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Aliases for SRRD Gene

Aliases for SRRD Gene

  • SRR1 Domain Containing 2 3 5
  • Hepatocellular Carcinoma Complicating Hemochromatosis 2 3
  • SRR1 Domain-Containing Protein 3 4
  • SRR1L 3 4
  • SRR1-Like Protein 3
  • HC/HCC 3

External Ids for SRRD Gene

Previous GeneCards Identifiers for SRRD Gene

  • GC22P025209
  • GC22P026879
  • GC22P009827

Summaries for SRRD Gene

GeneCards Summary for SRRD Gene

SRRD (SRR1 Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SRRD Gene

  • May be involved in a circadian clock input pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRRD Gene

Genomics for SRRD Gene

Regulatory Elements for SRRD Gene

Enhancers for SRRD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F026416 0.6 Ensembl ENCODE 16.2 -66.8 -66829 1.1 JUN CEBPB REST JUND ATF3 STAT3 FOSL2 FOS ZNF600 ZNF24 SRRD ASPHD2 HPS4 LOC100507599 LOC646216 RNA5SP495
GH22F026478 0.4 ENCODE 14.3 -1.4 -1394 7.5 HDGF MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 TFIP11 ASPHD2 SRRD LINC01638 RPL15P22 HPS4
GH22F026492 0.2 ENCODE 14 +9.5 9482 2.4 HDAC1 ATF1 PKNOX1 CREB3L1 INSM2 FEZF1 SCRT2 CREM ZBTB11 TSHZ1 TFIP11 SRRD PIR38333 PIR44880
GH22F026470 1 Ensembl ENCODE 13.9 -12.4 -12443 2.7 TBP ZNF316 JUND JUN FOS MAFK ASPHD2 SRRD HPS4
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SRRD on UCSC Golden Path with GeneCards custom track

Promoters for SRRD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000616198 -77 2001 HDGF MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207

Genomic Location for SRRD Gene

26,483,877 bp from pter
26,494,658 bp from pter
10,782 bases
Plus strand

Genomic View for SRRD Gene

Genes around SRRD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SRRD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SRRD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRRD Gene

Proteins for SRRD Gene

  • Protein details for SRRD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SRR1-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6NXP8

    Protein attributes for SRRD Gene

    339 amino acids
    Molecular mass:
    38573 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SRRD Gene

Post-translational modifications for SRRD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SRRD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRRD Gene

Domains & Families for SRRD Gene

Protein Domains for SRRD Gene


Suggested Antigen Peptide Sequences for SRRD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SRR1 family.
  • Belongs to the SRR1 family.
genes like me logo Genes that share domains with SRRD: view

No data available for Gene Families for SRRD Gene

Function for SRRD Gene

Molecular function for SRRD Gene

UniProtKB/Swiss-Prot Function:
May be involved in a circadian clock input pathway.

Phenotypes for SRRD Gene

GenomeRNAi human phenotypes for SRRD:
genes like me logo Genes that share phenotypes with SRRD: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SRRD Gene

Localization for SRRD Gene

Subcellular locations from

Jensen Localization Image for SRRD Gene COMPARTMENTS Subcellular localization image for SRRD gene
Compartment Confidence
cytosol 3
mitochondrion 3
peroxisome 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SRRD Gene

Pathways & Interactions for SRRD Gene

SuperPathways for SRRD Gene

No Data Available

Interacting Proteins for SRRD Gene

Selected Interacting proteins: Q9UH36-SRR1L_HUMAN for SRRD Gene via IID

Gene Ontology (GO) - Biological Process for SRRD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with SRRD: view

No data available for Pathways by source and SIGNOR curated interactions for SRRD Gene

Transcripts for SRRD Gene

mRNA/cDNA for SRRD Gene

Unigene Clusters for SRRD Gene

SRR1 domain containing:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SRRD Gene

No ASD Table

Relevant External Links for SRRD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SRRD Gene

mRNA expression in normal human tissues for SRRD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SRRD Gene

This gene is overexpressed in Prostate (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SRRD Gene

Protein tissue co-expression partners for SRRD Gene

NURSA nuclear receptor signaling pathways regulating expression of SRRD Gene:


SOURCE GeneReport for Unigene cluster for SRRD Gene:

genes like me logo Genes that share expression patterns with SRRD: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SRRD Gene

Orthologs for SRRD Gene

This gene was present in the common ancestor of animals.

Orthologs for SRRD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SRRD 34 35
  • 98.9 (n)
(Canis familiaris)
Mammalia SRRD 34 35
  • 83.46 (n)
(Bos Taurus)
Mammalia SRRD 34 35
  • 78.05 (n)
(Mus musculus)
Mammalia Srrd 34 16 35
  • 74.39 (n)
(Rattus norvegicus)
Mammalia Srrd 34
  • 72.77 (n)
(Monodelphis domestica)
Mammalia SRRD 35
  • 54 (a)
(Gallus gallus)
Aves SRRD 34 35
  • 62.9 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia srrd 34
  • 55.75 (n)
(Danio rerio)
Actinopterygii srrd 34 35
  • 58.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002668 34
  • 47.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7988 34 35
  • 42.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
Species where no ortholog for SRRD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SRRD Gene

Gene Tree for SRRD (if available)
Gene Tree for SRRD (if available)

Paralogs for SRRD Gene

No data available for Paralogs for SRRD Gene

Variants for SRRD Gene

Sequence variations from dbSNP and Humsavar for SRRD Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1045523 -- 26,491,863(-) TAAAA(C/T)GGGAC downstream-variant-500B, utr-variant-3-prime
rs111309451 -- 26,489,426(+) CAGGA(G/T)TTTGC intron-variant
rs111524847 -- 26,485,650(+) TTGGG(A/G)ATGAT intron-variant, upstream-variant-2KB
rs112158657 -- 26,491,956(+) GTTTA(C/T)TTACA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs112398005 -- 26,485,503(+) TAAAG(A/C)AAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SRRD Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855

Variation tolerance for SRRD Gene

Residual Variation Intolerance Score: 60.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SRRD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SRRD Gene

Disorders for SRRD Gene

Relevant External Links for SRRD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SRRD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SRRD Gene

Publications for SRRD Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for SRRD Gene

Sources for SRRD Gene

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