Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SRSF11 Gene

Aliases for SRSF11 Gene

  • Serine/Arginine-Rich Splicing Factor 11 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 11 2 3 4
  • Arginine-Rich 54 KDa Nuclear Protein 3 4
  • SR Splicing Factor 11 2 3
  • SFRS11 3 4
  • P54 3 4
  • Splicing Factor P54 3
  • DJ677H15.2 3
  • NET2 3

External Ids for SRSF11 Gene

Previous HGNC Symbols for SRSF11 Gene

  • SFRS11

Previous GeneCards Identifiers for SRSF11 Gene

  • GC01P070672
  • GC01P068782

Summaries for SRSF11 Gene

Entrez Gene Summary for SRSF11 Gene

  • This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.[provided by RefSeq, Sep 2010]

GeneCards Summary for SRSF11 Gene

SRSF11 (Serine/Arginine-Rich Splicing Factor 11) is a Protein Coding gene. Diseases associated with SRSF11 include exudative vitreoretinopathy 5. Among its related pathways are Gene Expression and Transport of Mature Transcript to Cytoplasm. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SREK1.

UniProtKB/Swiss-Prot for SRSF11 Gene

  • May function in pre-mRNA splicing.

Gene Wiki entry for SRSF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF11 Gene

Genomics for SRSF11 Gene

Regulatory Elements for SRSF11 Gene

Promoters for SRSF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRSF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRSF11 Gene

Chromosome:
1
Start:
70,205,682 bp from pter
End:
70,253,052 bp from pter
Size:
47,371 bases
Orientation:
Plus strand

Genomic View for SRSF11 Gene

Genes around SRSF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF11 Gene

Proteins for SRSF11 Gene

  • Protein details for SRSF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05519-SRS11_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 11
    Protein Accession:
    Q05519
    Secondary Accessions:
    • Q5T758
    • Q8IWE6

    Protein attributes for SRSF11 Gene

    Size:
    484 amino acids
    Molecular mass:
    53542 Da
    Quaternary structure:
    • Interacts with PUF60.

    Alternative splice isoforms for SRSF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRSF11 Gene

Proteomics data for SRSF11 Gene at MOPED

Post-translational modifications for SRSF11 Gene

  • Ubiquitination at Lys 58, Lys 82, and Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for SRSF11 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SRSF11

No data available for DME Specific Peptides for SRSF11 Gene

Domains & Families for SRSF11 Gene

Protein Domains for SRSF11 Gene

Graphical View of Domain Structure for InterPro Entry

Q05519

UniProtKB/Swiss-Prot:

SRS11_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF11: view

Function for SRSF11 Gene

Molecular function for SRSF11 Gene

UniProtKB/Swiss-Prot Function:
May function in pre-mRNA splicing.
genes like me logo Genes that share phenotypes with SRSF11: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRSF11 Gene

Localization for SRSF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF11 Gene

Nucleus. Note=Colocalizes with spliceosome components.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF11 Gene COMPARTMENTS Subcellular localization image for SRSF11 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for SRSF11 Gene

Pathways & Interactions for SRSF11 Gene

genes like me logo Genes that share pathways with SRSF11: view

Gene Ontology (GO) - Biological Process for SRSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0008380 RNA splicing TAS 1896467
genes like me logo Genes that share ontologies with SRSF11: view

No data available for SIGNOR curated interactions for SRSF11 Gene

Drugs & Compounds for SRSF11 Gene

No Compound Related Data Available

Transcripts for SRSF11 Gene

Unigene Clusters for SRSF11 Gene

Serine/arginine-rich splicing factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - -
SP5: -
SP6:
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - -
SP14: - - - - - -
SP15: - - - - - - -
SP16: - - -
SP17: - - -
SP18: -
SP19: - - - -
SP20: - -
SP21:
SP22:

ExUns: 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for SRSF11 Gene

GeneLoc Exon Structure for
SRSF11
ECgene alternative splicing isoforms for
SRSF11

Expression for SRSF11 Gene

mRNA expression in normal human tissues for SRSF11 Gene

Protein differential expression in normal tissues from HIPED for SRSF11 Gene

This gene is overexpressed in Lymph node (11.0) and Testis (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF11 Gene



SOURCE GeneReport for Unigene cluster for SRSF11 Gene Hs.479693

genes like me logo Genes that share expression patterns with SRSF11: view

Protein tissue co-expression partners for SRSF11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRSF11 Gene

Orthologs for SRSF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRSF11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRS11 36
  • 98 (a)
OneToOne
SRSF11 35
  • 94.47 (n)
  • 98.55 (a)
dog
(Canis familiaris)
Mammalia SRSF11 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srsf11 36
  • 89 (a)
OneToOne
Srsf11 16
Srsf11 35
  • 88.64 (n)
  • 97.57 (a)
oppossum
(Monodelphis domestica)
Mammalia SRSF11 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRSF11 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Srsf11 35
  • 87.61 (n)
  • 95.8 (a)
chicken
(Gallus gallus)
Aves SRSF11 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRSF11 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34822 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2497 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6523 35
zebrafish
(Danio rerio)
Actinopterygii wufb37g02 35
srsf11 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Srp54 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-7 36
  • 30 (a)
OneToMany
Species with no ortholog for SRSF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF11 Gene

ENSEMBL:
Gene Tree for SRSF11 (if available)
TreeFam:
Gene Tree for SRSF11 (if available)

Paralogs for SRSF11 Gene

Paralogs for SRSF11 Gene

Pseudogenes.org Pseudogenes for SRSF11 Gene

genes like me logo Genes that share paralogs with SRSF11: view

Variants for SRSF11 Gene

Sequence variations from dbSNP and Humsavar for SRSF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs187943 -- 70,235,358(+) ttttT(C/T)CTTTT intron-variant
rs269281 -- 70,215,133(+) cgtga(A/G)gtgat intron-variant
rs169172 -- 70,223,994(+) AGAGA(A/G)CGTCT intron-variant
rs1412867 -- 70,245,553(-) CACTC(C/T)TCTCC intron-variant
rs2034756 -- 70,244,890(+) AAAGA(G/T)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF11 Gene

Variant ID Type Subtype PubMed ID
nsv870841 CNV Loss 21882294
nsv1343 CNV Insertion 18451855
nsv871898 CNV Loss 21882294
esv2671094 CNV Deletion 23128226

Variation tolerance for SRSF11 Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRSF11 Gene

HapMap Linkage Disequilibrium report
SRSF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF11 Gene

Disorders for SRSF11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRSF11 Gene - From: OMIM

Disorder Aliases PubMed IDs
exudative vitreoretinopathy 5
  • vitreoretinopathy, exudative 5
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SRSF11

Human Genome Epidemiology (HuGE) Navigator
SRSF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF11
genes like me logo Genes that share disorders with SRSF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF11 Gene

Publications for SRSF11 Gene

  1. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. (PMID: 1896467) Chaudhary N. … Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23 67
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3
  3. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PMID: 14729963) Sakashita E. … Mayeda A. (Mol. Cell. Biol. 2004) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SRSF11 Gene

Sources for SRSF11 Gene

Back to Top

Content