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Aliases for SRSF12 Gene

Aliases for SRSF12 Gene

  • Serine And Arginine Rich Splicing Factor 12 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 13B 2 3 4
  • Splicing Factor, Arginine/Serine-Rich 19 2 3 4
  • Serine/Arginine-Rich Splicing Factor 12 2 3
  • 35 KDa SR Repressor Protein 3 4
  • SR Splicing Factor 12 2 3
  • SFRS13B 3 4
  • SFRS19 3 4
  • SRrp35 3 4
  • Serine-Arginine Repressor Protein (35 KDa) 3

External Ids for SRSF12 Gene

Previous HGNC Symbols for SRSF12 Gene

  • SFRS13B

Previous GeneCards Identifiers for SRSF12 Gene

  • GC06M089805
  • GC06M087021

Summaries for SRSF12 Gene

GeneCards Summary for SRSF12 Gene

SRSF12 (Serine And Arginine Rich Splicing Factor 12) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF10.

UniProtKB/Swiss-Prot for SRSF12 Gene

  • Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.

Additional gene information for SRSF12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF12 Gene

Genomics for SRSF12 Gene

GeneHancer (GH) Regulatory Elements for SRSF12 Gene

Promoters and enhancers for SRSF12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I089117 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 561.6 +0.3 280 1.2 CTCF MXI1 ZIC2 ZNF48 ZNF335 ZNF121 FOXM1 GLIS2 POLR2A PATZ1 SRSF12 CASP8AP2 PM20D2 RNGTT GABRR1
GH06I089078 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 19 +36.7 36706 5.7 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 ENSG00000271931 PNRC1 SRSF12 CASP8AP2 PM20D2 UBE2J1 GC06P089091
GH06I089345 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.3 -232.2 -232175 8.6 HDGF PKNOX1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 SLC30A9 POLR2B UBE2J1 CASP8AP2 SRSF12 RRAGD GABRR2 TUBB3P1 MDN1 PNRC1 ANKRD6 RNGTT
GH06I089145 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.3 -28.4 -28412 2.8 PKNOX1 SMAD1 ARNT ZFP64 SIN3A DMAP1 ZNF48 SLC30A9 ZNF121 GLIS2 LOC101929004 PM20D2 SRSF12 GABRR2 ANKRD6
GH06I089072 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.3 +45.0 44992 1.8 ATF1 FOXA2 ARNT TCF12 GATA2 ATF7 NCOA1 MIER2 MEF2D NFIL3 SRSF12 GABRR1 PNRC1 RNU2-61P GC06M089064 ENSG00000271931
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SRSF12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SRSF12 Gene

Genomic Locations for SRSF12 Gene
chr6:89,095,957-89,118,081
(GRCh38/hg38)
Size:
22,125 bases
Orientation:
Minus strand
chr6:89,805,678-89,827,800
(GRCh37/hg19)

Genomic View for SRSF12 Gene

Genes around SRSF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF12 Gene

Proteins for SRSF12 Gene

  • Protein details for SRSF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF0-SRS12_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 12
    Protein Accession:
    Q8WXF0
    Secondary Accessions:
    • B2RA22
    • Q5T7K0
    • Q8WW25

    Protein attributes for SRSF12 Gene

    Size:
    261 amino acids
    Molecular mass:
    30512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI16247.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW48561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SRSF12 Gene

Post-translational modifications for SRSF12 Gene

No Post-translational modifications

Other Protein References for SRSF12 Gene

No data available for DME Specific Peptides for SRSF12 Gene

Domains & Families for SRSF12 Gene

Gene Families for SRSF12 Gene

Protein Domains for SRSF12 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXF0

UniProtKB/Swiss-Prot:

SRS12_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF12: view

Function for SRSF12 Gene

Molecular function for SRSF12 Gene

UniProtKB/Swiss-Prot Function:
Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.

Phenotypes From GWAS Catalog for SRSF12 Gene

Gene Ontology (GO) - Molecular Function for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 11684676
GO:0050733 RS domain binding NAS 11684676
GO:0051082 unfolded protein binding NAS 11684676
genes like me logo Genes that share ontologies with SRSF12: view

Phenotypes for SRSF12 Gene

GenomeRNAi human phenotypes for SRSF12:
genes like me logo Genes that share phenotypes with SRSF12: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF12 Gene

Localization for SRSF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF12 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm ISS 11684676
genes like me logo Genes that share ontologies with SRSF12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SRSF12 Gene

Pathways & Interactions for SRSF12 Gene

SuperPathways for SRSF12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 11684676
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 11684676
GO:0000395 mRNA 5-splice site recognition IDA 11684676
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SRSF12: view

No data available for Pathways by source and SIGNOR curated interactions for SRSF12 Gene

Drugs & Compounds for SRSF12 Gene

No Compound Related Data Available

Transcripts for SRSF12 Gene

Unigene Clusters for SRSF12 Gene

Serine/arginine-rich splicing factor 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for SRSF12 Gene

GeneLoc Exon Structure for
SRSF12
ECgene alternative splicing isoforms for
SRSF12

Expression for SRSF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF12 Gene

mRNA differential expression in normal tissues according to GTEx for SRSF12 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for SRSF12 Gene

This gene is overexpressed in Fetal Brain (36.9), Testis (13.2), and Fetal ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF12 Gene



Protein tissue co-expression partners for SRSF12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF12 Gene:

SRSF12

SOURCE GeneReport for Unigene cluster for SRSF12 Gene:

Hs.254414

mRNA Expression by UniProt/SwissProt for SRSF12 Gene:

Q8WXF0-SRS12_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with SRSF12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF12 Gene

Orthologs for SRSF12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF12 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia SRSF12 33 34
  • 94.51 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF12 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf12 33
  • 84.93 (n)
dog
(Canis familiaris)
Mammalia SRSF12 34
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf12 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf12 33
  • 74.63 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9386 33
fruit fly
(Drosophila melanogaster)
Insecta SC35 34
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4661 34
  • 46 (a)
OneToMany
Species where no ortholog for SRSF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SRSF12 Gene

ENSEMBL:
Gene Tree for SRSF12 (if available)
TreeFam:
Gene Tree for SRSF12 (if available)

Paralogs for SRSF12 Gene

Paralogs for SRSF12 Gene

(12) SIMAP similar genes for SRSF12 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SRSF12 Gene

genes like me logo Genes that share paralogs with SRSF12: view

Variants for SRSF12 Gene

Sequence variations from dbSNP and Humsavar for SRSF12 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000106183 -- 89,115,385(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000507272 -- 89,105,718(-) T/G intron_variant
rs1000613820 -- 89,106,262(-) G/A intron_variant
rs1000833986 -- 89,117,563(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001155068 -- 89,116,487(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF12 Gene

Variant ID Type Subtype PubMed ID
nsv1023532 CNV loss 25217958
nsv1027007 CNV gain 25217958

Variation tolerance for SRSF12 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SRSF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF12 Gene

Disorders for SRSF12 Gene

Additional Disease Information for SRSF12

No disorders were found for SRSF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF12 Gene

Publications for SRSF12 Gene

  1. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PMID: 11684676) Cowper AE … Screaton GR (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for SRSF12 Gene

Sources for SRSF12 Gene

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