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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SRRD Gene

protein-coding   GIFtS: 41
GCID: GC22P026879

SRR1 domain containing
 Explore 3 diseases affiliated with
SRRD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SRRD    

Aliases
for SRRD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SRR1 Domain Containing1 2
SRR1L1 2 3
HC/HCC1 2
SRR1 Domain-Containing Protein2 3
Hepatocellular Carcinoma Complicating Hemochromatosis2
SRR1-Like Protein2

External Ids:    HGNC: 339101   Entrez Gene: 4020552   Ensembl: ENSG000001001047   OMIM: 6022545   UniProtKB: Q9UH363   

Export aliases for SRRD gene to outside databases

Previous GC identifers: GC22P025209 GC22P009827


Summaries
for SRRD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SRR1L_HUMAN, Q9UH36
Function: May be involved in a circadian clock input pathway (By similarity)




Genomic Views
for SRRD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRRD gene promoter:
         AhR   GR   Pax-5   GR-beta   MyoD   Arnt   Pax-3   STAT3   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SRRD promoter sequence
   Search SABiosciences Chromatin IP Primers for SRRD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SRRD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

SRRD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRRD gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P026879:  view genomic region     (about GC identifiers)

Start:
 26,879,843 bp from pter      End:
 26,887,904 bp from pter
Size:
 8,062 bases      Orientation:
 plus strand

Proteins
for SRRD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SRR1L_HUMAN, Q9UH36 (See protein sequence)
Recommended Name: SRR1-like protein  
Size: 339 amino acids; 38573 Da
Secondary accessions: Q6NXP8

Explore the universe of human proteins at neXtProt for SRRD: NX_Q9UH36

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UH36

    • SRRD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001013716.2  
    ENSEMBL proteins: 
     ENSP00000215917  

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    Protein Domains /
    Families
    for SRRD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SRRD for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012942 SRR1-like

    Graphical View of Domain Structure for InterPro Entry Q9UH36

    ProtoNet protein and cluster: Q9UH36

    1 Blocks protein family: IPB012942 SRR1

    UniProtKB/Swiss-Prot: SRR1L_HUMAN, Q9UH36
    Similarity: Belongs to the SRR1 family


    Function
    for SRRD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SRR1L_HUMAN, Q9UH36
    Function: May be involved in a circadian clock input pathway (By similarity)

    miRNA
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    Inhib. RNA
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    Pathways & Interactions
    for SRRD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRRD

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048511rhythmic process IEA--


    SRRD for ontologies           About GeneDecksing



    Drugs & Compounds
    for SRRD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRRD
    Search CenterWatch for drugs/clinical trials and news about SRRD / SRR1L 

    Transcripts
    for SRRD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SRRD gene: 
    NM_001013694.2  

    Unigene Cluster for SRRD:

    SRR1 domain containing
    Hs.709914  [show with all ESTs]
    Unigene Representative Sequence: AK293916
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215917(uc003acp.4 uc010gve.3) ENST00000477945 ENST00000471799


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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK293916.1 BC066962.1 

    8 DOTS entries:

    DT.92440640  DT.95270594  DT.87016562  DT.75107180  DT.92440647  DT.100774480  DT.101970424  DT.92063085 

    24/164 AceView cDNA sequences (see all 164):

    AA676626 BQ187580 BQ184483 BX346501 AW303248 BX363637 CR608203 BF589567 
    AA702583 AI202854 AA454574 CR624414 CR599541 AA831854 AA485750 BM547862 
    BM905655 AA834380 CR616290 CA422182 AW593136 CR616197 AI081958 AI288179 

    GeneLoc Exon Structure


    Expression
    for SRRD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SRRD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTGGCCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SRRD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SRRD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SRRD

    SOURCE GeneReport for Unigene cluster: Hs.709914
        SABiosciences Custom PCR Arrays for SRRD
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SRRD

    Orthologs
    for SRRD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SRRD gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Srrd1 , 5 SRR1 domain containing1, 5 74.68(n)1
    71.31(a)1    		   5 (54.69 cM)5
    701181  NM_027323.21  NP_081599.21 
     1123373925 
    chicken
    (Gallus gallus)    		 Aves SRRD1 SRR1 domain containing 62.09(n)
    58.43(a)    		   416908  NM_001201445.1  NP_001188374.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii srrd1 SRR1 domain containing 54.18(n)
    44.57(a)    		   751717  NM_001045427.1  NP_001038892.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG79881 CG7988 42.33(n)
    29.2(a)    		   42180  NM_142434.3  NP_650691.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SRR16
    		 sensitivity to red light reduced protein
    		 25(a)
    		 1 ↔ 1
    		 5(24000556-24001957)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 sensitivity to red light reduced protein 1, putati...
    sensitivity to red light reduced protein 1, putati...
    (see all 3)    		 6(a)
    5(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 4(29591298-29598464)
    4(29585037-29588628)


    ENSEMBL Gene Tree for SRRD (if available)
    TreeFam Gene Tree for SRRD (if available) 

    Paralogs
    for SRRD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SRRD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/102 NCBI SNPs in SRRD are shown (see all 102)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1891356291,2
    		--26881994(+) GAAGGA/TCCTGT 2 D V mis10--------
    rs2016128361,2
    		--26882017(+) TCTGGA/GGTTCA 2 S G mis10--------
    rs1808711661,2
    		--26882115(+) GAGGGA/GTAACT 1 -- int10--------
    rs57615611,2
    		C,F,A,H,--26882142(+) CGCCCG/ACCCCT 1 -- int124Minor allele frequency- A:0.41NS EA NA WA CSA 2354
    rs1177490531,2
    		--26882177(+) TAATTC/TTGATC 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1179235891,2
    		F,--26882286(+) AATAAA/GTGTTG 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1852248321,2
    		--26882402(+) GGTGGC/TGACAT 1 -- int10--------
    rs1472602851,2
    		--26882446(+) ATCATG/TTTTAT 1 -- int10--------
    rs1881410571,2
    		--26882589(+) CCTCCC/TACCTA 1 -- int10--------
    rs1408285951,2
    		--26882758(+) AAGGCA/GGTGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SRRD (26879843 - 26887904 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SRRD: --

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    Disorders / Diseases
    for SRRD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SRRD for disorders           About GeneDecksing

    OMIM gene information: 602254    OMIM disorders: --

    3 diseases for SRRD:    About MalaCards
    hemochromatosis    hepatocellular carcinoma    carcinoma


    Export disorders for SRRD gene to outside databases

    Publications
    for SRRD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SRRD gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SRRD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    3. Epigenetic modifications of SOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation. (PubMed id 18293417)1 Sikorska M....Walker P.R. (2008)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    8. Molecular cloning of a novel mRNA highly expressed in haemochromatotic human liver and proliferating cells. (PubMed id 8806657)1 Kedar V.... Powell L. (1996)

    External Searches for SRRD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SRRD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 402055 HGNC: 33910 AceView: LOC402055 Ensembl:ENSG00000100104 euGenes: HUgn402055
    ECgene: SRRD H-InvDB: SRRD

    Other Databases showing SRRD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SRRD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SRRD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SRRD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SRRD gene:
    Search GeneIP for patents involving SRRD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SRRD gene

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    About This Section

     
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