Aliases for SRSF3 Gene
External Ids for SRSF3 Gene
Previous HGNC Symbols for SRSF3 Gene
Previous GeneCards Identifiers for SRSF3 Gene
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
GeneCards Summary for SRSF3 Gene
SRSF3 (Serine/Arginine-Rich Splicing Factor 3) is a Protein Coding gene. Diseases associated with SRSF3 include Ocular Hypertension. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF4.
UniProtKB/Swiss-Prot for SRSF3 Gene
May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.