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Aliases for SRSF10 Gene

Aliases for SRSF10 Gene

  • Serine/Arginine-Rich Splicing Factor 10 2 3
  • Splicing Factor, Arginine/Serine-Rich 13A 2 3 4
  • FUSIP1 3 4 6
  • TASR 3 4 6
  • FUS-Interacting Protein (Serine-Arginine Rich) 2 2 3
  • TLS-Associated Protein With Ser-Arg Repeats 3 4
  • TLS-Associated Protein With SR Repeats 3 4
  • 40 KDa SR-Repressor Protein 3 4
  • Neural-Salient SR Protein 2 3
  • TLS-Associated SR Protein 3 4
  • SR Splicing Factor 10 2 3
  • Splicing Factor SRp38 3 4
  • SFRS13A 3 4
  • FUSIP2 3 4
  • SRrp40 3 4
  • TASR1 3 6
  • TASR2 3 6
  • FUS Interacting Protein (Serine/Arginine-Rich) 1 2
  • FUS Interacting Protein (Serine-Arginine Rich) 1 3
  • FUS-Interacting Serine-Arginine-Rich Protein 1 4
  • Protein Phosphatase 1, Regulatory Subunit 149 3
  • Serine-Arginine Repressor Protein (40 KDa) 3
  • TLS-Associated Serine-Arginine Protein 1 3
  • TLS-Associated Serine-Arginine Protein 2 3
  • Splicing Factor, Arginine/Serine-Rich 13 3
  • TLS-Associated Serine-Arginine Protein 4
  • TLS-Associated Protein TASR 3
  • Arginine/Serine-Rich 13 2
  • Regulatory Subunit 149 2
  • Protein Phosphatase 1 2
  • Splicing Factor 2
  • PPP1R149 3
  • SFRS13 3
  • SRp38 3
  • NSSR 3

External Ids for SRSF10 Gene

Previous HGNC Symbols for SRSF10 Gene

  • FUSIP2
  • FUSIP1
  • SFRS13A

Previous GeneCards Identifiers for SRSF10 Gene

  • GC01M024293

Summaries for SRSF10 Gene

Entrez Gene Summary for SRSF10 Gene

  • This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for SRSF10 Gene

SRSF10 (Serine/Arginine-Rich Splicing Factor 10) is a Protein Coding gene. Among its related pathways are Spliceosome and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and unfolded protein binding. An important paralog of this gene is SRSF2.

UniProtKB/Swiss-Prot for SRSF10 Gene

  • Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.

Gene Wiki entry for SRSF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF10 Gene

Genomics for SRSF10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRSF10 Gene

Start:
23,964,804 bp from pter
End:
23,980,927 bp from pter
Size:
16,124 bases
Orientation:
Minus strand

Genomic View for SRSF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF10 Gene

No data available for Regulatory Elements for SRSF10 Gene

Proteins for SRSF10 Gene

  • Protein details for SRSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75494-SRS10_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 10
    Protein Accession:
    O75494
    Secondary Accessions:
    • A6NFM6
    • A6NI42
    • A6NIU7
    • B4DJP9
    • O60572
    • Q5JRH9
    • Q5JRI0
    • Q5JRI2
    • Q5JRI3
    • Q5JRI4
    • Q96G09
    • Q96P17

    Protein attributes for SRSF10 Gene

    Size:
    262 amino acids
    Molecular mass:
    31301 Da
    Quaternary structure:
    • The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated form interacts with SNRNP70. Isoform 1 and isoform 3 interact with FUS C-terminus.

    Alternative splice isoforms for SRSF10 Gene

neXtProt entry for SRSF10 Gene

Proteomics data for SRSF10 Gene at MOPED

Post-translational modifications for SRSF10 Gene

  • Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. Isoform 3 is phosphorylated on Ser-168 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SRSF10 Gene

Domains for SRSF10 Gene

Gene Families for SRSF10 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • SRSF :Serine/arginine-rich splicing factors

Protein Domains for SRSF10 Gene

Suggested Antigen Peptide Sequences for SRSF10 Gene

Graphical View of Domain Structure for InterPro Entry

O75494

UniProtKB/Swiss-Prot:

SRS10_HUMAN :
  • O75494
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF10: view

Function for SRSF10 Gene

Molecular function for SRSF10 Gene

UniProtKB/Swiss-Prot Function:
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.

Gene Ontology (GO) - Molecular Function for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 9774382
GO:0005515 protein binding IPI 9774382
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRSF10: view
genes like me logo Genes that share phenotypes with SRSF10: view

Animal Models for SRSF10 Gene

MGI Knock Outs for SRSF10:

Animal Model Products

CRISPR Products

miRNA for SRSF10 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRSF10 Gene

Localization for SRSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF10 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF10 Gene COMPARTMENTS Subcellular localization image for SRSF10 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 9774382
GO:0005654 nucleoplasm IDA 11684676
GO:0005737 cytoplasm NAS 11684676
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with SRSF10: view

Pathways for SRSF10 Gene

SuperPathways for SRSF10 Gene

Superpath Contained pathways
1 Spliceosome
2 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SRSF10: view

Pathways by source for SRSF10 Gene

1 BioSystems pathway for SRSF10 Gene
1 KEGG pathway for SRSF10 Gene

Gene Ontology (GO) - Biological Process for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000244 spliceosomal tri-snRNP complex assembly NAS 11684676
GO:0000375 RNA splicing, via transesterification reactions IDA 9774382
GO:0000398 mRNA splicing, via spliceosome IDA 9774382
GO:0006355 regulation of transcription, DNA-templated NAS 9774382
GO:0006376 mRNA splice site selection IDA 9774382
genes like me logo Genes that share ontologies with SRSF10: view

Transcripts for SRSF10 Gene

Unigene Clusters for SRSF10 Gene

Serine/arginine-rich splicing factor 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRSF10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: -
SP13: - - - -
SP14:
SP15: -
SP16: - - - - - - -
SP17: -
SP18: -
SP19:
SP20:

ExUns: 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1:
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - -
SP9:
SP10:
SP11: - - - - -
SP12:
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for SRSF10 Gene

GeneLoc Exon Structure for
SRSF10
ECgene alternative splicing isoforms for
SRSF10

Expression for SRSF10 Gene

mRNA expression in normal human tissues for SRSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SRSF10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), Nasal epithelium (7.5), and Fetal ovary (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF10 Gene

SOURCE GeneReport for Unigene cluster for SRSF10 Gene Hs.3530

mRNA Expression by UniProt/SwissProt for SRSF10 Gene

O75494-SRS10_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with SRSF10: view

Expression partners for SRSF10 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SRSF10 Gene

Orthologs for SRSF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SRSF10 35
  • 96.82 (n)
  • 99.62 (a)
-- 36
  • 67 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srsf10 35
  • 94.53 (n)
  • 100 (a)
Srsf10 16
Srsf10 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SFRS13A 35
  • 99.75 (n)
  • 100 (a)
SFRS13A 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FUSIP1 36
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves SRSF10 35
  • 90.08 (n)
  • 97.71 (a)
GGA.8379 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf10 35
  • 71.45 (n)
  • 77.52 (a)
Str.1085 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53149 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
si:ch211-135d14.5 36
  • 58 (a)
ManyToMany
zgc:65772 36
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta SC35 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 36
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11150 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4661 36
  • 49 (a)
OneToMany
Species with no ortholog for SRSF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF10 Gene

ENSEMBL:
Gene Tree for SRSF10 (if available)
TreeFam:
Gene Tree for SRSF10 (if available)

Paralogs for SRSF10 Gene

Paralogs for SRSF10 Gene

Selected SIMAP similar genes for SRSF10 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SRSF10 Gene

genes like me logo Genes that share paralogs with SRSF10: view

Variants for SRSF10 Gene

Sequence variations from dbSNP and Humsavar for SRSF10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3806170 -- 23,980,531(-) AAGAG(G/T)CACCG upstream-variant-2KB
rs3806171 -- 23,980,360(+) TCGGT(A/C/G/T)GCCGT utr-variant-5-prime, nc-transcript-variant, upstream-variant-2KB
rs4276860 -- 23,967,759(+) GGTTT(C/T)CTTTA utr-variant-3-prime, intron-variant
rs4532777 -- 23,979,564(+) AATGA(C/T)TGACG intron-variant, upstream-variant-2KB
rs4649147 -- 23,975,231(+) TTCAG(C/T)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRSF10 Gene

Variant ID Type Subtype PubMed ID
esv2676255 CNV Deletion 23128226
esv2662136 CNV Deletion 23128226

Relevant External Links for SRSF10 Gene

HapMap Linkage Disequilibrium report
SRSF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRSF10 Gene

Disorders for SRSF10 Gene

No disorders were found for SRSF10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SRSF10 Gene

Publications for SRSF10 Gene

  1. Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins. (PMID: 11891055) Clinton J.M. … Yang L. (Gene 2002) 2 3 4 23
  2. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. (PMID: 9774382) Yang L. … Hickstein D.D. (J. Biol. Chem. 1998) 3 4 23
  3. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. (PMID: 10779324) Yang L. … Hickstein D.D. (Mol. Cell. Biol. 2000) 3 4 23
  4. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PMID: 11684676) Cowper A.E. … Screaton G.R. (J. Biol. Chem. 2001) 3 4 23
  5. The SR protein SRp38 represses splicing in M Phase cells. (PMID: 12419250) Shin C. … Manley J.L. (Cell 2002) 3 4

Products for SRSF10 Gene

Sources for SRSF10 Gene

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