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Aliases for SRRM2 Gene

Aliases for SRRM2 Gene

  • Serine/Arginine Repetitive Matrix 2 2 3 5
  • Serine/Arginine-Rich Splicing Factor-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Tax-Responsive Enhancer Element-Binding Protein 803 3 4
  • Ser/Arg-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • SR-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Splicing Coactivator Subunit SRm300 3 4
  • 300 KDa Nuclear Matrix Antigen 3 4
  • TaxREB803 3 4
  • SRm300 3 4
  • SRL300 3 4
  • Serine/Arginine Repetitive Matrix Protein 2 3
  • Testicular Secretory Protein Li 53 3
  • RNA Binding Protein 3
  • KIAA0324 4
  • HSPC075 3
  • 300-KD 3
  • CWF21 3
  • Cwc21 3

External Ids for SRRM2 Gene

Previous GeneCards Identifiers for SRRM2 Gene

  • GC16P002822
  • GC16P002802
  • GC16P002742
  • GC16P002769
  • GC16P002754
  • GC16P002756
  • GC16P002762

Summaries for SRRM2 Gene

GeneCards Summary for SRRM2 Gene

SRRM2 (Serine/Arginine Repetitive Matrix 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and C2H2 zinc finger domain binding. An important paralog of this gene is SRRM3.

UniProtKB/Swiss-Prot for SRRM2 Gene

  • Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Gene Wiki entry for SRRM2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM2 Gene

Genomics for SRRM2 Gene

Regulatory Elements for SRRM2 Gene

Enhancers for SRRM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002689 1.3 FANTOM5 Ensembl ENCODE 11.5 -60.7 -60666 4.4 DRAP1 SAP130 ARID4B DMAP1 ZIC2 KMT2B ZNF48 ZNF335 POLR2A NR2F6 KCTD5 PRSS27 SRRM2-AS1 SRRM2 PAQR4 KREMEN2 ABCA17P ABCA3 ENSG00000269937 GC16M002686
GH16F002774 1.1 ENCODE 12 +25.0 24952 4.6 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 FOS KLF13 ZNF205 SRRM2 SRRM2-AS1 PRSS27 PAQR4 KREMEN2 SNHG19 ENSG00000260095 PRSS33 PRSS41
GH16F002772 0.8 ENCODE 11.9 +20.8 20843 0.8 CTCF CHD4 RAD21 POLR2A ADNP SMC3 ZNF600 ZNF652 EGR2 ZNF639 SRRM2 PRSS27 SRRM2-AS1 GC16P002845 PIR54527
GH16F003156 1.5 FANTOM5 ENCODE 3.2 +406.5 406465 3.8 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS KLF13 CREBBP THOC6 ZNF213-AS1 CLUAP1 LOC105371055 ZNF263 ZNF597 ZNF205 ENSG00000279473 RNPS1
GH16F002793 1.6 FANTOM5 Ensembl ENCODE 2.6 +42.7 42683 3.6 PKNOX1 GATA2 KLF7 FOS REST SMARCB1 ZNF518A SMARCA4 PBX2 GLIS1 ENSG00000279473 CLUAP1 ZNF213-AS1 RNPS1 ZNF174 MTRNR2L4 ZNF263 MTND1P8 PRSS41 MEFV
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRRM2 on UCSC Golden Path with GeneCards custom track

Promoters for SRRM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001799046 -829 201 HDGF ARNT ZNF740 SIN3A BACH1 ZBTB40 TFDP1 FOXK2 POLR2A MLLT1
ENSR00000502599 971 3001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SRRM2 Gene

Chromosome:
16
Start:
2,752,329 bp from pter
End:
2,772,538 bp from pter
Size:
20,210 bases
Orientation:
Plus strand

Genomic View for SRRM2 Gene

Genes around SRRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM2 Gene

Proteins for SRRM2 Gene

  • Protein details for SRRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ35-SRRM2_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 2
    Protein Accession:
    Q9UQ35
    Secondary Accessions:
    • A6NKB9
    • D3DU97
    • O15038
    • O94803
    • Q6NSL3
    • Q6PIM3
    • Q6PK40
    • Q8IW17
    • Q96GY7
    • Q9P0G1
    • Q9UHA8
    • Q9UQ36
    • Q9UQ37
    • Q9UQ38
    • Q9UQ40

    Protein attributes for SRRM2 Gene

    Size:
    2752 amino acids
    Molecular mass:
    299615 Da
    Quaternary structure:
    • Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex.
    Miscellaneous:
    • Can functionally substitute for CWC12 in yeast.
    SequenceCaution:
    • Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28898.1; Type=Frameshift; Positions=167, 175, 179; Evidence={ECO:0000305}; Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SRRM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRM2 Gene

Post-translational modifications for SRRM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRRM2 Gene

Domains & Families for SRRM2 Gene

Protein Domains for SRRM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ35

UniProtKB/Swiss-Prot:

SRRM2_HUMAN :
  • Belongs to the CWC21 family.
Family:
  • Belongs to the CWC21 family.
genes like me logo Genes that share domains with SRRM2: view

No data available for Gene Families for SRRM2 Gene

Function for SRRM2 Gene

Molecular function for SRRM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Gene Ontology (GO) - Molecular Function for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0047485 protein N-terminus binding IPI 17577209
GO:0070742 C2H2 zinc finger domain binding IDA 17577209
genes like me logo Genes that share ontologies with SRRM2: view
genes like me logo Genes that share phenotypes with SRRM2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRM2 Gene

Localization for SRRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRM2 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRM2 gene
Compartment Confidence
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005681 spliceosomal complex IEA --
GO:0015030 Cajal body IDA 17577209
GO:0016607 nuclear speck IEA,IDA 17577209
genes like me logo Genes that share ontologies with SRRM2: view

Pathways & Interactions for SRRM2 Gene

genes like me logo Genes that share pathways with SRRM2: view

Pathways by source for SRRM2 Gene

Gene Ontology (GO) - Biological Process for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SRRM2: view

No data available for SIGNOR curated interactions for SRRM2 Gene

Transcripts for SRRM2 Gene

Unigene Clusters for SRRM2 Gene

Serine/arginine repetitive matrix 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15:
SP16: -
SP17:
SP18:

ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - -
SP17:
SP18: -

Relevant External Links for SRRM2 Gene

GeneLoc Exon Structure for
SRRM2
ECgene alternative splicing isoforms for
SRRM2

Expression for SRRM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SRRM2 Gene

Protein differential expression in normal tissues from HIPED for SRRM2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRRM2 Gene



Protein tissue co-expression partners for SRRM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRRM2 Gene:

SRRM2

SOURCE GeneReport for Unigene cluster for SRRM2 Gene:

Hs.433343

mRNA Expression by UniProt/SwissProt for SRRM2 Gene:

Q9UQ35-SRRM2_HUMAN
Tissue specificity: Expressed in liver, placenta, and white blood cells.
genes like me logo Genes that share expression patterns with SRRM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SRRM2 Gene

Orthologs for SRRM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM2 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia SRRM2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrm2 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRM2 34 35
  • 79.82 (n)
oppossum
(Monodelphis domestica)
Mammalia SRRM2 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM2 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM2 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10856 34
zebrafish
(Danio rerio)
Actinopterygii srrm2 35
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7971 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsr-2 35
  • 32 (a)
OneToMany
Species where no ortholog for SRRM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRRM2 Gene

ENSEMBL:
Gene Tree for SRRM2 (if available)
TreeFam:
Gene Tree for SRRM2 (if available)

Paralogs for SRRM2 Gene

Paralogs for SRRM2 Gene

genes like me logo Genes that share paralogs with SRRM2: view

Variants for SRRM2 Gene

Sequence variations from dbSNP and Humsavar for SRRM2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1050134 -- 2,770,881(+) TGGGG(G/T)ATTCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1050195 -- 2,771,334(+) TGTTT(C/T)TTAAA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1058855 -- 2,771,762(-) GCCCT(C/G)AGACC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs111312335 -- 2,766,512(+) ATCTC(A/G)ATCTC nc-transcript-variant, reference, missense
rs111325570 -- 2,751,605(+) TCGTA(A/G)TAACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRRM2 Gene

Variant ID Type Subtype PubMed ID
nsv833123 CNV gain+loss 17160897
nsv827522 CNV gain 20364138
nsv471073 CNV loss 18288195
esv2760067 CNV gain+loss 17122850

Variation tolerance for SRRM2 Gene

Residual Variation Intolerance Score: 1.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRM2 Gene

Human Gene Mutation Database (HGMD)
SRRM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM2 Gene

Disorders for SRRM2 Gene

Relevant External Links for SRRM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRM2

No disorders were found for SRRM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM2 Gene

Publications for SRRM2 Gene

  1. The SRm160/300 splicing coactivator subunits. (PMID: 10668804) Blencowe B.J. … Sharp P.A. (RNA 2000) 2 3 4 64
  2. Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. (PMID: 11004489) Sawada Y. … Ohtaki S. (Biochim. Biophys. Acta 2000) 2 3 4 64
  3. A coactivator of pre-mRNA splicing. (PMID: 9531537) Blencowe B.J. … Sharp P.A. (Genes Dev. 1998) 3 4 22 64
  4. SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease. (PMID: 20161708) Shehadeh L.A. … Papapetropoulos S. (PLoS ONE 2010) 3 22 64
  5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 3 4 64

Products for SRRM2 Gene

Sources for SRRM2 Gene

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