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Aliases for SRRT Gene

Aliases for SRRT Gene

  • Serrate, RNA Effector Molecule 2 3
  • ARS2 3 4 6
  • Arsenite-Resistance Protein 2 3 4
  • Arsenite Resistance Protein 2 3
  • ASR2 3 4
  • Serrate RNA Effector Molecule Homolog (Arabidopsis) 2
  • Serrate RNA Effector Molecule Homolog 3
  • Arsenate Resistance Protein ARS2 3
  • Arsenate Resistance Protein 2 3
  • Serrate 3

External Ids for SRRT Gene

Summaries for SRRT Gene

GeneCards Summary for SRRT Gene

SRRT (Serrate, RNA Effector Molecule) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SRRT Gene

  • Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Gene Wiki entry for SRRT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRT Gene

Genomics for SRRT Gene

Genomic Location for SRRT Gene

Start:
100,875,079 bp from pter
End:
100,888,664 bp from pter
Size:
13,586 bases
Orientation:
Plus strand

Genomic View for SRRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRT Gene

Regulatory Elements for SRRT Gene

Proteins for SRRT Gene

  • Protein details for SRRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXP5-SRRT_HUMAN
    Recommended name:
    Serrate RNA effector molecule homolog
    Protein Accession:
    Q9BXP5
    Secondary Accessions:
    • A4D2E5
    • A4D2E6
    • A6NK22
    • B4DJL4
    • B4DZA6
    • O95808
    • Q32MI4
    • Q6NT74
    • Q8TDQ5
    • Q9BWP6
    • Q9BXP4
    • Q9Y4S4

    Protein attributes for SRRT Gene

    Size:
    876 amino acids
    Molecular mass:
    100666 Da
    Quaternary structure:
    • Interacts with NCBP1 and DROSHA (By similarity). Interacts with CASP8AP2 and ERBB4.
    SequenceCaution:
    • Sequence=AAD17774.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM00189.1; Type=Frameshift; Positions=102; Evidence={ECO:0000305}; Sequence=BAG58876.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL23816.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SRRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRT Gene

Proteomics data for SRRT Gene at MOPED

Post-translational modifications for SRRT Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys153, Lys476, Lys526, and Lys758

No data available for DME Specific Peptides for SRRT Gene

Domains for SRRT Gene

Protein Domains for SRRT Gene

UniProtKB/Swiss-Prot:

SRRT_HUMAN
Family:
  • Belongs to the ARS2 family.:
    • Q9BXP5
genes like me logo Genes that share domains with SRRT: view

No data available for Gene Families for SRRT Gene

Function for SRRT Gene

Molecular function for SRRT Gene

UniProtKB/Swiss-Prot Function: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity).

Gene Ontology (GO) - Molecular Function for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IPI 17500595
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with SRRT: view
genes like me logo Genes that share phenotypes with SRRT: view

Animal Models for SRRT Gene

MGI Knock Outs for SRRT:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRRT Gene

Localization for SRRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRT Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRRT Gene COMPARTMENTS Subcellular localization image for SRRT gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with SRRT: view

Pathways for SRRT Gene

SuperPathways for SRRT Gene

No Data Available

Interacting Proteins for SRRT Gene

Gene Ontology (GO) - Biological Process for SRRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0008283 cell proliferation ISS --
GO:0031053 primary miRNA processing IMP 19632182
GO:0046685 response to arsenic-containing substance NAS 11239002
genes like me logo Genes that share ontologies with SRRT: view

No data available for Pathways by source for SRRT Gene

Transcripts for SRRT Gene

Unigene Clusters for SRRT Gene

Serrate RNA effector molecule homolog (Arabidopsis):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRRT Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - - - - - - - - - - - -
SP11: - -
SP12: -
SP13: - -
SP14:
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:

ExUns: 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c · 20d ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18: -
SP19: -
SP20:

Relevant External Links for SRRT Gene

GeneLoc Exon Structure for
SRRT
ECgene alternative splicing isoforms for
SRRT

Expression for SRRT Gene

mRNA expression in normal human tissues for SRRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SRRT Gene

SOURCE GeneReport for Unigene cluster for SRRT Gene Hs.111801

mRNA Expression by UniProt/SwissProt for SRRT Gene

Q9BXP5-SRRT_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with SRRT: view

Orthologs for SRRT Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRT 36
  • 99.37 (n)
  • 100 (a)
SRRT 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRRT 36
  • 90.38 (n)
  • 97.18 (a)
SRRT 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRT 36
  • 90.52 (n)
  • 98.59 (a)
SRRT 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrt 36
  • 87.99 (n)
  • 97.04 (a)
Srrt 16
Srrt 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRT 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRT 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRT 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398542 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10964 36
zebrafish
(Danio rerio)
Actinopterygii ars2 36
srrt 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta SRRT_ANOGA 36
  • 52.85 (n)
  • 50.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ars2 36
  • 55.72 (n)
  • 52.59 (a)
Ars2 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E01A2.2 36
  • 52.63 (n)
  • 49.54 (a)
E01A2.2 37
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2711 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.208 37
  • 39 (a)
OneToOne
Species with no ortholog for SRRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRT Gene

ENSEMBL:
Gene Tree for SRRT (if available)
TreeFam:
Gene Tree for SRRT (if available)

Paralogs for SRRT Gene

No data available for Paralogs for SRRT Gene

Variants for SRRT Gene

Sequence variations from dbSNP and Humsavar for SRRT Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9735 -- 100,881,375(+) CGCCA(A/C)GAACT missense, reference, upstream-variant-2KB
rs15624 -- 100,884,405(-) ATGCG(A/G)AGATC synonymous-codon, reference
rs2466166 -- 100,878,186(-) tacag(C/G)catgt intron-variant
rs2720395 -- 100,883,145(-) AACCA(C/G/T)GAGTG intron-variant
rs3757863 -- 100,883,189(+) GCTCT(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRT Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv2119e1 CNV Complex 17122850
dgv7402n71 CNV Loss 21882294
dgv7403n71 CNV Loss 21882294
nsv831073 CNV Loss 17160897
nsv5870 CNV Insertion 18451855
dgv7404n71 CNV Loss 21882294

Relevant External Links for SRRT Gene

HapMap Linkage Disequilibrium report
SRRT

Disorders for SRRT Gene

Relevant External Links for SRRT

Genetic Association Database (GAD)
SRRT
genes like me logo Genes that share disorders with SRRT: view

No data available for UniProtKB/Swiss-Prot for SRRT Gene

Publications for SRRT Gene

  1. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase. (PMID: 19546234) Kiriyama M. … Yonehara S. (Mol. Cell. Biol. 2009) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. (PMID: 11239002) Wilson M.D. … Koop B.F. (Nucleic Acids Res. 2001) 2 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SRRT Gene

Sources for SRRT Gene

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