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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRRM2 Gene

protein-coding   GIFtS: 52
GCID: GC16P002769

Serine/Arginine Repetitive Matrix 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine/Arginine Repetitive Matrix 21 2     SRM3003 5
Ser/Arg-Related Nuclear Matrix Protein Of 300 KDa2 3     300-KD2
Serine/Arginine-Rich Splicing Factor-Related Nuclear Matrix Protein Of 300
KDa2 3
     CWF212
Splicing Coactivator Subunit SRm3002 3     Cwc212
Tax-Responsive Enhancer Element-Binding Protein 8032 3     SRm3002
300 KDa Nuclear Matrix Antigen2 3     RNA Binding Protein2
SRL3002 3     Serine/Arginine Repetitive Matrix Protein 22
SR-Related Nuclear Matrix Protein Of 300 KDa2 3     taxREB8032
KIAA03243 5     TaxREB8033

External Ids:    HGNC: 166391   Entrez Gene: 235242   Ensembl: ENSG000001679787   OMIM: 6060325   UniProtKB: Q9UQ353   

Export aliases for SRRM2 gene to outside databases

Previous GC identifers: GC16P002822 GC16P002802 GC16P002742


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SRRM2 Gene: 
SRRM2 (serine/arginine repetitive matrix 2) is a protein-coding gene. Diseases associated with SRRM2 include colon adenocarcinoma, and acute myeloid leukemia. GO annotations related to this gene include C2H2 zinc finger domain binding and RNA binding. An important paralog of this gene is SRRM3.

UniProtKB/Swiss-Prot: SRRM2_HUMAN, Q9UQ35
Function: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the
catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA
substrate (By similarity). Binds to RNA

Gene Wiki entry for SRRM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRRM2 gene promoter:
         AP-2alpha isoform 3   p53   Brachyury   MyoD   Olf-1   AP-2alpha isoform 2   PPAR-alpha   Pax-4a   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRRM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SRRM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

SRRM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRM2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002769:  view genomic region     (about GC identifiers)

Start:
2,802,330 bp from pter      End:
2,822,539 bp from pter
Size:
20,210 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SRRM2_HUMAN, Q9UQ35 (See protein sequence)
Recommended Name: Serine/arginine repetitive matrix protein 2  
Size: 2752 amino acids; 299615 Da
Subunit: Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70,
SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex
Subcellular location: Nucleus speckle
Miscellaneous: Can functionally substitute for CWC12 in yeast (PubMed:19854871)
Sequence caution: Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Sequence=AAF28898.1; Type=Frameshift;
Positions=167, 175, 179; Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence; Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally
shortened;
Secondary accessions: A6NKB9 D3DU97 O15038 O94803 Q6NSL3 Q6PIM3 Q6PK40 Q8IW17 Q96GY7 Q9P0G1
Q9UHA8 Q9UQ36 Q9UQ37 Q9UQ38 Q9UQ40
Alternative splicing: 3 isoforms:  Q9UQ35-1   Q9UQ35-2   Q9UQ35-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SRRM2: NX_Q9UQ35

Explore proteomics data for SRRM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UQ35

  • SRRM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SRRM2 Protein Expression
    REFSEQ proteins: NP_057417.3  
    ENSEMBL proteins: 
     ENSP00000301740   ENSP00000461181   ENSP00000458870   ENSP00000458718   ENSP00000458647  
     ENSP00000458230   ENSP00000460642   ENSP00000461535   ENSP00000459157  

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    Cloud-Clone Corp. Proteins for SRRM2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0015030Cajal body IDA17577209
    GO:0016607nuclear speck IDA17577209
    GO:0071013catalytic step 2 spliceosome IDA11991638

    SRRM2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR024945 Spt5_C_dom
     IPR013170 mRNA_splic_Cwf21

    Graphical View of Domain Structure for InterPro Entry Q9UQ35

    ProtoNet protein and cluster: Q9UQ35

    UniProtKB/Swiss-Prot: SRRM2_HUMAN, Q9UQ35
    Similarity: Belongs to the CWC21 family


    SRRM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRRM2_HUMAN, Q9UQ35
    Function: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the
    catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA
    substrate (By similarity). Binds to RNA

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0047485protein N-terminus binding IPI17577209
    GO:0070742C2H2 zinc finger domain binding IDA17577209
         
    SRRM2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for SRRM2:
     Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased viability  Increased gamma-H2AX phosphory 
     Increased mitotic index 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SRRM2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SRRM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SRRM2 

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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SRRM2 (see all 17):
    hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-1260b hsa-let-7a-2* hsa-miR-3653 hsa-miR-3658 hsa-let-7g* hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidSRRM2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SRRM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/702 Interacting proteins for SRRM2 (Q9UQ351, 2, 3 ENSP000003017404) via UniProtKB, MINT, STRING, and/or I2D (see all 702)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA1AP081073, ENSP000003648024I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638

    SRRM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRRM2

    Search CenterWatch for drugs/clinical trials and news about SRRM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SRRM2 gene: 
    NM_016333.3  

    Unigene Cluster for SRRM2:

    Serine/arginine repetitive matrix 2
    Hs.433343  [show with all ESTs]
    Unigene Representative Sequence: NM_016333
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000301740(uc002crj.1 uc002crl.1 uc010bsu.1 uc002crk.3)
    ENST00000576924 ENST00000575009 ENST00000575701 ENST00000576894 ENST00000576415
    ENST00000571378 ENST00000574340 ENST00000570971 ENST00000575870 ENST00000573451
    ENST00000571372 ENST00000570655 ENST00000573498 ENST00000572278 ENST00000576076
    ENST00000572952 ENST00000576674

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate SRRM2 (see all 17):
    hsa-miR-1224-3p hsa-miR-513a-5p hsa-miR-1260b hsa-let-7a-2* hsa-miR-3653 hsa-miR-3658 hsa-let-7g* hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidSRRM2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SRRM2 (NM_016333)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRM2

    Additional mRNA sequence: 

    AB002322.3 AB015644.1 AB016087.1 AB016088.1 AB016089.1 AB016090.1 AB016091.1 AB016092.1 
    AF161338.1 AF201422.1 AK025579.1 AK025903.1 BC007752.2 BC009062.1 BC020639.1 BC028054.1 
    BC041155.1 BC046104.1 BC070050.1 BC107087.2 BX537511.1 BX647088.1 X97301.1 

    24/63 DOTS entries (see all 63):

    DT.95351468  DT.91798583  DT.100821089  DT.100821085  DT.450730  DT.91798478  DT.100038480  DT.100038486 
    DT.100821099  DT.120718913  DT.100821082  DT.99943212  DT.97771749  DT.100711397  DT.75147345  DT.120719054 
    DT.100821080  DT.100821098  DT.102839220  DT.120718939  DT.95165046  DT.95165070  DT.100718950  DT.120718933 

    24/452 AceView cDNA sequences (see all 452):

    AB015644 AW001982 BI006638 CA449634 X97301 BE671072 BM852712 AI940189 
    AI940201 AA743746 AU140282 BC041155 T19957 AW939107 AW073890 AB016090 
    AB016087 BU151223 CD627773 CD722216 AW501843 AL041464 CD172410 BM505330 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for SRRM2 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^
    SP1:                                                                    -     -                                                                                 
    SP2:                                                                                                                                                            
    SP3:              -     -                                                                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                -     -                     

    ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                  
    SP2:                    -     -     -     -                           
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for SRRM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRRM2 expression in normal human tissues (normalized intensities)      SRRM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTTAAAG
    SRRM2 Expression
    About this image


    SRRM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   

    See SRRM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRRM2

    SOURCE GeneReport for Unigene cluster: Hs.433343

    UniProtKB/Swiss-Prot: SRRM2_HUMAN, Q9UQ35
    Tissue specificity: Expressed in liver, placenta, and white blood cells

        SABiosciences Custom PCR Arrays for SRRM2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SRRM2
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SRRM2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srrm21 , 5 serine/arginine repetitive matrix 21, 5 83.87(n)1
    87.58(a)1
      17 (12.07 cM)5
    759561  NM_175229.31  NP_780438.21 
     238031875 
    lizard
    (Anolis carolinensis)
    Reptilia SRRM26
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL343287.1(1380876-1400189)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.108562 Transcribed sequence with weak similarity to protein more 72.4(n)    141993450 
    zebrafish
    (Danio rerio)
    Actinopterygii srrm26
    CU672266.16
    (see all 3)
    Uncharacterized protein
    (see all 3)
    18(a)
    18(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    3(32768346-32787254)
    3(1936697-1938732)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16776
    CG79716
    --
    6(a)
    14(a)
    possible ortholog
    possible ortholog
    X(7175122-7299793)
    3L(1654247-1665064)
    worm
    (Caenorhabditis elegans)
    Secernentea C15C6.36
    Protein C15C6.3
    16(a)
    possible ortholog
    I(12207097-12212206)


    ENSEMBL Gene Tree for SRRM2 (if available)
    TreeFam Gene Tree for SRRM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SRRM2 gene
    SRRM32  
    2 SIMAP similar genes for SRRM2 using alignment to 12 protein entries:     SRRM2_HUMAN (see all proteins):
    KIAA0324    SRRM3

    SRRM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/933 SNPs in SRRM2 are shown (see all 933)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836343361,2
    --2804638(+) TGGTAC/TGGAAG 1 -- int10--------
    rs118631301,2
    C,F,H--2804807(+) AGAAAT/GTGATT 1 -- int13Minor allele frequency- G:0.17NA WA 126
    rs1898501931,2
    --2804819(+) TTTGAC/GCCATA 1 -- int10--------
    rs1459460401,2
    --2804850(+) GATTTC/GTGCTT 1 -- int10--------
    rs1385089301,2
    --2804957(+) AGTATA/GTTTTT 1 -- int10--------
    rs1416728111,2
    C--2804977(+) TGTATC/GATGCT 1 -- int10--------
    rs1462057491,2
    C--2805014(+) ATCCTC/TCCCTT 1 -- int10--------
    rs1393817211,2
    --2805055(+) CTCTCC/TGCTTT 1 -- int10--------
    rs1811735991,2
    --2805063(+) TTTACA/GTATTC 1 -- int10--------
    rs1870223611,2
    --2805076(+) TAGGGA/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SRRM2 (2802330 - 2822539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SRRM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv905165CNV Loss21882294
    nsv905152CNV Loss21882294
    nsv471073CNV Loss18288195
    nsv905161CNV Loss21882294
    dgv2570n71CNV Loss21882294
    nsv905162CNV Gain21882294
    nsv827522CNV Gain20364138
    nsv833123CNV Gain+Loss17160897
    dgv793e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606032    OMIM disorders: --

    7 diseases for SRRM2:    About MalaCards
    colon adenocarcinoma    acute myeloid leukemia    parkinson's disease    myeloid leukemia
    leukemia    adenocarcinoma    breast cancer


    SRRM2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for SRRM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRRM2 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with SRRM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SRm160/300 splicing coactivator subunits. (PubMed id 10668804)1, 2, 3 Blencowe B.J.... Sharp P.A. (2000)
    2. Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. (PubMed id 11004489)1, 2, 3 Sawada Y.... Ohtaki S. (2000)
    3. A coactivator of pre-mRNA splicing. (PubMed id 9531537)1, 2, 9 Blencowe B.J.... Sharp P.A. (1998)
    4. Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome. (PubMed id 19854871)1, 2 Grainger R.J....Beggs J.D. (2009)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23524 HGNC: 16639 AceView: SRRM2 Ensembl:ENSG00000167978 euGenes: HUgn23524
    ECgene: SRRM2 H-InvDB: SRRM2

    (According to HUGE)
    About This Section
    HUGE: KIAA0324

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRRM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SRRM2 gene:
    Search GeneIP for patents involving SRRM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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