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Aliases for SRRM3 Gene

Aliases for SRRM3 Gene

  • Serine/Arginine Repetitive Matrix 3 2 3 5

External Ids for SRRM3 Gene

Previous GeneCards Identifiers for SRRM3 Gene

  • GC07P075752
  • GC07P075831
  • GC07P070917
  • GC07P076201

Summaries for SRRM3 Gene

GeneCards Summary for SRRM3 Gene

SRRM3 (Serine/Arginine Repetitive Matrix 3) is a Protein Coding gene. An important paralog of this gene is SRRM2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM3 Gene

Genomics for SRRM3 Gene

Regulatory Elements for SRRM3 Gene

Enhancers for SRRM3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SRRM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SRRM3 Gene

76,166,675 bp from pter
76,287,292 bp from pter
120,618 bases
Plus strand

Genomic View for SRRM3 Gene

Genes around SRRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM3 Gene

Proteins for SRRM3 Gene

  • Protein details for SRRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/arginine repetitive matrix protein 3
    Protein Accession:
    Secondary Accessions:
    • A6ND75

    Protein attributes for SRRM3 Gene

    597 amino acids
    Molecular mass:
    65249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRRM3 Gene

Post-translational modifications for SRRM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRRM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRM3 Gene

Domains & Families for SRRM3 Gene

Protein Domains for SRRM3 Gene


Suggested Antigen Peptide Sequences for SRRM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CWC21 family.
  • Belongs to the CWC21 family.
genes like me logo Genes that share domains with SRRM3: view

No data available for Gene Families for SRRM3 Gene

Function for SRRM3 Gene

genes like me logo Genes that share phenotypes with SRRM3: view

Animal Model Products

CRISPR Products

miRNA for SRRM3 Gene

miRTarBase miRNAs that target SRRM3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRM3 Gene

Localization for SRRM3 Gene

Subcellular locations from

Jensen Localization Image for SRRM3 Gene COMPARTMENTS Subcellular localization image for SRRM3 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRRM3 Gene

Pathways & Interactions for SRRM3 Gene

SuperPathways for SRRM3 Gene

No Data Available

Interacting Proteins for SRRM3 Gene

Gene Ontology (GO) - Biological Process for SRRM3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SRRM3 Gene

Drugs & Compounds for SRRM3 Gene

No Compound Related Data Available

Transcripts for SRRM3 Gene

Unigene Clusters for SRRM3 Gene

Serine/arginine repetitive matrix 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM3 Gene

No ASD Table

Relevant External Links for SRRM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRRM3 Gene

mRNA expression in normal human tissues for SRRM3 Gene

mRNA differential expression in normal tissues according to GTEx for SRRM3 Gene

This gene is overexpressed in Brain - Cerebellum (x10.7) and Brain - Cerebellar Hemisphere (x10.7).

Protein differential expression in normal tissues from HIPED for SRRM3 Gene

This gene is overexpressed in Liver, secretome (38.5), Adipocyte (12.8), Saliva (10.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SRRM3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SRRM3 Gene:


SOURCE GeneReport for Unigene cluster for SRRM3 Gene:

genes like me logo Genes that share expression patterns with SRRM3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SRRM3 Gene

Orthologs for SRRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRRM3 34
  • 99.39 (n)
  • 98.77 (a)
SRRM3 35
  • 98 (a)
(Bos Taurus)
Mammalia SRRM3 35
  • 65 (a)
(Canis familiaris)
Mammalia SRRM3 35
  • 65 (a)
(Monodelphis domestica)
Mammalia SRRM3 35
  • 53 (a)
(Mus musculus)
Mammalia Srrm3 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SRRM3 35
  • 44 (a)
(Gallus gallus)
Aves SRRM3 35
  • 50 (a)
(Anolis carolinensis)
Reptilia SRRM3 35
  • 50 (a)
(Danio rerio)
Actinopterygii srrm2 35
  • 11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7971 35
  • 6 (a)
(Caenorhabditis elegans)
Secernentea rsr-2 35
  • 21 (a)
Species where no ortholog for SRRM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRM3 Gene

Gene Tree for SRRM3 (if available)
Gene Tree for SRRM3 (if available)

Paralogs for SRRM3 Gene

Paralogs for SRRM3 Gene

(1) SIMAP similar genes for SRRM3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SRRM3: view

Variants for SRRM3 Gene

Sequence variations from dbSNP and Humsavar for SRRM3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2108275 -- 76,274,073(+) CCTTC(A/C)TCCCT intron-variant
rs2158866 -- 76,185,504(+) CATCA(C/T)TGTGT intron-variant
rs2158867 -- 76,185,823(+) TGTGC(A/C)TGGGT intron-variant
rs2158868 -- 76,274,229(+) ATCCC(A/G)TCCTT intron-variant
rs2190425 -- 76,169,850(+) gaatc(A/G)cttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM3 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv3597n106 CNV deletion 24896259
esv2422494 CNV duplication 17116639
esv2734682 CNV deletion 23290073
esv2734684 CNV deletion 23290073
nsv1074520 CNV deletion 25765185
nsv1075974 CNV deletion 25765185
nsv1126797 CNV deletion 24896259
nsv519194 CNV loss 19592680
nsv528969 CNV gain 19592680
nsv955984 CNV deletion 24416366

Variation tolerance for SRRM3 Gene

Gene Damage Index Score: 6.34; 76.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM3 Gene

Disorders for SRRM3 Gene

Relevant External Links for SRRM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SRRM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM3 Gene

Publications for SRRM3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for SRRM3 Gene

Sources for SRRM3 Gene

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