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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRSF1 Gene

protein-coding   GIFtS: 59
GCID: GC17M056079

serine/arginine-rich splicing factor 1

(Previous names: splicing factor, arginine/serine-rich 1 )
(Previous symbol: SFRS1)
 Explore 18 diseases affiliated with
SRSF1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SRSF1    

Aliases
for SRSF1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Serine/Arginine-Rich Splicing Factor 11 2     Alternative-Splicing Factor 12 3
SFRS11 2 3 5     ASF-12 3
Splicing Factor, Arginine/Serine-Rich 11 2 3     Pre-MRNA-Splicing Factor SF2, P33 Subunit2 3
ASF1 2 3     MGC52281
SF21 2 3     Splicing Factor 22
SF2p331 2     SR Splicing Factor 12
SRp30a1 2     SF2P333

External Ids:    HGNC: 107801   Entrez Gene: 64262   Ensembl: ENSG000001364507   OMIM: 6008125   UniProtKB: Q079553   
ORGUL members:         
NONCODE:n409655    

Export aliases for SRSF1 gene to outside databases

Previous GC identifer: GC17M051439


Summaries
for SRSF1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SRSF1:
This gene encodes a member of the arginine/serine-rich splicing factor protein family, and functions in both
constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the
spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The
protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor
associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene. In
addition, a pseudogene of this gene has been found on chromosome 13. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: SRSF1_HUMAN, Q07955
Function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative
splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and
3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing
pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers,
AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer
constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate
ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors

Gene Wiki entry for SRSF1 (ASF/SF2)


Genomic Views
for SRSF1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRSF1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRSF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRSF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRSF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

SRSF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRSF1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056079:  view genomic region     (about GC identifiers)

Start:
 56,078,280 bp from pter      End:
 56,084,707 bp from pter
Size:
 6,428 bases      Orientation:
 minus strand

Proteins
for SRSF1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRSF1_HUMAN, Q07955 (See protein sequence)
Recommended Name: Serine/arginine-rich splicing factor 1  
Size: 248 amino acids; 27745 Da
Subunit: Consists of two polypeptides of p32 and p33. In vitro, self-associates and binds SRSF2, SNRNP70 and U2AF1 but
not U2AF2. Binds SREK1/SFRS12. Interacts with SAFB/SAFB1. Interacts with PSIP1/LEDGF. Interacts with SRPK1. Identified
in the spliceosome C complex. Interacts with RSRC1 (via Arg/Ser-rich domain). Interacts with ZRSR2/U2AF1-RS2.
Interacts with CCDC55 (via C-terminus). Interacts with SRPK1 and a sliding docking interaction is essential for its
sequential and processive phosphorylation by SRPK1
Subcellular location: Cytoplasm. Nucleus speckle. Note=In nuclear speckles. Shuttles between the nucleus and the
cytoplasm
3 PDB 3D structures from and Proteopedia for SRSF1:
1X4A (3D)        2O3D (3D)        3BEG (3D)    
Secondary accessions: B2R6Z7 D3DTZ3 Q13809
Alternative splicing: 3 isoforms:  Q07955-1   Q07955-2   Q07955-3   (May be due to intron retention)

Explore the universe of human proteins at neXtProt for SRSF1: NX_Q07955

Post-translational modifications:

  • Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Phosphorylated by SRPK1 at multiple serines in its RS domain via a
    • directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in
    which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation
    steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds to
    a docking groove in the large lobe of the kinase domain of SRPK1 and this induces certain structural changes in SRPK1
    and/or RRM 2 domain of SRSF1, allowing RRM 2 to bind the kinase and initiate phosphorylation. The cycles continue for
    several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps
    (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM 2,
    which then docks at the docking groove of SRPK1. This also signals RRM 2 to begin to dissociate, which facilitates
    SRSF1 dissociation after phosphorylation is completed1
  • Arg-97 is dimethylated, probably to asymmetric dimethylarginine1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q07955

    • SRSF1 Protein expression data from MOPED and PaxDb:    About this image 
    SRSF1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001071634.1  NP_008855.1  

    ENSEMBL proteins: 
     ENSP00000462215   ENSP00000462616   ENSP00000463223   ENSP00000463042   ENSP00000462687  
     ENSP00000463917   ENSP00000258962  
    Reactome Protein details: Q07955
    Human Recombinant Protein Products for SRSF1: 
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    Novus Biologicals SRSF1 Protein
    Novus Biologicals SRSF1 Lysates
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    Uscn Proteins for SRSF1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016607nuclear speck IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    SRSF1 for ontologies           About GeneDecksing



    SRSF1 Antibody Products: 
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    Uscn ELISAs and CLIAs for SRSF1

    Protein Domains /
    Families
    for SRSF1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRSF1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q07955

    ProtoNet protein and cluster: Q07955

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: SRSF1_HUMAN, Q07955
    Domain: The RRM 2 domain plays an important role in governing both the binding mode and the phosphorylation mechanism
    of the RS domain by SRPK1. RS domain and RRM 2 are uniquely positioned to initiate a highly directional (C-terminus to
    N-terminus) phosphorylation reaction in which the RS domain slides through an extended electronegative channel
    separating the docking groove of SRPK1 and the active site. RRM 2 binds toward the periphery of the active site and
    guides the directional phosphorylation mechanism. Both the RS domain and an RRM domain are required for
    nucleocytoplasmic shuttling
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for SRSF1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRSF1_HUMAN, Q07955
    Function: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative
    splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and
    3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing
    pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers,
    AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer
    constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate
    ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IPI--
    GO:0005515protein binding IPI--
    GO:0050733RS domain binding IEA--
         
    SRSF1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SRSF1:
     Decreased viability  Increased gamma-H2AX phosphory  Synthetic lethal with Ras  Synthetic lethal with imatinib 
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Srsf1):
     cardiovascular system  cellular  mortality/aging  muscle  nervous system 
     vision/eye 

    SRSF1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Srsf1tm1.1Xdfu for SRSF1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SRSF1 

    miRNA
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    hsa-mir-7 (MIRT004497)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRSF1
    8/174 QIAGEN miScript miRNA Assays for microRNAs that regulate SRSF1 (see all 174):
    hsa-miR-124* hsa-miR-579 hsa-miR-576-3p hsa-miR-100* hsa-miR-640 hsa-miR-3938 hsa-miR-376b hsa-miR-517a
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for SRSF1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		mRNA Splicing - Major Pathway1.00
    		mRNA processing0.48
    		mRNA Splicing1.00
    		mRNA Splicing - Minor Pathway0.40
    		Processing of Capped Intron-Containing Pre-mRNA0.96
    		Spliceosome0.31
    		mRNA Processing0.82
    2RNA Polymerase II Transcription Termination
    		RNA Polymerase II Transcription Termination1.00
    		Post-Elongation Processing of Intron-Containing pre-mRNA0.79
    		Post-Elongation Processing of the Transcript1.00
    		mRNA 3'-end processing0.79
    		Cleavage of Growing Transcript in the Termination Region 1.00
    3Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69
    4Transport of Mature Transcript to Cytoplasm
    		Transport of Mature Transcript to Cytoplasm1.00
    		Transport of Mature mRNA derived from an Intron-Containing Transcript0.85
    5Translational Control
    		Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SRSF1
        Translational Control

    1 BioSystems Pathway for SRSF1 
        mRNA processing

    5/15        Reactome Pathways for SRSF1 (see all 15)
        Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA Splicing - Major Pathway
    Transport of Mature Transcript to Cytoplasm
    mRNA Splicing
    RNA Polymerase II Transcription


    1         Kegg Pathway  (Kegg details for SRSF1):
        Spliceosome


    SRSF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRSF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/865 Interacting proteins for SRSF1 (Q079551, 2, 3 ENSP000002589624) via UniProtKB, MINT, STRING, and/or I2D (see all 865)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DIDO1Q9BTC02, 3, ENSP000002660704MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000266070
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000221448
    SF3A2Q154282, 3, ENSP000002214944MINT-5205701 MINT-7947479 I2D: score=2 STRING: ENSP00000221494
    NPM1P067482, 3, ENSP000002969304MINT-75017 MINT-7947479 I2D: score=1 STRING: ENSP00000296930
    RBM39Q144982, 3, ENSP000002533634MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000253363
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000395mRNA 5'-splice site recognition IDA9885563
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0001701in utero embryonic development IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--

    SRSF1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRSF1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SRSF1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SRSF1
    2 Novoseek chemical compound relationships for SRSF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 43.4 3 10092085 (1), 18853456 (1)
    serine 31.1 1 9611241 (1)

    Search CenterWatch for drugs/clinical trials and news about SRSF1 

    Transcripts
    for SRSF1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SRSF1 gene (2 alternative transcripts): 
    NM_001078166.1  NM_006924.4  

    Unigene Cluster for SRSF1:

    Serine/arginine-rich splicing factor 1
    Hs.68714  [show with all ESTs]
    Unigene Representative Sequence: NM_001078166
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000581497 ENST00000582730(uc002ivi.3 uc002ivj.3) ENST00000584668
    ENST00000581979 ENST00000584773 ENST00000585096 ENST00000583741 ENST00000258962
    ENST00000578430

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    hsa-miR-124* hsa-miR-579 hsa-miR-576-3p hsa-miR-100* hsa-miR-640 hsa-miR-3938 hsa-miR-376b hsa-miR-517a
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB062124.1 AB209558.1 AK225711.1 AK289933.1 AK298527.1 AK307360.1 AK312781.1 BC010264.1 
    M69040.1 M72709.1 NR_034041.1 

    24/27 DOTS entries (see all 27):

    DT.95317930  DT.100702121  DT.100878381  DT.100683062  DT.95317987  DT.92461044  DT.91996892  DT.120953879 
    DT.308110  DT.100878386  DT.100724456  DT.86841028  DT.120953872  DT.120953824  DT.120953813  DT.120953835 
    DT.120953866  DT.95317845  DT.120953805  DT.40311635  DT.92461026  DT.95317978  DT.120953822  DT.120953864 

    24/814 AceView cDNA sequences (see all 814):

    AI370961 W15251 AA745651 AK054610 AU121159 BQ084365 BM474821 AA460419 
    BE328371 BM550276 AA327734 AI479968 BQ897646 M69040 BQ926120 BM977587 
    BG503223 AA455164 AB062124 BI258776 BM474872 AA334277 BQ005780 BM451895 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SRSF1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                                              -                             -               
    SP2:                                -                             -                                             
    SP3:                                -                             -                             -               
    SP4:                                                              -                                             
    SP5:                                -                             -                                             


    ECgene alternative splicing isoforms for SRSF1

    Expression
    for SRSF1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRSF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCGGGATC
    SRSF1 Expression
    About this image
    See SRSF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRSF1

    SOURCE GeneReport for Unigene cluster: Hs.68714
        SABiosciences Custom PCR Arrays for SRSF1

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    In Situ
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    Orthologs
    for SRSF1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRSF1 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SRSF11 serine/arginine-rich splicing factor 1 87.9(n)
    98.79(a)    		   772264  NM_001113741.1  NP_001107213.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SRSF16
    		 --
    		 99(a)
    		 1 ↔ 1
    		 GL344193.1(34598-38309)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC042354.12   -- 88.33(n)    BC042354.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC056752.12   -- 79.13(n)   393565  BC056752.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta SF21 CG6987-PA 62.36(n)
    68.53(a)    		   53443  NM_144354.2  NP_652611.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea rsp-31 Protein RSP-3 61.9(n)
    66.52(a)    		   176688  NM_067248.3  NP_499649.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G024301 splicing factor SR1B 60.43(n)
    65.75(a)    		   828027  NM_116476.3  NP_567235.3 
    rice
    (Oryza sativa)    		 Liliopsida Os07g06735001 hypothetical protein 55.9(n)
    61.5(a)    		   4344256  NM_001067143.1  NP_001060608.1 


    ENSEMBL Gene Tree for SRSF1 (if available)
    TreeFam Gene Tree for SRSF1 (if available) 

    Paralogs
    for SRSF1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRSF1 gene
    LOC1009966572  SRSF42  SRSF122  SRSF102  SRSF92  SRSF52  SRSF22  SRSF72  
    SRSF62  SRSF32  
    10 SIMAP similar genes for SRSF1 using alignment to 5 protein entries:     SRSF1_HUMAN (see all proteins):
    SRSF9    SRSF5    SPEN    SFRS5    RBMX    SRSF6
    SFRS4    CIRBP    SRSF4    SFRS3

    SRSF1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SRSF1
    PGOHUM00000262883 PGOHUM00000262884


    Genomic Variants
    for SRSF1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/119 NCBI SNPs in SRSF1 are shown (see all 119)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1859090811,2
    		--56077883(+) TATTTG/TCTTCA 3 -- ds50010--------
    rs1414561581,2
    		--56078142(+) TCAGAA/GCTGTA 3 -- ds50010--------
    rs1452077771,2
    		--56078423(+) GTTATA/GTTACA 3 -- ut31 nc-transcript-variant0--------
    rs2017517321,2
    		--56078528(+) ATACA-/AAGT  
                AAGCA     		3 -- ut31 nc-transcript-variant0--------
    rs1476229191,2
    		--56078531(+) CAAAGC/TAAGCA 3 -- nc-transcript-variantut310--------
    rs1892154851,2
    		--56078578(+) AATGTA/GAAAAC 3 -- ut31 nc-transcript-variant0--------
    rs88191,2
    		C,F,O,A,H--56078738(-) TCCCCG/ATAAAA 3 -- ut31 nc-transcript-variant15Minor allele frequency- A:0.33MN NS EA NA WA CSA 1159
    rs1823658171,2
    		--56078788(+) ACTTAA/GCTTAG 3 -- ut31 nc-transcript-variant0--------
    rs345924921,2
    		C,F--56079037(+) TTGTAG/CTTTCA 3 -- ut31 nc-transcript-variant10Minor allele frequency- C:0.07NA EA CSA WA 608
    rs1168773751,2
    		C,F--56079077(+) NNNNAC/TGGATA 3 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for SRSF1 (56078280 - 56084707 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SRSF1: --

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    Disorders / Diseases
    for SRSF1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRSF1 for disorders           About GeneDecksing

    OMIM gene information: 600812    OMIM disorders: --

    18 diseases for SRSF1:    About MalaCards
    spinal muscular atrophy    dna topoisomerase i    growth hormone deficiency    cble
    x inactivation    metastasis efficiency    afibrinogenemia    macular degeneration
    muscular atrophy    homocystinuria    vaccinia    lung cancer
    ataxia    sarcoma    hypoxia    immunodeficiency
    hepatitis    malaria

    1 disease from the University of Copenhagen DISEASES database for SRSF1:
    Cancer

    Export disorders for SRSF1 gene to outside databases

    Publications
    for SRSF1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRSF1 gene, integrated from 9 sources (see all 191):
    (articles sorted by number of sources associating them with SRSF1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). (PubMed id 8530103)1, 3, 9 Bermingham J.R....Rosenfeld M.G. (1995)
    2. Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. (PubMed id 1855257)1, 2, 9 Ge H.... Manley J.L. (1991)
    3. A rational nomenclature for serine/arginine-rich prot ein splicing factors (SR proteins). (PubMed id 20516191)1, 3 Manley J.L. and Krainer A.R. (2010)
    4. Regiospecific phosphorylation control of the SR prote in ASF/SF2 by SRPK1. (PubMed id 19477182)1, 2 Ma C.T....Adams J.A. (2009)
    5. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. (PubMed id 19561594)1, 2 Ray D....Hughes T.R. (2009)
    6. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. (PubMed id 18687337)1, 2 Hagopian J.C....Adams J.A. (2008)
    7. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. (PubMed id 18155240)1, 2 Ma C.T....Adams J.A. (2008)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Processive phosphorylation of alternative splicing factor/splicing factor 2. (PubMed id 14555757)1, 2 Aubol B.E.... Adams J.A. (2003)

    External Searches for SRSF1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SRSF1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6426 HGNC: 10780 AceView: SFRS1 Ensembl:ENSG00000136450 euGenes: HUgn6426
    ECgene: SRSF1 Kegg: 6426 H-InvDB: SRSF1

    Other Databases showing SRSF1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SRSF1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRSF1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRSF1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SRSF1 gene:
    Search GeneIP for patents involving SRSF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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