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Aliases for SRSF12 Gene

Aliases for SRSF12 Gene

  • Serine And Arginine Rich Splicing Factor 12 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 13B 2 3 4
  • Splicing Factor, Arginine/Serine-Rich 19 2 3 4
  • Serine/Arginine-Rich Splicing Factor 12 2 3
  • 35 KDa SR Repressor Protein 3 4
  • SR Splicing Factor 12 2 3
  • SFRS13B 3 4
  • SFRS19 3 4
  • SRrp35 3 4
  • Serine-Arginine Repressor Protein (35 KDa) 3

External Ids for SRSF12 Gene

Previous HGNC Symbols for SRSF12 Gene

  • SFRS13B

Previous GeneCards Identifiers for SRSF12 Gene

  • GC06M089805
  • GC06M087021

Summaries for SRSF12 Gene

GeneCards Summary for SRSF12 Gene

SRSF12 (Serine And Arginine Rich Splicing Factor 12) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF10.

UniProtKB/Swiss-Prot for SRSF12 Gene

  • Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF12 Gene

Genomics for SRSF12 Gene

Regulatory Elements for SRSF12 Gene

Enhancers for SRSF12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F089140 0.9 ENCODE 27.4 -22.4 -22396 0.1 ELF3 TBP ZFP64 ARID4B DMAP1 THRB ZSCAN9 RARA SLC30A9 CREM SRSF12 LOC101929004
GH06F089345 1.5 FANTOM5 ENCODE 15.3 -232.2 -232175 8.6 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 NFYC CASP8AP2 UBE2J1 SRSF12 RRAGD GABRR2 TUBB3P1 PNRC1 RNGTT GABRR1 GC06M089320
GH06F089078 1.2 ENCODE 19 +36.7 36723 5.6 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CASP8AP2 SRSF12 LOC100131124 ENSG00000220130 ENSG00000222145 GJA10 ENSG00000232532 LOC644269 PM20D2 UBE2J1
GH06F089072 1.2 Ensembl ENCODE 17.3 +44.9 44893 2.0 HDAC1 CBX3 ATF1 TBL1XR1 YY1 ZNF766 GATA2 CREM ZNF680 ZBTB2 SRSF12 GABRR1 PNRC1 GC06M089064 ENSG00000271931 RNU2-61P
GH06F089033 1.7 FANTOM5 Ensembl ENCODE 10.7 +82.3 82303 4.5 PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 BRCA1 YY1 FOS PNRC1 CASP8AP2 SRSF12 RNGTT UBE2J1 RRAGD GC06M089046 PIR60881
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRSF12 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001222055 281 1600 CTCF ZNF792 SUZ12 ZMYM3 ZNF48 ZIC2 RARA ZNF121 ZNF664 GLIS2

Genomic Location for SRSF12 Gene

Chromosome:
6
Start:
89,095,957 bp from pter
End:
89,118,081 bp from pter
Size:
22,125 bases
Orientation:
Minus strand

Genomic View for SRSF12 Gene

Genes around SRSF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF12 Gene

Proteins for SRSF12 Gene

  • Protein details for SRSF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF0-SRS12_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 12
    Protein Accession:
    Q8WXF0
    Secondary Accessions:
    • B2RA22
    • Q5T7K0
    • Q8WW25

    Protein attributes for SRSF12 Gene

    Size:
    261 amino acids
    Molecular mass:
    30512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI16247.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW48561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SRSF12 Gene

Post-translational modifications for SRSF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRSF12 Gene

No data available for DME Specific Peptides for SRSF12 Gene

Domains & Families for SRSF12 Gene

Protein Domains for SRSF12 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXF0

UniProtKB/Swiss-Prot:

SRS12_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF12: view

Function for SRSF12 Gene

Molecular function for SRSF12 Gene

UniProtKB/Swiss-Prot Function:
Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.

Gene Ontology (GO) - Molecular Function for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding NAS 11684676
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0050733 RS domain binding NAS 11684676
genes like me logo Genes that share ontologies with SRSF12: view

Phenotypes for SRSF12 Gene

GenomeRNAi human phenotypes for SRSF12:
genes like me logo Genes that share phenotypes with SRSF12: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF12 Gene

Localization for SRSF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF12 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm ISS 11684676
genes like me logo Genes that share ontologies with SRSF12: view

Pathways & Interactions for SRSF12 Gene

SuperPathways for SRSF12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 11684676
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 11684676
GO:0000395 mRNA 5-splice site recognition IDA 11684676
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SRSF12: view

No data available for Pathways by source and SIGNOR curated interactions for SRSF12 Gene

Transcripts for SRSF12 Gene

Unigene Clusters for SRSF12 Gene

Serine/arginine-rich splicing factor 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for SRSF12 Gene

GeneLoc Exon Structure for
SRSF12
ECgene alternative splicing isoforms for
SRSF12

Expression for SRSF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRSF12 Gene

mRNA differential expression in normal tissues according to GTEx for SRSF12 Gene

This gene is overexpressed in Testis (x6.5).

Protein differential expression in normal tissues from HIPED for SRSF12 Gene

This gene is overexpressed in Fetal Brain (36.9), Testis (13.2), and Fetal ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF12 Gene



Protein tissue co-expression partners for SRSF12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF12 Gene:

SRSF12

SOURCE GeneReport for Unigene cluster for SRSF12 Gene:

Hs.254414

mRNA Expression by UniProt/SwissProt for SRSF12 Gene:

Q8WXF0-SRS12_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with SRSF12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SRSF12 Gene

Orthologs for SRSF12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF12 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia SRSF12 34 35
  • 94.51 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF12 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf12 34
  • 84.93 (n)
dog
(Canis familiaris)
Mammalia SRSF12 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf12 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf12 34
  • 74.63 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9386 34
fruit fly
(Drosophila melanogaster)
Insecta SC35 35
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4661 35
  • 46 (a)
OneToMany
Species where no ortholog for SRSF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SRSF12 Gene

ENSEMBL:
Gene Tree for SRSF12 (if available)
TreeFam:
Gene Tree for SRSF12 (if available)

Paralogs for SRSF12 Gene

Paralogs for SRSF12 Gene

(12) SIMAP similar genes for SRSF12 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SRSF12 Gene

genes like me logo Genes that share paralogs with SRSF12: view

Variants for SRSF12 Gene

Sequence variations from dbSNP and Humsavar for SRSF12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10455164 -- 89,103,749(+) GCCAC(C/T)GCACC intron-variant
rs10455502 -- 89,099,604(+) GATCT(C/T)AGCTC intron-variant
rs1054973 -- 89,096,169(-) AGAAA(A/G)AAATG upstream-variant-2KB, utr-variant-3-prime
rs10641766 -- 89,102,748(+) TATTT(-/ATTT)GTTGT intron-variant
rs10944430 -- 89,104,297(+) AATGG(C/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF12 Gene

Variant ID Type Subtype PubMed ID
nsv1023532 CNV loss 25217958
nsv1027007 CNV gain 25217958

Variation tolerance for SRSF12 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF12 Gene

Disorders for SRSF12 Gene

Relevant External Links for SRSF12

Genetic Association Database (GAD)
SRSF12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF12

No disorders were found for SRSF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF12 Gene

Publications for SRSF12 Gene

  1. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PMID: 11684676) Cowper A.E. … Screaton G.R. (J. Biol. Chem. 2001) 2 3 4 22 64
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for SRSF12 Gene

Sources for SRSF12 Gene

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