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Aliases for SRRT Gene

Aliases for SRRT Gene

  • Serrate, RNA Effector Molecule 2 3 5
  • Arsenite-Resistance Protein 2 3 4
  • Arsenite Resistance Protein 2 3
  • ARS2 3 4
  • ASR2 3 4
  • Serrate RNA Effector Molecule Homolog (Arabidopsis) 2
  • Arsenate Resistance Protein ARS2 3
  • Arsenate Resistance Protein 2 3
  • Serrate 3

External Ids for SRRT Gene

Previous GeneCards Identifiers for SRRT Gene

  • GC07P100311
  • GC07P100472
  • GC07P095103

Summaries for SRRT Gene

GeneCards Summary for SRRT Gene

SRRT (Serrate, RNA Effector Molecule) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SRRT Gene

  • Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Gene Wiki entry for SRRT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRT Gene

Genomics for SRRT Gene

Regulatory Elements for SRRT Gene

Enhancers for SRRT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SRRT on UCSC Golden Path with GeneCards custom track

Promoters for SRRT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SRRT on UCSC Golden Path with GeneCards custom track

Genomic Location for SRRT Gene

Chromosome:
7
Start:
100,874,971 bp from pter
End:
100,888,664 bp from pter
Size:
13,694 bases
Orientation:
Plus strand

Genomic View for SRRT Gene

Genes around SRRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRT Gene

Proteins for SRRT Gene

  • Protein details for SRRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXP5-SRRT_HUMAN
    Recommended name:
    Serrate RNA effector molecule homolog
    Protein Accession:
    Q9BXP5
    Secondary Accessions:
    • A4D2E5
    • A4D2E6
    • A6NK22
    • B4DJL4
    • B4DZA6
    • O95808
    • Q32MI4
    • Q6NT74
    • Q8TDQ5
    • Q9BWP6
    • Q9BXP4
    • Q9Y4S4

    Protein attributes for SRRT Gene

    Size:
    876 amino acids
    Molecular mass:
    100666 Da
    Quaternary structure:
    • Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4. Interacts with LUZP4. Interacts with NCBP2/CBP20 and NCBP3 (PubMed:26382858).
    SequenceCaution:
    • Sequence=AAD17774.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM00189.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305}; Sequence=BAG58876.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL23816.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SRRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRT Gene

Proteomics data for SRRT Gene at MOPED

Post-translational modifications for SRRT Gene

  • Ubiquitination at Lys 153, Lys 476, and Lys 758
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SRRT Gene

Domains & Families for SRRT Gene

Protein Domains for SRRT Gene

Suggested Antigen Peptide Sequences for SRRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXP5

UniProtKB/Swiss-Prot:

SRRT_HUMAN :
  • Belongs to the ARS2 family.
Family:
  • Belongs to the ARS2 family.
genes like me logo Genes that share domains with SRRT: view

No data available for Gene Families for SRRT Gene

Function for SRRT Gene

Molecular function for SRRT Gene

UniProtKB/Swiss-Prot Function:
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Gene Ontology (GO) - Molecular Function for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA,ISS --
genes like me logo Genes that share ontologies with SRRT: view
genes like me logo Genes that share phenotypes with SRRT: view

Animal Models for SRRT Gene

MGI Knock Outs for SRRT:

Animal Model Products

CRISPR Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SRRT Gene

Localization for SRRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRT Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRRT Gene COMPARTMENTS Subcellular localization image for SRRT gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SRRT Gene

Pathways & Interactions for SRRT Gene

genes like me logo Genes that share pathways with SRRT: view

Interacting Proteins for SRRT Gene

Gene Ontology (GO) - Biological Process for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008283 cell proliferation IEA,ISS --
GO:0031053 primary miRNA processing IEA,IMP 19632182
GO:0050769 positive regulation of neurogenesis IEA --
GO:0097150 neuronal stem cell population maintenance IEA,ISS --
genes like me logo Genes that share ontologies with SRRT: view

No data available for SIGNOR curated interactions for SRRT Gene

Drugs & Compounds for SRRT Gene

No Compound Related Data Available

Transcripts for SRRT Gene

Unigene Clusters for SRRT Gene

Serrate RNA effector molecule homolog (Arabidopsis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - -
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18: -
SP19: -
SP20:

Relevant External Links for SRRT Gene

GeneLoc Exon Structure for
SRRT
ECgene alternative splicing isoforms for
SRRT

Expression for SRRT Gene

mRNA expression in normal human tissues for SRRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRRT Gene

This gene is overexpressed in Lymph node (15.8) and Nasal epithelium (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SRRT Gene



SOURCE GeneReport for Unigene cluster for SRRT Gene Hs.111801

mRNA Expression by UniProt/SwissProt for SRRT Gene

Q9BXP5-SRRT_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with SRRT: view

Protein tissue co-expression partners for SRRT Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SRRT Gene

Orthologs for SRRT Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRRT 35
  • 90.38 (n)
  • 97.18 (a)
SRRT 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRT 35
  • 90.52 (n)
  • 98.59 (a)
SRRT 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrt 35
  • 87.99 (n)
  • 97.04 (a)
Srrt 16
Srrt 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRT 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRT 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SRRT 36
  • 100 (a)
OneToOne
SRRT 35
  • 99.37 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia SRRT 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398542 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10964 35
zebrafish
(Danio rerio)
Actinopterygii srrt 36
  • 70 (a)
OneToOne
ars2 35
African malaria mosquito
(Anopheles gambiae)
Insecta SRRT_ANOGA 35
  • 52.85 (n)
  • 50.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ars2 35
  • 55.72 (n)
  • 52.59 (a)
Ars2 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01A2.2 35
  • 52.63 (n)
  • 49.54 (a)
E01A2.2 36
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2711 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.208 36
  • 39 (a)
OneToOne
Species with no ortholog for SRRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRT Gene

ENSEMBL:
Gene Tree for SRRT (if available)
TreeFam:
Gene Tree for SRRT (if available)

Paralogs for SRRT Gene

No data available for Paralogs for SRRT Gene

Variants for SRRT Gene

Sequence variations from dbSNP and Humsavar for SRRT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6954151 -- 100,887,296(+) ACCTT(C/T)CTTCC intron-variant
rs12667888 -- 100,876,668(+) AGATG(C/T)GGTTA intron-variant
rs12669120 -- 100,878,489(+) TTTAA(C/T)GCAGC intron-variant
rs12672665 -- 100,886,110(+) GACGG(A/G)ACCTA intron-variant
rs12705091 -- 100,874,758(+) GCGCC(C/T)GCGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRRT Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv2119e1 CNV Complex 17122850
dgv7402n71 CNV Loss 21882294
dgv7403n71 CNV Loss 21882294
nsv831073 CNV Loss 17160897
nsv5870 CNV Insertion 18451855
dgv7404n71 CNV Loss 21882294

Variation tolerance for SRRT Gene

Residual Variation Intolerance Score: 4.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRT Gene

HapMap Linkage Disequilibrium report
SRRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRT Gene

Disorders for SRRT Gene

Relevant External Links for SRRT

Genetic Association Database (GAD)
SRRT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRT

No disorders were found for SRRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRT Gene

Publications for SRRT Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PMID: 19546234) Kiriyama M. … Yonehara S. (Mol. Cell. Biol. 2009) 3 23
  3. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson M.D. … Koop B.F. (Nucleic Acids Res. 2001) 2 3
  4. Low expressions of ARS2 and CASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblastic leukemia patients treated on China CCLG-ALL 2008 protocol. (PMID: 25530566) Cui L. … Jia H.T. (Leuk. Res. 2015) 3
  5. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3

Products for SRRT Gene

Sources for SRRT Gene

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