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SRSF12 Gene

protein-coding   GIFtS: 46
GCID: GC06M089805

Serine/Arginine-Rich Splicing Factor 12

(Previous names: splicing factor, arginine/serine-rich 13B)
(Previous symbol: SFRS13B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine-Rich Splicing Factor 121 2     SFRS192 3
Splicing Factor, Arginine/Serine-Rich 13B1 2 3     SRrp352 3
SFRS13B1 2 3     Arginine/Serine-Rich 191
SR Splicing Factor 121 2     Splicing Factor1
Splicing Factor, Arginine/Serine-Rich 192 3     Serine-Arginine Repressor Protein (35 KDa)2
35 KDa SR Repressor Protein2 3     SRRP353

External Ids:    HGNC: 212201   Entrez Gene: 1352952   Ensembl: ENSG000001545487   UniProtKB: Q8WXF03   

Export aliases for SRSF12 gene to outside databases

Previous GC identifer: GC06M087021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRSF12 Gene:
SRSF12 (serine/arginine-rich splicing factor 12) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and RNA binding. An important paralog of this gene is LOC100996657.

UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0
Function: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF12
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF12 promoter sequence
   Search Chromatin IP Primers for SRSF12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q16.1

SRSF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF12 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M089805:  view genomic region     (about GC identifiers)

Start:
89,805,678 bp from pter      End:
89,827,800 bp from pter
Size:
22,123 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 12  
Size: 261 amino acids; 30512 Da
Sequence caution: Sequence=CAI16247.1; Type=Erroneous gene model prediction; Sequence=EAW48561.1; Type=Erroneous
gene model prediction;
Secondary accessions: B2RA22 Q5T7K0 Q8WW25

Explore the universe of human proteins at neXtProt for SRSF12: NX_Q8WXF0

Explore proteomics data for SRSF12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SRSF12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542781.3  
    ENSEMBL proteins: 
     ENSP00000414302   ENSP00000430513   ENSP00000427982  

    SRSF12 Human Recombinant Protein Products:

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    antibodies-online antibodies for SRSF12 (6 products) 

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    antibodies-online kits for SRSF12 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q8WXF0

    ProtoNet protein and cluster: Q8WXF0

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SRSF12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRS12_HUMAN, Q8WXF0
    Function: Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS11684676
    GO:0044822poly(A) RNA binding IDA--
    GO:0050733RS domain binding NAS11684676
         
    Find genes that share ontologies with SRSF12           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SRSF12

    miRNA
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    miRTarBase miRNAs that target SRSF12:
    hsa-mir-335-5p (MIRT019116)

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    Selected qRT-PCR Assays for microRNAs that regulate SRSF12 (see all 52):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4272 hsa-miR-146a hsa-miR-106a hsa-miR-548k
    SwitchGear 3'UTR luciferase reporter plasmidSRSF12 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRS12_HUMAN, Q8WXF0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm ISS11684676

    Find genes that share ontologies with SRSF12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF12
    Interactions:

        Search GeneGlobe Interaction Network for SRSF12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for SRSF12 (ENSP000004143024) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK6ENSP000002657344STRING: ENSP00000265734
    SRSF7ENSP000003259054STRING: ENSP00000325905
    CRNKL1ENSP000003665574STRING: ENSP00000366557
    ISY1ENSP000003769734STRING: ENSP00000376973
    PLRG1ENSP000003031914STRING: ENSP00000303191
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000244spliceosomal tri-snRNP complex assembly NAS11684676
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA11684676
    GO:0000395mRNA 5'-splice site recognition IDA11684676
    GO:0016482cytoplasmic transport ISS11684676
    GO:0048025negative regulation of mRNA splicing, via spliceosome ISS11684676

    Find genes that share ontologies with SRSF12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF12 (SRS12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRSF12 gene: 
    NM_080743.4  

    Unigene Cluster for SRSF12:

    Serine/arginine-rich splicing factor 12
    Hs.254414  [show with all ESTs]
    Unigene Representative Sequence: NM_080743
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452027(uc021zcq.1) ENST00000524221 ENST00000488604 ENST00000475068
    ENST00000517387
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRSF12 (see all 52):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-4272 hsa-miR-146a hsa-miR-106a hsa-miR-548k
    SwitchGear 3'UTR luciferase reporter plasmidSRSF12 3' UTR sequence
    Inhib. RNA
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      Search QuantiFast Probe-based Assays in human, mouse, rat SRSF12

    Additional mRNA sequence: 

    AF449428.1 AK090803.1 AK123215.1 AK314008.1 BC021715.1 

    5 DOTS entries:

    DT.86841496  DT.92417336  DT.101977177  DT.431523  DT.97805846 

    Selected AceView cDNA sequences (see all 28):

    BP362656 AA889416 AF449428 AK090803 AI206456 AK123215 AA972419 BG718755 
    AI638470 AW043659 BE502279 BX472788 BG722510 AI632614 NM_080743 AI808562 
    BC021715 BU852922 BX105734 BI460898 BM721805 AI077367 BG701008 CD359161 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF12    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6a · 6b
    SP1:                          -     -     -     -                                       
    SP2:                    -           -     -                                             
    SP3:                    -           -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for SRSF12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRSF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAGAAAGA
    SRSF12 Expression
    About this image

    SRSF12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.254414

    UniProtKB/Swiss-Prot: SRS12_HUMAN, Q8WXF0
    Tissue specificity: Expressed in testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRSF12 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf125 serine/arginine-rich splicing factor 12   --   4 (14.73 cM) 33208991 
    African clawed frog
    (Xenopus laevis)
    Amphibia BU910256.12   -- 76.94(n)    BU910256.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Actinopterygii Omy.93862 Oncorhynchus mykiss transcribed sequence with weak more 76.42(n)    CA367290.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SC356
    SC35
    34(a)
    1 → many
    2L(12431075-12434665)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-46
    Protein RSP-4, isoform b (rsp-4) mRNA, complete cd...
    36(a)
    1 → many
    II(5387419-5388830) WBGene00004701


    ENSEMBL Gene Tree for SRSF12 (if available)
    TreeFam Gene Tree for SRSF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRSF12 gene
    LOC1009966572  SRSF22  ENSG000002718852  SRSF102  
    12 SIMAP similar genes for SRSF12 using alignment to 3 protein entries:     SRS12_HUMAN (see all proteins):
    SRrp35    FUSIP1    SRSF10    SFRS2    SFRS3    SRSF3
    SRSF2    SFRS5    SRSF7    SRSF8    P14    SF3B14

    Find genes that share paralogs with SRSF12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SRSF12
    PGOHUM00000248183


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRSF12 (see all 571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900745121,2
    C--89805270(+) ATTTTC/GCCTCT 1 -- ds50010--------
    rs1928443451,2
    --89805279(+) CTGGCA/GATGGG 1 -- ds50010--------
    rs1460449171,2
    C--89805303(+) CAGCAA/GTTCTT 1 -- ds50010--------
    rs1127467861,2
    C,F--89805426(+) AAATCC/TGAGGC 1 -- ds50012Minor allele frequency- T:0.02NA 122
    rs1847960301,2
    --89805443(+) TAAAAA/TTTTCA 1 -- ds50010--------
    rs1116217121,2
    C,F--89805486(+) AATATG/CAGCTG 1 -- ds50011Minor allele frequency- C:0.50NA 2
    rs737548531,2
    C--89805537(+) CAAGCC/AGCTGT 1 -- ds50012Minor allele frequency- A:0.29WA 120
    rs1892587731,2
    --89805556(+) TCTCTA/GTTTTC 1 -- ds50010--------
    rs2015084881,2
    C--89805565(-) AGGGTA/CAAAGA 1 -- ds50010--------
    rs99184221,2
    C,F--89805762(+) AACCCT/CGGAAT 1 -- ut311Minor allele frequency- C:0.15WA 118

    HapMap Linkage Disequilibrium report for SRSF12 (89805678 - 89827800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SRSF12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv886336CNV Loss21882294
    nsv886337CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF12
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SRSF12           About GenesLikeMe

    Genetic Association Database (GAD): SRSF12

    Export disorders for SRSF12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRSF12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SRSF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PubMed id 11684676)1, 2, 3, 9 Cowper A.E.... Screaton G.R. (J. Biol. Chem. 2001)
    2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (Cell 2012)
    7. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. (PubMed id 22094256)1 Anders L....Sicinski P. (Cancer Cell 2011)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 135295 HGNC: 21220 AceView: SRrp35 Ensembl:ENSG00000154548 euGenes: HUgn135295
    ECgene: SRSF12 H-InvDB: SRSF12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRSF12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRSF12 gene:
    Search GeneIP for patents involving SRSF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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