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Aliases for SRRD Gene

Aliases for SRRD Gene

  • SRR1 Domain Containing 2 3 5
  • Hepatocellular Carcinoma Complicating Hemochromatosis 2 3
  • SRR1 Domain-Containing Protein 3 4
  • SRR1L 3 4
  • SRR1-Like Protein 3
  • HC/HCC 3

External Ids for SRRD Gene

Previous GeneCards Identifiers for SRRD Gene

  • GC22P025209
  • GC22P026879
  • GC22P009827

Summaries for SRRD Gene

GeneCards Summary for SRRD Gene

SRRD (SRR1 Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SRRD Gene

  • May be involved in a circadian clock input pathway.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRD Gene

Genomics for SRRD Gene

Regulatory Elements for SRRD Gene

Enhancers for SRRD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G026461 1.3 FANTOM5 ENCODE dbSUPER 23.1 -20.7 -20699 3.7 CTCF MXI1 ESRRA TEAD4 CEBPG ZIC2 RAD21 ZNF316 ZNF143 SMC3 SRRD ASPHD2 HPS4 TPST2
GH22G026640 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +159.5 159528 5.2 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 ZNF766 TPST2 LOC100507599 CRYBB1 CRYBA4 HMGB1P10 MIR548J TFIP11 HPS4 SRRD LINC01422
GH22G026647 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +164.7 164651 2.1 MXI1 SUZ12 MAX SIN3A RBBP5 RAD21 ZNF366 POLR2A SCRT2 SMC3 TPST2 HMGB1P10 SRRD HPS4 MIR548J CRYBB1 CRYBA4 TFIP11 MIAT MIATNB
GH22G026657 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +174.4 174447 2.6 PKNOX1 ATF1 CREB3L1 SIN3A TCF12 GLIS2 ZNF143 KLF7 FOS ZNF263 MIAT CRYBB1 CRYBA4 SRRD HPS4 TFIP11 TPST2 ENSG00000206028 SEZ6L ASPHD2
GH22G026478 1.4 ENCODE dbSUPER 14.3 -1.4 -1394 7.5 HDGF FOXA2 MLX ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 TFIP11 ASPHD2 SRRD HPS4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SRRD on UCSC Golden Path with GeneCards custom track

Genomic Location for SRRD Gene

Chromosome:
22
Start:
26,483,877 bp from pter
End:
26,494,658 bp from pter
Size:
10,782 bases
Orientation:
Plus strand

Genomic View for SRRD Gene

Genes around SRRD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRD Gene

Proteins for SRRD Gene

  • Protein details for SRRD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UH36-SRR1L_HUMAN
    Recommended name:
    SRR1-like protein
    Protein Accession:
    Q9UH36
    Secondary Accessions:
    • Q6NXP8

    Protein attributes for SRRD Gene

    Size:
    339 amino acids
    Molecular mass:
    38573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRRD Gene

Post-translational modifications for SRRD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRRD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRD Gene

Domains & Families for SRRD Gene

Protein Domains for SRRD Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SRRD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UH36

UniProtKB/Swiss-Prot:

SRR1L_HUMAN :
  • Belongs to the SRR1 family.
Family:
  • Belongs to the SRR1 family.
genes like me logo Genes that share domains with SRRD: view

No data available for Gene Families for SRRD Gene

Function for SRRD Gene

Molecular function for SRRD Gene

UniProtKB/Swiss-Prot Function:
May be involved in a circadian clock input pathway.

Phenotypes for SRRD Gene

GenomeRNAi human phenotypes for SRRD:
genes like me logo Genes that share phenotypes with SRRD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRRD

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRD Gene

Localization for SRRD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SRRD gene
Compartment Confidence
mitochondrion 3
cytosol 3
peroxisome 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRRD Gene

Pathways & Interactions for SRRD Gene

No Data Available

Interacting Proteins for SRRD Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000215917%0d%0a9606.ENSP00000215574%0d%0a
Selected Interacting proteins: ENSP00000215917 Q9UH36-SRR1L_HUMAN for SRRD Gene via STRING IID

Gene Ontology (GO) - Biological Process for SRRD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with SRRD: view

No data available for Pathways by source and SIGNOR curated interactions for SRRD Gene

Drugs & Compounds for SRRD Gene

No Compound Related Data Available

Transcripts for SRRD Gene

mRNA/cDNA for SRRD Gene

Unigene Clusters for SRRD Gene

SRR1 domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SRRD

Alternative Splicing Database (ASD) splice patterns (SP) for SRRD Gene

No ASD Table

Relevant External Links for SRRD Gene

GeneLoc Exon Structure for
SRRD
ECgene alternative splicing isoforms for
SRRD

Expression for SRRD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SRRD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRRD Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SRRD Gene



Protein tissue co-expression partners for SRRD Gene

NURSA nuclear receptor signaling pathways regulating expression of SRRD Gene:

SRRD

SOURCE GeneReport for Unigene cluster for SRRD Gene:

Hs.709914

Evidence on tissue expression from TISSUES for SRRD Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SRRD: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SRRD Gene

Orthologs for SRRD Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRRD 34 35
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia SRRD 34 35
  • 83.46 (n)
cow
(Bos Taurus)
Mammalia SRRD 34 35
  • 78.05 (n)
mouse
(Mus musculus)
Mammalia Srrd 34 16 35
  • 74.39 (n)
rat
(Rattus norvegicus)
Mammalia Srrd 34
  • 72.77 (n)
oppossum
(Monodelphis domestica)
Mammalia SRRD 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves SRRD 34 35
  • 62.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia srrd 34
  • 55.75 (n)
zebrafish
(Danio rerio)
Actinopterygii srrd 34 35
  • 58.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002668 34
  • 47.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7988 34 35
  • 42.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for SRRD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRRD Gene

ENSEMBL:
Gene Tree for SRRD (if available)
TreeFam:
Gene Tree for SRRD (if available)

Paralogs for SRRD Gene

No data available for Paralogs for SRRD Gene

Variants for SRRD Gene

Sequence variations from dbSNP and Humsavar for SRRD Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs3747137 Likely benign 26,483,725(+) AGAAA(A/C/T)GTGGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs115916720 Uncertain significance 26,483,749(+) CCTGC(A/G)ACTTC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs147631281 Uncertain significance 26,482,157(+) GAAAT(G/T)TCTAG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs187762406 Uncertain significance 26,483,780(+) GGCAG(A/C/G)GAGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs188205202 Uncertain significance 26,481,947(+) TTCCC(C/T)TCCTT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SRRD Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855

Variation tolerance for SRRD Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SRRD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRD Gene

Disorders for SRRD Gene

Relevant External Links for SRRD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SRRD

No disorders were found for SRRD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRD Gene

Publications for SRRD Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for SRRD Gene

Sources for SRRD Gene

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