Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRRT Gene

protein-coding   GIFtS: 53
GCID: GC07P100472

Serrate RNA Effector Molecule Homolog (Arabidopsis)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serrate RNA Effector Molecule Homolog (Arabidopsis)1 2     Arsenate Resistance Protein 22
Arsenite Resistance Protein1 2     Arsenate Resistance Protein ARS22
Arsenite-Resistance Protein 22 3     serrate2
ARS22 3     Serrate RNA Effector Molecule Homolog2
ASR22 3     

External Ids:    HGNC: 241011   Entrez Gene: 515932   Ensembl: ENSG000000870877   OMIM: 6144695   UniProtKB: Q9BXP53   

Export aliases for SRRT gene to outside databases

Previous GC identifers: GC07P100311 GC07P095103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SRRT Gene: 
SRRT (serrate RNA effector molecule homolog (Arabidopsis)) is a protein-coding gene. Diseases associated with SRRT include spondylocostal dysostosis, and resting heart rate. GO annotations related to this gene include protein binding and DNA binding.

UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
Function: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing
machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA
transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in
RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is
probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle
progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does
so by directly binding SOX2 promoter and positively regulating its transcription (By similarity)

Gene Wiki entry for SRRT (ARS2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRRT gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRRT promoter sequence
   Search SABiosciences Chromatin IP Primers for SRRT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21

SRRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100472:  view genomic region     (about GC identifiers)

Start:
100,472,701 bp from pter      End:
100,486,285 bp from pter
Size:
13,585 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,832,306-99,845,890     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5 (See protein sequence)
Recommended Name: Serrate RNA effector molecule homolog  
Size: 876 amino acids; 100666 Da
Subunit: Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4
Subcellular location: Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear.
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity)
Sequence caution: Sequence=AAD17774.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAM00189.1; Type=Frameshift; Positions=102; Sequence=BAG58876.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=EAL23816.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D2E5 A4D2E6 A6NK22 B4DJL4 B4DZA6 O95808 Q32MI4 Q6NT74 Q8TDQ5 Q9BWP6
Q9BXP4 Q9Y4S4
Alternative splicing: 5 isoforms:  Q9BXP5-1   Q9BXP5-2   Q9BXP5-3   Q9BXP5-4   Q9BXP5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRRT: NX_Q9BXP5

Explore proteomics data for SRRT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXP5

  • SRRT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRRT Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001122324.1  NP_001122325.1  NP_001122326.1  NP_056992.4  

    ENSEMBL proteins: 
     ENSP00000416553   ENSP00000373445   ENSP00000402025   ENSP00000391852   ENSP00000314491  
     ENSP00000400912   ENSP00000396807   ENSP00000410588   ENSP00000400703   ENSP00000398618  

    Human Recombinant Protein Products for SRRT: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SRRT
    OriGene Protein Over-expression Lysate for SRRT
    OriGene MassSpec for SRRT 
    OriGene Custom Protein Services for SRRT
    GenScript Custom Purified and Recombinant Proteins Services for SRRT
    Novus Biologicals SRRT Protein
    Novus Biologicals SRRT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRRT 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm ISS--
    GO:0005737cytoplasm ISS--

    SRRT for ontologies           About GeneDecksing



    SRRT Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SRRT
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SRRT
    GenScript Custom Superior Antibodies Services for SRRT
    Novus Biologicals SRRT Antibodies
    Abcam antibodies for SRRT
    Cloud-Clone Corp. Antibodies for SRRT 
    ThermoFisher Antibody for SRRT
    LSBio Antibodies in human, mouse, rat for SRRT 

    Assay Products for SRRT: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SRRT
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SRRT
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SRRT 
    Cloud-Clone Corp. CLIAs for SRRT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007042 Arsenite-R_2
     IPR021933 DUF3546

    Graphical View of Domain Structure for InterPro Entry Q9BXP5

    ProtoNet protein and cluster: Q9BXP5

    1 Blocks protein domain: IPB007042 Arsenite-resistance protein 2

    UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
    Similarity: Belongs to the ARS2 family


    SRRT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRRT_HUMAN, Q9BXP5
    Function: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing
    machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA
    transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in
    RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is
    probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle
    progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
    Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does
    so by directly binding SOX2 promoter and positively regulating its transcription (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI--
         
    SRRT for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SRRT:
     Decreased POU5F1-GFP protein e  Decreased viability  G0/1 arrest  Increased G1 DNA content 
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Srrt):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    SRRT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SRRT: Srrttm1Bfk Srrttm1.2Thsn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRRT 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRRT

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRRT 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRRT 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRRT
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SRRT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRRT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRT

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SRRT
    Sirion Biotech Customized adenovirus for overexpression of SRRT

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SRRT (see all 22)
    OriGene ORF clones in mouse, rat for SRRT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SRRT (NM_001128854)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRT
    Sirion Biotech Customized lentivirus for stable overexpression of SRRT 
                         Customized lentivirus expression plasmids for stable overexpression of SRRT 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SRRT
    Search LifeMap BioReagents cell lines for SRRT
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRT


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/34 Interacting proteins for SRRT (Q9BXP52, 3 ENSP000003144914) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5206034 I2D: score=1 STRING: ENSP00000221494
    CHD3Q128732, 3MINT-65857 I2D: score=5 
    GIT1Q9Y2X72, 3MINT-65856 I2D: score=5 
    IMMTQ168912, 3MINT-65854 I2D: score=5 
    VIMP086702, 3MINT-65855 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ISS--
    GO:0008283cell proliferation ISS--
    GO:0031053primary miRNA processing IMP19632182
    GO:0046685response to arsenic-containing substance NAS11239002

    SRRT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRRT

    Search CenterWatch for drugs/clinical trials and news about SRRT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRRT gene (5 alternative transcripts): 
    NM_182800.2  NM_001128852.1  NM_001128853.1  NM_001128854.1  NM_015908.5  

    Unigene Cluster for SRRT:

    Serrate RNA effector molecule homolog (Arabidopsis)
    Hs.111801  [show with all ESTs]
    Unigene Representative Sequence: NM_015908
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473047 ENST00000457580(uc003uxa.2 uc003uwz.2) ENST00000388793(uc010lhl.1 uc003uwy.2)
    ENST00000448716 ENST00000432932 ENST00000347433 ENST00000431645 ENST00000423692
    ENST00000474896 ENST00000460194 ENST00000448764 ENST00000449389 ENST00000466432
    ENST00000487311 ENST00000469602 ENST00000478693 ENST00000445337 ENST00000477529

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRRT
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SRRT
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SRRT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRT
    Clone
    Products:
         
    OriGene clones in human, mouse for SRRT (see all 22)
    OriGene ORF clones in mouse, rat for SRRT
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): SRRT (NM_001128854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRT
    Sirion Biotech Customized lentivirus for stable overexpression of SRRT 
                         Customized lentivirus expression plasmids for stable overexpression of SRRT 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SRRT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRRT
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRT

    Additional mRNA sequence: 

    AF082871.1 AF112994.1 AF248955.1 AK296131.1 AK302820.1 AK311728.1 AL096723.1 BC000082.2 
    BC069249.1 BC109116.1 BC109117.1 

    24 DOTS entries:

    DT.87017455  DT.102834112  DT.100816896  DT.120398  DT.92445924  DT.100816898  DT.215325  DT.95313627 
    DT.121050654  DT.95323020  DT.95323029  DT.95361719  DT.97777794  DT.121050640  DT.121050659  DT.121050666 
    DT.449009  DT.91954045  DT.92445902  DT.95104632  DT.95323021  DT.95323023  DT.97864514  DT.92020880 

    24/428 AceView cDNA sequences (see all 428):

    BM745474 CA441959 AW770857 BM552596 BU689305 BQ777580 CA307449 H85856 
    H85928 NM_015908 AL527779 AF082871 BM792788 BM053021 AA371977 CR615585 
    AW236623 BE397196 BM723086 BU733881 AA760735 BE675611 BQ003547 AW450315 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for SRRT (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:  -                 -           -           -                       -                                                         
    SP2:                    -           -           -                       -                             -                           
    SP3:  -                 -           -                                                                                             
    SP4:  -                 -           -                                                                                             
    SP5:  -                 -           -           -                                                                                 


    ECgene alternative splicing isoforms for SRRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRRT expression in normal human tissues (normalized intensities)      SRRT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCGTATGG
    SRRT Expression
    About this image


    SRRT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Testis (Reproductive System)

    See SRRT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRRT

    SOURCE GeneReport for Unigene cluster: Hs.111801

    UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for SRRT
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SRRT
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SRRT
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRT
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRRT gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srrt1 , 5 serrate RNA effector molecule homolog (Arabidopsis)1, 5 88.57(n)1
    97.83(a)1
      5 (76.33 cM)5
    837011  NM_031405.21  NP_113582.11 
     1372957045 
    lizard
    (Anolis carolinensis)
    Reptilia SRRT6
    serrate RNA effector molecule homolog (Arabidopsis...
    81(a)
    1 ↔ 1
    GL343939.1(21-31399)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985422 similar to arsenate resistance protein 2 75.54(n)    BC041542.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ars22 arsenate resistance protein 2 77.82(n)   192311  AF506224.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ars21 Ars2 53.97(n)
    49.08(a)
      35539  NM_136359.2  NP_610203.2 
    worm
    (Caenorhabditis elegans)
    Secernentea E01A2.21 Protein E01A2.2 51.34(n)
    48.02(a)
      171996  NM_058901.3  NP_491302.1 


    ENSEMBL Gene Tree for SRRT (if available)
    TreeFam Gene Tree for SRRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/566 SNPs in SRRT are shown (see all 566)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3752837301,2
    C--103776751(+) GCCTCA/GCTTCT 4 -- us2k10--------
    rs2010907381,2
    --103776788(+) GCCATC/TGCGCC 4 -- us2k10--------
    rs617489471,2
    C,F--103776852(+) AGGGCG/AAGTGT 4 -- us2k12Minor allele frequency- A:0.00NS NA 4620
    rs1446615521,2
    C--103776905(+) TGCAGC/TGCCTG 4 -- us2k11Minor allele frequency- T:0.00NA 4552
    rs1386134371,2
    F--103776932(+) TCAGCC/TACCGT 4 -- us2k11Minor allele frequency- T:0.00NA 4552
    rs1434291071,2
    --103776961(+) CTTCCC/TAGAAG 4 -- us2k10--------
    rs1143244021,2
    C,F--103776984(+) TCTCAG/ATTCCA 4 -- us2k11Minor allele frequency- A:0.04WA 118
    rs733966401,2
    C,F--103777022(+) CCTGAC/TATCCA 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs67061,2
    C,F,A,H--103777072(+) CCAATC/TAAGAA 4 -- us2k118Minor allele frequency- T:0.15MN NS EA NA 2474
    rs125382871,2
    C,F,H--103777149(+) CATTAC/AAGGCC 4 -- us2k119Minor allele frequency- A:0.24NS EA NA CSA WA 2344

    HapMap Linkage Disequilibrium report for SRRT (100472701 - 100486285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SRRT:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv5870CNV Insertion18451855
    dgv7403n71CNV Loss21882294
    dgv7404n71CNV Loss21882294
    nsv831073CNV Loss17160897
    dgv7402n71CNV Loss21882294
    dgv2119e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SRRT
    DNA2.0 Custom Variant and Variant Library Synthesis for SRRT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614469    OMIM disorders: --

    9 diseases for SRRT:    About MalaCards
    spondylocostal dysostosis    resting heart rate    cadasil    dysostosis
    alagille syndrome    pancreatic cancer    sarcoma    pancreatitis
    neuronitis


    SRRT for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRRT

    Export disorders for SRRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRRT gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with SRRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2, 3 Wilson M.D....Koop B.F. (2001)
    3. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PubMed id 19546234)1, 2, 9 Kiriyama M.... Yonehara S. (2009)
    4. Genome-wide association analysis identifies multiple loci related to resting heart rate. (PubMed id 20639392)1, 4 Eijgelsheim M....O'Donnell C.J. (2010)
    5. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. (PubMed id 19632182)1, 2 Gruber J.J.... Thompson C.B. (2009)
    6. ARS2 is a conserved eukaryotic gene essential for early mammalian development. (PubMed id 18086880)1, 2 Wilson M.D....Howard P.L. (2008)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51593 HGNC: 24101 AceView: ARS2 Ensembl:ENSG00000087087 euGenes: HUgn51593
    ECgene: SRRT H-InvDB: SRRT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRRT gene:
    Search GeneIP for patents involving SRRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SRRT
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SRRT  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SRRT  
     OriGene MassSpec something-or-other for SRRT   OriGene clones in human, mouse for SRRT  
     OriGene qSTAR qPCR primer pairs in human, mouse for SRRT   OriGene Purified Protein for SRRT  
     OriGene ORF clones in mouse, rat for SRRT   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SRRT   OriGene Custom Protein Services for SRRT  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRRT
     QIAGEN SeqTarget long-range PCR primers for resequencing SRRT
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRT
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRT
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRT
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRT
     GenScript Custom Purified and Recombinant Proteins Services for SRRT GenScript cDNA clones with any tag delivered in your preferred vector for SRRT
     GenScript Custom Assay Services for SRRT GenScript Custom Superior Antibodies Services for SRRT
     GenScript Custom overexpressing Cell Line Services for SRRT CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SRRT promoter
     Search Chromatin IP Primers for SRRT
     RT2 qPCR Primer Assay in human, mouse, rat SRRT
     Search GNC Networks for SRRT
     SABiosciences Custom PCR Arrays for SRRT
     Search Tocris compounds for SRRT
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SRRT antibodies
     SRRT proteins
     SRRT lysates
     Antibodies for SRRT
     See all of Abcam's Antibodies, Kits and Proteins for SRRT
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SRRT
     Antibodies for SRRT
     ELISAs for SRRT
     CLIAs for SRRT
     Search LifeMap BioReagents cell lines for SRRT
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRT
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SRRT
     SwitchGear Promoter luciferase reporter plasmids for SRRT
     ThermoFisher Antibody for SRRT
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRT
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SRRT
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SRRT
    Customized:
     lentivirus for stable overexpression of SRRT
     lentivirus expression plasmids for stable overexpression of SRRT
     adenovirus for overexpression of SRRT
     LSBio Antibodies in human, mouse, rat for SRRT
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SRRT gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4