SRRM3 Gene
protein-coding GIFtS: 38
GCID: GC07P075831
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|
serine/arginine repetitive matrix 3
| |
Aliases
for SRRM3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine/Arginine Repetitive Matrix 31 2 | | FLJ370781 | | Serine/Arginine Repetitive Matrix Protein 32 | | SRRM2-Like Protein2 |
Export aliases for SRRM3 gene to outside databasesPrevious GC identifers: GC07P075752 GC07P070917 |
Summaries
for SRRM3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SRRM3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for SRRM3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRRM3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRM3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23SRRM3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P075831: view genomic region
(about GC identifiers)
Start:
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75,831,216 bp from pter |
End:
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75,916,605 bp from pter |
Size:
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85,390 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 75,164,280-75,249,669 |
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Proteins
for SRRM3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SRRM3_HUMAN, A6NNA2 (See
protein sequence)Recommended Name: Serine/arginine repetitive matrix protein 3 Size: 597 amino acids; 65249 Da
Secondary accessions: A6ND75Explore the universe of human proteins at neXtProt for SRRM3: NX_A6NNA2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NNA2
SRRM3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001103669.1
ENSEMBL proteins: ENSP00000325298 ENSP00000410209 ENSP00000373454
Human Recombinant Protein Products:
SRRM3 Antibody Products:
Assay Products for SRRM3: |
Protein
Domains /
Families
for SRRM3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRRM3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NNA2ProtoNet protein and cluster: A6NNA2 UniProtKB/Swiss-Prot: SRRM3_HUMAN, A6NNA2Similarity: Belongs to the CWC21 family |
Function
for SRRM3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SRRM3 (NM_001110199) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRRM3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SRRM3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM3 |
1 GenomeRNAi human phenotype for SRRM3:
|
Pathways & Interactions
for SRRM3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRRM3
|
Drugs & Compounds
for SRRM3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SRRM3
Search CenterWatch for drugs/clinical trials and news about SRRM3
|
Transcripts
for SRRM3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SRRM3 gene (2 alternative transcripts): NM_001110199.1 NM_001039212.1 Unigene Cluster for SRRM3: Serine/arginine repetitive matrix 3 Hs.511025 [show with all ESTs]Unigene Representative Sequence: NM_0011101996 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326382 ENST00000479294 ENST00000464752(uc011kgi.2) ENST00000479284
ENST00000413003(uc003uet.1) ENST00000388802(uc010ldi.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SRRM3 (NM_001110199) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SRRM3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SRRM3 |
Additional cDNA sequence: AK092590.1 AK094397.1 BC029292.1 BC063788.1 BC071856.1 BC096755.1 BC141904.1 5 DOTS entries: DT.97763781 DT.97793074 DT.405787 DT.65288766 DT.95328808 24/56 AceView cDNA sequences (see all 56): BM714195 BE858467 BM717942 BE223041 AK094397 BF593867 AK092590 BM699369 BM725697 BU742027 NM_153043 CR623032 AX747617 BU599474 AW136649 CA502814 BM926319 BQ278985 BI870131 BU857028 BE729804 BI823549 BE408952 BM723979
GeneLoc Exon Structure
|
Expression
for SRRM3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SRRM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGTCTTCCT
About this image
See SRRM3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SRRM3
SOURCE GeneReport for Unigene cluster: Hs.511025
SABiosciences Custom PCR Arrays for SRRM3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRRM3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SRRM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRM3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM3 |
Orthologs
for SRRM3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SRRM3 gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SRRM31 |
serine/arginine repetitive matrix 3 |
68.31(n)
63.49(a) |
|
417516 XM_415764.3 XP_415764.3 |
lizard
(Anolis carolinensis) |
Reptilia |
SRRM36 |
-- |
44(a) |
1 ↔ 1 |
GL343734.1(23205-60842) |
zebrafish
(Danio rerio) |
Actinopterygii |
srrm26 |
serine/arginine repetitive matrix 2 |
8(a) |
possible ortholog |
3(32768346-32787254) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG79716 |
-- |
6(a) |
possible ortholog |
3L(1654247-1665064) |
worm
(Caenorhabditis elegans) |
Secernentea |
rsr-26 |
SR protein related family member (rsr-2) |
13(a) |
possible ortholog |
II(12225294-12227227) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G496016 |
uncharacterized protein |
12(a) |
1 → many |
3(18387302-18389564) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
9(a) |
1 → many |
4(30657619-30661227) |
ENSEMBL Gene Tree for SRRM3 (if available)
TreeFam Gene Tree for SRRM3 (if available) |
Paralogs
for SRRM3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SRRM3 gene
- SRRM22 SRRM42 SRRM12 C2orf162 SRRM52
1 SIMAP similar gene for SRRM3 using alignment to 3 protein entries: SRRM3_HUMAN (see all proteins):SRRM2
SRRM3 for paralogs About GeneDecksing
|
Genomic Variants
for SRRM3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SRRM3 (75831216 - 75916605 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SRRM3
3 CNVs: 3686 5241 22956 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SRRM3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRRM3 for disorders About GeneDecksing
1  disease for SRRM3: About MalaCardsmalaria
Export disorders for SRRM3 gene to outside databases
|
Publications
for SRRM3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SRRM3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SRRM3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SRRM3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRRM3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRRM3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRRM3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SRRM3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SRRM3 gene:
Search GeneIP for patents involving SRRM3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRRM3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SRRM3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SRRM3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SRRM3 | | | OriGene Protein Over-expression Lysate for SRRM3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SRRM3 | | OriGene 3'-UTR Clone for SRRM3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SRRM3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SRRM3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SRRM3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRM3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SRRM3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRM3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SRRM3 |
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 |  |  |  | |
| | | | Search Tocris compounds for SRRM3 |
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 | | | SRRM3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM3 |
|  |  |  | | | | Search ThermoFisher Antibodies for SRRM3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SRRM3 |
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