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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRRM3 Gene

protein-coding   GIFtS: 38
GCID: GC07P075831

Serine/Arginine Repetitive Matrix 3

  Search for SRRM3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Arginine Repetitive Matrix 31 2
Serine/Arginine Repetitive Matrix Protein 32
SRRM2-Like Protein2

External Ids:    HGNC: 267291   Entrez Gene: 2221832   Ensembl: ENSG000001776797   UniProtKB: A6NNA23   

Export aliases for SRRM3 gene to outside databases

Previous GC identifers: GC07P075752 GC07P070917


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SRRM3 Gene: 
SRRM3 (serine/arginine repetitive matrix 3) is a protein-coding gene. An important paralog of this gene is SRRM2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079595.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SRRM3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SRRM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

SRRM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRM3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P075831:  view genomic region     (about GC identifiers)

Start:
75,831,216 bp from pter      End:
75,916,605 bp from pter
Size:
85,390 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 75,164,280-75,249,669     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRRM3_HUMAN, A6NNA2 (See protein sequence)
Recommended Name: Serine/arginine repetitive matrix protein 3  
Size: 597 amino acids; 65249 Da
Secondary accessions: A6ND75

Explore the universe of human proteins at neXtProt for SRRM3: NX_A6NNA2

Explore proteomics data for SRRM3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NNA2

  • SRRM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRRM3 Protein Expression
    REFSEQ proteins: NP_001103669.1  
    ENSEMBL proteins: 
     ENSP00000325298   ENSP00000410209   ENSP00000373454  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013170 mRNA_splic_Cwf21

    Graphical View of Domain Structure for InterPro Entry A6NNA2

    ProtoNet protein and cluster: A6NNA2

    UniProtKB/Swiss-Prot: SRRM3_HUMAN, A6NNA2
    Similarity: Belongs to the CWC21 family


    SRRM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for SRRM3:
     Decreased homologous recombina 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRRM3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRRM3

    Search CenterWatch for drugs/clinical trials and news about SRRM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRRM3 gene (2 alternative transcripts): 
    NM_001110199.1  NM_001039212.1  

    Unigene Cluster for SRRM3:

    Serine/arginine repetitive matrix 3
    Hs.511025  [show with all ESTs]
    Unigene Representative Sequence: NM_001110199
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326382 ENST00000479294 ENST00000464752(uc011kgi.2) ENST00000479284
    ENST00000413003(uc003uet.1) ENST00000388802(uc010ldi.2)
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    hsa-miR-124* hsa-miR-125a-5p hsa-miR-185* hsa-miR-765 hsa-miR-583 hsa-miR-125b hsa-miR-3116 hsa-miR-375
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    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of SRRM3 
                         Customized lentivirus expression plasmids for stable overexpression of SRRM3 
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    Additional mRNA sequence: 

    AK092590.1 AK094397.1 BC029292.1 BC063788.1 BC071856.1 BC096755.1 BC141904.1 

    5 DOTS entries:

    DT.97763781  DT.97793074  DT.405787  DT.65288766  DT.95328808 

    24/56 AceView cDNA sequences (see all 56):

    BE223041 NM_153043 BM725697 BM714195 AX747617 CR623032 AK094397 AK092590 
    BF593867 BM699369 BU742027 BM717942 BE858467 BU857028 F09463 AW136649 
    BU955914 F06237 BQ278985 BQ941465 BI823549 BE729804 BE408952 BC063788 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRRM3 expression in normal human tissues (normalized intensities)      SRRM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTCTTCCT
    SRRM3 Expression
    About this image


    SRRM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retina   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             striatum   
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier

    See SRRM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRRM3

    SOURCE GeneReport for Unigene cluster: Hs.511025
        SABiosciences Custom PCR Arrays for SRRM3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRRM3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srrm31 , 5 serine/arginine repetitive matrix 31, 5 86.68(n)1
    89.81(a)1
      5 (75.42 cM)5
    582121  NM_021403.31  NP_067378.21 
     1358068905 
    chicken
    (Gallus gallus)
    Aves SRRM31 serine/arginine repetitive matrix 3 68.31(n)
    63.49(a)
      417516  XM_415764.3  XP_415764.3 
    lizard
    (Anolis carolinensis)
    Reptilia SRRM36
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL343734.1(20325-60878)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-67c22.26
    srrm26
    (see all 3)
    serine/arginine repetitive matrix 2
    (see all 3)
    9(a)
    8(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    9(36885220-36895301)
    3(32768346-32787254)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79716
    CG16776
    --
    5(a)
    4(a)
    possible ortholog
    possible ortholog
    3L(1654247-1665064)
    X(7175122-7299793)
    worm
    (Caenorhabditis elegans)
    Secernentea C15C6.36
    Protein C15C6.3
    10(a)
    possible ortholog
    I(12207097-12212206)


    ENSEMBL Gene Tree for SRRM3 (if available)
    TreeFam Gene Tree for SRRM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRRM3 gene
    SRRM22  
    1 SIMAP similar gene for SRRM3 using alignment to 3 protein entries:     SRRM3_HUMAN (see all proteins):
    SRRM2

    SRRM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1674 SNPs in SRRM3 are shown (see all 1674)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774305661,2
    C,F--75829216(+) CATACA/GAAGAC 1 -- us2k11Minor allele frequency- G:0.11EA 120
    rs595400631,2
    C,F--75829232(+) ACAAAC/TATACA 1 -- us2k12Minor allele frequency- T:0.06WA 120
    rs1114060241,2
    C--75829235(+) AACATG/ACACTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1444917231,2
    C--75829258(+) GCCTC-/TTGGTGT 1 -- us2k10--------
    rs1501470831,2
    --75829329(+) CTCAAA/GTCAGG 1 -- us2k10--------
    rs752974621,2
    C,F--75829351(+) ACTTCC/TAGTCC 1 -- us2k12Minor allele frequency- T:0.07NA EA 240
    rs797469221,2
    F--75829420(+) TTCCTG/CGTTTC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs764087131,2
    C--75829540(+) CCAAGG/ATCACA 1 -- us2k14Minor allele frequency- A:0.19CSA WA NA EA 360
    rs1892755481,2
    --75829772(+) AGCCTG/TGGCAA 1 -- us2k10--------
    rs1173900081,2
    C,F--75829891(+) TGAGTC/TCAGGA 1 -- us2k11Minor allele frequency- T:0.13EA 120

    HapMap Linkage Disequilibrium report for SRRM3 (75831216 - 75916605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SRRM3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734684CNV Deletion23290073
    dgv120n16CNV Deletion17901297
    esv2734682CNV Deletion23290073
    esv2422494CNV Duplication17116639
    nsv888387CNV Loss21882294
    nsv888388CNV Loss21882294
    nsv519194CNV Loss19592680
    nsv528969CNV Gain19592680
    essv14753CNV CNV17122850
    dgv2104e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRRM3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SRRM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 222183 HGNC: 26729 AceView: FLJ37078 Ensembl:ENSG00000177679 euGenes: HUgn222183
    ECgene: SRRM3 H-InvDB: SRRM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRRM3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRRM3 gene:
    Search GeneIP for patents involving SRRM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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