Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SRSF2 Gene

protein-coding   GIFtS: 59
GCID: GC17M074731

Serine/Arginine-Rich Splicing Factor 2

(Previous names: splicing factor, arginine/serine-rich 2)
(Previous symbol: SFRS2)
  See SRSF2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3.2

Aliases
Serine/Arginine-Rich Splicing Factor 21 2     SC-352 3
SFRS21 2 3 5     SC352 5
Splicing Factor, Arginine/Serine-Rich 21 2 3     PR2642
SR Splicing Factor 21 2     SFRS2A2
Splicing Component, 35 KDa2 3     SRp30b2
Splicing Factor SC352 3     Protein PR2643

External Ids:    HGNC: 107831   Entrez Gene: 64272   Ensembl: ENSG000001615477   OMIM: 6008135   UniProtKB: Q011303   
ORGUL members:    fRNAdb10:FR398778      
RNAdb15:EVF44138    

Export aliases for SRSF2 gene to outside databases

Previous GC identifer: GC17M070157


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SRSF2 Gene:
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors,
which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for
binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues
and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA
splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.
Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this
gene. In addition, a pseudogene of this gene has been found on chromosome 11. (provided by RefSeq, Sep 2010)

GeneCards Summary for SRSF2 Gene:
SRSF2 (serine/arginine-rich splicing factor 2) is a protein-coding gene. Diseases associated with SRSF2 include papillary renal carcinoma, and holt-oram syndrome. GO annotations related to this gene include RNA binding and transcription corepressor activity. An important paralog of this gene is LOC100996657.

UniProtKB/Swiss-Prot: SRSF2_HUMAN, Q01130
Function: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent
splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during
spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA.
Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice
site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G)
or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form
(by SRPK2) is required for cellular apoptosis in response to cisplatin treatment

Gene Wiki entry for SRSF2 (SFRS2) Gene

fRNAdb sequence ontology for SRSF2:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for SRSF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF2 promoter sequence
   Search Chromatin IP Primers for SRSF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

SRSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074731:  view genomic region     (about GC identifiers)

Start:
74,730,197 bp from pter      End:
74,733,493 bp from pter
Size:
3,297 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SRSF2_HUMAN, Q01130 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 2  
Size: 221 amino acids; 25476 Da
Subunit: Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70
and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts
with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus)
4 PDB 3D structures from and Proteopedia for SRSF2:
2KN4 (3D)        2LEA (3D)        2LEB (3D)        2LEC (3D)    
Secondary accessions: B3KWD5

Explore the universe of human proteins at neXtProt for SRSF2: NX_Q01130

Explore proteomics data for SRSF2 at MOPED

Post-translational modifications: 

  • Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its
    redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin
    treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation1
  • Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6,
    which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation1
  • Ubiquitination2 at Lys36
  • Modification sites at PhosphoSitePlus

  • See SRSF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182356.1  NP_003007.2  

    ENSEMBL proteins: 
     ENSP00000376276   ENSP00000353089   ENSP00000462425   ENSP00000391278   ENSP00000441780  
     ENSP00000463317   ENSP00000350877  
    Reactome Protein details: Q01130

    SRSF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SRSF2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SRSF2
    GenScript Custom Purified and Recombinant Proteins Services for SRSF2
    Novus Biologicals SRSF2 Protein
    Novus Biologicals SRSF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRSF2

     
    Search eBioscience for Proteins for SRSF2 

     
    antibodies-online proteins for SRSF2 (6 products) 

     
    antibodies-online peptides for SRSF2

    SRSF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRSF2
    Novus Biologicals SRSF2 Antibodies
    Search for Antibodies for SRSF2 at Abcam
    Cloud-Clone Corp. Antibodies for SRSF2
    ThermoFisher Antibodies for SRSF2
    antibodies-online antibodies for SRSF2 (19 products) 

    SRSF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRSF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRSF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRSF2
    Cloud-Clone Corp. CLIAs for SRSF2
    Search eBioscience for ELISAs for SRSF2 
    antibodies-online kits for SRSF2 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q01130

    ProtoNet protein and cluster: Q01130

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF2_HUMAN, Q01130
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SRSF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF2_HUMAN, Q01130
    Function: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent
    splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during
    spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA.
    Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice
    site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G)
    or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form
    (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment
    Induction: Accumulates in a hypoacetylated/phosphorylated form in response to cisplatin treatment

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003714transcription corepressor activity NAS15652350
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI15652350
         
    Find genes that share ontologies with SRSF2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for SRSF2:
     Decreased melanin production  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Srsf2):
     cardiovascular system  hematopoietic system  immune system  mortality/aging  muscle 

    Find genes that share phenotypes with SRSF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Srsf2tm1.1Xdfu for SRSF2

       genOway: Develop your customized and physiologically relevant rodent model for SRSF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRSF2:
    hsa-mir-183-5p (MIRT004741), hsa-let-7e-5p (MIRT051575), hsa-mir-34c-5p (MIRT004405), hsa-mir-34b-5p (MIRT004404), hsa-mir-155-5p (MIRT020895), hsa-let-7a-5p (MIRT052509), hsa-mir-130b-3p (MIRT020317), hsa-mir-93-5p (MIRT028143), hsa-mir-186-5p (MIRT045026)

    Block miRNA regulation of human, mouse, rat SRSF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF2 (see all 64):
    hsa-miR-576-3p hsa-miR-582-3p hsa-miR-4254 hsa-miR-193a-3p hsa-miR-134 hsa-miR-519a hsa-miR-1538 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRSF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SRSF2
    Predesigned siRNA for gene silencing in human, mouse, rat SRSF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRSF2

    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF2 (see all 6)
    OriGene ORF clones in mouse, rat for SRSF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF2 (NM_003016)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF2
    Addgene plasmids for SRSF2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRSF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SRSF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SRSF2_HUMAN, Q01130: Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Note=Phosphorylation by SRPK2 provokes its
    redistribution from the nuclear specke to nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15652350
    GO:0005654nucleoplasm TAS--
    GO:0016605NOT PML body IDA15652350
    GO:0016607nuclear speck IDA12799190

    Find genes that share ontologies with SRSF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SRSF2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA processing0.44
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA Splicing - Minor Pathway0.38
    mRNA Splicing0.78
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SRSF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF2
        mRNA processing

    5 Reactome Pathways for SRSF2
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region
    mRNA Splicing - Minor Pathway


    2 Kegg Pathways  (Kegg details for SRSF2):
        Spliceosome
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF2
    Interactions:

        Search GeneGlobe Interaction Network for SRSF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRSF2 (Q011301, 2, 3 ENSP000003508774) via UniProtKB, MINT, STRING, and/or I2D (see all 689)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIR1Q86X951, 3, ENSP000003397234EBI-627047,EBI-627102 I2D: score=3 STRING: ENSP00000339723
    FUSP356372, 3, ENSP000002541084MINT-7945693 I2D: score=3 STRING: ENSP00000254108
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 I2D: score=2 STRING: ENSP00000221448
    HDAC6Q9UBN72, 3, ENSP000003340614MINT-8143365 I2D: score=1 STRING: ENSP00000334061
    SF3A2Q154282, 3, ENSP000002214944MINT-5205764 I2D: score=1 STRING: ENSP00000221494
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS8530103
    GO:0006406mRNA export from nucleus TAS--

    Find genes that share ontologies with SRSF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF2

    10 Novoseek inferred chemical compound relationships for SRSF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    camptothecin 39 2 14597418 (1), 17709397 (1)
    arginine 38 5 1454802 (1), 10022858 (1), 9685421 (1), 9108022 (1) (see all 5)
    serine 37.9 5 11815617 (1), 10022858 (1), 9685421 (1), 12525645 (1) (see all 5)
    uridine 19.4 1 8541878 (1)
    zinc 11.6 1 9761791 (1)
    adenylate 2.25 1 9056409 (1)
    nacl 0 1 9044054 (1)
    atp 0 2 16895966 (1), 1531875 (1)
    steroid 0 2 11730918 (1), 11101696 (1)
    tyrosine 0 1 11239462 (1)



    Find genes that share compounds with SRSF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for SRSF2 gene (2 alternative transcripts): 
    NM_001195427.1  NM_003016.4  

    Unigene Cluster for SRSF2:

    Serine/arginine-rich splicing factor 2
    Hs.584801  [show with all ESTs]
    Unigene Representative Sequence: NM_003016
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392485(uc010wtg.2 uc002jsv.3) ENST00000359995(uc002jsy.4)
    ENST00000585202 ENST00000582449(uc002jsw.2) ENST00000586778 ENST00000452355
    ENST00000589919 ENST00000508921 ENST00000592676 ENST00000583836 ENST00000358156

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SRSF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF2 (see all 64):
    hsa-miR-576-3p hsa-miR-582-3p hsa-miR-4254 hsa-miR-193a-3p hsa-miR-134 hsa-miR-519a hsa-miR-1538 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRSF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SRSF2
    Predesigned siRNA for gene silencing in human, mouse, rat SRSF2
    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF2 (see all 6)
    OriGene ORF clones in mouse, rat for SRSF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF2 (NM_003016)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF2
    Addgene plasmids for SRSF2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF2
      QuantiTect SYBR Green Assays in human, mouse, rat SRSF2
      Search QuantiFast Probe-based Assays in human, mouse, rat SRSF2

    Additional mRNA sequence: 

    AK092489.1 AK093626.1 AK097069.1 AK098209.1 AK123712.1 AK124792.1 AK126432.1 AK223252.1 
    AK297813.1 BC000339.2 BC001303.2 BC063570.1 BC066958.1 BC070086.1 BT007250.1 M90104.1 
    NR_036608.1 X62447.1 

    Selected DOTS entries (see all 55):

    DT.100674705  DT.100674715  DT.100039139  DT.87077676  DT.100775016  DT.100683898  DT.120925058  DT.120924939 
    DT.95126016  DT.92463589  DT.100674710  DT.100868084  DT.100674699  DT.100718826  DT.100674703  DT.100674709 
    DT.100674714  DT.120924957  DT.95126032  DT.100775015  DT.120924988  DT.100674720  DT.120924966  DT.120925069 

    Selected AceView cDNA sequences (see all 1026):

    CR593478 CB241746 BQ030185 BE677317 AA527562 BQ014548 BI084185 AI147884 
    BU608163 CR623313 AI131154 CR603955 BG034279 BE677835 AW193934 AI363041 
    CA421945 C17671 D56606 AW105249 CR597972 AI097231 AW612933 BQ575140 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
    SP1:                                                
    SP2:                                -     -         
    SP3:              -     -                           


    ECgene alternative splicing isoforms for SRSF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SRSF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTATCTTT
    SRSF2 Expression
    About this image


    SRSF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    SRSF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584801
        Custom PCR Arrays for SRSF2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF2
    QuantiTect SYBR Green Assays in human, mouse, rat SRSF2
    Search QuantiFast Probe-based Assays in human, mouse, rat SRSF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SRSF2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf21 , 5 serine/arginine-rich splicing factor 21, 5 87.78(n)1
    100(a)1
      11 (81.49 cM)5
    203821  NM_011358.21  NP_035488.11 
     1168499015 
    chicken
    (Gallus gallus)
    Aves SRSF21 serine/arginine-rich splicing factor 2 83.41(n)
    98.19(a)
      396195  NM_001001305.3  NP_001001305.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    2(111632773-111634794)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC045229.12   -- 78.94(n)    BC045229.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.84812 Danio rerio mRNA similar to splicing factor, arginine/serine-rich more 80.78(n)    BC046045.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SC356
    SC35
    61(a)
    1 → many
    2L(12431075-12434665)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-46
    Protein RSP-4, isoform b (rsp-4) mRNA, complete cd...
    59(a)
    1 → many
    II(5387419-5388830) WBGene00004701


    ENSEMBL Gene Tree for SRSF2 (if available)
    TreeFam Gene Tree for SRSF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SRSF2 gene
    LOC1009966572  ENSG000002718852  SRSF122  SRSF102  
    18 SIMAP similar genes for SRSF2 using alignment to 3 protein entries:     SRSF2_HUMAN (see all proteins):
    SFRS2    SRSF8    LOC346472    RBMX    CIRBP    RBMY1A1
    RBM3    FUSIP1    PABPN1    CELF1    SRSF12    SRSF6
    LOC392896    RNPS1    SRSF10    RBM38    DKFZp686F18120    SRSF7

    Find genes that share paralogs with SRSF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SRSF2
    PGOHUM00000263339


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SRSF2 (see all 136)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112737481,2
    C--70163074(+) ATGTA-/AAGCACTTGG
    C
    /AGCACTTGGCA
    ACAGT
    3 -- us2k1 tfbs30--------
    rs1438841581,2
    C--75816449(+) CTGGTA/CATTTC 3 -- int10--------
    rs151841,2
    H--75816456(-) TGCAAA/TGGAAA 3 -- int15Minor allele frequency- T:0.00MN NS EA 586
    rs1473214921,2
    C,F--75816472(+) CAGTCT/CCTGAA 3 -- int11Minor allele frequency- C:0.00EU 593
    rs1832838711,2
    C--75816483(+) TTATAC/TCTACA 3 -- int11Minor allele frequency- T:0.00EU 593
    rs1400157191,2
    C--75816500(+) TCTGGA/GACAGT 3 -- int10--------
    rs2013886681,2
    C--75816508(+) AGTATC/TAATAC 3 -- int11Minor allele frequency- T:0.00EU 589
    rs1494363821,2
    --75816547(+) AGCAGA/CCCACT 3 -- int10--------
    rs1447672091,2
    C--75816577(+) GGTCTG/TAAGAT 3 -- int10--------
    rs1878122061,2
    --75816636(+) AACTCA/CTATGA 3 -- int10--------

    HapMap Linkage Disequilibrium report for SRSF2 (74730197 - 74733493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SRSF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833550CNV Loss17160897
    nsv908833CNV Loss21882294
    nsv828110CNV Gain20364138

    3 Site Specific Mutation Identification with PCR Assays for SRSF2:
    Cosmic IdAA Change
    98000029P95L
    98000030P95R
    98000028P95H
    1 Site Specific Cancer Mutation PCR Panel containing SRSF2:
    Myelodysplastic Syndromes
    SeqTarget long-range PCR primers for resequencing SRSF2
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600813OMIM information:   
    2 diseases for SRSF2:    
    About MalaCards
    papillary renal carcinoma    holt-oram syndrome


    Find genes that share disorders with SRSF2           About GenesLikeMe

    4 Novoseek inferred disease relationships for SRSF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 24.5 3 18550660 (1), 10022872 (1), 11090190 (1)
    acidosis lactic 18.5 1 15798212 (1)
    mental retardation 16.4 1 15798212 (1)
    shock 0 2 16135820 (1), 12924631 (1)


    Export disorders for SRSF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SRSF2 gene, integrated from 10 sources (see all 237):
    (articles sorted by number of sources associating them with SRSF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). (PubMed id 8530103)1, 3, 9 Bermingham J.R....Rosenfeld M.G. (Genomics 1995)
    2. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. (PubMed id 8261509)1, 2, 9 Wu J.Y. and Maniatis T. (Cell 1993)
    3. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. (PubMed id 14684736)1, 2, 9 Yang L.... Cao X. (J. Biol. Chem. 2004)
    4. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. (PubMed id 1373910)1, 2, 9 Fu X.-D. and Maniatis T. (Science 1992)
    5. Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. (PubMed id 21157427)1, 2 Edmond V.... Eymin B. (EMBO J. 2011)
    6. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6427 HGNC: 10783 AceView: SFRS2 Ensembl:ENSG00000161547 euGenes: HUgn6427
    ECgene: SRSF2 Kegg: 6427 H-InvDB: SRSF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SRSF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SRSF2 gene:
    Search GeneIP for patents involving SRSF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF2
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SRSF2  
     OriGene qPCR primer pairs and template standards for SRSF2   OriGene Protein Over-expression Lysate for SRSF2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SRSF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRSF2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SRSF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRSF2   OriGene Custom Protein Services for SRSF2  

     
     
     Block miRNA regulation of human, mouse, rat SRSF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SRSF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF2 Predesigned siRNA for gene silencing in human, mouse, rat SRSF2
     Search QuantiFast Probe-based Assays in human, mouse, rat SRSF2 QuantiTect SYBR Green Assays in human, mouse, rat SRSF2
     Custom PCR Arrays for SRSF2 Search Chromatin IP Primers for SRSF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF2  Search GeneGlobe Interaction Network for SRSF2
     Search Regulatory tfbs for SRSF2
     GenScript Custom Purified and Recombinant Proteins Services for SRSF2 GenScript cDNA clones with any tag delivered in your preferred vector for SRSF2
     GenScript Custom Assay Services for SRSF2 GenScript Custom overexpressing Cell Line Services for SRSF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SRSF2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SRSF2 antibodies
     SRSF2 proteins
     SRSF2 lysates
     Search for Antibodies for SRSF2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SRSF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SRSF2
     Antibodies for SRSF2
     ELISAs for SRSF2
     CLIAs for SRSF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for SRSF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF2
     SwitchGear 3'UTR luciferase reporter plasmids for SRSF2
     SwitchGear Promoter luciferase reporter plasmids for SRSF2
     ThermoFisher Antibodies for SRSF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF2
     Browse compounds at ApexBio
     Addgene plasmids for SRSF2
      Search eBioscience for proteins for SRSF2
      Search eBioscience for elisas for SRSF2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SRSF2
     antibodies-online antibodies for SRSF2 (19 products)
     antibodies-online kits for SRSF2 (9 products)
     antibodies-online peptides for SRSF2
     antibodies-online proteins for SRSF2 (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRSF2 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4