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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF10 Gene

protein-coding   GIFtS: 57
GCID: GC01M024293

Serine/Arginine-Rich Splicing Factor 10

(Previous names: FUS-interacting protein (serine-arginine rich) 2, FUS interacting...)
(Previous symbols: FUSIP2, FUSIP1, SFRS13A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 101 2     TASR12 5
FUSIP11 2 3 5     TASR22 5
Splicing Factor, Arginine/Serine-Rich 13A1 2 3     Arginine/Serine-Rich 131
FUSIP21 2 3     FUS Interacting Protein (Serine/Arginine-Rich) 11
SFRS13A1 2 3     Splicing Factor1
TASR2 3 5     NSSR2
FUS-Interacting Protein (Serine-Arginine Rich) 21 2     SFRS132
Neural-Salient SR Protein1 2     SRp382
SR Splicing Factor 101 2     FUS Interacting Protein (Serine-Arginine Rich) 12
Splicing Factor SRp382 3     Serine-Arginine Repressor Protein (40 KDa)2
40 KDa SR-Repressor Protein2 3     Splicing Factor, Arginine/Serine-Rich 132
SRrp402 3     TLS-Associated Protein TASR2
FUS-Interacting Serine-Arginine-Rich Protein 12 3     TLS-Associated Serine-Arginine Protein 12
TLS-Associated Protein With Ser-Arg Repeats2 3     TLS-Associated Serine-Arginine Protein 22
TLS-Associated Protein With SR Repeats2 3     TLS-Associated Serine-Arginine Protein3
TLS-Associated SR Protein2 3     

External Ids:    HGNC: 167131   Entrez Gene: 107722   Ensembl: ENSG000001885297   OMIM: 6052215   UniProtKB: O754943   
ORGUL members:         
NONCODE14:n409650      

Export aliases for SRSF10 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF10 Gene:
This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive
and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which
are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating
association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A
pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing.
This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants
encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.(provided
by RefSeq, Jul 2010)

GeneCards Summary for SRSF10 Gene: 
SRSF10 (serine/arginine-rich splicing factor 10) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SRSF10 include cryptorchidism, and liposarcoma, and among its related super-pathways are Processing of Capped Intron-Containing Pre-mRNA. GO annotations related to this gene include unfolded protein binding and RNA binding. An important paralog of this gene is LOC100996657.

UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494
Function: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing.
Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in
M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with
isoform 1 acting as a positive and isoform 3 as a negative regulator

Gene Wiki entry for SRSF10 (FUSIP1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF10
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36.11

SRSF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M024293:  view genomic region     (about GC identifiers)

Start:
24,291,294 bp from pter      End:
24,307,417 bp from pter
Size:
16,124 bases      Orientation:
minus strand

1 alternative location:
Chr1-,GL000191.1 36,277-50,281     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 10  
Size: 262 amino acids; 31301 Da
Subunit: The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated
form interacts with SNRNP70. Isoform 1 and isoform 3 interact with FUS C-terminus
Subcellular location: Nucleus speckle. Cytoplasm
Secondary accessions: A6NFM6 A6NI42 A6NIU7 B4DJP9 O60572 Q5JRH9 Q5JRI0 Q5JRI2 Q5JRI3 Q5JRI4
Q96G09 Q96P17
Alternative splicing: 6 isoforms:  O75494-1   O75494-2   O75494-3   O75494-4   O75494-5   O75494-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRSF10: NX_O75494

Explore proteomics data for SRSF10 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. Isoform 3 is
    phosphorylated on Ser-168 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75494

  • SRSF10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRSF10 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001177934.1  NP_001177935.1  NP_001177936.1  NP_001177938.1  NP_006616.1  NP_473357.1  

    ENSEMBL proteins: 
     ENSP00000342913   ENSP00000388991   ENSP00000419813   ENSP00000473293   ENSP00000363576  
     ENSP00000363577   ENSP00000344149   ENSP00000420195   ENSP00000473291  

    Human Recombinant Protein Products for SRSF10: 
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    Cloud-Clone Corp. Proteins for SRSF10 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC9774382
    GO:0005654nucleoplasm IDA11684676
    GO:0005737cytoplasm NAS11684676
    GO:0016607nuclear speck IEA--

    SRSF10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry O75494

    ProtoNet protein and cluster: O75494

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    SRSF10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRS10_HUMAN, O75494
    Function: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing.
    Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in
    M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with
    isoform 1 acting as a positive and isoform 3 as a negative regulator

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding NAS9774382
    GO:0005515protein binding IPI9774382
    GO:0050733RS domain binding NAS11684676
         
    SRSF10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SRSF10:
     Increased S DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srsf10):
     cardiovascular system  growth/size  homeostasis/metabolism  liver/biliary system  mortality/aging 

    SRSF10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srsf10tm1Jalm for SRSF10

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    miRNA
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    miRTarBase miRNAs that target SRSF10:
    hsa-mir-29c (MIRT003994)

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    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF10 (see all 77):
    hsa-miR-579 hsa-miR-640 hsa-miR-300 hsa-miR-4275 hsa-miR-4274 hsa-miR-1243 hsa-miR-509-3-5p hsa-miR-409-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRSF10 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRSF10 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.46
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRSF10
        mRNA processing


    1         Kegg Pathway  (Kegg details for SRSF10):
        Spliceosome


    SRSF10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/33 Interacting proteins for SRSF10 (O754942, 3 ENSP000004201954) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3976116 I2D: score=2 
    FUSP356372, 3, ENSP000002541084MINT-15493 I2D: score=4 STRING: ENSP00000254108
    YWHABP319462, 3, ENSP000003001614MINT-50952 I2D: score=3 STRING: ENSP00000300161
    YWHAGP619812, 3, ENSP000003063304MINT-50843 I2D: score=4 STRING: ENSP00000306330
    SNRNP70P086213, ENSP000002214484I2D: score=2 STRING: ENSP00000221448
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000244assembly of spliceosomal tri-snRNP NAS11684676
    GO:0000375RNA splicing, via transesterification reactions IDA9774382
    GO:0000398mRNA splicing, via spliceosome IDA9774382
    GO:0006355regulation of transcription, DNA-dependent NAS9774382
    GO:0006376mRNA splice site selection IDA9774382

    SRSF10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF10 (SRS10)

    Search CenterWatch for drugs/clinical trials and news about SRSF10 / SRS10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRSF10 gene (6 alternative transcripts): 
    NM_001191005.1  NM_001191006.1  NM_001191007.1  NM_001191009.1  NM_006625.4  NM_054016.2  

    Unigene Cluster for SRSF10:

    Serine/arginine-rich splicing factor 10
    Hs.3530  [show with all ESTs]
    Unigene Representative Sequence: AF419331
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344989 ENST00000453840(uc021oiq.1) ENST00000341154(uc021oin.1 uc021oio.1 uc021oip.1 uc001bij.2)
    ENST00000484146 ENST00000473858 ENST00000374452 ENST00000374453 ENST00000343255(uc021oir.1 uc021ois.1)
    ENST00000492112 ENST00000485841 ENST00000338597 ENST00000495785 ENST00000473754
    ENST00000497214 ENST00000485292 ENST00000469303
    miRNA
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    8/77 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF10 (see all 77):
    hsa-miR-579 hsa-miR-640 hsa-miR-300 hsa-miR-4275 hsa-miR-4274 hsa-miR-1243 hsa-miR-509-3-5p hsa-miR-409-3p
    SwitchGear 3'UTR luciferase reporter plasmidSRSF10 3' UTR sequence
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    Additional mRNA sequence: 

    AF047448.1 AF067730.1 AF419331.1 AF449427.1 AK001286.1 AK001479.1 AK001656.1 AK055311.1 
    AK093226.1 AK222994.1 AK296175.1 AL133655.1 AY007101.1 AY150180.1 AY150181.1 BC001107.1 
    BC005039.1 BC010074.2 NR_034035.1 

    24/32 DOTS entries (see all 32):

    DT.75103208  DT.214247  DT.100675718  DT.95251380  DT.410761  DT.100835635  DT.100879350  DT.100667960 
    DT.91767704  DT.100879338  DT.121451001  DT.121451045  DT.100879354  DT.102833123  DT.100735329  DT.91767695 
    DT.40260746  DT.121200524  DT.121451008  DT.121451046  DT.121451058  DT.87078038  DT.95251384  DT.99967297 

    24/447 AceView cDNA sequences (see all 447):

    AK055311 AA813871 AA598820 AI003721 AF067730 BG472234 CA446224 Z38297 
    BX367984 AA609115 BE295413 BQ772333 AF449427 AA452853 BC071575 BQ232704 
    AL706815 AI572911 AL046717 BM928059 BU073239 AY007101 BE350679 AY150181 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF10 (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ·
    SP1:                                            -           -     -     -     -     -     -     -     -     -     -           -                                 
    SP2:                                            -           -     -     -     -     -     -     -     -     -     -           -                 -     -     -   
    SP3:                                            -           -     -     -     -     -     -     -     -     -     -           -                 -     -     -   
    SP4:                                            -           -     -     -     -     -     -     -     -     -     -           -                                 
    SP5:                                            -           -     -     -     -     -     -     -     -     -     -           -                 -     -     -   

    ExUns: 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
    SP1:                                                                  
    SP2:  -     -     -     -     -                                       
    SP3:  -     -     -     -     -                                       
    SP4:                                                                  
    SP5:  -     -     -     -                                             


    ECgene alternative splicing isoforms for SRSF10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF10 expression in normal human tissues (normalized intensities)      SRSF10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTGTGTAT
    SRSF10 Expression
    About this image


    SRSF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Left Ventricle
             heart/ventricle/left ventricle   
     
     Limb (Muscoskeletal System)

     -- (Muscoskeletal System)
             mouse/vertebral axis muscle system   

    See SRSF10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF10

    SOURCE GeneReport for Unigene cluster: Hs.3530

    UniProtKB/Swiss-Prot: SRS10_HUMAN, O75494
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRSF10 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf101 , 5 serine/arginine-rich splicing factor 101, 5 94.53(n)1
    100(a)1
      4 (68.01 cM)5
    141051  NM_001080387.11  NP_001073856.11 
     1358557475 
    chicken
    (Gallus gallus)
    Aves --
    Putative uncharacterized protein
    98(a)
    1 → many
    23(5570553-5578945)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    93(a)
    1 → many
    GL343498.1(45826-50279)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC531492 similar to FUS interacting protein (serine-arginine more 74.81(n)    BC046695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056275.12   -- 69.67(n)   393505  BC056275.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SC356
    SC35
    39(a)
    1 → many
    2L(12431075-12434665)
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-46
    Probable splicing factor, arginine/serine-rich 4
    37(a)
    1 → many
    II(5387419-5388830)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SR331 SC35-like splicing factor 33 43.02(n)
    43.61(a)
      841976  NM_104406.5  NP_564685.4 
    rice
    (Oryza sativa)
    Liliopsida Os03g03745751 hypothetical protein 49.52(n)
    48(a)
      9268085  NM_001186514.1  NP_001173443.1 


    ENSEMBL Gene Tree for SRSF10 (if available)
    TreeFam Gene Tree for SRSF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF10 gene
    LOC1009966572  SRSF22  ENSG000002718852  SRSF122  
    15 SIMAP similar genes for SRSF10 using alignment to 3 protein entries:     SRS10_HUMAN (see all proteins):
    FUSIP1    SRSF12    PABPC4    SRSF3    SFRS3    SFRS2
    SRSF2    SFRS4    SFRS5    SRSF8    LOC346472    LOC392896
    CIRBP    TRA2B    SRSF5

    SRSF10 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for SRSF10
    PGOHUM00000234930 PGOHUM00000247438 PGOHUM00000259906 PGOHUM00000236297


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/188 SNPs in SRSF10 are shown (see all 188)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3733856191,2
    C--24292615(+) AAAGAG/TAAACA 5 -- ds50010--------
    rs556908351,2
    C--24292830(+) GGAAAA/GTTTTA 5 -- ds50010--------
    rs559925151,2
    C--24292854(+) AAAGAC/TGACAA 5 -- ds50010--------
    rs3709264941,2
    C--24293612(+) TAATTA/GAATTT 5 -- ut31 nc-transcript-variant0--------
    rs1466303841,2
    C--24294249(+) GGTTTC/TCTTTA 5 -- int1 ut310--------
    rs1453082051,2
    C--24294362(+) CTGGGA/TTGTAA 5 -- int1 ut310--------
    rs1503025721,2
    C--24294451(+) GCTTC-/AAAAAA 5 -- int10--------
    rs1451917441,2
    C--24294587(+) AGTGGA/GGGACT 5 -- int10--------
    rs1152080971,2
    C--24294627(+) CACTAC/TGTAAA 5 -- int10--------
    rs1490616101,2
    C--24295018(+) GAAGA-/AGTA  
            
    GTGAG
    5 -- int10--------

    HapMap Linkage Disequilibrium report for SRSF10 (24291294 - 24307417 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SRSF10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676255CNV Deletion23128226
    esv2662136CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605221    OMIM disorders: --

    5 diseases for SRSF10:    About MalaCards
    cryptorchidism    liposarcoma    colorectal cancer    neuronitis
    leukemia


    SRSF10 for disorders           About GeneDecksing


    Export disorders for SRSF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF10 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with SRSF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins. (PubMed id 11891055)1, 2, 3, 9 Clinton J.M.... Yang L. (2002)
    2. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. (PubMed id 9774382)1, 2, 9 Yang L.... Hickstein D.D. (1998)
    3. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PubMed id 11684676)1, 2, 9 Cowper A.E.... Screaton G.R. (2001)
    4. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. (PubMed id 10779324)1, 2, 9 Yang L.... Hickstein D.D. (2000)
    5. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. (PubMed id 14765198)1, 2 Shin C.... Manley J.L. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The SR protein SRp38 represses splicing in M Phase cells. (PubMed id 12419250)1, 2 Shin C. and Manley J.L. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10772 HGNC: 16713 AceView: FUSIP1.1 Ensembl:ENSG00000188529 euGenes: HUgn10772
    ECgene: SRSF10 Kegg: 10772 H-InvDB: SRSF10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRSF10 gene:
    Search GeneIP for patents involving SRSF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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