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Aliases for SRSF12 Gene

Aliases for SRSF12 Gene

  • Serine/Arginine-Rich Splicing Factor 12 2 3
  • Splicing Factor, Arginine/Serine-Rich 13B 2 3 4
  • Splicing Factor, Arginine/Serine-Rich 19 3 4
  • 35 KDa SR Repressor Protein 3 4
  • SR Splicing Factor 12 2 3
  • SFRS13B 3 4
  • SFRS19 3 4
  • SRrp35 3 4
  • Serine-Arginine Repressor Protein (35 KDa) 3
  • Arginine/Serine-Rich 19 2
  • Splicing Factor 2

External Ids for SRSF12 Gene

Previous Symbols for SRSF12 Gene

  • SFRS13B

Summaries for SRSF12 Gene

GeneCards Summary for SRSF12 Gene

SRSF12 (Serine/Arginine-Rich Splicing Factor 12) is a Protein Coding gene. GO annotations related to this gene include RNA binding and unfolded protein binding. An important paralog of this gene is SRSF2.

UniProtKB/Swiss-Prot for SRSF12 Gene

  • Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF12 Gene

Genomics for SRSF12 Gene

Genomic Location for SRSF12 Gene

Start:
89,095,959 bp from pter
End:
89,118,081 bp from pter
Size:
22,123 bases
Orientation:
Minus strand

Genomic View for SRSF12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF12 Gene

No data available for Regulatory Elements for SRSF12 Gene

Proteins for SRSF12 Gene

  • Protein details for SRSF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXF0-SRS12_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 12
    Protein Accession:
    Q8WXF0
    Secondary Accessions:
    • B2RA22
    • Q5T7K0
    • Q8WW25

    Protein attributes for SRSF12 Gene

    Size:
    261 amino acids
    Molecular mass:
    30512 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI16247.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW48561.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SRSF12 Gene

Proteomics data for SRSF12 Gene at MOPED

Post-translational modifications for SRSF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRSF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRSF12 Gene

Domains for SRSF12 Gene

Gene Families for SRSF12 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF12 Gene

UniProtKB/Swiss-Prot:

SRS12_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q8WXF0
Family:
  • Belongs to the splicing factor SR family.:
    • Q8WXF0
genes like me logo Genes that share domains with SRSF12: view

Function for SRSF12 Gene

Molecular function for SRSF12 Gene

UniProtKB/Swiss-Prot Function: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation.

Gene Ontology (GO) - Molecular Function for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 11684676
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0050733 RS domain binding NAS 11684676
genes like me logo Genes that share ontologies with SRSF12: view

miRNA for SRSF12 Gene

miRTarBase miRNAs that target SRSF12

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRSF12 Gene

Localization for SRSF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF12 Gene COMPARTMENTS Subcellular localization image for SRSF12 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm ISS 11684676
genes like me logo Genes that share ontologies with SRSF12: view

Pathways for SRSF12 Gene

SuperPathways for SRSF12 Gene

No Data Available

Interacting Proteins for SRSF12 Gene

Gene Ontology (GO) - Biological Process for SRSF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 11684676
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 11684676
GO:0000395 mRNA 5-splice site recognition IDA 11684676
GO:0016482 cytoplasmic transport ISS 11684676
GO:0048025 negative regulation of mRNA splicing, via spliceosome ISS 11684676
genes like me logo Genes that share ontologies with SRSF12: view

No data available for Pathways by source for SRSF12 Gene

Transcripts for SRSF12 Gene

Unigene Clusters for SRSF12 Gene

Serine/arginine-rich splicing factor 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for SRSF12 Gene

GeneLoc Exon Structure for
SRSF12
ECgene alternative splicing isoforms for
SRSF12

Expression for SRSF12 Gene

mRNA expression in normal human tissues for SRSF12 Gene

mRNA differential expression in normal tissues according to GTEx for SRSF12 Gene

This gene is overexpressed in Testis (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF12 Gene

SOURCE GeneReport for Unigene cluster for SRSF12 Gene Hs.254414

mRNA Expression by UniProt/SwissProt for SRSF12 Gene

Q8WXF0-SRS12_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with SRSF12: view

Orthologs for SRSF12 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF12 36
  • 99.74 (n)
  • 100 (a)
SRSF12 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRSF12 36
  • 94.51 (n)
  • 98.08 (a)
SRSF12 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF12 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf12 16
Srsf12 37
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRSF12 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 49 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Srsf12 36
  • 84.93 (n)
  • 90.8 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf12 36
  • 74.63 (n)
  • 79.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9386 36
fruit fly
(Drosophila melanogaster)
Insecta SC35 37
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 37
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4661 37
  • 46 (a)
OneToMany
Species with no ortholog for SRSF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SRSF12 Gene

ENSEMBL:
Gene Tree for SRSF12 (if available)
TreeFam:
Gene Tree for SRSF12 (if available)

Paralogs for SRSF12 Gene

Paralogs for SRSF12 Gene

Selected SIMAP similar genes for SRSF12 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SRSF12 Gene

genes like me logo Genes that share paralogs with SRSF12: view

Variants for SRSF12 Gene

Sequence variations from dbSNP and Humsavar for SRSF12 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs423516 -- 89,118,336(-) CACTG(A/C)CCCCA upstream-variant-2KB
rs1054973 -- 89,096,169(-) AGAAA(A/G)AAATG utr-variant-3-prime
rs1116468 -- 89,099,186(+) GGATC(A/G)GTTCT intron-variant
rs1590957 -- 89,100,692(-) ctgaa(C/T)gatct intron-variant
rs1590958 -- 89,099,218(+) GTCTG(A/G)GTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF12 Gene

Variant ID Type Subtype PubMed ID
nsv886336 CNV Loss 21882294
nsv886337 CNV Loss 21882294

Relevant External Links for SRSF12 Gene

HapMap Linkage Disequilibrium report
SRSF12

Disorders for SRSF12 Gene

Relevant External Links for SRSF12

Genetic Association Database (GAD)
SRSF12
genes like me logo Genes that share disorders with SRSF12: view

No data available for UniProtKB/Swiss-Prot for SRSF12 Gene

Publications for SRSF12 Gene

  1. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PMID: 11684676) Cowper A.E. … Screaton G.R. (J. Biol. Chem. 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3
  5. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PMID: 22094256) Anders L. … Sicinski P. (Cancer Cell 2011) 3

Products for SRSF12 Gene

Sources for SRSF12 Gene

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