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Aliases for SRSF3 Gene

Aliases for SRSF3 Gene

  • Serine And Arginine Rich Splicing Factor 3 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 3 2 3 4
  • Serine/Arginine-Rich Splicing Factor 3 2 3
  • Pre-MRNA-Splicing Factor SRP20 3 4
  • SRp20 3 4
  • SFRS3 3 4
  • Splicing Factor, Arginine/Serine-Rich, 20-KD 3
  • Pre-MRNA Splicing Factor SRp20 3

External Ids for SRSF3 Gene

Previous HGNC Symbols for SRSF3 Gene

  • SFRS3

Previous GeneCards Identifiers for SRSF3 Gene

  • GC06P036562
  • GC06P036280
  • GC06P036928
  • GC06P036964
  • GC06P037790
  • GC06P038413
  • GC06P039002
  • GC06P039591

Summaries for SRSF3 Gene

Entrez Gene Summary for SRSF3 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF3 Gene

SRSF3 (Serine And Arginine Rich Splicing Factor 3) is a Protein Coding gene. Diseases associated with SRSF3 include Ocular Hypertension. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF7.

UniProtKB/Swiss-Prot for SRSF3 Gene

  • Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export such as of histone H2A (PubMed:11336712, PubMed:18364396). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). RNA-binding is semi-sequence specific (PubMed:17036044).

Gene Wiki entry for SRSF3 Gene

Additional gene information for SRSF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF3 Gene

Genomics for SRSF3 Gene

Regulatory Elements for SRSF3 Gene

Enhancers for SRSF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H036592 3 FANTOM5 Ensembl ENCODE dbSUPER 61.7 +3.1 3106 10 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A SRSF3 KCTD20 CDKN1A LAP3P2 RAB44 STK38 ENSG00000237719 FKBP5 BRPF3 RNU1-88P
GH06H035723 1.8 FANTOM5 ENCODE dbSUPER 61.4 -865.2 -865216 10 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MCM3 NFYC ZC3H11A TAF11 SRSF3 ENSG00000272374 ZNF76 RPL10A STK38 ENSG00000219023 FANCE PPARD ENSG00000228559
GH06H036675 1.5 ENCODE dbSUPER 61.4 +86.5 86537 10 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 SRSF3 CMTR1 RNU1-88P C6orf89 STK38 RNF8 LAP3P2 MAPK14 RN7SL502P ARMC12
GH06H036983 1.4 ENCODE dbSUPER 44.1 +391.4 391428 3 HDGF MLX ARNT ARID4B SIN3A DMAP1 YBX1 YY1 ZNF416 ZNF143 CMTR1 SRSF3 BRPF3 TBC1D22B LAP3P2 RNU1-88P RN7SL285P RN7SL502P ENSG00000237719 RNF8
GH06H037201 1.3 ENCODE dbSUPER 39.2 +609.3 609278 3 HDGF PKNOX1 FOXA2 ARNT YBX1 FEZF1 ZNF207 FOS MCM3 MCM5 SRSF3 STK38 PIM1 TBC1D22B CMTR1 CDKN1A RAB44 COX6A1P2 PIR49359
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRSF3 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196229 987 3801 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A

Genomic Location for SRSF3 Gene

Chromosome:
6
Start:
36,594,313 bp from pter
End:
36,605,600 bp from pter
Size:
11,288 bases
Orientation:
Plus strand

Genomic View for SRSF3 Gene

Genes around SRSF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF3 Gene

Proteins for SRSF3 Gene

  • Protein details for SRSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84103-SRSF3_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 3
    Protein Accession:
    P84103
    Secondary Accessions:
    • B4E241
    • O08831
    • P23152
    • Q5R3K0

    Protein attributes for SRSF3 Gene

    Size:
    164 amino acids
    Molecular mass:
    19330 Da
    Quaternary structure:
    • Interacts with CPSF6 (PubMed:15169763). Interacts with RBMY1A1 (PubMed:15595951). Interacts with SREK1/SFRS12 (PubMed:10757789). Interacts with NXF1 (PubMed:12667464, PubMed:17036044). Interacts with YTHDC1, leading to recruitment to RNA elements adjacent to m6A sites (PubMed:26876937).

    Three dimensional structures from OCA and Proteopedia for SRSF3 Gene

    Alternative splice isoforms for SRSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF3 Gene

Post-translational modifications for SRSF3 Gene

  • Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.
  • Ubiquitination at Lys23 and posLast=8585
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF3 Gene

Antibody Products

No data available for DME Specific Peptides for SRSF3 Gene

Domains & Families for SRSF3 Gene

Gene Families for SRSF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SRSF3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P84103

UniProtKB/Swiss-Prot:

SRSF3_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF3: view

Function for SRSF3 Gene

Molecular function for SRSF3 Gene

UniProtKB/Swiss-Prot Function:
Splicing factor that specifically promotes exon-inclusion during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). Also functions as export adapter involved in mRNA nuclear export such as of histone H2A (PubMed:11336712, PubMed:18364396). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). RNA-binding is semi-sequence specific (PubMed:17036044).

Phenotypes From GWAS Catalog for SRSF3 Gene

Gene Ontology (GO) - Molecular Function for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,TAS 22658674
GO:0005515 protein binding IPI 10823932
GO:1990825 sequence-specific mRNA binding IEA --
genes like me logo Genes that share ontologies with SRSF3: view
genes like me logo Genes that share phenotypes with SRSF3: view

Animal Models for SRSF3 Gene

MGI Knock Outs for SRSF3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF3 Gene

Localization for SRSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF3 Gene

Nucleus. Nucleus speckle. Cytoplasm. Note=Recruited to nuclear speckles following interaction with YTHDC1. {ECO:0000269 PubMed:26876937}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF3 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016607 nuclear speck IEA,IDA 26876937
genes like me logo Genes that share ontologies with SRSF3: view

Pathways & Interactions for SRSF3 Gene

genes like me logo Genes that share pathways with SRSF3: view

Pathways by source for SRSF3 Gene

SIGNOR curated interactions for SRSF3 Gene

Activates:

Gene Ontology (GO) - Biological Process for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF3: view

Drugs & Compounds for SRSF3 Gene

(2) Drugs for SRSF3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SRSF3: view

Transcripts for SRSF3 Gene

Unigene Clusters for SRSF3 Gene

Serine/arginine-rich splicing factor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - -
SP10: - - - - - -
SP11:
SP12: - -

ExUns: 13f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SRSF3 Gene

GeneLoc Exon Structure for
SRSF3
ECgene alternative splicing isoforms for
SRSF3

Expression for SRSF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF3 Gene



Protein tissue co-expression partners for SRSF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF3 Gene:

SRSF3

SOURCE GeneReport for Unigene cluster for SRSF3 Gene:

Hs.405144

Evidence on tissue expression from TISSUES for SRSF3 Gene

  • Nervous system(5)
  • Lung(4.3)
  • Liver(4)
  • Kidney(3.8)
  • Pancreas(3.8)
  • Skin(3.7)
  • Intestine(3.6)
  • Blood(3.2)
  • Eye(3)
  • Bone marrow(2.2)
  • Heart(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with SRSF3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF3 Gene

Orthologs for SRSF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF3 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia SRSF3 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRSF3 34 33
  • 99.59 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF3 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm12355 34
  • 96 (a)
OneToOne
Srsf3 16 33
  • 91.87 (n)
cow
(Bos Taurus)
Mammalia SRSF3 34 33
  • 94.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF3 34 33
  • 94.72 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf3 33
  • 93.5 (n)
chicken
(Gallus gallus)
Aves SRSF3 33 34
  • 83.54 (n)
lizard
(Anolis carolinensis)
Reptilia SRSF3 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf3 33
  • 80.28 (n)
African clawed frog
(Xenopus laevis)
Amphibia sfrs3-prov 33
zebrafish
(Danio rerio)
Actinopterygii srsf3b 34
  • 94 (a)
OneToMany
srsf3a 34
  • 85 (a)
OneToMany
sfrs3 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11030 33
worm
(Caenorhabditis elegans)
Secernentea rsp-6 34
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9083 34
  • 58 (a)
OneToOne
Species where no ortholog for SRSF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF3 Gene

ENSEMBL:
Gene Tree for SRSF3 (if available)
TreeFam:
Gene Tree for SRSF3 (if available)

Paralogs for SRSF3 Gene

Paralogs for SRSF3 Gene

(7) SIMAP similar genes for SRSF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SRSF3: view

Variants for SRSF3 Gene

Sequence variations from dbSNP and Humsavar for SRSF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000010768 -- 36,598,199(+) TTTTC(-/AAGGAT)AAATG intron-variant
rs1000084353 -- 36,594,256(+) GCTGC(A/G)TTTGT upstream-variant-2KB
rs1000150141 -- 36,593,210(+) AAAGA(A/C)AAAAA upstream-variant-2KB
rs1000868272 -- 36,603,830(+) CTTAT(A/G)TGGGC nc-transcript-variant, utr-variant-3-prime
rs1000879456 -- 36,601,360(+) AAGTA(C/T)TTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF3 Gene

Variant ID Type Subtype PubMed ID
esv3608706 CNV loss 21293372
nsv1015689 CNV gain 25217958
nsv1131956 CNV deletion 24896259
nsv969391 CNV duplication 23825009

Variation tolerance for SRSF3 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF3 Gene

Disorders for SRSF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRSF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ocular hypertension
- elite association - COSMIC cancer census association via MalaCards
Search SRSF3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRSF3

Genetic Association Database (GAD)
SRSF3
Human Genome Epidemiology (HuGE) Navigator
SRSF3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF3
genes like me logo Genes that share disorders with SRSF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF3 Gene

Publications for SRSF3 Gene

  1. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PMID: 17036044) Hargous Y … Allain FH (The EMBO journal 2006) 3 4 22 60
  2. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. (PMID: 11336712) Huang Y … Steitz JA (Molecular cell 2001) 3 4 22 60
  3. SR proteins: a conserved family of pre-mRNA splicing factors. (PMID: 1577277) Zahler AM … Roth MB (Genes & development 1992) 2 3 4 60
  4. Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. (PMID: 26876937) Xiao W … Yang YG (Molecular cell 2016) 3 4 60
  5. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 60

Products for SRSF3 Gene

Sources for SRSF3 Gene

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