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Aliases for SRSF10 Gene

Aliases for SRSF10 Gene

  • Serine/Arginine-Rich Splicing Factor 10 2 3 5
  • Splicing Factor, Arginine/Serine-Rich 13A 2 3 4
  • FUS-Interacting Protein (Serine-Arginine Rich) 2 2 3
  • TLS-Associated Protein With Ser-Arg Repeats 3 4
  • TLS-Associated Protein With SR Repeats 3 4
  • 40 KDa SR-Repressor Protein 3 4
  • Neural-Salient SR Protein 2 3
  • TLS-Associated SR Protein 3 4
  • SR Splicing Factor 10 2 3
  • Splicing Factor SRp38 3 4
  • SFRS13A 3 4
  • FUSIP1 3 4
  • FUSIP2 3 4
  • SRrp40 3 4
  • TASR 3 4
  • FUS Interacting Protein (Serine/Arginine-Rich) 1 2
  • FUS Interacting Protein (Serine-Arginine Rich) 1 3
  • FUS-Interacting Serine-Arginine-Rich Protein 1 4
  • Protein Phosphatase 1, Regulatory Subunit 149 3
  • Serine-Arginine Repressor Protein (40 KDa) 3
  • TLS-Associated Serine-Arginine Protein 1 3
  • TLS-Associated Serine-Arginine Protein 2 3
  • Splicing Factor, Arginine/Serine-Rich 13 3
  • TLS-Associated Serine-Arginine Protein 4
  • TLS-Associated Protein TASR 3
  • Arginine/Serine-Rich 13 2
  • Regulatory Subunit 149 2
  • Protein Phosphatase 1 2
  • Splicing Factor 2
  • PPP1R149 3
  • SFRS13 3
  • SRp38 3
  • TASR1 3
  • TASR2 3
  • NSSR 3

External Ids for SRSF10 Gene

Previous HGNC Symbols for SRSF10 Gene

  • FUSIP2
  • FUSIP1
  • SFRS13A

Previous GeneCards Identifiers for SRSF10 Gene

  • GC01M024293

Summaries for SRSF10 Gene

Entrez Gene Summary for SRSF10 Gene

  • This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for SRSF10 Gene

SRSF10 (Serine/Arginine-Rich Splicing Factor 10) is a Protein Coding gene. Diseases associated with SRSF10 include Liposarcoma. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SRSF8.

UniProtKB/Swiss-Prot for SRSF10 Gene

  • Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.

Gene Wiki entry for SRSF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRSF10 Gene

Genomics for SRSF10 Gene

Regulatory Elements for SRSF10 Gene

Enhancers for SRSF10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SRSF10 on UCSC Golden Path with GeneCards custom track

Promoters for SRSF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRSF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRSF10 Gene

Chromosome:
1
Start:
23,964,347 bp from pter
End:
23,980,927 bp from pter
Size:
16,581 bases
Orientation:
Minus strand

Genomic View for SRSF10 Gene

Genes around SRSF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRSF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRSF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRSF10 Gene

Proteins for SRSF10 Gene

  • Protein details for SRSF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75494-SRS10_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 10
    Protein Accession:
    O75494
    Secondary Accessions:
    • A6NFM6
    • A6NI42
    • A6NIU7
    • B4DJP9
    • O60572
    • Q5JRH9
    • Q5JRI0
    • Q5JRI2
    • Q5JRI3
    • Q5JRI4
    • Q96G09
    • Q96P17

    Protein attributes for SRSF10 Gene

    Size:
    262 amino acids
    Molecular mass:
    31301 Da
    Quaternary structure:
    • The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10. The dephosphorylated form interacts with SNRNP70. Isoform 1 and isoform 3 interact with FUS C-terminus.

    Alternative splice isoforms for SRSF10 Gene

neXtProt entry for SRSF10 Gene

Proteomics data for SRSF10 Gene at MOPED

Post-translational modifications for SRSF10 Gene

  • Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. Isoform 3 is phosphorylated on Ser-168 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRSF10 Gene

Domains & Families for SRSF10 Gene

Protein Domains for SRSF10 Gene

Graphical View of Domain Structure for InterPro Entry

O75494

UniProtKB/Swiss-Prot:

SRS10_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRSF10: view

Function for SRSF10 Gene

Molecular function for SRSF10 Gene

UniProtKB/Swiss-Prot Function:
Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator.

Gene Ontology (GO) - Molecular Function for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SRSF10: view
genes like me logo Genes that share phenotypes with SRSF10: view

Animal Models for SRSF10 Gene

MGI Knock Outs for SRSF10:

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRSF10 Gene

Localization for SRSF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRSF10 Gene

Nucleus speckle. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRSF10 Gene COMPARTMENTS Subcellular localization image for SRSF10 gene
Compartment Confidence
nucleus 5
chloroplast 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA,IDA 11684676
GO:0005737 cytoplasm NAS 11684676
genes like me logo Genes that share ontologies with SRSF10: view

Pathways & Interactions for SRSF10 Gene

SuperPathways for SRSF10 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with SRSF10: view

Pathways by source for SRSF10 Gene

1 BioSystems pathway for SRSF10 Gene
1 KEGG pathway for SRSF10 Gene

Gene Ontology (GO) - Biological Process for SRSF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IDA 9774382
GO:0006406 mRNA export from nucleus NAS 11684676
GO:0016482 cytosolic transport IEA --
genes like me logo Genes that share ontologies with SRSF10: view

No data available for SIGNOR curated interactions for SRSF10 Gene

Drugs & Compounds for SRSF10 Gene

No Compound Related Data Available

Transcripts for SRSF10 Gene

Unigene Clusters for SRSF10 Gene

Serine/arginine-rich splicing factor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRSF10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - -
SP11: - - - - - - - - - - - - - - - - -
SP12: -
SP13: - - - -
SP14:
SP15: -
SP16: - - - - - - -
SP17: -
SP18: -
SP19:
SP20:

ExUns: 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1:
SP2: - - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8: - - - - -
SP9:
SP10:
SP11: - - - - -
SP12:
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for SRSF10 Gene

GeneLoc Exon Structure for
SRSF10
ECgene alternative splicing isoforms for
SRSF10

Expression for SRSF10 Gene

mRNA expression in normal human tissues for SRSF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRSF10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1), Nasal epithelium (7.5), and Fetal ovary (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRSF10 Gene



SOURCE GeneReport for Unigene cluster for SRSF10 Gene Hs.3530

mRNA Expression by UniProt/SwissProt for SRSF10 Gene

O75494-SRS10_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with SRSF10: view

Protein tissue co-expression partners for SRSF10 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for SRSF10 Gene

Orthologs for SRSF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRSF10 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SRSF10 35
  • 96.82 (n)
  • 99.62 (a)
-- 36
  • 67 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srsf10 35
  • 94.53 (n)
  • 100 (a)
Srsf10 16
Srsf10 36
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SFRS13A 35
  • 99.75 (n)
  • 100 (a)
SFRS13A 36
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FUSIP1 36
  • 93 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves SRSF10 35
  • 90.08 (n)
  • 97.71 (a)
GGA.8379 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia srsf10 35
  • 71.45 (n)
  • 77.52 (a)
Str.1085 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53149 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
si:ch211-135d14.5 36
  • 58 (a)
ManyToMany
zgc:65772 36
  • 60 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta SC35 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 36
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11150 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4661 36
  • 49 (a)
OneToMany
Species with no ortholog for SRSF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRSF10 Gene

ENSEMBL:
Gene Tree for SRSF10 (if available)
TreeFam:
Gene Tree for SRSF10 (if available)

Paralogs for SRSF10 Gene

Paralogs for SRSF10 Gene

(15) SIMAP similar genes for SRSF10 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SRSF10 Gene

genes like me logo Genes that share paralogs with SRSF10: view

Variants for SRSF10 Gene

Sequence variations from dbSNP and Humsavar for SRSF10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1136890 -- 23,970,611(-) GAGGC(C/T)GAGGC intron-variant, utr-variant-3-prime
rs3795304 -- 23,971,773(-) TTTGT(A/G)TACTT intron-variant
rs3806170 -- 23,980,531(-) AAGAG(G/T)CACCG upstream-variant-2KB
rs3806171 -- 23,980,360(+) TCGGT(A/C/G/T)GCCGT nc-transcript-variant, utr-variant-5-prime
rs4543740 -- 23,982,422(+) TGATC(C/T)GCCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRSF10 Gene

Variant ID Type Subtype PubMed ID
esv2676255 CNV Deletion 23128226
esv2662136 CNV Deletion 23128226

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for SRSF10 Gene

Disorders for SRSF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRSF10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
liposarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SRSF10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRSF10
genes like me logo Genes that share disorders with SRSF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRSF10 Gene

Publications for SRSF10 Gene

  1. Characterization and expression of the human gene encoding two translocation liposarcoma protein-associated serine-arginine (TASR) proteins. (PMID: 11891055) Clinton J.M. … Yang L. (Gene 2002) 2 3 4 23 67
  2. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). (PMID: 20516191) Manley J.L. … Krainer A.R. (Genes Dev. 2010) 2 3
  3. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. (PMID: 11684676) Cowper A.E. … Screaton G.R. (J. Biol. Chem. 2001) 3 23
  4. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. (PMID: 10779324) Yang L. … Hickstein D.D. (Mol. Cell. Biol. 2000) 3 23
  5. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. (PMID: 9774382) Yang L. … Hickstein D.D. (J. Biol. Chem. 1998) 3 23

Products for SRSF10 Gene

Sources for SRSF10 Gene

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