Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF1 Gene

protein-coding   GIFtS: 65
GCID: GC17M056079

Serine/Arginine-Rich Splicing Factor 1

(Previous names: splicing factor, arginine/serine-rich 1)
(Previous symbol: SFRS1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 11 2     SF22 3
SFRS11 2 3 5     Pre-MRNA-Splicing Factor SF2, P33 Subunit2 3
Splicing Factor, Arginine/Serine-Rich 11 2 3     Alternate Splicing Factor1
Splicing Factor 21 2     P33 Subunit1
SR Splicing Factor 11 2     Pre-MRNA-Splicing Factor SF21
Alternative-Splicing Factor 12 3     SF2p332
ASF2 3     SRp30a2
ASF-12 3     SF2P333

External Ids:    HGNC: 107801   Entrez Gene: 64262   Ensembl: ENSG000001364507   OMIM: 6008125   UniProtKB: Q079553   
ORGUL members:         
NONCODE14:n409655      

Export aliases for SRSF1 gene to outside databases

Previous GC identifer: GC17M051439


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRSF1 Gene:
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both
constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the
spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site.
The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing
factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this
gene. In addition, a pseudogene of this gene has been found on chromosome 13. (provided by RefSeq, Sep 2010)

GeneCards Summary for SRSF1 Gene: 
SRSF1 (serine/arginine-rich splicing factor 1) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SRSF1 include cble, and afibrinogenemia, and among its related super-pathways are mRNA Processing and Post-Elongation Processing of Intron-Containing pre-mRNA. GO annotations related to this gene include RS domain binding and RNA binding. An important paralog of this gene is SRSF5.

UniProtKB/Swiss-Prot: SRSF1_HUMAN, Q07955
Function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative
splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and
3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice
site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or
the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of
the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can
specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors

Gene Wiki entry for SRSF1 (ASF/SF2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRSF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

SRSF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056079:  view genomic region     (about GC identifiers)

Start:
56,078,280 bp from pter      End:
56,084,707 bp from pter
Size:
6,428 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRSF1_HUMAN, Q07955 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 1  
Size: 248 amino acids; 27745 Da
Subunit: Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1
but not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1.
Identified in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with
ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction
is essential for its sequential and processive phosphorylation by SRPK1
Subcellular location: Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the
cytoplasm
4 PDB 3D structures from and Proteopedia for SRSF1:
1X4A (3D)        2M7S (3D)        2O3D (3D)        3BEG (3D)    
Secondary accessions: B2R6Z7 D3DTZ3 Q13809
Alternative splicing: 3 isoforms:  Q07955-1   Q07955-2   Q07955-3   (May be due to intron retention)

Explore the universe of human proteins at neXtProt for SRSF1: NX_Q07955

Explore proteomics data for SRSF1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a
    directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation
    (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive
    phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS
    domain of SRSF1 binds to a docking groove in the large lobe of the kinase domain of SRPK1 and this induces
    certain structural changes in SRPK1 and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate
    phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until
    the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the
    unfolding of the beta-4 motif in RRM 2, which then docks at the docking groove of SRPK1. This also signals RRM 2
    to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed
  • UniProtKB: Arg-97 is dimethylated, probably to asymmetric dimethylarginine
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q07955

  • SRSF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRSF1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001071634.1  NP_008855.1  

    ENSEMBL proteins: 
     ENSP00000462215   ENSP00000462616   ENSP00000463223   ENSP00000463042   ENSP00000462687  
     ENSP00000463917   ENSP00000258962  
    Reactome Protein details: Q07955
    Human Recombinant Protein Products for SRSF1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SRSF1
    OriGene Protein Over-expression Lysate for SRSF1
    OriGene MassSpec for SRSF1 
    OriGene Custom Protein Services for SRSF1
    GenScript Custom Purified and Recombinant Proteins Services for SRSF1
    Novus Biologicals SRSF1 Protein
    Novus Biologicals SRSF1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SRSF1
    Cloud-Clone Corp. Proteins for SRSF1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IDA--
    GO:0035145colocalizes with exon-exon junction complex IDA16314458

    SRSF1 for ontologies           About GeneDecksing



    SRSF1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SRSF1  (SF2)
    OriGene Antibodies for SRSF1
    OriGene Custom Antibody Services for SRSF1
    GenScript Custom Superior Antibodies Services for SRSF1
    Novus Biologicals SRSF1 Antibodies
    Abcam antibodies for SRSF1
    Cloud-Clone Corp. Antibodies for SRSF1 
    ThermoFisher Antibody for SRSF1
    LSBio Antibodies in human, mouse, rat for SRSF1 

    Assay Products for SRSF1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRSF1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRSF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRSF1 
    Cloud-Clone Corp. CLIAs for SRSF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing
    SRSF: Serine/arginine-rich splicing factors

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q07955

    ProtoNet protein and cluster: Q07955

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF1_HUMAN, Q07955
    Domain: The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation
    mechanism of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional
    (C-terminus to N-terminus) phosphorylation reaction in which the RS domain slides through an extended
    electronegative channel separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the
    periphery of the active site and guides the directional phosphorylation mechanism. Both the RS domain and an RRM
    domain are required for nucleocytoplasmic shuttling
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    SRSF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF1_HUMAN, Q07955
    Function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative
    splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and
    3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice
    site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or
    the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of
    the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can
    specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IPI--
    GO:0005515protein binding IPI10196197
    GO:0050733RS domain binding IEA--
         
    SRSF1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SRSF1:
     Decreased viability  Increased gamma-H2AX phosphory  Synthetic lethal with Ras  Synthetic lethal with imatinib 
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Srsf1):
     cardiovascular system  cellular  mortality/aging  muscle  nervous system 
     vision/eye 

    SRSF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Srsf1tm1.1Xdfu for SRSF1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRSF1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRSF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRSF1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRSF1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRSF1:
    hsa-mir-7 (MIRT004497)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF1
    8/174 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF1 (see all 174):
    hsa-miR-124* hsa-miR-579 hsa-miR-576-3p hsa-miR-100* hsa-miR-640 hsa-miR-3938 hsa-miR-376b hsa-miR-517a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRSF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRSF1
    Sirion Biotech Customized adenovirus for overexpression of SRSF1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SRSF1 (see all 15)
    OriGene ORF clones in mouse, rat for SRSF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF1 (NM_006924)
    Sino Biological Human cDNA Clone for SRSF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF1
    Sirion Biotech Customized lentivirus for stable overexpression of SRSF1 
                         Customized lentivirus expression plasmids for stable overexpression of SRSF1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRSF1
    Search LifeMap BioReagents cell lines for SRSF1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SRSF1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Processing of Capped Intron-Containing Pre-mRNA0.85
    mRNA processing0.46
    mRNA Processing0.85
    mRNA Splicing - Minor Pathway0.40
    mRNA Splicing - Major Pathway0.82
    Spliceosome0.31
    mRNA Splicing0.82
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.79
    Post-Elongation Processing of the Transcript0.79
    Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    mRNA 3'-end processing0.79
    Cleavage of Growing Transcript in the Termination Region 0.79
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.85
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SRSF1
        Translational Control

    1 BioSystems Pathway for SRSF1
        mRNA processing


    5/15        Reactome Pathways for SRSF1 (see all 15)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    2         Kegg Pathways  (Kegg details for SRSF1):
        Spliceosome
    Herpes simplex infection


    SRSF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/903 Interacting proteins for SRSF1 (Q079551, 2, 3 ENSP000002589624) via UniProtKB, MINT, STRING, and/or I2D (see all 903)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIDO1Q9BTC02, 3, ENSP000002660704MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000266070
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000221448
    SF3A2Q154282, 3, ENSP000002214944MINT-5205701 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    NPM1P067482, 3, ENSP000002969304MINT-75017 MINT-7947479 I2D: score=1 STRING: ENSP00000296930
    RBM39Q144982, 3, ENSP000002533634MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000253363
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000395mRNA 5'-splice site recognition IDA9885563
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0001701in utero embryonic development IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--

    SRSF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRSF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRSF1

    2 Novoseek inferred chemical compound relationships for SRSF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 43.4 3 10092085 (1), 18853456 (1)
    serine 31.1 1 9611241 (1)

    Search CenterWatch for drugs/clinical trials and news about SRSF1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRSF1 gene (2 alternative transcripts): 
    NM_001078166.1  NM_006924.4  

    Unigene Cluster for SRSF1:

    Serine/arginine-rich splicing factor 1
    Hs.68714  [show with all ESTs]
    Unigene Representative Sequence: NM_001078166
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582730(uc002ivi.3 uc002ivj.3) ENST00000581497 ENST00000584668
    ENST00000581979 ENST00000584773 ENST00000585096 ENST00000583741 ENST00000258962
    ENST00000578430
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF1
    8/174 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF1 (see all 174):
    hsa-miR-124* hsa-miR-579 hsa-miR-576-3p hsa-miR-100* hsa-miR-640 hsa-miR-3938 hsa-miR-376b hsa-miR-517a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRSF1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF1
    Clone
    Products:
         
    OriGene clones in human, mouse for SRSF1 (see all 15)
    OriGene ORF clones in mouse, rat for SRSF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SRSF1 (NM_006924)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRSF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF1
    Sirion Biotech Customized lentivirus for stable overexpression of SRSF1 
                         Customized lentivirus expression plasmids for stable overexpression of SRSF1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SRSF1
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRSF1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF1

    Additional mRNA sequence: 

    AB062124.1 AB209558.1 AK225711.1 AK289933.1 AK298527.1 AK307360.1 AK312781.1 BC010264.1 
    M69040.1 M72709.1 NR_034041.1 

    24/28 DOTS entries (see all 28):

    DT.95317930  DT.100702121  DT.100878381  DT.100683062  DT.95317987  DT.92461044  DT.91996892  DT.120953879 
    DT.308110  DT.100878386  DT.100724456  DT.86841028  DT.120953872  DT.120953824  DT.120953813  DT.120953835 
    DT.120953866  DT.95317845  DT.120953805  DT.40311635  DT.92461026  DT.95317978  DT.120953822  DT.120953864 

    24/814 AceView cDNA sequences (see all 814):

    BQ576202 N39109 AW780169 BM505198 BM995354 NM_006924 CD674524 AW079331 
    AA585258 CD722735 AV708747 BQ228378 BM687926 BM854488 AL042702 AI129616 
    BM704050 BE549761 AW006413 BM456870 BU164586 BU621504 BM145896 AW183627 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                                              -                             -               
    SP2:                                -                             -                                             
    SP3:                                -                             -                             -               
    SP4:                                                              -                                             
    SP5:                                -                             -                                             


    ECgene alternative splicing isoforms for SRSF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF1 expression in normal human tissues (normalized intensities)      SRSF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCGGGATC
    SRSF1 Expression
    About this image


    SRSF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             breast epithelium   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Breast
             breast ; myoepithelial cells   
             breast epithelium   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See SRSF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF1

    SOURCE GeneReport for Unigene cluster: Hs.68714
        SABiosciences Custom PCR Arrays for SRSF1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SRSF1
    OriGene qSTAR qPCR primer pairs in human, mouse for SRSF1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRSF1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRSF1 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srsf11 , 5 serine/arginine-rich splicing factor 11, 5 94.49(n)1
    100(a)1
      11 (52.40 cM)5
    1108091  NM_173374.31  NP_775550.21 
     880473735 
    chicken
    (Gallus gallus)
    Aves SRSF11 serine/arginine-rich splicing factor 1 87.9(n)
    98.79(a)
      772264  NM_001113741.1  NP_001107213.1 
    lizard
    (Anolis carolinensis)
    Reptilia SRSF16
    Uncharacterized protein
    98(a)
    1 ↔ 1
    GL344193.1(34598-38309)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042354.12   -- 88.33(n)    BC042354.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056752.12   -- 79.13(n)   393565  BC056752.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta SF21 CG6987-PA 62.36(n)
    68.53(a)
      53443  NM_144354.2  NP_652611.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rsp-31 Protein RSP-3 61.9(n)
    66.52(a)
      176688  NM_067248.3  NP_499649.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G024301 splicing factor SR1B 60.43(n)
    65.75(a)
      828027  NM_116476.3  NP_567235.3 
    rice
    (Oryza sativa)
    Liliopsida Os07g06735001 hypothetical protein 55.9(n)
    61.5(a)
      4344256  NM_001067143.1  NP_001060608.1 


    ENSEMBL Gene Tree for SRSF1 (if available)
    TreeFam Gene Tree for SRSF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF1 gene
    SRSF52  SRSF92  SRSF72  SRSF62  SRSF42  SRSF32  
    11 SIMAP similar genes for SRSF1 using alignment to 5 protein entries:     SRSF1_HUMAN (see all proteins):
    SRSF9    SRSF5    SPEN    SFRS5    RBMX    SRSF6
    SFRS4    CIRBP    SRSF4    SFRS3    RNPS1

    SRSF1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SRSF1
    PGOHUM00000262883 PGOHUM00000262884


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/160 SNPs in SRSF1 are shown (see all 160)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0354884
    A breast cancer sample4--see VAR_0354882 P S mis40--------
    rs1859090811,2
    --56077883(+) TATTTG/TCTTCA 3 -- ds50010--------
    rs1414561581,2
    --56078142(+) TCAGAA/GCTGTA 3 -- ds50010--------
    rs1452077771,2
    C--56078423(+) GTTATA/GTTACA 3 -- ut31 nc-transcript-variant0--------
    rs2017517321,2
    C--56078528(+) TATAC-/AAGT  
            
    AGTAA
    3 -- ut31 nc-transcript-variant0--------
    rs1476229191,2
    C--56078531(+) CAAAGC/TAAGCA 3 -- ut31 nc-transcript-variant0--------
    rs1892154851,2
    --56078578(+) AATGTA/GAAAAC 3 -- ut31 nc-transcript-variant0--------
    rs88191,2
    C,F,O,A,H--56078738(-) TCCCCG/ATAAAA 3 -- ut31 nc-transcript-variant15Minor allele frequency- A:0.33MN NS EA NA WA CSA 1159
    rs1823658171,2
    --56078788(+) ACTTAA/GCTTAG 3 -- ut31 nc-transcript-variant0--------
    rs345924921,2
    C,F--56079037(+) TTGTAG/CTTTCA 3 -- ut31 nc-transcript-variant10Minor allele frequency- C:0.07NA EA CSA WA 608

    HapMap Linkage Disequilibrium report for SRSF1 (56078280 - 56084707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SRSF1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833497CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SRSF1
    DNA2.0 Custom Variant and Variant Library Synthesis for SRSF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600812    OMIM disorders: --

    14 diseases for SRSF1:    About MalaCards
    cble    afibrinogenemia    homocystinuria    growth hormone deficiency
    spinal muscular atrophy    muscular atrophy    vaccinia    macular degeneration
    ataxia    sarcoma    hypoxia    lung cancer
    endotheliitis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for SRSF1:
    Cancer     Acquired immunodeficiency syndrome

    SRSF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRSF1

    Export disorders for SRSF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF1 gene, integrated from 9 sources (see all 210):
    (articles sorted by number of sources associating them with SRSF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). (PubMed id 8530103)1, 3, 9 Bermingham J.R....Rosenfeld M.G. (1995)
    2. Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. (PubMed id 1855257)1, 2, 9 Ge H.... Manley J.L. (1991)
    3. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    4. Regiospecific phosphorylation control of the SR prote in ASF/SF2 by SRPK1. (PubMed id 19477182)1, 2 Ma C.T....Adams J.A. (2009)
    5. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D....Hughes T.R. (2009)
    6. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. (PubMed id 18687337)1, 2 Hagopian J.C....Adams J.A. (2008)
    7. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. (PubMed id 18155240)1, 2 Ma C.T....Adams J.A. (2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. A novel SR-related protein is required for the second step of Pre-mRNA splicing. (PubMed id 15798186)1, 2 Cazalla D....Caceres J.F. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6426 HGNC: 10780 AceView: SFRS1 Ensembl:ENSG00000136450 euGenes: HUgn6426
    ECgene: SRSF1 Kegg: 6426 H-InvDB: SRSF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SRSF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRSF1 gene:
    Search GeneIP for patents involving SRSF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SRSF1
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SRSF1   OriGene RNAi products in human, mouse, rat for SRSF1  
     OriGene qPCR primer pairs and template standards for SRSF1   OriGene Protein Over-expression Lysate for SRSF1  
     OriGene MassSpec something-or-other for SRSF1   OriGene clones in human, mouse for SRSF1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRSF1   OriGene Purified Protein for SRSF1  
     OriGene ORF clones in mouse, rat for SRSF1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRSF1   OriGene Custom Protein Services for SRSF1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRSF1
     QIAGEN SeqTarget long-range PCR primers for resequencing SRSF1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRSF1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRSF1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRSF1
     GenScript Custom Purified and Recombinant Proteins Services for SRSF1 GenScript cDNA clones with any tag delivered in your preferred vector for SRSF1
     GenScript Custom Assay Services for SRSF1 GenScript Custom Superior Antibodies Services for SRSF1
     GenScript Custom overexpressing Cell Line Services for SRSF1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for SRSF1  (SF2)

     Search Regulatory tfbs for SRSF1
     Search Chromatin IP Primers for SRSF1
     RT2 qPCR Primer Assay in human, mouse, rat SRSF1
     Search GNC Networks for SRSF1
     SABiosciences Custom PCR Arrays for SRSF1
     Search Tocris compounds for SRSF1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SRSF1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SRSF1 antibodies
     SRSF1 proteins
     SRSF1 lysates
     Antibodies for SRSF1
     See all of Abcam's Antibodies, Kits and Proteins for SRSF1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for SRSF1




     Proteins for SRSF1
     Antibodies for SRSF1
     ELISAs for SRSF1
     CLIAs for SRSF1
     Search LifeMap BioReagents cell lines for SRSF1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRSF1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SRSF1
     SwitchGear Promoter luciferase reporter plasmids for SRSF1
     ThermoFisher Antibody for SRSF1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRSF1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SRSF1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRSF1
    Customized:
     lentivirus for stable overexpression of SRSF1
     lentivirus expression plasmids for stable overexpression of SRSF1
     adenovirus for overexpression of SRSF1
     LSBio Antibodies in human, mouse, rat for SRSF1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRSF1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4