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Aliases for SRRM1 Gene

Aliases for SRRM1 Gene

  • Serine/Arginine Repetitive Matrix 1 2 3
  • Ser/Arg-Related Nuclear Matrix Protein 2 3 4
  • SRM160 3 4 6
  • SR-Related Nuclear Matrix Protein Of 160 KDa 3 4
  • Serine/Arginine Repetitive Matrix Protein 1 3
  • Plenty Of Prolines 101-Like 2
  • 160-KD 3
  • POP101 3

External Ids for SRRM1 Gene

Summaries for SRRM1 Gene

GeneCards Summary for SRRM1 Gene

SRRM1 (Serine/Arginine Repetitive Matrix 1) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for SRRM1 Gene

  • Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.

Gene Wiki entry for SRRM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM1 Gene

Genomics for SRRM1 Gene

Genomic Location for SRRM1 Gene

Start:
24,631,716 bp from pter
End:
24,673,281 bp from pter
Size:
41,566 bases
Orientation:
Plus strand

Genomic View for SRRM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM1 Gene

Regulatory Elements for SRRM1 Gene

Proteins for SRRM1 Gene

  • Protein details for SRRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB3-SRRM1_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 1
    Protein Accession:
    Q8IYB3
    Secondary Accessions:
    • O60585
    • Q5VVN4

    Protein attributes for SRRM1 Gene

    Size:
    904 amino acids
    Molecular mass:
    102335 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, PRPF8, NCBP1, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with BAT1, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compound of RNA export complexes that are released from speckles in a ATP-dependent manner.
    SequenceCaution:
    • Sequence=AAC09321.1; Type=Frameshift; Positions=791; Evidence={ECO:0000305}; Sequence=AAP97290.1; Type=Frameshift; Positions=791; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRRM1 Gene

    Alternative splice isoforms for SRRM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRM1 Gene

Proteomics data for SRRM1 Gene at MOPED

Post-translational modifications for SRRM1 Gene

Other Protein References for SRRM1 Gene

No data available for DME Specific Peptides for SRRM1 Gene

Domains for SRRM1 Gene

Protein Domains for SRRM1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SRRM1_HUMAN
Domain:
  • Contains 1 PWI domain.:
    • Q8IYB3
Family:
  • Belongs to the splicing factor SR family.:
    • Q8IYB3
genes like me logo Genes that share domains with SRRM1: view

No data available for Gene Families for SRRM1 Gene

Function for SRRM1 Gene

Molecular function for SRRM1 Gene

UniProtKB/Swiss-Prot Function: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.

Gene Ontology (GO) - Molecular Function for SRRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with SRRM1: view

miRNA for SRRM1 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SRRM1 Gene

Localization for SRRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRM1 Gene

Nucleus matrix. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRRM1 Gene COMPARTMENTS Subcellular localization image for SRRM1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9531537
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex --
GO:0005829 cytosol TAS --
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with SRRM1: view

Pathways for SRRM1 Gene

genes like me logo Genes that share pathways with SRRM1: view

Gene Ontology (GO) - Biological Process for SRRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 9531537
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing --
genes like me logo Genes that share ontologies with SRRM1: view

Transcripts for SRRM1 Gene

Unigene Clusters for SRRM1 Gene

Serine/arginine repetitive matrix 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:

ExUns: 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SRRM1 Gene

GeneLoc Exon Structure for
SRRM1
ECgene alternative splicing isoforms for
SRRM1

Expression for SRRM1 Gene

mRNA expression in normal human tissues for SRRM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SRRM1 Gene

SOURCE GeneReport for Unigene cluster for SRRM1 Gene Hs.18192

genes like me logo Genes that share expressions with SRRM1: view

Orthologs for SRRM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM1 36
  • 99.85 (n)
  • 100 (a)
SRRM1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRRM1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
-- 37
  • 89 (a)
OneToMany
SRRM1 36
  • 93.44 (n)
  • 98.23 (a)
mouse
(Mus musculus)
Mammalia Srrm1 16
Srrm1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRM1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM1 37
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRRM1 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM1 37
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii srrm1 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta SRm160 37
  • 28 (a)
OneToOne
CG11274 38
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea rsr-1 37
  • 42 (a)
OneToOne
rsr-1 38
  • 43 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6562 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4860 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3168 37
  • 65 (a)
OneToOne
Species with no ortholog for SRRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRM1 Gene

ENSEMBL:
Gene Tree for SRRM1 (if available)
TreeFam:
Gene Tree for SRRM1 (if available)

Paralogs for SRRM1 Gene

Pseudogenes.org Pseudogenes for SRRM1 Gene

genes like me logo Genes that share paralogs with SRRM1: view

No data available for Paralogs for SRRM1 Gene

Variants for SRRM1 Gene

Sequence variations from dbSNP and Humsavar for SRRM1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1045297 -- 24,672,986(+) ttttt(C/T)ttttg utr-variant-3-prime
rs1045334 -- 24,673,170(+) gtttc(A/C)ctgtt utr-variant-3-prime
rs1062916 -- 24,672,962(+) Ggttt(C/T)gtttt utr-variant-3-prime
rs3210750 -- 24,673,194(+) TTTTT(G/T)TGTTT utr-variant-3-prime
rs3795296 -- 24,669,776(-) TAAAA(A/G)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM1 Gene

Variant ID Type Subtype PubMed ID
nsv834458 CNV Loss 17160897
nsv460862 CNV Loss 19166990
esv2745519 CNV Deletion 23290073

Relevant External Links for SRRM1 Gene

HapMap Linkage Disequilibrium report
SRRM1

Disorders for SRRM1 Gene

(1) University of Copenhagen DISEASES for SRRM1 Gene

Relevant External Links for SRRM1

Genetic Association Database (GAD)
SRRM1
genes like me logo Genes that share disorders with SRRM1: view

No data available for UniProtKB/Swiss-Prot for SRRM1 Gene

Publications for SRRM1 Gene

  1. A coactivator of pre-mRNA splicing. (PMID: 9531537) Blencowe B.J. … Sharp P.A. (Genes Dev. 1998) 2 3 4 23
  2. The SRm160/300 splicing coactivator is required for exon-enhancer function. (PMID: 10339552) Eldridge A.G. … Blencowe B.J. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  3. The spatial targeting and nuclear matrix binding domains of SRm160. (PMID: 12624182) Wagner S. … Nickerson J.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  4. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. (PMID: 10908574) McGarvey T. … Blencowe B.J. (J. Cell Biol. 2000) 3 23
  5. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. (PMID: 11991360) Szymczyna B.R. … Arrowsmith C.H. (J. Biomol. NMR 2002) 3 23

Products for SRRM1 Gene

Sources for SRRM1 Gene

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