENSP00000362820   ENSP00000436036   ENSP00000344762  
    Reactome Protein details: P84103
    Human Recombinant Protein Products for SRSF3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SRSF3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SRSF3
    GenScript Custom Purified and Recombinant Proteins Services for SRSF3
    Novus Biologicals SRSF3 Proteins
    Novus Biologicals SRSF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRSF3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0016607nuclear speck IEA--

    SRSF3 for ontologies           About GeneDecksing



    SRSF3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRSF3
    GenScript Custom Superior Antibodies Services for SRSF3
    Novus Biologicals SRSF3 Antibodies
    Abcam antibodies for SRSF3
    Cloud-Clone Corp. Antibodies for SRSF3 
    Search ThermoFisher Antibodies for SRSF3
    LSBio Antibodies in human, mouse, rat for SRSF3 

    Assay Products for SRSF3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRSF3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRSF3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRSF3 
    Cloud-Clone Corp. CLIAs for SRSF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P84103

    ProtoNet protein and cluster: P84103

    UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SRSF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF3_HUMAN, P84103
    Function: May be involved in RNA processing in relation with cellular proliferation and/or maturation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI14559993
    GO:0043274phospholipase binding IEA--
         
    SRSF3 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for SRSF3:
     Decreased G3BP1 protein expres  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Decreased cell number, increas  Decreased nuclei size in G2M  G0/1 arrest  Increased gamma-H2AX phosphory 
     Metaphase cells 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Srsf3):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 
     normal 

    SRSF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srsf3tm1.1Pjln for SRSF3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRSF3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRSF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRSF3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRSF3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF3
    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF3 (see all 90):
    hsa-miR-548j hsa-miR-640 hsa-miR-3146 hsa-miR-4272 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-3916 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRSF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRSF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRSF3
    Sirion Biotech Customized adenovirus for overexpression of SRSF3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SRSF3 (see all 7)
    OriGene ORF clones in mouse, rat for SRSF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRSF3 (NM_003017)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF3
    Sirion Biotech Customized lentivirus for stable overexpression of SRSF3 
                         Customized lentivirus expression plasmids for stable overexpression of SRSF3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRSF3
    Search LifeMap BioReagents cell lines for SRSF3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRSF3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA Splicing0.82
    mRNA Processing0.85
    mRNA processing0.46
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF3
        mRNA processing

    5/14        Reactome Pathways for SRSF3 (see all 14)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    2         Kegg Pathways  (Kegg details for SRSF3):
        Spliceosome
    Herpes simplex infection


    SRSF3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/708 Interacting proteins for SRSF3 (P841031, 2, 3 ENSP000003628204) via UniProtKB, MINT, STRING, and/or I2D (see all 708)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU92, 3, ENSP000002941724MINT-3379978 MINT-3380604 MINT-3379948 MINT-3380578 I2D: score=2 STRING: ENSP00000294172
    PCBP2Q153662, 3, ENSP000003524384MINT-7945693 MINT-4299293 MINT-4299334 MINT-4299313 I2D: score=1 STRING: ENSP00000352438
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 I2D: score=1 STRING: ENSP00000370083
    EXOSC6Q5RKV62, 3, ENSP000003985974MINT-7945693 I2D: score=3 STRING: ENSP00000398597
    PCBP1Q153652, 3, ENSP000003055564MINT-2863076 I2D: score=3 STRING: ENSP00000305556
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006406mRNA export from nucleus TAS--
    GO:0008380RNA splicing TAS--

    SRSF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRSF3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF3

    2 Novoseek inferred chemical compound relationships for SRSF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 45.2 2 17028590 (1), 16231974 (1)
    arginine 44.9 4 16168628 (2), 16231974 (1)

    Search CenterWatch for drugs/clinical trials and news about SRSF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRSF3 gene: 
    NM_003017.4  

    Unigene Cluster for SRSF3:

    Serine/arginine-rich splicing factor 3
    Hs.405144  [show with all ESTs]
    Unigene Representative Sequence: NR_036610
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373715(uc003omk.3 uc003omj.3) ENST00000477442 ENST00000339436(uc011dtp.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF3
    8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF3 (see all 90):
    hsa-miR-548j hsa-miR-640 hsa-miR-3146 hsa-miR-4272 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-3916 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRSF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRSF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF3
    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF3 (see all 7)
    OriGene ORF clones in mouse, rat for SRSF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRSF3 (NM_003017)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF3
    Sirion Biotech Customized lentivirus for stable overexpression of SRSF3 
                         Customized lentivirus expression plasmids for stable overexpression of SRSF3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRSF3
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRSF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF3
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF3

    Additional mRNA sequence: 

    AB451229.1 AB451352.1 AF107405.1 AK091927.1 AK095580.1 AK304097.1 AK310317.1 AK312553.1 
    AL050041.1 BC000914.1 BC069018.1 BT007017.1 D28423.1 L10838.1 NR_036610.1 

    24/46 DOTS entries (see all 46):

    DT.100692733  DT.100833407  DT.95218077  DT.100692755  DT.100692748  DT.95139007  DT.449814  DT.95309122 
    DT.100692737  DT.100692740  DT.100864012  DT.121356350  DT.121356397  DT.100034834  DT.95132462  DT.92468750 
    DT.95218091  DT.121356383  DT.121356377  DT.100852285  DT.121356374  DT.92468728  DT.95296916  DT.109833 

    24/1483 AceView cDNA sequences (see all 1483):

    BQ231450 BU161889 AA362455 BU193027 BM664198 AA580155 BM848523 BG505364 
    CB996602 AA702507 CA450376 BU172436 AA370243 CD370717 BE671592 AA082035 
    BM090899 AF107405 CR611557 AW055251 CB149254 AI473144 BU517193 BM832819 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e ·
    SP1:                                -                       -           -     -           -     -     -     -                                                   
    SP2:                                -                       -                             -     -     -     -                                                   
    SP3:                                                        -                             -     -     -     -                                                   
    SP4:                                -                       -                 -     -     -     -     -     -     -     -                                       
    SP5:                                -                       -                                                                                                   

    ExUns: 13f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SRSF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF3 expression in normal human tissues (normalized intensities)      SRSF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCATTTG
    SRSF3 Expression
    About this image


    SRSF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See SRSF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF3

    SOURCE GeneReport for Unigene cluster: Hs.405144
        SABiosciences Custom PCR Arrays for SRSF3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRSF3
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRSF3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF3
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRSF3 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf31 , 5 serine/arginine-rich splicing factor 31, 5 91.87(n)1
    100(a)1
      17 (15.03 cM)5
    203831  NM_013663.51  NP_038691.11 
     290326735 
    chicken
    (Gallus gallus)
    Aves SRSF31 serine/arginine-rich splicing factor 3 83.54(n)
    100(a)
      419815  NM_001195554.1  NP_001182483.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF36
    Uncharacterized protein
    99(a)
    1 ↔ 1
    4(123505810-123510181)
    African clawed frog
    (Xenopus laevis)
    Amphibia sfrs3-prov2 splicing factor, arginine/serine-rich 3 79.2(n)    BC046661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sfrs32 splicing factor, arginine/serine-rich 3 73.78(n)   368925  AY398433.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta x166
    --
    36(a)
    1 ↔ 1
    2L(6914300-6920210)


    ENSEMBL Gene Tree for SRSF3 (if available)
    TreeFam Gene Tree for SRSF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF3 gene
    SRSF52  SRSF92  SRSF72  SRSF12  SRSF62  SRSF42  
    7 SIMAP similar genes for SRSF3 using alignment to 1 protein entry:     SRSF3_HUMAN:
    SFRS3    SRSF7    SFRS5    SRSF12    SRSF5    SRSF10
    SFRS2

    SRSF3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for SRSF3
    PGOHUM00000242609 PGOHUM00000240233 PGOHUM00000240241 PGOHUM00000240848 PGOHUM00000233538


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/357 SNPs in SRSF3 are shown (see all 357)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421053941,2
    --36560150(+) AATAAA/CTAACT 2 -- us2k10--------
    rs1924223851,2
    --36560184(+) TTGCTC/TGACTG 2 -- us2k10--------
    rs1844477601,2
    --36560381(+) CTGACC/TCCAGA 2 -- us2k10--------
    rs1888469401,2
    --36560557(+) GAAACC/TAGGCT 2 -- us2k10--------
    rs752369541,2
    F--36560572(+) TGTAAT/GAAATC 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs771803281,2
    --36560584(+) GTATTG/TTTTTC 2 -- us2k10--------
    rs1813138311,2
    --36560954(+) GAGACC/TCCATC 2 -- us2k10--------
    rs755820521,2
    C--36560992(+) AAAAAA/TAAAAC 2 -- us2k10--------
    rs2012175881,2
    C--36560992(+) AAAAA-/AATAAAAC 2 -- cds1 us2k10--------
    rs1151641271,2
    C,F--36561041(+) TAAAAA/TGACAG 2 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for SRSF3 (36562090 - 36573377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRSF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv885806CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF3
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603364    OMIM disorders: --

    13 diseases for SRSF3:    About MalaCards
    open-angle glaucoma    primary open angle glaucoma    glaucoma    bipolar disorder
    herpes simplex    kaposi's sarcoma    asthma    sarcoma
    ovarian cancer    colon cancer    gastric cancer    alzheimer's disease
    breast cancer


    SRSF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRSF3
    Human Genome Epidemiology (HuGE) Navigator: SRSF3 (0 documents)

    Export disorders for SRSF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF3 gene, integrated from 9 sources (see all 106):
    (articles sorted by number of sources associating them with SRSF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SR proteins: a conserved family of pre-mRNA splicing factors. (PubMed id 1577277)1, 2, 3 Zahler A.M.... Roth M.B. (1992)
    2. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    3. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PubMed id 10757789)1, 2 Barnard D.C. and Patton J.G. (2000)
    6. Control of the papillomavirus early-to-late switch by differentially expressed SRp20. (PubMed id 18945760)1, 9 Jia R....Zheng Z.M. (2009)
    7. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. (PubMed id 19047369)1, 9 Sen S....Webster N.J. (2009)
    8. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PubMed id 17036044)1, 9 Hargous Y....Allain F.H. (2006)
    9. Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. (PubMed id 19250906)1, 9 Loomis R.J....Chakravarti D. (2009)
    10. RNA polymerase II C-terminal domain mediates regulation of alternative splicing by SRp20. (PubMed id 17028590)1, 9 de la Mata M. and Kornblihtt A.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6428 HGNC: 10785 AceView: SFRS3 Ensembl:ENSG00000112081 euGenes: HUgn6428
    ECgene: SRSF3 Kegg: 6428 H-InvDB: SRSF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRSF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRSF3 gene:
    Search GeneIP for patents involving SRSF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF3
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SRSF3  
     OriGene qPCR primer pairs and template standards for SRSF3   OriGene Protein Over-expression Lysate for SRSF3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SRSF3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRSF3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SRSF3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRSF3   OriGene Custom Protein Services for SRSF3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRSF3
     QIAGEN SeqTarget long-range PCR primers for resequencing SRSF3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF3
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF3
     GenScript Custom Purified and Recombinant Proteins Services for SRSF3 GenScript cDNA clones with any tag delivered in your preferred vector for SRSF3
     GenScript Custom Assay Services for SRSF3 GenScript Custom Superior Antibodies Services for SRSF3
     GenScript Custom overexpressing Cell Line Services for SRSF3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for SRSF3
     Search Chromatin IP Primers for SRSF3
     RT2 qPCR Primer Assay in human, mouse, rat SRSF3
     Search GNC Networks for SRSF3
     SABiosciences Custom PCR Arrays for SRSF3
     Search Tocris compounds for SRSF3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SRSF3 antibodies
     SRSF3 proteins
     SRSF3 lysates
     Antibodies for SRSF3
     See all of Abcam's Antibodies, Kits and Proteins for SRSF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SRSF3
     Antibodies for SRSF3
     ELISAs for SRSF3
     CLIAs for SRSF3
     Search LifeMap BioReagents cell lines for SRSF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF3
     SwitchGear 3'UTR luciferase reporter plasmids for SRSF3
     SwitchGear Promoter luciferase reporter plasmids for SRSF3
     Search ThermoFisher Antibodies for SRSF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SRSF3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRSF3
    Customized:
     lentivirus for stable overexpression of SRSF3
     lentivirus expression plasmids for stable overexpression of SRSF3
     adenovirus for overexpression of SRSF3
     LSBio Antibodies in human, mouse, rat for SRSF3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRSF3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4