Aliases for SRRM4 Gene
External Ids for SRRM4 Gene
Previous HGNC Symbols for SRRM4 Gene
Previous GeneCards Identifiers for SRRM4 Gene
SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]
GeneCards Summary for SRRM4 Gene
SRRM4 (Serine/Arginine Repetitive Matrix 4) is a Protein Coding gene. Diseases associated with SRRM4 include Medulloblastoma. GO annotations related to this gene include mRNA binding.
UniProtKB/Swiss-Prot for SRRM4 Gene
Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity).