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Aliases for SRRM2 Gene

Aliases for SRRM2 Gene

  • Serine/Arginine Repetitive Matrix 2 2 3 5
  • Serine/Arginine-Rich Splicing Factor-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Tax-Responsive Enhancer Element-Binding Protein 803 3 4
  • Ser/Arg-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • SR-Related Nuclear Matrix Protein Of 300 KDa 3 4
  • Splicing Coactivator Subunit SRm300 3 4
  • 300 KDa Nuclear Matrix Antigen 3 4
  • TaxREB803 3 4
  • SRm300 3 4
  • SRL300 3 4
  • Serine/Arginine Repetitive Matrix Protein 2 3
  • Testicular Secretory Protein Li 53 3
  • RNA Binding Protein 3
  • KIAA0324 4
  • HSPC075 3
  • 300-KD 3
  • CWF21 3
  • Cwc21 3

External Ids for SRRM2 Gene

Previous GeneCards Identifiers for SRRM2 Gene

  • GC16P002822
  • GC16P002802
  • GC16P002742
  • GC16P002769
  • GC16P002754
  • GC16P002756
  • GC16P002762
  • GC16P002835
  • GC16P002891

Summaries for SRRM2 Gene

GeneCards Summary for SRRM2 Gene

SRRM2 (Serine/Arginine Repetitive Matrix 2) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and C2H2 zinc finger domain binding. An important paralog of this gene is SRRM3.

UniProtKB/Swiss-Prot for SRRM2 Gene

  • Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Gene Wiki entry for SRRM2 Gene

Additional gene information for SRRM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM2 Gene

Genomics for SRRM2 Gene

Regulatory Elements for SRRM2 Gene

Enhancers for SRRM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H002147 2 FANTOM5 Ensembl ENCODE dbSUPER 48 -596.5 -596539 17 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC CRAMP1 ENSG00000260051 ENSG00000261505 TELO2 TBL3 UNKL E4F1 TSC2 SRRM2 ZNF213-AS1
GH16H003148 1.7 Ensembl ENCODE dbSUPER 40.7 +398.9 398857 4 MLX ZFP64 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 CREBBP E4F1 ZNF263 THOC6 ZNF597 ZNF213-AS1 SRRM2 ZNF205 AMDHD2 ENSG00000261938
GH16H003019 1.4 ENCODE dbSUPER 39.8 +270.0 269974 5 MLX DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 ZC3H11A NFYC MEF2D ENSG00000261938 ZNF263 ZNF75A E4F1 TSC2 ERVK13-1 SRRM2 CREBBP ZNF597 SNHG19
GH16H001962 1.4 Ensembl ENCODE 39.4 -788.1 -788108 4 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ENSG00000255513 ENSG00000261505 ENSG00000260051 TELO2 E4F1 UNKL TSC2 SNHG9 CRAMP1 SRRM2
GH16H003004 1.7 FANTOM5 ENCODE dbSUPER 31.2 +255.8 255757 7 HNRNPUL1 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 CREBBP MMP25 ZNF597 LOC107984895 SRRM2 AMDHD2 ZNF263 ZNF598 E4F1 THOC6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRRM2 on UCSC Golden Path with GeneCards custom track

Promoters for SRRM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082539 871 2801 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for SRRM2 Gene

Chromosome:
16
Start:
2,752,329 bp from pter
End:
2,772,538 bp from pter
Size:
20,210 bases
Orientation:
Plus strand

Genomic View for SRRM2 Gene

Genes around SRRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM2 Gene

Proteins for SRRM2 Gene

  • Protein details for SRRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UQ35-SRRM2_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 2
    Protein Accession:
    Q9UQ35
    Secondary Accessions:
    • A6NKB9
    • D3DU97
    • O15038
    • O94803
    • Q6NSL3
    • Q6PIM3
    • Q6PK40
    • Q8IW17
    • Q96GY7
    • Q9P0G1
    • Q9UHA8
    • Q9UQ36
    • Q9UQ37
    • Q9UQ38
    • Q9UQ40

    Protein attributes for SRRM2 Gene

    Size:
    2752 amino acids
    Molecular mass:
    299615 Da
    Quaternary structure:
    • Component of the active spliceosome. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Identified in the spliceosome C complex.
    Miscellaneous:
    • Can functionally substitute for CWC12 in yeast.
    SequenceCaution:
    • Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28898.1; Type=Frameshift; Positions=167, 175, 179; Evidence={ECO:0000305}; Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRRM2 Gene

    Alternative splice isoforms for SRRM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRM2 Gene

Post-translational modifications for SRRM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SRRM2 Gene

Domains & Families for SRRM2 Gene

Gene Families for SRRM2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for SRRM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UQ35

UniProtKB/Swiss-Prot:

SRRM2_HUMAN :
  • Belongs to the CWC21 family.
Family:
  • Belongs to the CWC21 family.
genes like me logo Genes that share domains with SRRM2: view

Function for SRRM2 Gene

Molecular function for SRRM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.

Phenotypes From GWAS Catalog for SRRM2 Gene

Gene Ontology (GO) - Molecular Function for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005515 protein binding IPI 15324660
GO:0047485 protein N-terminus binding IPI 17577209
GO:0070742 C2H2 zinc finger domain binding IDA 17577209
genes like me logo Genes that share ontologies with SRRM2: view
genes like me logo Genes that share phenotypes with SRRM2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRRM2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRM2 Gene

Localization for SRRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRM2 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRM2 gene
Compartment Confidence
nucleus 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0015030 Cajal body IDA 17577209
GO:0016607 nuclear speck IDA,IEA 17577209
genes like me logo Genes that share ontologies with SRRM2: view

Pathways & Interactions for SRRM2 Gene

genes like me logo Genes that share pathways with SRRM2: view

Pathways by source for SRRM2 Gene

Gene Ontology (GO) - Biological Process for SRRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with SRRM2: view

No data available for SIGNOR curated interactions for SRRM2 Gene

Drugs & Compounds for SRRM2 Gene

No Compound Related Data Available

Transcripts for SRRM2 Gene

Unigene Clusters for SRRM2 Gene

Serine/arginine repetitive matrix 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRRM2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15a · 15b · 15c ^
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - - -
SP15:
SP16: -
SP17:
SP18:

ExUns: 16a · 16b · 16c ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2: - - - -
SP3:
SP4:
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - - - - - - - - - -
SP17:
SP18: -

Relevant External Links for SRRM2 Gene

GeneLoc Exon Structure for
SRRM2
ECgene alternative splicing isoforms for
SRRM2

Expression for SRRM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRM2 Gene

Protein differential expression in normal tissues from HIPED for SRRM2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRRM2 Gene



Protein tissue co-expression partners for SRRM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SRRM2 Gene:

SRRM2

SOURCE GeneReport for Unigene cluster for SRRM2 Gene:

Hs.433343

mRNA Expression by UniProt/SwissProt for SRRM2 Gene:

Q9UQ35-SRRM2_HUMAN
Tissue specificity: Expressed in liver, placenta, and white blood cells.

Evidence on tissue expression from TISSUES for SRRM2 Gene

  • Nervous system(5)
  • Blood(4.8)
  • Intestine(4.7)
  • Liver(4.6)
  • Lung(4.6)
  • Muscle(4.6)
  • Eye(4.5)
  • Kidney(3.6)
  • Skin(3)
  • Thyroid gland(2.9)
  • Heart(2.7)
  • Bone marrow(2.4)
  • Spleen(2.4)
  • Stomach(2.4)
  • Lymph node(2.3)
  • Gall bladder(2.2)
  • Adrenal gland(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with SRRM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRM2 Gene

Orthologs for SRRM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM2 34 33
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM2 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srrm2 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRM2 34 33
  • 79.82 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRM2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM2 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM2 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10856 33
zebrafish
(Danio rerio)
Actinopterygii srrm2 34
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7971 34
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsr-2 34
  • 32 (a)
OneToMany
Species where no ortholog for SRRM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRRM2 Gene

ENSEMBL:
Gene Tree for SRRM2 (if available)
TreeFam:
Gene Tree for SRRM2 (if available)

Paralogs for SRRM2 Gene

Paralogs for SRRM2 Gene

genes like me logo Genes that share paralogs with SRRM2: view

Variants for SRRM2 Gene

Sequence variations from dbSNP and Humsavar for SRRM2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000029672 -- 2,753,336(+) CGCAG(C/T)CCCCT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000103778 -- 2,756,369(+) CATGT(-/ACAACGG)GATCG intron-variant, nc-transcript-variant, reference, frameshift-variant
rs1000177608 -- 2,769,008(+) CAGCC(C/T)CACCC nc-transcript-variant, reference, missense
rs1000219278 -- 2,756,221(+) CTTAG(C/T)GTGAA intron-variant
rs1000287967 -- 2,764,782(+) GAAAG(A/T)AGTAG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SRRM2 Gene

Variant ID Type Subtype PubMed ID
esv2760067 CNV gain+loss 17122850
nsv471073 CNV loss 18288195
nsv827522 CNV gain 20364138
nsv833123 CNV gain+loss 17160897

Variation tolerance for SRRM2 Gene

Residual Variation Intolerance Score: 1.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRM2 Gene

Human Gene Mutation Database (HGMD)
SRRM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM2 Gene

Disorders for SRRM2 Gene

Relevant External Links for SRRM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRM2

No disorders were found for SRRM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM2 Gene

Publications for SRRM2 Gene

  1. Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. (PMID: 11004489) Sawada Y … Ohtaki S (Biochimica et biophysica acta 2000) 2 3 4 60
  2. The SRm160/300 splicing coactivator subunits. (PMID: 10668804) Blencowe BJ … Sharp PA (RNA (New York, N.Y.) 2000) 2 3 4 60
  3. A coactivator of pre-mRNA splicing. (PMID: 9531537) Blencowe BJ … Sharp PA (Genes & development 1998) 3 4 22 60
  4. SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease. (PMID: 20161708) Shehadeh LA … Papapetropoulos S (PloS one 2010) 3 22 60
  5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 3 4 60

Products for SRRM2 Gene

Sources for SRRM2 Gene

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