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SRRT Gene

protein-coding   GIFtS: 54
GCID: GC07P100472

Serrate RNA Effector Molecule Homolog (Arabidopsis)

  Search for SRRT
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serrate RNA Effector Molecule Homolog (Arabidopsis)1 2     Arsenate Resistance Protein 22
ARS22 3 5     Arsenate Resistance Protein ARS22
Arsenite Resistance Protein1 2     serrate2
Arsenite-Resistance Protein 22 3     Serrate RNA Effector Molecule Homolog2
ASR22 3     

External Ids:    HGNC: 241011   Entrez Gene: 515932   Ensembl: ENSG000000870877   OMIM: 6144695   UniProtKB: Q9BXP53   

Export aliases for SRRT gene to outside databases

Previous GC identifers: GC07P100311 GC07P095103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRRT Gene:
SRRT (serrate RNA effector molecule homolog (Arabidopsis)) is a protein-coding gene.

UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
Function: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing
machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA
transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in
RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is
probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle
progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does
so by directly binding SOX2 promoter and positively regulating its transcription (By similarity)

Gene Wiki entry for SRRT (ARS2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRRT gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRRT promoter sequence
   Search Chromatin IP Primers for SRRT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21

SRRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100472:  view genomic region     (about GC identifiers)

Start:
100,472,701 bp from pter      End:
100,486,285 bp from pter
Size:
13,585 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,832,306-99,845,890     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5 (See protein sequence)
Recommended Name: Serrate RNA effector molecule homolog  
Size: 876 amino acids; 100666 Da
Subunit: Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4
Sequence caution: Sequence=AAD17774.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAM00189.1; Type=Frameshift; Positions=102; Sequence=BAG58876.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAL23816.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D2E5 A4D2E6 A6NK22 B4DJL4 B4DZA6 O95808 Q32MI4 Q6NT74 Q8TDQ5 Q9BWP6
Q9BXP4 Q9Y4S4
Alternative splicing: 5 isoforms:  Q9BXP5-1   Q9BXP5-2   Q9BXP5-3   Q9BXP5-4   Q9BXP5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRRT: NX_Q9BXP5

Explore proteomics data for SRRT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys153, Lys476, Lys526, Lys758
  • Modification sites at PhosphoSitePlus

  • See SRRT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001122324.1  NP_001122325.1  NP_001122326.1  NP_056992.4  

    ENSEMBL proteins: 
     ENSP00000416553   ENSP00000373445   ENSP00000402025   ENSP00000391852   ENSP00000314491  
     ENSP00000400912   ENSP00000396807   ENSP00000410588   ENSP00000400703   ENSP00000398618  

    SRRT Human Recombinant Protein Products:

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    Novus Biologicals SRRT Protein
    Novus Biologicals SRRT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRRT

     
    Search eBioscience for Proteins for SRRT 

    SRRT Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRRT
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    Novus Biologicals SRRT Antibodies
    Abcam antibodies for SRRT
    Cloud-Clone Corp. Antibodies for SRRT
    ThermoFisher Antibody for SRRT
    LSBio Antibodies in human, mouse, rat for SRRT

    SRRT Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRRT
    Cloud-Clone Corp. CLIAs for SRRT
    Search eBioscience for ELISAs for SRRT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007042 Arsenite-R_2
     IPR021933 DUF3546

    Graphical View of Domain Structure for InterPro Entry Q9BXP5

    ProtoNet protein and cluster: Q9BXP5

    1 Blocks protein domain: IPB007042 Arsenite-resistance protein 2

    UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
    Similarity: Belongs to the ARS2 family


    Find genes that share domains with SRRT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRRT_HUMAN, Q9BXP5
    Function: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing
    machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA
    transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in
    RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is
    probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle
    progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
    Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does
    so by directly binding SOX2 promoter and positively regulating its transcription (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI17500595
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRRT           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SRRT:
     Decreased POU5F1-GFP protein e  Decreased viability  G0/1 arrest  Increased G1 DNA content 
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Srrt):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with SRRT           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SRRT: Srrttm1Bfk Srrttm1.2Thsn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRRT
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SRRT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRRT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRRT

    miRNA
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    miRTarBase miRNAs that target SRRT:
    hsa-mir-196a-5p (MIRT026028), hsa-mir-30c-1-3p (MIRT038543), hsa-mir-24-3p (MIRT030477), hsa-mir-92a-3p (MIRT049730), hsa-mir-222-3p (MIRT046768), hsa-mir-1914-5p (MIRT035793)

    Block miRNA regulation of human, mouse, rat SRRT using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat SRRT

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    OriGene ORF clones in mouse, rat for SRRT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SRRT (NM_001128854)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRT

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRRT_HUMAN, Q9BXP5: Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear.
    Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm ISS--
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with SRRT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRRT
    Interactions:

        Search GeneGlobe Interaction Network for SRRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for SRRT (Q9BXP52, 3 ENSP000003144914) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5206034 I2D: score=1 STRING: ENSP00000221494
    GIT1Q9Y2X72, 3MINT-65856 I2D: score=5 
    IMMTQ168912, 3MINT-65854 I2D: score=5 
    VIMP086702, 3MINT-65855 I2D: score=5 
    CHD3Q128732, 3, ENSP000003697164MINT-65857 I2D: score=5 STRING: ENSP00000369716
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ISS--
    GO:0008283cell proliferation ISS--
    GO:0031053primary miRNA processing IMP19632182
    GO:0046685response to arsenic-containing substance NAS11239002

    Find genes that share ontologies with SRRT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRRT



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRRT gene (5 alternative transcripts): 
    NM_182800.2  NM_001128852.1  NM_001128853.1  NM_001128854.1  NM_015908.5  

    Unigene Cluster for SRRT:

    Serrate RNA effector molecule homolog (Arabidopsis)
    Hs.111801  [show with all ESTs]
    Unigene Representative Sequence: NM_015908
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473047 ENST00000457580(uc003uxa.2 uc003uwz.2) ENST00000388793(uc010lhl.1 uc003uwy.2)
    ENST00000448716 ENST00000432932 ENST00000347433 ENST00000431645 ENST00000423692
    ENST00000474896 ENST00000460194 ENST00000448764 ENST00000449389 ENST00000466432
    ENST00000487311 ENST00000469602 ENST00000478693 ENST00000445337 ENST00000477529

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRRT
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    GenScript: all cDNA clones in your preferred vector (see all 4): SRRT (NM_001128854)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRT
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRRT
      QuantiTect SYBR Green Assays in human, mouse, rat SRRT
      QuantiFast Probe-based Assays in human, mouse, rat SRRT

    Additional mRNA sequence: 

    AF082871.1 AF112994.1 AF248955.1 AK296131.1 AK302820.1 AK311728.1 AL096723.1 BC000082.2 
    BC069249.1 BC109116.1 BC109117.1 

    24 DOTS entries:

    DT.87017455  DT.102834112  DT.100816896  DT.120398  DT.92445924  DT.100816898  DT.215325  DT.95313627 
    DT.121050654  DT.95323020  DT.95323029  DT.95361719  DT.97777794  DT.121050640  DT.121050659  DT.121050666 
    DT.449009  DT.91954045  DT.92445902  DT.95104632  DT.95323021  DT.95323023  DT.97864514  DT.92020880 

    Selected AceView cDNA sequences (see all 428):

    CK903948 CB158279 BM552596 T78538 BF515651 BM053021 BQ003547 BE675611 
    AI130771 AW450315 CF529899 AI475785 AI312084 BF515633 BM553083 AW194851 
    AW301115 BE207971 BM840646 AF082871 BM796894 AI654926 BQ008891 AA262726 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRRT (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:  -                 -           -           -                       -                                                         
    SP2:                    -           -           -                       -                             -                           
    SP3:  -                 -           -                                                                                             
    SP4:  -                 -           -                                                                                             
    SP5:  -                 -           -           -                                                                                 


    ECgene alternative splicing isoforms for SRRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGTATGG
    SRRT Expression
    About this image


    SRRT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Ovary (Reproductive System)
     
     Testis (Reproductive System)
     
     Uterus (Reproductive System)
     
     Spleen (Hematopoietic System)
    SRRT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRRT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111801

    UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SRRT gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srrt1 , 5 serrate RNA effector molecule homolog (Arabidopsis)1, 5 87.99(n)1
    97.04(a)1
      5 (76.33 cM)5
    837011  NM_001109909.11  NP_001103379.11 
     1372957045 
    lizard
    (Anolis carolinensis)
    Reptilia SRRT6
    serrate RNA effector molecule homolog (Arabidopsis...
    81(a)
    1 ↔ 1
    GL343939.1(21-31399)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985422 similar to arsenate resistance protein 2 75.54(n)    BC041542.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ars22 arsenate resistance protein 2 77.82(n)   192311  AF506224.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ars21 Ars2 55.72(n)
    52.59(a)
      35539  NM_165458.2  NP_724453.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E01A2.21 E01A2.2 52.63(n)
    49.54(a)
      171996  NM_058901.4  NP_491302.1 


    ENSEMBL Gene Tree for SRRT (if available)
    TreeFam Gene Tree for SRRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRRT (see all 566)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3752837301,2
    C--103776751(+) GCCTCA/GCTTCT 4 -- us2k10--------
    rs2010907381,2
    --103776788(+) GCCATC/TGCGCC 4 -- us2k10--------
    rs617489471,2
    C,F--103776852(+) AGGGCG/AAGTGT 4 -- us2k12Minor allele frequency- A:0.00NS NA 4620
    rs1446615521,2
    C--103776905(+) TGCAGC/TGCCTG 4 -- us2k11Minor allele frequency- T:0.00NA 4552
    rs1386134371,2
    F--103776932(+) TCAGCC/TACCGT 4 -- us2k11Minor allele frequency- T:0.00NA 4552
    rs1434291071,2
    --103776961(+) CTTCCC/TAGAAG 4 -- us2k10--------
    rs1143244021,2
    C,F--103776984(+) TCTCAG/ATTCCA 4 -- us2k11Minor allele frequency- A:0.04WA 118
    rs733966401,2
    C,F--103777022(+) CCTGAC/TATCCA 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs67061,2
    C,F,A,H--103777072(+) CCAATC/TAAGAA 4 -- us2k118Minor allele frequency- T:0.15MN NS EA NA 2474
    rs125382871,2
    C,F,H--103777149(+) CATTAC/AAGGCC 4 -- us2k119Minor allele frequency- A:0.24NS EA NA CSA WA 2344

    HapMap Linkage Disequilibrium report for SRRT (100472701 - 100486285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SRRT:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv5870CNV Insertion18451855
    dgv7403n71CNV Loss21882294
    dgv7404n71CNV Loss21882294
    nsv831073CNV Loss17160897
    dgv7402n71CNV Loss21882294
    dgv2119e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRRT
    DNA2.0 Custom Variant and Variant Library Synthesis for SRRT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614469    OMIM disorders: --


    Find genes that share disorders with SRRT           About GenesLikeMe

    Genetic Association Database (GAD): SRRT

    Export disorders for SRRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRRT gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with SRRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2, 3 Wilson M.D.... Koop B.F. (Nucleic Acids Res. 2001)
    3. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PubMed id 19546234)1, 2, 9 Kiriyama M.... Yonehara S. (Mol. Cell. Biol. 2009)
    4. Genome-wide association analysis identifies multiple loci related to resting heart rate. (PubMed id 20639392)1, 4 Eijgelsheim M....O'Donnell C.J. (Hum. Mol. Genet. 2010)
    5. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. (PubMed id 19632182)1, 2 Gruber J.J.... Thompson C.B. (Cell 2009)
    6. ARS2 is a conserved eukaryotic gene essential for early mammalian development. (PubMed id 18086880)1, 2 Wilson M.D.... Howard P.L. (Mol. Cell. Biol. 2008)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51593 HGNC: 24101 AceView: ARS2 Ensembl:ENSG00000087087 euGenes: HUgn51593
    ECgene: SRRT H-InvDB: SRRT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRRT gene:
    Search GeneIP for patents involving SRRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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