Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF11 Gene

protein-coding   GIFtS: 53
GCID: GC01P070672

serine/arginine-rich splicing factor 11

(Previous names: splicing factor, arginine/serine-rich 11 )
(Previous symbol: SFRS11)
 Explore 4 diseases affiliated with
SRSF11 via our new
 Human Malady Compendium 
Biological research products
for SRSF11
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serine/Arginine-Rich Splicing Factor 111 2     Arginine-Rich 54 KDa Nuclear Protein2 3
Splicing Factor, Arginine/Serine-Rich 111 2 3     DJ677H15.21
SFRS111 2 3     Splicing Factor P542
P541     SR Splicing Factor 112
NET21 2     

External Ids:    HGNC: 107821   Entrez Gene: 92952   Ensembl: ENSG000001167547   OMIM: 6020105   UniProtKB: Q055193   

Export aliases for SRSF11 gene to outside databases

Previous GC identifer: GC01P068782


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF11:
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in
pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization
data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in multiple transcript
variants encoding different proteins. In addition, a pseudogene of this gene has been found on chromosome 12.(provided
by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: SRS11_HUMAN, Q05519
Function: May function in pre-mRNA splicing

Gene Wiki entry for SRSF11 (SFRS11)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF11
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRSF11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

SRSF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P070672:  view genomic region     (about GC identifiers)

Start:
70,671,365 bp from pter      End:
70,718,735 bp from pter
Size:
47,371 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRS11_HUMAN, Q05519 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 11  
Size: 484 amino acids; 53542 Da
Subunit: Interacts with PUF60
Subcellular location: Nucleus. Note=Colocalizes with spliceosome components
Secondary accessions: Q5T758 Q8IWE6
Alternative splicing: 2 isoforms:  Q05519-1   Q05519-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF11: NX_Q05519

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05519

  • SRSF11 Protein expression data from MOPED and PaxDb:    About this image 
    SRSF11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001177916.1  NP_004759.1  

    ENSEMBL proteins: 
     ENSP00000359989   ENSP00000359988   ENSP00000378568   ENSP00000359987   ENSP00000384357  
     ENSP00000405120   ENSP00000411159  
    Reactome Protein details: Q05519
    Human Recombinant Protein Products for SRSF11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SRSF11
    OriGene Custom Protein Services for SRSF11 
    GenScript Custom Purified and Recombinant Proteins Services for SRSF11
    Novus Biologicals SRSF11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SRSF11

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    SRSF11 for ontologies           About GeneDecksing



    SRSF11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRSF11 
    GenScript Custom Superior Antibodies Services for SRSF11
    Novus Biologicals SRSF11 Antibodies
    Abcam antibodies for SRSF11 
    Uscn Antibodies for SRSF11
    Search ThermoFisher Antibodies for SRSF11

    Assay Products for SRSF11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRSF11
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SRSF11


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SRSF11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q05519

    ProtoNet protein and cluster: Q05519

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRS11_HUMAN, Q05519
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRS11_HUMAN, Q05519
    Function: May function in pre-mRNA splicing

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
         
    SRSF11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SRSF11 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRSF11:
    hsa-mir-376a (MIRT004025)

    OriGene 3'-UTR Clone: SRSF11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF11
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF11 (see all 20):
    hsa-miR-148b hsa-miR-24-1* hsa-miR-509-5p hsa-miR-138-2* hsa-miR-24-2* hsa-miR-548g hsa-miR-205* hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidSRSF11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF11 (see all 7)
    OriGene shRNA RFP: SRSF11
    OriGene siRNA: SRSF11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF11
    Sirion Biotech Custom design and validation of potent shRNA sequences against SRSF11 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRSF11
    Sirion Biotech Customized adenovirus for overexpression of SRSF11 
    Sirion Biotech Customized adenovirus for potent knockdown of SRSF11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF11 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF11 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF11 (NM_004768)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRSF11
    Search LifeMap BioReagents cell lines for SRSF11
    Sirion Biotech Customized stable knockdown cell line services for SRSF11 
    Sirion Biotech Customized inducible knockdown cell line services for SRSF11
    Sirion Biotech Customized stable overexpressing cell line services for SRSF11
    Sirion Biotech Customized inducible overexpressing cell line services for SRSF11

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination1.00
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    Post-Elongation Processing of the Transcript1.00
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 1.00
    2mRNA Splicing - Major Pathway
    mRNA Splicing1.00
    Processing of Capped Intron-Containing Pre-mRNA0.96
    mRNA Splicing - Major Pathway1.00
    mRNA Processing0.82
    3Transcription
    Transcription1.00
    RNA Polymerase II Transcription0.69
    4Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm1.00
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    5Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/14        Reactome Pathways for SRSF11 (see all 14)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription



    SRSF11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/677 Interacting proteins for SRSF11 (Q055191, 2, 3 ENSP000003599884) via UniProtKB, MINT, STRING, and/or I2D (see all 677)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149211, 3, ENSP000003764364EBI-1051785,EBI-913209 I2D: score=1 STRING: ENSP00000376436
    PUF60Q9UHX12, 3, ENSP000003220164MINT-7945693 I2D: score=4 STRING: ENSP00000322016
    SRSF1Q079552, 3, ENSP000002589624MINT-7945693 I2D: score=3 STRING: ENSP00000258962
    SRSF2Q011302, 3, ENSP000003508774MINT-7945693 I2D: score=3 STRING: ENSP00000350877
    U2AF2P263682, 3, ENSP000003078634MINT-7945693 I2D: score=3 STRING: ENSP00000307863
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS1896467
    GO:0006406mRNA export from nucleus TAS--

    SRSF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF11
    Search CenterWatch for drugs/clinical trials and news about SRSF11 / SRS11 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRSF11 gene (2 alternative transcripts): 
    NM_001190987.1  NM_004768.3  

    Unigene Cluster for SRSF11:

    Serine/arginine-rich splicing factor 11
    Hs.479693  [show with all ESTs]
    Unigene Representative Sequence: BX640645
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000370951(uc009wbi.3) ENST00000463877 ENST00000370950(uc001det.3 uc001des.3)
    ENST00000475204 ENST00000395136(uc001deu.2) ENST00000473950 ENST00000469170
    ENST00000486667 ENST00000481648 ENST00000463116 ENST00000484162(uc001dev.3)
    ENST00000370949(uc001dew.3) ENST00000463859 ENST00000460795 ENST00000461935
    ENST00000489188 ENST00000405432 ENST00000436161

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: SRSF11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF11
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF11 (see all 20):
    hsa-miR-148b hsa-miR-24-1* hsa-miR-509-5p hsa-miR-138-2* hsa-miR-24-2* hsa-miR-548g hsa-miR-205* hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidSRSF11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF11 (see all 7)
    OriGene shRNA RFP: SRSF11
    OriGene siRNA: SRSF11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF11
    Sirion Biotech Custom design and validation of potent shRNA sequences against SRSF11 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF11 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF11 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF11 (NM_004768)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF11 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRSF11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF11

    Additional cDNA sequence: 

    AB062486.1 AK300147.1 AK301670.1 AK310447.1 AK310666.1 AK311184.1 AL832279.1 BC002784.2 
    BC009840.2 BC017359.2 BC022815.1 BC032727.1 BC040436.1 BX537679.1 BX640645.1 BX641004.1 
    M74002.1 

    24/39 DOTS entries (see all 39):

    DT.441504  DT.219368  DT.101985035  DT.92458648  DT.95258238  DT.100875482  DT.219363  DT.100731211 
    DT.40276859  DT.92057476  DT.85104163  DT.97767765  DT.97856065  DT.121411784  DT.121411659  DT.95258218 
    DT.95258224  DT.95258244  DT.100677405  DT.100892579  DT.121411748  DT.121411759  DT.95258245  DT.100059238 

    24/648 AceView cDNA sequences (see all 648):

    BM750774 BC040436 AA927542 BP366034 AU131222 CB241000 AA683543 CA449074 
    BG571712 AA831969 AW874312 AU118996 AI446378 BQ022377 F02283 BI334259 
    CR614713 BX456885 CB132307 AI628713 AI039563 AA314088 CA423820 AA356226 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF11 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^
    SP1:                                      -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP2:                    -     -           -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP3:                    -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP4:                    -     -           -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SRSF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGATGTACA
    SRSF11 Expression
    About this image
    See SRSF11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF11

    SOURCE GeneReport for Unigene cluster: Hs.479693
        SABiosciences Custom PCR Arrays for SRSF11

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRSF11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRSF11 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SRSF111 serine/arginine-rich splicing factor 11 84(n)
    94.91(a)
      424714  NM_001031296.1  NP_001026467.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF116
    --
    89(a)
    1 ↔ 1
    GL343328.1(1162090-1189773)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.348222 Xenopus laevis transcribed sequence with moderate similarity more 80.2(n)    CA971280.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb37g022 wufb37g02 73.71(n)   321886  BC044186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp546
    CG63406
    (see all 3)
    --
    27(a)
    2(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    2L(9912911-9915044)
    X(15376410-15380645)
    worm
    (Caenorhabditis elegans)
    Secernentea Y119C1B.16
    H27M09.56
    (see all 3)
    Protein H27M09.5
    (see all 3)
    4(a)
    4(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    I(4554151-4555204)
    I(6845179-6846953)


    ENSEMBL Gene Tree for SRSF11 (if available)
    TreeFam Gene Tree for SRSF11 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF11 gene
    SREK12  LUC7L2  RSRC22  LUC7L32  ZC3H132  LUC7L22  PNISR2  RBM252  
    PRPF38B2  TRAF3IP12  
    6 SIMAP similar genes for SRSF11 using alignment to 5 protein entries:     SRS11_HUMAN (see all proteins):
    SFRS11    DKFZp686P22142    DKFZp686D02116    DKFZp686M13204    SREK1    DKFZp667P103

    SRSF11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SRSF11
    PGOHUM00000239698


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/690 NCBI SNPs in SRSF11 are shown (see all 690    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774544341,2
    C--70669456(+) AGCACA/GACCCC 3 -- int1 us2k10--------
    rs1134018671,2
    C--70669554(+) CAGAC-/AGAG  
            
    AAAGA
    3 -- us2k1 int11Minor allele frequency- AGAG:0.00CSA 2
    rs37538171,2
    C,F,H--70669613(-) ATGGTA/GTTTGT 3 -- us2k1 int119Minor allele frequency- G:0.16NS EA NA WA CSA 2343
    rs1917573561,2
    --70669748(+) TCCATA/GTCATC 3 -- us2k1 int10--------
    rs1851990591,2
    --70669878(+) ACTTAC/TTGCTT 3 -- int1 us2k10--------
    rs5745871,2
    C,F,H--70669977(+) TCATGG/ATATTA 3 -- int1 us2k118Minor allele frequency- A:0.04NS NA WA CSA EA 1154
    rs1900479371,2
    --70670047(+) ATAAAC/TGCTGT 3 -- us2k1 int10--------
    rs1436979711,2
    --70670061(+) AAAATC/TAAACA 3 -- us2k1 int10--------
    rs1481493011,2
    --70670142(+) CCAAGC/TAGATA 3 -- us2k1 int10--------
    rs1419393641,2
    --70670228(+) TTCTGC/TGTCTT 3 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for SRSF11 (70671365 - 70718735 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SRSF11: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF11
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SRSF11 for disorders           About GeneDecksing

    OMIM gene information: 602010    OMIM disorders: --

    4 diseases for SRSF11:    About MalaCards
    dna topoisomerase i    frontotemporal dementia    dementia    malaria

    Human Genome Epidemiology (HuGE) Navigator: SRSF11 (0 documents)

    Export disorders for SRSF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF11 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with SRSF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. (PubMed id 1896467)1, 2, 3, 9 Chaudhary N.... Blobel G. (1991)
    2. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. PUF60: a novel U2AF65-related splicing activity. (PubMed id 10606266)1, 2 Page-McCaw P.S.... Sharp P.A. (1999)
    5. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)1, 9 Sakashita E.... Mayeda A. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere s hortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9295 HGNC: 10782 AceView: SFRS11 Ensembl:ENSG00000116754 euGenes: HUgn9295
    ECgene: SRSF11 H-InvDB: SRSF11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRSF11 gene:
    Search GeneIP for patents involving SRSF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SRSF11  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRSF11   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRSF11  
     OriGene Protein Over-expression Lysate for SRSF11   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SRSF11   OriGene 3'-UTR Clone for SRSF11  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF11   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRSF11  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRSF11   OriGene Custom Protein Services for SRSF11  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRSF11
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF11
     GenScript Custom Purified and Recombinant Proteins Services for SRSF11 GenScript cDNA clones with any tag delivered in your preferred vector for SRSF11
     GenScript Custom Assay Services for SRSF11 GenScript Custom Superior Antibodies Services for SRSF11
     GenScript Custom overexpressing Cell Line Services for SRSF11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for SRSF11
     Search Chromatin IP Primers for SRSF11
     RT2 qPCR Primer Assay in human, mouse, rat SRSF11
     Search GNC Networks for SRSF11
     SABiosciences Custom PCR Arrays for SRSF11
     Search Tocris compounds for SRSF11
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SRSF11 antibodies
     SRSF11 lysates
     Antibodies for SRSF11
     See all of Abcam's Antibodies, Kits and Proteins for SRSF11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SRSF11 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SRSF11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF11
     SwitchGear 3'UTR luciferase reporter plasmids for SRSF11
     SwitchGear Promoter luciferase reporter plasmids for SRSF11
     Search ThermoFisher Antibodies for SRSF11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF11
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SRSF11
    Sirion Biotech Customized:
     stable knockdown cell line services for SRSF11
     inducible knockdown cell line services for SRSF11
     design and validation of potent shRNA sequences against SRSF11
     adenovirus for potent knockdown of SRSF11
     adenovirus for overexpression of SRSF11
     stable overexpressing cell line services for SRSF11
     inducible overexpressing cell line services for SRSF11
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRSF11 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4