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Aliases for SRSF2 Gene

Subcategory (RNA class) for SRSF2 Gene

lncRNA

Aliases for SRSF2 Gene

  • Serine/Arginine-Rich Splicing Factor 2 2 3
  • Splicing Factor, Arginine/Serine-Rich 2 2 3 4
  • SFRS2 3 4 6
  • Splicing Component, 35 KDa 3 4
  • SR Splicing Factor 2 2 3
  • Splicing Factor SC35 3 4
  • SC-35 3 4
  • SC35 3 6
  • Protein PR264 4
  • SFRS2A 3
  • SRp30b 3
  • PR264 3

External Ids for SRSF2 Gene

ORGUL Members for SRSF2 Gene

Previous Symbols for SRSF2 Gene

  • SFRS2

Summaries for SRSF2 Gene

Entrez Gene Summary for SRSF2 Gene

  • The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF2 Gene

SRSF2 (Serine/Arginine-Rich Splicing Factor 2) is a Protein Coding gene, and belongs to lncRNA RNA class. Diseases associated with SRSF2 include holt-oram syndrome. Among its related pathways are Gene Expression and Influenza A. GO annotations related to this gene include RNA binding and transcription corepressor activity. An important paralog of this gene is SRSF10.

UniProtKB/Swiss-Prot for SRSF2 Gene

  • Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5- and 3-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5- and 3-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5-AGSAGAGTA-3 (S=C or G) or 5-GTTCGAGTA-3. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.

Gene Wiki entry for SRSF2 Gene

fRNAdb sequence ontologies for SRSF2 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for SRSF2

No data available for Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for SRSF2 Gene

Genomics for SRSF2 Gene

Genomic Location for SRSF2 Gene

Start:
76,734,115 bp from pter
End:
76,737,411 bp from pter
Size:
3,297 bases
Orientation:
Minus strand

Genomic View for SRSF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF2 Gene

ORGUL Member Location for SRSF2 Gene

ORGUL Member Location for SRSF2 gene

No data available for Regulatory Elements for SRSF2 Gene

Proteins for SRSF2 Gene

  • Protein details for SRSF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01130-SRSF2_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 2
    Protein Accession:
    Q01130
    Secondary Accessions:
    • B3KWD5
    • B4DN89
    • H0YG49

    Protein attributes for SRSF2 Gene

    Size:
    221 amino acids
    Molecular mass:
    25476 Da
    Quaternary structure:
    • Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for SRSF2 Gene

    Alternative splice isoforms for SRSF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF2 Gene

Proteomics data for SRSF2 Gene at MOPED

Post-translational modifications for SRSF2 Gene

  • Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation.
  • Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys36

Other Protein References for SRSF2 Gene

No data available for DME Specific Peptides for SRSF2 Gene

Domains for SRSF2 Gene

Gene Families for SRSF2 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF2 Gene

UniProtKB/Swiss-Prot:

SRSF2_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q01130
Family:
  • Belongs to the splicing factor SR family.:
    • Q01130
genes like me logo Genes that share domains with SRSF2: view

Function for SRSF2 Gene

Molecular function for SRSF2 Gene

UniProtKB/Swiss-Prot Function: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5- and 3-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5- and 3-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5-AGSAGAGTA-3 (S=C or G) or 5-GTTCGAGTA-3. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
UniProtKB/Swiss-Prot Induction: Accumulates in a hypoacetylated/phosphorylated form in response to cisplatin treatment

Gene Ontology (GO) - Molecular Function for SRSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003714 transcription corepressor activity NAS 15652350
GO:0005515 protein binding IPI 15652350
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF2: view
genes like me logo Genes that share phenotypes with SRSF2: view

Animal Models for SRSF2 Gene

MGI Knock Outs for SRSF2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRSF2 Gene

Localization for SRSF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF2 Gene

Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF2 Gene COMPARTMENTS Subcellular localization image for SRSF2 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SRSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IDA --
GO:0016605 NOT PML body IDA 15652350
genes like me logo Genes that share ontologies with SRSF2: view

Pathways for SRSF2 Gene

genes like me logo Genes that share pathways with SRSF2: view

Gene Ontology (GO) - Biological Process for SRSF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing TAS 8530103
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF2: view

Compounds for SRSF2 Gene

(10) Novoseek inferred chemical compound relationships for SRSF2 Gene

Compound -log(P) Hits PubMed IDs
camptothecin 39 2
arginine 38 5
serine 37.9 5
uridine 19.4 1
zinc 11.6 1
genes like me logo Genes that share compounds with SRSF2: view

Transcripts for SRSF2 Gene

fRNAdb Secondary structures for SRSF2 Gene

  • FR398778

Unigene Clusters for SRSF2 Gene

Serine/arginine-rich splicing factor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4
SP1:
SP2: - -
SP3: - -

Relevant External Links for SRSF2 Gene

GeneLoc Exon Structure for
SRSF2
ECgene alternative splicing isoforms for
SRSF2

Expression for SRSF2 Gene

mRNA expression in normal human tissues for SRSF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF2 Gene

SOURCE GeneReport for Unigene cluster for SRSF2 Gene Hs.584801

genes like me logo Genes that share expressions with SRSF2: view

Orthologs for SRSF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF2 36
  • 99.25 (n)
  • 99.1 (a)
SRSF2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRSF2 36
  • 92.01 (n)
  • 100 (a)
SRSF2 37
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 100 (a)
OneToMany
SRSF2 36
  • 90.95 (n)
  • 99.55 (a)
mouse
(Mus musculus)
Mammalia Srsf2 36
  • 87.78 (n)
  • 100 (a)
Srsf2 16
Srsf2 37
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Srsf2 36
  • 90.05 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves SRSF2 36
  • 83.41 (n)
  • 98.19 (a)
SRSF2 37
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75633 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3833 36
zebrafish
(Danio rerio)
Actinopterygii Dr.8481 36
srsf2a 37
  • 83 (a)
ManyToMany
srsf2b 37
  • 80 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta SC35 37
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 37
  • 59 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3433 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11125 37
  • 70 (a)
OneToMany
Species with no ortholog for SRSF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF2 Gene

ENSEMBL:
Gene Tree for SRSF2 (if available)
TreeFam:
Gene Tree for SRSF2 (if available)

Paralogs for SRSF2 Gene

Paralogs for SRSF2 Gene

Pseudogenes.org Pseudogenes for SRSF2 Gene

genes like me logo Genes that share paralogs with SRSF2: view

Variants for SRSF2 Gene

Sequence variations from dbSNP and Humsavar for SRSF2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13588 -- 76,734,504(-) GCAGT(A/G)CAGAG utr-variant-3-prime, nc-transcript-variant
rs11550964 -- 76,734,393(+) ACTGG(A/G)AGTGC utr-variant-3-prime, nc-transcript-variant
rs533202486 -- 76,734,451(+) ACAAG(A/G)CATCT utr-variant-3-prime, nc-transcript-variant
rs542035458 -- 76,734,450(+) GACAA(A/G)GCATC utr-variant-3-prime, nc-transcript-variant
rs547395426 -- 76,734,453(+) AAGGC(A/G)TCTTT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF2 Gene

Variant ID Type Subtype PubMed ID
nsv908833 CNV Loss 21882294
nsv833550 CNV Loss 17160897
nsv828110 CNV Gain 20364138

Relevant External Links for SRSF2 Gene

HapMap Linkage Disequilibrium report
SRSF2

Disorders for SRSF2 Gene

(1) MalaCards Diseases for SRSF2 Gene

Search for SRSF2 Gene in MalaCards »

(4) Novoseek inferred disease relationships for SRSF2 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 24.5 3
acidosis lactic 18.5 1
mental retardation 16.4 1
shock 0 2
genes like me logo Genes that share disorders with SRSF2: view

No data available for UniProtKB/Swiss-Prot for SRSF2 Gene

Publications for SRSF2 Gene

  1. Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. (PMID: 1373910) Fu X.-D. … Maniatis T. (Science 1992) 3 4 23
  2. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. (PMID: 8261509) Wu J.Y. … Maniatis T. (Cell 1993) 3 4 23
  3. Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). (PMID: 8530103) Bermingham J.R. … Rosenfeld M.G. (Genomics 1995) 2 3 23
  4. Immunolabelling of spliceosomes in sections and cultured astrocytes of human fetal brain tissue. (PMID: 10082253) Ulfig N. … Briese V. (Brain Dev. 1999) 3 23
  5. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. (PMID: 9774382) Yang L. … Hickstein D.D. (J. Biol. Chem. 1998) 3 23

Products for SRSF2 Gene

  • Addgene plasmids for SRSF2

Sources for SRSF2 Gene

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