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SRSF3 Gene

protein-coding   GIFtS: 58
GCID: GC06P036562

Serine/Arginine-Rich Splicing Factor 3

(Previous names: splicing factor, arginine/serine-rich 3)
(Previous symbol: SFRS3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine-Rich Splicing Factor 31 2     SRP203 5
SFRS31 2 3 5     SRp202
Splicing Factor, Arginine/Serine-Rich 31 2 3     Splicing Factor, Arginine/Serine-Rich, 20-KD2
Pre-MRNA-Splicing Factor SRP202 3     

External Ids:    HGNC: 107851   Entrez Gene: 64282   Ensembl: ENSG000001120817   OMIM: 6033645   UniProtKB: P841033   

Export aliases for SRSF3 gene to outside databases

Previous GC identifer: GC06P036280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRSF3 Gene:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,
which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for
binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues
and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA
splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. (provided by
RefSeq, Sep 2010)

GeneCards Summary for SRSF3 Gene:
SRSF3 (serine/arginine-rich splicing factor 3) is a protein-coding gene. Diseases associated with SRSF3 include ocular hypertension, and dysautonomia. GO annotations related to this gene include RNA binding and phospholipase binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103
Function: May be involved in RNA processing in relation with cellular proliferation and/or maturation. May
function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to
be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding
activity. RNA-binding is semi-sequence specific

Gene Wiki entry for SRSF3 (SFRS3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF3 promoter sequence
   Search Chromatin IP Primers for SRSF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

SRSF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P036562:  view genomic region     (about GC identifiers)

Start:
36,562,090 bp from pter      End:
36,573,377 bp from pter
Size:
11,288 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 3  
Size: 164 amino acids; 19330 Da
Subunit: Interacts with CPSF6, RBMY1A1 and SREK1/SFRS12. Interacts with NXF1
2 PDB 3D structures from and Proteopedia for SRSF3:
2I2Y (3D)        2I38 (3D)    
Secondary accessions: O08831 P23152 Q5R3K0

Explore the universe of human proteins at neXtProt for SRSF3: NX_P84103

Explore proteomics data for SRSF3 at MOPED

Post-translational modifications: 

  • Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain (By
    similarity)1
  • Ubiquitination2 at Lys23, Lys85
  • Modification sites at PhosphoSitePlus

  • See SRSF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003008.1  
    ENSEMBL proteins: 
     ENSP00000362820   ENSP00000436036   ENSP00000344762  
    Reactome Protein details: P84103

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    Cloud-Clone Corp. CLIAs for SRSF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry P84103

    ProtoNet protein and cluster: P84103

    UniProtKB/Swiss-Prot: SRSF3_HUMAN, P84103
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SRSF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF3_HUMAN, P84103
    Function: May be involved in RNA processing in relation with cellular proliferation and/or maturation. May
    function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to
    be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding
    activity. RNA-binding is semi-sequence specific

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS2030943
    GO:0005515protein binding IPI14559993
    GO:0043274phospholipase binding ----
         
    SRSF3 for ontologies           About GeneDecksing


    Phenotypes:
         9 GenomeRNAi human phenotypes for SRSF3:
     Decreased G3BP1 protein expres  Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 
     Decreased cell number, increas  Decreased nuclei size in G2M  G0/1 arrest  Increased gamma-H2AX phosphory 
     Metaphase cells 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Srsf3):
     embryogenesis  hematopoietic system  immune system  mortality/aging  normal 

    SRSF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srsf3tm1.1Pjln for SRSF3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF3
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    miRNA
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    miRTarBase miRNAs that target SRSF3:
    hsa-mir-361-5p (MIRT020093), hsa-mir-186-5p (MIRT021093), hsa-mir-124-3p (MIRT022320)

    Block miRNA regulation of human, mouse, rat SRSF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF3 (see all 90):
    hsa-miR-548j hsa-miR-640 hsa-miR-3146 hsa-miR-4272 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-3916 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRSF3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRSF3_HUMAN, P84103: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck ----

    SRSF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRSF3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF3
        mRNA processing


    4 Reactome Pathways for SRSF3
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


    2 Kegg Pathways  (Kegg details for SRSF3):
        Spliceosome
    Herpes simplex infection


    SRSF3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF3
    Interactions:

        Search GeneGlobe Interaction Network for SRSF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRSF3 (P841031, 2, 3 ENSP000003628204) via UniProtKB, MINT, STRING, and/or I2D (see all 715)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU91, 2, 3, ENSP000002941724EBI-372557,EBI-398874 MINT-3379978 MINT-3380604 MINT-3379948 MINT-3380578 I2D: score=2 STRING: ENSP00000294172
    PCBP2Q153661, 2, 3, ENSP000003524384EBI-372557,EBI-945799 MINT-7945693 MINT-4299293 MINT-4299334 MINT-4299313 I2D: score=1 STRING: ENSP00000352438
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 I2D: score=1 STRING: ENSP00000370083
    EXOSC6Q5RKV62, 3, ENSP000003985974MINT-7945693 I2D: score=3 STRING: ENSP00000398597
    PCBP1Q153652, 3, ENSP000003055564MINT-2863076 I2D: score=3 STRING: ENSP00000305556
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006406mRNA export from nucleus TAS--
    GO:0008380RNA splicing TAS--

    SRSF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF3

    2 Novoseek inferred chemical compound relationships for SRSF3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 45.2 2 17028590 (1), 16231974 (1)
    arginine 44.9 4 16168628 (2), 16231974 (1)



    SRSF3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRSF3 gene: 
    NM_003017.4  

    Unigene Cluster for SRSF3:

    Serine/arginine-rich splicing factor 3
    Hs.405144  [show with all ESTs]
    Unigene Representative Sequence: NR_036610
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373715(uc003omk.3 uc003omj.3) ENST00000477442 ENST00000339436(uc011dtp.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRSF3 (see all 90):
    hsa-miR-548j hsa-miR-640 hsa-miR-3146 hsa-miR-4272 hsa-miR-342-3p hsa-miR-371-5p hsa-miR-3916 hsa-miR-502-3p
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    Additional mRNA sequence: 

    AB451229.1 AB451352.1 AF107405.1 AK091927.1 AK095580.1 AK304097.1 AK310317.1 AK312553.1 
    AL050041.1 BC000914.1 BC069018.1 BT007017.1 D28423.1 L10838.1 NR_036610.1 

    Selected DOTS entries (see all 46):

    DT.100692733  DT.100833407  DT.95218077  DT.100692755  DT.100692748  DT.95139007  DT.449814  DT.95309122 
    DT.100692737  DT.100692740  DT.100864012  DT.121356350  DT.121356397  DT.100034834  DT.95132462  DT.92468750 
    DT.95218091  DT.121356383  DT.121356377  DT.100852285  DT.121356374  DT.92468728  DT.95296916  DT.109833 

    Selected AceView cDNA sequences (see all 1483):

    BX456353 BF665625 AI143628 AA936798 F11909 BM904316 CD656478 AI635722 
    AI142330 BM788530 CA423558 AI611139 BQ015376 AU280718 AI378088 BM832819 
    AV656439 BM553724 BQ432341 BM826615 AA676924 CD370717 BM699090 AW575053 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRSF3 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e ·
    SP1:                                -                       -           -     -           -     -     -     -                                                   
    SP2:                                -                       -                             -     -     -     -                                                   
    SP3:                                                        -                             -     -     -     -                                                   
    SP4:                                -                       -                 -     -     -     -     -     -     -     -                                       
    SP5:                                -                       -                                                                                                   

    ExUns: 13f
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SRSF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRSF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTCATTTG
    SRSF3 Expression
    About this image


    SRSF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Secondary Spermatocyte Seminiferous Tubules
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    SRSF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405144
        Custom PCR Arrays for SRSF3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRSF3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf31 , 5 serine/arginine-rich splicing factor 31, 5 91.87(n)1
    100(a)1
      17 (15.03 cM)5
    203831  NM_013663.51  NP_038691.11 
     290326735 
    chicken
    (Gallus gallus)
    Aves SRSF31 serine/arginine-rich splicing factor 3 83.54(n)
    100(a)
      419815  NM_001195554.1  NP_001182483.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF36
    serine/arginine-rich splicing factor 3
    99(a)
    1 ↔ 1
    4(123505810-123510181)
    African clawed frog
    (Xenopus laevis)
    Amphibia sfrs3-prov2 splicing factor, arginine/serine-rich 3 79.2(n)    BC046661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sfrs32 splicing factor, arginine/serine-rich 3 73.78(n)   368925  AY398433.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-66
    Protein RSP-6, isoform c (rsp-6) mRNA, complete cd...
    48(a)
    1 ↔ 1
    IV(7789845-7791235) WBGene00004703


    ENSEMBL Gene Tree for SRSF3 (if available)
    TreeFam Gene Tree for SRSF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRSF3 gene
    SRSF52  SRSF92  SRSF72  SRSF12  SRSF62  SRSF42  
    7 SIMAP similar genes for SRSF3 using alignment to 1 protein entry:     SRSF3_HUMAN:
    SFRS3    SRSF7    SFRS5    SRSF12    SRSF5    SRSF10
    SFRS2

    SRSF3 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for SRSF3
    PGOHUM00000242609 PGOHUM00000240233 PGOHUM00000240241 PGOHUM00000240848 PGOHUM00000233538


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRSF3 (see all 357)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421053941,2
    --36560150(+) AATAAA/CTAACT 2 -- us2k10--------
    rs1924223851,2
    --36560184(+) TTGCTC/TGACTG 2 -- us2k10--------
    rs1844477601,2
    --36560381(+) CTGACC/TCCAGA 2 -- us2k10--------
    rs1888469401,2
    --36560557(+) GAAACC/TAGGCT 2 -- us2k10--------
    rs752369541,2
    F--36560572(+) TGTAAT/GAAATC 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs771803281,2
    --36560584(+) GTATTG/TTTTTC 2 -- us2k10--------
    rs1813138311,2
    --36560954(+) GAGACC/TCCATC 2 -- us2k10--------
    rs755820521,2
    C--36560992(+) AAAAAA/TAAAAC 2 -- us2k10--------
    rs2012175881,2
    C--36560992(+) AAAAA-/AATAAAAC 2 -- cds1 us2k10--------
    rs1151641271,2
    C,F--36561041(+) TAAAAA/TGACAG 2 -- us2k11Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for SRSF3 (36562090 - 36573377 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRSF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885806CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF3
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603364    OMIM disorders: --

    Selected diseases for SRSF3 (see all 21):    
    About MalaCards
    ocular hypertension    dysautonomia    open-angle glaucoma    primary open angle glaucoma
    glaucoma    scleroderma    herpes simplex    kaposi's sarcoma
    bipolar disorder    sarcoma    asthma    tonsillitis
    ataxia    ovarian cancer    hypertension    alzheimer's disease
    thyroiditis    breast cancer    cerebritis    prostatitis


    SRSF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRSF3
    Human Genome Epidemiology (HuGE) Navigator: SRSF3 (0 documents)

    Export disorders for SRSF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRSF3 gene, integrated from 10 sources (see all 110):
    (articles sorted by number of sources associating them with SRSF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SR proteins: a conserved family of pre-mRNA splicing factors. (PubMed id 1577277)1, 2, 3 Zahler A.M.... Roth M.B. (Genes Dev. 1992)
    2. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PubMed id 17036044)1, 2, 9 Hargous Y....Allain F.H. (EMBO J. 2006)
    3. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. (PubMed id 11336712)1, 2, 9 Huang Y. and Steitz J.A. (Mol. Cell 2001)
    4. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    5. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PubMed id 15169763)1, 2 Dettwiler S.... Barabino S.M. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. (PubMed id 10757789)1, 2 Barnard D.C. and Patton J.G. (Mol. Cell. Biol. 2000)
    8. Control of the papillomavirus early-to-late switch by differentially expressed SRp20. (PubMed id 18945760)1, 9 Jia R....Zheng Z.M. (J. Virol. 2009)
    9. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. (PubMed id 19047369)1, 9 Sen S....Webster N.J. (Mol. Cell. Biol. 2009)
    10. Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. (PubMed id 19250906)1, 9 Loomis R.J....Chakravarti D. (Mol. Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6428 HGNC: 10785 AceView: SFRS3 Ensembl:ENSG00000112081 euGenes: HUgn6428
    ECgene: SRSF3 Kegg: 6428 H-InvDB: SRSF3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRSF3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRSF3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SRSF3 gene:
    Search GeneIP for patents involving SRSF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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