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Aliases for SRSF11 Gene

Aliases for SRSF11 Gene

  • Serine/Arginine-Rich Splicing Factor 11 2 3
  • Splicing Factor, Arginine/Serine-Rich 11 2 3 4
  • SFRS11 3 4 6
  • Arginine-Rich 54 KDa Nuclear Protein 3 4
  • SR Splicing Factor 11 2 3
  • P54 3 4
  • Splicing Factor P54 3
  • DJ677H15.2 3
  • NET2 3

External Ids for SRSF11 Gene

Previous Symbols for SRSF11 Gene

  • SFRS11

Summaries for SRSF11 Gene

Entrez Gene Summary for SRSF11 Gene

  • This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF11 Gene

SRSF11 (Serine/Arginine-Rich Splicing Factor 11) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SREK1.

UniProtKB/Swiss-Prot for SRSF11 Gene

  • May function in pre-mRNA splicing

Gene Wiki entry for SRSF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF11 Gene

Genomics for SRSF11 Gene

Genomic Location for SRSF11 Gene

Start:
70,205,682 bp from pter
End:
70,253,052 bp from pter
Size:
47,371 bases
Orientation:
Plus strand

Genomic View for SRSF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF11 Gene

No data available for Regulatory Elements for SRSF11 Gene

Proteins for SRSF11 Gene

  • Protein details for SRSF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05519-SRS11_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 11
    Protein Accession:
    Q05519
    Secondary Accessions:
    • Q5T758
    • Q8IWE6

    Protein attributes for SRSF11 Gene

    Size:
    484 amino acids
    Molecular mass:
    53542 Da
    Quaternary structure:
    • Interacts with PUF60.

    Alternative splice isoforms for SRSF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF11 Gene

Proteomics data for SRSF11 Gene at MOPED

Post-translational modifications for SRSF11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys58, Lys82, and Lys197

Other Protein References for SRSF11 Gene

No data available for DME Specific Peptides for SRSF11 Gene

Domains for SRSF11 Gene

Gene Families for SRSF11 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF11 Gene

UniProtKB/Swiss-Prot:

SRS11_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q05519
Family:
  • Belongs to the splicing factor SR family.:
    • Q05519
genes like me logo Genes that share domains with SRSF11: view

Function for SRSF11 Gene

Molecular function for SRSF11 Gene

UniProtKB/Swiss-Prot Function: May function in pre-mRNA splicing

Gene Ontology (GO) - Molecular Function for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 20195357
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF11: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRSF11 Gene

Localization for SRSF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF11 Gene

Nucleus. Note=Colocalizes with spliceosome components.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF11 Gene COMPARTMENTS Subcellular localization image for SRSF11 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 1896467
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with SRSF11: view

Pathways for SRSF11 Gene

genes like me logo Genes that share pathways with SRSF11: view

Gene Ontology (GO) - Biological Process for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing TAS 1896467
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF11: view

Transcripts for SRSF11 Gene

Unigene Clusters for SRSF11 Gene

Serine/arginine-rich splicing factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: -
SP6:
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - -
SP17: - - -
SP18: -
SP19: - - - -
SP20: - -
SP21:
SP22:

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for SRSF11 Gene

GeneLoc Exon Structure for
SRSF11
ECgene alternative splicing isoforms for
SRSF11

Expression for SRSF11 Gene

mRNA expression in normal human tissues for SRSF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF11 Gene

SOURCE GeneReport for Unigene cluster for SRSF11 Gene Hs.479693

genes like me logo Genes that share expressions with SRSF11: view

Orthologs for SRSF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS11 37
  • 98 (a)
OneToOne
SRSF11 36
  • 94.47 (n)
  • 98.55 (a)
dog
(Canis familiaris)
Mammalia SRSF11 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf11 36
  • 88.64 (n)
  • 97.57 (a)
Srsf11 16
Srsf11 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRSF11 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF11 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf11 36
  • 87.61 (n)
  • 95.8 (a)
chicken
(Gallus gallus)
Aves SRSF11 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF11 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34822 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2497 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6523 36
zebrafish
(Danio rerio)
Actinopterygii srsf11 37
  • 70 (a)
OneToOne
wufb37g02 36
fruit fly
(Drosophila melanogaster)
Insecta Srp54 37
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-7 37
  • 30 (a)
OneToMany
Species with no ortholog for SRSF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF11 Gene

ENSEMBL:
Gene Tree for SRSF11 (if available)
TreeFam:
Gene Tree for SRSF11 (if available)

Paralogs for SRSF11 Gene

Paralogs for SRSF11 Gene

Pseudogenes.org Pseudogenes for SRSF11 Gene

genes like me logo Genes that share paralogs with SRSF11: view

Variants for SRSF11 Gene

Sequence variations from dbSNP and Humsavar for SRSF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs169172 -- 70,223,994(+) AGAGA(A/G)CGTCT intron-variant
rs187943 -- 70,235,358(+) ttttT(C/T)CTTTT intron-variant
rs269281 -- 70,215,133(+) cgtga(A/G)gtgat intron-variant
rs269282 -- 70,238,039(+) ATTAT(C/T)TGCCC intron-variant
rs472623 -- 70,224,069(+) cattg(G/T)attag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF11 Gene

Variant ID Type Subtype PubMed ID
nsv870841 CNV Loss 21882294
nsv1343 CNV Insertion 18451855
nsv871898 CNV Loss 21882294
esv2671094 CNV Deletion 23128226

Relevant External Links for SRSF11 Gene

HapMap Linkage Disequilibrium report
SRSF11

Disorders for SRSF11 Gene

Relevant External Links for SRSF11

Human Genome Epidemiology (HuGE) Navigator
SRSF11
genes like me logo Genes that share disorders with SRSF11: view

No data available for UniProtKB/Swiss-Prot for SRSF11 Gene

Publications for SRSF11 Gene

  1. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. (PMID: 1896467) Chaudhary N. … Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E. … Mayeda A. (Mol. Cell. Biol. 2004) 3 23
  3. PUF60: a novel U2AF65-related splicing activity. (PMID: 10606266) Page-McCaw P.S. … Sharp P.A. (RNA 1999) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3

Products for SRSF11 Gene

Sources for SRSF11 Gene

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