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Aliases for SRRM1 Gene

Aliases for SRRM1 Gene

  • Serine And Arginine Repetitive Matrix 1 2 3
  • Ser/Arg-Related Nuclear Matrix Protein 2 3 4
  • Serine/Arginine Repetitive Matrix 1 2 3 5
  • SR-Related Nuclear Matrix Protein Of 160 KDa 3 4
  • SRM160 3 4
  • Plenty Of Prolines 101-Like 2
  • 160-KD 3
  • POP101 3

External Ids for SRRM1 Gene

Previous GeneCards Identifiers for SRRM1 Gene

  • GC01P024494
  • GC01P024039
  • GC01P9A0058
  • GC01P9A4320
  • GC01P9A4714
  • GC01P024714
  • GC01P024842
  • GC01P024958
  • GC01P023226

Summaries for SRRM1 Gene

GeneCards Summary for SRRM1 Gene

SRRM1 (Serine And Arginine Repetitive Matrix 1) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for SRRM1 Gene

  • Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.

Gene Wiki entry for SRRM1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRM1 Gene

Genomics for SRRM1 Gene

Regulatory Elements for SRRM1 Gene

Genomic Location for SRRM1 Gene

Chromosome:
1
Start:
24,631,716 bp from pter
End:
24,673,281 bp from pter
Size:
41,566 bases
Orientation:
Plus strand

Genomic View for SRRM1 Gene

Genes around SRRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRM1 Gene

Proteins for SRRM1 Gene

  • Protein details for SRRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYB3-SRRM1_HUMAN
    Recommended name:
    Serine/arginine repetitive matrix protein 1
    Protein Accession:
    Q8IYB3
    Secondary Accessions:
    • O60585
    • Q5VVN4

    Protein attributes for SRRM1 Gene

    Size:
    904 amino acids
    Molecular mass:
    102335 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Found in a mRNA splicing-dependent exon junction complex (EJC) with DEK, PRPF8, NCBP1, RBM8A, RNPS1, SRRM1 and ALYREF/THOC4. Interacts with BAT1, CPSF1, RBM8A, RNPS1, and ALYREF/THOC4. Seems to be a compound of RNA export complexes that are released from speckles in a ATP-dependent manner.
    SequenceCaution:
    • Sequence=AAC09321.1; Type=Frameshift; Positions=791; Evidence={ECO:0000305}; Sequence=AAP97290.1; Type=Frameshift; Positions=791; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SRRM1 Gene

    Alternative splice isoforms for SRRM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRRM1 Gene

Proteomics data for SRRM1 Gene at MOPED

Post-translational modifications for SRRM1 Gene

No data available for DME Specific Peptides for SRRM1 Gene

Domains & Families for SRRM1 Gene

Protein Domains for SRRM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SRRM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IYB3

UniProtKB/Swiss-Prot:

SRRM1_HUMAN :
  • Contains 1 PWI domain.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 1 PWI domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with SRRM1: view

No data available for Gene Families for SRRM1 Gene

Function for SRRM1 Gene

Molecular function for SRRM1 Gene

UniProtKB/Swiss-Prot Function:
Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
genes like me logo Genes that share phenotypes with SRRM1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRM1 Gene

Localization for SRRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRRM1 Gene

Nucleus matrix. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRRM1 Gene COMPARTMENTS Subcellular localization image for SRRM1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SRRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA,TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SRRM1: view

Pathways & Interactions for SRRM1 Gene

genes like me logo Genes that share pathways with SRRM1: view

Gene Ontology (GO) - Biological Process for SRRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions TAS 9531537
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006397 mRNA processing IEA --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with SRRM1: view

No data available for SIGNOR curated interactions for SRRM1 Gene

Drugs & Compounds for SRRM1 Gene

No Compound Related Data Available

Transcripts for SRRM1 Gene

Unigene Clusters for SRRM1 Gene

Serine/arginine repetitive matrix 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRRM1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:

ExUns: 18a · 18b ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SRRM1 Gene

GeneLoc Exon Structure for
SRRM1
ECgene alternative splicing isoforms for
SRRM1

Expression for SRRM1 Gene

mRNA expression in normal human tissues for SRRM1 Gene

Protein differential expression in normal tissues from HIPED for SRRM1 Gene

This gene is overexpressed in Lavage (17.4), Serum (10.7), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SRRM1 Gene



SOURCE GeneReport for Unigene cluster for SRRM1 Gene Hs.18192

genes like me logo Genes that share expression patterns with SRRM1: view

Protein tissue co-expression partners for SRRM1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRRM1 Gene

Orthologs for SRRM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SRRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRM1 36
  • 98 (a)
OneToOne
SRRM1 35
  • 99.85 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SRRM1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRRM1 35
  • 93.44 (n)
  • 98.23 (a)
-- 36
  • 97 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srrm1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRRM1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SRRM1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRRM1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRRM1 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii srrm1 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11274 37
  • 64 (a)
SRm160 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rsr-1 37
  • 43 (a)
rsr-1 36
  • 42 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.6562 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4860 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3168 36
  • 65 (a)
OneToOne
Species with no ortholog for SRRM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SRRM1 Gene

ENSEMBL:
Gene Tree for SRRM1 (if available)
TreeFam:
Gene Tree for SRRM1 (if available)

Paralogs for SRRM1 Gene

Pseudogenes.org Pseudogenes for SRRM1 Gene

genes like me logo Genes that share paralogs with SRRM1: view

No data available for Paralogs for SRRM1 Gene

Variants for SRRM1 Gene

Sequence variations from dbSNP and Humsavar for SRRM1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17857102 - 24,650,074(+) GTCTC(A/G)TAGCC nc-transcript-variant, reference, missense
rs1062916 -- 24,672,962(+) Ggttt(C/T)gtttt utr-variant-3-prime
rs3855553 -- 24,672,920(+) AACAA(C/G)TTGAT utr-variant-3-prime
rs3795296 -- 24,669,776(-) TAAAA(A/G)CCTGT intron-variant
rs4617346 -- 24,644,132(+) AAGGT(A/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRM1 Gene

Variant ID Type Subtype PubMed ID
nsv834458 CNV Loss 17160897
nsv460862 CNV Loss 19166990
esv2745519 CNV Deletion 23290073

Variation tolerance for SRRM1 Gene

Residual Variation Intolerance Score: 19.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRM1 Gene

HapMap Linkage Disequilibrium report
SRRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRM1 Gene

Disorders for SRRM1 Gene

Relevant External Links for SRRM1

Genetic Association Database (GAD)
SRRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRM1

No disorders were found for SRRM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRM1 Gene

Publications for SRRM1 Gene

  1. A coactivator of pre-mRNA splicing. (PMID: 9531537) Blencowe B.J. … Sharp P.A. (Genes Dev. 1998) 2 3 4 23 67
  2. The spatial targeting and nuclear matrix binding domains of SRm160. (PMID: 12624182) Wagner S. … Nickerson J.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 23
  3. Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins. (PMID: 12581738) Meissner M. … Barta A. (Exp. Cell Res. 2003) 3 23
  4. 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR. (PMID: 11991360) Szymczyna B.R. … Arrowsmith C.H. (J. Biomol. NMR 2002) 3 23
  5. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. (PMID: 10908574) McGarvey T. … Blencowe B.J. (J. Cell Biol. 2000) 3 23

Products for SRRM1 Gene

Sources for SRRM1 Gene

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