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Aliases for SRRD Gene

Aliases for SRRD Gene

  • SRR1 Domain Containing 2 3
  • Hepatocellular Carcinoma Complicating Hemochromatosis 2 3
  • SRR1 Domain-Containing Protein 3 4
  • SRR1L 3 4
  • HC/HCC 3

External Ids for SRRD Gene

Previous GeneCards Identifiers for SRRD Gene

  • GC22P025209
  • GC22P026879
  • GC22P009827

Summaries for SRRD Gene

GeneCards Summary for SRRD Gene

SRRD (SRR1 Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SRRD Gene

  • May be involved in a circadian clock input pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRD Gene

Genomics for SRRD Gene

Regulatory Elements for SRRD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SRRD Gene

26,483,877 bp from pter
26,494,658 bp from pter
10,782 bases
Plus strand

Genomic View for SRRD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRRD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRD Gene

Proteins for SRRD Gene

  • Protein details for SRRD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SRR1-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6NXP8

    Protein attributes for SRRD Gene

    339 amino acids
    Molecular mass:
    38573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRRD Gene

Proteomics data for SRRD Gene at MOPED

Post-translational modifications for SRRD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRRD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRD Gene

Domains & Families for SRRD Gene

Protein Domains for SRRD Gene


Suggested Antigen Peptide Sequences for SRRD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SRR1 family.
  • Belongs to the SRR1 family.
genes like me logo Genes that share domains with SRRD: view

No data available for Gene Families for SRRD Gene

Function for SRRD Gene

Molecular function for SRRD Gene

UniProtKB/Swiss-Prot Function:
May be involved in a circadian clock input pathway.

Phenotypes for SRRD Gene

GenomeRNAi human phenotypes for SRRD:
genes like me logo Genes that share phenotypes with SRRD: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SRRD TF0716 Srr

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRRD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRD Gene

Localization for SRRD Gene

Subcellular locations from

Jensen Localization Image for SRRD Gene COMPARTMENTS Subcellular localization image for SRRD gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRRD Gene

Pathways & Interactions for SRRD Gene

SuperPathways for SRRD Gene

No Data Available

Interacting Proteins for SRRD Gene

Gene Ontology (GO) - Biological Process for SRRD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with SRRD: view

No data available for Pathways by source and SIGNOR curated interactions for SRRD Gene

Drugs & Compounds for SRRD Gene

No Compound Related Data Available

Transcripts for SRRD Gene

mRNA/cDNA for SRRD Gene

Unigene Clusters for SRRD Gene

SRR1 domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SRRD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRD Gene

No ASD Table

Relevant External Links for SRRD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRRD Gene

mRNA expression in normal human tissues for SRRD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRRD Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SRRD Gene

SOURCE GeneReport for Unigene cluster for SRRD Gene Hs.709914

genes like me logo Genes that share expression patterns with SRRD: view

Protein tissue co-expression partners for SRRD Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRRD Gene

Orthologs for SRRD Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SRRD 35
  • 78.05 (n)
  • 75.26 (a)
  • 72 (a)
(Canis familiaris)
Mammalia SRRD 35
  • 83.46 (n)
  • 78.41 (a)
  • 76 (a)
(Mus musculus)
Mammalia Srrd 35
  • 74.39 (n)
  • 71.36 (a)
Srrd 16
Srrd 36
  • 67 (a)
(Pan troglodytes)
Mammalia SRRD 35
  • 98.9 (n)
  • 99.01 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Srrd 35
  • 72.77 (n)
  • 70.77 (a)
(Monodelphis domestica)
Mammalia SRRD 36
  • 54 (a)
(Gallus gallus)
Aves SRRD 35
  • 62.9 (n)
  • 59.27 (a)
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia srrd 35
  • 55.75 (n)
  • 48.04 (a)
(Danio rerio)
Actinopterygii srrd 35
  • 58.08 (n)
  • 51.55 (a)
srrd 36
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002668 35
  • 47.87 (n)
  • 35.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7988 35
  • 42.48 (n)
  • 29.2 (a)
CG7988 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for SRRD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRRD Gene

Gene Tree for SRRD (if available)
Gene Tree for SRRD (if available)

Paralogs for SRRD Gene

No data available for Paralogs for SRRD Gene

Variants for SRRD Gene

Sequence variations from dbSNP and Humsavar for SRRD Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs12175 -- 26,488,160(+) CTATC(C/T)CAAGA reference, missense
rs3210708 -- 26,490,796(-) ATTTG(A/G)GGTCA intron-variant
rs3210709 -- 26,490,611(-) actcc(A/G)gccgg intron-variant
rs4820682 - 26,488,073(+) TGAAG(A/G)CCCCT missense, reference
rs4820683 -- 26,491,133(+) TATCT(A/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRRD Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855

Variation tolerance for SRRD Gene

Residual Variation Intolerance Score: 60.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRD Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRD Gene

Disorders for SRRD Gene

Relevant External Links for SRRD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SRRD: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRD Gene

Publications for SRRD Gene

  1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  2. Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation. (PMID: 18293417) Sikorska M. … Walker P.R. (J. Neurosci. Res. 2008) 67
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 67
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for SRRD Gene

Sources for SRRD Gene

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