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Aliases for SRRT Gene

Aliases for SRRT Gene

  • Serrate, RNA Effector Molecule 2 3 5
  • Arsenite-Resistance Protein 2 3 4
  • Arsenite Resistance Protein 2 3
  • ARS2 3 4
  • ASR2 3 4
  • Serrate RNA Effector Molecule Homolog (Arabidopsis) 2
  • Serrate RNA Effector Molecule Homolog 3
  • Arsenate Resistance Protein ARS2 3
  • Arsenate Resistance Protein 2 3
  • Serrate 3

External Ids for SRRT Gene

Previous GeneCards Identifiers for SRRT Gene

  • GC07P100311
  • GC07P100472
  • GC07P095103

Summaries for SRRT Gene

GeneCards Summary for SRRT Gene

SRRT (Serrate, RNA Effector Molecule) is a Protein Coding gene. Diseases associated with SRRT include Alagille Syndrome 1. Among its related pathways are RNA polymerase II transcribes snRNA genes and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SRRT Gene

  • Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Gene Wiki entry for SRRT Gene

Additional gene information for SRRT Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRT Gene

Genomics for SRRT Gene

Regulatory Elements for SRRT Gene

Enhancers for SRRT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H100475 1.4 ENCODE dbSUPER 86 -397.2 -397217 4.4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZSCAN25 TRIM4 GIGYF1 ZNF3 ZNF655 SRRT AP4M1 ENSG00000242798 STAG3L5P PILRA
GH07H100427 1.5 ENCODE dbSUPER 75.2 -441.8 -441772 10.8 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZC3H11A ZSCAN25 SRRT GIGYF1 TRIM4 AP4M1 PILRA LOC100131859 ZNF3 PPP1R35 ZSCAN21
GH07H100672 1.4 ENCODE dbSUPER 64.8 -198.0 -197979 8.6 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 ZC3H11A MEF2D TRIM4 ZNF3 GIGYF1 SRRT PCOLCE STAG3L5P PPP1R35 ENSG00000242798 AP4M1 ZAN
GH07H100835 1.9 FANTOM5 Ensembl ENCODE dbSUPER 46.2 -38.1 -38136 2.5 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 CBX5 ZNF143 SP3 SRRT TRIM4 ZNF3 GIGYF1 STAG3L5P AP4M1 ENSG00000242798 PPP1R35 MEPCE PILRB
GH07H101116 2 FANTOM5 Ensembl ENCODE dbSUPER 40.9 +248.8 248773 15.1 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS ENSG00000242798 GIGYF1 SRRT STAG3L5P PCOLCE-AS1 PILRB PPP1R35 SERPINE1 MBLAC1 MEPCE
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRRT on UCSC Golden Path with GeneCards custom track

Promoters for SRRT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215866 329 1401 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Locations for SRRT Gene

Genomic Locations for SRRT Gene
chr7:100,874,971-100,888,664
(GRCh38/hg38)
Size:
13,694 bases
Orientation:
Plus strand
chr7:100,472,701-100,486,285
(GRCh37/hg19)

Genomic View for SRRT Gene

Genes around SRRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRT Gene

Proteins for SRRT Gene

  • Protein details for SRRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXP5-SRRT_HUMAN
    Recommended name:
    Serrate RNA effector molecule homolog
    Protein Accession:
    Q9BXP5
    Secondary Accessions:
    • A4D2E5
    • A4D2E6
    • A6NK22
    • B4DJL4
    • B4DZA6
    • O95808
    • Q32MI4
    • Q6NT74
    • Q8TDQ5
    • Q9BWP6
    • Q9BXP4
    • Q9Y4S4

    Protein attributes for SRRT Gene

    Size:
    876 amino acids
    Molecular mass:
    100666 Da
    Quaternary structure:
    • Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4. Interacts with LUZP4. Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858).
    SequenceCaution:
    • Sequence=AAD17774.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM00189.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305}; Sequence=BAG58876.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL23816.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SRRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRT Gene

Post-translational modifications for SRRT Gene

  • Ubiquitination at Lys153, posLast=476476, and posLast=758758
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SRRT Gene

Domains & Families for SRRT Gene

Gene Families for SRRT Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SRRT Gene

Suggested Antigen Peptide Sequences for SRRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXP5

UniProtKB/Swiss-Prot:

SRRT_HUMAN :
  • Belongs to the ARS2 family.
Family:
  • Belongs to the ARS2 family.
genes like me logo Genes that share domains with SRRT: view

Function for SRRT Gene

Molecular function for SRRT Gene

UniProtKB/Swiss-Prot Function:
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Phenotypes From GWAS Catalog for SRRT Gene

Gene Ontology (GO) - Molecular Function for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,ISS --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 17500595
genes like me logo Genes that share ontologies with SRRT: view
genes like me logo Genes that share phenotypes with SRRT: view

Animal Models for SRRT Gene

MGI Knock Outs for SRRT:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRRT Gene

Localization for SRRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRT Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRT gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm ISS --
GO:0043234 protein complex IDA 23793891
genes like me logo Genes that share ontologies with SRRT: view

Pathways & Interactions for SRRT Gene

genes like me logo Genes that share pathways with SRRT: view

Gene Ontology (GO) - Biological Process for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0008283 cell proliferation IEA,ISS --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with SRRT: view

No data available for SIGNOR curated interactions for SRRT Gene

Drugs & Compounds for SRRT Gene

No Compound Related Data Available

Transcripts for SRRT Gene

Unigene Clusters for SRRT Gene

Serrate RNA effector molecule homolog (Arabidopsis):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - -
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18: -
SP19: -
SP20:

Relevant External Links for SRRT Gene

GeneLoc Exon Structure for
SRRT
ECgene alternative splicing isoforms for
SRRT

Expression for SRRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRRT Gene

This gene is overexpressed in Lymph node (15.8) and Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRRT Gene



Protein tissue co-expression partners for SRRT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRRT Gene:

SRRT

SOURCE GeneReport for Unigene cluster for SRRT Gene:

Hs.111801

mRNA Expression by UniProt/SwissProt for SRRT Gene:

Q9BXP5-SRRT_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SRRT Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Kidney(4.3)
  • Lung(3.1)
  • Skin(2.3)
  • Bone marrow(2.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with SRRT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRT Gene

Orthologs for SRRT Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRT 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia SRRT 33 34
  • 90.52 (n)
cow
(Bos Taurus)
Mammalia SRRT 33 34
  • 90.38 (n)
oppossum
(Monodelphis domestica)
Mammalia SRRT 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrt 33 16 34
  • 87.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SRRT 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRT 34
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398542 33
zebrafish
(Danio rerio)
Actinopterygii srrt 34
  • 70 (a)
OneToOne
ars2 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10964 33
fruit fly
(Drosophila melanogaster)
Insecta Ars2 33 34
  • 55.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta SRRT_ANOGA 33
  • 52.85 (n)
worm
(Caenorhabditis elegans)
Secernentea E01A2.2 33 34
  • 52.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.208 34
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2711 33
Species where no ortholog for SRRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRT Gene

ENSEMBL:
Gene Tree for SRRT (if available)
TreeFam:
Gene Tree for SRRT (if available)

Paralogs for SRRT Gene

No data available for Paralogs for SRRT Gene

Variants for SRRT Gene

Sequence variations from dbSNP and Humsavar for SRRT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000487700 -- 100,879,015(+) AGTGG(C/T)GTGAT intron-variant
rs1000793942 -- 100,876,624(+) AAAAT(C/G/T)TCAGA intron-variant
rs1001214408 -- 100,885,554(+) TGTTC(C/T)GAAGC intron-variant
rs1001462526 -- 100,888,307(+) CCATG(-/C)CCCCG downstream-variant-500B, reference, frameshift-variant
rs1001618762 -- 100,875,302(+) AGCGC(C/G)AGTCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SRRT Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
esv2759547 CNV gain+loss 17122850
nsv1020837 CNV loss 25217958
nsv5870 CNV insertion 18451855
nsv607965 CNV loss 21841781
nsv607966 CNV loss 21841781
nsv607967 CNV loss 21841781
nsv607968 CNV loss 21841781
nsv831073 CNV loss 17160897

Variation tolerance for SRRT Gene

Residual Variation Intolerance Score: 4.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRT Gene

Disorders for SRRT Gene

MalaCards: The human disease database

(1) MalaCards diseases for SRRT Gene - From: DISEASES

Disorder Aliases PubMed IDs
alagille syndrome 1
  • alagille syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SRRT in MalaCards View complete list of genes associated with diseases

Relevant External Links for SRRT

Genetic Association Database (GAD)
SRRT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRT
genes like me logo Genes that share disorders with SRRT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SRRT Gene

Publications for SRRT Gene

  1. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PMID: 19546234) Kiriyama M … Yonehara S (Molecular and cellular biology 2009) 3 4 22 60
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 60
  3. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson MD … Koop BF (Nucleic acids research 2001) 2 3 4 60
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N … Wilson SA (Nucleic acids research 2015) 3 4 60
  5. mRNA export through an additional cap-binding complex consisting of NCBP1 and NCBP3. (PMID: 26382858) Gebhardt A … Pichlmair A (Nature communications 2015) 3 4 60

Products for SRRT Gene

Sources for SRRT Gene

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