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Aliases for SRSF3 Gene

Aliases for SRSF3 Gene

  • Serine/Arginine-Rich Splicing Factor 3 2 3
  • Splicing Factor, Arginine/Serine-Rich 3 2 3 4
  • SRp20 3 4 6
  • SFRS3 3 4 6
  • Pre-MRNA-Splicing Factor SRP20 3 4
  • Splicing Factor, Arginine/Serine-Rich, 20-KD 3

External Ids for SRSF3 Gene

Previous Symbols for SRSF3 Gene

  • SFRS3

Summaries for SRSF3 Gene

Entrez Gene Summary for SRSF3 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF3 Gene

SRSF3 (Serine/Arginine-Rich Splicing Factor 3) is a Protein Coding gene. Diseases associated with SRSF3 include ocular hypertension. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and phospholipase binding. An important paralog of this gene is SRSF4.

UniProtKB/Swiss-Prot for SRSF3 Gene

  • May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

Gene Wiki entry for SRSF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF3 Gene

Genomics for SRSF3 Gene

Genomic Location for SRSF3 Gene

Start:
36,594,313 bp from pter
End:
36,605,600 bp from pter
Size:
11,288 bases
Orientation:
Plus strand

Genomic View for SRSF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF3 Gene

No data available for Regulatory Elements for SRSF3 Gene

Proteins for SRSF3 Gene

  • Protein details for SRSF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84103-SRSF3_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 3
    Protein Accession:
    P84103
    Secondary Accessions:
    • B4E241
    • O08831
    • P23152
    • Q5R3K0

    Protein attributes for SRSF3 Gene

    Size:
    164 amino acids
    Molecular mass:
    19330 Da
    Quaternary structure:
    • Interacts with CPSF6, RBMY1A1 and SREK1/SFRS12. Interacts with NXF1.

    Three dimensional structures from OCA and Proteopedia for SRSF3 Gene

    Alternative splice isoforms for SRSF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF3 Gene

Proteomics data for SRSF3 Gene at MOPED

Post-translational modifications for SRSF3 Gene

  • Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys23 and Lys85

Other Protein References for SRSF3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SRSF3 Gene

Domains for SRSF3 Gene

Gene Families for SRSF3 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SRSF3_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • P84103
Family:
  • Belongs to the splicing factor SR family.:
    • P84103
genes like me logo Genes that share domains with SRSF3: view

Function for SRSF3 Gene

Molecular function for SRSF3 Gene

UniProtKB/Swiss-Prot Function: May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.

Gene Ontology (GO) - Molecular Function for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 2030943
GO:0005515 protein binding IPI 14559993
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF3: view
genes like me logo Genes that share phenotypes with SRSF3: view

Animal Models for SRSF3 Gene

MGI Knock Outs for SRSF3:

miRNA for SRSF3 Gene

miRTarBase miRNAs that target SRSF3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRSF3 Gene

Localization for SRSF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF3 Gene COMPARTMENTS Subcellular localization image for SRSF3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SRSF3: view

Pathways for SRSF3 Gene

genes like me logo Genes that share pathways with SRSF3: view

Gene Ontology (GO) - Biological Process for SRSF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0008380 RNA splicing TAS --
genes like me logo Genes that share ontologies with SRSF3: view

Compounds for SRSF3 Gene

(2) Novoseek inferred chemical compound relationships for SRSF3 Gene

Compound -log(P) Hits PubMed IDs
serine 45.2 2
arginine 44.9 3
genes like me logo Genes that share compounds with SRSF3: view

Transcripts for SRSF3 Gene

Unigene Clusters for SRSF3 Gene

Serine/arginine-rich splicing factor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e ·
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - - - - -
SP5: - -
SP6: -
SP7: -
SP8: -
SP9: - - - - - - - - - - - - -
SP10: - - - - - -
SP11:
SP12: - -

ExUns: 13f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SRSF3 Gene

GeneLoc Exon Structure for
SRSF3
ECgene alternative splicing isoforms for
SRSF3

Expression for SRSF3 Gene

mRNA expression in normal human tissues for SRSF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF3 Gene

SOURCE GeneReport for Unigene cluster for SRSF3 Gene Hs.405144

genes like me logo Genes that share expressions with SRSF3: view

Orthologs for SRSF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF3 36
  • 99.59 (n)
  • 100 (a)
SRSF3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRSF3 36
  • 94.92 (n)
  • 100 (a)
SRSF3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF3 36
  • 94.72 (n)
  • 100 (a)
SRSF3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm12355 37
  • 96 (a)
OneToOne
Srsf3 36
  • 91.87 (n)
  • 100 (a)
Srsf3 16
oppossum
(Monodelphis domestica)
Mammalia SRSF3 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF3 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf3 36
  • 93.5 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SRSF3 36
  • 83.54 (n)
  • 100 (a)
SRSF3 37
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF3 37
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sfrs3-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf3 36
  • 80.28 (n)
  • 99.39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11030 36
zebrafish
(Danio rerio)
Actinopterygii sfrs3 36
srsf3a 37
  • 85 (a)
OneToMany
srsf3b 37
  • 94 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-6 37
  • 48 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9083 37
  • 58 (a)
OneToOne
Species with no ortholog for SRSF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF3 Gene

ENSEMBL:
Gene Tree for SRSF3 (if available)
TreeFam:
Gene Tree for SRSF3 (if available)

Paralogs for SRSF3 Gene

Paralogs for SRSF3 Gene

Selected SIMAP similar genes for SRSF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SRSF3: view

Variants for SRSF3 Gene

Sequence variations from dbSNP and Humsavar for SRSF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7344 -- 36,602,589(+) ATTGC(C/T)GTATA utr-variant-3-prime, nc-transcript-variant
rs474004 -- 36,596,377(+) CCCCA(A/C)CAGAA intron-variant
rs611831 -- 36,597,531(-) AGTAA(C/G)TGATT intron-variant
rs1062056 -- 36,603,276(+) GAATT(C/T)TAAGC utr-variant-3-prime, nc-transcript-variant
rs1062065 -- 36,603,306(+) AGTTC(A/C)CAATA utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF3 Gene

Variant ID Type Subtype PubMed ID
nsv885806 CNV Gain 21882294

Relevant External Links for SRSF3 Gene

HapMap Linkage Disequilibrium report
SRSF3

Disorders for SRSF3 Gene

(1) MalaCards Diseases for SRSF3 Gene

Search for SRSF3 Gene in MalaCards »

Relevant External Links for SRSF3

Genetic Association Database (GAD)
SRSF3
Human Genome Epidemiology (HuGE) Navigator
SRSF3
genes like me logo Genes that share disorders with SRSF3: view

No data available for UniProtKB/Swiss-Prot for SRSF3 Gene

Publications for SRSF3 Gene

  1. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. (PMID: 11336712) Huang Y. … Steitz J.A. (Mol. Cell 2001) 3 4 23
  2. SR proteins: a conserved family of pre-mRNA splicing factors. (PMID: 1577277) Zahler A.M. … Roth M.B. (Genes Dev. 1992) 2 3 4
  3. Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. (PMID: 17036044) Hargous Y. … Allain F.H. (EMBO J. 2006) 3 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. (PMID: 15169763) Dettwiler S. … Barabino S.M. (J. Biol. Chem. 2004) 3 4

Products for SRSF3 Gene

Sources for SRSF3 Gene

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