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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SRSF10 Gene

protein-coding GIFtS: 55
GCID: GC01M024293

serine/arginine-rich splicing factor 10

(Previous names: FUS-interacting protein (serine-arginine rich) 2, FUS interacting...)
(Previous symbols: FUSIP2, FUSIP1, SFRS13A)

Explore 6 diseases affiliated with
SRSF10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 10¹ ²		40 KDa SR-Repressor Protein² ³
FUSIP1¹ ² ³ ⁵		FUS-Interacting Serine-Arginine-Rich Protein 1² ³
Splicing Factor, Arginine/Serine-Rich 13A¹ ² ³		TLS-Associated Protein With Ser-Arg Repeats² ³
FUSIP2¹ ² ³		TLS-Associated Protein With SR Repeats² ³
SFRS13A¹ ² ³		TLS-Associated SR Protein² ³
SRrp40¹ ² ³		FUS Interacting Protein (Serine/Arginine-Rich) 1¹
TASR1¹ ² ⁵		FUS Interacting Protein (Serine-Arginine Rich) 1²
TASR2¹ ² ⁵		Serine-Arginine Repressor Protein (40 KDa)²
TASR² ³ ⁵		Splicing Factor, Arginine/Serine-Rich 13²
NSSR¹ ²		SR Splicing Factor 10²
SFRS13¹ ²		TLS-Associated Protein TASR²
SRp38¹ ²		TLS-Associated Serine-Arginine Protein 1²
FUS-Interacting Protein (Serine-Arginine Rich) 2¹ ²		TLS-Associated Serine-Arginine Protein 2²
Neural-Salient SR Protein¹ ²		TLS-Associated Serine-Arginine Protein³
Splicing Factor SRp38² ³

External Ids:	HGNC: 16713¹	Entrez Gene: 10772²	Ensembl: ENSG00000188529⁷	OMIM: 605221⁵	UniProtKB: O75494³

ORGUL members:
	NONCODE:n409650

Export aliases for SRSF10 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF10:

This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and

regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are

required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with

other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts

with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple

pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In

addition, transcript variants utilizing alternative polyA sites exist.(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494

Function: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to

interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and

after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a

positive and isoform 3 as a negative regulator

Gene Wiki entry for SRSF10 (FUSIP1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SRSF10
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRSF10 promoter sequence

Search SABiosciences Chromatin IP Primers for SRSF10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11

SRSF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF10 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M024293: view genomic region (about GC identifiers)

Start:	24,291,294 bp from pter	End:	24,307,417 bp from pter
Size:	16,124 bases	Orientation:	minus strand

1 alternative location:

Chr1-,GL000191.1 36,277-50,281

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494 (See protein sequence)

Recommended Name: Serine/arginine-rich splicing factor 10

Size: 262 amino acids; 31301 Da

Subunit: The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated form

interacts with SNRNP70. Isoform 1 and isoform 3 interact with FUS C-terminus

Subcellular location: Nucleus speckle. Cytoplasm

Secondary accessions: A6NFM6 A6NI42 A6NIU7 B4DJP9 O60572 Q5JRH9 Q5JRI0 Q5JRI2 Q5JRI4 Q96G09 Q96P17

Alternative splicing: 5 isoforms: O75494-1 O75494-2 O75494-3 O75494-4 O75494-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF10: NX_O75494

Post-translational modifications:

Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. Isoform 3 is

phosphorylated on Ser-168 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75494

SRSF10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001177934.1 NP_001177935.1 NP_001177936.1 NP_001177938.1 NP_006616.1 NP_473357.1

ENSEMBL proteins:

ENSP00000419813 ENSP00000342913 ENSP00000363576 ENSP00000363577 ENSP00000420195

ENSP00000344149 ENSP00000388991

Human Recombinant Protein Products:

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	Uscn Proteins for SRSF10

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	9774382
GO:0005654	nucleoplasm	IDA	11684676
GO:0005737	cytoplasm	NAS	11684676
GO:0016607	nuclear speck	IEA	--

SRSF10 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for SRSF10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SRSF10 for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry O75494

ProtoNet protein and cluster: O75494

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494

Similarity: Belongs to the splicing factor SR family

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494

Function: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to

interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and

after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a

positive and isoform 3 as a negative regulator

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		hsa-miR-579 hsa-miR-640 hsa-miR-300 hsa-miR-4275 hsa-miR-4274 hsa-miR-1243 hsa-miR-509-3-5p hsa-miR-409-3p

		SwitchGear 3'UTR luciferase reporter plasmid: SRSF10 3' UTR sequence

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF10

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	NAS	9774382
GO:0005515	protein binding	IPI	9774382
GO:0050733	RS domain binding	NAS	11684676

SRSF10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SRSF10:

Increased S DNA content

Animal Models:
Mouse knock-out Srsf10^tm1Jalm for SRSF10
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Srsf10):

cardiovascular system

growth/size

homeostasis/metabolism

liver/biliary system

mortality/aging

SRSF10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA processing

0.48

Spliceosome

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for SRSF10

mRNA processing

1 Kegg Pathway (Kegg details for SRSF10):

Spliceosome

SRSF10 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SRSF10

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/33 Interacting proteins for SRSF10 (O75494^{2, 3} ENSP00000420195⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³	MINT-3976116 I2D: score=2
FUS	P35637²^,³, ENSP00000254108⁴	MINT-15493 I2D: score=4 STRING: ENSP00000254108
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-50952 I2D: score=3 STRING: ENSP00000300161
YWHAG	P61981²^,³, ENSP00000306330⁴	MINT-50843 I2D: score=4 STRING: ENSP00000306330
SNRNP70	P08621³, ENSP00000221448⁴	I2D: score=2 STRING: ENSP00000221448

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000244	assembly of spliceosomal tri-snRNP	NAS	11684676
GO:0000375	RNA splicing, via transesterification reactions	IDA	9774382
GO:0000398	mRNA splicing, via spliceosome	IDA	9774382
GO:0006355	regulation of transcription, DNA-dependent	NAS	9774382
GO:0006376	mRNA splice site selection	IDA	9774382

SRSF10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SRSF10
Search CenterWatch for drugs/clinical trials and news about SRSF10 / SRS10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SRSF10 gene (6 alternative transcripts):

NM_001191005.1 NM_001191006.1 NM_001191007.1 NM_001191009.1 NM_006625.4 NM_054016.2

Unigene Cluster for SRSF10:

Serine/arginine-rich splicing factor 10

Hs.3530 [show with all ESTs]

Unigene Representative Sequence: AF419331

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484146 ENST00000344989 ENST00000341154(uc021oin.1 uc021oio.1 uc021oip.1 uc001bij.2)

ENST00000473858 ENST00000374452 ENST00000374453 ENST00000492112 ENST00000343255(uc021oir.1 uc021ois.1)

ENST00000485841 ENST00000338597 ENST00000495785 ENST00000467887 ENST00000473754

ENST00000497214 ENST00000485292 ENST00000469303 ENST00000453840(uc021oiq.1)

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		8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF10 (see all 77):
		hsa-miR-579 hsa-miR-640 hsa-miR-300 hsa-miR-4275 hsa-miR-4274 hsa-miR-1243 hsa-miR-509-3-5p hsa-miR-409-3p

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF10

Additional cDNA sequence:

AF047448.1 AF067730.1 AF419331.1 AF449427.1 AK001286.1 AK001479.1 AK001656.1 AK055311.1

AK093226.1 AK222994.1 AK296175.1 AL133655.1 AY007101.1 AY150180.1 AY150181.1 BC001107.1

BC005039.1 BC010074.2 NR_034035.1

24/32 DOTS entries (see all 32):

DT.75103208 DT.214247 DT.100675718 DT.95251380 DT.410761 DT.100835635 DT.100879350 DT.100667960

DT.91767704 DT.100879338 DT.121451001 DT.121451045 DT.100879354 DT.102833123 DT.100735329 DT.91767695

DT.40260746 DT.121200524 DT.121451008 DT.121451046 DT.121451058 DT.87078038 DT.95251384 DT.99967297

24/447 AceView cDNA sequences (see all 447):

BM921276 AA279275 AA713517 BM910977 BQ614240 AW078954 BG940132 BM850053

BQ220979 CA445710 AA491034 AU132812 AW057530 BM839650 AI611747 AA594427

NM_006625 AA465162 AI760410 BE465222 AL706814 CB112315 AA768497 AI016352

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF10 (see all 20) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·
SP1:															-				-		-		-		-		-		-		-		-		-		-				-
SP2:															-				-		-		-		-		-		-		-		-		-		-				-						-		-		-
SP3:															-				-		-		-		-		-		-		-		-		-		-				-						-		-		-
SP4:															-				-		-		-		-		-		-		-		-		-		-				-
SP5:															-				-		-		-		-		-		-		-		-		-		-				-						-		-		-

ExUns:	9d	·	9e	·	9f	·	9g	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f	·	10g
SP1:
SP2:	-		-		-		-		-
SP3:	-		-		-		-		-
SP4:
SP5:	-		-		-		-

ECgene alternative splicing isoforms for SRSF10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SRSF10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGTGTAT

About this image

SRSF10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Right Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SRSF10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRSF10

SOURCE GeneReport for Unigene cluster: Hs.3530

UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for SRSF10

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRSF10 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SFRS13A⁶	FUS interacting protein (serine-arginine rich) 1	97(a)	possible ortholog	23(5891199-5899591)
lizard (Anolis carolinensis)	Reptilia	--	--	89(a)	1 → many	GL343498.1(45826-50279)
African clawed frog (Xenopus laevis)	Amphibia	MGC53149²	similar to FUS interacting protein (serine-arginine more	74.81(n)		BC046695.1
zebrafish (Danio rerio)	Actinopterygii	BC056275.1²	--	69.67(n)		393505 BC056275.1
thale cress (Arabidopsis thaliana)	eudicotyledons	SR33¹	SC35-like splicing factor 33	43.02(n) 43.61(a)		841976 NM_104406.5 NP_564685.4
rice (Oryza sativa)	Liliopsida	Os03g0374575¹	hypothetical protein	49.52(n) 48(a)		9268085 NM_001186514.1 NP_001173443.1

ENSEMBL Gene Tree for SRSF10 (if available)
TreeFam Gene Tree for SRSF10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SRSF10 gene

LOC100996657² SRSF4² SRSF12² SRSF9² SRSF5² SRSF2² SRSF7² SRSF1²

SRSF6² SRSF3²

16 SIMAP similar genes for SRSF10 using alignment to 3 protein entries: SRS10_HUMAN (see all proteins):

FUSIP1 SRSF12 HNRNPA1 PABPC4 SRSF3 SFRS3

SFRS2 SRSF2 SFRS4 SFRS5 LOC346472 LOC392896

CIRBP SRSF8 SRSF5 SRSF7

SRSF10 for paralogs About GeneDecksing

4 Pseudogenes.org Pseudogenes for SRSF10
PGOHUM00000234930 PGOHUM00000247438 PGOHUM00000259906 PGOHUM00000236297

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55690835^1,2	C	--	24292830(+)	`GGAAAA/GTTTTA`	5	--	ds500¹		0	--	--	--	--
rs55992515^1,2	C	--	24292854(+)	`AAAGAC/TGACAA`	5	--	ds500¹		0	--	--	--	--
rs150302572^1,2	C	--	24294451(+)	`GCTTC-/AAAAAA`	5	--	int¹		0	--	--	--	--
rs145191744^1,2		--	24294587(+)	`AGTGGA/GGGACT`	5	--	int¹		0	--	--	--	--
rs116174936^1,2	C,F,	--	24298918(+)	`TTTGGC/TGTCTT`	7	--	int¹		2		WA NA	238
rs138271142^1,2		--	24298931(+)	`TTTTTA/TAATTA`	7	--	int¹		0	--	--	--	--
rs192860193^1,2		--	24299279(+)	`CAGGCC/TGGAGT`	7	--	int¹		0	--	--	--	--
rs147348261^1,2		--	24299280(+)	`AGGCCA/GGAGTG`	7	--	int¹		0	--	--	--	--
rs76783076^1,2	C,	--	24299287(+)	`AGTGCA/GATGGC`	7	--	int¹		2		NA	4
rs78811903^1,2	C	--	24299319(+)	`CTCCGC/TCTCCT`	7	--	int¹		2		NA	4

HapMap Linkage Disequilibrium report for SRSF10 (24291294 - 24307417 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SRSF10: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRSF10

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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SRSF10 for disorders           About GeneDecksing

OMIM gene information: 605221    OMIM disorders: --

6 diseases for SRSF10:    About MalaCards

cryptorchidism liposarcoma colorectal cancer malaria

leukemia neuronitis

Export disorders for SRSF10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SRSF10 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with SRSF10)

Utopia: connect your pdf to the dynamic
world of online information

Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins. (PubMed id 11891055)^{1, 2, 3, 9} Clinton J.M.... Yang L. (2002)
Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. (PubMed id 9774382)^{1, 2, 9} Yang L.... Hickstein D.D. (1998)
Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PubMed id 11684676)^{1, 2, 9} Cowper A.E.... Screaton G.R. (2001)
TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. (PubMed id 10779324)^{1, 2, 9} Yang L.... Hickstein D.D. (2000)
A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)^{1, 3} Manley J.L. and Krainer A.R. (2010)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. (PubMed id 14765198)^{1, 2} Shin C.... Manley J.L. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The SR protein SRp38 represses splicing in M Phase cells. (PubMed id 12419250)^{1, 2} Shin C. and Manley J.L. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10772	HGNC: 16713	AceView: FUSIP1.1	Ensembl:ENSG00000188529	euGenes: HUgn10772
ECgene: SRSF10	Kegg: 10772	H-InvDB: SRSF10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SRSF10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SRSF10 gene
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Patent Information for SRSF10 gene:
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GeneCards and IP:
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SRSF10 Gene

serine/arginine-rich splicing factor 10

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SRSF10 (Gene Symbol)
Serine/Arginine-Rich Splicing Factor 10
FUSIP1
Splicing Factor, Arginine/Serine-Rich 13A
FUSIP2
SFRS13A
SRrp40
TASR1
TASR2
TASR
NSSR
SFRS13
SRp38
FUS-Interacting Protein (Serine-Arginine Rich) 2
Neural-Salient SR Protein
Splicing Factor SRp38
40 KDa SR-Repressor Protein
FUS-Interacting Serine-Arginine-Rich Protein 1
TLS-Associated Protein With Ser-Arg Repeats
TLS-Associated Protein With SR Repeats
TLS-Associated SR Protein
FUS Interacting Protein (Serine/Arginine-Rich) 1
FUS Interacting Protein (Serine-Arginine Rich) 1
Serine-Arginine Repressor Protein (40 KDa)
Splicing Factor, Arginine/Serine-Rich 13
SR Splicing Factor 10
TLS-Associated Protein TASR
TLS-Associated Serine-Arginine Protein 1
TLS-Associated Serine-Arginine Protein 2
TLS-Associated Serine-Arginine Protein

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SRSF10 Gene

serine/arginine-rich splicing factor 10

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