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SRSF11 Gene

protein-coding   GIFtS: 54
GCID: GC01P070672

Serine/Arginine-Rich Splicing Factor 11

(Previous names: splicing factor, arginine/serine-rich 11)
(Previous symbol: SFRS11)
  Search for SRSF11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine-Rich Splicing Factor 111 2     p542 3
SFRS111 2 3 5     NET22
Splicing Factor, Arginine/Serine-Rich 111 2 3     dJ677H15.22
SR Splicing Factor 111 2     Splicing Factor P542
Arginine-Rich 54 KDa Nuclear Protein2 3     

External Ids:    HGNC: 107821   Entrez Gene: 92952   Ensembl: ENSG000001167547   OMIM: 6020105   UniProtKB: Q055193   

Export aliases for SRSF11 gene to outside databases

Previous GC identifer: GC01P068782


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRSF11 Gene:
This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in
pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and
immunolocalization data suggest that it may play a role in pre-mRNA processing. Alternative splicing results in
multiple transcript variants encoding different proteins. In addition, a pseudogene of this gene has been found
on chromosome 12.(provided by RefSeq, Sep 2010)

GeneCards Summary for SRSF11 Gene:
SRSF11 (serine/arginine-rich splicing factor 11) is a protein-coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SREK1.

UniProtKB/Swiss-Prot: SRS11_HUMAN, Q05519
Function: May function in pre-mRNA splicing

Gene Wiki entry for SRSF11 (SFRS11) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SRSF11
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRSF11 promoter sequence
   Search Chromatin IP Primers for SRSF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRSF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

SRSF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P070672:  view genomic region     (about GC identifiers)

Start:
70,671,365 bp from pter      End:
70,718,735 bp from pter
Size:
47,371 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRS11_HUMAN, Q05519 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 11  
Size: 484 amino acids; 53542 Da
Subunit: Interacts with PUF60
Secondary accessions: Q5T758 Q8IWE6
Alternative splicing: 2 isoforms:  Q05519-1   Q05519-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF11: NX_Q05519

Explore proteomics data for SRSF11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys58, Lys82, Lys197
  • Modification sites at PhosphoSitePlus

  • See SRSF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177916.1  NP_004759.1  

    ENSEMBL proteins: 
     ENSP00000359989   ENSP00000359988   ENSP00000474372   ENSP00000378568   ENSP00000474149  
     ENSP00000359987   ENSP00000384357   ENSP00000405120   ENSP00000411159  
    Reactome Protein details: Q05519

    SRSF11 Human Recombinant Protein Products:

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    Novus Biologicals SRSF11 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRSF11

     
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    Cloud-Clone Corp. ELISAs for SRSF11
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    Search eBioscience for ELISAs for SRSF11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q05519

    ProtoNet protein and cluster: Q05519

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRS11_HUMAN, Q05519
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with SRSF11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRS11_HUMAN, Q05519
    Function: May function in pre-mRNA splicing

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRSF11           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRSF11
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRSF11

    miRNA
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    miRTarBase miRNAs that target SRSF11:
    hsa-mir-423-5p (MIRT038024), hsa-mir-186-5p (MIRT045297), hsa-mir-376a-5p (MIRT004025), hsa-mir-21-5p (MIRT030735), hsa-mir-376a-3p (MIRT019666)

    Block miRNA regulation of human, mouse, rat SRSF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRSF11 (see all 20):
    hsa-miR-148b hsa-miR-24-1* hsa-miR-509-5p hsa-miR-138-2* hsa-miR-24-2* hsa-miR-548g hsa-miR-205* hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidSRSF11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRSF11

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF11 (NM_004768)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF11

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRS11_HUMAN, Q05519: Nucleus. Note=Colocalizes with spliceosome components
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with SRSF11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRSF11 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    2mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SRSF11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for SRSF11
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRSF11
    Interactions:

        Search GeneGlobe Interaction Network for SRSF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRSF11 (Q055191, 2, 3 ENSP000003599884) via UniProtKB, MINT, STRING, and/or I2D (see all 708)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149211, 3, ENSP000003764364EBI-1051785,EBI-913209 I2D: score=1 STRING: ENSP00000376436
    PUF60Q9UHX12, 3, ENSP000003220164MINT-7945693 I2D: score=4 STRING: ENSP00000322016
    SRSF1Q079552, 3, ENSP000002589624MINT-7945693 I2D: score=3 STRING: ENSP00000258962
    SRSF2Q011302, 3, ENSP000003508774MINT-7945693 I2D: score=3 STRING: ENSP00000350877
    U2AF2P263682, 3, ENSP000003078634MINT-7945693 I2D: score=3 STRING: ENSP00000307863
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing TAS1896467
    GO:0006406mRNA export from nucleus TAS--

    Find genes that share ontologies with SRSF11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRSF11 (SRS11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRSF11 gene (2 alternative transcripts): 
    NM_001190987.1  NM_004768.3  

    Unigene Cluster for SRSF11:

    Serine/arginine-rich splicing factor 11
    Hs.479693  [show with all ESTs]
    Unigene Representative Sequence: BX640645
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000370951(uc009wbi.3) ENST00000463877 ENST00000370950(uc001det.3 uc001des.3)
    ENST00000475204 ENST00000395136(uc001deu.2) ENST00000473950 ENST00000469170
    ENST00000486667 ENST00000481648 ENST00000463116 ENST00000484162(uc001dev.3)
    ENST00000370949(uc001dew.3) ENST00000463859 ENST00000460795 ENST00000461935
    ENST00000489188 ENST00000405432 ENST00000436161
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRSF11 (see all 20):
    hsa-miR-148b hsa-miR-24-1* hsa-miR-509-5p hsa-miR-138-2* hsa-miR-24-2* hsa-miR-548g hsa-miR-205* hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidSRSF11 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene clones in human, mouse for SRSF11 (see all 14)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF11 (NM_004768)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF11
    Primer
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    OriGene qPCR primer pairs and template standards for SRSF11
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRSF11
      QuantiTect SYBR Green Assays in human, mouse, rat SRSF11
      QuantiFast Probe-based Assays in human, mouse, rat SRSF11

    Additional mRNA sequence: 

    AB062486.1 AK300147.1 AK301670.1 AK310447.1 AK310666.1 AK311184.1 AL832279.1 BC002784.2 
    BC009840.2 BC017359.2 BC022815.1 BC032727.1 BC040436.1 BX537679.1 BX640645.1 BX641004.1 
    M74002.1 

    Selected DOTS entries (see all 39):

    DT.441504  DT.219368  DT.101985035  DT.92458648  DT.95258238  DT.100875482  DT.219363  DT.100731211 
    DT.40276859  DT.92057476  DT.85104163  DT.97767765  DT.97856065  DT.121411784  DT.121411659  DT.95258218 
    DT.95258224  DT.95258244  DT.100677405  DT.100892579  DT.121411748  DT.121411759  DT.95258245  DT.100059238 

    Selected AceView cDNA sequences (see all 648):

    BG571712 AI146826 AA670045 BE887320 AA683543 AW572522 AL704211 W94637 
    AA362943 BP366034 AI701320 BM837585 AW152161 CA389446 AU138208 BE219407 
    AI379306 AI401804 BF984926 AA333395 BM971164 BE222276 CD687770 AA313886 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRSF11 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^
    SP1:                                      -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP2:                    -     -           -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP3:                    -     -     -     -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP4:                    -     -           -                 -     -     -     -     -     -     -     -     -     -     -                                       
    SP5:                                                                                                                    -                                       

    ExUns: 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for SRSF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRSF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGATGTACA
    SRSF11 Expression
    About this image


    SRSF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    SRSF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRSF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479693
        Custom PCR Arrays for SRSF11
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SRSF11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRSF11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf111 , 5 serine/arginine-rich splicing factor 111, 5 88.64(n)1
    97.57(a)1
      3 (81.63 cM)5
    692071  NM_001093753.11  NP_001087222.11 
     1580104735 
    chicken
    (Gallus gallus)
    Aves SRSF116
    Gallus gallus serine/arginine-rich splicing factor...
    95(a)
    1 ↔ 1
    8(27913700-27925763)
    lizard
    (Anolis carolinensis)
    Reptilia SRSF116
    serine/arginine-rich splicing factor 11
    91(a)
    1 ↔ 1
    GL343328.1(1161225-1191929)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.348222 Xenopus laevis transcribed sequence with moderate similarity more 80.2(n)    CA971280.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb37g022 wufb37g02 73.71(n)   321886  BC044186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Srp546
    Srp54
    31(a)
    1 → many
    2L(9912911-9915044)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-76
    Protein RSP-7, isoform a (rsp-7) mRNA, complete cd...
    30(a)
    1 → many
    II(10659208-10662315) WBGene00004704


    ENSEMBL Gene Tree for SRSF11 (if available)
    TreeFam Gene Tree for SRSF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRSF11 gene
    SREK12  
    6 SIMAP similar genes for SRSF11 using alignment to 6 protein entries:     SRS11_HUMAN (see all proteins):
    SFRS11    DKFZp686P22142    DKFZp686D02116    DKFZp686M13204    SREK1    DKFZp667P103

    Find genes that share paralogs with SRSF11           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SRSF11
    PGOHUM00000239698


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRSF11 (see all 799)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021609551,2
    C--70673408(+) CGTTC-/TTTTTT 2 -- int10--------
    rs1916980471,2
    --70673494(+) ACCTCA/GAAATC 2 -- int10--------
    rs781483211,2
    C--70673549(+) CACACC/TACCAT 2 -- int10--------
    rs1816835981,2
    --70673692(+) AAGCAA/GTCCTT 2 -- int10--------
    rs1865329041,2
    --70673700(+) CTTCTA/GTCTGG 2 -- int10--------
    rs1452446361,2
    --70673820(+) TAAATA/GTTTCA 2 -- int10--------
    rs1491917951,2
    C--70673974(+) CATATA/GTAAGA 2 -- int10--------
    rs1123435891,2
    C--70674008(+) GTATG-/GTGT  
     
    /GTGTGT
    GTGTG
    4 -- int1 cds11CSA 2
    rs1416541851,2
    C--70674009(+) GTATG-/GT/   
      GTGTGT
    GTGTG
    4 -- int1 cds10--------
    rs46500321,2
    --70674017(+) tgtgtA/Gtgtgt 2 -- int10--------

    HapMap Linkage Disequilibrium report for SRSF11 (70671365 - 70718735 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SRSF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671094CNV Deletion23128226
    nsv1343CNV Insertion18451855
    nsv870841CNV Loss21882294
    nsv871898CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRSF11
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602010    OMIM disorders: --


    Find genes that share disorders with SRSF11           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SRSF11 (0 documents)

    Export disorders for SRSF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRSF11 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with SRSF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. (PubMed id 1896467)1, 2, 3, 9 Chaudhary N.... Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (amp 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. PUF60: a novel U2AF65-related splicing activity. (PubMed id 10606266)1, 2 Page-McCaw P.S.... Sharp P.A. (RNA 1999)
    5. Human RNPS1 and its associated factors: a versatile alternative pre- mRNA splicing regulator in vivo. (PubMed id 14729963)1, 9 Sakashita E.... Mayeda A. (Mol. Cell. Biol. 2004)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PubMed id 22379092)1 Shamay M....Hayward S.D. (J. Virol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9295 HGNC: 10782 AceView: SFRS11 Ensembl:ENSG00000116754 euGenes: HUgn9295
    ECgene: SRSF11 H-InvDB: SRSF11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRSF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SRSF11 gene:
    Search GeneIP for patents involving SRSF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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