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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SRSF3 Gene

protein-coding GIFtS: 56
GCID: GC06P036562

serine/arginine-rich splicing factor 3

(Previous names: splicing factor, arginine/serine-rich 3 )
(Previous symbol: SFRS3)

Explore 9 diseases affiliated with
SRSF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 3¹ ²		Pre-MRNA-Splicing Factor SRP20² ³
SFRS3¹ ² ³ ⁵		SRP20³ ⁵
Splicing Factor, Arginine/Serine-Rich 3¹ ² ³		Splicing Factor, Arginine/Serine-Rich, 20-KD²
SRp20¹ ²

External Ids:	HGNC: 10785¹	Entrez Gene: 6428²	Ensembl: ENSG00000112081⁷	OMIM: 603364⁵	UniProtKB: P84103³

ORGUL members:
	NONCODE:n410149

Export aliases for SRSF3 gene to outside databases

Previous GC identifer: GC06P036280

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF3:

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,

which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding

RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates

interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins

have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one

protein-coding and the other non-coding, have been found for this gene. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103

Function: May be involved in RNA processing in relation with cellular proliferation and/or maturation

Gene Wiki entry for SRSF3 (SFRS3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SRSF3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRSF3 promoter sequence

Search SABiosciences Chromatin IP Primers for SRSF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21

SRSF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF3 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P036562: view genomic region (about GC identifiers)

Start:	36,562,090 bp from pter	End:	36,572,244 bp from pter
Size:	10,155 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103 (See protein sequence)

Recommended Name: Serine/arginine-rich splicing factor 3

Size: 164 amino acids; 19330 Da

Subunit: Interacts with CPSF6, RBMY1A1 and SREK1/SFRS12

Subcellular location: Nucleus

2 PDB 3D structures from and Proteopedia for SRSF3:

2I2Y (3D)

2I38 (3D)

Secondary accessions: O08831 P23152 Q5R3K0

Explore the universe of human proteins at neXtProt for SRSF3: NX_P84103

Post-translational modifications:

Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain (By

similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P84103

SRSF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003008.1

ENSEMBL proteins:

ENSP00000362820 ENSP00000436036 ENSP00000344762

Reactome Protein details: P84103
Human Recombinant Protein Products:

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	Uscn Proteins for SRSF3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0016607	nuclear speck	IEA	--

SRSF3 for ontologies About GeneDecksing

SRSF3 Antibody Products:

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Assay Products for SRSF3:

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	Uscn ELISAs and CLIAs for SRSF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SRSF3 for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry P84103

ProtoNet protein and cluster: P84103

UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103

Similarity: Belongs to the splicing factor SR family

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103

Function: May be involved in RNA processing in relation with cellular proliferation and/or maturation

miRNA Products:		OriGene 3'-UTR Clone: SRSF3 Browse MicroRNA Expression Plasmids
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		hsa-miR-548j hsa-miR-640 hsa-miR-3146 hsa-miR-4272 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-3916 hsa-miR-502-3p

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF3

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	14559993
GO:0043274	phospholipase binding	IEA	--

SRSF3 for ontologies About GeneDecksing

9 GenomeRNAi human phenotypes for SRSF3:

Decreased G3BP1 protein expres	Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e
Decreased cell number, increas	Decreased nuclei size in G2M	G0/1 arrest	Increased gamma-H2AX phosphory
Metaphase cells

Animal Models:
Mouse knock-out Srsf3^tm1.1Pjln for SRSF3
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Srsf3):

cellular

hematopoietic system

immune system

mortality/aging

normal

SRSF3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA Processing	0.82
mRNA Splicing - Major Pathway	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31

RNA Polymerase II Transcription Termination

RNA Polymerase II Transcription Termination	1.00	Post-Elongation Processing of Intron-Containing pre-mRNA	0.79
Post-Elongation Processing of the Transcript	1.00	mRNA 3'-end processing	0.79
Cleavage of Growing Transcript in the Termination Region	1.00

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

Transport of Mature Transcript to Cytoplasm

Transport of Mature Transcript to Cytoplasm

1.00

Transport of Mature mRNA derived from an Intron-Containing Transcript

0.85

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SRSF3

mRNA processing

5/14 Reactome Pathways for SRSF3 (see all 14)

	Transport of Mature mRNA derived from an Intron-Containing Transcript
	mRNA Splicing - Major Pathway
	Transport of Mature Transcript to Cytoplasm
	mRNA Splicing
	RNA Polymerase II Transcription

1 Kegg Pathway (Kegg details for SRSF3):

Spliceosome

SRSF3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SRSF3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/675 Interacting proteins for SRSF3 (P84103^{1, 2, 3} ENSP00000362820⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 675)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NXF1	Q9UBU9²^,³, ENSP00000294172⁴	MINT-3379978 MINT-3380604 MINT-3379948 MINT-3380578 I2D: score=2 STRING: ENSP00000294172
PCBP2	Q15366²^,³, ENSP00000352438⁴	MINT-7945693 MINT-4299293 MINT-4299334 MINT-4299313 I2D: score=1 STRING: ENSP00000352438
SMN1	Q16637²^,³, ENSP00000370083⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000370083
EXOSC6	Q5RKV6²^,³, ENSP00000398597⁴	MINT-7945693 I2D: score=3 STRING: ENSP00000398597
PCBP1	Q15365²^,³, ENSP00000305556⁴	MINT-2863076 I2D: score=3 STRING: ENSP00000305556

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006369	termination of RNA polymerase II transcription	TAS	--
GO:0006406	mRNA export from nucleus	TAS	--
GO:0008380	RNA splicing	TAS	--

SRSF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SRSF3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SRSF3
2 Novoseek chemical compound relationships for SRSF3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
serine	45.2	2	17028590 (1), 16231974 (1)
arginine	44.9	4	16168628 (2), 16231974 (1)

Search CenterWatch for drugs/clinical trials and news about SRSF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SRSF3 gene:

NM_003017.4

Unigene Cluster for SRSF3:

Serine/arginine-rich splicing factor 3

Hs.405144 [show with all ESTs]

Unigene Representative Sequence: NR_036610

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373715(uc003omk.3 uc003omj.3) ENST00000477442 ENST00000339436(uc011dtp.1)

miRNA Products:		OriGene 3'-UTR Clone: SRSF3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF3
		8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF3 (see all 90):
		hsa-miR-548j hsa-miR-640 hsa-miR-3146 hsa-miR-4272 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-3916 hsa-miR-502-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SRSF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF3 (see all 4) OriGene shRNA RFP: SRSF3 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF3

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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF3

Additional cDNA sequence:

AB451229.1 AB451352.1 AF107405.1 AK091927.1 AK095580.1 AK304097.1 AK310317.1 AK312553.1

AL050041.1 BC000914.1 BC069018.1 BT007017.1 D28423.1 L10838.1 NR_036610.1

24/45 DOTS entries (see all 45):

DT.100692733 DT.100833407 DT.95218077 DT.100692755 DT.95139007 DT.449814 DT.100692748 DT.95309122

DT.100692737 DT.100692740 DT.100864012 DT.121356350 DT.121356397 DT.100034834 DT.95132462 DT.92468750

DT.121356383 DT.95218091 DT.121356377 DT.121356374 DT.109833 DT.95296916 DT.121356393 DT.92468728

24/1483 AceView cDNA sequences (see all 1483):

BU150638 AA968739 BQ213241 BM771272 BQ719044 BP370250 BI820730 AA312870

CA441461 AI754141 BQ439033 BE242933 BQ723119 CA430618 AW189952 BM836293

BM458133 AA314828 BM679258 CD358317 BF831625 BG029598 BE794505 BU956970

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF3 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c	·	13d	·	13e	·
SP1:											-								-				-		-				-		-		-		-
SP2:											-								-										-		-		-		-
SP3:																			-										-		-		-		-
SP4:											-								-						-		-		-		-		-		-		-		-
SP5:											-								-

ExUns:	13f
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SRSF3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SRSF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTCATTTG

About this image

SRSF3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SRSF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRSF3

SOURCE GeneReport for Unigene cluster: Hs.405144

SABiosciences Custom PCR Arrays for SRSF3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF3 Browse OriGene validated miRNA SYBR primer pairs
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		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRSF3 gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SRSF3¹	serine/arginine-rich splicing factor 3	83.54(n) 100(a)		419815 NM_001195554.1 NP_001182483.1
lizard (Anolis carolinensis)	Reptilia	SRSF3⁶	--	99(a)	1 ↔ 1	4(123505810-123510181)
African clawed frog (Xenopus laevis)	Amphibia	sfrs3-prov²	splicing factor, arginine/serine-rich 3	79.2(n)		BC046661.1
zebrafish (Danio rerio)	Actinopterygii	sfrs3²	splicing factor, arginine/serine-rich 3	73.78(n)		368925 AY398433.1
fruit fly (Drosophila melanogaster)	Insecta	x16⁶	--	29(a)	1 ↔ 1	2L(6914300-6920210)
worm (Caenorhabditis elegans)	Secernentea	rsp-6⁶	Probable splicing factor, arginine/serine-rich 6	29(a)	possible ortholog	IV(7789833-7791223)
thale cress (Arabidopsis thaliana)	eudicotyledons	SRZ-22⁶ RSZ22a⁶ (see all 5)	protein serine/arginine-rich 22 RNA recognition motif and CCHC-type zinc finger do... (see all 5)	26(a) 26(a) (see all 5)	many ↔ many many ↔ many (see all 5)	4(15306654-15308347) 2(10449631-10451184)
rice (Oryza sativa)	Liliopsida	-- -- (see all 7)	RNA recognition motif containing protein, expresse... RNA recognition motif containing protein, expresse... (see all 7)	28(a) 26(a) (see all 7)	many ↔ many many ↔ many (see all 7)	6(4427667-4431337) 2(33535992-33540669)

ENSEMBL Gene Tree for SRSF3 (if available)
TreeFam Gene Tree for SRSF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SRSF3 gene

LOC100996657² SRSF4² SRSF12² SRSF10² SRSF9² SRSF5² SRSF2² SRSF7²

SRSF1² SRSF6²

9 SIMAP similar genes for SRSF3 using alignment to 1 protein entry: SRSF3_HUMAN:

SFRS3 SRSF7 SFRS5 SRSF12 SRSF5 SRSF10

SFRS2 SRSF2 SRSF8

SRSF3 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for SRSF3
PGOHUM00000242609 PGOHUM00000240233 PGOHUM00000240241 PGOHUM00000240848 PGOHUM00000233538

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142105394^1,2		--	36560150(+)	`AATAAA/CTAACT`	2	--	us2k¹		0	--	--	--	--
rs192422385^1,2		--	36560184(+)	`TTGCTC/TGACTG`	2	--	us2k¹		0	--	--	--	--
rs184447760^1,2		--	36560381(+)	`CTGACC/TCCAGA`	2	--	us2k¹		0	--	--	--	--
rs188846940^1,2		--	36560557(+)	`GAAACC/TAGGCT`	2	--	us2k¹		0	--	--	--	--
rs75236954^1,2	F,	--	36560572(+)	`TGTAAT/GAAATC`	2	--	us2k¹		1		WA	118
rs77180328^1,2		--	36560584(+)	`GTATTG/TTTTTC`	2	--	us2k¹		0	--	--	--	--
rs181313831^1,2		--	36560954(+)	`GAGACC/TCCATC`	2	--	us2k¹		0	--	--	--	--
rs75582052^1,2	C	--	36560992(+)	`AAAAAA/TAAAAC`	2	--	us2k¹		0	--	--	--	--
rs115164127^1,2	F,	--	36561041(+)	`TAAAAA/TGACAG`	2	--	us2k¹		1		NA	120
rs183990591^1,2		--	36561076(+)	`TGTGCA/GGTGGT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SRSF3 (36562090 - 36572244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SRSF3: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SRSF3 for disorders           About GeneDecksing

OMIM gene information: 603364    OMIM disorders: --

9 diseases for SRSF3:    About MalaCards

open-angle glaucoma primary open angle glaucoma glaucoma herpes simplex

bipolar disorder ovarian cancer asthma ataxia

malaria

Human Genome Epidemiology (HuGE) Navigator: SRSF3 (0 documents)

Export disorders for SRSF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SRSF3 gene, integrated from 9 sources (see all 92):
(articles sorted by number of sources associating them with SRSF3)

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SR proteins: a conserved family of pre-mRNA splicing factors. (PubMed id 1577277)^{1, 2, 3} Zahler A.M.... Roth M.B. (1992)
A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)^{1, 3} Manley J.L. and Krainer A.R. (2010)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)^{1, 2} Dettwiler S.... Barabino S.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PubMed id 10757789)^{1, 2} Barnard D.C. and Patton J.G. (2000)
Control of the papillomavirus early-to-late switch by differentially expressed SRp20. (PubMed id 18945760)^{1, 9} Jia R....Zheng Z.M. (2009)
SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. (PubMed id 19047369)^{1, 9} Sen S....Webster N.J. (2009)
Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PubMed id 17036044)^{1, 9} Hargous Y....Allain F.H. (2006)
Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. (PubMed id 19250906)^{1, 9} Loomis R.J....Chakravarti D. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6428	HGNC: 10785	AceView: SFRS3	Ensembl:ENSG00000112081	euGenes: HUgn6428
ECgene: SRSF3	Kegg: 6428	H-InvDB: SRSF3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SRSF3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SRSF3 gene
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serine/arginine-rich splicing factor 3

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serine/arginine-rich splicing factor 3

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