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Aliases for SRRM3 Gene

Aliases for SRRM3 Gene

  • Serine/Arginine Repetitive Matrix 3 2 3 5

External Ids for SRRM3 Gene

Previous GeneCards Identifiers for SRRM3 Gene

  • GC07P075752
  • GC07P075831
  • GC07P070917
  • GC07P076201

Summaries for SRRM3 Gene

GeneCards Summary for SRRM3 Gene

SRRM3 (Serine/Arginine Repetitive Matrix 3) is a Protein Coding gene. An important paralog of this gene is SRRM2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM3 Gene

Genomics for SRRM3 Gene

Regulatory Elements for SRRM3 Gene

Enhancers for SRRM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G076317 2 FANTOM5 Ensembl ENCODE dbSUPER 17 +152.0 152046 3.4 HDGF PKNOX1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 LOC100133091 SRRM3 POMZP3 SPDYE18 UPK3B SSC4D RHBDD2 GC07M076330 GC07P076306 PIR61421
GH07G076290 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +127.9 127880 8.9 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC MEF2D STAG3L1 SRRM3 POMZP3 FAM185BP SPDYE18 ENSG00000250778 STYXL1 ZP3 LOC100133091 RHBDD2
GH07G076325 2.2 ENCODE dbSUPER 10.5 +160.6 160607 2.8 FOXA2 ATF1 MLX ARID4B TCF12 GATA2 FOS ZHX2 REST PPARG POMZP3 SRRM3 ENSG00000250778 GC07M076330 PIR61421 GC07P076306
GH07G076420 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +256.3 256293 5.4 HDGF PKNOX1 FOXA2 SIN3A BRCA1 TCF12 ZNF121 GATA2 FOS ZNF263 UPK3B ZP3 POMZP3 SRRM3 LOC100133091 SSC4D DTX2
GH07G076301 1.7 Ensembl ENCODE dbSUPER 11.4 +140.1 140075 10.2 CREB3L1 ZFP64 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D GLIS1 SPDYE18 STAG3L1 PMS2P9 DTX2P1 FAM185BP POMZP3 SPDYE17 NSUN5P1 LOC100133091 LOC100422695
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRRM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRRM3 Gene

Chromosome:
7
Start:
76,166,675 bp from pter
End:
76,287,292 bp from pter
Size:
120,618 bases
Orientation:
Plus strand

Genomic View for SRRM3 Gene

Genes around SRRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM3 Gene

Proteins for SRRM3 Gene

  • Protein details for SRRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNA2-SRRM3_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 3
    Protein Accession:
    A6NNA2
    Secondary Accessions:
    • A6ND75

    Protein attributes for SRRM3 Gene

    Size:
    597 amino acids
    Molecular mass:
    65249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRRM3 Gene

Post-translational modifications for SRRM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRRM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRM3 Gene

Domains & Families for SRRM3 Gene

Protein Domains for SRRM3 Gene

Suggested Antigen Peptide Sequences for SRRM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NNA2

UniProtKB/Swiss-Prot:

SRRM3_HUMAN :
  • Belongs to the CWC21 family.
Family:
  • Belongs to the CWC21 family.
genes like me logo Genes that share domains with SRRM3: view

No data available for Gene Families for SRRM3 Gene

Function for SRRM3 Gene

genes like me logo Genes that share phenotypes with SRRM3: view

Animal Model Products

CRISPR Products

miRNA for SRRM3 Gene

miRTarBase miRNAs that target SRRM3

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRM3 Gene

Localization for SRRM3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRM3 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytoskeleton 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRRM3 Gene

Pathways & Interactions for SRRM3 Gene

SuperPathways for SRRM3 Gene

No Data Available

Interacting Proteins for SRRM3 Gene

Gene Ontology (GO) - Biological Process for SRRM3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SRRM3 Gene

Drugs & Compounds for SRRM3 Gene

No Compound Related Data Available

Transcripts for SRRM3 Gene

Unigene Clusters for SRRM3 Gene

Serine/arginine repetitive matrix 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM3 Gene

No ASD Table

Relevant External Links for SRRM3 Gene

GeneLoc Exon Structure for
SRRM3
ECgene alternative splicing isoforms for
SRRM3

Expression for SRRM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRM3 Gene

mRNA differential expression in normal tissues according to GTEx for SRRM3 Gene

This gene is overexpressed in Brain - Cerebellum (x10.7) and Brain - Cerebellar Hemisphere (x10.7).

Protein differential expression in normal tissues from HIPED for SRRM3 Gene

This gene is overexpressed in Liver, secretome (38.5), Adipocyte (12.8), Saliva (10.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SRRM3 Gene



NURSA nuclear receptor signaling pathways regulating expression of SRRM3 Gene:

SRRM3

SOURCE GeneReport for Unigene cluster for SRRM3 Gene:

Hs.511025
genes like me logo Genes that share expression patterns with SRRM3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRM3 Gene

Orthologs for SRRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM3 34 35
  • 99.39 (n)
mouse
(Mus musculus)
Mammalia Srrm3 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM3 35
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRM3 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRM3 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM3 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRRM3 35
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM3 35
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii srrm2 35
  • 11 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7971 35
  • 6 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsr-2 35
  • 21 (a)
OneToMany
Species where no ortholog for SRRM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRM3 Gene

ENSEMBL:
Gene Tree for SRRM3 (if available)
TreeFam:
Gene Tree for SRRM3 (if available)

Paralogs for SRRM3 Gene

Paralogs for SRRM3 Gene

(1) SIMAP similar genes for SRRM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRRM3: view

Variants for SRRM3 Gene

Sequence variations from dbSNP and Humsavar for SRRM3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000103910 -- 76,220,092(+) AGCTC(C/G)CATCG intron-variant
rs1000136274 -- 76,261,183(+) AGGGA(A/C)CTTGG intron-variant
rs1000159894 -- 76,228,999(+) GTTCA(A/C/T)GCCAT intron-variant
rs1000201692 -- 76,203,631(+) ATGCC(A/C)AGCTC intron-variant
rs1000254084 -- 76,203,865(+) TGCCA(C/G)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM3 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv3597n106 CNV deletion 24896259
esv2422494 CNV duplication 17116639
esv2734682 CNV deletion 23290073
esv2734684 CNV deletion 23290073
nsv1074520 CNV deletion 25765185
nsv1075974 CNV deletion 25765185
nsv1126797 CNV deletion 24896259
nsv519194 CNV loss 19592680
nsv528969 CNV gain 19592680
nsv955984 CNV deletion 24416366

Variation tolerance for SRRM3 Gene

Gene Damage Index Score: 6.34; 76.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM3 Gene

Disorders for SRRM3 Gene

Relevant External Links for SRRM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRM3

No disorders were found for SRRM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM3 Gene

Publications for SRRM3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SRRM3 Gene

Sources for SRRM3 Gene

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