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SRRM4 Gene

protein-coding   GIFtS: 43
GCID: GC12P119420

Serine/Arginine Repetitive Matrix 4

(Previous name: KIAA1853)
(Previous symbol: KIAA1853)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine Repetitive Matrix 41 2     nSR1002 3
KIAA18531 2 3 5     MU-MB-2.762
Neural-Specific SR-Related Protein Of 100 KDa1 2 3     Serine/Arginine Repetitive Matrix Protein 42
Medulloblastoma Antigen MU-MB-2.762 3     NSR1005
Neural-Specific Serine/Arginine Repetitive Splicing Factor Of 100 KDa2 3     

External Ids:    HGNC: 293891   Entrez Gene: 845302   Ensembl: ENSG000001397677   OMIM: 6131035   UniProtKB: A7MD483   

Export aliases for SRRM4 gene to outside databases

Previous GC identifers: GC12P117903 GC12P116428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SRRM4 Gene:
SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009
(PubMed 19737518)).(supplied by OMIM, Oct 2009)

GeneCards Summary for SRRM4 Gene:
SRRM4 (serine/arginine repetitive matrix 4) is a protein-coding gene. Diseases associated with SRRM4 include large cell medulloblastoma, and medulloblastoma. GO annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48
Function: Splicing factor specifically required for neural cell differentiation. Acts in conjuction with
nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in
many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific
exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion
of exon 16 in DAAM1 in neuron extracts (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for SRRM4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SRRM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRRM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.23   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q24.23

SRRM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRM4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P119420:  view genomic region     (about GC identifiers)

Start:
119,419,300 bp from pter      End:
119,600,856 bp from pter
Size:
181,557 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48 (See protein sequence)
Recommended Name: Serine/arginine repetitive matrix protein 4  
Size: 611 amino acids; 68559 Da
Sequence caution: Sequence=BAB47482.1; Type=Erroneous initiation;
Secondary accessions: A8K5P6 B2RZH7 Q7Z5F0 Q96JH4

Explore the universe of human proteins at neXtProt for SRRM4: NX_A7MD48

Explore proteomics data for SRRM4 at MOPED

Post-translational modifications: 

  • Phosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SRRM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_919262.2  
    ENSEMBL proteins: 
     ENSP00000267260  

    SRRM4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SRRM4

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    LSBio Antibodies in human, mouse, rat for SRRM4

    SRRM4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for SRRM4
    Cloud-Clone Corp. CLIAs for SRRM4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: A7MD48

    UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48
    Similarity: Belongs to the nSR100 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRRM4_HUMAN, A7MD48
    Function: Splicing factor specifically required for neural cell differentiation. Acts in conjuction with
    nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in
    many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific
    exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion
    of exon 16 in DAAM1 in neuron extracts (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding ISS--
         
    SRRM4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SRRM4:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Srrm4):
     behavior/neurological  hearing/vestibular/ear  nervous system 

    SRRM4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SRRM4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRRM4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRRM4

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRRM4 (see all 86):
    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-146a hsa-miR-134 hsa-miR-3921 hsa-miR-298 hsa-miR-149 hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRRM4

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRM4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRRM4_HUMAN, A7MD48: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--

    SRRM4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRRM4
    Interactions:

        Search GeneGlobe Interaction Network for SRRM4

    1 Interacting protein for SRRM4 (A7MD483) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA1AO005553I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IEA--
    GO:0006397mRNA processing ISS--
    GO:0007399nervous system development ISS--
    GO:0007605sensory perception of sound IEA--
    GO:0008380RNA splicing IEA--

    SRRM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRRM4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SRRM4 gene: 
    NM_194286.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267260(uc001txa.2) ENST00000545224 ENST00000537597
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRRM4 (see all 86):
    hsa-miR-4254 hsa-miR-3194-5p hsa-miR-146a hsa-miR-134 hsa-miR-3921 hsa-miR-298 hsa-miR-149 hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRRM4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRM4
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRRM4
      QuantiTect SYBR Green Assays in human, mouse, rat SRRM4
      QuantiFast Probe-based Assays in human, mouse, rat SRRM4

    Selected AceView cDNA sequences (see all 64):

    BM927278 BF062141 BQ719476 AI701523 AI887860 F23308 AA324027 AA608629 
    BX488955 BE218946 NM_194286 BM723637 BM672974 R12793 BX281343 AB058756 
    AW594642 AL707158 AK125400 R87586 AI636249 AY130006 AW071669 BQ070814 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SRRM4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
    SP1:                    -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for SRRM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRRM4 expression in normal human tissues (normalized intensities)      SRRM4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATGGTGTT
    SRRM4 Expression
    About this image


    SRRM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
    SRRM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRRM4 Protein Expression

    UniProtKB/Swiss-Prot: SRRM4_HUMAN, A7MD48
    Tissue specificity: Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum

        Custom PCR Arrays for SRRM4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SRRM4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srrm41 , 5 serine/arginine repetitive matrix 41, 5 85.2(n)1
    86.49(a)1
      5 (56.45 cM)5
    689551  NM_026886.31  NP_081162.11 
     1164392725 
    chicken
    (Gallus gallus)
    Aves SRRM41 serine/arginine repetitive matrix 4 66.02(n)
    61.55(a)
      416989  XM_415281.4  XP_415281.4 
    lizard
    (Anolis carolinensis)
    Reptilia SRRM46
    serine/arginine repetitive matrix 4
    53(a)
    1 ↔ 1
    GL343338.1(529368-577332)
    zebrafish
    (Danio rerio)
    Actinopterygii SRRM46
    serine/arginine repetitive matrix 4
    52(a)
    1 ↔ 1
    5(3628103-3643715) ENSDARG00000096920


    ENSEMBL Gene Tree for SRRM4 (if available)
    TreeFam Gene Tree for SRRM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRRM4 (see all 3990)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3734794581,2
    C--119211691(+) CCCAA-/CCCCCCCC 1 -- us2k10--------
    rs108510581,2
    C,F,A,H--119417341(+) GTTTTG/TCATAT 1 -- us2k1 tfbs39Minor allele frequency- T:0.10NS EA NA WA 542
    rs110692111,2
    C,F,A,H--119417417(+) GTGGGG/AGTAGG 1 -- us2k18Minor allele frequency- A:0.12NS EA NA CSA 648
    rs1438227891,2
    --119417465(+) TACCCC/TAAATG 1 -- us2k10--------
    rs123095001,2
    C,F,A,H--119417567(+) GGAAAC/TGGGGG 1 -- us2k110Minor allele frequency- T:0.24NS EA NA WA CSA 650
    rs761048181,2
    C,F--119417707(+) TCCCCC/AGGCAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1828310051,2
    --119417713(+) GGCAAC/GCCACA 1 -- us2k10--------
    rs1481372441,2
    --119417739(+) TGCACC/TTCTCG 1 -- us2k10--------
    rs1158032191,2
    C,F--119417746(+) CTCGTT/CGTTGA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs796975871,2
    C,F--119417812(+) GCAGGC/TGTGTC 1 -- us2k11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for SRRM4 (119419300 - 119600856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SRRM4 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746456CNV Deletion23290073
    esv2659059CNV Deletion23128226
    esv2665881CNV Deletion23128226
    esv2669850CNV Deletion23128226
    nsv455725CNV Loss19166990
    dgv309n67CNV Loss20364138
    nsv902CNV Loss18451855
    nsv521985CNV Loss19592680
    nsv438238CNV Loss16468122
    nsv529044CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRRM4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613103    OMIM disorders: --

    7 diseases for SRRM4:    About MalaCards
    large cell medulloblastoma    medulloblastoma    childhood medulloblastoma    ataxia
    obesity    endotheliitis    neuronitis


    SRRM4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SRRM4
    Human Genome Epidemiology (HuGE) Navigator: SRRM4 (1 document)

    Export disorders for SRRM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRRM4 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with SRRM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein. (PubMed id 19737518)1, 2, 3 Calarco J.A.... Blencowe B.J. (Cell 2009)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries. (PubMed id 12800201)1, 2 Behrends U.... Mautner J. (Int. J. Cancer 2003)
    5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    6. The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100). (PubMed id 23928058)1 Shimojo M.... Ito S. (Mol. Cancer Res. 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84530 HGNC: 29389 AceView: KIAA1853 Ensembl:ENSG00000139767 euGenes: HUgn84530
    ECgene: SRRM4 H-InvDB: SRRM4

    (According to HUGE)
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    HUGE: KIAA1853

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SRRM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRRM4 gene:
    Search GeneIP for patents involving SRRM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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