Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SRSF2 Gene

protein-coding GIFtS: 59
GCID: GC17M074731

serine/arginine-rich splicing factor 2

(Previous names: splicing factor, arginine/serine-rich 2 )
(Previous symbol: SFRS2)

Explore 26 diseases affiliated with
SRSF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 2¹ ²		SFRS2A¹ ²
SFRS2¹ ² ³ ⁵		Splicing Component, 35 KDa² ³
Splicing Factor, Arginine/Serine-Rich 2¹ ² ³		Splicing Factor SC35² ³
SC-35¹ ² ³		SRp30b²
PR264¹ ²		SR Splicing Factor 2²
SC35¹ ²		Protein PR264³

External Ids:	HGNC: 10783¹	Entrez Gene: 6427²	Ensembl: ENSG00000161547⁷	OMIM: 600813⁵	UniProtKB: Q01130³

ORGUL members:
	NONCODE:n410148

Export aliases for SRSF2 gene to outside databases

Previous GC identifer: GC17M070157

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF2:

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,

which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding

RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates

interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins

have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants

encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a

pseudogene of this gene has been found on chromosome 11. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: SRSF2_HUMAN, Q01130

Function: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing

complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome

assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with

other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding

components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or

5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by

SRPK2) is required for cellular apoptosis in response to cisplatin treatment

Gene Wiki entry for SRSF2 (SFRS2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SRSF2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRSF2 promoter sequence

Search SABiosciences Chromatin IP Primers for SRSF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.2

SRSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M074731: view genomic region (about GC identifiers)

Start:	74,730,197 bp from pter	End:	74,733,456 bp from pter
Size:	3,260 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRSF2_HUMAN, Q01130 (See protein sequence)

Recommended Name: Serine/arginine-rich splicing factor 2

Size: 221 amino acids; 25476 Da

Subunit: Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and

U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with

ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus)

Subcellular location: Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Note=Phosphorylation by SRPK2 provokes its

redistribution from the nuclear specke to nucleoplasm

4 PDB 3D structures from and Proteopedia for SRSF2:

2KN4 (3D)

2LEA (3D)

2LEB (3D)

2LEC (3D)

Secondary accessions: B3KWD5

Explore the universe of human proteins at neXtProt for SRSF2: NX_Q01130

Post-translational modifications:

Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its

redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin

treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation¹

Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6,

which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01130

SRSF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001182356.1 NP_003007.2

ENSEMBL proteins:

ENSP00000376276 ENSP00000353089 ENSP00000462425 ENSP00000391278 ENSP00000441780

ENSP00000463317 ENSP00000350877

Reactome Protein details: Q01130
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SRSF2 OriGene Custom Protein Services for SRSF2
	GenScript Custom Purified and Recombinant Proteins Services for SRSF2
	Novus Biologicals SRSF2 Protein Novus Biologicals SRSF2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SRSF2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005681	spliceosomal complex	IEA	--
GO:0016605	NOT PML body	IDA	15652350
GO:0016607	nuclear speck	IDA	15798186

SRSF2 for ontologies About GeneDecksing

SRSF2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF2
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SRSF2
	GenScript Custom Superior Antibodies Services for SRSF2
	Novus Biologicals SRSF2 Antibodies
	Search for Antibodies for SRSF2 at Abcam
	Uscn Antibodies for SRSF2
	ThermoFisher Antibodies for SRSF2

Assay Products for SRSF2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SRSF2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SRSF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SRSF2 for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry Q01130

ProtoNet protein and cluster: Q01130

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: SRSF2_HUMAN, Q01130

Similarity: Belongs to the splicing factor SR family

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SRSF2_HUMAN, Q01130

Function: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing

complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome

assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with

other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding

components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or

5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by

SRPK2) is required for cellular apoptosis in response to cisplatin treatment

Induction: Accumulates in a hypoacetylated/phosphorylated form in response to cisplatin treatment

miRNA Products:		miRTarBase miRNAs that target SRSF2: hsa-mir-183 (MIRT004741), hsa-mir-34c-5p (MIRT004405), hsa-mir-34b (MIRT004404)

		OriGene 3'-UTR Clone: SRSF2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF2
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF2 (see all 64):
		hsa-miR-576-3p hsa-miR-582-3p hsa-miR-4254 hsa-miR-193a-3p hsa-miR-134 hsa-miR-519a hsa-miR-1538 hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SRSF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF2 (see all 4) OriGene shRNA RFP: SRSF2 OriGene siRNA: SRSF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SRSF2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SRSF2 (NM_003016)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SRSF2
		Search LifeMap BioReagents cell lines for SRSF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003714	transcription corepressor activity	NAS	15652350
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	15652350

SRSF2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for SRSF2:

Decreased melanin production

Increased gamma-H2AX phosphory

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Srsf2^tm1.1Xdfu for SRSF2
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Srsf2):

cardiovascular system	cellular	hematopoietic system	immune system	mortality/aging
muscle

SRSF2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing	1.00	mRNA processing	0.48
mRNA Splicing - Major Pathway	1.00	mRNA Splicing - Minor Pathway	0.40
Processing of Capped Intron-Containing Pre-mRNA	0.96	Spliceosome	0.31
mRNA Processing	0.82

RNA Polymerase II Transcription Termination

RNA Polymerase II Transcription Termination	1.00	Post-Elongation Processing of Intron-Containing pre-mRNA	0.79
Post-Elongation Processing of the Transcript	1.00	mRNA 3'-end processing	0.79
Cleavage of Growing Transcript in the Termination Region	1.00

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

Transport of Mature Transcript to Cytoplasm

Transport of Mature Transcript to Cytoplasm

1.00

Transport of Mature mRNA derived from an Intron-Containing Transcript

0.85

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SRSF2

mRNA processing

5/15 Reactome Pathways for SRSF2 (see all 15)

	Transport of Mature mRNA derived from an Intron-Containing Transcript
	mRNA Splicing - Major Pathway
	Transport of Mature Transcript to Cytoplasm
	mRNA Splicing
	RNA Polymerase II Transcription

1 Kegg Pathway (Kegg details for SRSF2):

Spliceosome

SRSF2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SRSF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/660 Interacting proteins for SRSF2 (Q01130^{1, 2, 3} ENSP00000350877⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 660)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HNRNPM	P52272²^,³, ENSP00000325376⁴	MINT-7945693 MINT-7979432 I2D: score=1 STRING: ENSP00000325376
CIR1	Q86X95¹^,³, ENSP00000339723⁴	EBI-627047,EBI-627102 I2D: score=3 STRING: ENSP00000339723
SNRNP70	P08621²^,³, ENSP00000221448⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000221448
CDC5L	Q99459²^,³, ENSP00000360532⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000360532
HABP4	Q5JVS0²^,³, ENSP00000364398⁴	MINT-7041189 I2D: score=1 STRING: ENSP00000364398

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006369	termination of RNA polymerase II transcription	TAS	--
GO:0006397	mRNA processing	TAS	8530103
GO:0006406	mRNA export from nucleus	TAS	--

SRSF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SRSF2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SRSF2
10 Novoseek chemical compound relationships for SRSF2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
camptothecin	39	2	14597418 (1), 17709397 (1)
arginine	38	5	1454802 (1), 10022858 (1), 9685421 (1), 9108022 (1) (see all 5)
serine	37.9	5	11815617 (1), 10022858 (1), 9685421 (1), 12525645 (1) (see all 5)
uridine	19.4	1	8541878 (1)
zinc	11.6	1	9761791 (1)
adenylate	2.25	1	9056409 (1)
nacl	0	1	9044054 (1)
atp	0	2	16895966 (1), 1531875 (1)
steroid	0	2	11730918 (1), 11101696 (1)
tyrosine	0	1	11239462 (1)

Search CenterWatch for drugs/clinical trials and news about SRSF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SRSF2 gene (2 alternative transcripts):

NM_001195427.1 NM_003016.4

Unigene Cluster for SRSF2:

Serine/arginine-rich splicing factor 2

Hs.584801 [show with all ESTs]

Unigene Representative Sequence: NM_003016

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392485(uc010wtg.2 uc002jsv.3) ENST00000359995(uc002jsy.4)

ENST00000585202 ENST00000582449(uc002jsw.2) ENST00000586778 ENST00000452355

ENST00000589919 ENST00000508921 ENST00000592676 ENST00000583836 ENST00000358156

miRNA Products:		OriGene 3'-UTR Clone: SRSF2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF2
		8/64 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF2 (see all 64):
		hsa-miR-576-3p hsa-miR-582-3p hsa-miR-4254 hsa-miR-193a-3p hsa-miR-134 hsa-miR-519a hsa-miR-1538 hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SRSF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF2 (see all 4) OriGene shRNA RFP: SRSF2 OriGene siRNA: SRSF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SRSF2 (NM_003016)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SRSF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF2
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF2

Additional cDNA sequence:

AK092489.1 AK093626.1 AK097069.1 AK098209.1 AK123712.1 AK124792.1 AK126432.1 AK223252.1

AK297813.1 BC000339.2 BC001303.2 BC063570.1 BC066958.1 BC070086.1 BT007250.1 M90104.1

NR_036608.1 X62447.1

24/55 DOTS entries (see all 55):

DT.100674705 DT.100674715 DT.100039139 DT.87077676 DT.100775016 DT.100683898 DT.120925058 DT.120924939

DT.95126016 DT.92463589 DT.100674710 DT.100868084 DT.100674699 DT.100718826 DT.100674703 DT.100674709

DT.100674714 DT.120924957 DT.95126032 DT.100775015 DT.120924988 DT.100674720 DT.120924966 DT.120925069

24/1026 AceView cDNA sequences (see all 1026):

BI856341 CA438501 AI559538 AI766681 BX114122 AL039758 BU679685 AV661064

F09151 BI089954 BQ083738 AI570721 BU727002 AA919176 BE350619 BE883421

CB270609 BU678328 AW168223 BU684332 BG034279 AI635109 AA379390 T16412

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4
SP1:
SP2:											-		-
SP3:					-		-

ECgene alternative splicing isoforms for SRSF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SRSF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTATCTTT

About this image
See SRSF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRSF2

SOURCE GeneReport for Unigene cluster: Hs.584801

SABiosciences Custom PCR Arrays for SRSF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SRSF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF2
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRSF2 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SRSF2¹	serine/arginine-rich splicing factor 2	83.41(n) 98.19(a)		396195 NM_001001305.2 NP_001001305.1
lizard (Anolis carolinensis)	Reptilia	SRSF2⁶	--	99(a)	1 ↔ 1	2(111632781-111634785)
African clawed frog (Xenopus laevis)	Amphibia	BC045229.1²	--	78.94(n)		BC045229.1
zebrafish (Danio rerio)	Actinopterygii	Dr.8481²	Danio rerio mRNA similar to splicing factor, arginine/serine-rich more	80.78(n)		BC046045.1
fruit fly (Drosophila melanogaster)	Insecta	SC35⁶	SC35	54(a)	1 ↔ 1	2L(12431075-12434665)
worm (Caenorhabditis elegans)	Secernentea	rsp-4⁶	Probable splicing factor, arginine/serine-rich 4	45(a)	1 ↔ 1	II(5387402-5388813)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATSC35⁶	splicing factor, arginine/serine-rich 2	29(a)	1 ↔ 1	5(25681202-25683641)
rice (Oryza sativa)	Liliopsida	Os08g0486200¹	hypothetical protein	47.07(n) 55.28(a)		4345884 NM_001068629.1 NP_001062094.1

ENSEMBL Gene Tree for SRSF2 (if available)
TreeFam Gene Tree for SRSF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SRSF2 gene

LOC100996657² SRSF4² SRSF12² SRSF10² SRSF9² SRSF5² SRSF7² SRSF1²

SRSF6² SRSF3²

18/21 SIMAP similar genes for SRSF2 using alignment to 4 protein entries: SRSF2_HUMAN (see all proteins) (see all similar genes):

SFRS2 SRSF8 CIRBP RBMY1A1 LOC346472 HNRNPA1

RBM3 FUSIP1 PABPN1 SRSF12 RBMX CELF1

SRSF6 SRSF10 RNPS1 LOC392896 RBM38 DKFZp686F18120

SRSF2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SRSF2
PGOHUM00000263339

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs15184^1,2	H	--	70157463(-)	`TGCAAA/TGGAAA`	3	--	int¹		5	MN NS EA	586
rs12451240^1,2	C,F,H	--	70157847(+)	`TGCAGG/TCAGCC`	3	--	int¹		1	NA	4
rs62086783^1,2	C,F,	--	70157868(+)	`AATTGA/CATAGG`	3	--	int¹		4	NA EA	244
rs28693812^1,2	C,F,	--	70157903(+)	`AAGACC/TGAGAC`	3	--	int¹		2	WA EA	238
rs61742139^1,2	F	--	70160835(+)	`ACGTCG/TCCGAC`	5	G	syn¹		1	NS	78
rs17849462^1,2	C,F,	--	70160913(+)	`TTGAGG/AGAGGT`	5	/S	nc-transcript-variantsyn¹ ese³		1	NA	3242
rs9902379^1,2	C,F,	--	70161080(+)	`TGCCGC/TAGAAC`	3	--	nc-transcript-variantut5¹		1	WA	118
rs9902624^1,2	C,F,H,	--	70161224(+)	`CCGCGC/TCCCGC`	3	--	us2k¹		11	NS EA NA MN WA	1754
rs11652034^1,2	C,H	--	70161273(+)	`AGCGCC/TTGCGC`	3	--	us2k¹		1	NA	2
rs73996694^1,2	C,	--	70161892(+)	`GATAAA/GTTCTT`	3	--	us2k¹		2	WA	120

HapMap Linkage Disequilibrium report for SRSF2 (74730197 - 74733456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SRSF2: --

3 SABiosciences Cancer Mutation PCR Assays for SRSF2:

Cosmic Id	AA Change
98000029	P95L
98000030	P95R
98000028	P95H

1 SABiosciences Cancer Mutation PCR Array containing SRSF2:

Myelodysplastic Syndromes

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF2

DNA2.0 Custom Variant and Variant Library Synthesis for SRSF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SRSF2 for disorders           About GeneDecksing

OMIM gene information: 600813    OMIM disorders: --

20/26 diseases for SRSF2 (see all 26):    About MalaCards

holt-oram syndrome growth hormone deficiency amyotrophic neuralgia lactic acidosis

papillary renal carcinoma dilated cardiomyopathy acute myeloid leukemia retinitis pigmentosa

myeloid leukemia renal carcinoma bipolar disorder thymoma

neurofibromatosis cardiomyopathy hepatocellular carcinoma retinitis

immunodeficiency influenza leukemia carcinoma

1 disease from the University of Copenhagen DISEASES database for SRSF2:

Amyotrophic neuralgia

4 Novoseek disease relationships for SRSF2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	24.5	3	18550660 (1), 10022872 (1), 11090190 (1)
acidosis lactic	18.5	1	15798212 (1)
mental retardation	16.4	1	15798212 (1)
shock	0	2	16135820 (1), 12924631 (1)

Export disorders for SRSF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SRSF2 gene, integrated from 9 sources (see all 218):
(articles sorted by number of sources associating them with SRSF2)

Utopia: connect your pdf to the dynamic
world of online information

Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). (PubMed id 8530103)^{1, 3, 9} Bermingham J.R....Rosenfeld M.G. (1995)
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. (PubMed id 8261509)^{1, 2, 9} Wu J.Y. and Maniatis T. (1993)
Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. (PubMed id 14684736)^{1, 2, 9} Yang L.... Cao X. (2004)
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. (PubMed id 1373910)^{1, 2, 9} Fu X.-D. and Maniatis T. (1992)
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. (PubMed id 21157427)^{1, 2} Edmond V....Eymin B. (2011)
A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)^{1, 3} Manley J.L. and Krainer A.R. (2010)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6427	HGNC: 10783	AceView: SFRS2	Ensembl:ENSG00000161547	euGenes: HUgn6427
ECgene: SRSF2	Kegg: 6427	H-InvDB: SRSF2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SRSF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SRSF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SRSF2 gene:
Search GeneIP for patents involving SRSF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF2
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SRSF2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF2
	OriGene Protein Over-expression Lysate for SRSF2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SRSF2		OriGene 3'-UTR Clone for SRSF2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SRSF2		OriGene Custom Protein Services for SRSF2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRSF2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF2
	Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF2

	GenScript Custom Purified and Recombinant Proteins Services for SRSF2		GenScript cDNA clones with any tag delivered in your preferred vector for SRSF2
	GenScript Custom Assay Services for SRSF2		GenScript Custom Superior Antibodies Services for SRSF2
	GenScript Custom overexpressing Cell Line Services for SRSF2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for SRSF2
	Search Chromatin IP Primers for SRSF2
	RT² qPCR Primer Assay in human, mouse, rat SRSF2
	Search GNC Networks for SRSF2
	SABiosciences Custom PCR Arrays for SRSF2

Search Tocris compounds for SRSF2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SRSF2 antibodies
	SRSF2 proteins
	SRSF2 lysates

	Search for Antibodies for SRSF2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SRSF2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SRSF2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SRSF2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF2

	SwitchGear 3'UTR luciferase reporter plasmids for SRSF2
	SwitchGear Promoter luciferase reporter plasmids for SRSF2

ThermoFisher Antibodies for SRSF2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SRSF2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SRSF2 Gene

serine/arginine-rich splicing factor 2

Aliases
for SRSF2 gene

Summaries
for SRSF2 gene

Genomic Views
for SRSF2 gene

Proteins
for SRSF2 gene

Protein Domains /
Families
for SRSF2 gene

Function
for SRSF2 gene

Pathways & Interactions
for SRSF2 gene

Drugs & Compounds
for SRSF2 gene

Transcripts
for SRSF2 gene

Expression
for SRSF2 gene

Orthologs
for SRSF2 gene

Paralogs
for SRSF2 gene

Genomic Variants
for SRSF2 gene

Disorders / Diseases
for SRSF2 gene

Publications
for SRSF2 gene

External Searches for SRSF2 gene

Genome Databases showing SRSF2 gene

Other Databases showing SRSF2 gene

Specialized Databases showing SRSF2 gene

Intellectual Property
for SRSF2 gene

Products
for SRSF2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SRSF2 Gene

serine/arginine-rich splicing factor 2

Aliasesfor SRSF2 gene

Summariesfor SRSF2 gene

Genomic Viewsfor SRSF2 gene

Proteinsfor SRSF2 gene

Protein Domains /Familiesfor SRSF2 gene

Functionfor SRSF2 gene

Pathways & Interactionsfor SRSF2 gene

Drugs & Compoundsfor SRSF2 gene

Transcriptsfor SRSF2 gene

Expression for SRSF2 gene

Orthologsfor SRSF2 gene

Paralogsfor SRSF2 gene

Genomic Variantsfor SRSF2 gene

Disorders / Diseasesfor SRSF2 gene

Publicationsfor SRSF2 gene

External Searches for SRSF2 gene

Genome Databases showing SRSF2 gene

Other Databases showing SRSF2 gene

Specialized Databases showing SRSF2 gene

Intellectual Propertyfor SRSF2 gene

Productsfor SRSF2 gene

View Random Gene

Aliases
for SRSF2 gene

Summaries
for SRSF2 gene

Genomic Views
for SRSF2 gene

Proteins
for SRSF2 gene

Protein Domains /
Families
for SRSF2 gene

Function
for SRSF2 gene

Pathways & Interactions
for SRSF2 gene

Drugs & Compounds
for SRSF2 gene

Transcripts
for SRSF2 gene

Expression
for SRSF2 gene

Orthologs
for SRSF2 gene

Paralogs
for SRSF2 gene

Genomic Variants
for SRSF2 gene

Disorders / Diseases
for SRSF2 gene

Publications
for SRSF2 gene

Intellectual Property
for SRSF2 gene

Products
for SRSF2 gene