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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRRT Gene

protein-coding   GIFtS: 49
GCID: GC07P100472

serrate RNA effector molecule homolog (Arabidopsis)

 Explore 8 diseases affiliated with
SRRT via our new
 Human Malady Compendium 
Biological research products
for SRRT
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Serrate RNA Effector Molecule Homolog (Arabidopsis)1 2     Asr21
ARS21 2 3     Arsenate Resistance Protein 22
Serrate1     Arsenate Resistance Protein ARS22
Arsenite-Resistance Protein 22 3     Arsenite Resistance Protein2
ASR22 3     Serrate RNA Effector Molecule Homolog2

External Ids:    HGNC: 241011   Entrez Gene: 515932   Ensembl: ENSG000000870877   OMIM: 6144695   UniProtKB: Q9BXP53   

Export aliases for SRRT gene to outside databases

Previous GC identifers: GC07P100311 GC07P095103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
Function: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing
machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to
the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene
silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its
interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not
directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs,
necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and
positively regulating its transcription (By similarity)

Gene Wiki entry for SRRT (ARS2)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRRT gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SRRT promoter sequence
   Search SABiosciences Chromatin IP Primers for SRRT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q21

SRRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRT gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100472:  view genomic region     (about GC identifiers)

Start:
100,472,701 bp from pter      End:
100,486,285 bp from pter
Size:
13,585 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,832,306-99,845,890     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5 (See protein sequence)
Recommended Name: Serrate RNA effector molecule homolog  
Size: 876 amino acids; 100666 Da
Subunit: Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4
Subcellular location: Nucleus, nucleoplasm (By similarity). Cytoplasm (By similarity). Note=Predominantly nuclear.
Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity)
Sequence caution: Sequence=AAD17774.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAM00189.1; Type=Frameshift; Positions=102; Sequence=BAG58876.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=EAL23816.1; Type=Erroneous gene model prediction;
Secondary accessions: A4D2E5 A4D2E6 A6NK22 B4DJL4 B4DZA6 O95808 Q32MI4 Q6NT74 Q8TDQ5 Q9BWP6 Q9BXP4
Q9Y4S4
Alternative splicing: 5 isoforms:  Q9BXP5-1   Q9BXP5-2   Q9BXP5-3   Q9BXP5-4   Q9BXP5-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRRT: NX_Q9BXP5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BXP5

  • SRRT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001122324.1  NP_001122325.1  NP_001122326.1  NP_056992.4  

    ENSEMBL proteins: 
     ENSP00000416553   ENSP00000373445   ENSP00000402025   ENSP00000391852   ENSP00000314491  
     ENSP00000400912   ENSP00000396807   ENSP00000410588   ENSP00000400703   ENSP00000398618  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: SRRT
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    Novus Biologicals SRRT Protein
    Novus Biologicals SRRT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SRRT

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm ISS--
    GO:0005737cytoplasm ISS--


    SRRT for ontologies           About GeneDecksing



    SRRT Antibody Products: 
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    Search ThermoFisher Antibodies for SRRT

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    Uscn ELISAs and CLIAs for SRRT


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SRRT for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007042 Arsenite-R_2
     IPR021933 DUF3546

    Graphical View of Domain Structure for InterPro Entry Q9BXP5

    ProtoNet protein and cluster: Q9BXP5

    1 Blocks protein family: IPB007042 Arsenite-resistance protein 2

    UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
    Similarity: Belongs to the ARS2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
    Function: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing
    machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to
    the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene
    silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its
    interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not
    directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs,
    necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and
    positively regulating its transcription (By similarity)

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRRT
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRRT (see all 7)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 4): SRRT (NM_001128854)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRT 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRT

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI--


    SRRT for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for SRRT:
     Decreased POU5F1-GFP protein e  Decreased viability  G0/1 arrest  Increased G1 DNA content 
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-outs for SRRT: Srrttm1Bfk Srrttm1.2Thsn
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Srrt):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    SRRT for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/34 Interacting proteins for SRRT (Q9BXP51, 2, 3 ENSP000003144914) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3A2Q154282, 3, ENSP000002214944MINT-5206034 I2D: score=1 STRING: ENSP00000221494
    CHD3Q128732, 3MINT-65857 I2D: score=5 
    GIT1Q9Y2X72, 3MINT-65856 I2D: score=5 
    IMMTQ168912, 3MINT-65854 I2D: score=5 
    VIMP086702, 3MINT-65855 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ISS--
    GO:0008283cell proliferation ISS--
    GO:0031053primary miRNA processing IMP19632182
    GO:0046685response to arsenic-containing substance NAS11239002


    SRRT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRRT
    Search CenterWatch for drugs/clinical trials and news about SRRT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRRT gene (5 alternative transcripts): 
    NM_182800.2  NM_001128852.1  NM_001128853.1  NM_001128854.1  NM_015908.5  

    Unigene Cluster for SRRT:

    Serrate RNA effector molecule homolog (Arabidopsis)
    Hs.111801  [show with all ESTs]
    Unigene Representative Sequence: NM_015908
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473047 ENST00000457580(uc003uxa.2 uc003uwz.2) ENST00000388793(uc010lhl.1 uc003uwy.2)
    ENST00000448716 ENST00000432932 ENST00000347433 ENST00000431645 ENST00000423692
    ENST00000474896 ENST00000460194 ENST00000448764 ENST00000449389 ENST00000466432
    ENST00000487311 ENST00000469602 ENST00000478693 ENST00000445337 ENST00000477529


    miRNA
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    OriGene 3'-UTR Clone (see all 4): SRRT
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRRT
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRRT
    OriGene shRNA RFP: SRRT
    OriGene siRNA: SRRT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRT
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): SRRT (NM_001128854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRT 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRT
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRT

    Additional cDNA sequence: 

    AF082871.1 AF112994.1 AF248955.1 AK296131.1 AK302820.1 AK311728.1 AL096723.1 BC000082.2 
    BC069249.1 BC109116.1 BC109117.1 

    24 DOTS entries:

    DT.87017455  DT.102834112  DT.100816896  DT.120398  DT.92445924  DT.100816898  DT.215325  DT.95313627 
    DT.121050654  DT.95323020  DT.95323029  DT.95361719  DT.97777794  DT.121050640  DT.121050659  DT.121050666 
    DT.449009  DT.91954045  DT.92445902  DT.95104632  DT.95323021  DT.95323023  DT.97864514  DT.92020880 

    24/428 AceView cDNA sequences (see all 428):

    NM_182800 BM973847 CD370406 AI823947 BC000082 BM723086 BE397196 AW236623 
    AA371977 CR615585 AI478326 BM981619 CR610730 CA443853 AI203376 CD367768 
    BU630537 BE675611 AA361486 CF529899 BQ003547 AW450315 AA760735 AI654926 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for SRRT (see all 20)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
    SP1:  -                 -           -           -                       -                                                         
    SP2:                    -           -           -                       -                             -                           
    SP3:  -                 -           -                                                                                             
    SP4:  -                 -           -                                                                                             
    SP5:  -                 -           -           -                                                                                 


    ECgene alternative splicing isoforms for SRRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCCGTATGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SRRT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRRT

    SOURCE GeneReport for Unigene cluster: Hs.111801

    UniProtKB/Swiss-Prot: SRRT_HUMAN, Q9BXP5
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for SRRT
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRRT gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srrt1 , 5 serrate RNA effector molecule homolog (Arabidopsis)1, 5 88.57(n)1
    97.83(a)1
      5 (76.33 cM)5
    837011  NM_031405.21  NP_113582.11 
     1372957045 
    lizard
    (Anolis carolinensis)
    Reptilia SRRT6
    --
    79(a)
    1 ↔ 1
    GL343939.1(964-31399)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985422 similar to arsenate resistance protein 2 75.54(n)    BC041542.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ars22 arsenate resistance protein 2 77.82(n)   192311  AF506224.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ars21 Ars2 53.97(n)
    49.08(a)
      35539  NM_136359.2  NP_610203.2 
    worm
    (Caenorhabditis elegans)
    Secernentea E01A2.21 Protein E01A2.2 51.34(n)
    48.02(a)
      171996  NM_058901.3  NP_491302.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SE6
    serrate RNA effector molecule
    19(a)
    1 ↔ 1
    2(11572550-11576658)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    ZOS2-03 - C2H2 zinc finger protein, expressed
    (see all 3)
    18(a)
    18(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    6(29356514-29363557)
    2(2728846-2734452)


    ENSEMBL Gene Tree for SRRT (if available)
    TreeFam Gene Tree for SRRT (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/367 NCBI SNPs in SRRT are shown (see all 367    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs77942161,2
    C,F,A,--95104213(+) aatggC/Tgcaat 3 -- int13Minor allele frequency- T:0.33NA 6
    rs785358861,2
    F--95104328(-) TAAAAC/ATACAA 3 -- int11Minor allele frequency- A:0.50NA 4
    rs749335231,2
    C--95104352(+) TTCACC/TATGTT 3 -- int13Minor allele frequency- T:0.00NA 6
    rs1115429351,2
    F,--95104565(+) GAGGTC/TGTCAG 3 -- int12Minor allele frequency- T:0.50CSA 4
    rs782828151,2
    --95104995(+) TAGGGG/TGTCTC 3 -- int10--------
    rs1131576061,2
    --95105522(+) TTTTTT/AAAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1121133001,2
    --95106138(+) AACCTG/ATCTGT 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs24661661,2
    --95106184(-) tacagC/Gcatgt 3 -- int10--------
    rs1118627911,2
    C,--95106198(+) CCGGCA/CACTCC 3 -- int12Minor allele frequency- C:0.06WA 120
    rs1136194481,2
    --95106447(+) TAATCC/AAGGTC 3 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for SRRT (100472701 - 100486285 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for SRRT
         7 CNVs: 82113 3692 94747 82111 94748 94746 82112
         1 Indel: 94749

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SRRT for disorders           About GeneDecksing

    OMIM gene information: 614469    OMIM disorders: --

    8 diseases for SRRT:    About MalaCards
    spondylocostal dysostosis    dysostosis    alagille syndrome    cadasil
    sarcoma    pancreatic cancer    pancreatitis    neuronitis


    Export disorders for SRRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRRT gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with SRRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PubMed id 11239002)1, 2, 3 Wilson M.D....Koop B.F. (2001)
    3. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PubMed id 19546234)1, 2, 9 Kiriyama M.... Yonehara S. (2009)
    4. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. (PubMed id 19632182)1, 2 Gruber J.J.... Thompson C.B. (2009)
    5. ARS2 is a conserved eukaryotic gene essential for early mammalian development. (PubMed id 18086880)1, 2 Wilson M.D....Howard P.L. (2008)
    6. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51593 HGNC: 24101 AceView: ARS2 Ensembl:ENSG00000087087 euGenes: HUgn51593
    ECgene: SRRT H-InvDB: SRRT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRRT gene:
    Search GeneIP for patents involving SRRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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