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SRRM1 Gene

protein-coding   GIFtS: 57
GCID: GC01P024958

Serine/Arginine Repetitive Matrix 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Serine/Arginine Repetitive Matrix 11 2     160-KD2
Ser/Arg-Related Nuclear Matrix Protein1 2 3     POP1012
SRM1602 3 5     Serine/Arginine Repetitive Matrix Protein 12
SR-Related Nuclear Matrix Protein Of 160 KDa2 3     SRm1603
Plenty Of Prolines 101-Like1     

External Ids:    HGNC: 166381   Entrez Gene: 102502   Ensembl: ENSG000001332267   OMIM: 6059755   UniProtKB: Q8IYB33   

Export aliases for SRRM1 gene to outside databases

Previous GC identifers: GC01P024494 GC01P024039 GC01P9A0058 GC01P9A4320 GC01P9A4714 GC01P024714 GC01P024842 GC01P023226


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SRRM1 Gene:
SRRM1 (serine/arginine repetitive matrix 1) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: SRRM1_HUMAN, Q8IYB3
Function: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing
events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging
together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and
SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon
junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and
DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid
substrates

Gene Wiki entry for SRRM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SRRM1 gene promoter:
         NF-1   MEF-2   Pax-2   LUN-1   Pax-2a   MEF-2A   MZF-1   POU2F1   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSRRM1 promoter sequence
   Search Chromatin IP Primers for SRRM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SRRM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.11   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p36

SRRM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRM1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P024958:  view genomic region     (about GC identifiers)

Start:
24,958,207 bp from pter      End:
24,999,772 bp from pter
Size:
41,566 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SRRM1_HUMAN, Q8IYB3 (See protein sequence)
Recommended Name: Serine/arginine repetitive matrix protein 1  
Size: 904 amino acids; 102335 Da
Subunit: Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70,
SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70, SNRPA1, SRRM1
and TRA2B/SFRS10. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, PRPF8, NCBP1, RBM8A,
RNPS1, SRRM1 and ALYREF/THOC4. Interacts with BAT1, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compound
of RNA export complexes that are released from speckles in a ATP-dependent manner
Sequence caution: Sequence=AAC09321.1; Type=Frameshift; Positions=791; Sequence=AAP97290.1; Type=Frameshift;
Positions=791;
1 PDB 3D structure from and Proteopedia for SRRM1:
1MP1 (3D)    
Secondary accessions: O60585 Q5VVN4
Alternative splicing: 2 isoforms:  Q8IYB3-1   Q8IYB3-2   

Explore the universe of human proteins at neXtProt for SRRM1: NX_Q8IYB3

Explore proteomics data for SRRM1 at MOPED

Post-translational modifications: 

  • Citrullinated by PADI4 (By similarity)1
  • Ubiquitination2 at Lys49, Lys54
  • Modification sites at PhosphoSitePlus

  • See SRRM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005830.2  
    ENSEMBL proteins: 
     ENSP00000469151   ENSP00000326261   ENSP00000471819   ENSP00000363510   ENSP00000471084  
     ENSP00000391430   ENSP00000441776  
    Reactome Protein details: Q8IYB3

    SRRM1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SRRM1
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    Novus Biologicals SRRM1 Protein
    Novus Biologicals SRRM1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SRRM1

     
    Search eBioscience for Proteins for SRRM1 

     
    antibodies-online proteins for SRRM1 (2 products) 

     
    antibodies-online peptides for SRRM1

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    antibodies-online antibodies for SRRM1 (19 products) 

    SRRM1 Assay Products:

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    Cloud-Clone Corp. ELISAs for SRRM1
    Cloud-Clone Corp. CLIAs for SRRM1
    Search eBioscience for ELISAs for SRRM1 
    antibodies-online kits for SRRM1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002483 PWI_dom

    Graphical View of Domain Structure for InterPro Entry Q8IYB3

    ProtoNet protein and cluster: Q8IYB3

    UniProtKB/Swiss-Prot: SRRM1_HUMAN, Q8IYB3
    Similarity: Belongs to the splicing factor SR family
    Similarity: Contains 1 PWI domain


    Find genes that share domains with SRRM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SRRM1_HUMAN, Q8IYB3
    Function: Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing
    events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging
    together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and
    SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon
    junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and
    DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid
    substrates

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with SRRM1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SRRM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SRRM1:
    hsa-mir-760 (MIRT036777), hsa-mir-1 (MIRT023485), hsa-mir-324-5p (MIRT043025), hsa-mir-326 (MIRT043660)

    Block miRNA regulation of human, mouse, rat SRRM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SRRM1 (see all 27):
    hsa-miR-4291 hsa-miR-320a hsa-miR-495 hsa-miR-3942-5p hsa-miR-1285 hsa-miR-3138 hsa-miR-944 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidSRRM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SRRM1
    Predesigned siRNA for gene silencing in human, mouse, rat SRRM1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRRM1 (NM_005839)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRM1
    Addgene plasmids for SRRM1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SRRM1_HUMAN, Q8IYB3: Nucleus matrix. Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005681spliceosomal complex ----
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with SRRM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SRRM1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2RNA Polymerase II Transcription Termination
    RNA Polymerase II Transcription Termination0.80
    mRNA 3-end processing0.80
    Cleavage of Growing Transcript in the Termination Region0.80
    3Transport of Mature Transcript to Cytoplasm
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93
    Transport of Mature Transcript to Cytoplasm0.93
    4Formation of RNA Pol II elongation complex
    RNA Polymerase II Transcription0.60
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with SRRM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SRRM1
        mRNA processing

    4 Reactome Pathways for SRRM1
        mRNA Splicing - Major Pathway
    Transport of Mature mRNA derived from an Intron-Containing Transcript
    mRNA 3'-end processing
    Cleavage of Growing Transcript in the Termination Region


    2 Kegg Pathways  (Kegg details for SRRM1):
        RNA transport
    mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SRRM1
    Interactions:

        GeneGlobe Interaction Network for SRRM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SRRM1 (Q8IYB32, 3 ENSP000003262614) via UniProtKB, MINT, STRING, and/or I2D (see all 893)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FUSP356372, 3, ENSP000002541084MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000254108
    BCLAF1Q9NYF82, 3, ENSP000000311354MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000031135
    DDX5P178442, 3, ENSP000002257924MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000225792
    DNAJA1P316892, 3, ENSP000003691274MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000369127
    EEF1A1P681042, 3, ENSP000003300544MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000330054
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000375RNA splicing, via transesterification reactions TAS9531537
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006369termination of RNA polymerase II transcription TAS--
    GO:0006397mRNA processing ----

    Find genes that share ontologies with SRRM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SRRM1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SRRM1 gene: 
    NM_005839.3  

    Unigene Cluster for SRRM1:

    Serine/arginine repetitive matrix 1
    Hs.18192  [show with all ESTs]
    Unigene Representative Sequence: NM_005839
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000471693 ENST00000478890 ENST00000593639 ENST00000323848(uc001bjm.3 uc010oel.2)
    ENST00000466910 ENST00000468822 ENST00000600523 ENST00000462710 ENST00000374389
    ENST00000490543 ENST00000479034(uc010oem.1 uc009vrh.1 uc009vri.1)
    ENST00000596378 ENST00000494934 ENST00000495561 ENST00000485441 ENST00000470243
    ENST00000496882 ENST00000461768
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SRRM1 (see all 27):
    hsa-miR-4291 hsa-miR-320a hsa-miR-495 hsa-miR-3942-5p hsa-miR-1285 hsa-miR-3138 hsa-miR-944 hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidSRRM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SRRM1
    Clone
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    OriGene clones in human, mouse for SRRM1 (see all 8)
    OriGene ORF clones in mouse, rat for SRRM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SRRM1 (NM_005839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SRRM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SRRM1
    Addgene plasmids for SRRM1 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SRRM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SRRM1
      QuantiTect SYBR Green Assays in human, mouse, rat SRRM1
      QuantiFast Probe-based Assays in human, mouse, rat SRRM1

    Additional mRNA sequence: 

    AF048977.1 AK293576.1 AK302498.1 AK307419.1 AK307568.1 BC011019.1 BC017315.2 BC036187.1 
    BC107072.1 

    Selected DOTS entries (see all 27):

    DT.452746  DT.100642918  DT.121446234  DT.97862160  DT.121470206  DT.318378  DT.121446215  DT.121446241 
    DT.318382  DT.121446187  DT.100825661  DT.70100635  DT.70101684  DT.95352276  DT.121317776  DT.100825652 
    DT.100825659  DT.318386  DT.100825653  DT.92027950  DT.121446186  DT.95228282  DT.95352272  DT.121446209 

    Selected AceView cDNA sequences (see all 444):

    AA011252 BQ918762 H29314 AL704047 BQ716385 CF147475 BQ083156 BU902316 
    AA725020 BM828650 AI076125 AW673607 AW502523 BE220976 BU784788 AA909170 
    BM477996 BF915139 NM_005839 BM800450 BU633266 BF983924 AI440205 AW964246 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SRRM1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^
    SP1:              -           -                       -                                                                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                  -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b ^ 19 ^ 20
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SRRM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SRRM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGTTCA
    SRRM1 Expression
    About this image


    SRRM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    SRRM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SRRM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18192
        Custom PCR Arrays for SRRM1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SRRM1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRRM1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Srrm15 serine/arginine repetitive matrix 1   --   4 (67.34 cM) 135320484 
    chicken
    (Gallus gallus)
    Aves SRRM16
    Gallus gallus serine/arginine repetitive matrix 1 ...
    89(a)
    1 ↔ 1
    23(2483363-2500074)
    lizard
    (Anolis carolinensis)
    Reptilia SRRM16
    serine/arginine repetitive matrix 1
    85(a)
    1 ↔ 1
    GL343464.1(142174-162265)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043777.12   -- 75.44(n)    BC043777.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC058068.12   -- 74.26(n)    BC058068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112743   -- 64(a)   69F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea rsr-13   -- 43(a)   I(11186121-11190118)   --
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.65622 Vitis vinifera transcribed sequence with weak similarity more 70.26(n)    CB980988.1 


    ENSEMBL Gene Tree for SRRM1 (if available)
    TreeFam Gene Tree for SRRM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SRRM1 gene

    Find genes that share paralogs with SRRM1           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for SRRM1
    PGOHUM00000240661 PGOHUM00000238089 PGOHUM00000249505 PGOHUM00000241573


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SRRM1 (see all 678)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1496759841,2
    C--24967683(+) GGTGCA/GCACCT 1 -- us2k10--------
    rs1924715251,2
    --24967687(+) CGCACC/TTGTAG 1 -- us2k10--------
    rs120796401,2
    C,F,H--24967910(+) TAACAA/CAAATG 1 -- us2k112Minor allele frequency- C:0.09NS EA NA WA CSA 1213
    rs1825136751,2
    --24967962(+) TTTTCC/TAACAG 1 -- us2k10--------
    rs1862032771,2
    --24968015(+) AGGGTA/GGAAGC 1 -- us2k10--------
    rs1898029781,2
    --24968033(+) CCACTC/TAGGGG 1 -- us2k10--------
    rs1174186031,2
    F--24968060(+) GAAGAG/CACGAT 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1824203181,2
    --24968206(+) AAGACA/CCTGGG 1 -- us2k10--------
    rs1870516131,2
    C--24968220(+) GGCAGG/TTGGTT 1 -- us2k10--------
    rs97252691,2
    C,F,A,H--24968290(+) GGtcaG/Agagag 1 -- us2k1 trp323Minor allele frequency- A:0.41NS EA NA WA CSA 2337

    HapMap Linkage Disequilibrium report for SRRM1 (24958207 - 24999772 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SRRM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745519CNV Deletion23290073
    nsv460862CNV Loss19166990
    nsv834458CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SRRM1
    DNA2.0 Custom Variant and Variant Library Synthesis for SRRM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605975    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SRRM1:
    Bullous pemphigoid

    Find genes that share disorders with SRRM1           About GenesLikeMe

    Genetic Association Database (GAD): SRRM1

    Export disorders for SRRM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SRRM1 gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with SRRM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A coactivator of pre-mRNA splicing. (PubMed id 9531537)1, 2, 3, 9 Blencowe B.J.... Sharp P.A. (Genes Dev. 1998)
    2. The spatial targeting and nuclear matrix binding domains of SRm160. (PubMed id 12624182)1, 2, 9 Wagner S.... Nickerson J.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. The SRm160/300 splicing coactivator is required for exon-enhancer function. (PubMed id 10339552)1, 2, 9 Eldridge A.G.... Blencowe B.J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160. (PubMed id 15024032)1, 2 Wagner S.... Nickerson J.A. (J. Cell Biol. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation. (PubMed id 12944400)1, 2 McCracken S.... Blencowe B.J. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10250 HGNC: 16638 AceView: SRRM1 Ensembl:ENSG00000133226 euGenes: HUgn10250
    ECgene: SRRM1 Kegg: 10250 H-InvDB: SRRM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SRRM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SRRM1 gene:
    Search GeneIP for patents involving SRRM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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