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Aliases for SRRM2 Gene

Aliases for SRRM2 Gene

  • Serine/Arginine Repetitive Matrix 2 2 3
  • SRm300 3 4 6
  • Serine/Arginine-Rich Splicing Factor-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Tax-Responsive Enhancer Element-Binding Protein 803 3 4
  • Ser/Arg-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • SR-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Splicing Coactivator Subunit SRm300 3 4
  • 300 KDa Nuclear Matrix Antigen 3 4
  • TaxREB803 3 4
  • KIAA0324 4 6
  • SRL300 3 4
  • Serine/Arginine Repetitive Matrix Protein 2 3
  • RNA Binding Protein 3
  • 300-KD 3
  • CWF21 3
  • Cwc21 3

External Ids for SRRM2 Gene

Summaries for SRRM2 Gene

GeneCards Summary for SRRM2 Gene

SRRM2 (Serine/Arginine Repetitive Matrix 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and C2H2 zinc finger domain binding.

UniProtKB/Swiss-Prot for SRRM2 Gene

  • Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Gene Wiki entry for SRRM2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM2 Gene

Genomics for SRRM2 Gene

Genomic Location for SRRM2 Gene

Start:
2,752,329 bp from pter
End:
2,772,538 bp from pter
Size:
20,210 bases
Orientation:
Plus strand

Genomic View for SRRM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM2 Gene

Proteins for SRRM2 Gene

  • Protein details for SRRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ35-SRRM2_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 2
    Protein Accession:
    Q9UQ35
    Secondary Accessions:
    • A6NKB9
    • D3DU97
    • O15038
    • O94803
    • Q6NSL3
    • Q6PIM3
    • Q6PK40
    • Q8IW17
    • Q96GY7
    • Q9P0G1
    • Q9UHA8
    • Q9UQ36
    • Q9UQ37
    • Q9UQ38
    • Q9UQ40

    Protein attributes for SRRM2 Gene

    Size:
    2752 amino acids
    Molecular mass:
    299615 Da
    Quaternary structure:
    • Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex.
    Miscellaneous:
    • Can functionally substitute for CWC12 in yeast.
    SequenceCaution:
    • Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28898.1; Type=Frameshift; Positions=167, 175, 179; Evidence={ECO:0000305}; Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SRRM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRM2 Gene

Proteomics data for SRRM2 Gene at MOPED

Post-translational modifications for SRRM2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1186

No data available for DME Specific Peptides for SRRM2 Gene

Domains for SRRM2 Gene

Protein Domains for SRRM2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRRM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ35

UniProtKB/Swiss-Prot:

SRRM2_HUMAN
Family:
  • Belongs to the CWC21 family.:
    • Q9UQ35
genes like me logo Genes that share domains with SRRM2: view

No data available for Gene Families for SRRM2 Gene

Function for SRRM2 Gene

Molecular function for SRRM2 Gene

UniProtKB/Swiss-Prot Function: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Gene Ontology (GO) - Molecular Function for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0047485 protein N-terminus binding IPI 17577209
GO:0070742 C2H2 zinc finger domain binding IDA 17577209
genes like me logo Genes that share ontologies with SRRM2: view
genes like me logo Genes that share phenotypes with SRRM2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRRM2 Gene

Localization for SRRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRM2 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRRM2 Gene COMPARTMENTS Subcellular localization image for SRRM2 gene
Compartment Confidence
nucleus 5
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0015030 Cajal body IDA 17577209
GO:0016607 nuclear speck IDA 17577209
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with SRRM2: view

Pathways for SRRM2 Gene

SuperPathways for SRRM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
genes like me logo Genes that share ontologies with SRRM2: view

No data available for Pathways by source for SRRM2 Gene

Transcripts for SRRM2 Gene

Unigene Clusters for SRRM2 Gene

Serine/arginine repetitive matrix 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15:
SP16: -
SP17:
SP18:

ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - -
SP17:
SP18: -

Relevant External Links for SRRM2 Gene

GeneLoc Exon Structure for
SRRM2
ECgene alternative splicing isoforms for
SRRM2

Expression for SRRM2 Gene

mRNA expression in normal human tissues for SRRM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SRRM2 Gene

SOURCE GeneReport for Unigene cluster for SRRM2 Gene Hs.433343

mRNA Expression by UniProt/SwissProt for SRRM2 Gene

Q9UQ35-SRRM2_HUMAN
Tissue specificity: Expressed in liver, placenta, and white blood cells.
genes like me logo Genes that share expressions with SRRM2: view

No data available for mRNA differential expression in normal tissues for SRRM2 Gene

Orthologs for SRRM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM2 35
  • 99.39 (n)
  • 99.49 (a)
SRRM2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRM2 35
  • 79.82 (n)
  • 80.38 (a)
SRRM2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrm2 16
Srrm2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRM2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM2 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10856 35
zebrafish
(Danio rerio)
Actinopterygii srrm2 36
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7971 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsr-2 36
  • 32 (a)
OneToMany
Species with no ortholog for SRRM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRRM2 Gene

ENSEMBL:
Gene Tree for SRRM2 (if available)
TreeFam:
Gene Tree for SRRM2 (if available)

Paralogs for SRRM2 Gene

genes like me logo Genes that share paralogs with SRRM2: view

No data available for Paralogs for SRRM2 Gene

Variants for SRRM2 Gene

Sequence variations from dbSNP and Humsavar for SRRM2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1050134 -- 2,770,881(+) TGGGG(G/T)ATTCC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs2107321 -- 2,757,262(-) AATAT(A/G)CTACA intron-variant
rs2240140 - 2,762,938(-) TTTAG(G/T)TTGGG missense, reference, nc-transcript-variant
rs2240141 -- 2,762,889(-) TTTTG(C/T)TTAGG reference, synonymous-codon, nc-transcript-variant
rs2240142 -- 2,762,646(-) ACTAA(A/G)CTTCT reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM2 Gene

Variant ID Type Subtype PubMed ID
dgv2570n71 CNV Loss 21882294
nsv905152 CNV Loss 21882294
dgv793e1 CNV Complex 17122850
nsv833123 CNV Gain+Loss 17160897
nsv905161 CNV Loss 21882294
nsv905162 CNV Gain 21882294
nsv471073 CNV Loss 18288195
nsv905165 CNV Loss 21882294
nsv827522 CNV Gain 20364138

Relevant External Links for SRRM2 Gene

HapMap Linkage Disequilibrium report
SRRM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM2 Gene

Disorders for SRRM2 Gene

No disorders were found for SRRM2 Gene.

No data available for UniProtKB/Swiss-Prot for SRRM2 Gene

Publications for SRRM2 Gene

  1. A coactivator of pre-mRNA splicing. (PMID: 9531537) Blencowe B.J. … Sharp P.A. (Genes Dev. 1998) 3 4 23
  2. Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. (PMID: 11004489) Sawada Y. … Ohtaki S. (Biochim. Biophys. Acta 2000) 2 3 4
  3. The SRm160/300 splicing coactivator subunits. (PMID: 10668804) Blencowe B.J. … Sharp P.A. (RNA 2000) 2 3 4
  4. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 3 4
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4

Products for SRRM2 Gene

Sources for SRRM2 Gene

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