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Aliases for SRRM5 Gene

Aliases for SRRM5 Gene

  • Serine/Arginine Repetitive Matrix 5 2 3 5
  • ZNF576 3 4
  • Serine/Arginine Repetitive Matrix Protein 5 3
  • Zinc Finger Protein 576 3

External Ids for SRRM5 Gene

Previous GeneCards Identifiers for SRRM5 Gene

  • GC19P044116
  • GC19P040547

Summaries for SRRM5 Gene

GeneCards Summary for SRRM5 Gene

SRRM5 (Serine/Arginine Repetitive Matrix 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM5 Gene

Genomics for SRRM5 Gene

Regulatory Elements for SRRM5 Gene

Enhancers for SRRM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F043560 1.3 FANTOM5 Ensembl ENCODE 27.3 -33.6 -33643 4.5 CBX3 KLF17 ZBTB40 RAD21 ZNF23 GLIS2 FOS ZNF391 EGR2 SMARCA5 ZNF575 SRRM5 IRGQ ZNF180 CEACAMP10 LOC105372414 CEACAMP1 ENSG00000267614 ETHE1 PLAUR
GH19F043462 0.9 ENCODE 24.6 -132.1 -132085 3.6 HDGF ATF1 PKNOX1 ZNF133 SIN3A ZNF48 YY1 GLIS2 ZNF416 KLF7 PINLYP SRRM5 ZNF575 ZNF45 PHLDB3 ZNF225 ZNF223 CEACAMP10 LOC105372414 CEACAMP1
GH19F043594 0.7 ENCODE 14.4 -0.2 -222 4.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 ZNF45 ZNF234 ZNF180 ZNF225 PINLYP MRPS15P2 ZNF223 CEACAMP10 LOC105372414 ENSG00000267614
GH19F043607 0.4 Ensembl 14 +11.1 11084 0.6 PKNOX1 ZNF133 ZNF2 ZNF23 GLIS2 ZNF366 ZNF416 KLF7 EGR2 SP3 ZNF45 ZNF180 ZNF284 CEACAMP10 LOC105372414 ENSG00000267614 CEACAMP1 ZNF224 SRRM5 ZNF234
GH19F043618 1.2 FANTOM5 ENCODE 14 +23.0 23042 2.6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF45 ZNF180 ZNF224 ZNF234 ZNF284 ZNF225 XRCC1 ZNF223 ZNF230 CEACAMP10
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SRRM5 on UCSC Golden Path with GeneCards custom track

Promoters for SRRM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216847 -517 3001 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302
ENSR00001817886 1383 401 ZNF680

Genomic Location for SRRM5 Gene

Chromosome:
19
Start:
43,596,617 bp from pter
End:
43,614,498 bp from pter
Size:
17,882 bases
Orientation:
Plus strand

Genomic View for SRRM5 Gene

Genes around SRRM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM5 Gene

Proteins for SRRM5 Gene

  • Protein details for SRRM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B3KS81-SRRM5_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 5
    Protein Accession:
    B3KS81
    Secondary Accessions:
    • B4DNF0

    Protein attributes for SRRM5 Gene

    Size:
    715 amino acids
    Molecular mass:
    80355 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG60212.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SRRM5 Gene

Post-translational modifications for SRRM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRRM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRM5 Gene

Domains & Families for SRRM5 Gene

Protein Domains for SRRM5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SRRM5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SRRM5: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SRRM5 Gene

Function for SRRM5 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SRRM5 Gene

Localization for SRRM5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRRM5 Gene COMPARTMENTS Subcellular localization image for SRRM5 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRRM5 Gene

Pathways & Interactions for SRRM5 Gene

SuperPathways for SRRM5 Gene

No Data Available

Interacting Proteins for SRRM5 Gene

Gene Ontology (GO) - Biological Process for SRRM5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SRRM5 Gene

Transcripts for SRRM5 Gene

mRNA/cDNA for SRRM5 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SRRM5 Gene

Serine/arginine repetitive matrix 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM5 Gene

No ASD Table

Relevant External Links for SRRM5 Gene

GeneLoc Exon Structure for
SRRM5
ECgene alternative splicing isoforms for
SRRM5

Expression for SRRM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRRM5 Gene

mRNA expression in normal human tissues for SRRM5 Gene

Protein differential expression in normal tissues from HIPED for SRRM5 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SRRM5 Gene



Protein tissue co-expression partners for SRRM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SRRM5 Gene:

SRRM5

SOURCE GeneReport for Unigene cluster for SRRM5 Gene:

Hs.722032
genes like me logo Genes that share expression patterns with SRRM5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRRM5 Gene

Orthologs for SRRM5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SRRM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF576 34
  • 98.43 (n)
SRRM5 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM5 34
  • 75.91 (n)
dog
(Canis familiaris)
Mammalia SRRM5 35
  • 57 (a)
OneToOne
Species where no ortholog for SRRM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SRRM5 Gene

ENSEMBL:
Gene Tree for SRRM5 (if available)
TreeFam:
Gene Tree for SRRM5 (if available)

Paralogs for SRRM5 Gene

(1) SIMAP similar genes for SRRM5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SRRM5: view

No data available for Paralogs for SRRM5 Gene

Variants for SRRM5 Gene

Sequence variations from dbSNP and Humsavar for SRRM5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1008148 -- 43,611,806(+) accca(C/T)tgact intron-variant, upstream-variant-2KB
rs10408803 -- 43,613,506(+) TCATA(C/G)CCGAT intron-variant, reference, missense
rs10410000 -- 43,613,430(+) GAGAT(C/T)GCAGC intron-variant, reference, missense
rs111904462 -- 43,614,268(+) GGCGT(A/G)GCCCC reference, missense, stop-lost
rs112021635 -- 43,614,227(+) ACCTT(A/G/T)CCTGG reference, synonymous-codon, missense, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM5 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV loss 17160897

Variation tolerance for SRRM5 Gene

Gene Damage Index Score: 8.74; 86.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM5 Gene

Disorders for SRRM5 Gene

Relevant External Links for SRRM5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRM5

No disorders were found for SRRM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM5 Gene

Publications for SRRM5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for SRRM5 Gene

Sources for SRRM5 Gene

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