Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SRRM4 Gene

protein-coding GIFtS: 45
GCID: GC12P119420

serine/arginine repetitive matrix 4

(Previous name: KIAA1853 )
(Previous symbol: KIAA1853)

Explore 7 diseases affiliated with
SRRM4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Serine/Arginine Repetitive Matrix 4¹ ²		Neural-Specific SR-Related Protein Of 100 KDa² ³
KIAA1853¹ ² ³ ⁵		MU-MB-2.76²
NSR100⁵		Serine/Arginine Repetitive Matrix Protein 4²
Medulloblastoma Antigen MU-MB-2.76² ³		NSR100⁵
Neural-Specific Serine/Arginine Repetitive Splicing Factor Of 100 KDa² ³

External Ids:	HGNC: 29389¹	Entrez Gene: 84530²	Ensembl: ENSG00000139767⁷	OMIM: 613103⁵	UniProtKB: A7MD48³

Export aliases for SRRM4 gene to outside databases

Previous GC identifers: GC12P117903 GC12P116428

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SRRM4:

SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009

(PubMed 19737518)).(supplied by OMIM, Oct 2009)

UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48

Function: Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by

binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that

function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2,

leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in

neuron extracts (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009775.17

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SRRM4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SRRM4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRM4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23 Ensembl cytogenetic band: 12q24.23 HGNC cytogenetic band: 12q24.23

SRRM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRM4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P119420: view genomic region (about GC identifiers)

Start:	119,419,300 bp from pter	End:	119,600,857 bp from pter
Size:	181,558 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48 (See protein sequence)

Recommended Name: Serine/arginine repetitive matrix protein 4

Size: 611 amino acids; 68559 Da

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAB47482.1; Type=Erroneous initiation;

Secondary accessions: A8K5P6 B2RZH7 Q7Z5F0 Q96JH4

Explore the universe of human proteins at neXtProt for SRRM4: NX_A7MD48

Post-translational modifications:

Phosphorylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A7MD48

SRRM4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_919262.2

ENSEMBL proteins:

ENSP00000267260

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for SRRM4
	GenScript Custom Purified and Recombinant Proteins Services for SRRM4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SRRM4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--

SRRM4 for ontologies About GeneDecksing

SRRM4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SRRM4
	GenScript Custom Superior Antibodies Services for SRRM4
	Novus Biologicals SRRM4 Antibody
	Search for Antibodies for SRRM4 at Abcam
	Uscn Antibodies for SRRM4
	Search ThermoFisher Antibodies for SRRM4

Assay Products for SRRM4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SRRM4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SRRM4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: A7MD48

UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48

Similarity: Belongs to the nSR100 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48

Function: Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by

binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that

function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2,

leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in

neuron extracts (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: SRRM4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRRM4
		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate SRRM4 (see all 86):
		hsa-miR-4254 hsa-miR-3194-5p hsa-miR-146a hsa-miR-134 hsa-miR-3921 hsa-miR-298 hsa-miR-149 hsa-miR-200b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRRM4 OriGene shRNA RFP: SRRM4 OriGene siRNA: SRRM4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRM4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SRRM4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SRRM4 (NM_194286)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRM4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRM4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SRRM4
		Search LifeMap BioReagents cell lines for SRRM4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003729	mRNA binding	ISS	--

SRRM4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SRRM4:

Decreased POU5F1-GFP protein e

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SRRM4

1 Interacting protein for SRRM4 (A7MD48³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CACNA1A	O00555³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006397	mRNA processing	ISS	--
GO:0007399	nervous system development	ISS	--
GO:0008380	RNA splicing	IEA	--
GO:0030154	cell differentiation	ISS	--
GO:0043484	regulation of RNA splicing	ISS	--

SRRM4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SRRM4
Search CenterWatch for drugs/clinical trials and news about SRRM4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SRRM4 gene:

NM_194286.3

Unigene Cluster for SRRM4:

Serine/arginine repetitive matrix 4

Hs.112577 [show with all ESTs]

Unigene Representative Sequence: NM_194286

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000267260(uc001txa.2) ENST00000545224 ENST00000537597

miRNA Products:		OriGene 3'-UTR Clone: SRRM4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SRRM4
		8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate SRRM4 (see all 86):
		hsa-miR-4254 hsa-miR-3194-5p hsa-miR-146a hsa-miR-134 hsa-miR-3921 hsa-miR-298 hsa-miR-149 hsa-miR-200b

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRRM4 OriGene shRNA RFP: SRRM4 OriGene siRNA: SRRM4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRM4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SRRM4 (NM_194286)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRM4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRM4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRRM4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SRRM4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRM4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRM4

Additional cDNA sequence:

AB058756.1 AK055717.1 AK125400.1 AK291361.1 AY130006.1 BC152471.1 BC167162.1 BC167163.1

1 DOTS entry:

DT.306671

24/64 AceView cDNA sequences (see all 64):

BQ719476 AI701523 AB058756 AA324027 R12793 BX281343 NM_194286 BM672974

AA608629 BE218946 BX488955 BM723637 AI887860 F23308 AW594642 AL707158

BF062141 BM927278 R87586 AW962002 CA976031 BQ070814 BM686798 AW071669

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SRRM4 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4
SP1:							-
SP2:							-
SP3:

ECgene alternative splicing isoforms for SRRM4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SRRM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATGGTGTT

About this image

SRRM4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Bone

Maxillary Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SRRM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRRM4

SOURCE GeneReport for Unigene cluster: Hs.112577

UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48

Tissue specificity: Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum

SABiosciences Custom PCR Arrays for SRRM4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRRM4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SRRM4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRM4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRM4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SRRM4 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SRRM4¹	serine/arginine repetitive matrix 4	68.19(n) 64.97(a)		416989 XM_415281.3 XP_415281.3
lizard (Anolis carolinensis)	Reptilia	SRRM4⁶	--	47(a)	1 ↔ 1	GL343338.1(531384-577332)
zebrafish (Danio rerio)	Actinopterygii	srrm4¹	serine/arginine repetitive matrix 4	47.69(n) 44.4(a)		796574 XM_001336887.2 XP_001336923.2
honey bee (Apis mellifera)	Insecta	--	--	9(a)	possible ortholog	GroupUn.1473(11966-15820)
worm (Caenorhabditis elegans)	Secernentea	C15C6.3⁶	Protein C15C6.3	8(a)	1 ↔ 1	I(12207086-12212197)

ENSEMBL Gene Tree for SRRM4 (if available)
TreeFam Gene Tree for SRRM4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SRRM4 gene

SRRM3² SRRM2² SRRM1² C2orf16² SRRM5²

SRRM4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10851058^1,2	C,F,A,H,	--	119417341(+)	`GTTTTG/TCATAT`	1	--	us2k¹ tfbs³		9		NS EA NA WA	542
rs11069211^1,2	C,F,A,H,	--	119417417(+)	`GTGGGG/AGTAGG`	1	--	us2k¹		8		NS EA NA CSA	648
rs143822789^1,2		--	119417465(+)	`TACCCC/TAAATG`	1	--	us2k¹		0	--	--	--	--
rs12309500^1,2	C,F,A,H,	--	119417567(+)	`GGAAAC/TGGGGG`	1	--	us2k¹		10		NS EA NA WA CSA	650
rs76104818^1,2	F,	--	119417707(+)	`TCCCCC/AGGCAA`	1	--	us2k¹		1		WA	118
rs182831005^1,2		--	119417713(+)	`GGCAAC/GCCACA`	1	--	us2k¹		0	--	--	--	--
rs148137244^1,2		--	119417739(+)	`TGCACC/TTCTCG`	1	--	us2k¹		0	--	--	--	--
rs115803219^1,2	F,	--	119417746(+)	`CTCGTT/CGTTGA`	1	--	us2k¹		1		WA	118
rs79697587^1,2	C,F,	--	119417812(+)	`GCAGGC/TGTGTC`	1	--	us2k¹		1		WA	118
rs141970136^1,2		--	119417845(+)	`GATACA/CCTTTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SRRM4 (119419300 - 119600857 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SRRM4
1 CNV: 1933

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRRM4

DNA2.0 Custom Variant and Variant Library Synthesis for SRRM4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SRRM4 for disorders           About GeneDecksing

OMIM gene information: 613103    OMIM disorders: --

7 diseases for SRRM4:    About MalaCards

medulloblastoma large cell medulloblastoma childhood medulloblastoma macular degeneration

ataxia malaria neuronitis

Human Genome Epidemiology (HuGE) Navigator: SRRM4 (1 document)

Export disorders for SRRM4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SRRM4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SRRM4)

Utopia: connect your pdf to the dynamic
world of online information

Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. (PubMed id 19737518)^{1, 2, 3} Calarco J.A.... Blencowe B.J. (2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)^{1, 2} Behrends U.... Mautner J. (2003)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84530	HGNC: 29389	AceView: KIAA1853	Ensembl:ENSG00000139767	euGenes: HUgn84530
ECgene: SRRM4	H-InvDB: SRRM4

(According to HUGE)
About This Section

HUGE: KIAA1853

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SRRM4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SRRM4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SRRM4 gene:
Search GeneIP for patents involving SRRM4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SRRM4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRRM4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRRM4
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SRRM4		OriGene 3'-UTR Clone for SRRM4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SRRM4		OriGene Custom Protein Services for SRRM4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRRM4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRRM4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRM4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRM4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRM4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRM4

	GenScript Custom Purified and Recombinant Proteins Services for SRRM4		GenScript cDNA clones with any tag delivered in your preferred vector for SRRM4
	GenScript Custom Assay Services for SRRM4		GenScript Custom Superior Antibodies Services for SRRM4
	GenScript Custom overexpressing Cell Line Services for SRRM4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for SRRM4
	Search Chromatin IP Primers for SRRM4
	RT² qPCR Primer Assay in human, mouse, rat SRRM4
	Search GNC Networks for SRRM4
	SABiosciences Custom PCR Arrays for SRRM4

Search Tocris compounds for SRRM4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SRRM4 antibodies

	Search for Antibodies for SRRM4 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SRRM4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SRRM4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SRRM4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM4

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SRRM4
	Browse SwitchGear Promoter luciferase reporter plasmids for SRRM4

Search ThermoFisher Antibodies for SRRM4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRM4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SRRM4 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SRRM4 Gene

serine/arginine repetitive matrix 4

Aliases
for SRRM4 gene

Summaries
for SRRM4 gene

Genomic Views
for SRRM4 gene

Proteins
for SRRM4 gene

Protein Domains /
Families
for SRRM4 gene

Function
for SRRM4 gene

Pathways & Interactions
for SRRM4 gene

Drugs & Compounds
for SRRM4 gene

Transcripts
for SRRM4 gene

Expression
for SRRM4 gene

Orthologs
for SRRM4 gene

Paralogs
for SRRM4 gene

Genomic Variants
for SRRM4 gene

Disorders / Diseases
for SRRM4 gene

Publications
for SRRM4 gene

External Searches for SRRM4 gene

Genome Databases showing SRRM4 gene

Other Databases showing SRRM4 gene

Specialized Databases showing SRRM4 gene

Intellectual Property
for SRRM4 gene

Products
for SRRM4 gene

View Random Gene

Advanced Search

Export list of displayed genes

SRRM4 Gene

serine/arginine repetitive matrix 4

Aliasesfor SRRM4 gene

Summariesfor SRRM4 gene

Genomic Viewsfor SRRM4 gene

Proteinsfor SRRM4 gene

Protein Domains /Familiesfor SRRM4 gene

Functionfor SRRM4 gene

Pathways & Interactionsfor SRRM4 gene

Drugs & Compoundsfor SRRM4 gene

Transcriptsfor SRRM4 gene

Expression for SRRM4 gene

Orthologsfor SRRM4 gene

Paralogsfor SRRM4 gene

Genomic Variantsfor SRRM4 gene

Disorders / Diseasesfor SRRM4 gene

Publicationsfor SRRM4 gene

External Searches for SRRM4 gene

Genome Databases showing SRRM4 gene

Other Databases showing SRRM4 gene

Specialized Databases showing SRRM4 gene

Intellectual Propertyfor SRRM4 gene

Productsfor SRRM4 gene

View Random Gene

Aliases
for SRRM4 gene

Summaries
for SRRM4 gene

Genomic Views
for SRRM4 gene

Proteins
for SRRM4 gene

Protein Domains /
Families
for SRRM4 gene

Function
for SRRM4 gene

Pathways & Interactions
for SRRM4 gene

Drugs & Compounds
for SRRM4 gene

Transcripts
for SRRM4 gene

Expression
for SRRM4 gene

Orthologs
for SRRM4 gene

Paralogs
for SRRM4 gene

Genomic Variants
for SRRM4 gene

Disorders / Diseases
for SRRM4 gene

Publications
for SRRM4 gene

Intellectual Property
for SRRM4 gene

Products
for SRRM4 gene