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Aliases for SRSF11 Gene

Aliases for SRSF11 Gene

  • Serine And Arginine Rich Splicing Factor 11 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 11 2 3 4
  • Serine/Arginine-Rich Splicing Factor 11 2 3
  • Arginine-Rich 54 KDa Nuclear Protein 3 4
  • SR Splicing Factor 11 2 3
  • SFRS11 3 4
  • P54 3 4
  • Splicing Factor P54 3
  • DJ677H15.2 3
  • NET2 3

External Ids for SRSF11 Gene

Previous HGNC Symbols for SRSF11 Gene

  • SFRS11

Previous GeneCards Identifiers for SRSF11 Gene

  • GC01P070672
  • GC01P068782

Summaries for SRSF11 Gene

Entrez Gene Summary for SRSF11 Gene

  • This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF11 Gene

SRSF11 (Serine And Arginine Rich Splicing Factor 11) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SREK1.

UniProtKB/Swiss-Prot for SRSF11 Gene

  • May function in pre-mRNA splicing.

Gene Wiki entry for SRSF11 Gene

Additional gene information for SRSF11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF11 Gene

Genomics for SRSF11 Gene

Regulatory Elements for SRSF11 Gene

Enhancers for SRSF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H070409 1.4 FANTOM5 ENCODE 37.8 +205.6 205551 3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 SRSF11 HHLA3 ZRANB2 ANKRD13C CTH ENSG00000278636
GH01H070203 1.4 ENCODE dbSUPER 29.8 +0.2 199 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 SRSF11 ZRANB2 LRRC40 ENSG00000228988
GH01H071079 1.1 ENCODE 24.1 +875.1 875086 2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ZNF207 SRSF11 PTGER3 ZRANB2 MIR186
GH01H071046 1.4 Ensembl ENCODE dbSUPER 10.6 +841.6 841600 1 HDAC1 TBP ATF1 RB1 NFRKB ZNF766 EGR1 ATF7 EGR2 SP3 SRSF11 PTGER3 ZRANB2-AS1
GH01H070219 1.3 ENCODE dbSUPER 10.9 +16.1 16073 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SRSF11 LRRC40 ENSG00000228988 GC01P070230
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRSF11 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008414 -82 2801 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143

Genomic Location for SRSF11 Gene

Chromosome:
1
Start:
70,205,682 bp from pter
End:
70,253,052 bp from pter
Size:
47,371 bases
Orientation:
Plus strand

Genomic View for SRSF11 Gene

Genes around SRSF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF11 Gene

Proteins for SRSF11 Gene

  • Protein details for SRSF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05519-SRS11_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 11
    Protein Accession:
    Q05519
    Secondary Accessions:
    • Q5T758
    • Q8IWE6

    Protein attributes for SRSF11 Gene

    Size:
    484 amino acids
    Molecular mass:
    53542 Da
    Quaternary structure:
    • Interacts with PUF60.

    Alternative splice isoforms for SRSF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF11 Gene

Post-translational modifications for SRSF11 Gene

  • Ubiquitination at Lys58, posLast=8282, and posLast=197197
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRSF11 Gene

Domains & Families for SRSF11 Gene

Gene Families for SRSF11 Gene

Protein Domains for SRSF11 Gene

Graphical View of Domain Structure for InterPro Entry

Q05519

UniProtKB/Swiss-Prot:

SRS11_HUMAN :
  • Belongs to the splicing factor SR family.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF11: view

Function for SRSF11 Gene

Molecular function for SRSF11 Gene

UniProtKB/Swiss-Prot Function:
May function in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 22658674
GO:0005515 protein binding IPI 17353931
genes like me logo Genes that share ontologies with SRSF11: view
genes like me logo Genes that share phenotypes with SRSF11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF11 Gene

Localization for SRSF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF11 Gene

Nucleus. Note=Colocalizes with spliceosome components.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRSF11 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 1896467
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with SRSF11: view

Pathways & Interactions for SRSF11 Gene

genes like me logo Genes that share pathways with SRSF11: view

Gene Ontology (GO) - Biological Process for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing TAS 1896467
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRSF11: view

No data available for SIGNOR curated interactions for SRSF11 Gene

Drugs & Compounds for SRSF11 Gene

No Compound Related Data Available

Transcripts for SRSF11 Gene

Unigene Clusters for SRSF11 Gene

Serine/arginine-rich splicing factor 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRSF11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: -
SP6:
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - -
SP17: - - -
SP18: -
SP19: - - - -
SP20: - -
SP21:
SP22:

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for SRSF11 Gene

GeneLoc Exon Structure for
SRSF11
ECgene alternative splicing isoforms for
SRSF11

Expression for SRSF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRSF11 Gene

Protein differential expression in normal tissues from HIPED for SRSF11 Gene

This gene is overexpressed in Lymph node (11.0) and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRSF11 Gene



Protein tissue co-expression partners for SRSF11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRSF11 Gene:

SRSF11

SOURCE GeneReport for Unigene cluster for SRSF11 Gene:

Hs.479693

Evidence on tissue expression from TISSUES for SRSF11 Gene

  • Liver(4.6)
  • Nervous system(4.4)
  • Lung(3.8)
  • Bone marrow(2.1)
  • Spleen(2.1)
  • Intestine(2)
  • Kidney(2)
  • Lymph node(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with SRSF11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRSF11 Gene

Orthologs for SRSF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF11 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS11 34
  • 98 (a)
OneToOne
SRSF11 33
  • 94.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF11 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRSF11 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf11 16 34 33
  • 88.64 (n)
rat
(Rattus norvegicus)
Mammalia Srsf11 33
  • 87.61 (n)
oppossum
(Monodelphis domestica)
Mammalia SRSF11 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRSF11 34
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF11 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2497 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.34822 33
zebrafish
(Danio rerio)
Actinopterygii srsf11 34
  • 70 (a)
OneToOne
wufb37g02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6523 33
fruit fly
(Drosophila melanogaster)
Insecta Srp54 34
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-7 34
  • 30 (a)
OneToMany
Species where no ortholog for SRSF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF11 Gene

ENSEMBL:
Gene Tree for SRSF11 (if available)
TreeFam:
Gene Tree for SRSF11 (if available)

Paralogs for SRSF11 Gene

Paralogs for SRSF11 Gene

Pseudogenes.org Pseudogenes for SRSF11 Gene

genes like me logo Genes that share paralogs with SRSF11: view

Variants for SRSF11 Gene

Sequence variations from dbSNP and Humsavar for SRSF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000042106 -- 70,227,155(+) TTTTT(A/G)TTAGG intron-variant
rs1000043531 -- 70,234,891(+) GTTGT(A/G)GTAAT intron-variant
rs1000108843 -- 70,211,743(+) ATGCA(C/T)CATCA intron-variant
rs1000219287 -- 70,209,888(+) GCCAC(A/G)ATGCC intron-variant
rs1000249063 -- 70,229,021(+) TGAAT(A/T)TCAGT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SRSF11 Gene

Variant ID Type Subtype PubMed ID
esv2671094 CNV deletion 23128226
esv3586351 CNV loss 21293372
nsv1014292 CNV gain 25217958
nsv1076523 CNV deletion 25765185
nsv1343 CNV insertion 18451855
nsv950171 CNV duplication 24416366

Variation tolerance for SRSF11 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRSF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF11 Gene

Disorders for SRSF11 Gene

Relevant External Links for SRSF11

Human Genome Epidemiology (HuGE) Navigator
SRSF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF11

No disorders were found for SRSF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRSF11 Gene

Publications for SRSF11 Gene

  1. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. (PMID: 1896467) Chaudhary N … Blobel G (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22 60
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley JL … Krainer AR (Genes & development 2010) 2 3 60
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60
  4. Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E … Mayeda A (Molecular and cellular biology 2004) 3 22 60
  5. PUF60: a novel U2AF65-related splicing activity. (PMID: 10606266) Page-McCaw PS … Sharp PA (RNA (New York, N.Y.) 1999) 3 4 60

Products for SRSF11 Gene

Sources for SRSF11 Gene

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