SRSF12 Gene
protein-coding GIFtS: 45
GCID: GC06M089805
|
|
serine/arginine-rich splicing factor 12(Previous names: splicing factor, arginine/serine-rich 13B )
(Previous symbol: SFRS13B)
| |
Aliases
for SRSF12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Arginine-Rich Splicing Factor 121 2 | | 35 KDa SR Repressor Protein2 3 | | Splicing Factor, Arginine/Serine-Rich 13B1 2 3 | | RP11-63L7.32 | | SFRS13B1 2 3 | | Serine-Arginine Repressor Protein (35 KDa)2 | | SFRS191 2 3 | | SR Splicing Factor 122 | | SRrp351 2 3 | | SRRP353 | | Splicing Factor, Arginine/Serine-Rich 192 3 | | |
Export aliases for SRSF12 gene to outside databasesPrevious GC identifer: GC06M087021 |
Summaries
for SRSF12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0Function: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation
|
Genomic Views
for SRSF12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007299.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SRSF12
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRSF12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q16.1SRSF12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M089805: view genomic region
(about GC identifiers)
Start:
|
89,805,678 bp from pter |
End:
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89,827,800 bp from pter |
Size:
|
22,123 bases |
Orientation:
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minus strand |
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Proteins
for SRSF12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0 (See
protein sequence)Recommended Name: Serine/arginine-rich splicing factor 12 Size: 261 amino acids; 30512 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=CAI16247.1; Type=Erroneous gene model prediction; Sequence=EAW48561.1; Type=Erroneous genemodel prediction;
Secondary accessions: B2RA22 Q5T7K0 Q8WW25Explore the universe of human proteins at neXtProt for SRSF12: NX_Q8WXF0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXF0
SRSF12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542781.3
ENSEMBL proteins: ENSP00000414302 ENSP00000430513 ENSP00000427982
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
SRSF12 for ontologies About GeneDecksing
SRSF12 Antibody Products:
Assay Products for SRSF12: |
Protein
Domains /
Families
for SRSF12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRSF12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXF0ProtoNet protein and cluster: Q8WXF0 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0Similarity: Belongs to the splicing factor SR familySimilarity: Contains 1 RRM (RNA recognition motif) domain |
Function
for SRSF12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0Function: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRSF12 (NM_080743) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRSF12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF12 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
SRSF12 for ontologies About GeneDecksing
|
Pathways & Interactions
for SRSF12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF12
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SRSF12 (ENSP000004143024) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
SRSF12 for ontologies About GeneDecksing
|
Drugs & Compounds
for SRSF12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRSF12
Search CenterWatch for drugs/clinical trials and news about SRSF12 / SRS12
|
Transcripts
for SRSF12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRSF12 gene: NM_080743.4 Unigene Cluster for SRSF12: Serine/arginine-rich splicing factor 12 Hs.254414 [show with all ESTs]Unigene Representative Sequence: NM_0807435 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452027(uc021zcq.1) ENST00000524221 ENST00000488604 ENST00000475068
ENST00000517387
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRSF12 (NM_080743) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRSF12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF12 |
Additional cDNA sequence: AF449428.1 AK090803.1 AK123215.1 AK314008.1 BC021715.1 5 DOTS entries: DT.86841496 DT.92417336 DT.101977177 DT.431523 DT.97805846 24/28 AceView cDNA sequences (see all 28): AF449428 BP362656 AK090803 AA972419 AI206456 AK123215 AA889416 BI460898 AI632614 BE502279 BG722510 AI808562 BC021715 BX105734 NM_080743 AW043659 BU852922 BX472788 BG718755 AI638470 BM721805 BG701008 AI077367 CD359161
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF12 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SRSF12
|
Expression
for SRSF12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRSF12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTAGAAAGA
About this image
See SRSF12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRSF12
SOURCE GeneReport for Unigene cluster: Hs.254414
UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for SRSF12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SRSF12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF12 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF12 |
Orthologs
for SRSF12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SRSF12 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for SRSF12 (if available)
TreeFam Gene Tree for SRSF12 (if available) |
Paralogs
for SRSF12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRSF12 gene
- LOC1009966572 SRSF42 SRSF102 SRSF92 SRSF52 SRSF22 SRSF72 SRSF12
- SRSF62 SRSF32
15 SIMAP similar genes for SRSF12 using alignment to 3 protein entries: SRS12_HUMAN (see all proteins):SRrp35 FUSIP1 SRSF10 SFRS2 SFRS3 SRSF2
SRSF3 SFRS5 SRSF7 SRSF8 P14 SF3B14
HNRNPA1 LOC346472 LOC392896
SRSF12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SRSF12
PGOHUM00000248183
|
Genomic Variants
for SRSF12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRSF12 (89805678 - 89827800 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SRSF12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF12 |
|
Disorders
/ Diseases
for SRSF12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRSF12 for disorders About GeneDecksing
1  disease for SRSF12: About MalaCardsmalaria
Export disorders for SRSF12 gene to outside databases
|
Publications
for SRSF12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRSF12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SRSF12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PubMed id 11684676)1, 2, 3, 9 Cowper A.E.... Screaton G.R. (2001)
- A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SRSF12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRSF12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRSF12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRSF12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRSF12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRSF12 gene:
Search GeneIP for patents involving SRSF12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRSF12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SRSF12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF12 | | | OriGene Protein Over-expression Lysate for SRSF12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRSF12 | | OriGene 3'-UTR Clone for SRSF12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SRSF12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SRSF12 | | OriGene Custom Protein Services for SRSF12 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRSF12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF12 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF12 |
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 |  |  |  | |
| | | | Search Tocris compounds for SRSF12 |
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 | | | SRSF12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF12 |
|  |  |  | | | | ThermoFisher Antibodies for SRSF12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF12 |
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